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Associate Award 2: Year 4, Quarter 1 Progress Report Inform Asia: USAID’s Health Research Program Associate Award 2: Year 4, Quarter 1 Progress Report Submission Date: Resubmitted: February 28, 2019 Cooperative Agreement Number: AID-486-LA-15-00002 Activity Start Date and End Date: September 24, 2015 to September 30, 2020 Agreement Officer’s Representative Name: RAO Name: Submitted by: This document was produced for review by the United States Agency for International Development (USAID) Regional Development Mission for Asia. It was prepared by RTI International. DISCLAIMER: The author's views expressed in this publication do not necessarily reflect the views of the United States Agency for International Development or the United States Government. This document is intended to comply with Section 508 Standard of the Federal Acquisition Regulation. If you have any difficulties accessing this document, please contact [email protected]. Table of Contents List of Figures ..........................................................................................................................................iii List of Tables ...........................................................................................................................................iii List of Acronyms and Abbreviations ....................................................................................................... iv 1. Program Overview/Summary ........................................................................................................... 1 2. Activity Implementation Progress ..................................................................................................... 5 3. Management and Administrative Issues ........................................................................................ 30 4. Planned Activities for Next Quarter, Including Upcoming Events and Travel ................................ 32 Annex 1: Y4 Milestones, Deliverables, Targets, and Timeline Against Results in Q1, Y4 ................... 34 Annex 2: Monitoring, Evaluation, and Learning Indicator Reports (as of Q1, Y4) ................................ 41 Annex 3: Financial Report (as of December 31, 2018) ......................................................................... 47 Annex 4: Timeliness of Malaria Reporting – Indicator 1.3 .................................................................... 48 Annex 5: Malaria cases with complete information – Indicator 1.4 ....................................................... 52 Annex 6: Drug Efficacy Evaluation ........................................................................................................ 55 Inform Asia: USAID’s Health Research Program; Associate Award 2: Year 4, Quarter 1, Oct 1–Dec 31, 2018 ii List of Figures Figure 1. Associate Award 2 Results Framework, Y4 ............................................................................ 1 Figure 2. Current vs. proposed workflow to improve the information from the weekly R506 to the MIS.......................................................................................................................................... 9 Figure 3. Work flow for 1-3-7 strategy in Vientiane province ................................................................ 13 Figure 4. Flowchart for malaria case follow-up in Thailand .................................................................. 14 Figure 5. Foci reversion cohort analysis and Kaplan-Meier survival curve .......................................... 21 Figure 6. Inform Asia’s organogram, Y4 Q1 ......................................................................................... 31 Figure 7. Proportion of reporting units reporting on time, by month and organization type .................. 49 Figure 8. Percentage of reporting units that submitted data to the MIS according to the recommended timeline in Thailand ............................................................................................. 50 Figure 9. Percentage of Lao PDR reporting units that submitted a monthly report according to the recommended timeline ......................................................................................................... 51 Figure 10. Number of cases by reporting unit type ............................................................................... 52 Figure 11. Treatment information completeness by reporting unit type ............................................... 53 Figure 12. NTG compliance by reporting unit type ............................................................................... 54 Figure 13. Drug efficacy evaluation – NTG treatment compliance ....................................................... 55 Figure 14. Drug efficacy evaluation – complete follow-up rate ............................................................. 56 Figure 15. Drug efficacy evaluation – Follow-up and parasite recurrent rates ..................................... 56 Figure 16. Drug efficacy evaluation – Parasite recurrence for patients treated with NTG.................... 57 Figure 17. Drug efficacy evaluation – DHA-PIP .................................................................................... 57 Figure 18. Drug efficacy evaluation – CQ + PQ .................................................................................... 58 List of Tables Table 1. Summary of progress toward achieving results achieved during Q1, Y4 ................................. 2 Table 2. Summary of malaria activities and their sources of funding ................................................... 11 Table 3. Current list of tools for data collection, monitoring, and supervision for malaria elimination in Lao PDR ............................................................................................................... 12 Table 4. MIS readiness assessment team member roles and responsibilities ..................................... 16 Table 5. SI and knowledge products under development in Q1, Y4 .................................................... 25 Table 6. STTA inputs named in the Year 4 work plan and their contribution by the end of Q1 ............ 31 Table 7. International travel proposed for Q2, Y4 ................................................................................. 32 Table 8. Number, proportion, and mean number of malaria cases reported in the MIS by organization type, Q1, Y4 ........................................................................................................... 48 Table 9. Treatment completeness by reporting unit, Q1, Y4 ................................................................ 53 Table 10. Facility with the greatest number of non-compliant NTG treatment cases ........................... 54 Inform Asia: USAID’s Health Research Program; Associate Award 2: Year 4, Quarter 1, Oct 1–Dec 31, 2018 iii List of Acronyms and Abbreviations ABER Annual Blood Examination Rate AFRIMS Armed Forces Research Institute of Medicines AJTMH American Journal of Tropical Medicine and Hygiene AOR Adjusted Odds Ratio AS Artesunate ASTMH American Society of Tropical Medicine and Hygiene BIOPHICS Center of Excellence for Biomedical and Public Health Informatics BMGF Bill & Melinda Gates Foundation BMP Border Malaria Post BOE Bureau of Epidemiology BVBD Bureau of Vector Borne Diseases CBA Cost-Benefit Analysis CHAI Clinton Health Access Initiative CMPE Centre for Malaria, Parasitology and Entomology COP Chief of Party CQ Chloroquine DAMN District Anti-Malaria Nucleus DDC Department of Disease Control DHA-PIP Dihydroartemisinin-Piperaquine DHIS2 District Health Information System 2 DHO District Health Office EOC Emergency Operation Center FY Fiscal Year GF RAI2E Global Fund to Fight AIDS, Tuberculosis and Malaria, Regional Artemisinin-resistance Initiative 2–Elimination GIS Geographic Information System HIS Hospital Information System HPH Health Promotion Hospital iDES integrated drug efficacy surveillance IR Intermediate Result IRS Indoor Residual Spraying IT Information Technology JITMM Joint International Tropical Medicine Meeting LAO Local Administrative Organization LLIN Long-Lasting Insecticidal Net LOE Level of Effort MC Malaria Clinic MEL Monitoring, Evaluation, and Learning mHealth Mobile Healthcare MIS Malaria Information System MOA Memorandum of Agreement MOH Ministry of Health MOPH Ministry of Public Health MORU Mahidol-Oxford Research Unit MOU Memorandum of Understanding MP Malaria Post MQ Mefloquine N/A Not Applicable NGO Nongovernmental Organization NHSO National Health Security Office NMES National Malaria Elimination Strategy NTG National Treatment Guidelines ODPC Office of Disease Prevention and Control PAMS Provincial Anti-Malaria Station Lao PDR Lao People’s Democratic Republic Pf Plasmodium Falciparum PHD Provincial Health Department PHO Provincial Health Office PMI President’s Malaria Initiative PQ Primaquine Pv Plasmodium vivax Q Quarter RDMA Regional Development Mission for Asia RDT Rapid Diagnostic Test SCD Special Case Detection SI Strategic Information SOP Standard Operating Procedures SOW Scope of Work Inform Asia: USAID’s Health Research Program; Associate Award 2: Year 4, Quarter 1, Oct 1–Dec 31, 2018 v STTA Short-Term Technical Assistance TA Technical Assistance TBD To Be Determined UCSF University of California, San Francisco UNOPS United Nations Office for Project Services USAID United States Agency for International Development USG US Government VBDU Vector Borne Disease Unit VMW Village Malaria Workers WHO World Health Organization Y Year 1. Program Overview/Summary Inform Asia:
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