Cases in Cardiovascular Medicine*
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The Association Between Blood Pressure Trajectories and Risk of Cardiovascular Diseases Among Non-Hypertensive Chinese Population: a Population-Based Cohort Study
International Journal of Environmental Research and Public Health Article The Association between Blood Pressure Trajectories and Risk of Cardiovascular Diseases among Non-Hypertensive Chinese Population: A Population-Based Cohort Study Fang Li 1,2, Qian Lin 3 , Mingshu Li 3, Lizhang Chen 1,2,*,† and Yingjun Li 4,*,† 1 Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China; [email protected] 2 Hunan Provincial Key Laboratory of Clinical Epidemiology, Changsha 410078, China 3 Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, Changsha 410078, China; [email protected] (Q.L.); [email protected] (M.L.) 4 Department of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou 310053, China * Correspondence: [email protected] (L.C.); [email protected] (Y.L.); Tel.: +86-0731-8883-6996 (L.C.); +86-0571-8769-2815 (Y.L.) † These authors contributed equally to this work and should be considered co-correspondence authors. Abstract: Although previous studies have discussed the association between trajectories of blood pressure (BP) and risk of cardiovascular diseases (CVDs), the association among the non-hypertensive Citation: Li, F.; Lin, Q.; Li, M.; Chen, general population of youth and middle age has not been elucidated. We used the growth mixture L.; Li, Y. The Association between model to explore the trajectories of BP among the non-hypertensive Chinese population and applied Blood Pressure Trajectories and Risk Cox regression to evaluate the association between trajectories of BP and the risk of stroke or of Cardiovascular Diseases among myocardial infarction (MI). -
High Blood Pressure
KNOW THE FACTS ABOUT High Blood Pressure What is high blood pressure? What are the signs and symptoms? Blood pressure is the force of blood High blood pressure usually has no against your artery walls as it circulates warning signs or symptoms, so many through your body. Blood pressure people don’t realize they have it. That’s normally rises and falls throughout the why it’s important to visit your doctor day, but it can cause health problems if regularly. Be sure to talk with your it stays high for a long time. High blood doctor about having your blood pressure pressure can lead to heart disease and checked. stroke—leading causes of death in the United States.1 How is high blood pressure diagnosed? Your doctor measures your blood Are you at risk? pressure by wrapping an inflatable cuff One in three American adults has high with a pressure gauge around your blood pressure—that’s an estimated arm to squeeze the blood vessels. Then 67 million people.2 Anyone, including he or she listens to your pulse with a children, can develop it. stethoscope while releasing air from the cuff. The gauge measures the pressure in Several factors that are beyond your the blood vessels when the heart beats control can increase your risk for high (systolic) and when it rests (diastolic). blood pressure. These include your age, sex, and race or ethnicity. But you can work to reduce your risk by How is it treated? eating a healthy diet, maintaining a If you have high blood pressure, your healthy weight, not smoking, and being doctor may prescribe medication to treat physically active. -
Noninvasive Positive Pressure Ventilation in the Home
Technology Assessment Program Noninvasive Positive Pressure Ventilation in the Home Final Technology Assessment Project ID: PULT0717 2/4/2020 Technology Assessment Program Project ID: PULT0717 Noninvasive Positive Pressure Ventilation in the Home (with addendum) Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 5600 Fishers Lane Rockville, MD 20857 www.ahrq.gov Contract No: HHSA290201500013I_HHSA29032004T Prepared by: Mayo Clinic Evidence-based Practice Center Rochester, MN Investigators: Michael Wilson, M.D. Zhen Wang, Ph.D. Claudia C. Dobler, M.D., Ph.D Allison S. Morrow, B.A. Bradley Beuschel, B.S.P.H. Mouaz Alsawas, M.D., M.Sc. Raed Benkhadra, M.D. Mohamed Seisa, M.D. Aniket Mittal, M.D. Manuel Sanchez, M.D. Lubna Daraz, Ph.D Steven Holets, R.R.T. M. Hassan Murad, M.D., M.P.H. Key Messages Purpose of review To evaluate home noninvasive positive pressure ventilation (NIPPV) in adults with chronic respiratory failure in terms of initiation, continuation, effectiveness, adverse events, equipment parameters and required respiratory services. Devices evaluated were home mechanical ventilators (HMV), bi-level positive airway pressure (BPAP) devices, and continuous positive airway pressure (CPAP) devices. Key messages • In patients with COPD, home NIPPV as delivered by a BPAP device (compared to no device) was associated with lower mortality, intubations, hospital admissions, but no change in quality of life (low to moderate SOE). NIPPV as delivered by a HMV device (compared individually with BPAP, CPAP, or no device) was associated with fewer hospital admissions (low SOE). In patients with thoracic restrictive diseases, HMV (compared to no device) was associated with lower mortality (low SOE). -
Study Guide Medical Terminology by Thea Liza Batan About the Author
Study Guide Medical Terminology By Thea Liza Batan About the Author Thea Liza Batan earned a Master of Science in Nursing Administration in 2007 from Xavier University in Cincinnati, Ohio. She has worked as a staff nurse, nurse instructor, and level department head. She currently works as a simulation coordinator and a free- lance writer specializing in nursing and healthcare. All terms mentioned in this text that are known to be trademarks or service marks have been appropriately capitalized. Use of a term in this text shouldn’t be regarded as affecting the validity of any trademark or service mark. Copyright © 2017 by Penn Foster, Inc. All rights reserved. No part of the material protected by this copyright may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the copyright owner. Requests for permission to make copies of any part of the work should be mailed to Copyright Permissions, Penn Foster, 925 Oak Street, Scranton, Pennsylvania 18515. Printed in the United States of America CONTENTS INSTRUCTIONS 1 READING ASSIGNMENTS 3 LESSON 1: THE FUNDAMENTALS OF MEDICAL TERMINOLOGY 5 LESSON 2: DIAGNOSIS, INTERVENTION, AND HUMAN BODY TERMS 28 LESSON 3: MUSCULOSKELETAL, CIRCULATORY, AND RESPIRATORY SYSTEM TERMS 44 LESSON 4: DIGESTIVE, URINARY, AND REPRODUCTIVE SYSTEM TERMS 69 LESSON 5: INTEGUMENTARY, NERVOUS, AND ENDOCRINE S YSTEM TERMS 96 SELF-CHECK ANSWERS 134 © PENN FOSTER, INC. 2017 MEDICAL TERMINOLOGY PAGE III Contents INSTRUCTIONS INTRODUCTION Welcome to your course on medical terminology. You’re taking this course because you’re most likely interested in pursuing a health and science career, which entails proficiencyincommunicatingwithhealthcareprofessionalssuchasphysicians,nurses, or dentists. -
(Charity Hospital), As a Pathologic Rarity, One Or Two Dr
of the great deal of gas and distress, crying most ANOMALIES OF TUBERCULOSIS IN THE and six stools a day, passing green, irritating day HIGHLANDS OF COLOMBIA which, under the microscope, were seen to contain con¬ siderable fat. The mother had considerable gas in the A NEW DIAGNOSTIC SIGN IN INCIPIENT CASES bowels. The analysis showed: fat, 1.4 per cent.; lactose, 8 per cent., and protein, 1.07 per cent. JORGE VARGAS S., M.D. Although no single component was excessively high, Professor of the General Pathologic Clinic, National University of the relative proportions of the fat, lactose and protein Colombia were abnormal. In this instance after weaning, the NEW YORK a of cow's baby straightened out on simple formula of the of observed milk. Physicians early part this century a curious evolution of tuberculosis in the Colom- In another instance a was being fed by a wet- great baby bian These have an elevation of nurse who also gave her own baby the breast after Highlands. highlands about 11,800 feet above sea level, and are inhabited the foster-baby received what it needed. It was by noticed that the wetnurse's an Indo-Spanish race which numbers very few Indians although baby gained and descendants of the it was uncomfortable and a good part of the many pure conquerors. rapidly, The an of time had stools. As time went on the highlands have average temperature undigested from 14 to 16 C. 57.2 to 60.8 with an inex- fosterbaby did not receive enough milk and was given (or F.), all of the wetnurse's milk. -
Lifetime Risk of Stroke and Impact of Hypertension: Estimates from the Adult Health Study in Hiroshima and Nagasaki
Hypertension Research (2011) 34, 649–654 & 2011 The Japanese Society of Hypertension All rights reserved 0916-9636/11 $32.00 www.nature.com/hr ORIGINAL ARTICLE Lifetime risk of stroke and impact of hypertension: estimates from the adult health study in Hiroshima and Nagasaki Ikuno Takahashi1,4, Susan M Geyer2,6, Nobuo Nishi3,7, Tomohiko Ohshita4, Tetsuya Takahashi4, Masazumi Akahoshi1, Saeko Fujiwara1, Kazunori Kodama5 and Masayasu Matsumoto4 Very few reports have been published on lifetime risk (LTR) of stroke by blood pressure (BP) group. This study included participants in the Radiation Effects Research Foundation Adult Health Study who have been followed up by biennial health examinations since 1958. We calculated the LTR of stroke for various BP-based groups among 7847 subjects who had not been diagnosed with stroke before the index age of 55 years using cumulative incidence analysis adjusting for competing risks. By 2003, 868 subjects had suffered stroke (512 (58.9%) were women and 542 (62.4%) experienced ischemic stroke). BP was a significant factor in determining risk of stroke for men and women, with distributions of cumulative risk for stroke significantly different across BP groups. The LTR of all-stroke for normotension (systolic BP/diastolic BP o120/80 mm Hg), prehypertension (120–139/80–89 mm Hg), stage1 hypertension (140–159/90–99 mm Hg) and stage 2 hypertension (4160/100 mm Hg) were 13.8–16.9–25.8–25.8% in men and 16.0–19.9–24.0–30.5% in women, respectively (Po0.001 among BP groups in both sexes). The estimates did not differ significantly (P¼0.16) between normotensive and prehypertensive subjects. -
The Multiple Lifestyle Modification for Patients With
Open Access Protocol BMJ Open: first published as 10.1136/bmjopen-2014-004920 on 14 August 2014. Downloaded from The multiple lifestyle modification for patients with prehypertension and hypertension patients: a systematic review protocol Juan Li,1 Hui Zheng,1 Huai-bin Du,2 Xiao-ping Tian,2 Yi-jing Jiang,3 Shao-lan Zhang,4 Yu Kang,5 Xiang Li,2 Jie Chen,1 Chao Lu,1 Zhen-hong Lai,1 Fan-rong Liang1 To cite: Li J, Zheng H, ABSTRACT et al Strengths and limitations of this study Du H-bin, . The multiple Introduction: The objective of this systematic review lifestyle modification for is to investigate the effectiveness, efficacy and safety ▪ patients with prehypertension To the best of our knowledge, this is the first of multiple concomitant lifestyle modification and hypertension patients: a systematic review to investigate the effectiveness, systematic review protocol. therapies for patients with hypertension or efficacy and safety of multiple lifestyle changes BMJ Open 2014;4:e004920. prehypertension. for patients with hypertension. doi:10.1136/bmjopen-2014- Methods and analysis: Electronic searches will be ▪ The results of this systematic review can provide 004920 performed in the Cochrane Library, OVID, EMBASE, clinicians with useful clinical information to etc, along with manual searches in the reference lists guide their patient care and increase the under- ▸ Prepublication history for of relevant papers found during electronic search. We standing of lifestyle modifications, as well as this paper is available online. will identify eligible randomised controlled trials motivate patients with hypertension to adopt and To view these files please utilising multiple lifestyle modifications to lower blood maintain multiple lifestyle changes. -
Respiratory Insufficiency in Patients with ALS at Or Near the End of Life
Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease causing progressive paralysis and eventual death, usually from respiratory failure. Treatment for ALS is focused primarily on optimal symptom manage- ment because there is no known cure. Respiratory symptoms that occur are related to the disease process and can be very distressing for patients and their loved ones. Recommendations on the management of respira- tory insufficiency are provided to help guide clinicians caring for patients with ALS. Hospice and Palliative Care Feature The Management of Andrea L. Torres, APN, CNP Respiratory Insufficiency in Patients With ALS at or Near the End of Life 186 Home Healthcare Nurse www.homehealthcarenurseonline.com Copyright © 2012 Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. Introduction 2007). By the time most patients are definitively Amyotrophic lateral sclerosis (ALS) is a devastat- diagnosed, they are often already in an advanced ing motor neuron disease characterized by pro- stage of the disease (Wood-Allum & Shaw, 2010). gressive muscle weakness eventually leading to Life expectancy is typically 3-5 years from the paralysis and death. The onset typically occurs onset of symptoms (Elman et al., 2007). in late middle age, with men slightly more af- fected than women (Wood-Allum & Shaw, 2010). Palliative Care Approaches for ALS Patients The majority of cases of ALS have no known Due to the progressive nature of ALS, early pal- cause; about 10% of ALS cases are linked to a fa- liative care is an essential component in the milial trait (Ferguson & Elman, 2007). Treatment treatment plan, and should begin as soon as the is primarily focused on optimal symptom man- diagnosis of ALS is confirmed (Elman et al., 2007). -
CT Children's CLASP Guideline
CT Children’s CLASP Guideline Chest Pain INTRODUCTION . Chest pain is a frequent complaint in children and adolescents, which may lead to school absences and restriction of activities, often causing significant anxiety in the patient and family. The etiology of chest pain in children is not typically due to a serious organic cause without positive history and physical exam findings in the cardiac or respiratory systems. Good history taking skills and a thorough physical exam can point you in the direction of non-cardiac causes including GI, psychogenic, and other rare causes (see Appendix A). A study performed by the New England Congenital Cardiology Association (NECCA) identified 1016 ambulatory patients, ages 7 to 21 years, who were referred to a cardiologist for chest pain. Only two patients (< 0.2%) had chest pain due to an underlying cardiac condition, 1 with pericarditis and 1 with an anomalous coronary artery origin. Therefore, the vast majority of patients presenting to primary care setting with chest pain have a benign etiology and with careful screening, the patients at highest risk can be accurately identified and referred for evaluation by a Pediatric Cardiologist. INITIAL INITIAL EVALUATION: Focused on excluding rare, but serious abnormalities associated with sudden cardiac death EVALUATION or cardiac anomalies by obtaining the targeted clinical history and exam below (red flags): . Concerning Pain Characteristics, See Appendix B AND . Concerning Past Medical History, See Appendix B MANAGEMENT . Alarming Family History, See Appendix B . Physical exam: - Blood pressure abnormalities (obtain with manual cuff, in sitting position, right arm) - Non-innocent murmurs . Obtain ECG, unless confident pain is musculoskeletal in origin: - ECG’s can be obtained at CT Children’s main campus and satellites locations daily (Hartford, Danbury, Glastonbury, Shelton). -
A Case of Extreme Hypercapnia
119 Emerg Med J: first published as 10.1136/emj.2003.005009 on 20 January 2004. Downloaded from CASE REPORTS A case of extreme hypercapnia: implications for the prehospital and accident and emergency department management of acutely dyspnoeic patients L Urwin, R Murphy, C Robertson, A Pollok ............................................................................................................................... Emerg Med J 2004;21:119–120 64 year old woman was brought by ambulance to the useful non-invasive technique to aid the assessment of accident and emergency department. She had been peripheral oxygen saturation. In situations of poor perfusion, Areferred by her GP because of increasing dyspnoea, movement and abnormal haemoglobin, however, this tech- cyanosis, and lethargy over the previous four days. On arrival nique may not reliably reflect PaO2 values. More importantly, of the ambulance crew at her home she was noted to be and as shown in our case, there is no definite relation tachycardic and tachypnoeic (respiratory rate 36/min) with a between SaO2 values measured by pulse oximetry and PaCO2 GCS of 5 (E 3, M 1, V 1). She was given oxygen at 6 l/min via values although it has been shown that the more oxygenated a Duo mask, and transferred to hospital. The patient arrived at the accident and emergency department 18 minutes later. In transit, there had been a clinical deterioration. The GCS was now 3 and the respiratory rate 4/min. Oxygen saturation, as measured by a pulse oximeter was 99%. The patient was intubated and positive pressure ventilation started. Arterial blood gas measurements taken at the time of intubation were consistent with acute on chronic respiratory failure (fig 1). -
CARDIOLOGY Section Editors: Dr
2 CARDIOLOGY Section Editors: Dr. Mustafa Toma and Dr. Jason Andrade Aortic Dissection DIFFERENTIAL DIAGNOSIS PATHOPHYSIOLOGY (CONT’D) CARDIAC DEBAKEY—I ¼ ascending and at least aortic arch, MYOCARDIAL—myocardial infarction, angina II ¼ ascending only, III ¼ originates in descending VALVULAR—aortic stenosis, aortic regurgitation and extends proximally or distally PERICARDIAL—pericarditis RISK FACTORS VASCULAR—aortic dissection COMMON—hypertension, age, male RESPIRATORY VASCULITIS—Takayasu arteritis, giant cell arteritis, PARENCHYMAL—pneumonia, cancer rheumatoid arthritis, syphilitic aortitis PLEURAL—pneumothorax, pneumomediasti- COLLAGEN DISORDERS—Marfan syndrome, Ehlers– num, pleural effusion, pleuritis Danlos syndrome, cystic medial necrosis VASCULAR—pulmonary embolism, pulmonary VALVULAR—bicuspid aortic valve, aortic coarcta- hypertension tion, Turner syndrome, aortic valve replacement GI—esophagitis, esophageal cancer, GERD, peptic OTHERS—cocaine, trauma ulcer disease, Boerhaave’s, cholecystitis, pancreatitis CLINICAL FEATURES OTHERS—musculoskeletal, shingles, anxiety RATIONAL CLINICAL EXAMINATION SERIES: DOES THIS PATIENT HAVE AN ACUTE THORACIC PATHOPHYSIOLOGY AORTIC DISSECTION? ANATOMY—layers of aorta include intima, media, LR+ LRÀ and adventitia. Majority of tears found in ascending History aorta right lateral wall where the greatest shear force Hypertension 1.6 0.5 upon the artery wall is produced Sudden chest pain 1.6 0.3 AORTIC TEAR AND EXTENSION—aortic tear may Tearing or ripping pain 1.2–10.8 0.4–0.99 produce -
Chapter 17 Dyspnea Sabina Braithwaite and Debra Perina
Chapter 17 Dyspnea Sabina Braithwaite and Debra Perina ■ PERSPECTIVE Pathophysiology Dyspnea is the term applied to the sensation of breathlessness The actual mechanisms responsible for dyspnea are unknown. and the patient’s reaction to that sensation. It is an uncomfort- Normal breathing is controlled both centrally by the respira- able awareness of breathing difficulties that in the extreme tory control center in the medulla oblongata, as well as periph- manifests as “air hunger.” Dyspnea is often ill defined by erally by chemoreceptors located near the carotid bodies, and patients, who may describe the feeling as shortness of breath, mechanoreceptors in the diaphragm and skeletal muscles.3 chest tightness, or difficulty breathing. Dyspnea results Any imbalance between these sites is perceived as dyspnea. from a variety of conditions, ranging from nonurgent to life- This imbalance generally results from ventilatory demand threatening. Neither the clinical severity nor the patient’s per- being greater than capacity.4 ception correlates well with the seriousness of underlying The perception and sensation of dyspnea are believed to pathology and may be affected by emotions, behavioral and occur by one or more of the following mechanisms: increased cultural influences, and external stimuli.1,2 work of breathing, such as the increased lung resistance or The following terms may be used in the assessment of the decreased compliance that occurs with asthma or chronic dyspneic patient: obstructive pulmonary disease (COPD), or increased respira- tory drive, such as results from severe hypoxemia, acidosis, or Tachypnea: A respiratory rate greater than normal. Normal rates centrally acting stimuli (toxins, central nervous system events).