Public CURRICULUM VITAE Name David Paul Cracroft RICE

Date of birth 06-11-1964

ORCID ID https://orcid.org/0000-0001-9301-3078

Current position Professor of Orthodontics & Head of Department, Oral & Maxillofacial Diseases, University of Helsinki, Finland 2007- Consultant Orthodontist, Oral & Maxillofacial Diseases, Helsinki University Hospital, Finland 2007-

Education and training BDS Royal Hospital Medical College, London University Dentistry 1987 FDS Royal College of Surgeons of England Advanced 1990 Dentistry MSc Guy’s Hospital Medical School, University of London Craniofacial 1993 growth MOrth Royal College of Surgeons of England Orthodontics 1994 PhD University of Helsinki, Finland Developmental 1999 Thesis: Molecular mechanisms in calvarial bone and suture Biology development FDSOrth Royal College of Surgeons, Intercollegiate specialty Orthodontics 2000 examination PGCAP Postgraduate Certificate in Academic Practice, KILT, Pedagogy 2005 University of London (Registered practitioner, Higher Education Academy, 30873)

Previous professional appointments General Dentist Windsor, UK (18 months) 01.1988- 06.1989 House Office Dept. of Oral and Maxillofacial Surgery Kingston 07.1989- Hospital, University of London UK (6 months) 01.1990 House Office Norman Rowe Maxillofacial Unit, Queen Mary's 02.1990- University Hospital, , UK (6 months) 07.1990 Senior House Dept. Oral and Maxillofacial Surgery, Poole General 08.1990- Officer Hospital, UK (13 months) 09.1991 Registrar & Dept. Orthodontics, Guy's Hospital & Queen Mary’s 10.1991- Masters Student Hospital, London University, UK (36 months) 09.1994 Lecturer, Doctoral Dept Orthodontics, Institute of Dentistry & 10.1994- Student & Developmental Biology Program, Institute of 07.2000 Research Fellow Biotechnology, University of Helsinki, Finland (61 months) Postdoctoral Institute of Biotechnology, University of Helsinki, Finland 11.1999- Research Fellow, (24 months) 10.2001 Senior Lecturer & Depts of Orthodontics & Craniofacial Development, 10.2001- Honorary King’s College & Guy’s Hospital, University of London, 06.2007 Consultant (MRC UK (68 months) Sen Clinician Scientist 2001- 2005) Hon Visiting Hon Visiting Professor, King’s College & Guy’s Hospital, 2008-2012 Professor, University of London, UK

Scientific awards and honours WJB Houston Research Award, European Orthodontic Society 1994 Travelling Research Fellowship (One year), Wellcome Trust 1994 WJB Houston Research Scholarship, European Orthodontic Society 1995 Sulo Toivanen Best PhD Thesis Award, Finnish Cell and Developmental Biology Society 1999 Best Poster Award, European Symposium on Calcified Tissues 2000 Senior Clinician Scientist Award, Medical Research Council, UK 2001 Best Poster Award, Medical Research Society Fellows Meeting 2002 Honorary Fellowship in Dental Surgery, Royal College of Surgeons of 2007 I was the first dentist to win the prestigious Clinician Scientist Award from the Medical Research Council UK. This was won after open competition with the entire biomedical community in the United Kingdom. Also, I was the first foreigner to be appointed as professor at the medical faculty, University of Helsinki.

Scientific/education expert positions Editorial Editor-in-Chief: European Journal of Orthodontics 2010-2017, 2017-2024 Associate Editor: Frontiers in Craniofacial Biology 2010- Guest Editor: PLOS Genetics 2016-2017

External reviewer for promotion, appointment and award for: Dept of Plastic Surgery, Stanford University, USA 2005; Dept of Orthopaedic Surgery, University of Leuven, Belgium 2006; Dept of Surgery, Los Angeles Children’s Hospital, USA 2007; School of Dentistry, King’s College London, UK 2007; School of Dentistry, University of Michigan, Ann Arbour, USA 2008; School of Dentistry, Berne University, Switzerland 2008 School of Dentistry, King’s College London, UK 2010 School of Dentistry, Seoul National University, Republic of Korea 2013 Faculty of Medicine, Dentistry and Health, University of , UK 2013 Faculty of Medicine, University of Toronto, Canada 2014 Australian Orthodontic Society, Begg award 2014 School of Dentistry, King’s College London, UK 2016 Faculty of Medicine, University of Oulu, Finland 2016 Karolinska Insitutet, Sweden, 2016

Internal reviewer for promotion and appointment for: Panel member of review of promotion of Timo Otonkoski to Professor, Faculty of Medicine, Helsinki 2011-2012 Docent assessor, Satu Kuure PhD, Developmental Genetics 2012 Docent assessor, Minna Pekkinen PhD, Genetics 2019

Professorship appointments committee 2014 Professorship in Oral Pathology, Faculty of Medicine, University of Helsinki. Appointed Tuula Salo (chair of committee) 2016-2017 Professorship in Microscopic Imaging, Faculty of Medicine, University of Helsinki. Appointed XXX 2018 Professorship in Oral and Maxillofacial Surgery, Faculty of Medicine, University of Helsinki. Appointed XXX

External research grant reviewer for: Biotechnology and Biological Sciences Research Council UK; MRC The Netherlands; European Orthodontic Society; Flanders Research Foundation, Belgium; MRC UK; MRC Singapore, The Wellcome Trust, University of Leuven Belgium, University of Eastern Finland

External independent evaluator of research: RED10 assessment of University of Göteborg, Sweden, 2010, Panel member

Research funding agency, membership Swedish Research Council, Panel member, Medical MH-A1 2013-2019 Swedish Research Council, Panel Vice chairperson, Medical MH-A1 2016

External independent evaluator of education program: Network of Erasmus Based European Orthodontic Postgraduate Programmes (NEBEOP) expert independent assessor, including site visit, University of Zurich, Switzerland 2015; 2nd University Naples, Italy, 2016

Doctoral thesis supervision PhD supervisor: University of London, UK Elaine Connor (2005) University of London, UK Eva Lana (2008) University of Helsinki, Finland Lotta Veistinen (2015) University of Helsinki, Finland Maria Sanz Navarro (2018)

Both my UK PhD students in the UK have won the first prize in the King’s College Dental Institute postgraduate research days - an open competition of approximately 32 contestants. Current doctoral student supervision 2019 Maria Sanz Navarro, Rakibul Md Hasan, Wael Awadh, Marjut Evälahti

PhD examiner: University of Adelaide, Australia Craig Dreyer, 2002 University of London, UK Jo Barnard, 2005 University of , UK Michael Risley, 2006 University of Queensland, Australia Anna Coussens, 2007 University of Manchester, UK Helen Thomason, 2007 University of Göteborg, Sweden Forugh Variri Sani, 2008 University of London, UK Kingyin Lee, 2008 University of Copenhagen, Denmark Liselotte Sonnesen, 2008/9 (DOdont) Karolinska Institutet, Sweden Marie Pegelow, 2012 University of Oslo, Norway Tanya Franzen, 2015 University of London, UK Kshemendra Senarath-Yapa, 2016 University of London, UK Hazha Star, 2016 University of Bern, Switzerland Younes El Fersioui, 2017 University of Göteborg, Sweden Pamela Uribe 2017 University of London, UK Anahid Ahmadi Birjandi, 2018 Karolinska Institutet, Sweden Konstantinos Parikakis, 2018

PhD reviewer: University of Helsinki, Finland Nina Trokovic, 2005 University of Oulu, Finland Riikka Ylönen, 2005 University of Helsinki, Finland Elina Järvinen, 2008 University of Oulu, Finland Marja Riitta Perkiömäki, 2008 University of Helsinki, Finland Roxana Ola, 2012 University of Helsinki, Finland Jonna Saarimäki-Vire, 2012 University of Helsinki, Finland Maria Jussila, 2014

Masters examiner/supervisor: University of London, UK Susan Amin, 2004 University of London, UK Mohi Ahmed, 2005 University of London, UK Joanna Andryszkiewicz, 2005 University of London, UK Bartosz Balczerski, 2006 University of London, UK Puangwan Lapthanasupkul, 2006 University of London, UK Susan Parekh, 2006 University of Helsinki, Finland Anastasia Immonen, 2010 University of Helsinki, Finland Nina Perälä, 2016 University of Helsinki, Finland Anniina Pirttiniemi, 2017 University of Helsinki, Finland Jari Hämäläinen, 2009 University of Helsinki, Finland Laura Nieminen, 2010 University of Helsinki, Finland Mari Vehviläinen, 2011 University of Helsinki, Finland Jetta Kelppe, 2011 University of Helsinki, Finland Carina Lund, 2012 University of Helsinki, Finland Henriikka Tuovinen, 2012 University of Helsinki, Finland Minna Hokkanen, 2012 University of Helsinki, Finland Eeva Mikkola Hokkanen, 2013 University of Helsinki, Finland Ulrika Sunden, 2013 University of Helsinki, Finland Jenny Lindström, 2013 University of Helsinki, Finland Viivi Mattila, 2014 University of Helsinki, Finland Laura Nieminen, 2015 University of Helsinki, Finland Vatteri Arvaja, 2015 University of Helsinki, Finland Anna Julkunen, 2015 University of Helsinki, Finland Lauri Mäkinen, 2015 University of Helsinki, Finland Laura Maidell-Hjort, 2015 University of Helsinki, Finland Kaisa Kekki, 2015 University of Helsinki, Finland Iina J Helenius, 2016 University of Helsinki, Finland Juha Kemppainen, 2016 University of Helsinki, Finland Sampo Seppäläinen, 2016 University of Helsinki, Finland Eveliina Leppänen, 2017 University of Helsinki, Finland Tuomas Hämmäläinen, 2017 University of Helsinki, Finland Anna Tuokkala, 2017 University of Helsinki, Finland Marjukka Tervala, 2017 University of Helsinki, Finland Mikko Lahtinen, 2017 University of Helsinki, Finland Rebecca Ikonen, 2018 University of Helsinki, Finland Sampsa Knuutila, 2018 University of Helsinki, Finland Oona Sarmalinna, 2018 University of Helsinki, Finland Marjo Tapola, 2018 University of Helsinki, Finland Kristiina Linnupöld, 2018 University of Helsinki, Finland Linda Päivinen, 2018 University of Helsinki, Finland Mia Huthanen, 2018 University of Bern, Switzerland Franziska Ducommun-Gugger, 2018 University of Bern, Switzerland Meret Gebistorf, 2018 University of Bern, Switzerland Jean-Baptiste Kopp, 2018 University of Bern, Switzerland Marco Seiler, 2018

Current Masters thesis supervision, 2019 Roosa Mäkitalo, potilastyö, Terhi (+ David) Pinja Saario, potilastyö, Terhi (+ David) Pipsa Pousi, kirjallisuuskatsaus or potilastyö, Lotta (+ David) Ida Jokinen, potilastyö/kirjallisuuskatsaus, Anu (+ David) Satu Suvijärvi, Kirjallisuuskatsaus + potilas kokemus, David (Tuula/Anu) Aydil Ainetdin, Kraniofakiaalisen kehityksen perustutkimus, Pekka + David Risto Oudman, Kraniofakiaalisen kehityksen perustutkimus, David Aini Hyytiäinen, TLO, Kraniofakiaalisen kehityksen perustutkimus, David Julia Ranta, TLO, Kraniofakiaalisen kehityksen perustutkimus, David

Supervision orthodontics specialisation students Approx 27 students graduated 2008-2018

Research grants: Wellcome Trust & Sigrid Juselius - Travelling Research Fellowship 1994 €47850 European Orthodontic Society - Houston Research Scholarship 1995 €43500 Medical Research Council - Senior Clinician Scientist Fellowship 2001-2007 €938762 Smaller grants from Royal Society, Finnish Dental Society, CIMO €36262 University of Helsinki research fund 2006 €120000 Juselius Foundation 2007-2013 €309000 Biocentrum Helsinki, other university funds 2007 €180000 Academy of Finland 2009-2012 €280000 Academy of Finland 2013-2017 €448682 Yliopistotasoisen Terveyden Tutkimus 2014 €25500 Yliopistotasoisen Terveyden Tutkimus 2015-2017 €76500 Yliopistotasoisen Terveyden Tutkimus 2019-2020 €50000 €2566056

Scientific/education positions of trust and administration – Local, national 2010-2012 Lead Scientist Dental Research Community, External Evaluation, Helsinki University 2014-2018 Director, Finnish Doctoral School in Oral Sciences, Helsinki Branch FINDOS-Helsinki 2015-2019 Director, Finnish Doctoral School in Oral Sciences, National organisation (FINDOS) 2007-2014 Dental Education Committee (University of Helsinki) 2007- Local Education Integration Committee (University of Helsinki-Helsinki City Health Services- Helsinki University Hospital) 2012-2018 HUS Regional Health Support Service Committee (Diagnostisten palveluiden liikelaitosten johtokunta), Faculty of Medicine representative (reserve) 2010-2014 Institute of Dentistry, University of Helsinki, board member (reserve) 2014- Faculty of Medicine Board, University of Helsinki, member (reserve) 2014- MD-PhD program (TLO), Faculty of Medicine, University of Helsinki, Board member 2014- Doctoral School in Health Sciences Board, University of Helsinki, expert member 2015 – Finnish Dental Society Apollonia, Charitable Foundation, board member 2010- Finnish Cell and Developmental Biology Society Board member

Scientific Activity My research is aimed at understanding the molecular basis of morphological change during craniofacial development. My lab primarily focuses on trying to understand how the mammalian calvarial bones and sutures develop. In addition, we also study the developing palate and tooth. Understanding the developmental processes underpinning these systems also gives us a greater insight into the molecular pathogenesis of diseases that result when normal development is disrupted, notably cleft palate and craniosynostosis (premature fusion of the calvarial sutures). These are the two most common craniofacial anomalies with affected individuals and their families suffering profound effects that require extensive multidisciplinary treatment over many years. Practically speaking this work will help clinicians and patients understand their conditions, particularly regarding the most common questions that people ask in the clinics ‘What has caused the condition?’ ‘Why and when has it occurred?’ ‘Is it likely to occur again?’ and ‘Can it be treated?’ With respect to the last question we are now attempting to develop specific (targeted) treatment methods. Our studies also have wider implications for developmental biology as we investigate the processes of growth factor signaling, tissue-tissue interactions, and mesenchymal condensation formation. My research group is based at the biomedical research institution at the University of Helsinki, where we are linked to the developmental biology programme.

Current research collaborators Prof T Mitsiadis, University of Zurich, Switzerland Dr P Tylzanowski, University of Leuven, Belgium Dr A Vortkamp, University of Essen, Germany Prof T Yamashiro, University of Okayama, Japan Prof S Ruf, University of Giessen, Germany Dr A Heliövaara, National Centre for Craniofacial Anomalies, Helsinki Prof J Jernvall, Institute of Biotechnology, University of Helsinki Dr P Nieminen, Institute of Dentistry, University of Helsinki Prof S Gilbert, Swarthmore College, USA

Public dissemination of science 2004 Press Releases circulated to international news organizations from King’s College Public Relations, MRC UK and Journal of Clinical Investigation Press Agency. Known press coverage includes: ‘Dentistry’, King’s College ‘Comment’ magazine, ‘The British Dental Journal’ and ‘The Probe’. 2008 National TV Channel 1, interview on ‘Good morning Finland’ 2010 Medical Faculty Campus Day, University of Helsinki, keynote speaker 2016 Video: ‘375 Years of Medical Education’, University of Helsinki.

Teaching, current  2007 onwards: Department Chair and therefore organise and are responsible for undergraduate (250 students) & postgraduate (11 students) education in orthodontics, University of Helsinki. Also, supervision of 4 PhD students (Awadh, Hassan, Evälahti, Sanz Navarro) Also, supervision of MSc students Also, supervision of undergraduate research projects 8 students 2010-  2017 onwards: Orthodontics Specialist Trainee National Core Curriculum and lecture series video (co-organiser)  Registered practitioner of the Higher Education Academy (30873)

Teaching, previous and ad hoc Postgraduate PhD supervisor: University of London, UK Elaine Connor (2001-2005) University of London, UK Eva Lana (2004-2008) University of Helsinki, Finland Lotta Veistinen (2015) Both my UK PhD students in the UK have won the first prize in the King’s College Dental Institute postgraduate research days - an open competition of approximately 32 contestants.  2001-2005 Lecturer to currently 23 students PhD students Dept of Craniofacial Development, lecture course in developmental biology  2001-2005 Lecturer on 3 year full-time MSc/MOrth course in Orthodontics, current annual intake 12 students at King’s and 17 students in pan London lecture course, includes clinical supervision, case presentation, lecturing and examining.  2001-2005 Lecturer: National Orthodontics Programme, online initiative by the British Ortho Society  2001-2005 Lecturer: MFDS course, Royal College of Surgeons, London  2004, 2007, 2010, 2013, 2016 Lecturer: Genetics course to postgrad orthodontic trainees, Karolinska Inst, Stockholm  2009-2016 Finnish Dental Society Course, Orthodontics Part I, Helsinki Finland  2010-2012 Lecturer: Genetics course to postgrad orthodontic trainees, University of Oslo, Norway  2008-2009 Lecturer: Nordic Association of Plastic surgeons, HUSUKE, Helsinki, Finland  2011 Lecturer: Joint meeting of Swedish and Finnish Graduate School, Umeå, Sweden Master’s thesis supervision: University of Helsinki, Finland, Orthodontics undergraduate theses approx x4 per year 2007 onwards

Undergraduate  2001-2005 Lecturing and examining, dental students on BDS 2, Oral Biology

Conference and meeting organisation 2009 European Orthodontic Society 84th Annual Congress, Finlandia House~ 1,700 delegates - Chair of Scientific committee, Helsinki, Finland 2009 From birth to adulthood: Multidisciplinary treatment for cleft lip and palate patients. Postgraduate student course, Finlandia House, Helsinki, Finland 2009 The theory and practice of mini-implants in orthodontics. Specialist course, Finlandia House, Helsinki, Finland 2011 Nordic Orthodontic Society Triannual Congress, Chair of Scientific committee, Oulu, Finland 2013 Finnish Society for Cell and Developmental Biology annual scientific, Chair of organising committee, Hyytiälä, Finland 2012 – European Journal of Orthodontics Open sessions – sole organiser Santiago de Compostela, Spain Title ‘Scientific misconduct and fraud in research’, Prof T Eliades, University of Zurich, Prof D Rice 2013 – European Journal of Orthodontics Open sessions – sole organiser Reykjavik, Iceland Title ‘A debate: Randomized controlled trial (RCT): the gold standard or an unobtainable fallacy?‘ Prof L Bondemark, University of Malmö, Prof S Ruf, University of Giessen, Prof D Rice 2014 – European Journal of Orthodontics Open sessions – sole organiser Warsaw, Poland, ‘Accurate reporting of RCTs: Importance & Implementation’ Dr N Pandis, University of Bern, Prof T Eliades, Prof T Peltomäki, Prof D Rice 2015 European Orthodontic Society Distinguished Teacher Course 2015, Dr. Frank Weiland, ‘Evidence Based Clinical Orthodontics – a Contradiction?’, Helsinki, Finland – Joint organiser 2015 – European Journal of Orthodontics Open session – sole organiser Venice, Italy, ‘A debate: Systematic reviews: systematically tell us what we already know’ Prof Y Ren University of Groningen, Dr D Bister University of London, Prof D Rice 2015 FINDOS Spring Festival of Science, Helsinki, Finland 2015 FINDOS Summer School ‘How to design, publish and critically appraise published clinical trials in dentistry’ Nikos Pandis, University of Bern, Switzerland 2016 FINDOS course ‘Genetics in Dentistry’ International speakers: Prof Andrew Wilkie University of Oxford, UK; Dr Marja Laine, ACTA, The Netherlands 2016 – European Journal of Orthodontics Open session – sole organiser Stockholm, Sweden. “When to treat? Are indicators of skeletal maturity useful?” Timo Peltomäki, University of Tampere, Finland; Jasmina Primozic, University of Ljubljana, Slovenia; Raphael Patcas, University of Zurich, Switzerland; Moderator David Rice, Editor EJO 2016 Nordic Young Scientist Conference in Odontology (NYSCO, Tuusula, Finland. Four day residential conference with 100 participants chiefly from Nordic and Baltic countries. Head of stirring committee, Chief organiser. 2017 FINDOS course ‘Treatment of Cleft Lip and Palate’ 2017 – European Journal of Orthodontics Open session, Montreux, Switzerland – sole organiser 3-way quick-fire debate ‘Accelerating tooth movement: more than a placebo effect?’ Drs Martyn Cobourne, King’s College London, UK, Alpdoğan Kantarci, Forsyth Institute, Boston University and Harvard University, Boston, USA and Padhraig Fleming, Queen Mary’s University London, UK.; Moderator David Rice 2018 FINDOS course ‘Common Oral Lesions’ co-organiser 2018 European Journal of Orthodontics Open session, Edinburgh, UK; – sole organiser ‘Measuring treatment benefits: clinician-determined vs patient-reported outcomes?‘ Carlos Flores Mir, University of Alberta and Philip Benson, University of Sheffield, Susan Cunningham, University of London, moderated by David Rice

Most important foreign visits Undergraduate and specialist dental training in the University of London, UK (1982-1994) PhD and postdoc training in University of Helsinki, Finland (1994-2001) Principal Investigator, University of London, UK (2001-2007)

Presentations Selected invited oral presentations - Invited speaker and keynote Nordic Symposium on Craniofacial Growth, Göteborg, Sweden 1994 Gordon Research Conference, Bones and Teeth, NH, USA. 1999 International Association for Dental Research, Chiba, Japan 2001 Nordic Symposium on Craniofacial Growth, Kakskerta, Finland 2002 1st Pan European Federation of IADR, , Wales, UK 2002 British Orthodontic Conference Bournemouth, UK 2003 Anatomical Society Meeting, ‘Making Faces’, St Anne’s College Oxford, UK 2005 Gordon Research Congress, Craniofacial Morphogenesis Ventura, USA 2006 6th International conference on BMPs, Dubrovnik, Croatia 2006 9th Tooth Morphogenesis and Development conference Zurich, Switzerland 2007 Nordic Orthodontic Society Meeting, Reykjavik, Iceland 2008 Finnish Dental Association, Annual Congress, Helsinki 2008 Finnish Bone Society Annual Meeting 2010 Tokyo University School of Dental Medicine – Tokyo, Japan 2011 21st Annual Meeting of Japanese Society for Jaw Deformity, Tokyo, Japan 2011 Nordic Orthodontic Society Meeting, Oulu, Finland 2012 4th Baltic Scientific Conference in Dentistry, Tartu, Estonia 2012 International Finnish Dental Association Symposium, Lahti, Finland 2013 8th Baltic Orthodontic Conference, Tallin, Estonia 2013 Italian Orthodontic Society Annual meeting (SIDO) Rome, Italy 2013 American Association of Orthodontists, Annual Meeting, New Orleans, USA 2014 Nordic Orthodontic Society Meeting, Bergen, Norway 2014 Swedish Center for Rare Orofacial Diseases, Annual Meeting, Göteborg, Sweden 2014 American Association of Orthodontists, Annual Meeting, Keynote, San Francisco, USA 2015 American Association of Orthodontists, Annual Meeting, Keynote, Orlando, USA 2016 European Orthodontic Society, Annual meeting, Keynote, Edinburgh, UK 2018

Recent university department visits as invited speaker 2012 Bern, Zurich, Madrid 2013 Oslo, Ljubljana 2014, 2016, 2018 Bern