(CHEM) 1

CHEM-202 I CHEMISTRY (CHEM) Fall and Spring. Credits: 4 This course introduces the core principles of the language of organic CHEM-150 : Foundations of Structure and Reactivity chemistry and extends their use to the description of the behavior and Fall and Spring. Credits: 4 reactivity of carbonyl containing functional groups. Topics include This course provides an introduction to the fundamental concepts of representation and naming, the use of various spectroscopic approaches chemistry, including the electronic structure of and , to probe molecular structure, an overview of bonding models and chemical bonding, molecular shape, functional groups, stoichiometry, molecular geometry, the development of mechanistic drawing, and the chemical reactivity and equilibrium. The laboratory emphasizes basic application of this mechanistic approach to the reactions of a wide skills, quantitative chemical measurements, and principles discussed in range of carbonyl compounds. The accompanying laboratory course lectures. introduces a range of essential analytical, preparative and purification Applies to requirement(s): Math Sciences techniques, provides practice in the interpretation of spectroscopic data, K. Berry, W. Chen, D. Hamilton, M. Gomez and culminates with the preparation of organic materials related to the Coreq: CHEM-150L. lecture course. Notes: This course is offered in both fall and spring semesters. Applies to requirement(s): Math Sciences CHEM-160 Integrated Introduction to Biology and Chemistry D. Hamilton, G. Snyder Fall. Credits: 4 Prereq: CHEM-150, or CHEM-160, or CHEM-101 and CHEM-201. Coreq: This 8-credit course serves as a gateway to both the biology and CHEM-202L. chemistry core curricula. The course introduces and develops CHEM-223 fundamental concepts in chemistry while also exploring the diverse Not Scheduled for This Year. Credits: 4 range of strategies adopted by living systems to survive in different This course serves as an introduction to quantitative analytical chemistry, environments. This course prepares students for further study in with a combined emphasis on both classical analysis tools and chemistry and/or biology (Biology 200). Students must register for fundamental instrumentation for the analytical . Topics to be both Biology 160 and Chemistry 160 as well as a single lab section covered include figures of merit, statistical and error analysis, volumetric (listed under Chemistry 160). Recommended for students interested in and gravimetric , as well as commonly used sample preparation completing pre-health requirements or advanced study in or and analyte separation methods.In the laboratory, students will apply neuroscience. techniques covered in lecture to quantitation of analytes commonly seen Applies to requirement(s): Math Sciences in pharmaceutical, forensic, chemical and biological settings, as well as W. Chen learn the fundamentals of method development and optimization. Restrictions: This course is limited to first-year students. Applies to requirement(s): Math Sciences Coreq: BIOL-160 and CHEM-160L. J. Ashby, W. Chen Notes: Students must co-enroll in Biology 160 and Chemistry 160 for a total Prereq: CHEM-201 with a grade of C or better. Coreq: CHEM-223L. of 8 credits; three 50 minute lectures, three 75 minute lectures, and one three- CHEM-231 hour laboratory per week. Fall and Spring. Credits: 4 CHEM-199 Introduction to Research An introduction to the chemistry of elements. Topics include atomic Spring. Credits: 4 structure and periodicity, symmetry, bonding theory, chemistry of the This seminar is for first-year students who have a strong interest in the main-group elements and coordination chemistry. Laboratory introduces chemical sciences and will help to prepare them for scientific research. computational, preparative, and spectroscopic techniques. Students will be exposed to various research topics through reading, Applies to requirement(s): Math Sciences discussing, presenting, and writing about primary literature and attending D. Cotter selected department seminars. Throughout the semester students will Prereq: CHEM-150 (or CHEM-160) and MATH-101. Coreq: CHEM-231L. carry out one research-style project in order to gain experience with the CHEM-291 Scientific Illustration and Data Visualization multifaceted nature of scientific inquiry. To jump start their research Not Scheduled for This Year. Credits: 4 career on campus, each student will arrange meetings with at least two Doing experiments and gathering data are important, but far from the science faculty followed by a presentation and a written description on entirety of the scientific process. Understanding and communicating the faculty members' research topics. experimental outcomes often heavily rely on our ability to visually Applies to requirement(s): Meets No Distribution Requirement represent them. In this course, we will explore best practices for W. Chen organizing and representing data, and learn how the choices we make Restrictions: This course is limited to first-year students. influence the message our representations communicate. We will also Instructor permission required. develop a set of good design principles for scientific figures, and learn to Prereq: CHEM-150 or CHEM-160. prepare high quality plots and graphics for use in presentations, posters, Advisory: Interested students should complete the online application. reports, theses, and papers. Applies to requirement(s): Math Sciences K. Broaders Prereq: 8 credits in a STEM subject. 2 Chemistry (CHEM)

CHEM-295 Independent Study CHEM-311 Protein Biochemistry and Cellular Metabolism Fall and Spring. Credits: 1 - 4 Fall. Credits: 4 The department This course is a rigorous introduction to the study of protein molecules Instructor permission required. and their role as catalysts of the cell. Topics include general principles Notes: Note: Students conducting an independent laboratory research project of protein folding, protein structure-function correlation, enzyme kinetics for course credit in a department, program, or laboratory covered by the and mechanism, carbohydrate and lipid biochemistry, and metabolic College's chemical hygiene plan must participate in a safety training session pathways (catabolic and anabolic) and their interaction and cross- before beginning research. regulation. Biological transformation of energy is considered in light of CHEM-302 Organic Chemistry II the principle of thermodynamics. Fall. Credits: 4 Crosslisted as: BIOCH-311, BIOL-311 This course provides a direct continuation of Organic Chemistry I Applies to requirement(s): Math Sciences (CHEM-202) and develops and extends many of the concepts and K. Berry approaches developed therein. Topics include , Restrictions: This course is limited to Biochemistry majors only. substitution and elimination reactions, conformational analysis, Prereq: BIOL-230, and CHEM-302, and CHEM-231. Coreq: BIOCH-318. addition reactions of multiple bonds, substitution reactions of aromatic CHEM-312 Chemistry of Biomolecules systems, and a broad extension of the carbonyl chemistry introduced Fall. Credits: 4 in the preceding class. Consideration will be given to the development An examination of the major ideas of biochemistry from the point of of organic syntheses of specific materials and attendant issues of view of the chemical sciences rather than the life sciences. The focus compatibility and selectivity in reaction choice. The scope and reach will be on structure and reactivity of important biomolecules and the of the spectroscopic methods introduced in Organic Chemistry I will role of energetics and reaction dynamics in biochemical processes. be extended and applied to structure determination. Laboratory work Major metabolic pathways are covered, including those of proteins, will include the preparation, isolation and purification of a wide range of carbohydrates, lipids, and nucleic acids. organic materials of relevance to the lecture course. Crosslisted as: BIOCH-312 Applies to requirement(s): Math Sciences Applies to requirement(s): Math Sciences D. Hamilton T. Tashjian Prereq: CHEM-202 with grade of C or better. Coreq: CHEM-302L. Prereq: CHEM-202 with a grade of C or better. CHEM-308 with Lab Advisory: This course is NOT intended for biochemistry majors, who must Fall. Credits: 4 take BIOCH-311 and BIOCH-314. CHEM-312 students may take BIOCH-318 A consideration of the contribution of thermodynamics to the concurrently. understanding of the 'driving forces' for physical chemical changes CHEM-314 Nucleic Acids Biochemistry and and the nature of the equilibrium state. Topics will include statistical Spring. Credits: 4 mechanics, thermodynamics, and kinetics. This course is an in-depth examination of DNA and RNA structures Applies to requirement(s): Math Sciences and how these structures support their respective functions during A. van Giessen replication, transcription, and translation of the genetic material. Prereq: MATH-203 or PHYS 205, and CHEM-223 or CHEM-231, all with grade of Emphasis is on the detailed mechanisms associated with each step of C or better. Coreq: CHEM-308L. gene expression. Discussions incorporate many recent advances brought CHEM-309 Introduction to Materials about by recombinant DNA technology. Not Scheduled for This Year. Credits: 4 Crosslisted as: BIOCH-314, BIOL-314 This integrated lecture/lab course provides an introduction to different Applies to requirement(s): Math Sciences types of materials, including metals, ceramics, polymers, and composites, K. Berry emphasizing structure and property relationships. The principles behind Restrictions: This course is limited to Biochemistry majors only. the design and implementation of materials as well as advances in Prereq: BIOCH-311. Coreq: CHEM-314L. materials in the areas of nano-, bio-, and electronic technology will be Advisory: CHEM-302 can be taken concurrently presented. Class time is split among lecture, discussion, and laboratory. CHEM-314WT Nucleic Acids Biochemistry and Molecular Biology Applies to requirement(s): Math Sciences Not Scheduled for This Year. Credits: 4 W. Chen This course is an in-depth examination of DNA and RNA structures Prereq: CHEM-201 or CHEM-231, CHEM-202, and MATH-101 and how these structures support their respective functions during replication, transcription, and translation of the genetic material. Emphasis is on the detailed mechanisms associated with each step of gene expression. Discussions incorporate many recent advances brought about by recombinant DNA technology. Applies to requirement(s): Math Sciences K. Berry Restrictions: This course is limited to Biochemistry majors only. Prereq: BIOCH-311. Chemistry (CHEM) 3

CHEM-316 CHEM-326 Poisons: Death by Chemistry Not Scheduled for This Year. Credits: 4 Fall. Credits: 4 The field of chemical biology applies chemical perspectives and tools This course uses a Problem-Based Learning approach to look at the to the study of biological systems. In this course, we will examine effect of poisons at the molecular, cellular, and physiological levels the ways that synthetic chemistry has provided techniques that from the chemistry and biochemistry perspective. We'll discuss: the support, complement, and expand on those used in biochemistry, drug classification of poisons and the common structural elements of discovery, and molecular and . Topics may include solid the molecules within each class; the interaction of toxic molecules phase biomolecule synthesis, , bioconjugation, with proteins and nucleic acids present in the cell; the physiologic molecular probes, protein engineering, drug delivery, and synthetic effect of toxins on different systems of the body; dosage effects and biology. pharmacokinetics; the mechanisms by which antidotes work; and the Applies to requirement(s): Math Sciences analytical techniques that toxicologists use to determine which poisons K. Broaders are present in the body. The different classes of poisons will be discussed Prereq: CHEM-302 and any other 300-level chemistry or biochemistry course. in the context of historical case studies. CHEM-317 Principles of Applies to requirement(s): Math Sciences Not Scheduled for This Year. Credits: 4 A. van Giessen An introduction to the study of molecules of high molecular weights with Prereq: Any 200-level Chemistry course. emphasis on synthetic rather than naturally occurring polymers. Topics Advisory: Students who have taken CHEM-226 may not enroll in CHEM-326. include polymer syntheses, structures, and characterization. CHEM-329 Cosmetic Chemistry Applies to requirement(s): Math Sciences Not Scheduled for This Year. Credits: 4 W. Chen This course will introduce the chemistry, formulation, and physical Prereq: CHEM-302. characteristics of personal care products. The topics will include basic CHEM-321 skin physiology, hygiene products, adornment products for face, nail, and Not Scheduled for This Year. Credits: 4 hair, as well as current trends and advances in cosmetic dermatology. An Forensic apply their knowledge of analytical chemistry to the integral part of the course will involve hands-on experience in making and identification of trace unknowns present in a crime scene. In this course, characterizing some common skincare and cosmetic products. the function of chemical instrumentation such as , Applies to requirement(s): Math Sciences , and microscopy will be discussed. In addition, we will W. Chen investigate how this instrumentation can be used for the analysis of Prereq: CHEM-302. various types of physical evidence, such as inks, fibers, drugs, and CHEM-330 Advanced Topics in Chemistry arson/explosion evidence. Finally, this course will also serve as a brief CHEM-330RN Advanced Topics in Chemistry: 'The RNA World: The Origin introduction to pharmacokinetics, as well as an introduction to concepts of Life to Modern Cells' within forensic science such as expert testimony and quality assurance Not Scheduled for This Year. Credits: 4 of forensic analysis. RNA is believed by many to have been the first macromolecule to evolve. Applies to requirement(s): Math Sciences In a hypothesized "RNA world," RNA would have simultaneously served Other Attribute(s): Speaking-Intensive the roles of carrying genetic information and catalyzing chemical J. Ashby reactions within early cells. The past three decades have been a Prereq: CHEM-202 and CHEM-223. renaissance for RNA biology, as researchers have uncovered the critical CHEM-325 Atomic and Molecular Structure with Lab role RNA plays in eukaryotic and bacterial gene regulation and defense, Not Scheduled for This Year. Credits: 4 as well as the potential for RNAs to perform . This seminar will This course is an introduction to experimental and theoretical introduce students to modern approaches to study the structure and approaches to the determination of the structure of atoms, molecules, function of RNA and will explore the chemical and biological roles RNA and chemical bonds. Classroom work provides background in the theory plays in modern cells as well as its role in the origin of life. of atomic and molecular structure and an introduction to quantum Crosslisted as: BIOCH-330RN mechanics and spectroscopy. Applies to requirement(s): Math Sciences Applies to requirement(s): Math Sciences Other Attribute(s): Speaking-Intensive M. Gomez K. Berry Prereq: MATH-203 or PHYS-205, and CHEM-223 or CHEM-231, all with grade of Prereq: BIOCH-311, or BIOCH-314, or CHEM-312. C or better. Coreq: CHEM-325L. CHEM-336 Organic Synthesis Advisory: MATH-203 is recommended. Not Scheduled for This Year. Credits: 4 This course emphasizes recent developments in synthetic organic chemistry and deals with general synthetic methods and specific examples of natural product synthesis. It covers such topics as new methods of oxidation and reduction, stereospecific olefin formation, ring- forming reactions, and methods of carbon-carbon bond formation. The application of these reactions to the synthesis of naturally occurring compounds is examined. A general strategy for the synthesis of complex molecules is also presented. Applies to requirement(s): Math Sciences K. Broaders Prereq: CHEM-302. 4 Chemistry (CHEM)

CHEM-339 The Organic Chemistry of Biological Pathways CHEM-349 : the Science of the Kitchen Not Scheduled for This Year. Credits: 4 Not Scheduled for This Year. Credits: 4 This course explores the underlying organic chemistry of biological Food Chemistry is an integrated lecture/lab course that focuses on pathways and thereby seeks to build a framework for understanding the molecular bases of chemical phenomena that dictate the behavior biological transformations from the perspective of mechanistic organic of foods. We will examine topics such as trans fats, baking soda as chemistry. Beginning with common biological mechanisms, and drawing a leavening agent in baking, the chemical basis for ripening of fruit, parallels with their sophomore organic chemistry counterparts, a broad pectin as a cellular glue, artificial sweeteners, GMOs, and enzymatic overview will be constructed of the pathways by which the key classes of and non-enzymatic browning of foods. The emphasis is on the major biological molecules--lipids, carbohydrates, amino acids, nucleotides--are food components (water, lipids, proteins, and carbohydrates) and their manufactured, modified, and consumed. Several specific biosyntheses behavior under various conditions. Content will be discussed using a will also be dissected from a mechanistic perspective. These case variety of contexts including primary scientific literature, mainstream studies will include antibiotics, an alkaloid, and heme. media, and food blogs. Laboratories provide opportunities for students Applies to requirement(s): Math Sciences to observe, manipulate, and explore topics in food chemistry under D. Hamilton conditions of particular relevance to food processing. Instructor permission required. Applies to requirement(s): Math Sciences Prereq: CHEM-302. K. McMenimen CHEM-346 of Biochemical Systems With Lab Prereq: CHEM-302 with a grade of C or better. Not Scheduled for This Year. Credits: 4 CHEM-395 Independent Study This course provides an overview of the fundamental principles of Fall and Spring. Credits: 1 - 8 physical chemistry with an emphasis on their application to the study The department of biological molecules and processes. Topics will include statistical Instructor permission required. mechanics, thermodynamics and enzyme kinetics. Discussion of Notes: See safety training restrictions in description of Chemistry 295 applications will relate commonly used experimental techniques -- such as spectroscopy and -- to the fundamental principles on which they are based. In addition, students will gain experience and confidence in the use of mathematical models to describe biochemical systems. Applies to requirement(s): Math Sciences A. van Giessen Restrictions: This course is limited to Biochemistry majors only. Prereq: MATH-203 or PHYS-205, and CHEM-223 or CHEM-231, all with a grade of C or better. Coreq: CHEM-346L. CHEM-348 Using Data Science to Find Hidden Chemical Rules Spring. Credits: 4 Chemists have always been interested in understanding patterns in their data. The scientific method uses observations to create theories and models to understand physical phenomena. Data science algorithms allow us to find unexpected patterns in chemical data. New chemical theories can be developed using a combination of data from either experiment or simulation, algorithms and physical insight. This class uses the case method providing three challenge problems to find hidden chemical rules from large chemical data sets through algorithms and physical insight. There will be lectures on the physical/chemical problems, the data sets, and the possible algorithms to consider before the teams of students tackle these problems. The teams will write papers on their findings and use the peer review process to improve their papers. Applies to requirement(s): Math Sciences Other Attribute(s): Writing-Intensive M. Gomez Prereq: MATH-102 and either any chemistry or any computer science class.