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Front Matter ANTICANCER RESEARCH International Journal of Cancer Research and Treatment ISSN: 0250-7005 Volume 39, Number 1, January 2019 Contents Reviews Evolution of Cancer Progression in the Context of Darwinism. L. LACINA, M. ČOMA, B. DVOŘÁNKOVÁ, O. KODET, N. MELEGOVÁ, P. GÁL, K. SMETANA JR (Prague; Vestec, Czech Republic; Košice; Bratislava, Slovak Republic) ................................................................................................................................................................ 1 An Update on the Current Role of High Resolution Anoscopy in Patients With Anal Dysplasia. A. GUDUR, D. SHANMUGANANDAMURTHY, Z. SZEP, J.L. POGGIO (Philadelphia, PA, USA) ............................................... 17 Anticoagulant Therapy for Disseminated Intravascular Coagulation After Gastrointestinal Surgery. D. HASHIMOTO, T. OKAWA, R. MARUYAMA, F. MATSUMURA, Y. SHIBATA, H. KOHROGI (Kumamoto; Omuta, Japan) .................................................................................................................................................................... 25 MicroRNA Expression in the Progression and Aggressiveness of Papillary Thyroid Carcinoma. A. ZEMBSKA, A. JAWIARCZYK-PRZYBYŁOWSKA, B. WOJTCZAK, M. BOLANOWSKI (Wroclaw, Poland) ..................... 33 Bioactive Sphingolipids as Biomarkers Predictive of Disease Severity and Treatment Response in Cancer: Current Status and Translational Challenges. M. SEDIĆ, P. GRBČIĆ, S. KRALJEVIĆ PAVELIĆ (Rijeka, Croatia) ........ 41 Experimental Studies Combination of Biochanin A and Temozolomide Impairs Tumor Growth by Modulating Cell Metabolism in Glioblastoma Multiforme. V. DESAI, A. JAIN, H. SHAGHAGHI, R. SUMMER, J.C.K. LAI, A. BHUSHAN (Philadelphia, PA; Pocatello, ID, USA) .......................................................................................................................... 57 A Single Nucleotide Polymorphism in SLC7A5 Was Associated With Clinical Response in Multiple Myeloma Patients. M.J. POI, J. LI, J.A. JOHNSON, Y.K. CHO, D.W. SBOROV, M.A. PHELPS, C.C. HOFMEISTER (Columbus, OH; Salt Lake City, UT; Atlanta, GA, USA) .............................................................................................. 67 Contents continued on the back cover ISSN (print): 0250-7005 ISSN (online): 1791-7530 Editorial Board Editorial Office: International Institute of Anticancer Research, 1st km Kapandritiou-Kalamou Rd., Kapandriti, P.O. Box 22, Attiki 19014, P. A. ABRAHAMSSON , Malm , Sweden S. D. KOTTARIDIS, Athens, Greece ö Greece. Tel / Fax: +30-22950-53389. B. B. AGGARWAL, Houston, TX, USA G. R. F. KRUEGER, K ln, Germany ö U.S. Branch: Anticancer Research USA, Inc., 111 Bay Avenue, T. AKIMOTO, Kashiwa, Chiba, Japan Pat M. KUMAR, Manchester, UK Highlands, NJ 07732, USA. P. Z. ANASTASIADIS, Jacksonville, FL, USA Shant KUMAR, Manchester, UK E-mails: Editorial Office: [email protected] A. ARGIRIS, San Antonio, TX, USA O. D. LAERUM, Bergen, Norway Managing Editor: [email protected] J. P. ARMAND, Toulouse, France F. J. LEJEUNE, Lausanne, Switzerland ANTICANCER RESEARCH supports: (a) the establishment and the V. I. AVRAMIS, Los Angeles, CA, USA S. LINDER, Link ping, Sweden ö activities of the INTERNATIONAL INSTITUTE OF ANTICANCER D.-T. BAU, Taichung, Taiwan, ROC L. F. LIU, Piscataway, NJ, USA RESEARCH (IIAR; Kapandriti, Attiki, Greece); and (b) the organization G. BAUER, Freiburg, Germany D. M. LOPEZ, Miami, FL, USA of the International Conferences of Anticancer Research. The IIAR is a member of UICC. For more information about ANTICANCER E. E. BAULIEU, Le Kremlin-Bicetre, France E. LUNDGREN, Um ea°, Sweden E. J. BENZ , Jr., Boston, MA, USA Y. MAEHARA, Fukuoka, Japan RESEARCH, IIAR and the Conferences, please visit the IIAR website: J. BERGH, Stockholm, Sweden J. MAHER , London, UK www.iiar-anticancer.org F. T. BOSMAN, Lausanne, Switzerland J. MARESCAUX, Strasbourg, France Publication Data: ANTICANCER RESEARCH (AR) is published bimonthly from January 1981 to December 2008 and monthly from M. BOUVET, La Jolla, CA, USA J. MARK, Sk vde, Sweden ö January 2009. Each annual volume comprises 12 issues. Annual Author S. S. MARTIN, Baltimore, MD, USA J. BOYD, Miami, FL, USA and Subject Indices are included in the last issue of each volume. G. BROICH, Monza, Italy S. MITRA, Houston, TX, USA ANTICANCER RESEARCH Vol. 24 (2004) and onwards appears online . S. BRULAND, Oslo, Norway S. MIYAMOTO, Fukuoka, Japan Ø with Stanford University HighWire Press from April 2009. J. M. BUATTI, Iowa City, IA, USA S. MONCADA, Manchester, UK Copyright: On publication of a manuscript in AR, which is a M. M. BURGER, Basel, Switzerland M. MUELLER, Villingen-Schwenningen, copyrighted publication, the legal ownership of all published parts of M. CARBONE, Honolulu, HI, USA Germany the paper passes from the Author(s) to the Journal. C. CARLBERG, Kuopio, Finland F. M. MUGGIA, New York, NY, USA Annual Subscription Rates 2018 per volume: Institutional subscription J. CARLSSON, Uppsala, Sweden M. NAMIKI, Kanazawa, Ishikawa, Japan US$ 1,898.00 (online) or US$ 2,277.00 (print & online). Personal A. F. CHAMBERS, London, ON, Canada R. NARAYANAN, Boca Raton, FL, USA subscription US$ 897.00 (online) or US$ 1,277.00 (print & online). P. CHANDRA, Frankfurt am Main, Germany K. NILSSON, Uppsala, Sweden Prices include rapid delivery and insurance. The complete previous L. CHENG, Indianapolis, IN, USA S. PATHAK, Houston, TX, USA volumes of Anticancer Research (Vol. 1-37, 1981-2017) are available at 50% discount on the above rates. J.-G. CHUNG , Taichung, Taiwan, ROC J.L. PERSSON, Malm , Sweden ö Subscription Orders: Orders can be placed at agencies, bookstores, or R. CLARKE, Washington, DC, USA G. J. PILKINGTON, Portsmouth, UK directly with the Publisher. (e-mail: [email protected]) E. DE CLERCQ, Leuven, Belgium C. D. PLATSOUCAS, Norfolk, VA, USA Advertising: All correspondence and rate requests should be W. DEN OTTER, Amsterdam , The Netherlands A. POLLIACK, Jerusalem, Israel addressed to the Editorial Office. E. P. DIAMANDIS, Toronto, ON, Canada D. RADES , L beck, Germany ü Book Reviews: Recently published books and journals should be sent to G. TH. DIAMANDOPOULOS, Boston, MA, USA M. RIGAUD, Limoges, France the Editorial Office. Reviews will be published within 2-4 months. L. EGEVAD , Stockholm, Sweden U. RINGBORG, Stockholm, Sweden Articles in ANTICANCER RESEARCH are regularly indexed in all D. W. FELSHER , Stanford, CA, USA M. ROSELLI, Rome, Italy bibliographic services, including Current Contents (Life Sciences), Science J. A. 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