GRAP polyclonal antibody Summary: This gene encodes a member of the GRB2/Sem5/Drk family. This member functions as a Catalog Number: PAB6031 cytoplasmic signaling which contains an SH2 domain flanked by two SH3 domains. The SH2 domain Regulatory Status: For research use only (RUO) interacts with ligand-activated receptors for stem cell factor and , and facilitates the formation of Product Description: Goat polyclonal antibody raised a stable complex with the BCR-ABL oncoprotein. This against synthetic peptide of GRAP. protein also associates with the Ras guanine exchange factor SOS1 (son of sevenless homolog 1) Immunogen: A synthetic peptide corresponding to through its N-terminal SH3 domain. [provided by human GRAP. RefSeq]

Sequence: C-GFFPRSYVQPVHL References: 1. The immunoglobulin tail tyrosine motif upgrades Host: Goat memory-type BCRs by incorporating a Grb2-Btk Theoretical MW (kDa): 25.3 signalling module. Engels N, Konig LM, Schulze W, Radtke D, Vanshylla K, Lutz J, Winkler TH, Nitschke L, Reactivity: Human Wienands J Nat Commun. 2014 Nov 21;5:5456. doi: 10.1038/ncomms6456. Applications: ELISA, WB-Ti 2. Grap is a novel SH3-SH2-SH3 adaptor protein that (See our web site product page for detailed applications couples tyrosine kinases to the Ras pathway. Feng GS, information) Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J. J Biol Chem. 1996 May 24;271(21):12129-32. Protocols: See our web site at http://www.abnova.com/support/protocols.asp or product page for detailed protocols

Form: Liquid

Purification: Antigen affinity purification

Concentration: 0.5 mg/mL

Recommend Usage: ELISA (1:32000) Western Blot (0.3-1 ug/mL) The optimal working dilution should be determined by the end user.

Storage Buffer: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)

Storage Instruction: Store at -20°C. Aliquot to avoid repeated freezing and thawing.

Entrez GeneID: 10750

Gene Symbol: GRAP

Gene Alias: MGC64880

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