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E N O yyyy A E S S S L T A E A C R C I yyyyN S M S E E H C C T N IO A Summer 2001 Vol. LXXIX, No. 10 yyyyC N • AMERI

NERM 2001 Program Places to Visit Eating Out

Book Review A Chemical History Tour by Arthur Greenberg

Short Course Pharmacology for Chemists October 10-12, 2001

Councilors’ Reports San Diego National Meeting Eastern Analytical Symposium

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2 The Nucleus Summer 2001 The Northeastern Section of the American Chemical Society, Inc. Office: Marilou Cashman, 23 Cottage St., Contents Natick, MA 01760. 1-800-872-2054 (Voice or FAX) or 508-653-6329. e-mail: [email protected] Chemistry at the University of New Hampshire ______4 Any Section business may be conducted by Clarence J. Murphy and Howard R. Mayne via the business office above. NESACS Homepage: http://www.NESACS.org NERM 2001 Frank R. Gorga, Webmaster Events, Programs ______5 Washington, D.C. ACS Hotline: 1-800-227-5558 Invited Speakers ______9 Officers 2001 Places to Vsit in the NH-Maine Seacoast Area ______13 Chair: Timothy B. Frigo Eating Out ______16 Advanced Magnetics, Inc. 61 Mooney St., Cambridge, MA 02138 617-497-2070x3007; [email protected] Short Course______15 Chair-Elect: Pharmacology for Chemists; October 10-12, 2001, Northeastern University Morton Z. Hoffman Chemistry Department, Boston University Boston, MA 02215-2507; 617-353-2494 ISOM XIV______18 [email protected] International Symposium on olefin metathesis; August 5-9 at M.I.T. Immediate Past Chair: Doris Lewis Chemistry Dept., Suffolk University Book Review ______18 41 Temple St., Boston, MA 02114 617-573-8546; [email protected] “A Chemical History Tour” by Arthur Greenberg, reviewed by Secretary: David L.Adams Michael Singer Sigma RBI 1 Strathmore Rd. Councilors’ Reports ______24 Natick, MA 01760-2447 Report on the Council Meeting on April 4, 2001, San Diego, CA 781-994-0523; fax:781-994-0677 [email protected] Treasurer: Historical Notes ______24 James Piper Simmons College, 300 The Fenway Boston, MA 02115, 617-521-2722 Cover: Thompson Hall, University of New Hampshire, Durham, NH Auditor: Anthony Rosner Deadlines: September issue: July 20, 2001 Archivist: Myron Simon October issue: August 29, 2001 20 Somerset Rd. Newton, MA 02465; 617-332-5273 [email protected] Trustees: Esther A.H. Hopkins, Michael E. Strem, Joseph A. Lima Councilors: Alternate Councilors: Term ends 12/31/2001 Term ends 12/31/2001 Thomas R. Gilbert Michael P. Filosa The Nucleus is distributed to the members of the Northeastern Section of the American Chemical Michael J. Hearn Morton Z. Hoffman Society, to the secretaries of the Local Sections, and to editors of all local A.C.S. Section publications. Arlene Wick Light Donald O. Rickter Forms close for advertising on the 1st of the month of the preceding issue. Text must be received by the Michael Singer Sophia R. Su editor six weeks before the date of issue. Term Ends 12/31/2002 Term ends 12/31/2002 Editor: Arno Heyn, 21 Alexander Rd., Newton, MA 02461, Mary T. Burgess Michael J. Dube Michaeline F. Chen Jean Fuller-Stanley Tel: 617-969-5712, FAX: 617-527-2032; e-mail:[email protected] Doris I. Lewis Patrick M. Gordon Associate Editor: Myron S. Simon, 20 Somerset Rd., W. Newton, MA 02465, Tel: 617-332-5273 Julia H. Miwa John L. Neumeyer Board of Publications: Marietta H. Schwartz (Chair), Patrick M. Gordon, Frank R. Gorga, E. Joseph Term Ends 12/31/2003 Term ends 12/31/2003 Billo (Consultant) Catherine E. Costello Arno H.A. Heyn Business Manager: Karen Piper, 19 Mill Rd., Harvard, MA 01451, William Klemperer Wallace J. Gleekman Tel: 978-456-8622 Truman Light(to12/31/01)Alfred Viola Dororthy J. Phillips Derk A. Wierda Advertising Manager: Vincent J. Gale, P.O. Box 1150, Marshfield, MA 02050, Tel: 781-837-0424; FAX: 781-837-8792 All Chairs of standing Contributing Editors: Mukund Chorghade, Patricia Hamm, Features; Edward Atkinson, History of Committees, the editor Chemistry; Maryann Solstad, Health; Dennis Sardella, Book Reviews; Marietta H. of THE NUCLEUS, and Schwartz, Software Reviews; E. Joseph Billo, Puzzles. the Trustees of Section Calendar Coordinator: Donald O. Rickter, e-mail: [email protected] Funds are members of the Proofreaders: E. Joseph Billo, Donald O. Rickter, M.S. Simon Board of Directors. Any Webpage: Webmaster: Frank R. Gorga, [email protected] Councilor of the American Chemical Society Asst. Webmasters:Terry Brush, [email protected] residing within the section area is an ex officio Kurt Heinselman, [email protected] member of the Board of Directors. Copyright 2001, Northeastern Section of the American Chemical Society, Inc. The Nucleus Summer 2001 3 Corporate Patrons Chemistry at the University Alfa Aesar, a Johnson Matthey Com- pany of New Hampshire Hoechst Marion Roussel Co. Pharm-Eco Laboratories, Inc. Clarence J. Murphy, 1888 was appointed Professor of Physical Sciences, Inc. Professor Emeritus, Department of Chemistry in 1891 and took over many Polaroid Corporation Chemistry, East Stroudsburg Univer- of Morse’s teaching duties. Strem Chemicals, Inc. sity of Pennsylvania During this period the department Corporate Sponsors Howard R. Mayne, and the college continued to grow. The Aerodyne Research, Inc. Department of Chemistry, University first foreign student at the college AstraZeneca R&D of New Hampshire received a degree in chemistry in 1886 Borregaard Synthesis, Inc. and the first female student, chemistry Bristol-Myers Squibb The Hanover Years major, Lucy Swallow, was admitted in Cambridge Isotope Labs The University of New Hampshire 1891. The first B.S. degree in chem- Consulting Resources Corporation traces its origins to the acceptance of istry was awarded in 1893. The first Dike, Bronstein, Roberts & the Morrill Act by the New Hampshire B.S. research thesis was by C. L. Hub- Cushman, LLP Legislature in June 1866. This led to bard (1893), entitled “The Soldering of Houghton Chemical Corp. the establishment of the New Hamp- Aluminium”. (The British spelling is shire College of Agriculture and typical of several of the early research JEOL, USA, Inc. Mechanic Arts in Hanover, in associa- theses in the department.) MassTrace, Inc. tion with Dartmouth College. The first New England Biolabs faculty member of the college in 1868 Conant Hall and the Move to Organix, Inc. was Ezekiel W. Dimond, who was Durham Pfizer, Inc. appointed professor of general and While the New Hampshire College of Research Biochemicals Int’l applied chemistry. An 1865 graduate of Agriculture and Mechanic Arts was Zymark Corporation Middlebury College, Dimond was syn- still located on the campus of Dart- onymous with the institution in its mouth College at Hanover, the State of New Hampshire was bequeathed the $40,000 to house the Department of early days. Not only was he professor Chemistry and other science depart- of chemistry, he was also the business entire fortune of a Durham farmer, Benjamin Thompson. He specified that ments. Conant Hall is now one of the manager, architect, supervisor of con- three surviving original buildings of struction, and lobbyist in the state leg- an agricultural college be founded on his property in Durham. The state UNH at Durham. islature. His efforts led to the In 1906 the first Master of Science construction of Culver Hall, which accepted the bequest and in 1891, preparations began for the college to degree in Chemistry was awarded to contained a chemistry laboratory, continued on page 10 described in 1874 as the only one in move to Durham. Charles Parsons the state. He also developed and taught designed the new chemistry laborato- courses in chemistry to students from ries in Conant Hall, which was con- New Hampshire College and Dart- structed during 1892-1893 at a cost of Footnote to mouth College. The Department of Chemistry is thus the only department “The Jungle that has existed for the entire history of the University of New Hampshire. Next Meeting Dimond served as professor of chem- Joint Meeting with the Rhode Story” istry until his untimely death, at the Island ACS Section In April, just after publication of “The Jungle Story” in the April issue of The age of 40, in 1876. September 13, 2001 Benjamin T. Blanpied succeeded NUCLEUS, Richard Schultes, the sub- Bristol Community College, ject of the story, died at age 86. He had Dimond as Professor of Chemistry and Fall River, MA head of the department in 1877. In been suffering from Alzheimer’s dis- 1889 Fred W. Morse succeeded Blan- Prof. Richard M. Stratt (Brown Uni- ease for some time and therefore pied as Professor of Chemistry and versity) will speak on his research on would not have been able to appreciate department head. In 1891 he was the dynamics of ultrafast processes in the story in the April issue, even if he appointed vice-director of the Agricul- liquids and the mechanism of solva- had received it. tural Experiment Station in addition to tion. He is survived by his wife in his duties in Chemistry. Charles L. Par- Details will be in the September issue Waltham who had provided details for sons, who had joined the department in the article.

4 The Nucleus Summer 2001 AMERICAN CHEMICAL SOCIETY 30th Northeast Regional Meeting June 24-27, 2001

The 30th Northeast Regional Meeting, hosted by the ACS The 2001 Industrial Innovation Awards Ceremony Northeastern Section, will be held in the Memorial Union will be held Tuesday at 6:00 PM in the Oak Room on cam- Building (MUB) at the University of New Hampshire, pus. Recipients will present a talk on their innovations dur- Durham, June 24-27, 2001. The meeting will feature general ing a special awards symposium at 1:30 PM that day. Poster sessions, topical symposia, and several workshops. exhibits and tabletop displays of the top innovations will be For information on registration and accommodation, in the exhibit hall throughout the meeting. The purpose of visit: www.unh.edu/chemistry/NERM or contact Howard this awards program is to recognize industrial chemists and Mayne, (603) 862-1550, email: [email protected]. chemical engineers in our region for their inventions and discoveries that have contributed to the commercial success of their companies and to the good of the community. Special Events The conference opens with a complimentary reception Honoring a UNH Colleague Sunday evening, June 24, at 6:00 PM in the Strafford NERM 2001 has two special events planned to honor one of Room of the MUB. its own: A symposium and dinner for Dr. Robert E. Lyle. On Monday, June 25, there will be a complimentary The Symposium to Honor Robert E. Lyle will take place luncheon and social event for Alpha Chi Sigma. Contact Monday, June 25 and Tuesday, June 26. The dinner will be Dr. Joe Geiser at [email protected] for more infor- held at the Three Chimneys Inn on Tuesday at 6:30 PM, and mation. reservations are required. Two Student Affiliate luncheon panel discussions Dr. Lyle served on the faculty of the University of New will be held. The first, on Monday, June 25, is entitled Hampshire from 1951 to 1977. During that period, his “After the BS”. Representatives from academia, industry, research group carried out work of outstanding quality. and government will answer questions on opportunities for Many of his former colleagues, students, and friends will be people who have – or soon will have — a baccalaureate on hand to pay tribute to this extraordinary man and his degree. The second, on Wednesday, June 27, will feature achievements. representatives from successful SAACS chapters across the region in a panel discussing Running an SA Chapter. Workshops The Northeast Regional Award for Excellence in The ACS Career Resource Center, featuring the Teaching High School Chemistry will be made Monday Regional Employment Clearing House (RECH), will offer night, 6:30 PM, in the Strafford Room. This year’s award career workshops and mini-sessions, résumé review will be presented to Susan M. Temme, who has taught at appointments, and a resource library, from Monday June 25 Cheshire High School in Cheshire, Connecticut since 1987. Ð Wednesday June 27, 8:30 AM Ð 5:00 PM. ACS members She began her career in 1973. Since 1990 she has served as and national and student affiliates interested in registering as coach and mentor of the Cheshire High School Chemistry job candidates may obtain information from the ACS Fax- Olympiad Team, and has received three Outstanding On-Demand service at 877-227-0505; the Career Services Teacher Awards—one from the University of Chicago and home page at www: acs.org/careers; or by phone at 800-227- two from MIT. An ACS officer will be the keynote speaker. 5558. Résumés will be accepted from candidates not able to A complimentary District Director’s Breakfast, attend the meeting. The deadline for returning registrations hosted by District I Director Anne O’Brien, will take place to the ACS Department of Career Services is June 11. Tuesday from 7:30 Ð 8:30 AM. All NERM 2001 attendees Employers interested in recruiting on site or posting are invited to hear about current Board actions and to voice positions in absentia may obtain registration and fee infor- any ideas, questions, and/or concerns about the ACS. In mation by contacting ACS Career Services at the aforemen- addition, sections celebrating significant anniversaries this tioned numbers. year will be honored at this breakfast. Frank Walworth, ACS Career Services will offer workshops covering the ACS Staff Coordinator for the ACS 125th Anniversary cele- components of managing an effective job search on Mon- bration this year, will present commemorative certificates to day, June 25 and Tuesday, June 26. There is no cost and no those local sections. During the meeting, Mr. Walworth will pre-registration is required. These sessions include Target- host a display of historical data, along with a special collage ing the Job Market (Monday 8:30 AM), Résumé Prepara- that was designed to capture the history of the ACS in an tion (Monday 9:45 AM), Interviewing Skills (Monday 11:00 encapsulated format, to commemorate the 125th anniversary. AM), and Career Transitioning (Tuesday 9:00 AM). In A complimentary barbecue lunch for all partici- addition, individual 25-minute résumé reviews will be pants will be held Tuesday at noon. offered from 8:30 AM Ð 5:00 PM on Monday through continued on page 6 The Nucleus Summer 2001 5 C3S is a service of the ACS Education and International Northeast Regional meeting Activities Division. Continued from page 5 The ACS Office of Research Grants and Awards will Wednesday. Bring a copy of your résumé. Appointments present a workshop on Writing Excellent Research Propos- will be made at the RECH registration desk. als Tuesday afternoon. On Tuesday afternoon, Morton A one-day workshop on Laboratory Safety will be Hoffman (Boston University) will conduct a hands-on held Sunday. In addition to an intensive review of the fun- workshop for teachers of general chemistry entitled New damentals of lab safety and effective lab safety programs, Strategies for the Teaching of General Chemistry. Attendees the program will cover: the scope of the problem; accidents; will examine the use of group activities, calculator-free legal aspects; planning for emergencies; handling, storage, exams and quizzes, reading and writing assignments, read- and disposal of chemicals; biological and animal hazards; ing notebooks, peer-led team learning, and performance- eye and face protection; disposal of chemicals; electrical enhancing techniques. safety, and safety program planning. Participants receive a There will be a one-day workshop on minority affairs 220-page seminar notebook and other handout materials. on Wednesday. In the morning session, JoAnn Moody of the The fee is $200 in advance or $250 onsite. New England Board of Higher Education and Sheila A workshop on Labworks¨ software will be held Browne of Mt. Holyoke College will present Faculty Men- Monday afternoon from 1:30 Ð 5:00 PM in Parsons Hall on toring and Departmental Good Practices: How to Retain the university campus. Also on Monday afternoon, Morton Non-Majority Students. The afternoon workshop, ACS Pro- Hoffman (Boston University) and Jerome Mullin (Univer- grams You Can Use to Attract and Retain Minority and sity of New England) will conduct an ACS College Chem- Younger Members, will be given by the ACS Department of istry Consultants Service (C S) Workshop. They will Diversity Programs. This session will inform participants of 3 the ACS programs available to increase departments’ enroll- discuss the range of consulting services available from C3S for two- and four-year colleges, and demonstrate to univer- ment, retention, and mentoring of minority and younger sity chemistry faculties and chairs how their departments members. might benefit from guidance, review, and/or assistance in Exhibits the development of new programs, ACS-CPT departmental More than 15 vendors will have displays in the exhibit area. accreditation and program certification, and revitalization. Exhibits will be open Monday and Tuesday. Vendors wish-

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6 The Nucleus Summer 2001 Registration Northeast Regional meeting On-site registration and distribution of program books Continued from page 6 and badges will take place on the 2nd floor landing of the ing to participate should contact Kathy Gallagher Memorial Union Building from noon until 6:00 PM on Sun- ([email protected]). day, from 7:30 AM Ð 5:00 PM on Monday and Tuesday and from 7:30 AM Ð 12 Noon on Wednesday. Travel & Lodging Advance registration forms are available online at: Directions to the conference can be found at the NERM http://www.acs.org/meetings/regional/calendar.html 2001 website listed earlier. Hotel and motel accommodation These must be submitted to the ACS Office of Regional is plentiful near the conference site, and contact information Meetings no later than June 3. Full payment, either check or is available at the website. credit card number, must accompany the form. Purchase Dormitory accommodations are available on the Uni- orders will not be accepted. Requests for refunds must made versity of New Hampshire campus. Reservations can be in writing to Evangelos Koutalas, ACS Office of Regional made at the website. Students can be accommodated for as Meetings, 1155 16th St. NW, Washington, DC 20036; little as $21 per night. (Certain restrictions apply). Other [email protected]. Full refunds will be issued until June rooms are available at a daily cost of $36.50 single and 3; between June 4 and June 23, a $20 processing fee will be $27.50 double. assessed. No refunds will be issued after June 23. The ACS Meetings Department has entered into an agreement with Association Travel Concepts (ATC) to help Special Events facilitate travel arrangements for attendees to the ACS Sunday meetings. ATC is a travel agency that works exclusively 4:00PM Ð 7:00 PM Ð Registration with the association market. In addition to providing reser- 9:00 AM - 4:30 PM Ð Workshop: Laboratory Safety vation assistance on our official air carriers, ATC will “fare 9:00 AM - 5:00 PM Ð Workshop: High School Teachers shop” all airlines to find the absolute lowest fare. To book reservations, or for more information about ATC, call 1-800- 6:00 PM - 8:00 PM Ð Reception and Mixer 458-9383 Monday American Airlines, Delta Air Lines, and US Airways 7:30 AM - 5:00 PM Ð Registration have been selected as the official co-carriers for the 2001 8:30 - 9:30 AM Ð Workshop: Targeting the Job Market ACS MEETING TRAVEL PROGRAM. All three carriers offer: 9:45 - 10:45AM Ð Workshop: Résumé Preparation ¥ 5% off any applicable published excursion domestic fares 11:00 AM - Noon Ð Workshop: Interviewing Skills (10% off if purchased 60 days or more before travel - spe- Noon Ð1:30 PM Ð Student Luncheon, “After the BS” cial conditions apply) 1:30 Ð 5:00 PM Ð Workshop: Labworks

¥ 10% off unrestricted coach fares (15% off if purchased 60 1:30 Ð 5:00 PM Ð Workshop: C3S days or more before travel - special conditions apply) 6:30 Ð 8:00 PM Ð High School Teacher Awards Dinner ¥ special domestic fares that are less than the unrestricted 7:30 Ð 9:30 PM Ð Poster Session I fares and do not require a Saturday night stay Tuesday To make reservations or for more information, call: 7:30 AM - 5:00 PM Ð Registration AMERICAN: 1-800-433-1790 from 7AM - 12 MID- 7:30 - 8:30 AM Ð District Director’s Breakfast NIGHT, EST 9:00-10:00 AM Ð Workshop: Strategies for Career Transi- Refer to Star File Number: 10079 tioning DELTA: 1-800-241-6760 from 8 AM - 11 PM, EST Noon -1:30 PM Ð Barbecue Lunch Refer to File Number: 157113A 1:30 - 5:00 PM Ð Workshop: Writing Excellent Research US Airways: 1-877-874-7687 from 8 AM - 9 PM, EST Proposals Refer to Gold File Number: 80191706 1:30 - 5:00 PM Ð Workshop: New Strategies for Teaching General Chemistry Avis and Hertz are offering discounted rates on rental cars for the 2001 ACS MEETING TRAVEL PROGRAM. To 1:30 - 5:00 PM Ð Industrial Innovations Awards Symposium make reservations, or for more information: 6:00 - 8:00 PM Ð Industrial Innovations Dinner AVIS: 1-800-331-1600 6:30 Ð 8:00 PM Ð Lyle Dinner Refer to ID Code: B923099 7:30 Ð 9:30 PM Ð Poster Session II HERTZ: 1-800-654-2240 Wednesday Refer to ID Code: CV 022M0293 7:30 AM -Noon ÐRegistration continued on page 8

The Nucleus Summer 2001 7 Northeast Regional meeting Oligosaccharide Synthesis Ð Peter Seeberger, Organizer Ultrafast Dynamics, II Ð Peter Weber, Organizer Continued from page 7 Symposium in Honor of Robert E. Lyle II Ð Gary Weisman, 8:30 AM - Noon Ð Workshop: Minority Recruiting and Organizer Retention I Contributed Papers:Organic Chemistry II; Analytical Noon - 1:30 PM Ð Student Luncheon, “Running a SA Chemistry I Chapter” Monday 7:30 Ð 9:30 PM Noon - 1:30 PM Ð NERM Steering Committee Meeting Poster Session I 1:30 - 5:30 PM Ð Workshop: Minority Recruiting and Retention II Tuesday 8:30 AM Ð 12:00 N Developments in Mass Spectrometry: Proteomics and Technical Program Glycomics I Ð Klaus Biemann and Bruno Domon, Monday 8:30 AM Ð 12:00 N Organizers Developments in Mass Spectrometry: Instrumentation Ð Reactive and Unusual Molecules I Ð Glen Miller and Bruce Reinhold, Organizer Richard Johnson, Organizers Advances in Polymer Delivery Systems and Composites Ð Clusters: From Molecules to Nanomaterials I Ð Olof Echt Yvon Durant and Donald Sundberg, Organizers and François Amar, Organizers Reversible Molecular Interactions Ð Thomas Laue, Orga- Symposium in Honor of Robert E. Lyle III Ð Gary Weisman, nizer Organizer Symposium in Honor of Robert E. Lyle I Ð Gary Weisman, Advances in Synthetic Organic Chemistry I Ð Organizer Amy Howell, Peter Jacobi and Charles Zercher, Ultrafast Dynamics I Ð Peter Weber, Organizer Organizers Contributed Papers: Organic Chemistry I Topics in Microencapsulation and Polymer Chemistry Ð Yvon Durant and Donald Sundberg, Organizers Monday 1:30 PM Ð 5:00 PM Change in Chemistry Education I Ð Christopher Bauer, Advances in Polymer Analytical Techniques Ð Organizer Yvon Durant and Donald Sundberg, Organizers

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8 The Nucleus Summer 2001 Northeast Regional meeting Wednesday 8:30 AM Ð 12:00 N Functional Glycomics Ð Harry Schachter, Organizer Continued from page 8 Molecular Magnetic Systems I Ð Christopher Landee and Contributed Papers: Inorganic Chemistry I; Analytical Mark Turnbull, Organizers Chemistry II Advances in Synthetic Organic Chemistry IIIÐ Amy Howell, Tuesday 1:30 PM Ð 5:00 PM Peter Jacobi and Charles Zercher, Organizers Developments in Mass Spectrometry: Proteomics and Change in Chemistry Education II Ð Christopher Bauer, Glycomics II Ð Klaus Biemann and Bruno Domon, Organizer Organizers Reactive and Unusual Molecules III Ð Glen Miller and Reactive and Unusual Molecules II Ð Richard Johnson, Organizers Glen Miller and Richard Johnson, Organizers Contributed Papers: Physical Chemistry I Clusters: From Molecules to Nanomaterials II Ð Wednesday 1:30 PM Ð 5:00 PM Olof Echt and François Amar, Organizers Advances in Synthetic Organic Chemistry IV Ð Advances in Synthetic Organic Chemistry II Ð Amy Howell, Peter Jacobi and Charles Zercher, Orga- Amy Howell, Peter Jacobi and Charles Zercher, nizers Organizers Change in Chemistry Education III Ð Christopher Bauer, Contributed Papers; Inorganic Chemistry II; Other Organizer Chemistry Topics Molecular Magnetic Systems II Ð Christopher Landee and Tuesday 7:30 Ð 9:30 PM Mark Turnbull, Organizers Poster Session II Contributed Papers: Physical Chemistry II NERM 2001 Invited Speakers Charles C. Agosta, Clark University David Han, University of Connecticut Health Center Paul Anderson, DuPont Pharmaceutical Co. Thomas D. Harris, DuPont Pharmaceutical Co. William F. Bailey, University of Connecticut George A. Heavner, Centocor, Inc. John E. Baldwin, Syracuse University Preston Hensley, Pfizer, Inc. Joyce Bischoff, Harvard University loannis Houpis, Boehringer Ingelheim Emory Braswell, University of Connecticut Amy Howell, University of Connecticut Kimberly A. Briggman, National Institute of Standards and Shaw Ling Hsu, University of Massachusetts - Amherst Technology Peter A. Jacobi, Dartmouth College Joseph I. Budnick, University of Connecticut Mark Johnson, Yale University Kay M. Brummond, West Virginia University Richard P. Johnson, University of New Hampshire Mike Calter, University of Rochester James J. Kaminski, Schering-Plough Jennifer Campbell, PE Biosystems Amy Keating, Massachusetts Institute of Technology Ray Camphausen, Genetics Institute Larry K. Keefer, National Cancer Institute Susan Loughrey Chen, GlaxoSmithKline Joseph L. Knee, Wesleyan University Ashok Cholli, University of Massachusetts - Lowell Narayanan Kuthirummal, Brown University Daniel Comins, North Carolina State University Paul Lahti, University of Massachusetts - Amherst Chip Coty, JEOL Instruments John LaMattina, Pfizer, Inc. Shawn DeFrees, Neose Technologies, Inc. Christopher P. Landee, Clark University Ed Dix, Assumption College David Lemal, Dartmouth College Xiangfeng Duan, Harvard University Todd L. Lowary, The Ohio State University Richard I. Duclos, Jr., Boston University Medical School Claudio Margulis, Columbia University Rick Edmondson, Genomic Solutions Inc. John L. Marshall, Polaroid Corporation Christopher J. Fecko, Massachusetts Institute of Technology Roy Martin, Micromass James F. Garvey, SUNY-Buffalo Steve Martin, Perceptive Biosystems, Inc. Robert J. Goldschmidt, National Institute of Standards and Glen P. Miller, University of New Hampshire Technology Scott J. Miller, Boston College Nancy S. Goroff, SUNY-Stony Brook Pamela Mills, Hunter College Robert Gyurik, Bentley Pharmaceutical, Inc. Kathleen R. Mondanaro, St. Michael’s College Frank Hagelberg, Jackson State University continued on page 10

The Nucleus Summer 2001 9 which was presented to the University new building. Unfortunately he was Chemistry at UNH by ACS Past-President Paul Anderson never to see the building completed as Continued from page 4 (Ph.D., R. E. Lyle, 1963) reads: he died prematurely on December 10, William Robinson, a student of Par- “Beginning in 1906, in a laboratory in 1928. sons. When Fred Morse became direc- Conant Hall, Charles James (1880- Dr. Harold A. Iddles, a graduate of tor of the Massachusetts Agricultural 1928) devised novel fractional crystal- Michigan State College, who held a Experiment Station in 1909, Parsons lization techniques for separating rare masters from Iowa and a doctorate was appointed head of the department. earth elements, which were widely from Columbia was appointed the In 1907, Parsons had been appointed adopted by other chemists. James used sixth Professor and Head of Chemistry the secretary of the American Chemi- his method to separate large amounts in 1929. He supervised the move into cal Society. He held this office until of ytterbium, hitherto considered to be continued on page 11 1945. Thus from 1907 until 1911, a single element, into two elements when Parsons resigned to become now known as ytterbium and lutetium. When the simultaneous isolation of Invited Speakers Chief Chemist of the U.S. Bureau of Continued from page 9 Mines, Conant Hall was the headquar- lutetium was published in 1907 by Georges Urbain, James made no public James D. Morrison, University of New ters of the ACS. Hampshire From 1906 to 1928, Conant Hall claim for his own pioneering work. Despite his retiring nature, James was David Newberg, Kennedy-Shriver Cen- also housed the offices and laboratories ter of Charles James. On Parsons’ resigna- internationally recognized as an expert Pete O’Connor, Boston University Med- tion in 1911, James succeeded him as in rare earth chemistry. His highly ical School Professor and head of the department. purified rare earth specimens were in Under his leadership, the department demand by research laboratories James S. Panek, Boston University focused on the disciplines of inorganic throughout the world.” Joel Parks, Rowland Institute for Sci- ence and analytical chemistry. Under James, Charles James Hall Conant Hall and Durham became By the late 1920s, Conant Hall was no Obadiah J. Plante, Massachusetts Insti- tute of Technology known worldwide among chemists as a longer adequate to accommodate the center of rare earth research. needs of the department. In 1926 plan- John A. Porco, Jr., Boston University On October 29, 1999 Conant Hall ning began for a new and larger facility Fred Regnier, Purdue University was dedicated as an ACS National His- for the chemistry. James spent the next Bruce Reinhold, University of New toric Chemical Landmark. The plaque, two years working and planning for the Hampshire Christoph Rose-Petruck, Brown Univer- sity Maartin Protema, Wayne State Univer- sity Jason Rouse, Genetics Institute Joseph E. Saavedra, National Cancer Institute Martin Saunders, Yale University Harry Schachter, University of Toronto Charles A. Schmuttenmaer, Yale Uni- versity Larry Scott, Boston College Touradj Solouki, University of Maine Richard M. Stratt, Brown University Lawrence Thompson, Memorial Uni- versity Mark M. Turnbull, Clark University Richard Vachet, University of Massa- chusetts Nelly Viseux, Biogen Inc. Peng G. Wang, Wayne State University Hilton Weiss, Bard College Grant Yeaman, Dartmouth Medical College Charles K. Zercher, University of New Hampshire

10 The Nucleus Summer 2001 In 1961 the system of department lege of Life Sciences and Agriculture, Chemistry at UNH heads was changed to one in which and particularly to the Cooperative Continued from page 10 department chairs were elected from Extension Program and the Agricul- the new chemistry building, which was the faculty ranks for fixed terms by tural Experiment Station. Meanwhile, dedicated at the 1929 fall meeting of their colleagues. Under this system, though, the Chemistry Department has the Northeastern Section of the Ameri- Alexander R. “Sandy” Amell, Charles become extremely active in supporting can Chemical Society as Charles W. Owens, Clarence L. “Tiny” Grant, the state’s educational programs in sci- James Hall. Frank L. Pilar, Paul R. Jones, W. ence, involved in training science Professor Iddles expanded the Rudolf Seitz, and Howard R. Mayne teachers at all levels. Nowadays, as offerings in organic and physical have chaired the department. The well as the traditional B.S. and B.A. chemistry and increased the opportuni- department’s growth has leveled off degrees, undergraduates can work ties for upper level students to carry since the heyday of the 1960’s. State towards a B.A.C.P.T. (B.A. in Chem- out independent undergraduate funding for the university Ð never high istry and Physics Teaching). In addi- research projects. The Department was Ð has slipped in recent years. (New tion, the M.S.T. (Masters of Science in among the first to receive American Hampshire is one of the few states Teaching) is available for graduate stu- Chemical Society approval and the with neither a sales tax nor an income dents. The department has also been a power to confer ACS Certified Bache- tax.) However, the demands on pioneer in the Preparing Future Faculty lor of Science degrees in Chemistry. administrative time have, if anything, program, and continues to spearhead The M.S. continued to be the highest increased dramatically. Chairs now initiatives in the teaching of general degree offered by the department until have to cut through thickets of admin- chemistry, receiving national attention 1955, when the Doctor of Philosophy istrative red tape, keeping track of (and National Science Foundation degree program was instituted. The safety and employment regulations funding) for this work. first Ph.D degrees were granted in undreamed of in earlier days. The Uni- In 1993, Paul Jones organized a 1958, all to students of Robert E. Lyle. versity has become a Carnegie Doc- meeting to celebrate “A Century of toral Extensive institution, and as such, Iddles served as Professor and Head of Chemistry in Durham”. This meeting maintains a vigorous research effort. the department until his retirement in was attended by many with direct links The Chemistry Department is a key 1961. to the department’s past. Professor A. component in this effort, and can point Throughout the department’s exis- F. Daggett (1906-1999), a student of to the fact that all its faculty members tence several courses in engineering Charles James, was among them. He is remain active in research, in spite of were offered, because the department remembered fondly, as are many others was in the College of Technology. In sometimes daunting budget problems. In 1998, the first Research Faculty who have taught or studied here, by a 1938 a chemical engineering option memorial scholarship Ð the Daggett was introduced. In 1950, with the con- came to the department, adding an expertise in biochemical mass spec- Summer Undergraduate Research Fel- struction of Kingsbury Hall, a separate lowship. Thus, the names of those who Department of Chemical Engineering trometry. Chemistry at the University of helped build the institution can live on was created to administer this program. New Hampshire has also spread to the with future generations of students. A separate Department of Agricultural state’s largest city. The University of Parsons and James would be proud to and Biological Chemistry was also New Hampshire at Manchester has know that the department continues the established in the College of Agricul- offered courses in chemistry for over a tradition of requiring a research thesis ture. decade, but only this year hired its first from all its B.S. students. Parsons Hall and Iddles Auditorium tenure track faculty member. This summer, at NERM 2001, the The department occupied James Hall Another advance has been the University of New Hampshire invites until 1967, when Parsons Hall and the department’s recent initiatives in its colleagues from the ACS Northeast Iddles Auditorium were built to house recruiting and retaining US minority Region to its campus to showcase its the Chemistry Department laborato- graduate students. This has been recog- many facets. Most of the research ries, classrooms and library. It is inter- nized by awards and support from areas of the Chemistry Department esting to note that from 1866 to 1961 Glaxo SmithKline and the New Eng- will be represented. In addition, we the department was led by only six land Board of Higher Education. will celebrate the life and career of department heads, each of whom made Whatever the changes, however, Professor Robert E. Lyle, who taught a distinctive contribution the growth of one aspect of chemistry at the Univer- here from 1951 to 1977. The Chem- the department and the university. Four sity of New Hampshire remains con- istry Department has announced Den- of them, Ezekiel Dimond, Charles Par- stant. The commitment to the service nis N. Chasteen as its first Gloria G. sons, Charles James, and Harold Iddles of the community and the state remains and Robert E. Lyle Professor of Chem- were recognized for their contributions an essential one. The focus on agricul- istry. While the department continues by having buildings named in their tural outreach has shifted away from to face the many challenges of the honor on the Durham campus. the Chemistry Department to the Col- present, it keeps a respectful eye on its

The Nucleus Summer 2001 11 Northeastern University

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12 The Nucleus Summer 2001 Museum of Portsmouth), North Church, Gov. John Langdon House, Ye Places To Visit Olde Post Office/Custom House, John In The New Hampshire Ð Maine Seacoast Area Paul Jones House, Bulfinch Library, Other possibilities are given on the NERM website Rockingham Hotel, Rundlet-May http://www.unh.edu/chemistry/nerm/attractions.html House, Universalist Church, The Music Hall and the Portsmouth Area code (603) unless otherwise indicated. Athenaeum among others. Portsmouth All towns are in New Hampshire unless otherwise indicated. Chamber of Commerce Foundation. 436-1118. Start with the Seacoast Trolley for an centers offering 25 designer and name overview of Portsmouth. Summer brand outlets all located along Route 1 Portsmouth Livery Co. service throughout Rye and throughout the Kittery Outlet Shopping Historic tours of Portsmouth by horse- Portsmouth: Classic red trolley design district. drawn carriage. Departs from Market with brass and oak interior much like Square or by reservation. Portsmouth. Lake Winnepesaukee Area turn of the century trolleys minus the 427-0044. Beautiful lake, boat trips. Excellent tracks. The 17-mile narrated journey view from Mount Major (a moderate Prescott Park will pass Fort Constitution and Went- hike). Portsmouth, on the Piscataqua River, worth-by-the-Sea in New Castle and opposite the Portsmouth Naval Ship- Odiorne Point State Park in Rye. LL Bean in Freeport, Maine. yard (is it in Maine or New Hamp- Leaves Market Square every hour on A region which combines the quaint- shire? Only the US Supreme Court the hour. ness of a Maine village with upscale knows for sure!) Summer Arts Festival outlets and department stores, specialty American Independence Museum (436-2848) features local and imported stores and antique malls, inns, restau- Devoted to the story of US Indepen- talent in the warm evenings. rants and casual eateries. From dence. Portsmouth, take I-95 to the Maine Seacoast Repertory Theatre 1 Governor’s Lane, Exeter. 772-2622 Turnpike, Exit 9. Follow signs to I-95 Year round theatre company in historic Flag Hill Winery North and take Exit 17, 19 or 20 for building. Bow St. 433-4472. Yep, in New Hampshire. Visits, tasting Freeport. All of these Exits lead Strawbery Banke by appointment. directly to US Route 1. A 10 acre waterfront neighborhood and Route 155, Lee. 659-2949 NH Seacoast Cruises/Whale Watch- museum illustrating 350 years Garrison Hill Tower ing of architecture and social life through Climb 76 foot observation tower for Whale watching cruises daily at restored furnished houses, exhibitions, scenic views of White Mountains to 8:30am and 1:30pm. period gardens, traditional crafts the ocean. Free. Daylight hours only. Rt. 1A, Rye Harbor. 964-5545 and special programs. Marcy St. Abbey Sawyer Memorial Highway off Portsmouth. 433-1100. Old York Historical Society Central Ave. near hospital. Dover. Buildings showing life in the 17th and Wallis Sands State Beach Golf 18th centuries. Nice beach if you wish to avoid the Hickory Pond Inn & Golf Course York, Maine. Tues.-Sat.10:00am-5pm, crowds at Hampton. Sandy beach, 1 Stagecoach Road, Durham. 659- Sundays 1-5 p.m. (207) 363-4974. changing facilities, eatery, parking. 2227 Admission fee. Route 1A, Rye. Phillips Exeter Academy 436-9404 Rockingham Country Club Prestigious secondary school. Tour his- Exeter Road, Newmarket. 659-9956 toric campus including famous con- White Mountains temporary library designed by Louis Especially the Kancamagus highway Hampton Beach State Park (you show you’re from out of state if Sandy beach with boardwalk, food, Kahn, Phillips Church, Grainger Observatory and beautiful Georgian you say “Kancamangus”). The ranger showers and entertainment. Parking station gives information about hikes Ð fee in summer. Ocean Boulevard (Rt. architecture. 60 Front St. Exeter. 772-4311. Free. “Boulder Loop” is a good easy one. 1A), Hampton Beach. 926-3784. White Lake State Park is closer, and Isle of Shoals Steamship Co. Portsmouth Harbor Trail has a nice lake. Walking tour of historic downtown Narrated cruises to the Isles of Shoals Woodman Institute and Portsmouth Harbor plus Pis- sites includes the Moffatt-Ladd House, St. John’s Church, Warner House, Preserved 1675 Garrison house. Local cataqua River cruises. Portsmouth. historic exhibits. Excellent collection 1-800-441-4620 Prescott Park, Strawbery Banke Museum, Wentworth-Gardner House, of rocks and minerals, natural history Kittery Outlets Old South Meeting House (Children’s exhibits, Civil War artifacts, antiques. A collection of three separate outlet continued on page 14

The Nucleus Summer 2001 13 Children’s Museum of Portsmouth Follow 0.4 m take R on Pocahontas. Places To Visit Engaging hands-on exhibits, but plenty Just over bridge take R, follow signs Continued from page 13 of places to let off steam, too. 280 to Gate House. Go through gate. Located at 182 Central Ave. on the cor- Marcy St., Portsmouth. 436-3853 ($4.50/car+$2/passenger) Great place ner of Summer St. Dover. *Julia Reinhold (4) to explore! Excellent scuba diving. *Kyle Wang (15) Call for hours. 742-1038. Christa McAuliffe Planetarium http://www.starhop.com/ Hilltop Fun Center For Younger Families 3 Institute Drive, Concord. 271-7831. Miniature golf. Video arcade. Rt.108, (Look for the endorsements (*) by the *Endorsed by Andrew (age 15), Somersworth. “UNH Chemistry Kids”) Catherine (13) and Christina (16) 742-8068 Bayview Farms Horseback Riding Johnson and Victoria Mayne (15) *John Tomellini (11) 632 Bayside Rd., Greenland. 431-8221 Chuck E. Cheese’s Joker’s Family Fun N Games *Endorsed by Briana Bauer (age 13) Fun for the younger age group. Parents Video games and fun for rainy days. Canobie Lake Park can take out their frustrations with 2460A Lafayette Rd. (Rt. 1 S.), State-of-the-art amusement park fea- “Whack-a-Mole”. Portsmouth. 431-7770 tures 4 coasters, the Log Flume water 30 Fox Run Rd., Newington. 431-1367 *Jessica Miller (10) and Victoria ride called “The Boston Tea Party”, the *Miranda Miller(5) and Caitlyn Miller(2) Mayne (15) Timber Splash water coaster, a hand- Dover Bowl Odiorne Point State Park/Fort painted antique carousel, authentic Cosmic bowling. Central Ave., Dover. Dearborn steam train, giant skywheel, over a 742-8292 Footpaths and picnic areas along ocean dozen kiddie rides. From NH Sea- *John Tomellini (11) and Little Harbor. Explore the tide coast: Take I-95 South to Route 495 Durham Pool pools and visit the Science Center with South to Route 213 West to Route 93 its hands-on exhibits. Site also con- North to Exit 2 in Salem, NH. 893- If it’s hot, this is THE place to be. On the UNH campus. tains abandoned WWII era bunkers. 3506 Parking fee. Route 1A, Rye. 436-1552 *Nicholas Bauer (age 15), Briana Fort Foster *Victoria Mayne (15) Bauer (13), Victoria Mayne (15) and From I-95, take exit #2 At rotary take Kyle Wang (15) Rte 236 S. Becomes Rte 103. Follow Polka Dots Personalized Pottery 3.4 miles. Take R on Chauncy Creek. Decorate your own pottery. Appeals to all ages. 599 Lafayette Rd., Portsmouth. 427-1085 *John Tomellini (11) Roller Skate Newington Fox Point Rd., Newington. 431-2267 *Jessica Miller (10) Sandy Point Discovery Area The education headquarters of Great Bay National Estuarine Research Reserve. The site includes 50 acres of mixed-upland forest, freshwater wet- lands and extensive salt marshes, with access to all three habitats via a wheel- chair accessible 1700-foot boardwalk. Wednesday through Sunday, 10:00 am - 4:00 pm. 89 Depot Rd. (Off Rt. 33), Stratham. 778-0015 *Emma Weisman (18) Water Country Giant water slides and New England’s largest wave pool. Lazy River and Raging Rapids tube rides and, for the brave, the free-falling “Geronimo”. Rt. 1 S., Portsmouth. 436-3556 *Briana Bauer (13), Nicholas Bauer continued on page 16

14 The Nucleus Summer 2001 ACS SHORT COURSE Designed to improve the skills and marketability of practicing B.S., M.S., and Ph.D. chemists. The NESACS Committee on Continuing Education is pleased to sponsor this newly updated National ACS Three-Day Short Course, at a registration fee of about half of that charged at National and Regional ACS Meetings. PHARMACOLOGY FOR CHEMISTS This Short Course is designed for chemical scientists who have little or no formal training in physiology, pharmacology, or medicinal chemistry. Registrants should have a firm grasp of organic chemistry, and the equivalent of an introductory course in physical chemistry and biochemistry. DATES and TIME: Wednesday, Oct. 10, 2001; 8:00 a.m. Ð 5:30 p.m. Thursday and Friday, Oct. 11 Ð 12, 2001; 8:30 a.m. Ð 5:30 p.m. PLACE: Snell Library, Room 88, Northeastern University, 360 Huntington Ave., Boston, MA PROGRAM AGENDA: General Concepts and Principles of Pharmacology: Definitions and survey of the appropriate literature; Membrane models, ion channels, structure of liquid water and implications to pharmacology; Absorption and distribution of drugs Ð active and passive transport; Blood-brain barrier; Drug metabolism, storage and excretion; Enzyme induction; Drug-receptor interac- tions and theories of drug activity; Introduction to pharmacokinetics. Nervous System: Anatomy and physiology of the nervous system; Nerve impulse transmission. Autonomic nervous system: Autonomic physiology and pharmacology; Noradrenergic system Ð receptors, agonists, antag- onists, mixed acting drugs; Dopaminergic system Ð physiology, Parkinsonian syndrome; Cholinergic system Ð receptors, agonists, antagonists, acetylcholinesterase inhibitors, Alzheimer’s syndrome, other forms of cognitive dysfunction. Central nervous system drugs: Definitions; Aspects of CNS anatomy and physiology: Neurotransmitters and receptors: Antidepressants; Antianxiety agents; Mood stabilization; Antipsychotics; Sedatives and related agents. Analgesics and related agents: Definitions and testing methods; Placebo effect, Anti-inflammatory analgesics Ð the anti- inflammatory response, role of prostaglandins, survey of drugs in this category; “Coal tar” analgesics – possible mecha- nisms of action, metabolic aspects, toxicity; Opioid analgesics – survey of chemical types, “MPTP,” receptors, mechanisms of action, endogenous peptide analgesics. Cardiovascular Agents: Aspects of cardiovascular anatomy and physiology; Hypertension Ð physiology of blood pressure regulation, Renin/angiotensin system; Antihypertensive drugs Ð physiology and pharmacology; Arrhythmias Ð aspects of physiology, agents used and pharmacological mechanisms, physiology of muscle fiber contraction, ion channels; Myocar- dial ischemia (angina pectoris) Ð physiological aspects, drugs employed. INSTRUCTOR: Joseph G. Cannon, Emeritus Professor of Medicinal Chemistry, University of Iowa, has authored and co-authored over 200 articles in Organic Chemistry, Medicinal Chemistry, and Pharmacology. He is one of the highest rated instructors in the ACS Continuing Education program and is the recipient of the Smissman-Bristol-Myers-Squibb Award sponsored by the ACS Division of Medicinal Chemistry. PRE-REGISTRATION REQUIRED Ð Registration Fees: ACS Members if received before Sept. 26 ...... $500.00; after Sept. 26 ...... $575.00 Non-ACS Members if received before Sept. 26...... $600.00; after Sept. 26 ...... $675.00 There will be a limited number of scholarships for unemployed ACS Members on a space-available basis. Parking Fee $14.00/day University cafeterias will be available for lunches. For further information contact: Prof. Alfred Viola at (617) 373 2809 Registration form for Short Course: Pharmacology for Chemists Name:______Business Affiliation: ______Mailing______Telephone:______Address ______Mail with remittance to: Prof. Alfred Viola, Chair (Please make checks payable to NESACS. NESACS Committee on Cont. Ed. Sorry, we cannot accept credit cards or Department of Chemistry purchase orders.) Northeastern University Boston, MA 02115

The Nucleus Summer 2001 15 Portsmouth. 430-2154 Eating Out at The Seacoast Governor’s Inn* Other possibilities are given on the NERM website Built in 1920 for former NH Governor http://www.unh.edu/chemistry/nerm/attractions.html Huntley Spaulding. Accommodation and dining. All area code (603) unless otherwise indicated. 78 Wakefield St. Rochester.332-0107 All towns are in New Hampshire unless otherwise indicated. *Recommended by UNH Chemistry Department Library Restaurant* In the historic Rockingham House. Acorns Restaurant, New England tries. This is THE place to people Good food, and books to read while Center* watch. you wait. Contemporary American. Dramatic 14 Market Square, Portsmouth. 401 State St. Portsmouth. 431-5202 views. Pacing is leisurely; be warned if 430-9225 you are in a hurry. Café Mirabelle* Lindbergh’s Crossing 15 Strafford Ave. UNH campus, Excellent French food in a relaxed and Bistro and Wine Bar. Durham. 862-2815 informal atmosphere. Don’t be fooled 29 Ceres St. Portsmouth. 431-0887 Anthony Alberto’s Ristorante* by the small façade. Newick’s Excellent Italian. 59 Penhallow St. 64 Bridge St. Portsmouth. 430-9301 Some love it, some hate it. But you Portsmouth. 436-4000. Café Mediterraneo * should experience it once. Seafood. Banana’s Bar and Grill Good Italian food, good service, nice 431 Dover Point Rd. Dover. 742-3205 Dancing some evenings. atmosphere! Oar House* 172 Hanover St. Portsmouth. 431-5795 152 Fleet St., Portsmouth. 427-5563 Portsmouth harbor area with summer Barnacle Billy’s Cape Neddick Lobster Pound Har- riverfront deck. Upscale. Located directly on the harbor in borside Restaurant 55 Ceres St. Portsmouth. 436-4025 Perkins Cove, a famous artists’ colony Perched on the banks of the Cape Ned- Ogunquit Lobster Pound Restauran that boasts many shops and galleries. dick River. Guess what they serve! Perkin’s Cove, Ogunquit, ME. Shore Rd Cape Neddick, ME. (207) U.S. Route One, Ogunquit, ME. (207) (207) 646-5575 363-5471 646-2516 BG’s Boat House Restaurant Chiangmai* Old Ferry Landing Outdoor dining by the marina and an Thai. On the river overlooking the tugboats. air-conditioned dining room. 128 Penhallow, Portsmouth. 433-1289 10 Ceres St. Portsmouth. 431-5510 191 Wentworth Road Portsmouth. Chili’s Grill and Bar 431-1074 Portsmouth Gaslight Company* New England Mexican. 18 New Pub-style food, wood-fired brick oven Blue Mermaid World Grill Rochester Rd., Dover. 749-0939 pizza, and live entertainment. Very Interesting international variations on Ciento* popular with the 20-30 age crowd. grilling. Near the Sheraton. Tapas bar and restaurant. 64 Market St. Portsmouth. 430-8582 The Hill, Portsmouth. 427-2583 100 Market St. Portsmouth.766-8272 Porto Bello Ristorante Italiano Café Brioche* Dolphin Striker* Traditional Italian cuisine. Cafe Brioche Ð great coffee and pas- Upscale traditional New England din- 67 Bow St. Portsmouth. 431-2989 ing. Rosa Restaurant Places To Visit 15 Bow St. Portsmouth. 431-5222 Italian. A Portsmouth institution. Continued from page 14 Dunfey’s Aboard the John Wana- 80 State St. Portsmouth. 436-9715 maker* (15) and Victoria Mayne (15) Sake* On board the 1923 tugboat on the Pis- Japanese. 141 Congress St., York Wild Kingdom cataqua River. Portsmouth. 431- 1822 Exotic animals from around the world, Harbour Place, Portsmouth. 433-3111 Sakura plus a variety of family rides, paddle Foster’s Clambake* boats, an 18 hole miniature golf Japanese. New England clambake. 40 Pleasant St. Portsmouth. 431-2721 course, a petting zoo, scenic picnic Route 1A, York, ME. (207) 363-3255 grounds and even a Haunted House. Sheraton Harborside Hotel* Route 1, York Beach, Maine (207) Friendly Toast Has good restaurant and nightclub. 363-4911 Almost impossible to describe. 250 Market St. Portsmouth. 431-2300 “Quirky”, perhaps? 121 Congress St. *Julia Reinhold (4) Continued on page 17

16 The Nucleus Summer 2001 Eating Out Continued from page 16 Ship To Shore* Excellent, if a little out of the way. Route 108, Newfields. 778-7898. Three Chimneys Inn Newly restored in the original 1649 Ffrost-Sawyer homestead. 17 Newmarket Rd. Durham. 868-7800 York Harbor Inn* Fine dining, inn, conference center and pub on historic York Harbor Rte 1A, York, ME. (800) 343-3869 Thai Paradise* Excellent small family-owned Thai restaurant. 96 Bridge St. Portsmouth. 431-9193 Taipei and Tokyo* Sushi and Chinese. 1465 Woodbury NOTE TO PRINTER Ave., Portsmouth. 431-3662 Shalimar Indian Restaurant Mass Vac Indian cuisine. 80 Hanover St. Portsmouth. 427-2959 2/3 page ad appears here Watering Holes Benjamin’s Small bar. OK (if rather slow) food. Jenkins Ct. Durham. 868-6611 Ad # MASS 357 Crazy Cat Lounge Music for the younger crowd. Paper ad to be stripped in Congress St. Portsmouth. 430-0772 Hair of the Dog by Saltus Bar and bar food. Recommended by grad students (need we say more?) Main St. Durham. 868-9876 Molly Malone’s Irish pub upstairs, restaurant downstairs. 177 State St. Portsmouth. 433-7233 Portsmouth Brewery Brewpub. 56 Market St., Portsmouth 431-1115 Red Hook Brewery* Tours and tasting. Restaurant and out- let. Pease Tradeport, Portsmouth. 430- 8600 The Tin Palace The beer’s OK, I guess, and it’s close to the MUB. Ballard St. Durham. 868- 7456

The Nucleus Summer 2001 17 ISOM XIV Book Review 14th International Symposium on Olefin Metathesis A Chemical History Tour: and Related Chemistry Picturing Chemistry from Alchemy to Modern Molecular August 5-9, 2001, MIT The following are confirmed Science, By Arthur Greenberg speakers: Jean-Marie Basset, John Bercaw, (Dean, College of Science and The Organizing Committee is pleased Maurice Brookhart, Michael R. Buch- Engineering, U. of N.H.) to invite you to attend the 14th Interna- meiser, Uwe Bunz, Christopher Cum- (Wiley-Interscience; 2000), tional Symposium on Olefin Metathe- mins, W. James Feast, Robert H. 312 pp., 0471354082; $59.95 sis and Related Chemistry (ISOM Grubbs, Amir H. Hoveyda, Thomas R. (hardcover) XIV) to be held at the Massachusetts Hoye, Ezat Khosravi, Toshio Masuda, Institute of Technology in Cambridge Steve Nolan, Jun Okuda, Richard R. Reviewed by David L. Adams (Boston), Massachusetts, from Sunday Schrock, Susannah Scott, Lawrence R. Department of Chemistry noon, August 5 through Thursday Sita, Franz Stelzer, Emma Thorn- University of Massachusetts, noon, August 9, 2001. This symposium Csanyi, Gerard van Koten, and Ken Amherst, MA 01003 follows that held in July of 1999 in Wagener. Kerkrade, The Netherlands. Richard R. Schrock The program will begin Sunday, In the preface to A Chemical History Massachusetts Institute of Technology August 5th with morning registration Tour, Arthur Greenberg states that “the Cambridge, MA and a welcoming brunch followed by purpose of this book is to treat you to a [email protected] afternoon lectures. Approximately 35 light-hearted tour through selected lectures (invited, contributed, and oral Amir H. Hoveyda highlights of chemical history,” and posters) will be presented. Boston College “this book is designed as a picture Please go to http://web.mit.edu/ Chestnut Hill MA book with sufficient text to explain rrs/isom for full conference details. [email protected] details and content.” He further states Early registration deadline is June 15, General inquiries should be addressed that the book “is meant to be skimmed 2001. to: [email protected] as well as read.” The author, I believe, has accomplished these goals. The book is well written, well referenced and indexed. The segments on pages 181 to 184 exemplify the pedagogical techniques used, the style, and the utility, of Greenberg’s book. First, the units are brief and, although grouped by topic and era, they stand alone. Second, the author makes connections among simi- lar events or concepts from different eras in the history of chemistry. Third, and this is perhaps the major strength of the book, he uses images to convey chemical history. In these three pages, he provides a common thread in the discovery of elements through the use of “chemical scalpels.” Fire, the first chemical scalpel, added the four ele- ments antimony, arsenic, bismuth, and zinc, to the nine known to the ancients. Sir Humphrey Davy used the voltaic pile, or, in Greenberg’s view, the “elec- trical scalpel,” to free alkali metals from their compounds. Glenn T. Seaborg used radiation to discover Continued on page 19

18 The Nucleus Summer 2001 for a course in the history of chemistry For instance, Greenberg’s analysis of Book Review is enhanced, however, by the inclusion the tenure file of Henry Cavendish on Continued from page 18 of a good index and many references. page 129 is funny, timely, and a com- transuranium elements in the 20th cen- The index, while acceptable, could mentary on the modern tenure decision tury. On page 182 a plate from Davy’s have been better if it included separate process. There are, however, instances 1812 book Elements of Chemical Phi- name and subject indices, and if the where the writing is unclear. For losophy, shows the voltaic pile Davy main index topics were expanded to example, on pages 27-31 the author used, along with the apparatus he used include subcategories. discusses the “Great Work,” yet it is to discover potassium. One of the pedagogical techniques never defined or described or noted in Greenberg effectively uses images used in the book that is very helpful in the index. Only one technical error not only to explain, but also to convey seeing historical parallels is that of was discovered, and that is undoubt- the thoughts and apparatus of the time. connecting the old with the new. For edly a typo. On page 121 the formula In fact, the single feature of this history example, on page 169 the explanation of samarium oxide is given as SmS. of chemistry that separates it from by Berthollet of the high concentra- Finally, the binding of the book is many others is the use of images to tions of soda on the shores of salt lakes poor; pages have already become develop the history of chemistry and in Egypt presaged the law of mass largely separated in the review copy I bring it alive. For example, the action and Le Chatelier’s Principle. used. description of the Atomic Paradigm by Also, the modern notion that anti- Overall, my history of chemistry Dalton revolves around three plates cancer agents poison cancer cells more bookshelf is enriched by the presence from Dalton’s A New System of Chemi- rapidly than normal cells is quite simi- of Greenberg’s book. I will read it cal Philosophy (1808-1810). These lar to Paracelsus’ old idea that one poi- when I have only a few minutes to drawings show atomic symbols, the son could act as a purge for illness spend on learning a single facet of combination of atoms in simple, whole caused by another poison. chemical history, or when I have more numbers to form compounds, and a Generally, the book is well done time to delve into an entire era in description of why ice is less dense and there are numerous instances chemical history. I will also use it as a where Greenberg injects humor and reference in finding information about than water based on their molecular th structures. Further, Greenberg illus- levity into the writing. These tend to pre-20 century chemical history, espe- make the reading more enjoyable, and cially with regard to the images impor- trates Boyle’s Law using two plates from New Experiments Physico- even sometimes raise serious issues. tant to that history. Mechanical, Touching the Spring of the Air published in 1662 that show the apparatus Boyle used. The images are less commonly known, and so serve a useful purpose in providing a visual portal into chemical history. In addi- tion, the images, along with their accompanying descriptive text, provide an opportunity for the non-scientist to Eastern Scientific delve into our history. Anyone interested in the history of chemistry will want to have this book 1/2 page Ad Appears here on their reference shelf, especially because of its extensive use of visual Ad # EAST 584N images. The book is not, nor does it claim to be, a complete history of the science. Rather, it treats certain areas Strip Repro supplied in chemical history in a loose chrono- logical fashion. The topical units cover 1-3 pages on average, which allows short, flexible reading sessions. The treatment is often fragmented, switch- ing topics quickly. These features make the text less useful for a formal history of chemistry course, but more useful for intermittent reading or as a supplemental text. The book’s value

The Nucleus Summer 2001 19 From the Esselen Meeting

Rose Simon and Gus Esselen, III Catherine Hanson, Joanna Stengel, Joan (photos by Chu Jung) Foot

At the table (l. to r.) Mrs. DeSimone, Dr. and Mrs. Ed Samulski, Dr. Joseph DeSimone, Dr. Iclal Hartman (Esselen Comm. Chair) Dr. Timothy B. Frigo, Jack Esselen, Kathy Esselen, Bert Welling, Gus Esselen, III and Joseph DeSimone - NESACS Chair (photo by Jet Photographers) Mrs. E. Esselen, Joanna Stengel Award Presentation

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20 The Nucleus Summer 2001 BUSINESS DIRECTORY

SERVICES PRODUCTS Teachers’ Summer Institute The Chemistry of Polymers and Polymer Science August 6-9, 2001 University of Massachusetts, Amherst, MA Presentations by faculty members of the University of Massachusetts- Amherst, industrial chemists, teachers on topics of how to incorporate teach- ing about polymers into the curricu- lum, projects in polymers and plastics. Workshops, visit to the National Plas- tics Museum in Leominster. Additional Meetings: Saturday, October 6, 2001 at UMass- Amherst Saturday, November 3, 2001 at Burlington High School Saturday, December 1, 2001 at UMass- Amherst For detailed information, contact: Dr. Peter Nassif, Conference Coordinator [email protected]

May Puzzle Solution

The Nucleus Summer 2001 21 BUSINESS DIRECTORY

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The Nucleus Summer 2001 23 avr,M 01451 Harvard, MA 19 Mill Road Council Meeting Reports San Diego, April 4, 2001 tioons and Elections, attended its meet- ings and has been asked to chair its The Section was represented by its full Subcommittee on Election Procedures. complement of 12 Councilors/Alter- M.Hearn attended a meeting of nate Councilors at the meeting. Subcommittee Chairs of the Commit- Action items at the Meeting: tee on Chemistry and Public Affairs. (Unless stated otherwise, all NESACS M. Hoffman is the Program Chair representatives voted in favor of the for the Division of Chemical Educa- respective motions) tion and is a consultant on the Society Sunset Review of the Committee on Committee of Education Task Force on Environmental Improvement and the Undergraduate Programming at Committee on International Activities. National Meetings. On recommendation of the Committee D.Lewis attended the National on Committees, both committees were Chemistry Week Workshop and continued by unanimous votes. attended the Local Section Affairs Open Meeting.

AMERICAN CHEMICAL Bylaw Amendment to Increase the U.S. POSTAGE PAID OPOI ORG. NONPROFIT NORTHEASTERN Size of Standing Committees (from A.Light is a member of Commit- SOCIETY SECTION the current 15 to 25). An amendment tee on Economic and Professional to the motion to limit the maximum Affairs and its Subcommittee on size to 20 won approval (all your rep- Employment Services. She also resentative, except M.Singer voted in worked at the National Employment favor of the amendment). The main Clearing House Information/Library. motion was overwhelmingly approved. T. Light worked at NECH This amendment will take affect on throughout the meeting. approval by the ACS Board of Direc- D.Rickter has been put on the tors. President’s Task Force on K-12 Educa- tion. Calendar 2002 Dues The Budget and Finance Committee moved that the dues for For additional information, call: 2002 be the calculated amount accord- Boston Glycobiology - (781) 642-0025 ing to the bylaw provisions, to be Historical Check NESACS Homepage for late additions: $112. Eleven of the NESACS Repre- http://www.NESACS.org sentatives voted in favor, M. Singer Note also the MIT Chemistry Department voted against the increase. The Council Notes Webpage calendar: approved the dues of $112. Louis W. Mead, 80, died on Decem- http://web.mit.edu/chemistry/www/temp/seminas ber 7, 2000 at his home in Lexington, /pchemseminars.html CEPA ACS Academic Professional Guidelines. The 3rd edition of the Mass. after a long illness. He was a and the Harvard Chemistry web site for updates: guidelines presented by the Committee native of St. Louis and a chemical http://www- engineering graduate of Cornell Uni- chem.harvard.edu/events/Physical_Seminars.html on Economic and Professional Affairs (which includes the Harvard/MIT joint seminars). were approved. versity. As a member of the 4th Engi- neers Special Brigade during World The Committee on Local Section War II he participated in amphibious Affairs moved a change in the territory June 20 landings in the Pacific theater. After of the Savannah River Section and Dr. Obadiah Plante (MIT) the war he was employed in research at chartering a new Local Section: Mid- “Automated Synthesis of Oligosaccharides” Oak Ridge, Tenn. and at M.I.T.. Boston Glycobiology Discussion Group dle Georgia, both with the approval of He founded several small firms MIT Faculty Club, 6 pm the adjacent Local Sections concerned. Call (781) 642-0025 for dinner reservations. that developed radiopharmaceutical Both motions passed overwhelmingly. diagnostic tests, some of which are M. Chen reported that the Admis- currently used by hospitals. He was the sions Committee, of which she is a founder of the Mount Agamenticus ski member, discussed admission of those Notices for the Nucleus area in southern Maine. Calendar should be sent to: with a two-year degrees in Chemical Dr. Donald O. Rickter, Science and Chemical Technology, if James H. Parliman died on June 88 Hemlock St., followed by 5 years employment in the 15,1999 after a short illness. He was a Arlington, MA 02474-2157 field. 1943 graduate of the Worcester Poly- e-mail: [email protected] C. Costello attended as a member technic Institute and was a longtime the meeting of the Committee on Inter- member of ACS. He lived in Keene, national Activities. She also presented N.H. and was survived by his wife. We an invited paper at the Analytical Divi- regret that we have been unable to sion Award Symposium. acquire additional material on his Thomas R. Gilbert, an elected career from his estate. member of the Committee on Nomina- to be continued