Supplemental Table S5 A Probe Symbol Description Fold Change raw p-value BH-value 1424032_at 0610039P13Rik RIKEN cDNA 0610039P13 0.55161976 0.001110473 0.035847968 1438176_x_at 1110031B06Rik RIKEN cDNA 1110031B06 gene 1.546320853 0.000575527 0.026980808 1455040_s_at 1110062M06Rik RIKEN cDNA 1110062M06 gene 0.53766793 0.000526255 0.025845734 1438511_a_at 1190002H23Rik RIKEN cDNA 1190002H23 gene 0.625269719 0.000480693 0.024788481 1456603_at 1500005K14Rik RIKEN cDNA 1500005K14 gene 0.672783447 0.000191911 0.0193647 1429907_at 1700094D03Rik RIKEN cDNA 1700094D03 gene 1.21499778 0.000577376 0.027011654 1418319_at 1810047C23Rik RIKEN cDNA 1810047C23 gene 0.814393041 0.000460153 0.024569357 1425333_at 1810048P08Rik RIKEN cDNA 1810048P08 gene 1.258622557 0.000635157 0.028093004 1439465_x_at 2310016E02Rik RIKEN cDNA 2310016E02 gene 1.465167974 0.00158772 0.040937929 1452365_at 4732435N03Rik RIKEN cDNA 4732435N03 gene 1.188684952 7.75E-05 0.01343138 1420721_at 4921536K21Rik RIKEN cDNA 4921536K21 gene 0.792184179 0.000702317 0.029455789 1454606_at 4933426M11Rik RIKEN cDNA 4933426M11 gene 1.440890915 0.000243944 0.020147563 1422906_at Abcg2 ATP-binding cassette, sub-family G (WHITE), member 1.519610931 0.000582547 0.027086027 1416863_at Abhd8 abhydrolase domain containing 8 1.335858135 0.001597529 0.041026484 1448213_at Anxa1 A1 0.618671358 0.00046908 0.024637532 1460330_at Anxa3 0.754566129 1.87E-05 0.007312522 1421223_a_at Anxa4 1.691634746 0.000942316 0.033257546 1424457_at Apbb3 amyloid beta (A4) precursor -binding, family B, m 1.285350473 0.000274466 0.020621301 1423714_at Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae 0.755897287 0.000188676 0.0193647 1435112_a_at Atp5h ATP synthase, H+ transporting, mitochondrial F0 comp 0.893930371 0.002370621 0.049943713 1439456_x_at Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 0.788529376 0.000671988 0.028874457 1415866_at AW538196 expressed sequence AW538196 1.41407995 0.001433524 0.039558885 1419216_at Azi1 5-azacytidine induced gene 1 1.436787766 2.45E-05 0.008650593 1424516_at B230354K17Rik RIKEN cDNA B230354K17 gene 1.644133266 2.78E-05 0.009007606 1427511_at B2m beta-2 microglobulin 1.821673191 5.52E-05 0.011854561 1451836_at BC022651 cDNA sequence BC022651 0.7189456 0.002095949 0.047029738 1435087_at BC039093 cDNA sequence BC039093 1.162684776 0.001865749 0.044272805 1417493_at Bmi1 B lymphoma Mo-MLV insertion region 1 1.464126734 0.000185258 0.0193647 1416924_at Bri3 brain protein I3 1.544927994 1.57E-05 0.006947722 1415692_s_at Canx 0.570928425 0.001566949 0.040836276 1424093_x_at Cd151 CD151 antigen 1.969029848 0.000427831 0.024208219 1416072_at Cd34 CD34 antigen 2.748385281 0.000185502 0.0193647 1435220_s_at Cdc42se2 CDC42 small effector 2 1.490715314 0.001418475 0.039399923 1460682_s_at Ceacam2 CEA-related molecule 2 0.717390438 0.001825051 0.043866955 1454641_at Cggbp1 CGG triplet repeat binding protein 1 1.23704051 4.37E-05 0.010452948 1460338_a_at Crlf3 cytokine receptor-like factor 3 1.893360719 0.001641848 0.041577611 1449129_a_at Csen , presenilin binding protein, EF hand transcript 0.694555516 2.83E-05 0.009007606 1448471_a_at Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha 14.59057271 0.000823149 0.031435038 1416811_s_at Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha 12.52573452 0.001097247 0.035668373 1451019_at Ctsf cathepsin F 1.420020257 0.000272363 0.020544695 1433908_a_at Cttn cortactin 3.545420566 0.000346366 0.022010729 1417039_a_at Cul7 cullin 7 2.428570811 0.000783045 0.030689178 1451426_at D11Lgp2e DNA segment, Chr 11, Lothar Hennighausen 2, express 1.540855922 0.001449052 0.039714556 1416708_a_at D7Bwg0611e DNA segment, Chr 7, Brigham & Women's Genetics 06 1.649383802 6.09E-05 0.01214869 1421936_at Dapp1 dual adaptor for phosphotyrosine and 3-phosphoinositid 1.688791945 0.000307889 0.021628489 1438093_x_at Dbi diazepam binding inhibitor 0.812441491 0.000571863 0.026946643 1453251_at Dhx30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 1.396776146 3.95E-05 0.010273107 1432066_at Dnaja3 DnaJ (Hsp40) homolog, subfamily A, member 3 0.775673094 0.000346752 0.022010729 1448892_at Dock7 dedicator of cytokinesis 7 1.953168002 0.000167317 0.018590066 1417540_at Elf1 E74-like factor 1 1.641853799 0.000964438 0.033511647 1418059_at Eltd1 EGF, latrophilin seven transmembrane domain containi 3.089304358 9.88E-07 0.003195994 1418058_at Eltd1 EGF, latrophilin seven transmembrane domain containi 1.976743655 0.001341902 0.038444124 1421699_at Enam enamelin 0.777099544 0.000214446 0.019463139 1432176_a_at Eng endoglin 3.043337922 0.001250496 0.037089871 1426010_a_at Epb4.1l3 erythrocyte protein band 4.1-like 3 1.433511604 0.001675235 0.041860363 1454169_a_at Epsti1 epithelial stromal interaction 1 (breast) 1.726629133 0.00107982 0.035612091 1450935_at Ercc5 excision repair cross-complementing rodent repair defic 1.200987769 0.00156758 0.040836276 1433514_at Etnk1 ethanolamine 1 1.241741274 0.000129338 0.016038504 1449023_a_at Ezh1 enhancer of zeste homolog 1 (Drosophila) 1.490365658 0.000396436 0.023168317 1437308_s_at F2r coagulation factor II (thrombin) receptor 4.359222809 0.000933971 0.033257546 1451263_a_at Fabp4 fatty acid binding protein 4, adipocyte 3.577193161 0.000297772 0.021234667 1417023_a_at Fabp4 fatty acid binding protein 4, adipocyte 4.026932533 0.000693637 0.029289558 1456615_a_at Falz fetal Alzheimer antigen 1.273713777 0.000204266 0.019394441 1452828_at Fbxo21 F-box only protein 21 1.443035251 0.000928404 0.033212087 1426750_at Flnb filamin, beta 0.62700177 0.002320182 0.049459781 1417544_a_at Flot2 flotillin 2 0.798688809 0.000593962 0.027336709 1426982_at Flywch1 FLYWCH-type zinc finger 1 1.240072961 0.002205207 0.048173129 1434831_a_at Foxo3a forkhead box O3a 1.323710341 0.000640584 0.028147188 1416418_at Gabarapl1 gamma-aminobutyric acid (GABA(A)) receptor-associat 1.937325453 0.000385043 0.022692514 1423391_at Git2 G protein-coupled receptor kinase-interactor 2 1.603162562 0.000598999 0.027381311 1426236_a_at Glul glutamate-ammonia ligase (glutamine synthase) 1.49257497 0.000219717 0.019623685 1427509_at Gm937 gene model 937, (NCBI) 0.653842735 0.001235094 0.03697134 1431777_a_at Hmgn3 high mobility group nucleosomal binding domain 3 2.09912002 0.000750263 0.029906908 1434875_a_at Hmgn3 high mobility group nucleosomal binding domain 3 2.08770845 0.002245373 0.048773132 1437234_x_at Hrmt1l1 heterogeneous nuclear ribonucleoprotein methyltransfe 2.998888853 0.001913835 0.044814164 1451567_a_at Ifi203 interferon activated gene 203 2.69880229 0.000209475 0.019403341 1448775_at Ifi203 interferon activated gene 203 2.840385069 0.000263963 0.020544695 1452231_x_at Ifi205 interferon activated gene 205 2.229101287 4.52E-05 0.010682119 1426906_at Ifi205 interferon activated gene 205 1.963936527 0.000383253 0.022692514 1426278_at Ifi27 interferon, alpha-inducible protein 27 1.961905894 0.000336059 0.022010729 1426276_at Ifih1 interferon induced with helicase C domain 1 1.446599099 6.52E-05 0.012336168 1436420_a_at Ipo4 importin 4 1.962136373 0.000783122 0.030689178 1418265_s_at Irf2 interferon regulatory factor 2 1.396881173 0.00013516 0.016647297 1421322_a_at Isgf3g interferon dependent positive acting transcription factor 1.564587343 4.05E-05 0.010273107 1449841_at Kif3a kinesin family member 3A 1.822950986 6.66E-06 0.005058848 1455434_a_at Ktn1 kinectin 1 1.488731636 0.002165271 0.047971001 1430447_a_at Lair1 leukocyte-associated Ig-like receptor 1 0.571315127 6.30E-05 0.012233107 1416148_at Laptm4b lysosomal-associated protein transmembrane 4B 1.234185345 0.000515862 0.025556575 1438932_at LOC381240 0.669312138 0.002375533 0.0499506 1421571_a_at Ly6c lymphocyte antigen 6 complex, locus C 0.706563041 1.50E-05 0.006856421 1434674_at Lyst lysosomal trafficking regulator 0.710491778 0.001144698 0.035954864 1423284_at Mansc1 MANSC domain containing 1 2.013237954 0.00147673 0.040102612 1426759_at Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 1.829204605 0.000270745 0.020544695 1427040_at Mdfic MyoD family inhibitor domain containing 1.321351611 0.00212479 0.047482467 1424852_at Mef2c myocyte enhancer factor 2C 2.148000054 2.16E-05 0.008053739 1451506_at Mef2c myocyte enhancer factor 2C 2.04930192 0.000607506 0.027404188 1450992_a_at Meis1 myeloid ecotropic viral integration site 1 2.861538387 0.00058067 0.027054197 1415897_a_at Mgst1 microsomal glutathione S-transferase 1 0.70632491 3.13E-05 0.009595536 1449188_at Midn midnolin 1.456788898 0.001276816 0.037510427 1423595_at Mina myc induced nuclear antigen 1.23113095 0.000120047 0.015654383 1439364_a_at Mmp2 matrix metallopeptidase 2 1.425531335 0.002097447 0.047029738 1455099_at Mogat2 monoacylglycerol O-acyltransferase 2 0.700957917 0.002088546 0.047022518 1415762_x_at Mrpl52 mitochondrial ribosomal protein L52 1.532231346 8.82E-05 0.014274707 1415761_at Mrpl52 mitochondrial ribosomal protein L52 1.582529657 0.000124731 0.015899693 1427938_at Mycbp c-myc binding protein 0.868832879 0.000487675 0.024936677 1426864_a_at Ncam1 neural 1 0.614068028 0.000198 0.0193647 1425609_at Ncf1 cytosolic factor 1 0.693384284 0.00074276 0.029891318 1452196_a_at Nckap1 NCK-associated protein 1 2.232540223 0.000947607 0.033283609 1451109_a_at Nedd4 neural precursor cell expressed, developmentally down 1.662670568 0.001659437 0.041765717 1419078_at Nin ninein 0.626381147 0.00143006 0.039522621 1455143_at Nlgn2 neuroligin 2 1.845548456 0.001607032 0.041151825 1424775_at Oas1g 2'-5' oligoadenylate synthetase 1G 1.603903306 0.000330033 0.022010729 1453196_a_at Oasl2 2'-5' oligoadenylate synthetase-like 2 2.437536466 0.00154725 0.040836276 1451564_at Parp14 poly (ADP-ribose) polymerase family, member 14 1.688238258 0.000185889 0.0193647 1451969_s_at Parp3 poly (ADP-ribose) polymerase family, member 3 1.868679584 0.002008826 0.046087219 1422474_at Pde4b phosphodiesterase 4B, cAMP specific 2.330238524 0.001427466 0.039499023 1417371_at Peli1 pellino 1 1.589117864 1.82E-05 0.007237237 1417372_a_at Peli1 pellino 1 1.594916151 6.92E-05 0.012660889 1422041_at Pilrb paired immunoglobin-like type 2 receptor beta 0.585022268 0.000809294 0.031282603 1421834_at Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha 0.633823017 3.91E-05 0.010273107 1449404_at Pip5k2a phosphatidylinositol-4-phosphate 5-kinase, type II, alpha 1.280999995 0.00026115 0.020544695 1419279_at Pip5k2a phosphatidylinositol-4-phosphate 5-kinase, type II, alpha 1.25015508 0.000909615 0.032864922 1416387_at Pip5k2c phosphatidylinositol-4-phosphate 5-kinase, type II, gam 1.284638061 7.36E-05 0.013143421 1421325_at Pla2g2f , group IIF 0.790836607 0.000521435 0.025720349 1416530_a_at Pnp purine-nucleoside phosphorylase 0.853849324 0.001156368 0.036090771 1450226_at Prlr prolactin receptor 0.777078597 0.000335483 0.022010729 1426176_a_at Prok2 prokineticin 2 0.853022997 0.000320245 0.021952775 1448355_at Prss16 , serine, 16 (thymus) 0.608237716 0.000660674 0.028874457 1416674_at Ptpru protein tyrosine phosphatase, receptor type, U 0.798234817 0.001167107 0.036261878 1417741_at Pygl liver glycogen phosphorylase 0.666071281 5.43E-06 0.005058848 1449259_at Rab3d RAB3D, member RAS oncogene family 0.784453555 0.001119969 0.035847968 1453200_at Rai1 retinoic acid induced 1 1.335311833 0.000341488 0.022010729 1417856_at Relb avian reticuloendotheliosis viral (v-rel) oncogene related 3.135182012 0.001385814 0.038918915 1448595_a_at Rex3 reduced expression 3 2.568411932 0.000641344 0.028147188 1426443_at Rhbdl7 rhomboid, veinlet-like 7 (Drosophila) 1.318146594 0.000629753 0.028019793 1451516_at Rhebl1 Ras homolog enriched in brain like 1 1.266345132 6.28E-06 0.005058848 1416089_at Rps15 ribosomal protein S15 1.330005398 1.24E-06 0.003195994 1416896_at Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.791838912 0.002180189 0.04798107 1422562_at Rrad Ras-related associated with diabetes 1.691420356 0.002140225 0.047543816 1434437_x_at Rrm2 ribonucleotide reductase M2 0.607776453 1.07E-05 0.005909788 1448226_at Rrm2 ribonucleotide reductase M2 0.59533654 4.36E-05 0.010452948 1425060_s_at Rsn restin (Reed-Steinberg cell-expressed intermediate filam 1.313745773 0.000550819 0.026480594 1421457_a_at Samsn1 SAM domain, SH3 domain and nuclear localisation sign 2.023873632 0.000455421 0.024569357 1438934_x_at Sema4a sema domain, immunoglobulin domain (Ig), transmemb 0.394212667 2.86E-06 0.00432214 1448110_at Sema4a sema domain, immunoglobulin domain (Ig), transmemb 0.5435955 8.04E-06 0.005510144 1424923_at Serpina3g serine (or cysteine) peptidase inhibitor, clade A, membe 3.573943623 5.53E-06 0.005058848 1416318_at Serpinb1a serine (or cysteine) peptidase inhibitor, clade B, membe 0.828147064 0.00220261 0.048173129 1433711_s_at Sesn1 sestrin 1 1.751791448 3.83E-05 0.010273107 1435353_a_at Sfi1 Sfi1 homolog, spindle assembly associated (yeast) 1.620443289 0.00199465 0.045808316 1420819_at Sla src-like adaptor 0.786639371 0.000411708 0.023641622 1417600_at Slc15a2 solute carrier family 15 (H+/peptide transporter), memb 1.474452819 0.000361982 0.022077728 1417061_at Slc40a1 solute carrier family 40 (iron-regulated transporter), mem 0.502740687 0.000727856 0.02980181 1423389_at Smad7 MAD homolog 7 (Drosophila) 1.976404724 0.000474724 0.024707149 1419156_at Sox4 SRY-box containing gene 4 2.849935931 0.001481663 0.040102612 1451542_at Ssbp2 single-stranded DNA binding protein 2 1.958897448 0.001452712 0.039761213 1451063_at Stxbp4 syntaxin binding protein 4 1.638869444 0.001921639 0.044858011 1449389_at Tal1 T-cell acute lymphocytic leukemia 1 2.615092565 0.000780218 0.030681379 1424169_at Tax1bp3 Tax1 (human T-cell leukemia virus type I) binding prote 1.594526698 0.001535835 0.040710402 1423659_a_at Tbc1d17 TBC1 domain family, member 17 1.478133699 0.000374882 0.022478181 1416996_at Tbc1d8 TBC1 domain family, member 8 0.741962646 0.002028889 0.046500506 1434148_at Tcf4 transcription factor 4 2.711295388 1.16E-07 0.001497262 1434149_at Tcf4 transcription factor 4 2.591879199 2.30E-06 0.004011681 1416723_at Tcf4 transcription factor 4 2.52377049 0.001586666 0.040937929 1420614_at Tcte1l t-complex-associated-testis-expressed 1-like 1.396110897 0.000101439 0.014767435 1426716_at Tdrd7 tudor domain containing 7 2.128924736 9.87E-05 0.014767435 1452661_at Tfrc transferrin receptor 0.430389043 0.001527696 0.040589497 1425742_a_at Tgfb1i4 transforming growth factor beta 1 induced transcript 4 2.991485512 0.000427801 0.024208219 1454758_a_at Tgfb1i4 transforming growth factor beta 1 induced transcript 4 1.505900178 0.002305254 0.049416164 1449009_at Tgtp T-cell specific GTPase 1.866057588 0.000232018 0.020034874 1451353_at Tm6sf1 transmembrane 6 superfamily member 1 0.765595178 0.001753369 0.043070681 1416108_a_at Tmed3 transmembrane emp24 domain containing 3 0.536304121 1.03E-05 0.005909788 1452389_at Tnfrsf7 tumor necrosis factor receptor superfamily, member 7 2.446759076 1.01E-05 0.005909788 1415889_a_at Tra1 tumor rejection antigen gp96 0.605002031 0.000943819 0.033257546 1421870_at Trim44 tripartite motif-containing 44 1.338718235 0.000896488 0.03259827 1426784_at Trim47 tripartite motif protein 47 1.309969028 0.001153881 0.036090771 1449041_a_at Trip6 thyroid receptor interactor 6 1.456788068 0.000814633 0.031309804 1427284_a_at Ttpa tocopherol (alpha) transfer protein 1.768391465 0.000212366 0.019463139 1419518_at Tuba8 tubulin, alpha 8 0.597853922 0.001691521 0.042037902 1455205_a_at Usp19 ubiquitin specific peptidase 19 1.265356546 0.000142046 0.017053057 1460621_x_at Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygena 1.232576853 0.00197263 0.045486755 1429615_at Zfp91 zinc finger protein 91 1.269466033 0.001976844 0.045537658 1432167_at 0.802315456 0.001481236 0.040102612 B

MT2 v NHA9 v AE Symbol Description Dnaja3 DnaJ (Hsp40) homolog, subfamily A, member 3 Enam enamelin Mgst1 microsomal glutathione S-transferase 1 Mina myc induced nuclear antigen Mmp2 matrix metallopeptidase 2 Mycbp c-myc binding protein Prlr prolactin receptor Prok2 prokineticin 2 Pygl liver glycogen phosphorylase Rrm2 ribonucleotide reductase M2 Sla src-like adaptor Sox4 SRY-box containing gene 4 Tfrc transferrin receptor Tmed3 transmembrane emp24 domain containing 3

NHA9 v AE Symbol Description 1190002H23Rik RIKEN cDNA 1190002H23 gene Anxa3 annexin A3 Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 Canx calnexin Fabp4 fatty acid binding protein 4, adipocyte Ncam1 neural cell adhesion molecule 1 Ptpru protein tyrosine phosphatase, receptor type, U Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 Usp19 ubiquitin specific peptidase 19

MT2 v NHA9 Symbol Description Dbi diazepam binding inhibitor Serpinb1a serine (or cysteine) peptidase inhibitor, clade B, member 1a MT2 v AE

Symbol Description 1700094D03Rik RIKEN cDNA 1700094D03 gene 4921536K21Rik RIKEN cDNA 4921536K21 gene Abcg2 ATP-binding cassette, sub-family G (WHITE), member 2 Anxa1 Apbb3 amyloid beta (A4) precursor protein-binding, family B, member 3 Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) Atp5h ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d B230354K17Rik RIKEN cDNA B230354K17 gene B2m beta-2 microglobulin BC022651 cDNA sequence BC022651 Bmi1 B lymphoma Mo-MLV insertion region 1 Bri3 brain protein I3 Cd151 CD151 antigen Cdc42se2 CDC42 small effector 2 Cggbp1 CGG triplet repeat binding protein 1 Crlf3 cytokine receptor-like factor 3 Cttn cortactin Dapp1 dual adaptor for phosphotyrosine and 3-phosphoinositides 1 Dhx30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 Dock7 dedicator of cytokinesis 7 Eltd1 EGF, latrophilin seven transmembrane domain containing 1 Eng endoglin Epsti1 epithelial stromal interaction 1 (breast) Etnk1 ethanolamine kinase 1 Fbxo21 F-box only protein 21 Flnb filamin, beta Flot2 flotillin 2 Gabarapl1 gamma-aminobutyric acid (GABA(A)) receptor-associated protein-like 1 Git2 G protein-coupled receptor kinase-interactor 2 Hmgn3 high mobility group nucleosomal binding domain 3 Ipo4 importin 4 Kif3a kinesin family member 3A Ktn1 kinectin 1 Lair1 leukocyte-associated Ig-like receptor 1 Lyst lysosomal trafficking regulator Mansc1 MANSC domain containing 1 Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 Mdfic MyoD family inhibitor domain containing Mef2c myocyte enhancer factor 2C Meis1 myeloid ecotropic viral integration site 1 Midn midnolin Mrpl52 mitochondrial ribosomal protein L52 Ncf1 neutrophil cytosolic factor 1 Nckap1 NCK-associated protein 1 Nedd4 neural precursor cell expressed, developmentally down-regulted gene 4 Nlgn2 neuroligin 2 Parp14 poly (ADP-ribose) polymerase family, member 14 Peli1 pellino 1 Prss16 protease, serine, 16 (thymus) Rab3d RAB3D, member RAS oncogene family Rai1 retinoic acid induced 1 Rhebl1 Ras homolog enriched in brain like 1 Rps15 ribosomal protein S15 Rps6ka1 ribosomal protein S6 kinase polypeptide 1 Rrad Ras-related associated with diabetes Sema4a sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain Serpina3g serine (or cysteine) peptidase inhibitor, clade A, member 3G Slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 Smad7 MAD homolog 7 (Drosophila) Stxbp4 syntaxin binding protein 4 Tbc1d8 TBC1 domain family, member 8 Tcf4 transcription factor 4 Tdrd7 tudor domain containing 7 Trim44 tripartite motif-containing 44 Trip6 thyroid hormone receptor interactor 6 Tuba8 tubulin, alpha 8