Our medical pioneers and compassionate caregivers have transformed cancer treatment and saved countless lives worldwide, but millions still die from cancer each year. The Dana-Farber Campaign aims to Defy Cancer by dramatically accelerating our success in: Revolutionary Science Extraordinary Care Exceptional Expertise Help us reach our 2 billion dollar goal! ANNOUNCING

SUMMER 2021 Volume 24 | Issue 3

Dana-Farber.org and JimmyFund.org THANKING THOSE WHO MAKE A DIFFERENCE ImpactDefyCancer.org

Hale Family gift to The Dana-Farber Campaign 2 is the largest ever to pancreatic cancer research The Dana-Farber at the Institute Campaign 4 New funds for new ideas 7 Fueling the next generation 8 Hope for childhood cancers 10 Advancing early Institute Trustee Judith B. Hale (right), her son Robert T. Hale Jr., and his wife, Karen Hale, have made a visionary gift of $50 million to detection The Dana-Farber Campaign to transform treatment and advance early detection and prevention for pancreatic cancer, the largest to this disease area in Dana-Farber history.

ontinuing their family’s deep commitment to conquering 12 C pancreatic cancer, Judith B. “We are investing in the exceptional talent at Changing the Hale, her son, Robert T. Hale Jr., and Dana-Farber because we are committed to ovarian paradigm his wife, Karen Hale, have pledged an finding a cure. That would be a wonderful honor additional $50 million to Dana-Farber Cancer Institute. This gift, one of the for my husband and legacy for our family.” largest single gifts in the Institute’s — JUDITH B. HALE, Institute Trustee history, will support the Hale Family Center for Pancreatic Cancer Research, founded in 2016 with $15 million from Judith, Robert, and Karen. clinical trials to test new therapies based and around the world. With this This new gift, the largest-ever gift upon discoveries from these initiatives. incredibly generous, transformational to pancreatic cancer research at Dana- “Our intention is to substantially gift, the Hale Family is providing us Farber, will enable a wide range of speed the pace of research and new with an unprecedented opportunity, Dana-Farber Cancer Institute has been the top ambitious work in two main areas: treatments for this terrible disease,” and responsibility, to do just that.” ranked cancer hospital in New England by U.S. News early detection and prevention, and said Judith Hale, a member of the “More than 60,000 people will be and World Report for 20 consecutive years, and is precision medicine and biology. Dana-Farber Board of Trustees. “We diagnosed with pancreatic cancer this the only cancer center in the country ranked in the Currently a national leader in the field, are investing in the exceptional talent at year, far too often at a late stage,” said top 6 for both adult and pediatric cancer programs. the Hale Family Center for Pancreatic Dana-Farber because we are committed Karen Hale. “It is critical to detect it Cancer Research will launch teams to finding a cure. That would be a early when it is most vulnerable, and to Dana-Farber Cancer of scientists to leverage health system wonderful honor for my husband and have newer, more advanced treatments Institute was named the data to identify those at highest risk legacy for our family.” available when we do. Dana-Farber has #3 cancer center in the for pancreatic cancer, detect it earlier “Working in partnership with the the best team of scientists and clinicians world by Newsweek in its through new imaging approaches and Hale Family, we have already made to do this urgent work.” World’s Best Specialized Hospitals ranking. blood tests, and develop new treatments significant progress against pancreatic for pre-invasive and early invasive cancer,” said Dana-Farber President A Generational Legacy pancreatic cancers. and CEO Laurie H. Glimcher, MD. This gift is in honor of Robert The center will also investigate the “Yet far too many families are still T. “Bob” Hale Sr., a patient of the biology and interplay of pancreatic devastated by this disease. We share the Institute, who died in 2008, and cancer cells, the immune system, and Hale Family’s bold vision to eradicate stromal cells, and develop a series of pancreatic cancer and save lives, here continued on page 14 ANNOUNCING

Dear Friends, Announcing

I am thrilled to welcome you to this special edition The Dana-Farber Campaign of our Impact newsletter, which celebrates the announcement of The Dana-Farber Campaign. This hile cancer discoveries and these numbers, we need to discover historic $2 billion campaign is one of the largest ever treatments are advancing new ways to treat every patient with in the U.S. to be focused solely on cancer. We are bold, W at an extraordinary pace, effective precision therapies, advance ambitious, and, with your help, ready to Defy Cancer. there is a critical need to accelerate research to better understand and avoid Throughout this issue, you’ll read about the progress. Many cancers remain disease recurrence, and uncover better strategic initiatives that will be advanced by the campaign and the generous difficult to diagnose early and hard ways to prevent cancer from starting donors whose partnership is making these advances possible. On page 1, we to treat. Certain cancers are striking or advancing. These efforts are only are honored to share the news of an extraordinary new gift of $50 million from younger people more frequently and possible with philanthropic support. Institute Trustee Judy Hale and her son and daughter-in-law. This incredible eluding detection. Cancer disparities “With the help of generous donors, gift supports key priorities of The Dana-Farber Campaign, accelerating efforts and barriers to equitable care persist. we have made great discoveries in to develop new treatments for patients, detect cancer early when it is more Dana-Farber Cancer Institute is cancer and today we know more about easily treated, and even prevent it before it begins. committed to overcoming these this terrible disease than ever before,” The deep dedication and generosity of all our Trustees laid the foundation challenges. We know that together said Laurie H. Glimcher, MD, Dana- for The Dana-Farber Campaign, and they continue to lead the way. We are with our community of support, we Farber president and CEO and the so grateful for the commitment of Trustees Michael Eisenson and Monica can prevent, treat, and Defy Cancer Richard and Susan Smith Professor Chandra, Chair and Vice Chair of The Dana-Farber Campaign, of their at every turn—resulting in more of Medicine. “We are relentlessly Campaign Cabinet, and of our entire Board—including Larry Lucchino, lives saved and accelerating efforts to determined to take what we are who continues his leadership of the Jimmy Fund as the Chairman. I’m deeply ultimately defeat cancer. learning, build on it, and defeat this thankful for his continued support of the campaign and of Dana-Farber. That is why the Institute is proud disease, because patients everywhere We are also celebrating important partners like Make-A-Wish Foundation to announce The Dana-Farber are depending on us. There is no time of Massachusetts & Rhode Island, which recently recognized Dana-Farber Campaign. With a goal of $2 billion, to waste. The Dana-Farber Campaign with its Community Hero Award in honor of our 33-year partnership, and the this is the most ambitious fundraising helps us marshal the resources to Helen Gurley Brown Foundation, which welcomed the newest cohort of Helen campaign in the Institute’s history prevent, treat, and Defy Cancer.” Mentors and Fellows and launched a new Trailblazers initiative to advance and one of the largest ever in the U.S. The Dana-Farber Campaign will women in science. focused solely on cancer. accelerate our success against cancer by The story of Dana-Farber and the Jimmy Fund is one of passionate Announced to the Dana-Farber supporting three strategic priorities: commitment and deep community partnerships such as these. I have every Board of Trustees at their May 10 confidence that we will achieve our ambitious campaign goals, because I have meeting and to the public during Revolutionary Science witnessed firsthand the unwavering and fierce commitment of all of you. a virtual event on May 17, the Science at Dana-Farber is rapidly So I invite you to move forward with us as we continue to break new announcement of the campaign comes transforming our understanding about ground, and sincerely hope this special edition of our newsletter will inspire at a crucial time. Scientific progress how cancer develops and how to and inform you about The Dana-Farber Campaign. Together we will all make and key discoveries are making treat it. While Institute findings have an impact on the future of cancer research and care! new avenues in cancer medicine led to new therapies and protocols possible, yet the need for innovation saving lives around the world, our Sincerely, across cancer research and patient work is not done until we have care is critical. Eight million people effective options for every patient. worldwide still die from cancer each Gifts to The Dana-Farber Campaign year. One in two men and one in will support crucial research areas Melany N. Duval three women will be diagnosed with including precision prevention and Senior Vice President and Chief Philanthropy Officer cancer in their lifetimes. To change early detection; data science, including

Meet the Chair and Vice Chair of The Dana-Farber Campaign

ichael Eisenson is Founding Partner and was taking place at Dana-Farber, and Managing Director of Charlesbank Capital meet many wonderful doctors. Partners and has served on Dana-Farber’s M What excites you about Board of Trustees since 1991. Monica Chandra is The Dana-Farber Campaign? Managing Partner at 3EDGE Asset Management and has been a member of the Board since 2015. We sat Michael: The Dana-Farber Campaign down with Michael and Monica to learn about their is a really bold effort to attract personal connections to Dana-Farber and what excites resources to the challenge of learning them about The Dana-Farber Campaign. how to diagnose and treat the broadest possible range of cancers, many of How did you first come to be involved which remain highly resistant to with Dana-Farber? treatment or evade early diagnosis. Institute Trustees Monica Chandra and Michael Eisenson are Vice Chair Michael: About 30 years ago, I was approached by Monica: My mother-in-law lost her and Chair, respectively, of The Dana-Farber Campaign. Dr. David Livingston and Dr. Baruj Benacerraf— battle with cancer a few years ago. who was President of the Institute at that time—to Watching that journey was painful Why did you choose to take on a leadership help them attract commercial support for early stage but, in some ways, very inspiring. role in this campaign? research. That project led to a funding partnership I have witnessed firsthand the amazing care, the between Dana-Farber and what is now Novartis that groundbreaking research, and the dedication of the Michael: One of the keys to success for great continues to this day. Dana-Farber team. The Dana-Farber Campaign hospitals and research institutions in the U.S. is the partnership between talented faculty and staff and the Monica: About 15 years ago, I joined a committee will help fund the best minds to conquer this awful volunteers and philanthropists who support them. supporting the Susan F. Smith Center for Women’s disease that can strike any of our loved ones. I know Serving as Chair of The Dana-Farber Campaign is an Cancers. It was a great way to learn about the there’s no better cause to give your time and your important way that I, as a non-medical person, can Institute, stay engaged with the exciting research that resources. contribute to that partnership.

2 Impact | SUMMER 2021 artificial intelligence and machine The Dana-Farber Campaign began learning; precision immunotherapy; its “quiet” phase in October 2017 and drug development; and more. 60 percent of the goal has been raised. The Institute anticipates the campaign Extraordinary Care will last seven years and close at the end Total Patient Care started here. of September 2024. While Dr. Sidney Farber revolutionized “Achieving the ambitious goals cancer care globally with chemotherapy, of The Dana-Farber Campaign will his core philosophy of "Total Patient take the deep engagement of our Care" was equally groundbreaking, full community of supporters,” said and has since been adopted around the Michael Eisenson, chair of The Dana- world. Most Dana-Farber clinicians Farber Campaign and Institute Trustee. also conduct research, providing “With that support, Dana-Farber patients with ready access to more will lead the work to Defy Cancer than 1,100 clinical trials and speeding and achieve what was once thought the pathway “from bench to bedside” impossible.” ■ and back again. Campaign funds will support new clinical trials of promising therapeutics, spark innovations in The Dana-Farber Campaign research-based care, expand access to Cabinet Dana-Farber’s high-quality care in Chair underserved populations, help address Michael Eisenson cancer disparities, and more. Vice Chair Monica Chandra Exceptional Expertise Dana-Farber is committed to Members Josh Bekenstein providing its expert scientists and Jane Brock-Wilson clinicians with the resources they David Dechman need to provide world-class care and Laurie H. Glimcher, MD pursue innovative research. Gifts to the Phill Gross campaign will enable Dana-Farber to Michele Kessler continue attracting and retaining the Jeannie Lavine best talent, allow scientists to explore Jonathan Lavine Richard Lubin new ideas that could lead to the next Larry Lucchino cure, and provide clinicians more time James McCann with their patients. Karen Linde Packman Barrett J. Rollins, MD, PhD At a virtual event announcing The Dana-Farber Campaign to the public on Support for the campaign may be in Barbara Sadowsky May 17, notable friends shared their hope for a cancer-free future, including Jim Sadowsky (from top, left to right): Massachusetts Governor Charlie Baker, journalist the form of gifts to specific initiatives and author Tom Brokaw, actor Pierce Brosnan, singer/songwriter Andy Eric Schlager or to Essential Opportunities that Grammer, Boston Mayor Kim Janey, 2014 Boston Marathon Champion Meb Billy Starr provide flexible funding across the Keflezighi,TODAY Co-Anchor and TODAY with Hoda & Jenna Co-Host Beth Terrana Institute, including the Jimmy Fund, Hoda Kotb, comedian and author Amy Poehler, Pan-Mass Challenge The Defy Cancer Fund, and the As of May 17, 2021 Founder and Executive Director Billy Starr, and comedian George Wallace. Presidential Initiatives Fund.

Monica: I strongly believe that leadership can make of cancer significantly reduced, especially on the lives Monica: The very real hope that someday we will a transformational difference in institutions. Dr. of younger and otherwise healthy people. Investing in conquer this awful disease. Glimcher has a bold vision and doing anything we cancer research and development is a rational part of What makes Dana-Farber a special place? can to support that vision is a great way to give back anyone’s philanthropic program. I would encourage to an institution I love so much. people to learn about Dana-Farber, where they’ll find Both: The people. the deepest research and development expertise doing Michael: Their talent, their compassion, and the What impact can the donor community this work anywhere in the world. astonishing depth of the bench. I’ve been close to have as partners in this campaign? Monica: Sadly, cancer impacts everybody, so Dana-Farber for 30 years and I’m still struck by this Michael: Donors have always been an essential part of supporting this cause helps everyone. There are many every time I meet a new person on the team and every the story of Dana-Farber—from the earliest days when renowned hospitals, but what excites me the most time I see a person step into the role of someone the Jimmy Fund and the Dana Foundation supported about Dana-Farber is our singular focus. Eradicating thought to be irreplaceable. This combination of the work led by Dr. Sidney Farber, and continuing this disease is our sole mission. Sometimes we think skill and character just seems to be wonderfully self- today, when philanthropy supports a substantial part about Dana-Farber as a local institution, but the reinforcing and regenerating and I think it’s at the of the research activity at the Institute every year. reach of Dana-Farber is global. What we do, what our heart of what makes Dana-Farber so unique. Monica: One of my favorite places at Dana-Farber researchers do, what our doctors do, benefits patients Monica: Dr. Glimcher has laid out a bold vision is the Zebrafish Display. Reading each message on everywhere. for us, for this campaign, and for what she wants the display is a poignant and powerful reminder of the Institute to accomplish. We are fortunate to What motivates your own philanthropic many different interests that draw donors to this have the most dedicated doctors, nurses, and staff support of Dana-Farber? amazing institution. My hope is that, as part of this along with a Board that cares deeply. I think the campaign, we will provide opportunities for donors Michael: My commitment to invest both time and people at all levels at this Institute truly make this to discover for themselves the many ways they can financial resources started with a personal story. an extraordinary place. ■ serve this mission. My mother was one of the finest people I have ever known, and my family lost her to cancer when she What would you say to someone unfamiliar was only 45. After I began my career and my own Learn more about with Dana-Farber to motivate them to family, I determined that I needed to do what I could The Dana-Farber Campaign at invest in our work? to help avoid this kind of tragic loss for other families. Michael: Everyone’s life has been affected by cancer That led me to Dana-Farber. defycancer.org and we all have a keen interest in seeing the impact

10% of all designated gifts supports our Faculty Research Fund to advance Dana-Farber’s research mission SUMMER 2021 | Impact 3 ANNOUNCING

Lucchino leads the way again with a generous gift to The Dana-Farber Campaign

ancer touches everyone, so all Larry Lucchino has repeatedly risen in the Institute’s future through new funding, and the campaign allows have a stake in defying it at every to the occasion for Dana-Farber and planned giving. us to pursue solutions to the problem C turn. Dana-Farber is leading the its patients in an array of leadership Now, as The Dana-Farber Campaign of cancer in new, better, and different way in this global effort thanks to the roles. As president and CEO of the continues to gain momentum, ways.” Lucchino said. “I am proud of help of a committed community of Boston Red Sox from 2002 to 2015, Lucchino is once again helping to lead what Dana-Farber does in and beyond supporters and dedicated champions he deepened the Jimmy Fund’s the charge through his generous gift our community, and I am honored to like Boston legend, Larry Lucchino. partnership with the team by helping and his service as a member of the support it any way I can.” ■ Recently, Lucchino made a gift to establish such beloved annual Campaign Cabinet. of $500,000 to The Dana-Farber traditions as the WEEI/NESN Jimmy A longtime Dana- Campaign, to support capital projects Fund Radio-Telethon and trips to Farber patient and strategic initiatives through Spring Training for Jimmy Fund who first came to the Presidential Initiatives Fund. Clinic patients and caregivers. In 2016, the Institute for His philanthropy underscores the Lucchino signed on as Chairman of treatment while still campaign’s cornerstone priorities of the Jimmy Fund, serving as the lead living in Washington, supporting revolutionary science, ambassador and public spokesperson to D.C., Lucchino has extraordinary care, and exceptional increase grassroots support for Dana- personal knowledge expertise to create better outcomes Farber’s mission. of and gratitude for for patients everywhere. An Institute Trustee since 2003, the Institute’s impact Lucchino’s generosity was recognized Lucchino has been deeply involved in in New England, by naming The Imagine Display, a Dana-Farber’s fundraising efforts on across the country, whimsical representation of Dana- many fronts. He served as co-chair and throughout Farber’s signature “bench to bedside” of the Institute’s ambitious Mission the world. And he research model through the eyes of Possible campaign from 2004 to 2011 believes that the our youngest patients. Opening in and chair of the Trustee Philanthropy campaign, along November 2021, The Imagine Display, Committee from 2014 to 2020. He with all who support made possible by the Lucchino Family, and wife Stacey walk in the Boston it, empowers Dana- offers an array of unique naming Marathon® Jimmy Fund Walk, Stacey Farber to make opportunities for all donors that rides in the Pan-Mass Challenge, and an even greater will further generate critical funding both are members of the Dana-Farber difference. “New Larry Lucchino, Institute Trustee and Chairman of the Jimmy Fund, made a generous gift to The Dana-Farber for cancer research and care at the Society, a special family of forward- ideas can only be Campaign. Institute. thinking supporters who have invested generated through

Farber Family legacy lives Nate Eovaldi named 2021 on through generous giving Jimmy Fund Captain hen it comes to cancer years to focus on phase 2 and phase research, Dana-Farber 3 trials, leaving a gap in funding for W Cancer Institute’s founder, early phase trials, which are essential in Sidney Farber, MD, is not the only studying interactions between therapies family member to make an impact. His and tumor cells. nephew James Farber serves as trustee of “This gift will greatly help Dana- the Anne and Jason Farber Foundation, Farber to leverage its unique drug which has made major contributions development expertise, tools, and to brain cancer research at Dana- clinical trial infrastructure to develop Farber over more than 30 years. The innovative treatments,” says Patrick foundation was established by Sidney’s Wen, MD, the center’s director. ■ brother Jason and his wife, Anne—James’ parents. When James lost his mother to brain cancer in 1982, supporting this research became an even more special way to celebrate the family legacy and improve the lives of brain cancer patients. Boston Red Sox pitcher Nate Eovaldi has been named this year’s Jimmy Fund Captain, to help support and promote the mission of Dana-Farber and The foundation’s latest gift the Jimmy Fund. Every year, a Red Sox player takes on this role to serve was designated specifically as an ambassador to the Jimmy Fund community, attending fundraising for early phase clinical events, visiting patients, and building support for cancer care and research research in the Center for at Dana-Farber. Many of these activities will take place virtually this year Neuro-Oncology at Dana- to mitigate potential spread of the virus and keep everyone safe. “Since Farber, which offers state- joining the Red Sox in 2018, I have met so many incredible Dana-Farber of-the-art treatment for patients and their families at the WEEI/NESN Jimmy Fund Radio-Telethon,” patients with brain tumors, says Eovaldi. “I’m honored and excited to become more involved. I have spinal cord tumors, and long admired the work of the previous Jimmy Fund Captains and look neurologic complications from forward to playing a larger role in the special relationship between the cancer. National funding The Anne and Jason Farber Foundation has Red Sox, Dana-Farber, and the Jimmy Fund.” ■ funded brain cancer research at Dana-Farber since opportunities in brain cancer 1990. research have shifted in recent

4 Impact | SUMMER 2021 Salice Foundation gift broadens patient navigation program

esidents of many Boston and rectal cancer and about communities face significant 40% more likely to die from it R barriers to accessing affordable and than most other racial or ethnic quality health care. With a $1 million groups. Hispanic individuals gift from the Salice Family Foundation, diagnosed with liver cancer are Dana-Farber is reimagining its patient twice as likely to die as a result navigation program to build an Institute- of the disease than non-Hispanic wide program that ensures support across whites. all disease areas for patients with sub- “As a clinician, I have optimal access to health care services. witnessed firsthand the The gift, which is intended to inspire challenges that patients of other donors, advances a key strategic low socioeconomic status and priority of the Institute’s comprehensive patients of color face, whether fundraising campaign by equalizing it is language, transportation, or care and ensuring that everyone who is education about their treatment diagnosed with cancer can access Dana- options,” said Lathan. “Recent Farber’s cutting-edge treatments and Christopher Lathan, MD, MS, MPH, and Magnolia Contreras, MSW, MBA, are leading the events have catalyzed Dana- effort to expand access to care for medically underserved populations by reimagining compassionate care. It also reinforces the Institute’s patient navigation program. Farber’s institutional self- the Institute’s campaign commitment to reflection on how we can apply deliver resources for a diverse workforce vulnerable populations, the program builds one-to- our expertise in cancer care and that mirror’s Boston’s communities. one connections with patients from the beginning community outreach to save more lives.” “We love that Dana-Farber offers the highest level of their journey transitioning from their community By year two, Lathan anticipates that the pilot of cancer care without boundaries. For many people, provider to Dana-Farber. navigator in the GI clinic will be integrated into its access to this care is unimaginable and beyond their With the Salice Foundation gift, Dana-Farber clinical operation, and planning will begin to hire reach, but with the support, guidance, and direction is launching a pilot patient navigation program, two navigators for the thoracic and hematologic provided by the patient navigator program more lives under the leadership of Christopher Lathan, oncology centers. The program will then include will be given hope,” said Susan Salice, president of the MD, MS, MPH, chief clinical access and equity genitourinary oncology, with a navigator assisting Salice Family Foundation. officer, and Magnolia Contreras, MSW, MBA, men from vulnerable populations with prostate The Institute’s patient navigation program was vice president of community health, starting with cancer. Increasing minority patient accrual in clinical created in 2005 to guide medically underserved gastrointestinal cancers. trials is a priority for Dana-Farber, and additional patients and their families through the complexities of Minority communities are disproportionately navigators will work across the Institute to provide cancer screening and care in a culturally sensitive way. represented among patients with GI cancers. Black specialized clinical trial navigation for patients Based on the original model of patient navigation for Americans are 20% more likely to develop colon participating in research. ■

Compassion inspires generous gift to lymphoma research and patient assistance Epigenetics or most of his career, Samuel Fleet “It’s a testament to the culture that’s has worked in the health insurance built at Dana-Farber. It’s state-of-the- F industry, and so he always knew art and first class.” of Dana-Farber by reputation. But it Impressed by his care team led by For decades, cancer research has wasn’t until he was diagnosed with Ann LaCasce, MD, MMSc—especially focused on genetic mutations, lymphoma in September 2019 that he his nurses, Chisom Ebele, RN, and experienced firsthand what it is like to Barbara Virchick, NP—Fleet and his but DNA is only part of the story. be a patient here. wife, Debra, knew they wanted to Epigenetics—changes in how “From the moment you drive in and find a meaningful way to express their talk to the valet, all the way through gratitude, and during their time at the DNA is processed by the cell— reception, through the nursing staff Institute, they were particularly moved can also cause cancer. Dana- and clinical staff—they’re just an by witnessing patients who needed amazing group of people,” said Fleet. financial assistance. Farber is leading the epigenetics And so, the Fleets made a gift of revolution in adult and pediatric $100,000 which will support lymphoma research led by LaCasce, and the Patient cancers, and your gift to The and Family Assistance Program under Dana-Farber Campaign will help us the direction of Deborah Toffler, MSW, translate our epigenetic discoveries LCSW, senior director of Patient Care Services. The gift also provides into new treatments for patients. powerful momentum to The Dana- Farber Campaign, a key priority of which is to increase access to care for the underserved. “The Fleets’ compassion for our patients has been evident throughout our time together,” said LaCasce. “This meaningful gift strengthens our REVOLUTIONARY SCIENCE REVOLUTIONARY join us: defycancer.org The Fleets' generous gift was inspired ability to deliver the most cutting-edge in part by their care team, led by Ann LaCasce, MD, MMSc. treatments to every patient who comes through our doors.” ■

10% of all designated gifts supports our Faculty Research Fund to advance Dana-Farber’s research mission SUMMER 2021 | Impact 5 ANNOUNCING

Pasquarellos pledge to advance cellular therapies research with $2 million gift

nstitute Trustee Ted Pasquarello Dana-Farber Campaign through its “Ted and Eileen’s continuous for Clinical Programs. “Our work in and his wife, Eileen, recently made support of two key cellular therapy philanthropic support over the years cellular therapies holds tremendous I a new gift of $2 million in support studies led by Soiffer and Jerome has kickstarted several early stage promise for countless patients, and this of cellular therapies research under the Ritz, MD, executive director of the projects,” said Soiffer, who also serves latest commitment will help accelerate direction of Robert Soiffer, MD, vice Connell and O’Reilly Families as chair of the Executive Committee our progress.” chair of the department of Medical Cell Manipulation The Pasquarellos have seen Oncology and chief of the Division of Core Facility. their seed funding pay off in Hematologic Malignancies. The first is research other projects, such as the The Pasquarellos’ involvement with into harnessing natural Pasquarello Tissue Bank, which Dana-Farber stretches back to the killer (NK) cells— has provided researchers with 1990s, when Ted was diagnosed with aggressive immune invaluable patient samples chronic myelogenous leukemia (CML). cells that can attack for more than 20 years. The He underwent treatment overseen disease cells at a Pasquarellos’ foresight is by Soiffer, which included a stem moment’s notice—to also evident through their cell transplant and a new drug called treat many forms of membership in the Dana- imatinib—known by the brand name cancer. The second Farber Society, which honors Gleevec—one of the earliest targeted project will leverage those who have left a legacy therapies available for CML that was a genetic weakness of to the Institute in their will, a gamechanger for cancer medicine. the common Epstein- estate plans, or through other Ted, who has been in remission since Barr virus (EBV) to deferred and complex assets. 2003, points to this experience as a develop a new class “When I look back over key motivator for funding early stage of T cells capable 23 years now, and I see some research that shows long-term promise. of treating B cell of the things that they’ve done “I was very fortunate to receive one malignancies. This and the dedication that they of the earlier drugs, and it has led us treatment, called CD4 have, I feel grateful,” said to support research that could help T-cell therapy, aims Ted. “They eat, sleep, and somebody in the future,” said Ted. to prompt a similar think constantly about how “Our donations always go to where we immune response as to help patients. We’re proud can make the biggest progress.” in EBV to potentially to provide the capital to make Ted and Eileen Pasquarello have supported cancer research at Dana- ■ The Pasquarellos’ new commitment eliminate cancer and Farber for more than 20 years. it happen.” provides powerful momentum to The prevent recurrence.

Gronk and Camille host successful Cobbs pledge renewed support Jimmy Fund Bingo Night for multiple myeloma research

ince 2005, Steve and Gail Cobb rewarding to watch brilliant scientists have dedicated not only their like Drs. Mitsiades and Richardson S philanthropic support, but also march the myeloma therapy football their time to further the research of down the field,” said Steve Cobb. Dana-Farber’s Constantine Mitsiades, “While much has been accomplished MD, PhD, and his colleagues studying over the past decade, there is still multiple myeloma. Their advocacy an incredible amount of work to be for the importance of research into done to get across the goal line for this chronic disease has helped bring treating myeloma and other cancers. awareness and inspire much-needed We encourage others to get involved funding over the years. and support the Dana Farber team any Recently, along with ongoing way you can!” support of clinical research led by Paul “The Cobbs’ continued faith in Richardson, MD, the couple pledged us has been very motivating,” said an additional $200,000 in support of Mitsiades. “This latest commitment Mitsiades, who is working to improve will help us continue our work treatments for multiple myeloma. A in combating drug resistance and portion of the gift will also fund the reducing treatment toxicities—all research of two senior post-doctoral to ensure that our patients have the fellows in Mitsiades’s lab: Ryosuke best possible quality of life during Shirasaki, MD, PhD, and Ricardo De and after treatment.” ■ Dana-Farber celebrated another successful Jimmy Fund Bingo Night on March Matos Simoes, PhD. This gift serves 12, this time hosted by four-time Super Bowl Champion Rob Gronkowski as a continuation of one of the Cobbs’ and model and television host Camille Kostek. The virtual, interactive event, earliest gifts in support of a fellowship “We believe strongly sponsored by OOFOS, was livestreamed on the Jimmy Fund Facebook page program at Dana-Farber, and comes and provided an opportunity for fans and supporters to interact with Gronk and at a time when the Institute has in Dana-Farber’s unique Camille while raising money for Dana-Farber’s lifesaving mission. All told, the pledged to further encourage the next ‘bench to bedside’ model event attracted more than 16,000 viewers and raised $67,000 for Dana-Farber. generation of researchers as part of The for developing and First launched in 2020 amid efforts to offer more virtual events to our community Dana-Farber Campaign. and continuing throughout 2021, Jimmy Fund Bingo Night has raised more than “We believe strongly in Dana- proving novel therapies.” $150,000 since April 2020, and provided hours of family fun for supporters from Farber’s unique ‘bench to bedside’ — STEVE COBB all over the country who can tune in and play along from home. ■ model for developing and proving novel therapies, and find it very

6 Impact | SUMMER 2021 Friendship, gratitude, and entrepreneurial spirit motivate lymphoma research endowment

rom the moment former Institute Trustee David will put the funds Alan Hirschfield met Arnold Freedman, MD, to the best use—they are F in 1996, he knew he had found not only his both brilliant leaders in new doctor, but a friend. Alan and his wife, Berte, the field.” knew Dana-Farber by reputation, and so when Alan The fund will be was diagnosed with lymphoma, the couple came named the Alan J. to Boston all the way from Jackson, Wyoming. Hirschfield Lymphoma Freedman impressed them so much with his Endowed Fund until compassion and expertise that they decided that he Freedman retires, at should oversee Alan’s treatment. which time it will be That was the beginning of a long and fruitful renamed the Arnold friendship between the Hirschfields and Freedman, Freedman, MD, and a long and fruitful lifetime of involvement with Lymphoma Endowed the Institute. In 2002, Alan was invited to join the Fund to honor the Board of Trustees, and for many years participated meaningful friendship in the Visiting Committee for Hematologic between the Hirschfields Oncology—now known as Dana-Farber’s Presidential and Freedman. Berte Hirschfield made a generous gift in honor of her late husband, Alan, and his Symposium—which Berte also joined and attends “I am deeply moved doctor, Arnold Freedman, MD. annually to this day. by this gift from Berte,” After Alan passed away, Berte wanted to honor said Freedman. “Alan a particular passion for startups, supporting young his legacy. She recently established an endowment to was a wonderful friend to me for more than 20 physician-scientists was a perfect fit. support lymphoma research conducted by early career years, and the Hirschfields have been truly valued “Over the years, when family members or close faculty, which will be overseen by her dear friends supporters of the Institute for just as long. This friends have had cancer, I suggest they go to Dana- Freedman and David Weinstock, MD, another endowment will be an incredibly important resource Farber where I know they will have the best care, for colleague who quickly bonded with the Hirschfields. for the Adult Lymphoma Program for many years to Dana-Farber treats every patient equally,” said Berte. Weinstock is a Lavine Family Chair for Preventative come.” “Their profound understanding of the most current Cancer Therapies at Dana-Farber. The fund supports the next generation of cancer protocols and their humane treatment of “It means a great deal to me, and I know it would lymphoma physician-researchers at the Institute, patients is unparalleled.” ■ mean a great deal to Alan,” said Berte. “I can’t think providing powerful momentum to one of the of a better way to honor Alan and Arnie than with pillars of The Dana-Farber Campaign: investing in this gift. I have great confidence knowing Arnie and exceptional people. For Berte, an entrepreneur with

The 300 Project forges ahead with Bliss gift Equal Access ith an interdisciplinary approach and philanthropic to Care W support, Dana-Farber Cancer Institute’s Bing Center for Waldenström's Macroglobulinemia is taking steps to defy this rare white At Dana-Farber, we believe blood cell cancer through the 300 that zip code, skin color, and Project, a tissue bank and sequencing effort. What started with a $260,000 income should not determine gift from Tim and Ginny Bliss in who is able to access treatment. 2020 has been bolstered with a new commitment of $250,000 to Your gift to The Dana-Farber better understand Waldenström's Campaign can help us reduce macroglobulinemia and uncover disease Zachary Hunter, PhD (above), leads subtypes. research supported by Tim and cancer disparities and broaden Ginny Bliss. This type of personalized, patient- access to the highest quality driven research has become a staple at Dana-Farber and is a priority of The from interesting data, which may care and clinical trials in our Dana-Farber Campaign, to approach lead to new treatment approaches,” most vulnerable communities. basic science projects through the lens Hunter continues. “Although these Because improving care for of real-time patient care. projects have the most interesting data, “We are looking at how cancer it’s difficult to get funding for them. the underserved improves care cells from patients who may not seem Without the generous support of the for us all. connected clinically may be utilizing Bliss family and the participating 300 the same networks through different patient volunteers, this project wouldn’t mechanisms,” explains Zachary Hunter, be possible.” PhD, one of the project’s leaders. Once all data from the 300 Project “By analyzing this data, we aim to has been analyzed, the team plans identify disease subtypes that suggest to make it publicly available and to which drugs might be successful in a develop simple diagnostic tools for EXTRAORDINARY CARE EXTRAORDINARY join us: defycancer.org particular subgroup of patients.” each subtype, bringing personalized “As a discovery project, we have medicine to a broader population of the opportunity to start new research patients. ■

10% of all designated gifts supports our Faculty Research Fund to advance Dana-Farber’s research mission SUMMER 2021 | Impact 7 ANNOUNCING

Phill and Liz Gross invest nearly $1.9 million to accelerate innovative new therapies to patients

he cornerstone of Dana-Farber Cancer extraordinary gift will support well-vetted projects that Over the course of 2020, Pipeline Accelerator Institute's mission is to ensure that innovative have high translational and commercialization potential, grants were awarded to Jennifer Brown, MD, PhD, T laboratory findings make their way to patient but require further preclinical study. To that end, Dana- director of the Chronic Lymphocytic Leukemia bedsides. The process of taking a scientific discovery Farber investigators submit proposals that are reviewed Center; Edward Chouchani, PhD; Michael Eck, MD, all the way to the clinic involves costly translational by an internal scientific committee, with finalists PhD; and Wayne Marasco, MD, PhD, all of whom work that isn’t typically funded by traditional research presenting their proposal to Dana-Farber’s business are validating technologies and therapeutics that grants. Trustee Phill Gross and his wife, Liz Cochary development council. Part of the Grosses’ funding will could have a profound impact on cancer care. Gross, PhD, recognized this barrier to patient impact. support new staff members to administer the program “This gift is an extraordinary investment in the “Dana-Farber is built on world-class research, but and guide investigators toward clinical impact. entrepreneurial spirit of our research community,” sometimes even the best projects need timely funding “We owe Phill and Liz an enormous debt of Solomon explained. “Our investigators’ discoveries to get them to the next stage of development,” gratitude. The research they are championing stands often lead to commercial interest from biotechnology said Gross. “My hope is that our philanthropy to make a real difference in the lives of our patients,” or pharmaceutical companies and this funding builds can shepherd some of these projects said Haigis. on our history of successfully moving our discoveries to market, where they can make a real into the world.” difference. We hope others will join us.” As a Trustee and chair of the The couple gave a total of Trustee Science Committee at $1,895,000 to Dana-Farber’s Pipeline Dana-Farber—as well as a health Accelerator, an initiative that aims to care investor with nearly 40 years’ launch the Institute’s most promising experience—Phill has an intimate preclinical discoveries into the understanding of how strategic translational space—a focus of the funding can catalyze visionary Institute’s ambitious comprehensive projects. His and Liz’s longstanding campaign. The program recently commitment to innovative cancer instated a new director, Ramasamy research has been instrumental to Sakthivel, PhD, MBA. navigating unforeseen challenges Under the purview of the Belfer through the Emergency Response Office for Dana-Farber Innovations led Fund, accelerating life-changing by Lesley Solomon, senior vice president Under the purview of the Belfer Office for Dana-Farber Innovations led by Lesley Solomon breakthroughs in the lab and clinic, for innovation and chief innovation (left) and supported by Kevin Haigis, PhD (right), an extraordinary gift from Institute and relentlessly pursuing Trustee Phill Gross and his wife, Liz Cochary Gross, PhD, will advance projects with high ■ officer, and supported by Kevin Haigis, translational and commercialization potential that require further preclinical study. a cancer-free future. PhD, chief scientific officer, this

Costa Family makes a gift to Extra Mile Brunch celebrates help end childhood cancer walkers and national award hen Joe and Mary Costa W were deciding where to give back, the choice was simple. Joe’s father and brother were both treated at Dana-Farber, and he was able to see firsthand the high-quality patient care that the Institute is known for. Though Joe’s father and brother both passed away, the Costas felt a connection to and appreciation for Each March, participants in the Boston Marathon® Jimmy Fund Walk Dana-Farber, and they presented by Hyundai gather at the Extra Mile Brunch to celebrate the past knew they wanted to do Joe and Mary Costa are paying it forward with a year’s fundraising success. The 2020 Jimmy Fund Walk: Your Way was a whatever they could to generous gift to support pediatric cancer research virtual event and the 2021 Extra Mile Brunch followed suit, with over 600 help Dana-Farber reach a and care at Dana-Farber. participants joining the online festivities on March 14. world without childhood Susan Leader (above) received the Extra Mile Award for going above and cancer. The Costas’ support for Dana-Farber beyond in her 28 years as Team Captain of Jason & Mo Friendship Fund. “My wife and I decided to donate and the Jimmy Fund’s mission comes at Awards were also presented to First Time Walker of the Year Arianna Raso of to Dana-Farber because we have a time when the Institute has recently Arianna’s Army; First Time Team Captain Roger Dawley of Emma’s Angels; been very fortunate in having three launched The Dana-Farber Campaign Alumni Walker of the Year Marty Geoghegan of Zach’s Pack; Alumni Team children and seven grandchildren, and to accelerate progress toward a world Captain of the Year Esther Morales of Fernando’s Fight; and to Team Ovations all have been extremely healthy,” said without cancer—to defy cancer so that and Team Darby for Lifetime Achievement. Joe. “Other families have not been no child must manage cancer treatment It was also announced that the 2020 Jimmy Fund Walk: Your Way was that fortunate, and we think it is our while managing growing up. “We hope honored as a Program of the Year by the Peer to Peer Professional Forum, obligation to help knowing if we were that this donation will help to end a prestigious national award recognizing the hard work, dedication, and in their situation, we would have help childhood cancer. Children especially generosity of the Walk’s participants and supporters. Congratulations to all! ■ from them. We are just trying to pay it should have a chance to live the life our forward.” family has been able to,” said Joe. ■

8 Impact | SUMMER 2021 Palm Beach community raises more than $1.6 million and holds virtual event

n February 18, more than 200 contribute to this progress. Laurie supporters of the Palm Beach H. Glimcher, MD, president and Ocommunity gathered virtually CEO, shared her appreciation for the to participate in Dana-Farber Cancer Palm Beach community and gave an Institute’s premier event “Cocktails exclusive preview of The Dana-Farber and Conversation with Our Doctors.” Campaign. Graciously chaired by Institute Trustees Dana-Farber physician-scientist Phyllis Krock and Judie Schlager, Dana- speakers included Kenneth Anderson, Farber doctors and researchers discussed MD, director of the Jerome Lipper the latest cancer discoveries and research Multiple Myeloma Center and LeBow advances at the Institute. In addition to Institute for Myeloma Therapeutics, and the event, the Palm Beach community the Kraft Family Professor of Medicine; raised more than $1.6 million through Judy Garber, MD, MPH, chief of a special appeal to support lifesaving Cancer Genetics and Prevention and cancer treatments and groundbreaking the Susan F. Smith Chair; Christopher research discoveries for patients around Lathan, MD, MS, MPH, chief clinical The premier Palm Beach virtual event was chaired by Institute Trustees Phyllis Krock the world. access and equity officer and associate (left) and Judie Schlager. The event kicked off with remarks medical director of the Dana-Farber from legendary singer-songwriter and Network; Robert J. Mayer, MD, The evening’s vice chairs were Roberta and Stephen R. Weiner. member of the Rock & Roll Hall of faculty vice president for Academic Institute Trustee Harvey Berger and The virtual event was produced by Fame James Taylor and his wife, Kim. Affairs and the Stephen B. Kay Family his wife, Chrysanthi, Phyllis and Paul Bryan Rafanelli. At the top of the evening, alongside Professor of Medicine; Kimmie Ng, Fireman, and Institute Trustee Michele The night ended on a bright note Kim and their son, Harry, Taylor gave MD, MPH, director of Young-Onset Kessler and her husband, Howard. The as Taylor performed “Shower the a heartfelt performance of “You Can Colorectal Cancer Center and director co-chairs were Bruce Beal and Frank People” and attendees sang along. Just Close Your Eyes.” of Clinical Research in the Center for Cunningham, Dana-Farber Society before the performance began, Kenneth During the conversation portion Gastrointestinal Oncology; and Eric P. member Rose Dana and her husband, Anderson, MD, offered a moment of of the night, Dana-Farber’s physician- Winer, MD, chief clinical development Institute Trustee and Dana-Farber gratitude when he said, “Your heartfelt scientists elaborated on what excites officer, senior vice president for Medical Society member Charles Dana, Judy commitment, kindness, and support them about the future of cancer Affairs, chief of the Division of Breast and Jim Harpel, Institute Trustee Sandy of our clinical and research efforts research and care, and how the Palm Oncology and the Thompson Chair in Krakoff, Vicki and Arthur Loring, Tom represents the epitome of caring for one Beach community continues to Breast Cancer Research. Quick, Institute Trustee Jean Sharf, and another and helping those in need.” ■

Corcorans honor their son as members of Jimmy’s Team Dana-Farber Chairs

The innovations for which Dana-

In 2016, Bob and Tracy Corcoran’s Farber is renowned happen 11-year-old son, Timmy, was diagnosed when our talented clinicians and with Hodgkin lymphoma. The family “Jimmy's Team is a researchers have the time and sought treatment at Dana-Farber’s way to provide hope Jimmy Fund Clinic, and after four tools they need to revolutionize and strength to those months of chemotherapy, Timmy was cancer research and care. Your declared cancer-free. Forever grateful facing a cancer for the lifesaving treatment and diagnosis.” gift to endow a Dana-Farber Chair compassionate care their son received, recognizes a distinguished faculty the Corcorans joined Jimmy’s Team, — TRACY CORCORAN member and provides the financial a special group of loyal donors who commit to automatic, monthly gifts support essential to pursuing to Dana-Farber and the Jimmy Fund, promising new ideas and spending in 2017. donations of any amount. Recurring “Hearing that your child has cancer gifts may be directed to a research more time on what matters most: is devastating—in many ways you area of the donor’s choosing or to our patients. feel powerless,” said Tracy. “Our family unrestricted funding, a strategic is forever grateful for the care our son priority of The Dana-Farber Campaign, received at Dana-Farber—care generous offering flexible support where it is donors ensured was available when we needed most. needed it. By joining Jimmy’s Team, “Jimmy’s Team is so much more we’re doing our part to make sure that than a monthly giving program,” said same level of care is always available to Tracy. “It is a way to join forces in EXCEPTIONAL EXPERTISE EXCEPTIONAL join us: defycancer.org patients and families like us.” providing hope and strength to those Jimmy’s Team members support facing cancer diagnoses.” ■ Dana-Farber’s mission with monthly

10% of all designated gifts supports our Faculty Research Fund to advance Dana-Farber’s research mission SUMMER 2021 | Impact 9 ANNOUNCING

Honoring a life through saving others

hen asked to describe under the direction of his colleague, Center’s pioneering studies into the his work, Dana-Farber Marc Vidal, PhD, director of the fundamental biological interactions W scientist David Hill, PhD, Center for Cancer Systems Biology that drive cancer. says a word that comes to mind is (CCSB). A significant portion of this funding “serendipity.” A chance conversation “Serendipity comes in a wide range will support talented CCSB trainees. in the hallway could lead to a new of guises. It’s not the kind of word Supporting and mentoring women in project, a colleague describing their you’d normally associate with bad science was a passion of Deborah’s, who research over lunch could spark a events, but the truth is that out of this mentored young people throughout collaboration—breakthroughs, he tragedy people got a chance to extend her career as a mathematician. The first says, are built through networks. their lives,” said Hill. “Deb, in her Deborah F. Allinger Fellow is Anupama In 2019, Hill’s beloved wife, own way, made a contribution to Yadav, PhD. Investing in early career Deborah Allinger, passed away cancer care.” researchers is also a strategic priority suddenly after an accident. In the Dana-Farber’s CCSB explores cancer of The Dana-Farber Campaign. aftermath, Hill and his daughter Lydia biology from a systems perspective— “We were all devastated by the searched for the right way to honor her in other words, how genes and gene news of Deborah’s tragic accident legacy. Deborah was an organ donor, products interact to form complex two years ago. We are dedicated to and when Hill learned that her liver cellular networks, perturbations of honor Deborah’s life through the use The Deborah F. Allinger Research Fund saved the life of a cancer patient, he which can lead to cancer. Under of this amazingly gracious gift. We supports critical work in the Center for thought again of serendipity. He soon Vidal’s leadership, the team will will never be able to thank Lydia and Cancer Systems Biology led by Marc Vidal, PhD. after established a fund in her honor to use this funding, which now totals Dave enough for their generosity,” support cancer research at Dana-Farber, more than $750,000, to advance the said Vidal. ■

Asciones support research today, for patients tomorrow

ike and Kate Ascione are longtime “I’ve always felt grateful that recently received FDA supporters of Dana-Farber through their for the care and treatment approval,” said Choueiri. M involvement with the Pan-Mass Challenge my father and other family “These breakthroughs were (PMC)—for more than 16 years, the family has members received at Dana- years in the making, and I’m ridden, volunteered, recruited people to join, and Farber. There’s this incredible grateful that the Asciones see Mike also serves on the PMC Board of Directors. balance between clinical care the value in our work and what The family has also experienced firsthand what and the personal side that it could mean for countless it means to have a loved one become a patient. means hope for people,” said patients in the future.” Several relatives have been treated here, including Mike. “Our hope is that we Enhancing early detection two of Kate’s uncles and Mike’s father, Frank. Sadly, will fund research that will and expanding treatment Frank lost his battle with stage IV micropapillary help the next Frank Ascione.” options are priorities of

bladder cancer. Over their years of Mike Ascione (left) and his wife, Kate, give The Dana-Farber Campaign. In honor of the care that their family members involvement with the PMC, generously to Dana-Farber through the PMC “The dollars you put received, the Asciones established the Frank Ascione Mike and Kate have seen the in honor of Mike’s late father, Frank (right). toward research matter, and Genitourinary Cancer Research Fund with a technological advancements advancements made at Dana- $500,000 endowed gift made through the PMC. in cancer research—and the power that philanthropy Farber are leveraged around the world,” said Mike. The gift supports a range of research endeavors, from can provide to make it happen. “We are in a race to continue to drive cancer treatment, basic science to early phase clinical trials led by Toni “In the past year alone, the Lank Center has and Kate and I are grateful to have the opportunity Choueiri, MD, the Lank Center for Genitourinary moved forward on several key advancements, to honor Frank Ascione and advance critical Oncology director and the Jerome and Nancy including refinement of an early detection blood genitourinary research in his name.” ■ Kohlberg Professor of Medicine. test for kidney cancer and a new combination therapy

Imagine a World without Cancer To learn more about The Imagine Add your name, or that of a loved one, to The Imagine Display, made Display and one-of-a-kind naming possible by the Lucchino Family. Make a contribution that supports options, visit ImagineDisplay.org Dana-Farber’s lifesaving mission and choose an element in the periodic table, a star in the sky, a Boston landmark, or much more.

10 Impact | SUMMER 2021 Helen Gurley Brown Foundation renews initiative, launches support for trailblazing women at Dana-Farber

to the next level, further cementing their leadership in aggressive, late-stage form of prostate cancer that their respective field. The inaugural recipients, Himisha currently has no approved therapies. With this new Beltran, MD, and Kira Bona, MD, MPH, will use the funding, Beltran aims to explore the use of T cells funding to advance their important work in developing to target the protein DLL3 expressed on the surface new treatments for prostate cancer and identifying of NEPC cells, and to develop effective combination novel epigenetic changes driving pediatric cancer treatment strategies. Her research will be crucial to disparities, respectively. developing combination therapies for patients who “We are delighted to partner once again with have developed resistance to treatment. Dana-Farber Cancer Institute to further our mission Bona is studying the biological impact of poverty of inspiring and mentoring future generations of on pediatric B-cell acute lymphoblastic leukemia. women leaders,” said Eve Burton, president of Her data over the last decade demonstrates that the Helen Gurley Brown Foundation. “The newly children with cancer who come from low-income The Helen Gurley Brown Foundation, established launched Helen Trailblazer Awards are emblematic families experience higher rates of relapse and as The Pussycat Foundation in 2010 by longtime of our commitment to empowering women with the decreased overall survival compared to children from Cosmopolitan magazine editor-in-chief Helen Gurley resources they need to thrive.” non-low-income families when treated on the same Brown, recently renewed its support for Dana-Farber Beltran is studying the biology of small cell clinical trials. With this funding, Bona will explore by funding two programs aimed at empowering neuroendocrine prostate cancer (NEPC)—an whether physiological responses to poverty-associated women in science with a grant of $2,350,000 for 22 stress result in cancers that are more resistant to women faculty and fellows. chemotherapy. The first of these programs is The Helen Gurley “The current approach to disparities research in Brown Presidential Initiative, launched in 2016, which “The newly launched Helen pediatrics is to consider social and behavioral risk pairs senior women faculty and women fellows for Trailblazer Awards are factors as targets for intervention,” said Bona. “This two years, providing an opportunity for early career study challenges that paradigm and has the potential scientists to benefit from the mentorship of senior emblematic of our commitment to change our approaches to therapy.” scientists who understand the unique challenges faced to empowering women with the Since 2016, the Helen Gurley Brown Foundation by women in academic medicine. The new grant resources they need to thrive.” has provided more than $5 million in support supports 10 such partnerships. of women faculty and fellows at Dana-Farber. In 2020, the foundation expanded its impact with — EVE BURTON, president, Through The Dana-Farber Campaign, the Institute the newly established Helen Trailblazer Awards. This Helen Gurley Brown Foundation has prioritized faculty development and reducing program provides funding to women assistant and disparities in health care; donors like the Helen Gurley associate professors to propel their research and careers Brown Foundation ensure success in these areas. ■

A virtual gathering for Jimmy The Fund Golf Appreciation Night Defy Cancer Fund

We have made great strides in the fight against cancer, but we cannot rest on prior success and hope that progress will continue apace. Your unrestricted gifts, of any size, to The Dana-Farber Campaign’s

In a year full of challenges stemming from the COVID-19 pandemic, Jimmy Defy Cancer Fund accelerate Fund golfers showed resilience in their ability to adapt and continue raising success across the Institute— vital funds for Dana-Farber’s lifesaving mission. And their efforts did not go unnoticed—in March, Jimmy Fund Golf celebrated this incredible propelling innovative research, community at the first-ever virtual Golf Appreciation Night. Guests were treated to an evening of award presentations and special remarks in speeding new drugs into clinical recognition of their tremendous dedication—dedication that resulted in trials, meeting urgent and more than $4 million raised in 2020. unanticipated needs, and ensuring Speakers included Anne Gross, PhD, RN, NEA-BC, FAAN, senior vice president of Patient Care Services and chief nursing officer, and patient that patients receive the full speaker and tournament director Dave Worden, who shared how his measure of our Total Patient Care. experiences as a patient inspired him to start his tournament, the Dave Worden Classic.

“Dana-Farber has felt like family from the first moment we entered the Yawkey building. I told my wife I wanted to do something for this amazing place, and I wanted to do it while I was alive,” said Worden. “As a cancer ESSENTIAL OPPORTUNITIES join us: defycancer.org patient, I’ve never felt so much love and support from so many.” ■

10% of all designated gifts supports our Faculty Research Fund to advance Dana-Farber’s research mission SUMMER 2021 | Impact 11 ANNOUNCING

Gabrielle’s Angel Foundation A doctor's legacy advances fuels more vital research to gynecologic cancer research

mark 25th anniversary arilyn Seskin, MD, devoted her life to science and n 1996, Gabrielle Rich Aouad’s biology and cellular dynamics, has Mmedicine. When she was family created Gabrielle’s Angel been empowered by the foundation diagnosed with a rare form of ovarian I Foundation for Cancer Research to launch a study to better cancer in 2016, she turned to science with the mission to accelerate the understand how cells transition for answers, committed to doing what development of more effective therapies from one state to another—during she could to ensure other women for leukemia, lymphoma, and related development, for tissue maintenance, would not have to face her disease. disorders. In the 25 years since and in cancer progression. The team’s Though she passed away in 2019, Gabrielle passed away, the foundation work to reconstruct the genealogical Marilyn’s legacy lives on through has made progress possible by funding history of blood cancer cells using the Dr. Marilyn Seskin Fund for innovative scientific research and single-cell sequencing will help Gynecologic Cancer Research at efforts to elevate standards of patient answer questions about why the Dana-Farber, under the direction of care. Dana-Farber has been fortunate same genetic alteration can result in her doctor, Ursula Matulonis, MD, Marilyn Seskin, MD. to receive many years of support from drastically different forms of disease chief of the Division of Gynecologic the foundation, including its latest in different patients. With such Oncology. than $151,000 to gynecologic cancer $225,000 grant toward novel work critical funding, he and his team have “Marilyn’s life was a story of research and prevention. Her Trust being led by Sahand Hormoz, PhD. the potential to identify biomarkers perseverance. She believed that will also provide ongoing annual Hormoz, whose focus is in systems or key pathways that could lead to science held the answers and that support and secures future funding earlier diagnostic methods or new research was the way to find those for Marilyn’s fund. To commemorate drug targets, essential goals of The answers,” said Bob Sugarman, this special commitment, a research Dana-Farber Campaign. Marilyn’s husband. “She supported laboratory at the Institute has been “We are proud that together research so that, in her own words, named in her honor. with Dr. Hormoz, we are honoring no woman would have to suffer the “I’m very grateful to have received Gabrielle’s legacy and loving spirit way she did. Seeing her name given this meaningful gift from Marilyn,” by making important strides in to research to conquer the disease that said Matulonis, who is also the Brock- advancing progress and improving took her from us is her legacy.” Wilson Family Chair at Dana-Farber. Gabrielle's Angel Foundation continues clinical outcomes for cancer patients Finding cures for the most “Funding like this ensures that my to extend Gabrielle's remarkable legacy everywhere,” said Denise Rich, intractable forms of cancer is a priority team and I have the resources we need by helping to accelerate progress against cancer. Gabrielle’s mother and Founder, of The Dana-Farber Campaign, and to pursue cutting-edge research that Gabrielle’s Angel Foundation. ■ Marilyn’s foresight has provided more will save lives.” ■

Family’s fundraising contributes Paying it Forward4Tobi

to first global symposium for a obi Klonecki was warm, which make a tremendous, timely magnetic, and full of joy,” difference to patients and families rare and aggressive carcinoma T remembers Rebecca Linscott, experiencing financial distress.” president of the Forward4Tobi The rest supports the Presidential yan Richards was known among Foundation. Before she died in 2013 Initiatives Fund, a key priority of his family and friends for his at age 42, Tobi lived for four years The Campaign for Dana-Farber, and R sense of humor, enthusiasm with stage IV metastatic breast cancer is recognized with a consultation for life, and willingness to always (MBC). room in the Yawkey Center for lend a hand when needed. Ryan was Tobi made the best of her “new Cancer Care named in loving honor diagnosed with NUT carcinoma, a normal” with her children, husband of Tobi. She and Tom found their very rare and aggressive disease, and Tom, and loved ones, counting consultation room a warm and within months of being diagnosed herself lucky for having means comforting space that encouraged and shortly after the birth of his and a supportive community. She a human connection with their care daughter, Nora, he passed away at cherished friendships with fellow team. This meaningful tribute to the age of 40. To honor his memory, MBC patients—her “mets sisters.” Tobi honors her wish to ensure others his brothers Robbie, Michael, wife Saddened that financial hardship experience the same comfort. ■ Colleen, and a group of Ryan’s close hurt so many, she dreamed of friends founded The Ryan Richards paying forward her good fortune. Foundation in 2016. Ryan Richards with his daughter, Her husband and close friends Nora, and wife, Colleen. To date, the foundation has established the 100% volunteer-run donated more than $135,000 in Forward4Tobi to fulfill her dream support of NUT carcinoma research wife. “Ryan would help anybody. of helping women with breast under the direction of Ryan’s doctor, So in return, we want to help the cancer and their families focus Geoffrey Shapiro, MD, PhD, senior research at Dana-Farber, so that there on treatment and living life, by vice president of Developmental are more options for these patients supporting financial assistance for Therapeutics, and helped launch the and families.” needs like groceries, transportation to first International Symposium for The foundation was inspired by appointments, and rent. NUT Carcinoma which brought Ryan’s doctors and is motivated to In 2020, Forward4Tobi made gifts together doctors and researchers from continue fundraising on their behalf totaling $200,000 to Dana-Farber. around the world to discuss treatment at annual events on Cape Cod where A portion will provide crisis funds options and patient advocacy for this Ryan grew up and enjoyed summers. for breast cancer patients, especially The Forward4Tobi Foundation, represented by (from left) Dan Jacob, rare disease. These fundraisers include the Falmouth young mothers like Tobi. Senior Tom Klonecki, Karen Jacob, and Becky “I truly believe Dr. Shapiro is the Road Race (one of Ryan’s favorite road director of Patient Care Services, Foley at a check presentation in 2016, supports assistance for patients with reason Ryan was able to meet Nora,” races), a bike ride through Cape Cod, Deborah Toffler, MSW, LCSW, said, breast cancer. said Colleen McGrath Richards, Ryan’s and an auction/live music event. ■ “We deeply appreciate these funds,

12 Impact | SUMMER 2021 Donor honors her mother through support of groundbreaking tool to aid in early detection of ovarian cancer

or several years, Dipanjan team has been using this knowledge Chowdhury, PhD, chief of to develop a highly sensitive blood F the Division of Radiation and test that can detect early-stage Genome Stability at Dana-Farber, disease. has been working to improve early “Ovarian cancer detected early is detection tools for ovarian cancer. more curable, so the development Often referred to as a “silent” disease, of accurate and sensitive tests is ovarian cancer is typically asymptomatic an enormous priority for high- in its earliest, most treatable stages. risk families,” said Chowdhury, As a result, most women are diagnosed who also serves as co-director of with ovarian cancer when it is at an the Center for BRCA and Related advanced stage, at which point only Genes at Dana-Farber. “We have about a quarter of patients will survive seen tremendous progress over the for at least five years. last few years, and that’s thanks in For Veronica de Piante Vicin, these large part to supporters like Veronica statistics are personal. Her late mother, who believe in this work and what it Ana Maria Lolla, faced advanced could mean for countless women.” ovarian cancer twice in her lifetime, Early detection is a major priority and the disease unfortunately runs in of The Dana-Farber Campaign, and the family. Her mother was treated Veronica de Piante Vicin established a fund to support early detection research in honor Chowdhury’s research is the kind of her mother. overseas, with consultations from the of approach that could make that Dana-Farber care team, and during this goal a reality. But the faith that de time, de Piante Vicin resolved herself to helping spare “Dipanjan is just so passionate. He really believes Piante Vicin has in Chowdhury as a person represents others from the pain of ovarian cancer if she could. he is going to get there,” said de Piante Vicin. “He what makes Dana-Farber so special to so many: the When Ana Maria ultimately passed away in believes he’ll actually get the results that are needed brilliant, compassionate people behind the mission. 2014, that desire to help grew stronger. And when to help so many women.” “There’s a positivity about Dipanjan that’s de Piante Vicin was introduced to Chowdhury and Chowdhury and his colleagues discovered a specific infectious, that’s tangible, and my mother had the his research at Dana-Farber, she knew right away that set of 14 circulating microRNAs (miRNAs)—a type same positivity, even throughout treatment,” said de she wanted to get involved. In 2016, she established of molecule that helps cells control the kinds and Piante Vicin. “I think she would be immensely proud the Ovarian Cancer Early Detection Fund in honor amounts of proteins they make—in the blood of to know that it’s in her name and that this test could of Ana Maria Lolla. ovarian cancer patients. Over the last few years, his avoid a lot of the pain. She’d be very, very happy.” ■

Critical investment advances uterine cancer research Drugging “This new grant the Undruggable reflects our ongoing As part of Dana-Farber’s ambitious new campaign, the Lewin Fund commitment to to Fight Women’s Cancers made a Dana-Farber’s critical Dana-Farber is a leader in drug generous $100,000 gift to support gynecologic cancer development, playing a critical uterine serous carcinoma (USC) research under the direction of Joyce research.” role in nearly 1 of every 4 cancer Liu, MD, MPH, building on the — SHARYN LEWIN, MD, drugs approved by the FDA. Yet, Fund’s earlier $50,000 gift to support president and executive research by Panos Konstantinopoulos, director, The Lewin Fund we still don’t have drugs for many MD, PhD. Both gifts were made in targets—and some are termed memory of Mary Lou Ashford. This hard-to-treat subtype accounts inhibitor, which helps trigger increased “undruggable” because current for about 10% of uterine cancers but levels of DNA damage in cells, resulting treatments have no effect. Your gift up to 40% of deaths from the disease. in death of the cancer cells in patients to The Dana-Farber Campaign will “Even though uterine cancer is the with USC. As part of this effort, Liu most common gynecologic cancer in and her team are also studying patient help us to “drug the undruggable” the United States, with rising cases samples from the trial, as well as and develop next-generation annually, it is very underfunded,” said conducting simultaneous explorations Sharyn Lewin, MD, president and in research models, to try and pinpoint therapies for patients everywhere. executive director of the Lewin Fund. biomarkers that could predict how “This new grant reflects our ongoing USC cells might respond to WEE1. commitment to Dana-Farber’s critical “I am deeply grateful for the gynecologic cancer research.” Lewin Fund’s powerful investment in Leveraging the Lewin Fund’s our efforts to improve outcomes for most recent gift, Liu aims to better patients with uterine serous carcinoma, understand how defects in cellular which has the potential to provide new DNA repair mechanisms could be hope to those facing this devastating REVOLUTIONARY SCIENCE REVOLUTIONARY join us: defycancer.org exploited to sensitize cancer cells to cancer,” said Liu, associate chief and treatment. Liu is currently leading a director of clinical research of the clinical trial of a drug called a WEE1 Division of Gynecologic Oncology. ■

10% of all designated gifts supports our Faculty Research Fund to advance Dana-Farber’s research mission SUMMER 2021 | Impact 13 ANNOUNCING

Make-A-Wish honors 33 years of Decades of a sister’s support partnership with Dana-Farber for a cure and treatment

n 1993, Emily Sherwood’s sister, Daryl I Layzer, was diagnosed with multiple myeloma and sought care at Dana-Farber under Kenneth Anderson, MD, director of the Jerome Lipper Multiple Myeloma Center and Lebow Institute for Myeloma Therapeutics and Kraft Family Professor

of Medicine. Daryl Ned and Emily Sherwood. underwent a bone marrow and stem cell transplant— new and cutting-edge treatments at programs like these support Dana- ® Make-A-Wish Massachusetts and Rhode Island recently presented Dana- that time—which was facilitated by Farber’s best and brightest—a core Farber Cancer Institute with its 2021 Community Hero Award. The award Emily being an almost identical genetic part of The Dana-Farber Campaign. recognizes an organization or individual providing vital partnership in the match to her sister. Since the fellowship’s inception, the Make-A-Wish Massachusetts and Rhode Island mission of creating life- Through this treatment, Emily was Sherwoods have continued to support changing wishes for children with critical illnesses, and honors a 33-year partnership between the organization and the Institute. able to see firsthand the incredible this program, most recently with a care and expertise Anderson and his $200,000 gift. Dana-Farber President and CEO Laurie H. Glimcher, MD (above), received team provided. “Dr. Anderson has “We’ve had the opportunity to the award on April 10 at the Make-A-Wish® Gala: Heroes for Hope, a live won almost every major accolade in his meet many brilliant and dedicated virtual event. field, yet he is the most modest, self- scientists in Dr. Anderson’s lab, and “It is an honor to receive this award that recognizes Dana-Farber’s effacing, humble person we’ve ever met. it’s gratifying to know that there are commitment to create the best possible experience for our patients and their He cares about every patient as if he or so many great minds collaborating on families,” said Glimcher. “We are proud to work with community leaders like she were his own family member.” a cure for Multiple Myeloma,” Emily Make-a-Wish who share our devotion to patients facing cancer. It is inspiring After Daryl’s passing, Emily and says. “Although Daryl’s life was cut far for all of us at Dana-Farber to do our part to bring joy to a patient’s life as they make and fulfill their wish.”■ her husband, Ned, created the Daryl too short, it’s gratifying to help others Elizabeth Layzer Fellowship under live out their lives to the fullest extent the direction of Anderson. Fellowship possible.” ■

Hale Family continued from page 1 cancer is diagnosed and treated,” said Brian Wolpin, MD, MPH, director of together with Judy established a fund the Hale Family Center for Pancreatic The Hale Family Center for Pancreatic in 2007 to support pancreatic cancer Cancer Research and the Robert T. research. and Judith B. Hale Chair in Pancreatic Cancer Research The Hale Family’s commitment to Cancer at Dana-Farber. “We share their pancreatic cancer research and care deep commitment to ending pancreatic The Hale Family Center for Pancreatic Cancer and Hale Family Center for has continued across the generations. cancer, and the entire Hale Center Pancreatic Cancer Research include scientists exploring germline genetics, Judith Hale created the Hale Family team is exceptionally grateful for—and functional genomics, chemical biology, computational biology, cancer Center for Pancreatic Cancer in 2012, energized by—their trust and longtime metabolism, immunotherapy, and laboratory model system development, and with her son and daughter-in- financial support.”■ as well as clinicians specializing in medical oncology, radiation oncology, law, established the current Hale radiology, pathology, gastroenterology, and leadership of clinical trials. Family Center for Pancreatic This highly collaborative research environment has already had numerous Cancer Research in 2016. successes, including: In addition, the Hales’ company, Granite • Contributions to the first approval of a targeted drug for patients with Telecommunications, and its pancreatic cancer. employees have supported research at Dana-Farber and other • Creation of a comprehensive early detection program for patients with institutions by providing millions inherited risk of pancreatic cancer that is a national model. of dollars through corporate philanthropy and popular annual • Discovery of a new gene for inherited pancreatic cancer by studying events. pancreatic cancer-prone families. “I am inspired by the Hale’s determination and commitment • Detailed genetic studies that contributed to national guidelines which to the mission we all share,” said now recommend inherited genetic testing and tumor DNA sequencing Josh Bekenstein, chairman of the for all patients with a new diagnosis of pancreatic cancer. Board of Dana-Farber. “They are a model for others of the bold, • Completion of the most comprehensive map of the pancreatic cancer forward-thinking philanthropy immune microenvironment documented to date. that has meant so much progress for patients throughout Dana- • Establishment of one of the world’s most advanced clinical trials Farber’s history.” programs for pancreatic cancer. “With this extremely generous gift from the Hale Family, we Brian Wolpin, MD, MPH, leads the Hale Family Center for Pancreatic Cancer have an incredible opportunity Research. to transform how pancreatic

14 Impact | SUMMER 2021 Damon Runyon Cancer Research Foundation gives a boost to early career physician-scientists

including advancing prediction in diagnosis, conquering resistance and relapse, and accelerating progress in “The scientists we’re funding at Dana-Farber are pediatric cancers. taking translational, interdisciplinary approaches Elisa Aquilanti, MD, received the to answering urgent questions in cancer research.” For 75 years, the Damon Runyon Damon Runyon Physician-Scientist

Cancer Research Foundation has Training Award, established by the — YUNG S. LIE, PHD, president and CEO, Damon Runyon Cancer fueled the work of early career foundation to encourage physicians to Research Foundation physician-scientists poised to make pursue research careers by providing the next big breakthroughs in cancer an opportunity to train under the research. Named in honor of the mentorship of a senior physician- iconic sportswriter and journalist scientist. With the funding, Aquilanti is studying the mechanisms behind the goal of ultimately matching cancer Damon Runyon, is studying the role relapse in T-cell acute lymphoblastic patients with the best targeted treatment who passed away of telomerase—an leukemia (T-ALL)—an aggressive for their specific tumor. from throat cancer in enzyme hypothesized form of cancer in children and young “The scientists we’re funding at 1946, the foundation to be a key driver of adults that frequently stops responding Dana-Farber are taking translational, has invested more many cancers—in to treatment. Knoechel is working to interdisciplinary approaches to than $400 million glioblastoma and develop novel immunotherapies that can answering urgent questions in cancer in funding to over testing its efficacy as a overcome this problem and boost cure research. We’re excited by the promise 3,850 clinicians and new therapeutic target rates for high-risk patients. of their work and proud of our researchers around the for this particularly As a recipient of the foundation’s longstanding relationship with Dana- country. aggressive tumor. Quantitative Biology Fellowship Award, Farber and the breakthroughs it has To that end, Damon Birgit Knoechel, Collin Tokheim, PhD, is developing produced,” said Yung S. Lie, PhD, Runyon recently MD, PhD, received computational models that can identify president and CEO of the Damon

awarded $1,300,000 in With a generous award the Damon Runyon degradable proteins that are linked to Runyon Cancer Research Foundation. grants to three Dana- from the Damon Runyon Clinical Investigator cancer growth. Leveraging his expertise For more than 40 years, Damon Farber investigators, Cancer Research Award, which in computational biology, Tokheim Runyon has contributed valuable Foundation, Birgit each pursuing key Knoechel, MD, PhD, is supports investigators will utilize techniques from artificial resources to the Institute’s young strategic priorities of working to overcome conducting disease- intelligence, such as deep learning, to investigators pursuing the high- relapse in pediatric patients the Institute and The with T-ALL. specific research. With analyze the role of protein degradation risk, high-reward projects that spur Dana-Farber Campaign this award, Knoechel in thousands of tumor samples, with meaningful progress toward cures. ■

The Charles A. King Trust renews support for fellowships

he Charles A. King Trust body’s immune response to cancer— Postdoctoral Research Fellowship can be regulated to create new avenues Theranostics T Program, which supports for disease suppression. postdoctoral fellows and physician- “Drs. Wen Zhou, Hannah scientists in nonprofit academic, Uckelmann, and Shengqing Gu medical, or research institutions in represent researchers that are crucial Massachusetts, recently awarded grants to the continued medical advance- totaling $333,096 to three Dana- ment in the treatment of cancer,” Farber fellows. Established in 1936, the said Kimberly Lezak, managing Charles A. King Trust, aided by Bank director of The Medical Foundation Imagine if, with a single scan, we of America and its predecessor Banks, at Health Resources in Action. “We could simultaneously detect a which has served as Corporate Trustee look forward to seeing their continued throughout the trust’s history, was research success.” patient’s cancer and target it with created to promote the investigation These generous commitments will drugs that both diagnose and of human disease and the alleviation be counted among The Dana-Farber eradicate the tumors. That is the of human suffering through improved Campaign’s crucial gifts and provides treatment. The Sara Elizabeth O’Brien a springboard for innovative cancer promise of theranostics, an exciting Trust, Bank of America, N.A. Trustee, research and care. ■ new medical specialty being established in 1981 to support blindness and cancer medical research, pioneered at Dana-Farber. Your also funds awards through the King gift to The Dana-Farber Campaign Trust Fellowship Program. “[These researchers] could advance this radical new The Dana-Farber awardees are are crucial to the Shengqing Gu, PhD, the Sara Elizabeth approach to finding cancers early O’Brien Trust Postdoctoral Fellow, who continued medical and stopping their spread. is studying innovative treatments for advancement in the triple-negative breast cancer; Hannah treatment of cancer.” Uckelmann, PhD, MSc, who is studying the role of the protein menin — KIMBERLY LEZAK, in the self-renewal of leukemia to reveal The Medical Foundation at EXTRAORDINARY CARE EXTRAORDINARY join us: defycancer.org new therapeutic targets; and Wen Health Resources in Action Zhou, PhD, who is researching how the cGAS enzyme—which impacts the

10% of all designated gifts supports our Faculty Research Fund to advance Dana-Farber’s research mission SUMMER 2021 | Impact 15 ANNOUNCING

CALENDAR OF EVENTS For more information on all Jimmy Fund and Dana-Farber events and programs, go to JimmyFund.org or Dana-Farber.org

ALL SUMMER AUGUST 14 SEPTEMBER 17–19 Jimmy Fund Little League Swim Across America B.A.A. Half Presented by Franklin Sports Marathon® NEW VENUE for the Boston Harbor Open Water Swim: Castle Island at Pleasure Bay. We welcome swimmers of all ages and skill levels to Join Jimmy Fund Little League Run 13.1 miles for the Dana-Farber team in this year’s virtual support quality-of-life clinical research at Dana-Farber Cancer Institute. in its 35th season. Players B.A.A. Half, between September 17 and 19. Register to run, To register or donate, visit SwimAcrossAmerica.org/Boston. extend their baseball season support a runner, or learn more at RunDanaFarber.org or contact and take to their communities Ally Adolph at [email protected]. to raise vital funds for patient care and research. Visit JimmyFundLittleLeague.org or contact Robert Hendrickson at [email protected]. OCTOBER 3 Boston Marathon® Jimmy Fund Walk: NOW–JULY 31 AUGUST 19–22 ® Your Way Jimmy Fund Theatre Collections Jimmy Fund Scooper Bowl Presented by Hyundai Presented by Valvoline Instant Oil Change Hit the big screen and help fight cancer with the Jimmy Fund's longest- Take steps to defy cancer in your local community running fundraiser. Since 1949, participating movie theaters have shown The nation’s largest all-you-can-eat ice cream festival paused in 2020 in the annual Jimmy Fund Walk: Your Way —virtual once again in 2021. an exclusive Jimmy Fund "trailer" before the start of a feature film. Make to keep ice cream lovers safe. For 2021, we are bringing Boston’s favorite Register now or learn more at JimmyFundWalk.org or contact a donation to Dana-Farber and the Jimmy Fund when purchasing your summer tradition right to you! Purchase a Scooper Bowl-in-a-box ice Mary Perron at [email protected]. movie tickets or at DanaFarber.JimmyFund.org/ShowcaseforGood cream kit for pick up from locations around Greater Boston to enjoy while watching the movie. Contact Raquel Morales at safely at home, and support cancer research and care at Dana-Farber. [email protected]. Visit ScooperBowl.org or contact Jillian Davis at [email protected]. OCTOBER 8–11 Dana-Farber Marathon Challenge AUGUST 7–8 DFMC team members will cover the Boston Marathon® distance this Pan-Mass Challenge October, whether running the historic course or in their own neighborhoods. Apply to run, support a runner, or learn more at RunDFMC.org or contact Registration is open for the PMC, the Kelly Wicks at [email protected]. nation’s single most successful athletic fundraiser, which donates 100% of every AUGUST 24–25 rider-raised dollar to Dana-Farber. Routes from 25 to 211 miles , as well as Reimagined options, cater to all levels of WEEI/NESN cycling ability and fundraising capacity. Slots will fill fast, so register today at PMC.org. Commit—you’ll figure it out! Jimmy Find Radio-Telethon Presented by Arbella Insurance NOW–OCTOBER 15 Jimmy Fund Golf AUGUST 7–15 We're all Jimmy! Tune in to WEEI 97.3 FM and New England Sports Network (NESN) on August 24 and 25 to hear stories of hope and Challenge ASICS Falmouth inspiration from Dana-Farber patients, families, and clinicians. Road Race ASICS Help strike out cancer by making a donation during the broadcast, Join the Jimmy Fund Golf Challenge and which spans two Boston Red Sox games. Learn more at defy cancer with every swing. Fundraise in Run the Falmouth Road Race with Dana- JimmyFundRadioTelethon.org or contact Briana Lynch-Haddad support of cancer care and research to earn Farber's team this summer! Register for the virtual race August 7–14, at [email protected]. a tee time at the Cape Club of Sharon in with the chance of running the iconic 7-mile course in-person on August Sharon, Mass., on Monday, August 30. Visit 15. Visit RunDanaFarber.org for the latest race updates and to donate to JimmyFundGolfChallenge.org or contact a runner or contact Kelly Yardley at [email protected]. Victoria Fox at [email protected].

Impact | SUMMER 2021 | Volume 24 Issue 3

Impact is a newsletter of Dana-Farber Cancer Institute and President and Chief Executive Officer Chief Clinical Access and Equity Officer Vice President, Philanthropy Marketing the Jimmy Fund published by the Division of Philanthropy. Laurie H. Glimcher, MD Christopher Lathan, MD, MS, MPH Jan Lawlor Executive Vice President and Chief Operating Officer, Senior Vice President and Chief Integration Officer Associate Vice President, Campaign For questions, or to be removed from our mailing list, and Chair, Executive Committee for Research Elizabeth A. Liebow, MS Rebecca L. DuFault, MS please contact: William C. Hahn, MD, PhD Senior Vice President and Chief Administrative Officer Assistant Vice President, Philanthropy Communications Dana-Farber Cancer Institute & The Jimmy Fund Executive Vice President and Chief Finance and Maria Megdal, MHA M. Joyce Gallagher Division of Philanthropy Business Strategy Officer, and Assistant Treasurer Senior Vice President and General Counsel Impact Editors 10 Brookline Place West, 6th Floor Michael L. Reney, MBA John C. Ryan, Esq. Lori Dougherty, Colleen Sullivan Brookline, MA 02445-7226 Chief Medical Officer Senior Vice President and Chief Communications Officer Art Director 617-632-3019 or 800-52-JIMMY Craig A. Bunnell, MD, MPH, MBA Steven R. Singer, MPA David Ferreira or visit JimmyFund.org/opt-out Senior Vice President, Human Resources and Chair, Executive Committee for Clinical Programs Production Coordinators Chief People Officer Dana-Farber Cancer Institute provides expert, compassionate Robert J. Soiffer, MD Danielle Gray, Jessamyn Martin Heidi E. Conway, MS care to children and adults and is home to groundbreaking Senior Vice President and Chief Innovation Officer Contributors cancer discoveries. Since its founding in 1948, the Jimmy Fund Senior Vice President, Experimental Therapeutics Lesley Solomon, MBA Katherine Agate, Jane Anderson, Brian Bertoldo, George D. Demetri, MD has raised millions of dollars through thousands of community Chair, Executive Committee for Clinical Research Arielle Carlson, Jenna Cavanaugh, Caroline de Lacvivier, efforts to advance Dana-Farber’s lifesaving mission. Vice Chair for Clinical Affairs, Pediatric Oncology Mary-Ellen Taplin, MD Claudia de Piante, Scott Edwards, Brittany Flaherty, Lisa R. Diller, MD Julianne Heck, Bethany Herrema, Cyrena Musset, Chief Clinical Development Officer Dana-Farber and the Jimmy Fund share patient stories which Michael Quinn, Casey Reis, Casey Repasy, Kimberly Sheehan, Senior Vice President and Chief Philanthropy Officer and Senior Vice President for Medical Affairs may include descriptions of actual medical results. Dana-Farber Colleen Sullivan, Shannon Watterson Melany N. Duval Eric P. Winer, MD provides personalized care for each patient based on their Senior Vice President, Patient Care Services Photography unique needs; their experiences and results will vary. and Chief Nursing Officer Anne and Jason Farber Foundation, de Piante Family, Anne H. Gross, PhD, RN, NEA-BC, FAAN John Deputy, Rebecca DuFault, Berte Hirschfield, Julia Duresky/CAPEHART, Theresa Johnson Herlihy, Chief Scientific Officer Maddie Malhotra/Boston Red Sox, NBC Universal Media, LLC, Kevin M. Haigis, PhD Sam Ogden, Len Rubenstein, Sherwood Family, Chief Clinical Research Officer Bob Sugarman, Bryce Vickmark Bruce E. Johnson, MD

16 Impact | SUMMER 2021 We invite you to be a part of this extraordinary community as we embark on The Dana-Farber Campaign. You can help us in our mission to find effective treatment options for every patient, detect cancer earlier, and prevent cancer from even occurring. Every gift makes a difference. There is no time to waste. defycancer.org NON-PROFIT ORG. U.S. POSTAGE PAID NO. READING, MA Dana-Farber Cancer Institute & The Jimmy Fund PERMIT NO. 7500 Division of Philanthropy 10 Brookline Place West, 6th Floor Brookline, MA 02445-7226

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