Teaching Hospitals NHS Foundation Trust

THUR 4th Research JULY 2019 Industry Facing Day Event Programme

City of Research of Research City of Research Research Industry Facing Day 2019 | Contents Research Industry Facing Day 2019 | Introduction

CONTENTS INTRODUCTION

Introduction...... 3 Dear Invitee, part in, a unique achievement which is thanks in large part Welcome to Bradford! We Are Bradford...... 4 to the hard work of our excellent research nurses and I am delighted that you are investigators and not least the attending today’s Industry Welcome From The Director...... 6 Research, Management and Facing Day, organised by the Support Office. Meet The CEO...... 7 talented team in the Bradford Institute for Health Research, In short, we have enjoyed a Our Clinical Research Facility...... 8 and hope you enjoy hearing very successful partnership about the inspirational work of with industry over the years, Meet Our Research Teams...... 10 our speakers. a fact which was underlined again recently when we You may already be aware of became the first Trust in Programme...... 14 Bradford Teaching Hospitals Yorkshire to be named a NHS Foundation Trust’s rich preferred research site with Our Speakers...... 15 reputation for successful The Trust has global pharmaceutical giant delivery into the national had several Novartis. Our Achievements...... 22 commercial research portfolio, Global 1st, but did you know that our Today, we have a rich array European 1st The Research Management and Support Office...... 24 commercial research activity of speakers from both has grown by 10-15 percent industry and our talented and UK 1st Our Service Support Teams...... 26 every year since 2014? research teams who have Recruits into extensive experience in We currently deliver large commercial Notes...... 28 commercial research. numbers of patients into the Together, they have put studies in the national commercial portfolio together a programme last few years from several clinical areas, and which I hope you find have recruited several global, fruitful. European and UK-first recruits into commercial studies within Enjoy the day! Commercial recent years. research activity With best wishes, has grown by In the year 2018-19, we successfully recruited into 62 10-15 percent commercial studies across 14 every year since different specialities. In fact, 2014 Bradford Teaching Hospitals NHS Foundation Trust was the Dr Dinesh Saralaya only acute trust in Yorkshire with a large commercial Associate Director for Research, BIHR portfolio which achieved Strategic Clinical Lead for Pharma, over 80 per cent recruitment Yorkshire and Humber CRN across all the studies it took National Clinical Lead for Industry, Respiratory Medicine, NIHR

2 3 Research Industry Facing Day 2019 | We Are Bradford Research Industry Facing Day 2019 | We Are Bradford

The Trust is also, of course, deliver national objectives, • Raised awareness and WE ARE BRADFORD home to the Bradford Institute but more importantly to shared best practice to equip for Health Research (BIHR), enhance patient care. the research teams with where researchers have led the the knowledge and tools to Bradford Teaching Hospitals NHS Foundation Trust is a special place to development, validation and To this end, we are committed deliver commercial research work. While we’re a large regional centre recognised for clinical and implementation of the award- to forging even closer ties with successfully. the pharmaceutical industry. research excellence, we’re also known for our friendly and inclusive culture. winning Bradford Electronic Later this summer the region’s Frailty Index (eFI), among To achieve this, we have: research capacity will expand We employ just under 6,000 Today, Bradford Teaching remain at the heart of our many other world firsts. further, when the Wolfson staff, and another 1,000 Hospitals NHS Foundation work, giving all staff the space • A dedicated executive team Since it was founded in Centre for Applied Health people are part of our flexible Trust is responsible for to grow and the expertise which oversees commercial 2007, BIHR has developed Research (CAHR) officially workforce. We are proud of providing hospital services and facilities to take their development across the Trust and increased its expertise in opens next door to BIHR. It them all and our culture of for communities across careers to the next level. clinical research and notably • Expanded the Trust’s aims to improve the health dedication and innovation. Yorkshire and the North applied health research, Pharmacy in order to increase and wellbeing of children of . Although we Our staff work over several and now has a reputation its capacity for the storage and the elderly, and will bring We’ve been a vital part of serve a core population of sites, including Bradford for being one of the UK’s of trial medicines and together researchers from the community since 1825, around 500,000 people, we Royal Infirmary - where BIHR leading health research hubs. opened its doors to yet more the Universities of Bradford when Bradford Dispensary provide specialist services is based - which provides and Leeds with clinicians was founded to bring ‘medical the majority of inpatient industry-sponsored studies to a further 1.1 million. Building on its already from across the Trust. relief’ to deprived and destitute services, and St Luke’s • A Clinical Research Facility excellent reputation for families, and have continued As a teaching hospital, we’re Hospital, which predominantly which has dedicated developing innovative The CAHR has been made to care since then. We became at the forefront of research provides outpatient and space to deliver clinical medicines in association with possible thanks to a £1m a foundation trust on April and development in healthcare, rehabilitation services. We trials located on the main pharmaceutical companies, award from national charity 1, 2004 – one of the very and have received awards as also manage local community Bradford Royal Infirmary site Bradford Teaching Hospitals the Wolfson Foundation, first in the NHS to do so, a national and international hospitals at our Westwood NHS Foundation Trust aims • A research nurse manager which provides grants and our local community leader in many clinical fields. Park, Westbourne Green, to increase its commercial to support the nursing to support and promote still plays a pivotal role in Education, research and Shipley and Eccleshill sites. research activity year on infrastructure in recruitment excellence in fields including how we are governed. professional development year in order to amplify its and delivery science, medicine, and health. research reputation and

Considerable investment into research infrastructure has taken place on the Trust’s Bradford Royal Infirmary site over the last 12 years to create a suite of buildings that now make up the Trust’s health research hub and provides a focus for our research expertise. £9 million investment in research fac ility infrastructure

2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019

Bradford Institute for Clinical Research Facility opens £2 million extension to £1 million extension to the Through collaboration with the Universities Health Research (BIHR) after £1million renovation providing the BIHR to accommodate Clinical Research Facility to of Leeds and Bradford and the Trust, the was created through dedicated, high quality outpatient additional researchers provide accommodation creation of the Wolfson Centre for Applied £2million renovation of facilities for our researchers to due to grant success and to some of the clinical Health Research, a £3million building Temple Bank House conduct clinical research. increased research activity research teams. (funded in part via the Wolfson Foundation).

4 5 Research Industry Facing Day 2019 | Welcome From The Director Research Industry Facing Day 2019 | Meet The CEO

WELCOME FROM THE DIRECTOR

Bradford is a special place. The 5th largest city in the UK with the youngest population in Europe.

Our beautiful old mills are centres of patient safety a constant reminder of our research with our NIHR Patient impressive industrial heritage Safety Translational Centre, sector and local authority and our sea of Yorkshire and the top centre for applied with our Connected Bradford moors that surrounds us research in ageing with programme, and shown the bathes us in nature. Bradford our Centre for Ageing and power of linked data for has a strong traditional of rehabilitation. We have over research and innovation with ground-breaking innovation 50,000 Bradfordians actively our electronic frailty index and – introducing the universal involved in our research autism projects. We have our education, free school meals, studies and over the next five ground-breaking new Wolfson medical check-ups for children. years our goal is to increase Centre for Applied Health Over the last 15 years we have this to 100,000. Central to Research ready to open. rekindling on this historical our strategy is the importance track record to build our City of genuine community and Professor John Wright of Research in Bradford. We patient co-production in Director, Bradford Institute have established one of the research. for Health Research MEET THE CEO leading centres of child health research in the UK with Born We have established in Bradford, one of the leading comprehensive routine data Department of Health and to 1996, John was Private linkages across the health then NHS England. He shaped Secretary to the Secretary of strategy at national level, and State for Health. He studied was responsible for leading at the Universities of York and NHS England’s policy on a California and has an MBA range of issues, including from Manchester Business the Academic Health Science School. Networks and the review to John Holden is currently decide the national provision As Director of Strategy and Acting Chief Executive of Congenital Heart Services. Integration, John led on Officer. John was appointed developing and integrating to the position of Director of In previous roles, John was services, which deliver new Central to our Strategy and Integration for responsible for NHS quality models of care in the Bradford strategy is the Bradford Teaching Hospitals regulation, Foundation district and across the wider importance of NHS Foundation Trust in Trust policy, major capital region, August 2016, and as Deputy investment programmes, ensuring the Foundation Trust genuine community Chief Executive in April 2017. and project management of continues to provide high and patient co- the comprehensive spending quality care, which meets the production in John spent most of his review to secure NHS funds needs of the local population. career in senior roles at the from the Treasury. From 1995 research

6 7 Research Industry Facing Day 2019 | Our Clinical Research Facility Research Industry Facing Day 2019 | Our Clinical Research Facility

Store Room OUR CLINICAL Scan to take a tour of We have a secure record storage room where RESEARCH FACILITY our Clinical site files and patient Research information are stored. Facility The door has a digilock Opened in 2008, the facility has been designed and controlled access. with patients in mind. Our aim is to provide a high quality, clean, friendly and comfortable environment.

Lab

We have a small dedicated lab that houses -20, -70 and -80 freezers, several centrifuges including a cytocentrifuge and a refrigerated one. As with all areas Reception of the clinical research facility the equipment is correctly maintained. Daily temperature checks and service records A dedicated reception and waiting area providing a friendly and are available to support this. welcoming environment to research patients and visitors and a full reception service. In the spacious waiting room there are refreshment facilities as well as a children’s play area and TV.

Clinic Rooms

There are seven well equipped clinic rooms, all of which can be adapted to meet the requirements of individual research teams and their patients. Hot Desking Office Our rooms are versatile and we can increase/decrease the room size as necessary. All medical equipment is Our hot desking office is a space that sponsors serviced regularly with service records readily available. can use for monitoring visits. It is a comfortable space with plenty of room and Wifi is available. There are also lockers for personal belongings.

8 9 Research Industry Facing Day 2019 | Meet Our Research Teams Research Industry Facing Day 2019 | Meet Our Research Teams

MEET OUR RESEARCH TEAMS Infectious Diseases and Wound Care Infection research was involved in commercial research research in sexual health at established in 2012, and with MERK, Sanofi, Namsa and Locala. The team recently took Cardiology it covers a wide range of Biovotec. We are an adaptable over the management of the diseases. Since its inception, team who are collaborating vascular/wound care studies, Heart disease is one of the We are an acute secondary arrhythmias, hypertension, the team have developed with ICU on a sepsis study and and are planning to continue to most common serious illnesses care cardiology service dyslipidaemia, and acute a large and varied research with a non NHS organisation expand the number of trials for suffered by men and women providing in-patient and out- in-patient care for the same portfolio. We have been with the aim to re-establish this speciality. in the UK. The Coronary Care patient care to a population of range of conditions. Research unit was established in 1994 390,000. We deliver general into heart disease is an together with our research unit adult cardiology and manage important part of the work Oncology to improve patient treatment patients with stable ischaemic performed on the Coronary We run both national and radiotherapy and surgery. The Assistant, Jannika Lazarte; a and management of heart heart disease, valvular care unit here at Bradford. international trials in Colorectal, team consists of three Research Clinical Trials Officer, Kelvin disease within Bradford. heart disease, heart failure, Upper GI, Lung, Gynaecology, Nurses, Hayley Inman, Helen Stewart; and a Research Prostate and Breast Cancer Robertshaw, Kay Cockroft; an Administration Assistant, Haematology which involve chemotherapy, Epidemiology Clinical Trials Jane Sewell.

The Haematology Research lymphomas and myeloma The trials team consists of team run phase II, III and IV (excluding transplant and 2 full time, and 1 part time Stroke trials, ranging from complex radiotherapy). We have also research nurses as well Stroke Research has 2 nurses acute admission (ED), HASU, and to give us the opportunity chemotherapy trial to service run non-interventional studies as 3 staff shared with the and access to the generic ASU, REHAB and Community. to be involved with commercial evaluations. We cover all areas in non-malignant haematology Oncology Research team; an team. We work on NIHR 50% of all stroke admissions studies. We are collaborating of malignant haematology: such as Haemophilia and VTE, Epidemiology Trials Assistant, Portfolio Stroke trials. To are eligible for current trials. with Neurology with a plan to acute and chronic leukaemia’s, which are areas we hope to A Clinical Trials Officer and an maximise our patient pool we We recruit 70% of this patient launch Neurology commercial high and low grade expand. Administrative Assistant. recruit along the entire Stroke group. We are developing our trials. patient pathway from Hyper service to increase recruitment Neo-Natal

Bradford Children’s Research generations. Together we We have undertaken Ophthalmology gives babies, children, young hope to make researching commercial research with Bradford Ophthalmology nurses, a research associate 500 participants to these trials. people and their families the the effectiveness of new and TEVA, GSK and Bluebird bio research network (BORN) are practitioner, a research fellow, We have a diverse portfolio opportunity to be involved existing treatments part of all reaching target. We have one of the most experienced 2 research optometrists, and of studies, (phase II- IV) both in research that will improve routine care. also worked with Nutrinia clinical research teams 5 accredited ophthalmic industry sponsored and NIHR/ treatments and care for future recruiting to a neonatal study engaged in vision and eye photographers. BORN have academic portfolio studies. but the study was closed research within the UK. The facilitated over 30 clinical trials early. We have 4 experienced team now has 2 research since 2008 and recruited over Research Nurses, 1 Clinical Trials Administrator and 1 Research Admin Apprentice. Dermatology

We have an increasing that dermatology research is improvement in treatment as portfolio of clinical trials at an area which has previously well as the clinical care leading Bradford Teaching Hospitals been under represented in the to better quality of life for our Dermatology Research UK. Our continued research patients. Department based at St Luke’s into the various forms of Hospital. We are conscious skin condition contributes to

10 11 Research Industry Facing Day 2019 | Meet Our Research Teams Research Industry Facing Day 2019 | Meet Our Research Teams

Rheumatology Reproductive Health and Childbirth

Rheumatology research in seven. We carry out a mixture impact factor publications Our Reproductive Health Farrar (NIHR Post Doc Research gynaecology research nurse Bradford was established in of portfolio non-commercial including the Lancet and and Childbirth team is led fellow and Lead research and a research administrative 1996 as a small two person studies and commercial studies have developed a number of by Professor Derek Tuffnell midwife). The team consists assistant. We co-ordinate team. Over the years modest of new pharmaceuticals. instruments for use in clinical (Consultant Obstetrician and of a senior research midwife, studies in Maternity and expansion had taken place and However, although relatively rheumatology research in the Gynaecologist) and Diane three research midwives, a Gynaecology care. our staff list now comprises small, we have a list of high field of psoriatic arthritis.

Anaesthetics and Critical Care Clinical research teams Contact details

At present our team consists of: Team expansion is ongoing Commercial Trial and seeking Respiratory Medicine Diabetes with a post out to advert more in the future. We have Karen Regan, Respiratory Lead Research Nurse Joanne Thorpe, Diabetes & Endocrinology • ICU Research Lead Clinician for a Research Nurse a research engaged and [email protected] Lead Research Nurse and PI, Dr Tom Lawton or Research ODP. active medical and nursing Telephone: 01274383383 [email protected] • Future Co PI, staff who have experience Dr Whitelaw Dr James Morgan We have active support from of recruiting and supporting Cardiology [email protected] the local Generic Support trial procedures out of hours. Craig Atkinson, Cardiology Research Nurse Telephone: 01274 383361 • Anaesthesia PI, Research Team led by Karen Bradford has a 16 bedded [email protected] Dr Andrew Brennan Regan. We are an active general Critical Care Unit Reproductive Health and Childbirth • Research Sister, research team with a portfolio (4 HDU and 12 ICU beds) Dermatology Jenny Syson, Lead Research Midwife Louise Akeroyd of recruiting NIHR studies and There are 20 theatres with Jennifer Ott, Dermatology Research Nurse [email protected] are engaging with Commercial a throughput of about 100 [email protected] Telephone: 01274 364506. Sponsors to open our first patients a day. Ophthalmology Neo-Natal Nicola Hawes, Ophthalmology Dr Sam Oddie (Lead) Respiratory Lead Research Nurse [email protected] [email protected] Rachel Wane, Paediatric Research Nurse Our team predominantly and 1 research [email protected] Infectious Diseases and Wound Care specialises in Asthma and administrator. We Telephone: 01274 382466 COPD but we also have have vast experience The Respiratory Jackie Todd, Infectious Diseases experience in bronchiectasis in performing Clinical Trials Unit Lead Research Nurse Haematology and nasal polyps. Our commercial trials. [email protected] Victoria Drew, Haematology team consists of 3 research has grown to Lead Research Nurse Gastroenterology nurses, 1 research assistant become one of [email protected] Sophie Stephenson, GI Lead Research Nurse the largest self- [email protected] Stroke funded respiratory Ruth Bellfield, Stroke Lead Research Nurse Hepatology [email protected] clinical trials Janet Johnson, Hepatology Research Sister centres in the UK [email protected] Oncology Hayley Inman, Oncology Lead Research Nurse Rheumatology [email protected] Janet Curran, Rheumatology Research Nurse [email protected] Anaesthetics and Critical Care Louise Akeroyd,Anaesthesia & Critical Care Renal Research Sister Jodi Paget, Renal Research Sister [email protected] [email protected]

12 13 Research Industry Facing Day 2019 | Programme Research Industry Facing Day 2019 | Our Speakers

PROGRAMME OUR SPEAKERS

In the Sovereign Lecture Theatre, Dr Dinesh Saralaya MD FRCP Bradford Royal Infirmary Consultant Respiratory Physician and Associate Director for Research, Bradford Teaching Hospitals NHS Foundation Trust 09.00 am Refreshments 09.30 am Introduction Dinesh also heads up the Dr Dinesh Saralaya, Consultant in Respiratory Medicine and Associate Director for Research Respiratory Clinical Trials Unit 09.40 am Welcome at the BIHR, which has grown John Holden, Acting Chief Executive to become one of the largest Professor John Wright, Director of BIHR/Research self-funded respiratory clinical 09.50 am Sanofi trials centres in the UK. It has Raj Rout, European Medical Director, Sanofi Aventis recruited several global and 10.00 am The Renal Research Team European-first patients into its Dr Tarun Bansal, Consultant Nephrologist, clinical trials programme from Jodi Paget, Renal Research Sister across the Yorkshire region, 10.10 am AstraZeneca and has established links Rodney Hughes, Medical Affairs, Astra Zeneca UK Dinesh is currently Consultant with major pharmaceutical 10.20 am The Diabetes Research Team Respiratory Physician and companies and clinical trials Dr Donald Whitelaw, Consultant in Diabetes & Endocrinology Honorary Senior Lecturer at organisations. Jo Thorpe, Lead Diabetes & Endocrinology Research Nurse, Diabetes & Endocrinology Dept the Trust and, since 2014, 10.30 am Refreshment break Associate Director for Research Dinesh has been the chief co- 11.10 am IQVIA ordinating investigator in the James Brook, Head of UK & Ireland Clinical Site Management at the Bradford Institute for UK for several multi-national 11.20 am The Gastroenterology/Hepatology Research Team Health Research (BIHR). phase two and three severe Sophie Stephenson, Lead GI Research Nurse, Since his appointment he asthma and COPD trials, and Sarah Tinker, Hepatology Research Nurse has grown the commercial has a particular interest in 11.30 am GSK Bob Kilbey, Senior Clinical Research Associate research portfolio at the BIHR inhalation profiles in patients Claire Lill, Senior Clinical Research Associate to more than £1.25 million with severe asthma and COPD 11.40 am Patient Research Ambassador annually. and many published articles in Ruby Bhatti the field. 11.50 am NIHR CRN Yorkshire & Humber He also leads the Trust’s Tanya Turgoose, Industry Manager severe asthma service, and is In 2015 and 2016, he was Professor Paul Dimitri, Strategic Lead for Medical Technology the National Clinical Lead for named the best Principal 12.10 pm Lunch & Networking Industry for the Respiratory Investigator Award in the UK 01.30 pm Afternoon Breakout Sessions Disorders Speciality Group, and for his delivery into NIHR’s This part of the programme is for research teams who have pre-booked a meeting with an industry NIHR and Clinical Divisional commercial respiratory sponsor to discuss upcoming trials or business opportunities in general. Lead for Industry at the research portfolio. Breakout 1 GSK: Room Field House, BRI Breakout 3 AstraZeneca: Room Field House, BRI Yorkshire and Humber Clinical Breakout 2 SANOFI: Room Field House, BRI Breakout 4 IQVIA: Room Field House, BRI Research Network. 03.30 pm Reconvene in the Sovereign Lecture Theatre & Close Please note that the programme is subject to change on the day.

14 15 Research Industry Facing Day 2019 | Our Speakers Research Industry Facing Day 2019 | Our Speakers

Rodney Hughes Medical Affairs, Astra Zeneca UK Physician who has worked and is based in Cambridge as as a COPD Specialist with an the Global Lead for External interest in Clinical Research Scientific Engagement and for 15 years in Cambridge is the Global Study Physician and and Sheffield. He has for the NOVELTY Study. His experience in undertaking primary interest is facilitating NIHR and Pharmaceutical collaborations with clinicians funded Clinical Trials and undertaking research to As a teaching Real World Clinical Database/ develop meaningful treatment “Dr Rod Hughes is a New Epidemiological studies. approaches for patients with hospital, Zealand trained Respiratory chronic lung disease. Bradford is at He joined AstraZeneca in 2017 the forefront of research and James Brook development Head of UK and Ireland Clinical Site Management and GSK. EMEA, the Prime and Partner network in Western Europe, Such diverse companies and and Feasibility and Site ID, roles are reflected in James’ Western Europe. extensive therapeutic and research knowledge and His guiding principle is that it is understanding. a patient’s right to participate Professor John Wright in the latest research studies as James’ current role, Head of James joined IQVIA in 2008 part of their routine care. Director, Bradford Institute for Health Research UK and Ireland Clinical, allows following a career which him to apply his learning from James now brings this in-depth John Wright is a doctor In 2007 he set up the Born covers over 25 years in the a diverse background at IQVIA, patient, site, therapeutic, and and epidemiologist with in Bradford (BiB) cohort study pharmaceutical industry from having carried out senior roles clinical research experience to a background in hospital which is following the lives CRA and progressing through heading Therapeutic Strategy Bradford. medicine and public health of over 13,000 families as positions in Wyeth, Novartis, in the UK and Africa. their children grow up.

He established and leads Evidence from BiB studies Raj Rout the Bradford Institute for has informed international European Medical Director, Sanofi Aventis Health Research and Wolfson policy about the harm of air He has worked to develop Oxford University, where stage drug development Centre for Applied Health pollution and the protective sustainable public health he investigated the cellular and launching of drugs in Research, working to speed effect of green space. In 2016 programmes in Africa for and molecular basis of RA, atopic dermatitis and up translation of medical he set up Born in Bradford’s over 25 years, and in 2015 osteoarthritis asthma. He is a Member of research into practice and Better Start cohort to test was awarded the West policy. He is Clinical Director of new approaches to providing the Faculty of pharmaceutical Africa medal by the Prime As a clinician he holds the the Yorkshire and Humberside the best support in the medicine, and holds the Minister for his work in FRCS (Orth) from the Royal Improvement Academy which crucial period of early life. diploma in pharmaceutical the Ebola epidemic. College of Surgeons and was supports innovation and medicine. Current interests previously an investigator in improvement in the NHS. Raj joined Sanofi Genyzme in include the generation of real 2014. He studied medicine in a number of clinical trials. world evidence and the use of Cambridge and has a D.Phil Since joining industry he digital technologies to improve in orthopaedic surgery from has been involved in late patient outcomes.

16 17 Research Industry Facing Day 2019 | Our Speakers Research Industry Facing Day 2019 | Our Speakers

Bob Kilbey Tanya Turgoose Senior Clinical Research Associate, GSK Industry Manager | CRN Yorkshire and the Humber | NIHR Clinical Research Network (CRN) Liverpool University 30 Anyone who knows me, or has years ago, researching the ever asked me why I love my commercial clinical research Previous roles within the NHS respiratory physiology of fish, job will know that I always cite across the Y&H region. She is have included being responsible I got to know someone who the same two reasons, ‘I’ve accountable for the planning, for Research Governance worked in clinical research and never had two days the same performance and delivery. oversight of commercial trials the rest, as they say, is history! and being part of the process at Sheffield Teaching Hospitals of getting better treatments to Tanya has a background within NHS Foundation Trust and I started out with a couple of patients.’ industry working in clinical being part of the Senior Service Always destined to ‘be a years in sales before moving Tanya is the Industry Operation trial delivery at Richmond Delivery and Sustainability Team scientist’, my degree in Marine into clinical research – and Together, they represent more Manager for the NIHR Clinical Pharmacology, Parexel and at Pennine Care NHS Trust - Zoology often surprises people. in the ensuing 28 years I’ve than enough to keep me Research Network Yorkshire Covance before joining the specifically responsible for the But what can I say – I just love worked across all four phases, smiling and determined to do and Humber (CRN Y&H) and NHS. Trust’s Research, Innovation and the water and what’s in it! in therapy areas as diverse all I can to make each new is responsible for driving Knowledge Departments. as paediatric IBS and HIV, or project a success. During a two-year post- seasonal flu and septic shock. graduate research role at Professor Paul Dimitri BSc, MBChB,FRCPCH, PhD National Children’s Specialty Lead, NIHR Claire Lill Clinical Research Network Senior Clinical Research Associate, GSK Health Network (TITCH - and young people receiving www.titch.org.uk). healthcare in the UK. I chose a role as a data to help people do more, feel manager at a contact research better and live longer. NIHR CYP MedTech and Paul works at Sheffield organisation (CRO), which TITCH were established to Children’s NHS Foundation This job is definitely not boring opened the door to the endless support the development Trust as a Professor of and brings the opportunity to possibilities of clinical research! and adoption of technology Child Health, Consultant see places you’d never pick that will improve the delivery in Paediatric Endocrinology Some 10 years on I’ve worked on a map. There’s never a dull Professor Paul Dimitri is of healthcare for children and Director of Research & across all four phases of moment, whether that involves the NIHR Clinical Research Network National Children’s and young people. Paul and Innovation. Paul also holds Having realised I was a clumsy clinical research as a Clinical trying to get an investigator Specialty Lead, the Director of his team work with industry additional positions including individual my degree in Research Associate, in an to do something they don’t the NIHR Children & Young partners, academics, designers, the NIHR Yorkshire and Biomedical Sciences seemed array of therapy areas. The want to do or giving your site People MedTech Cooperative engineers, patients and their Humber Clinical Research a bad idea. Three years of role gives great opportunities a high-five for recruiting their (www.cypmedtech.nihr.ac.uk) families to develop the most Network Strategic Lead for knocking over lab samples and to travel, meet interesting first patient for a study – it’s all and the Clinical Director advanced health technology Medical Technology and was I thought I wasn’t going to be people and play a key role in in a day’s work as a CRA. for the National Technology ensuring the best health and previously the Deputy Director a scientist. So, looking into my the development of medicines Innovation Transforming Child opportunities for children for the Medicines for Children’s placement year at university Research Network (East).

18 19 Research Industry Facing Day 2019 | Our Speakers Research Industry Facing Day 2019 | Our Speakers

Ruby Bhatti OBE Diabetes Research Team

She sits as an associate hospital Ruby is also co-chair of the Diabetes Research was related studies and manager for the Mental Health Service User Research Group established by Dr Donald commercial therapy Department at Bradford District which supports various Whitelaw in 2004. As a related studies. Care NHS Foundation Trust, research bids at the university, team we are committed a role which enables patients and provides the faculty with to developing a diverse Currently, the to have their cases considered a wealth of expertise and portfolio in both diabetes and Diabetes & independently, and is also a knowledge gained through her diabetic foot ulcer studies. Endocrinology member of Bradford District broad portfolio of involvement. The team facilitates the Research Team Care NHS Foundation Trust’s diabetic research portfolio at incorporate three “I am a Consultant Solicitor, Mental Health Legislative She is also a Patient and Carer Bradford Teaching Hospital consultants whom all act as wife and mother. I was born Committee. Lecturer at the university and by participation in both NIHR PI’s, two research nurses and and bred in Bradford.” has been awarded Associate funded observational-outcome one clinical trials assistant She has supported the Fellow of the Higher Education She is chair of the Quality and since Academy (AFHEA) status. Safety Patients’ Panel, based 2007, and has been a member at Bradford Institute for Health of the Service User and Carers’ Ruby is also a fellow of Gastroenterology and Hepatology Research Team and Research (BIHR), panel Group Advisory Board at the the Royal Society for the member for The Improvement Faculty of Health Studies for Encouragement of Arts, and Dr Sulleman Moreea Academy, and public reviewer several years. Manufactures and Commerce for Hepatology. for the National Institute of (FRSA). Health Research (NIHR). Our aim is to demonstrate how engagement in clinical research leads to improvement Renal Research Team in health outcomes and the management of Research is an important part patients’ quality of life. of the work undertaken in the Both the Gastroenterology Bradford Renal Unit. Our focus and Hepatology teams is on clinical research, looking have substantial experience at treatment interventions that of recruiting patients into may improve the quality, safety commercial studies, which and experience of care we The Gastroenterology liver disease such as viral have predominantly been provide for our patients. We and Hepatology Research hepatitis, autoimmune liver phase II and III. The Hepatology have established a portfolio of Department, collectively diseases, alcohol and non- team, however, recently local, regional, national and known as Digestive Diseases, alcoholic liver conditions and recruited to the first phase international projects, and Dr Habib is based at Bradford Royal pancreatic and biliary disorders. I study in Bradford trialling are well supported through Akbani, Dr Russell Infirmary but we also work at a Hepatitis B vaccine. successful funding applications transplantation, Roberts, Dr Mansoor Ali, Dr St Luke’s Hospital. We have As a speciality, we work very closely with all medical teams, to the West Yorkshire Clinical and dialysis, although our Ahsan Syed, Dr Helen Ford a dedicated research team of We would welcome the specialist nurses, our wards Research Network (CLRN). research activity covers all of and associate specialist in renal clinicians, nurses, and our own opportunity to work with and other health professionals the Trust’s sites. medicine Dr Ramla Mumtaz. clinical trials administrator. more pharma companies The renal research team is to promote, recruit and across our specialty. based at St Luke’s hospital The research team has a All have an active interest The main areas we deal with deliver research studies. where we are involved in a broad membership and is led in research and have are inflammatory bowel variety of research studies by Sister Jodi Paget and our been involved in a variety disease, upper and lower Our Consultants are Dr Cathryn involving patients from three consultant Nephrologists Dr of commercial and non- gastrointestinal cancers and Preston for Gastroenterology, main areas: nephrology, Tarun Bansal, Dr John Stoves, commercial portfolio studies.

20 21 Research Industry Facing Day 2019 | Our Achievements Research Industry Facing Day 2019 | Our Achievements

651 Respiratory research were the second First OUR ACHIEVEMENTS Active Research highest recruiters to commercial European Studies in 18/19 trials in the UK between 2015 & patient for 2019, second only to The Brompton. the RHINE study Also were 3rd in the UK for the sponsored by ROCHE In one week highest number of commercial trials Pharmaceuticals in November performed during that time. 2017 we achieved a global first patient with GSK and a European first Dr Steven Lindsay patient with Astra and Dr Paul Sainsbury Zeneca were co-authors on a new international For the last study, published in the 2 years we UK first for New England, medical First UK have consistently Novartis in Journal of Medicine, site to open recruited In 2018 we 35% April 2019 which provides evidence for an effective and recruit to of all stroke were the highest treatment for patients with refractory FOCUS CTIMP admissions angina who previously would have not recruiting site in trial been suitable for conventional treatments. the world in a phase 1b study with Genetech. Bradford Trust achieved 80.9%

recruitment target for First UK 2018-2019. In terms site to complete We were the first First rest of of large acute trusts remote close hospital outside of this puts BTHFT first in world patient for down for FOCUS North America to Yorkshire & Humber. the TENAYA study CTIMP trial UK recruit a patient into sponsored by ROCHE the MERLIN TIMI 36 first for Pharmaceuticals (Ranolazine in ACS). Gossamer Recruited 7 in March 14,281 patients, 2 over 2019 Research agreed target, Participants for Bluebird Bio recruited in 17/18

22 23 Research Industry Facing Day 2019 | The Research Management and Support Office Research Industry Facing Day 2019 | The Research Management and Support Office

We are all very impressed with the efficiency of the R&D process. A real example of how it should be done. A Very warm welcome to CALIBRE

THE RESEARCH MANAGEMENT Contracts

AND SUPPORT OFFICE Our contracts team work hard with industry The key to our success is the close working partners to ensure contracts are finalised relationship we have with our principal Our Research Management • research feasibility • research performance ready for prompt sign-off and in doing so investigators, research nurses, pharmacy and and Support Office provides management have played a vital role in the achievement of finance colleagues; all of us working closely • contractual review and prestigious awards such as First Global Recruit with industry partners to secure contracts and advice and support on all oversight of research studies • development of research aspects of research including - and European First patients. reflect the needs of our patients. • financial management of infrastructure, capacity and • research governance research capability Our contact details are: • research information • Trust approval for research Early engagement and feasibility Pharmacy management and reporting Contact the research team directly Email: [email protected]

Meet Our Patient Research Ambassadors Contract and budget review Email: [email protected] Our Patient Research Ambassadors highlight the importance of research to high-quality healthcare. They play a vital role in ensuring that people using our services are aware of the treatment options and research studies open to them.

Ruby Bhatti OBE Ann Shone Rabia Kausar Mariam Nisa Tamas

24 25 Research Industry Facing Day 2019 | Our Service Support Teams Research Industry Facing Day 2019 | Our Service Support Teams

Pharmacy Support OUR SERVICE SUPPORT TEAMS Services The pharmacy clinical trials team consists of experienced members of staff – two Radiology/Pathology pharmacy technicians, and two pharmacists. We have all Our radiology dept at BTHFT They have helped the imaging worked in clinical trials for a has a very proud tradition aspect of several COPD studies number of years and believe of research. The department in the last 5 years we are a well-formed and has pioneered several studies efficient team. in Bowel cancer screening We have a newly refurbished and pioneered the use of CT Hospital Lab providing an All clinical trials paperwork actively recruiting patients, some for many years. We Virtual colonoscopy in the excellent service to our and medications are stored the majority of which are are able to be flexible and detection of bowel cancer research teams. in a dedicated clinical trials commercial studies. supportive of each team’s room with limited staff access. requirements, and offer input Room and fridge temperatures Having supported clinical and advice in terms of legal Medical Illustration are monitored 24 hours a day trials from many different requirements and solving via an electronic system. A sponsors, our team has a practical issues. We have been Our award-winning Medical Bradford Teaching Hospitals recent extension to the clinical wide experience of different involved in studies that have Illustration Department NHS Foundation Trust has trials room has increased interactive web response recruited global first patients, provides a comprehensive adopted the IMI Code of our capacity for the storage systems (IWRS). We are and are able to respond to range of photographic, graphic Responsible Practice and of investigational medicinal well practiced in using changing needs when speed and multimedia services to protocols for ethical conduct products (IMPs), giving us accountability logs and are becomes essential. healthcare professionals. and legal compliance in more than enough room for able to work with sponsor respect of patient consent trials involving IMPs which paperwork or design our own The department uses the latest and confidentiality. All clinical need to be stored at room if needed. equipment and techniques images are uploaded to the temperature or in a fridge. We have good working to provide services at the Trust’s secure clinical image We are currently supporting relationships with the research leading edge of photographic database which is accessed by over 50 trials which are teams, having worked with technology and has won clinicians. numerous awards.

Scan to take a tour of our Clinical Trials Pharmacy

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NOTES

Making research real

MID Ref:19040304

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