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NO Synthase Nitric Oxide Synthases; NOS

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NO Synthase Nitric Oxide Synthases; NOS NO Synthase Nitric oxide synthases; NOS Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases. www.MedChemExpress.com 1 NO Synthase Inhibitors, Agonists, Antagonists & Activators (S)-MRI-1867 1400W Dihydrochloride Cat. No.: HY-141411A Cat. No.: HY-18731 (S)-MRI-1867 is a peripherally restricted, orally 1400W dihydrochloride is a potent and selective bioavailable dual cannabinoid CB1 receptor and inhibitor of human inducible NO synthase with Ki inducible NOS (iNOS) antagonist. (S)-MRI-1867 values of 7 nM. ameliorates obesity-induced chronic kidney disease (CKD). Purity: >98% Purity: 99.65% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg 2,4-Diamino-6-hydroxypyrimidine 2-Iminobiotin Cat. No.: HY-100954 (Guanidinobiotin) Cat. No.: HY-118700 2,4-Diamino-6-hydroxypyrimidine is a specific GTP 2-Iminobiotin (Guanidinobiotin) is a biotin cyclohydrolase I inhibitor (the rate-limiting (vitamin H or B7) analog. 2-Iminobiotin is a enzyme in de novo pterin synthesis). reversible nitric oxide synthases inhibitor with 2,4-Diamino-6-hydroxypyrimidine blocks Kis of 21.8 and 37.5μM for murine iNOS and rat Tetrahydrobiopterin (BH4) synthesis and suppresses n-cNOS, respectively. NO production. Purity: 99.97% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10 mM × 1 mL, 100 mg Size: 10 mM × 1 mL, 5 mg 2-Iminobiotin hydrobromide 3',4'-Dihydroxyflavonol (Guanidinobiotin hydrobromide) Cat. No.: HY-118700A (DiOHF) Cat. No.: HY-111804 2-Iminobiotin hydrobromide (Guanidinobiotin 3',4'-Dihydroxyflavonol (DiOHF) is an effective hydrobromide) is a biotin (vitamin H or B7) antioxidant, which reduces superoxide and improves analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide (NO) function in diabetic rat nitric oxide synthases inhibitor with Kis of 21.8 mesenteric arteries. and 37.5 μM for murine iNOS and rat n-cNOS, respectively. Purity: ≥98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg Size: 1 mg, 5 mg 3-Bromo-7-nitroindazole 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid Cat. No.: HY-101175 Cat. No.: HY-N2989 3-Bromo-7-nitroindazole is a more potent and 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid, an selective inhibitor of neuronal nitric oxide anti-inflammatory triterpenoid, inhibits NO synthase (nNOS) than eNOS or inducible nitric production and iNOS expression in LPS-stimulated oxide synthase (iNOS). 3-Bromo-7-nitroindazole Raw264.7 cells. affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain. Purity: 98.12% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg 6-Biopterin 7,8-Dihydroneopterin (L-Biopterin) Cat. No.: HY-102015 Cat. No.: HY-136341 6-Biopterin (L-Biopterin), a pterin derivative, is 7,8-Dihydroneopterin, an inflammation marker, a NO synthase cofactor. induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases. Purity: ≥98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 1 mg, 5 mg 2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] 7-Ethoxyresorufin Agmatine sulfate (Resorufin ethyl ether) Cat. No.: HY-D0145 Cat. No.: HY-101238 7-Ethoxyresorufin (Resorufin ethyl ether) is a Agmatine sulfate exerts modulatory action at fluorometric substrate and competitive inhibitor multiple molecular targets, such as of cytochrome P450, especially CYP1A1. neurotransmitter systems, ion channels and nitric 7-Ethoxyresorufin also inhibits NO synthase. oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. Purity: >98% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg, 500 mg, 1 g Anemarsaponin B AR-C102222 hydrochloride Cat. No.: HY-N0811 Cat. No.: HY-12122A Anemarsaponin B is a steroidal saponin isolated AR-C102222 hydrochloride is a potent, competitive, from the rhizomes of A. asphodeloides (Liliaceae). orally active and highly selective inducible nitric Anemarsaponin B decreases the protein and mRNA oxide synthase (iNOS) inhibitor, with an IC50 of 37 levels of iNOS and COX-2. nM. AR-C102222 hydrochloride has antinociception and anti-inflammatory activities. Purity: >98% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 10 mM × 1 mL, 1 mg, 5 mg, 10 mg Asperuloside Asymmetric dimethylarginine Cat. No.: HY-N1382 Cat. No.: HY-113216 Asperuloside is an iridoid isolated from Hedyotis Asymmetric dimethylarginine is an endogenous diffusa, with anti-inflammatory activity. inhibitor of nitric oxide synthase (NOS), and Asperuloside inhibits inducible nitric oxide functions as a marker of endothelial dysfunction synthase (iNOS), suppresses NF-κB and MAPK in a number of pathological states. signaling pathways. Purity: 99.69% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 20 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg AVE3085 BBS-4 Cat. No.: HY-19504 Cat. No.: HY-12124 AVE3085 is a potent endothelial nitric oxide BBS-4 is a potent and selective inducible nitric synthase enhancer, used for cardiovascular oxide synthase (NOS2) dimerization inhibitor, disease treatment. with an IC50 of 0.49 nM. BBS-4 can protect mice from the cardiovascular dysfunction of sepsis. Purity: 99.95% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg Bendazol Camstatin Cat. No.: HY-B2141 Cat. No.: HY-P0184 Bendazol is a hypotensive drug which can also Camstatin, a functionally active 25-residue enhance NO synthase activity in renal glomeruli fragment of PEP-19's IQ motif, binds calmodulin and collecting tubules. and inhibits neuronal nitric oxide (NO) synthase. Purity: 99.45% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 500 mg Size: 1 mg, 5 mg www.MedChemExpress.com 3 Camstatin TFA Carboxy-PTIO potassium Cat. No.: HY-P0184A Cat. No.: HY-18734A Camstatin TFA, a functionally active 25-residue Carboxy-PTIO potassium is a potent nitric oxide fragment of PEP-19's IQ motif, binds calmodulin (NO) scavenger that can make a quick and inhibits neuronal nitric oxide (NO) synthase. reaction with NO to produce NO2. Carboxy-PTIO potassium can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg Chondroitin sulfate Ciwujianoside C3 (Chondroitin polysulfate) Cat. No.: HY-B2162 Cat. No.: HY-N4134 Chondroitin sulfate, one of five classes of Ciwujianoside C3, an orally active and brain glycosaminoglycans, has been widely used in the penetrated compound, is isolated the leaves of treatment of osteoarthritis. Chondroitin sulfate Acanthopanax henryi Harms. reduces inflammation mediators and the apoptotic Ciwujianoside C3 has anti-inflammatory effect process and is able to reduce protein production and can reinforces object recognition memory. of inflammatory cytokines, iNOS and MMPs. Purity: >98% Purity: ≥98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 250 mg, 1 g Size: 10 mM × 1 mL, 5 mg Crocin II Curvularin Cat. No.: HY-N0698 ((S)-Curvularin) Cat. No.: HY-N6770 Crocin II is isolated from the fruit of Gardenia Curvularin, a fungal metabolite and a potent jasminoides with antioxidant, anticancer, and mycotoxin naturally isolated from Curvularia lunata, antidepressant activity. Crocin II inhibits NO inhibits cytokine-induced nitric oxide synthase production with an IC50 value of 31.1 μM. Crocin (iNOS), with an IC50 of 9.5 µM. II suppresses the expressions of protein and m-RNA of iNOS and COX-2. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg Dehydroevodiamine Dimaprit dihydrochloride Cat. No.: HY-N2106 Cat. No.: HY-B1478 Dehydroevodiamine is a major bioactive quinazoline Dimaprit dihydrochloride is a selective alkaloid isolated from Evodiae Fructus, has an histamine H2 receptor agonist, it also antiarrhythmic effect in guinea-pig ventricular inhibits nNOS with an IC50 of 49 μM. Dimaprit myocytes. dihydrochloride can stimulate gastric acid secretion. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg Epibetulinic acid Ermanin Cat. No.: HY-N0223 Cat. No.: HY-N3848 Epibetulinic acid, isolated from the root bark of Ermanin is a flavonoid isolated from Tanacetum Maytenus cuzcoina and the leaves of Maytenus microphyllum. Ermanin potently inhibits iNOS, chiapensis, exhibits potent inhibitory effects on COX-2 activities, and inhibits platelet NO and prostaglandin E2 (PGE2) production in aggregation. Ermanin has anti-inflammatory, mouse macrophages (RAW 264.7) stimulated with anti-tuberculous and anti-viral/bacterial bacterial endotoxin with IC50s of 0.7 and 0.6… properties.
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