Kasugamycin Hydrochloride PRODUCT DATA SHEET Issue Date 01/06/2020

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Kasugamycin hydrochloride PRODUCT DATA SHEET issue date 01/06/2020 Product Name: Kasugamycin hydrochloride Product Number: K005 CAS Number: 19408-46-9 Molecular Formula: C14H25N3O9 · HCl Molecular Weight: 415.82 Form: Powder Appearance: White crystalline powder Solubility: is freely soluble in aqueous solution. Source: Streptomyces kasugaensis Melting Point: 203 °C Storage Conditions: 28 °C Description: Kasugamycin hydrochloride is a salt form a Kasugamycin, is a broad- spectrum antibacterial and antifungal aminoglycoside originally isolated in 1965 from Streptomyces kasugaensis found near the Kasuga shrine in Japan. This natural product used against yeast and pathogenic fungi such as M. grisea. Kasugamycin is freely soluble in aqueous solution. Mechanism of Action: Like many of the known natural antibiotics, kasugamycin inhibits proliferation of bacteria by tampering with their ability to make new proteins, the ribosome being the major target. Kasugamycin inhibits protein synthesis at the step of translation initiation by direct competition with initiator transfer RNA. Plant Biology In rice models, kasugamycin is used to prevent and cure M. grisea mycelia Applications formation with <20 µg/mL. In addition, kasugamycin has shown to suppress a number of plant parasitic infections such as leaf spot and apple scab. Kasugamycin is preferentially used over other antifungals due to its lower phytoxicity and toxicity to animals. References: Masukawa H, Tanaka N, Umezawa H. (1968) Inhibition by kasugamycin of protein synthesis in Piricularia oryzae. J Antibiot (Tokyo). 21(1):73-74 PMID 4970570 Ochi K et al (2008 ) Inactivation of KsgA, a 16S rRNA Methyltransferase, causes vigorous emergence of mutants with high-Level Kasugamycin resistance. Antimicrob. Agents. Chemother. 53 (1): 193-201 Surkov S et al (2010) Translation initiation region dependcey fo translation initiation in Escherichia coli by IF1 and kasugamycin. FEBS J. 277 (11):2428- 2439 If you need any help, contact us: [email protected]. Find more information on: www.toku-e.com/.

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Kasugamycin Crops Identification of Petitioned Substance
United States Department of Agriculture Agricultural Marketing Service | National Organic Program Document Cover Sheet https://www.ams.usda.gov/rules-regulations/organic/national-list/petitioned Document Type: ☐ National List Petition or Petition Update A petition is a request to amend the USDA National Organic Program’s National List of Allowed and Prohibited Substances (National List). Any person may submit a petition to have a substance evaluated by the National Organic Standards Board (7 CFR 205.607(a)). Guidelines for submitting a petition are available in the NOP Handbook as NOP 3011, National List Petition Guidelines. Petitions are posted for the public on the NOP website for Petitioned Substances. ☒ Technical Report A technical report is developed in response to a petition to amend the National List. Reports are also developed to assist in the review of substances that are already on the National List. Technical reports are completed by third-party contractors and are available to the public on the NOP website for Petitioned Substances. Contractor names and dates completed are available in the report. Kasugamycin Crops Identification of Petitioned Substance 1 Chemical Names: Other Name: 2 Kasugamycin Kasugamycin hydrochloride hydrate 3 2-amino-2-[(2R,3S,5S,6R)-5-amino-2-methyl-6- Kasugamycin monohydrochloride 4 [(2R,3S,5S,6S)-2,3,4,5,6- 5 pentahydroxycyclohexyl]oxyoxan-3- Trade Names: 6 yl]iminoacetic acid (IUPAC name) Kasumin 2L, Kasumin 4L 7 8 3-O-[2-amino-4-[(carboxyiminomethyl)amino]- CAS Numbers: 9 2,3,4,6-tetradeoxy-a-D-arabino-hexopyranosyl]- Kasugamycin (6980-18-3) 10 D-chiro-inositol Kasugamycin monohydrochloride (19408-46-9) 11 12 Other Codes: 13 Kasugamycin Pub Chem CID 65174 14 15 16 Summary of Petitioned Use 17 18 The National Organic Program (NOP) was petitioned to add kasugamycin as an allowed synthetic to the 19 synthetic substances National List at 7 CFR §205.601.
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