Washington University School of Medicine Bulletin, 1982-1983

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1982 Washington University School of Medicine bulletin, 1982-1983

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BULLETIN OF WASHINGTON UNIVERSITY (USPS: 078-340) SERIES II, VOLUME LXXX, NUMBER V, JUNE 30, 1982. Published once a month in February, March, April, May, June and September, twice in July, and three times in August by Washington University Lindell and Skinker Boulevards, St. Louis, Mo. 63130. Second-class postage paid at St. Louis, Mo. 1 r-1

j Bulletin of j Washington 1 University St. Louis _3 1 J

J School of Medicine ' 1982/83

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1: You must always be students, learning and unlearning till your life's end, and if . . . you are not prepared to follow your profession in this spirit, I implore you to leave its ranks and betake yourself to some third-class trade. Joseph, Lord Lister (1827-1912) 1

To gather knowledge and to find out new knowledge is the noblest occupation of the physician. To apply that knowledge . . . with sympathy born of understanding, to the relief of human suffering, is his . loveliest occupation. Edward Archibald (1872-1945) r

A medical center is one of the few places—perhaps the only place—where one can see the entire exciting process of the mind of man i J working at its best from start to finish ... the birth of an idea; the establishment of its validity; the placing it in a usable concept; the teaching of it to others; the testing it for practical utility; the careful weighing of the moral and ethical questions that inevitably arise concerning its use; and its discriminating application for the benefit of a particular human being. Walsh McDermott i (1909- ) Journal of Chronic Diseases 16:108, 1963

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^^■oki H^MHMHgHg^ ost of the knowledge and M much of the genius of the V research worker lie behind his selection of what is worth observing. It is a crucial choice, often determining the success or failure of months of work, often differentiating the brilliant discoverer from the . . . plodder. Alan Gregg (1890-1957) The Furtherance of Medical Research [ ■]

It is no forced extrapolation to state that every physician is perforce also a potential clinical I ] investigator when he soundly fulfills his responsibilities for each patient. David Seegal (1899-1972) I 3 The Pharos of Alpha Omega I Alpha 26:7, 1963 V r1 u [ I c One of the most valuable experiences the student may have from a pedagogical point of view is to be required to perform a [ complete physical examination on a patient under the eye of a senior instructor. Yale Kneeland, Jr. c (1901-1970) and Robert F. Loeb (1895-1973) Martini's Principles and Practice c of Physical Diagnosis, Ch. 7

'he needs of children should not be made to wait. John F. Kennedy (1917-1963) Message to Congress on the Nation's Youth, February 14, 1963 ] ] Until homo sapiens becomes more sapient I can see no prospect of his ever avoiding the ] foolishness of war or of his learning that two automobiles cannot occupy the same spot at the same time, especially when they come ] from opposite directions. Broken bones and lacerated wounds are therefore likely to require surgical attention for as long as this would- ] be clairvoyant can see into the future. Evarts A. Graham (1883-1957) Postgraduate Medicine 7:154, 1950

©Medical Center «-Emergency HHii > Public Parking «- Jewish Hospital Barnes Hospital Central Institute For The Deaf Children's Hospital School Of Medicine Medical Care Group School of Dental Medicine Scientific discovery is not a monopoly of the fully matured investigator. It is not unusual for a student to present interesting and promising ideas. Best was a medical student when he was associated with Banting in the experiment which led to the discovery of insulin. Cannon was a medical student when he suggested the use of bismuth for visualization of hollow organs by X ray. It is never too soon to be alert and to question all rules as well as all exceptions. David and Beatrice C. Seegal (1899-1972) (1898- ) The Diplomale 22:125, 1950 3 I 1

Contents

Calendar 4

The Study of Medicine Philosophy and Objectives 6 Curriculum 6 Degree Programs 8 Tutorials, Individualized Programs 10 Grades 10 Rules Governing Promotions 10 Student Research Fellowships 12 Residency Training 12 Postdoctoral Training 12

Admission Entrance Requirements 13 Application Procedure 13 Third-Year Class Transfer Program 14

Financial Information Tuition and Fees 15 Registration and Payment of Tuition, Fees and Other Financial Obligations 15 Estimate of Expenses 15 Financial Assistance 15

Student Life Housing 21 Student Health Service 21 Parking 22 Recreational and Cultural Opportunities 22 Medical Center Alumni Association 23 Continuing Medical Education Program 23 Lectureships and Visiting Professorships 24

Historical Perspective 25

Teaching Facilities The School of Medicine 27 The Medical Center 29 Other Institutions 31 r': Departments of the School Anatomy and Neurobiology 32 i- Anesthesiology 35 Biological Chemistry 37 Genetics 40 Medicine 42

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I " Microbiology and Immunology 55 Neurology and Neurological Surgery 58 Obstetrics and Gynecology 62 Ophthalmology 66 Otolaryngology 68 Pathology 70 Pediatrics 75 Pharmacology 82 Physiology and Biophysics 84 Preventive Medicine and Public Health 86 Psychiatry 90 Radiology 96 Surgery 100

Teaching and Research Divisions Biomedical Computer Laboratory 107 Medical Care Group 109 Neurology 110 Tumor Services 110 Rehabilitation Ill

Graduate Training Biology and Biomedical Sciences 112 Biomedical Engineering 120

Allied Health Professions I Health Administration and Planning 121 Physical Therapy 124 Occupational Therapy 126 Physician Assistant Program 128 Pediatric Nurse Practitioners 129 Radiologic Technology 130

Administration Board of Trustees 131 University 131 School of Medicine 132 Medical Center 132

Officers and Committees of the Faculty 133

Index of Staff Members 151

Schools of the University 161

Map 162

Index 164 Calendar 1982/83 c 1982 t June 7 Monday Academic year begins for the third- I and fourth-year classes. 8. 9 Tuesday, Wednesday National Board Examination, Part I. c 11 1 rula\ Deadline for registration and initial payment of tuition and fees for the third- and fourth-year classes. c July 5 Monday Independence Day observance. c August 23 Monday Academic year begins for the second-year class. 25 Wednesday Orientation, matriculation, and c initial payment of tuition and fees for the first-year class. 27 Friday Deadline for registration and initial payment of tuition and fees for the second-year class. 30 Monday Academic year begins for the first- year class. c September 6 Monday Labor Day holiday. 8, 9 Wednesday. Thursday National Board Examination, Part I. 28, 29 Tuesday, Wednesday National Board Examination, Part II.

November 19 Friday Deadline for payment of the balance of tuition and fees for the J third- and fourth-year classes. 25 Thursday Thanksgiving Day observance. L ] 26 Friday Holiday for first- and second-year classes. J

December 18 Saturday Winter recess begins at 1:00 p.m. J 1983 January 3 Monday Winter recess ends at 8:00 a.m. 7 Friday First semester for the second-year class ends at 5:00 p.m. 10 Monday Second semester for the second- year class begins at 8:00 a.m. 14 Friday Deadline for payment of the balance of tuition and fees due for medical students enrolled in the second-year class. 14 Friday First semester for the first-year class ends at 5:00 p.m. 17 Monday Second semester for the first-year class begins at 8:00 a.m. 21 Friday Deadline for payment of the balance of tuition and fees due for medical students enrolled in the first-year class.

March 18 Friday Spring recess begins at 5:00 p.m. for the first- and second-year classes. 28 Monday Spring recess ends at 8:00 a.m. for the first- and second-year classes.

April 1-3 Friday through Sunday Holiday for the third- and fourth- year classes. 6, 7 Wednesday, Thursday National Board Examination, Part II.

May 13 Friday Academic year ends at 5:00 p.m. for the second-year class. 19 Thursday Academic year ends at 5:00 p.m. for graduating students. 20 Friday Commencement. 21 Saturday Academic year ends for the third- year class. 27 Friday Academic year ends at 5:00 p.m. for the first-year class. 30 Monday Memorial Day holiday.

Clerkship- and Elective-Period Intervals: 1982/83 Period Begins Period Begins I Monday, June 7, 1982 V Monday, November 22, 1982 II Monday, July 19, 1982 VI Monday, January 17, 1983 III Monday, August 30, 1982 VII Monday, February 28, 1983 IV Monday, October 11, 1982 VIII Monday, April 11, 1983

1 t c The curriculum includes a core experience based The Study of upon a sequence of courses that will introduce the student to the broad panorama of medicine. The principles, the methods of investigation, the problems, and the oppor- [ Medicine tunities in each of the major disciplines of medical science PHILOSOPHY AND OBJECTIVES and medical practice are presented in such a way as to Washington University encourages application from help the student select the career best suited to his abilities and gives full consideration to all applicants for admission and goals. c and financial aid without respect to sex, race, handicap, The elective program helps the student to decide color, creed, or national or ethnic origin. University poli- where his major interests lie. It also enables him to benefit cies and programs are nondiscriminatory. The School of from the wide range of specialized knowledge and skills Medicine is committed to recruiting, enrolling, and edu- found in the faculty. As there is not enough time for each c catingan increased number of students from racial minor- student to be introduced to each of today's areas of ity and educationally deprived groups. Masculine pro- specialization, the elective program permits him to select, nouns are used in this book for succinctness only; they are according to his own desires, the areas he wishes to intended to refer to both women and men. explore or to study in depth. c The efforts of the School of Medicine are directed toward providing able students with a stimulating and challenging milieu in which they may acquire a thorough background in scientific medicine, as well as a deep understanding of the meaning of comprehensive medical care. In a field that is developing as rapidly as is medicine, education begun in medical school must serve as the foundation for a lifelong course of learning. As Sir William Osier pointed out some decades ago, a faculty, no matter how talented, can "only instill principles, put the student in the right path, give him methods, teach him how to study, and early to discern between essentials and nonessentials." Today's student is preparing to cope with a changing world, to contribute, in a constructive, considered way, to resolving problems of medicine and of health care. To assist in that preparation, the faculty's mission is to pre- serve the joy of learning and to foster a spirit of discrimi- nation and creativity. It is hoped that each student will achieve this grounding during his years in the School of Medicine.

CURRICULUM The curriculum is the product of prolonged and continuing study, by both faculty and students, of the present and probable future course of medical science and medical practice, and of the ways in which medical education can be kept abreast of this course. It is planned to provide students, who enter medical school with diverse backgrounds and interests and who will undertake a wide variety of careers, with the basic knowledge and skills essential for their further professional development. Modern medical education can no longer hope to be comprehensive; it must be selective. Yet students must develop facility in the understanding and use of several related technical languages: those of anatomy, chemistry, physiology, and clinical medicine. They must share responsibility for the care of the patient. They must also learn how these areas of endeavor are interrelated, how the organization and needs of society influence the methods of providing medical care, and how new knowledge is acquired and old knowledge reevaluated. Table of Required Hours 1982-83 Clinical Clerkship (Third) Year is a 48-week aca- As reported to the Liaison Committee on Medical demic year. Education, representing the Council on Medical Educa- Medicine Clerkship 462 tion of the American Medical Association and the Execu- Neurology/Neurosurgery Clerkship .... 154 tive Council of the Association of American Medical Obstetrics/Gynecology Clerkship 231 Colleges, credit hours for courses are expressed in terms Ophthalmology Clerkship 38.5 of clock hours—the scheduled hours per year of actual Otolaryngology Clerkship 38.5 lecture and laboratory contact between faculty and stu- Pediatrics Clerkship 231 dents. These clock hours are not to be interpreted as Psychiatry Clerkship 231 semester or quarter hours. Surgery Clerkship 462 First-year courses are taught during the 36-week Total clock hours for the year 1,848 academic year. Elective (Fourth) Year is a 48-week academic year. Gross Anatomy 198 Microscopic Anatomy 149 General Biochemistry* 93 Advanced Biochemistry* (93) Medical Genetics 36 To qualify for the doctor of medicine degree at Topics in Clinical Medicine 36 Washington University School of Medicine, fourth-year Medical Microbiology 180 students are required to participate in a minimum of 36 Neural Science 131 weeks of electives (full-time clinical or research courses). General Physiology 198 Two thirds of the minimum required time for the Elective Biomedical Statistics 18 Year must be taken exclusively in residence in the Medicine in Modern Society 36 Washington University School of Medicine elective Total clock hours for the year 1,075 course program. A complete listing of fourth-year elective Second-year courses are taught during the 36-week offerings at Washington University School of Medicine is academic year. available through the Office of the Associate Dean for Introduction to Clinical Medicine 124 Curriculum. Students must take a clinical elective for at Ophthalmology Lectures 9 least six weeks and a research elective for a minimum of 12 Otolaryngology Lectures 9 weeks to receive academic credit. Pathology 303 A maximum of 12 weeks' credit is allowed for full- Pharmacology 180 time elective course work taken at other academic institu- Human Sexuality 19 tions. These may be clinical or research electives. Students Introduction to Clinical Psychiatry 49 desiring credit for work to be done at other institutions Radiology Lectures 36 must petition the Associate Dean for Curriculum and the Surgery Lectures 36 standing subcommittee of the Committee on Academic Pathophysiology Review and Promotions (CARP) 11 for approval of the PP Infectious Diseases 54 plan of study. Absolutely no credit will be granted for PP Rheumatology 9 electives undertaken prior to subcommittee approval. PP Heart 24 Credit may be given for elective work done at any PP Lung 18 point in the standard four-year doctor of medicine degree PP Kidney 22 program so long as participation conforms to current PP Metabolism-Endocrinology 32 elective guidelines and (a) the student is a duly registered, PP Gastroenterology 28 full-time student for a minimum of three years and nine PP Hematology 30 months, including scheduled vacation time, and tuition is PP Oncology 23 paid for four complete academic years; or (b) if transfer- PP Neurophysiology 58 ring into the sophomore class, the student is a duly regis- PP Developmental Biology 58 tered, full-time student for a minimum of two years and Total clock hours for the year 1,121 nine months and tuition is paid for three complete academic years; or (c) if transferring into the junior class, the student is a duly registered, full-time student for a minimum of 22 months and tuition is paid for two complete academic years. Students are encouraged to take lecture-seminar elective courses, but such offerings are optional. Total clock hours for the year 1,386 Total clock hours for four years 5,430 ♦Student's course level determined by Department of Bio- Remuneration for work done while participating in chemistry. electives for credit is prohibited. M.A.-M.D. Program Students who are interested in obtaining a significant research experience during their M.D. training may apply for admission to the M.A.-M.D. Program. This program allows selected students to spend one full year (12-15 months) in a research laboratory. Participating students will be expected to write a thesis at the end of their research time to qualify for receipt of a master's degree in biological science which will be conferred along with the M.D. degree upon graduation. It is expected that the research year will usually take place between the first and second year of the regular medical school curriculum. During the research time, students accepted into this program will qualify for receipt of a graduate stipend currently $5,500. Additional information can be obtained by contacting Mrs. Barbara Fox in the office of MSTP/ Graduate Affairs.

M.D./Ph.D. Medical Scientist Training Program DEGREE PROGRAMS (MSTP) The Washington University School of Medicine The School of Medicine offers a combined offers three programs leading to the M.D. degree: a M.D./Ph.D. program within the Division of Biology and regular four-year program, a five-year program, and a Biomedical Sciences, designed for selected students who combined M.D./Ph.D. program. are interested in a research career and whose undergraduate education has placed major emphasis on science. The Doctor of Medicine, Four-Year Program program permits the student to obtain both the M.D. and By conferring the M.D. degree, the University certi- the Ph.D. degree, usually within six years of study. The fies that the student is competent to undertake a career as a doctor of medicine. It certifies further that, in addition major purpose of the program is to train medical scien- to medical knowledge and skills, the graduate possesses tists for careers on clinical and preclinical faculties of schools of medicine. Financial support in the form of qualities of personality—compassion, emotional stabil- ity, and a responsible attitude—essential to an effective stipends (currently $5,500 a year) and tuition remission professional life. will be available for a period of six years to all students A course of medical education for the M.D. degree admitted to the program. Support obtained from ordinarily consists of a minimum of four years of study. National Institutes of Health grants is subject to their Students recommended for the degree doctor of medicine policies governing funding. The program maintains a must be of good moral character, they must have com- population of approximately 80 students. pleted an entire academic course of instruction as matric- The program consists of three segments: 1) the first ulated medical students, they must have passed all two years of the usual medical curriculum, 2) three or required subjects or the equivalent and have received more years of work in the graduate school portion of the satisfactory grades in the work of the full academic program as outlined below, and 3) a final year which is the course, and they must have discharged all current in- usual clinical year of the medical curriculum, individually debtedness to the University. Individuals applying for adjusted to each student's requirements and career goals. licensure must be twenty-one years of age and must have This sequence may be modified to fit individual needs. completed four entire academic years in the study of For example, students may wish to begin their research medicine. after the first year of the regular medical curriculum. At the end of the final academic year, students who Completion of this sequence or its equivalent will satisfy have fulfilled these requirements will be eligible for the requirements for both the Ph.D. and M.D. degree. M.D. degree. While the Medical Scientist Training Program includes all those courses required for the M.D. degree, it Five-Year Program (M.A.-M.D. Program) incorporates a high degree of flexibility for individual In addition to the regular four-year program leading students through a wide range of electives and the large to the M.D. degree, students are permitted to spend one number of thesis programs available at Washington additional year in investigative or research concentration. University. The program must be arranged subject to the approval of The members of the Medical Scientist Training Pro- the Committee on Medical Education. Students who gram Committee are available to students to help them desire a.serious exposure to research may apply for partic- decide in which elective courses and laboratories they will ipation in the M.A.-M.D. Program. participate. I 1 Students begin their training on July 1 of the year Arts and Sciences. These programs provide maximum they enter the School of Medicine. The first two weeks of flexibility for student training and, by providing for inter- the summer will be spent visiting faculty in the various departmental teaching, not only avoid duplication but departments in order to select a laboratory for summer assure that each course is taught by the most qualified research. Students will also spend the summer between faculty, regardless of departmental affiliation. Therefore, their first and second years doing research. There is no course requirements reflect the student's background and obligation that the laboratory selected for summer interests rather than a rigid course sequence. Students research be the same as that ultimately chosen for the may also receive their training by special arrangement in Ph.D. portion of the program. other graduate science departments within the University. A student who passes a qualifying examination in A detailed listing of the various courses available in any of the regularly offered preclinical courses will be the Division of Biology and Biomedical Sciences can be allowed to substitute either advanced course work or found on page as well as in the sections describing the laboratory research in the time made available. In this various departments of the School of Medicine. way students can have the opportunity to do supervised A program of special monthly seminars will be research in free periods during the first two years. In arranged for students during the research years. Con- addition to normal medical school courses, there are ducted by medical scientists of both clinical and preclini- special tutorials for students in the combined degree cal departments of the School of Medicine, these semi- program. nars are aimed at stimulating student interest in clinical The performance of each student will be reviewed medicine and at increasing awareness of major research annually. Students are expected to maintain a high scho- problems in clinical medicine. lastic standard as well as a commitment to research. Usually the following courses are taken in the first Final Year in Clinical Medicine two years. The sixth year is the clinical year of the normal Year 1 medical curriculum. Transition into this year is facilitated First Semester: Gross Anatomy, Biochemistry, Medical Microbiology, Medicine in Modern Society Second Semester: Microscopic Anatomy, Physiol- ogy, Neural Sciences, Medical Genetics, Topics in Clini- cal Medicine, Biomedical Statistics Year 2 Third Semester: Pathology, Pathophysiology, Pharmacology, Introduction to Clinical Medicine Fourth Semester: Pathology, Pathophysiology, Pharmacology, Radiology, Neurology, Surgery, Oph- thalmology, Otolaryngology, Introduction to Clinical Psychiatry, Introduction to Clinical Medicine, Human Sexuality Years, 3,4,5 The student will spend the third, fourth, and fifth years in satisfying the requirements of the Graduate School of Arts and Sciences for the Ph.D. degree. The formal requirements for the Ph.D. degree include (1) completion of course work, (2) successful performance in a qualifying examination, usually at the end of the third year, (3) execution of original research suitable for a dissertation, and (4) defense of the thesis. Students are also required to do a teaching assistantship for a semester in one course. Before beginning the third year, the student will select a faculty advisor under whom he will do his thesis research and the training program or department in which he will obtain his Ph.D. degree. For purposes of graduate training, the Division of Biology and Biomedical Sciences is divided into the fol- 1 lowing programs: Integrative and Cell Biology, Molecu- lar Biology, Neural Sciences, Plant Biology, and Popula- tion Biology. The programs are taught by faculty from all of the preclinical departments of the School of Medicine 1 and from the Department of Biology of the Faculty of Y/ff T

by a special two-week course. Introduction to Clinical official grades have been received, the official transcript, Medicine. The intensive clinical training provided in this in addition to listing courses and grades achieved, gives year is the last formal requirement for the M.D. degree. the grade distribution in each course with the exception of Since one year of the normal medical school curriculum is elective courses. completely elective, the medical scientist will have taken Grades are: the equivalent of that year during the period assigned to H = Honors graduate work. The Ph.D. and M.D. degrees will be HP= High Pass granted simultaneously at the end of the final clinical P - Pass year. F = Fail Doctor of Philosophy Programs DF = Deferred The Washington University Graduate School of INC = Incomplete Arts and Sciences, through the Division of Biology and "Honors" is given for a truly outstanding perfor- Biomcdical Sciences, offers programs in cellular and mance, "High Pass" for very good work, and "Pass" for developmental biology, evolutionary biology and ecol- satisfactory work. "Fail" signifies clearly unsatisfactory ogy, molecular biology, neural sciences, and plant biol- performance. "Deferred" indicates a marginal perfor- ogy leading to the Ph.D. degree. Study is organized on an mance with some deficiency that must be removed, and interdepartmental basis using the faculty of the seven "Incomplete" denotes that course work has not been preclinical departments of the School of Medicine, as well completed. as the Biology Department of the Graduate School. If a departmental coursemaster submits a grade of Additional information and the application for admission "Incomplete," "Deferred," or "Fail" for a medical student may be obtained by writing to: duly enrolled in any medical school course, the coursemaster will include an accompanying statement which Office of Graduate Student Affairs contains the following information: Campus Box 8072 1. Student's name Washington University School of Medicine 2. Course title 660 South Euclid Avenue 3. Inclusive dates of course St. Louis, Missouri 63110 4. Grade 5. Description of extent of academic encumbrance TUTORIALS AND INDIVIDUALIZED 6. Remedial action recommended to remove the PROGRAMS academic encumbrance. The educational program is designed to meet the This type of statement will be submitted to the Office needs of all medical students in an individual and a of the Registrar at the time student grades are reported personalized way. To help students who may be having and prior to the scheduled meetings of the various com- academic difficulty or who may wish to reinforce their mittees on academic review and promotions. studies, individual tutorials are offered. The School's experience is that tutorials enable students to handle PROMOTIONS course work with improved proficiency. Students who are A faculty Committee on Academic Review and found to have difficulties in handling the normal aca- Promotions reviews the records of all students by curricu- demic course load will be asked to take an individualized lum level. program which would require five rather than four years to complete. RULES GOVERNING PROMOTIONS Students must pass all required courses unless GRADES excused from their courses by the responsible depart- In order to assist the student in evaluating his prog- ments. Students must have satisfactorily completed all the ress, he is graded in each course by the faculty. In the required courses for the first two years in order to be clinical and elective years, grades are accompanied by admitted to candidacy for the degree of doctor of medi- detailed descriptive comments characterizing each stu- cine and to proceed to the third year of the curriculum. dent's performance. This type of evaluative data is of Each student's performance will be evaluated period- considerable assistance to the student applying for intern- ically by a faculty Committee on Academic Review and r ship or residency training, since it permits the Assistant Promotions. One such committee (CARP I) is concerned Dean for Postgraduate Training to give each hospital to with the first year, another (CARP II) with the second which the student has applied a meaningful, comprehen- year, and a third (CARP III) with the clinical years of the sive summary of the candidate's attributes, abilities, and curriculum. In the case of unsatisfactory progress, as performance. evidenced by failing grades or an inability to develop A Pass/ Fail grading system is employed for the first adequate clinical expertise, the appropriate committee semester of the first year. At the conclusion of each may require that the student be reexamined or repeat the academic year every student receives a grade report that relevant courses. If a student does not achieve or maintain indicates achievement in each course taken. When all the a satisfactory level of scholarship, the Committee may in i 1 drop the student from the School. Any action to drop a semester, and will be eligible for individual tutorial help in student from the School will be the result of a determina- the remaining courses. At the end of the first semester the tion by a CARP Committee (on the basis of the student's Committee may require a student who has failed one or performance and on the judgment of the members of the more of the major courses to enter an individualized faculty who are familiar with him), that he has demon- program. strated an inability to successfully complete the require- A student who has been required to enter an indi- ments of the School for the degree of doctor of medicine. vidualized program is expected to pass all of his assigned A decision by a CARP committee to drop a student courses in order to continue in subsequent semesters in from the School may be appealed. The appeal must be the School of Medicine. If a student should fail any major submitted, in writing, to the Dean of the School of Medi- course, one reexamination will be offered in each course cine within 72 hours of the student's receipt of notification at some time before the end of the summer preceding the of the Committee's decision. Appeals will be considered next academic year. Should the student fail any reexami- within 30 days by a standing Appeals Committee ap- nation, in the absence of such extenuating circumstances pointed by the Dean. The Appeals Committee has limited as personal ill health (physical or mental), he will be authority either to uphold the earlier decision of the dropped from the School. In the second year of the relevant CARP committee or to recommend to the Dean individualized program the student shall complete all that the student be reinstated and allowed to continue his remaining first-year courses. If scheduling permits, and studies in the School. The reversal of a decision by a with the permission of CARP I, selected courses in the Committee on Academic Review and Promotions will be second-year curriculum may be taken. based only on a presentation of: (1) information which is new and/ or different from that previously received by the Second-Year Curriculum CA R P Committee; or (2) evidence of extreme hardship of If a second-year student fails a course, one reexami- which the CARP Committee was not fully apprised. nation is permitted. Should the reexamination be failed, the course must be repeated. Failure in the repeated First-Year Curriculum course will result in the student's being dropped from the The Committee on Academic Review and Promo- School of Medicine by CARP II. If a second-year student tions I may recommend to any first-semester student who had been on an individualized program for the whose performance reflects difficulties with the required first-year curriculum fails a second-year course, that fail- course work that he enter an individualized program. The ure can be removed by passing a reexamination. Failure Committee's recommendation will be based on a review in the reexamination, in this case, constitutes grounds for of the student's performance in the first or second exami- CARP II to drop the student from the School of nations in one or more of the major* first semester Medicine. courses. The intent of such an individualized program is to permit the student an optimum chance of successfully completing the requirements for the first year by permit- *The term "major courses" refers only to the first-year courses. ting him to take up to two years to complete the first Biological Chemistry, Microbiology, and Gross Anatomy, year's work. Students who accept the Committee's rec- which are currently taught in the first semester, and Physiology, ommendation will be permitted to withdraw from one, or Microscopic Anatomy and Neural Science, which are currently at the most two, of the major courses taught in the first taught in the second semester.

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] n No student may take more than three years to com- RESIDENCY TRAINING plete the course work required for the first two years of the Although not required by all states for licensure, curriculum. The Committee on Academic Review and postgraduate residency training in an approved hospital is Promotions 11 will neither promote a student to the status considered essential preparation for the practice of medi- of candidate for the Doctor of Medicine degree nor per- cine. Most Washington University graduates serve three mit a student to begin a clinical clerkship until all first- or more years of residency training, and some will gain and second-year course work has been satisfactorily additional experience as postdoctoral fellows. completed. In order to aid students in obtaining desirable residency appointments, an active counseling program is Beyond the Second-Year Curriculum maintained by the Assistant Dean for Postgraduate Train- The Committee on Academic Review and Promo- ing. Thus, in their junior year, students are provided with tions III meets at least twice each year to review the general background information about the kinds of resi- academic progress of all students who have been pro- dencies available. Since more residencies exist than there moted or admitted to the status of candidate for the are candidates in any given year, students are able to degree of doctor of medicine. This includes students in the regular four-year degree program, students taking a five- exercise a considerable degree of selectivity. year degree program, students in the clinical portion of The Assistant Dean for Postgraduate Training main- the Medical Scientist Training Program, those selected tains an open file of brochures and other descriptive data students with a prior Ph.D. degree who have been regarding residencies throughout the country. Included approved by the Medical Science Training Placement are evaluations of their own residencies obtained from Curriculum Committee for individalized curricula and our recent graduates. The School participates in the are now in the clinical training period of their program National Resident Matching Program, which offers dis- (having previously been promoted to the status of candi- tinct advantages to applicants. date for the degree of (Doctor of Medicine), and all others The School maintains an active interest in its gradu- who have successfully completed all aspects of the ates and is pleased to assist them in subsequent years as School's preclinical curriculum. Just prior to the end of they seek more advanced training or staff appointments each academic year, the Committee meets and recom- in the communities in which they settle. mends to the Executive Faculty those students who, in the POSTDOCTORAL TRAINING opinion of the Committee, are qualified to receive the Those departments which offer Postdoctoral Fel- degree of Doctor of Medicine. Specific rules are as lowships individualize such educational activity up to a follows: maximum of 36 months of academic time. Such fellow- 1. All academic encumbrances must be removed in ships lead integrally to certification by the appropriate order for a student to be recommended for specialty and/or subspecialty boards of the American graduation. Medical Association. 2. A candidate having failures in two subjects may, at the discretion of the Committee, be dropped from the School or may continue with an individualized program.

STUDENT RESEARCH FELLOWSHIPS No matter what medical career an individual chooses, it will be essential for him to evaluate and use fresh knowledge as he moves through his professional life. Student Research Fellowships in basic science or clinical areas, awarded each year to selected students who undertake research projects under the direction of faculty members, are an important part of the educational program. Research allows students to discover firsthand the problems and rewards of obtaining and assessing new information, thus adding another dimension to their experience as investigators. Selected faculty members serve as advisers to students interested in special research opportunities. Fellowships are available to students after acceptance into the School. They are granted for a minimum of two months. The research must be undertaken during the student's free time or a vacation period. A number of studies conducted by students are reported in scientific journals. 12 i :

other than the few in the natural sciences, are not pre- Admission sented as prerequisite because a great variety of courses may prepare the student for the many roles he may play in ENTRANCE REQUIREMENTS his medical career. Entrance requirements to the School of Medicine are: APPLICATION PROCEDURE 1. evidence of superior intellectual ability and The Washington University School of Medicine par- achievement; ticipates in the American Medical College Application 2. completion of at least 90 semester hours of' Service (AMCAS) of the Association of American Medi- college courses in an approved college or cal Colleges. AMCAS is a centralized procedure for university; applying to any participating medical school with only 3. completion of the New Medical College Ad- one application and one set of official transcripts of aca- mission Test of the Association of American demic work. Medical Colleges; The AMCAS Application for Admission, common 4. evidence of intellectual ability, character, to all participating medical schools, is distributed by the attitude, interests, motivation and superior AMCAS and preprofessional advisers. For this reason, scholastic achievement suitable for a career individuals requesting an application and a Bulletin from in medicine. Washington University will receive an AMCAS Applica- Chemistry, physics, and mathematics provide the tion Request Card and a brochure describing the School tools for modern biology, for medicine, and for the biolog- of Medicine. The Bulletin is mailed to candidates upon ical basis of patient care. Thus, a firm grounding in these subjects is essential for the study of medical sciences. Entering students are expected to have had at least the equivalent of one-year courses at the undergraduate level in physics and biology; to have studied mathematics through integral calculus; and to have a background in chemistry, including organic chemistry. A course in physical chemistry (with calculus as a prerequisite) is strongly recommended. In selected instances, one or more of these prerequisites may be waived by the Committee on Admis- sions, but applicants are strongly advised to pursue their interests in these and in other areas of science. A major goal of undergraduate college work should be development of the intellectual talents of the individual. This often involves the pursuit of some area of knowledge in depth, whether in the humanities, social sciences, or natural sciences. At the same time, a diversity of background is encouraged in order to provide a necessary foundation for cultural development. Specific courses,

13 receipt of their application credentials from AM CAS. applicant to meet and talk with students and faculty Applicants are urged to file their applications as early members. as possible. If an applicant is planning an interview trip which will include the St. Louis area, it is appropriate for him to Early Decision Admission write the Interview-Appointments Secretary, Committee This is an optional program for the applicant whose on Admissions. Box 8107, Washington University School first-choice school of medicine is Washington University of Medicine, 660 South Euclid Avenue, St. Louis, and who desires an admission decision on his application Missouri 63110, and inquire if an interview will be reno later than October I, 1982. To receive this special quested of him. The inquiry should be made at least three consideration, the applicant must agree to: (1) apply only weeks in advance of the anticipated travel. The Office of to Washington University prior to receiving its admission Admissions is open on weekdays from 8:30 a.m. to 5 p.m. decision; (2) present an academic record of 90 semester central time. hours that indicates completion, or plans for completion, of all courses required for admission; (3) have a superior Accepted Applicants academic record and correspondingly strong scores on Upon notification of acceptance for admission to the the New Medical College Admission Test; (4) submit all School, the applicant is required to file a Statement of required credentials to AMCAS by August I, 1982; (5) Intent. Three options are presented: 1) accept the offer of visit the Medical Center for interviews on a mutually admission and submit the $100 reservation deposit; 2) convenient date prior to September 1,1982; and (6) accept accept the offer of admission, submit the $100 deposit, a position in the class, if offered one. There is no quota on and request financial aid materials; and 3) decline the the maximum number of positions in the class of 120 to be offer of admission. The $ 100 acceptance deposit reserves a filled by Early Decision applicants. The AMCAS Appli- place in the class and is applied to the tuition charge at the cation for Admission contains complete instructions time of matriculation. If an accepted applicant withdraws regarding Early Decision programs. from the class, with written notification to the Admis- sions Office, prior to June 16, 1983, the deposit is Regular Admission refunded. All applicants to the Washington University School of Medicine must submit their application to AMCAS by THIRD-YEAR CLASS TRANSFER November 1, 1982. On receipt of the application from PROGRAM AMCAS, the Committee on Admissions promptly for- Each year the Washington University School of wards to applicants the additional materials that must be Medicine accepts approximately twenty transfer students submitted to complete the application process. At this into its third-year class. This class enlargement is permit- stage, a nonrefundable Application Service Fee of $35 is ted because of the abundant clinical training facilities charged by the University. Once complete, the applicant's available in the Medical Center and because of the exist- admission credentials are reviewed and independently ence of a national need for such transfer positions. evaluated by members of the Committee on Admissions. Transfer applications are accepted from well-qualified Selected applicants are invited for a personal interview. students in the U.S. medical schools where limited facili- Final decisions are made by the 20-member faculty com- ties require some students to transfer elsewhere for clinical mittee. Washington University School of Medicine oper- training. Applications are also accepted from students in ates on a rolling admissions schedule beginning October U.S. schools of medicine who have a cogent reason for 15, and applicants are notified as soon as a final admission requesting transfer and who have the full approval of the decision has been made on their application. By May 15, dean of their current school. 1983 every applicant should have a final decision— Transfer application forms for our 1983 third-year accepted, waiting list, or not accepted. class are available on August 1, 1982. Application dead- Personal Interview line is November 1, 1982. Those applicants selected for interview will be invited to visit the Medical Center during The Committee on Admissions would like to inter- November 1982. All applicants will be notified of the view every applicant who passes the initial evaluation decision of the Committee on Admissions by December screening process, but since this involves several thousand 31, 1982. Inquiries should be directed to: applicants, it is physically impossible to accomplish. Therefore, selected applicants are invited to visit the Third-Year Class Transfer Program Washington University Medical Center for an interview, Washington University School of Medicine as well as a tour of the School of Medicine and its 660 South Euclid Avenue—Campus Box 8077 hospitals. This visit will provide an opportunity for the St. Louis, Missouri 63110 14 ■i T

Financial Information COST OF EDUCATION, 1982-83 FIRST YEAR CLASS For a first-year matriculant, tuition and housing rates for the 1982-83 academic year are listed below. Although the University reserves the right to change the fees at any time without notice, any change will not become effective until the 1983-84 academic year. Other items listed provide an estimate of the expenses for a single student in the 36-wcck first-year class. The total of these figures suggests a basic minimum budget of approximately $13,191. Allowances for entertainment, travel, clothing, and other miscellaneous items must be added to this estimate. Tuition (includes Student Health Service and Microscope Lending Plan) $8,500 Books 600 Supplies and instruments 500 the academic year 1982-83 solicits information about the Housing (single room, applicant and parents, including a detailed description of Olin Residence Hall) 1,449 resources and liabilities. In addition, it requests informa- Board (Medical Center cafeterias) 2,142 tion about the income, expenses, education and employ- Student Health Service ment history of the student's spouse (or spouse-to-be). The School asks that the statement be forwarded The Student Health Service provides comprehensive promptly, within two weeks from date of receipt, to health care, including hospitalization, for all students in GAPSFAS for processing. the School of Medicine. Health insurance coverage for Financial aid award decisions are made by the five- dependents of students can be arranged. member Committee on Student Financial Aid, and Microscope Lending Plan applicants are notified of the award decision within two Microscopes which meet the technical requirements weeks of the date the processed Financial Statement is set by the faculty are provided to each student in the first- received from GAPSFAS. An official copy of the parents' and second-year classes. The Plan saves the student the and the applicant's U.S. individual income tax return high cost of microscope purchase and makes available to completes the data required for financial aid considera- them a superior quality instrument. tion. All information is held in strict confidence. Financial aid awards are credited toward payment of FINANCIAL ASSISTANCE tuition and fees. Proceeds from loans may be disbursed The ability to finance a medical education at directly to the borrower. The loan portion of an award Washington University does not influence the student will be funded through the resources of the School of selection process. As all students accepted for admission Medicine or through the Guaranteed Student Loan have proven scholastic ability, financial assistance is (GSL) program. All loans awarded by the Committee are awarded solely on the basis of documented financial need free of interest while a student is enrolled in the School. which cannot be met by student and family resources. Financial aid awards are made for a given academic Students who consider themselves financially indepen- year. Students may reapply for financial assistance in dent of their parents must arrange for loans to replace the succeeding years of medical school if they remain in good amount of support parents are analyzed to have the academic and personal standing, and if there is continued potential to contribute. The School of Medicine's Office financial need. Awards made to a student may vary from of Financial Aid (Box 8059) will assist students in making year to year, depending upon the student's needs and these arrangements. upon the availability of funds to the Committee. Students At the time accepted students indicate they will are responsible for filing applications for renewal of matriculate in the School of Medicine, they may request awards in the spring of each year. an application for financial aid. The Graduate and Pro- The Committee holds that students receiving assis- fessional School Financial Aid Service (GAPSFAS) tance have an obligation to notify the Committee if their Financial Statement and other financial aid material, financial situation changes, for example, through employ- information, and instructions will be sent to the students ment or receipt of a scholarship not anticipated at the by return mail. The GAPSFAS Financial Statement for time the application was submitted. J 15 First- and second-year students are urged not to Scholarship Funds accept employment during the academic year. A number Gilbert L. Chamberlain, M.D., Scholarship Fund. of fourth-year students find employment in hospitals Created in 1971 by Dr. Gilbert L. Chamberlain to be used within the Medical Center. The Personnel Office provides to aid worthy students in acquiring their medical assistance to students' spouses seeking employment. education. Students must agree to not travel outside the conti- Cecil M. Charles—Nu Sigma Nu Medical Student nental United States during the academic year in which Scholarship Fund. Established by the Nu Sigma Nu Med- they receive financial aid from the School. ical Fraternity in memory of Dr. Charles. Grace Strong Coburn Scholarship Fund. Created in Washington University School of Medicine Merit 1962 through the bequest of Mrs. Grace Strong Coburn Scholarships for scholarships in the School of Medicine. The School has established five full-tuition scholar- T. Griswold Comstock Scholarships. Established ships to be awarded annually to members of the entering under the will of Marilla E. Comstock for students who first-year class. The scholarships will be awarded, without would otherwise be unable to obtain a medical education. regard to financial need, to students of proven academic Dr. Charles Drabkin Scholarship Fund. Created in excellence. In early fall 1982 selected applicants to the 1964 to provide financial assistance to medical students. School's 1983 first-year class will be invited to file applications for scholarship consideration. Selection will be Robert Elman Scholarship in Surgery. Created in made by a committee of the faculty and will be based on 1980 through the bequest of Minna Elman in memory of her husband. demonstrated superior intellectual achievement as well as an assessment of the applicant's character, attitude, moti- Carl Fisch Scholarship Fund. Created in memory of vation, and maturity. The announcement of the 1983 Dr. Fisch by his daughter, Marguerite F. Blackmer. Pro- scholarship recipients will be made on March I, 1983. vides support to students who demonstrate financial The scholarships are subject to annual renewal. need. Recipients of these scholarships will be expected to main- George F. Gill Scholarship Fund. Instituted in tain academic excellence. If a scholarship is not renewed, memory of a former clinical professor of pediatrics. the student may file for financial aid from the School. Harvielle-Bailey Scholarship. Established in 1970 A scholarship recipient may not concurrently hold under the will of M iss Isabel Bailey Harvielle as a memo- an Olin Fellowship from Washington University, or par- rial to Dr. Charles Poplin Harvielle and Dr. Steele Bailey, ticipate in the School's Medical Scientist Training Pro- Jr., alumni of the School. gram, the National Health Service Corps Scholarship Dr. Grace Huse Memorial Fund. Provides scholar- Program or the Armed Forces Health Professions Schol- ship awards for deserving Washington University medical arship Program. Scholars may apply to the School for students. financial aid in addition to the full-tuition scholarship. Insurance Medical Scientist Scholarship Fund. Additional aid would be determined on the basis of doc- Established for the training of promising scholars intent umented financial need. upon a career in research and academic medicine. Jackson Johnson Scholarship Fund. Provided through a bequest in 1930 from Jackson Johnson. i-i IMMK-Jll Henry J. Kaiser Family Foundation-Medical Cen- tury Club Scholarship Fund. Following the Foundation's generous gift in 1980 for medical student scholarships, the Medical Century Club accepted the challenge to raise new scholarship funds to match an additional gift from the Foundation. George D. Kettelkamp Scholarship Fund. Estab- lished in 1969 by Mrs. Kettelkamp in memory of her husband, an alumnus of the School of Medicine. & Rx |t)UUl m Albert F. Koetter, M.D., Scholarship Fund. Estab- |UUUl(^) lished in 1978 by Mrs. Stella Koetter Darrow in memory fe*Q of her father, an alumnus and former faculty member of the School of Medicine. At least one full-tuition scholar- ^)^Rx & ship is awarded annually on the basis of academic achievement and financial need. Washington University School of Medicine Merit Scholarships Maude L. Lindsey Memorial Scholarships. Created in 1976 to assist students in the School of Medicine. Eliza McMillan Scholarship Fund. Provides assistance to young women in any of several schools of the University to secure an education. it. Medical Center Alumni Scholarship Fund. Tuholske-Jonas- Tuholske Medical Scholarship Awarded on the basis of academic achievement and Fund. Established in 1974 by Rose T. Jonas in memory of financial need. her father, husband, and brother. The recipient shall be a Roy B. and Viola Miller Memorial Fund. Created in senior student preparing to enter the field of surgery, 1963 through the bequest of Roy B. Miller to provide obstetrics and gynecology, or internal medicine. scholarships for medical students and for postgraduate students engaged in study and research in the medical Scholarship and Loan Funds sciences. Isabel Valle Brookings Scholarship and Loan Fund. Mr. and Mrs. Spencer T. Olin Fellowships for Established in 1957 by Isabel Valle Brookings (Mrs. Women. Provides for annual financial support to women Robert S.) for scholarships and loans in the School of in any of several disciplines. Application deadline is Medicine. February 1. Danforth Foundation Loan and Scholarship Fund. William B. Parker Scholarship Fund. Established in Provides financial assistance for medical students. 1976 by the School of Medicine in honor of William B. Danforth Medical Foundation Fund. Created Parker's fifty-one years of service to the School. through gifts from the Danforth Foundation and the late Henry and Louise Reller Scholarship. To be given to William H. Danforth to furnish loans, scholarships, or medical students in the name of the parents of Louise outright grants to talented and promising young men and 1 Reller. women engaged in study or research in basic medical or Samuel Jennings Roberts Scholarship Fund. clinical sciences. Created to provide scholarships for any students engaged Paul H. and Lila L. Guttman Student Aid Fund. in study leading to the degree Doctor of Medicine. Established in 1976 to provide financial assistance to Robert Allen Roblee Scholarship Fund. Established qualified medical students. in 1948 through the gift of Mrs. Joseph H. Roblee for Robert Wood Johnson Foundation Fund. Created students in the School of Medicine. in 1972 to provide financial assistance for students who Thomas W. and Elizabeth J. Rucker Scholarship are from rural backgrounds, members of specified minor- Fund. Created in 1956 under the will of Eugenia 1. ity groups, and women. Rucker, in memory of her mother and father. William H. and Ella M. Schewe Fund. Established Joseph H. Scharf Scholarship Fund. Provided in to provide financial assistance to worthy students in the 1949 through the bequest of Dr. Joseph H. Scharf. medical school. School of Medicine Scholarship Fund. Created in School of Medicine Loan and Scholarship Fund. 1970 to provide financial assistance for medical students. Created in 1970 to provide financial assistance for medical students. Dr. John B. Shapleigh Scholarship Fund. Estab- Wilkinson Scholarship Fund. Created in 1968 by the lished in 1926 with the bequest of Dr. John B. Shapleigh bequest of Anna J. Wilkinson in honor of her husband, and supplemented by contributions from Mrs. Shapleigh Dr. George E. Wilkinson. Medical and postdoctoral stu- and Miss Margaret Shapleigh. dents are eligible for Wilkinson scholarships or loans. Alexander Balridge Shaw Scholarship Fund. Created in 1958 through the bequest of Roy A. Shaw in memory of his father, Dr. Alexander Balridge Shaw. Beulah B. Strickling Scholarship Fund. Established in 1960 with a bequest from Mrs. Beulah B. Strickling. Marleah Hammond Strominger Scholarship. Es- tablished in 1971 by the family and friends of Marleah Hammond Strominger. The recipient shall be a moti- vated student with need for financial assistance and shall come from a disadvantaged background. Edwin H. and Virginia M. Terrill Scholarship Fund. Established in 1964 with the bequest of Dr. Edwin H. Terrill, an alumnus. It was Dr. Terrill's hope that scholarship recipients would repay into the Fund the amount of the award. Mildred Trotter Scholarship Fund. For students with documented financial need, the fund was established in 1979 by Dr. and Mrs. Paul Guttman, and supplemented by former students of Dr. Trotter, as a tribute to her many years of teaching in the Department of Anatomy. Hiromu Tsuchiya Scholarship Fund. Created to provide scholarships in the School of Medicine.

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Health Professions Student Loan Fund. Established by federal legislation for medical students with a demonstrated financial need. Loans are available for long terms at favorable rates. Ursula Hecker Loan Fund. Established in 1967 by a bequest from Ursula Lee Hecker for the use and benefit of worthy, deserving, and needy medical students. W. K. Kellogg Foundation Loan Fund. Provides financial assistance to medical students in need of such aid. Gustel and Edith H. Kiewitt Scholarship Loan Fund. Provides loan funds for medical students. Ophelia H. Kooden and Violet G. Sachs Loan Fund. Created in 1970 to provide loans for medical students in memory of the donors' brother, Jess Klement Goldberg. National Direct Student Loan. A federal program to provide loans to students with financial need. Permits repayment over an extended period at a favorable interest rate. G. H. Reinhardt Memorial Scholarship Loan Fund. Established in 1947 through the bequest of G. H. Reinhardt. Aline Rixman Loan Fund. Created in 1940 by William Rixman in memory of his wife, the fund is used to alleviate unexpected financial emergencies of medical students. Robert Wood Johnson Foundation Student Loan Guarantee Program. Provides "a last-resort source of funds for educational expenses." Caroline O. Schlesinger Loan Fund. Established in 1969 to provide financial support for medical students. School of Medicine Student Loan Fund. Estab- lished to make loans to students with documented financial needs. Washington University Medical Center Alumni Association Loan Fund. Provides emergency loans to medical students. Fellowship and Other Funds Alexander and Gertrude Berg Fellowship Fund. Created in 1952 through the bequest of Gertrude Berg to provide a fellowship in the Department of Microbiology. Glover H. Copher Fellow in Surgical Research. Established in 1971 to support a postdoctoral fellow in surgery. William H. Danforth Loan Fund for Interns and Loan Funds Residents in Surgery. Provides financial assistance in the American Medical Association Loan Program. form of loans for postdoctoral students in surgery. Makes available bank loans without collateral to eligible J. Albert Key Fellowship Fund. Provides a stipend medical students, interns, or residents who are citizens of for a fellow in orthopedic surgery. the United States. Applications for such loans are made Louis and Dorothy Kovitz Fellowship Fund. Estab- through the Education and Research Foundation of the lished in 1970 by an alumnus and his wife to provide American Medical Association. support for research by qualified residents or students Ruth Elizabeth Calkins Scholarship Loan Fund. interested in surgery, at the discretion of the Head of the Established by Dr. Delevan Calkins in honor of his Department of Surgery. granddaughter. George W. Merck Memorial Loan Fund. Estab- Federally Insured Student Loan. Washington Uni- lished in 1959 through the Merck Company Foundation versity acts as the lender for students awarded loans by the to encourage deserving interns and residents to seek the School of Medicine. best possible postdoctoral training. IS 1 Stephen I. Morse Fellowship. Established in 1980 by C1BA Award for Outstanding Community Service. Carl and Belle Morse in memory of their son; awarded to Recognizes a sophomore student who has performed predoctoral or postdoctoral students pursuing research laudable extracurricular activity within the community. careers in microbiology, immunology and infectious Carl F. and Gerty T. Cori Prize in Biochemistry: diseases. Awarded at the end of the first year to the member of the The Esther and Morton Wohlgemuth Foundation class who has demonstrated superior scholarship in bio- Fellowship. Established to support a fellow in the Divi- chemistry. sion of Cardiovascular Diseases. Edmund V. Cowdry Prize in Histology. Established Student Research Fellowships. Awarded each year in 1969 to honor Dr. Cowdry; awarded to a freshman to students who undertake special research projects under medical student who has performed meritoriously in the direction of a faculty member. They carry a stipend. microscopic anatomy. Application should be made to the Committee on Fellow- Antoinette Frances Dames Prize in Physiology and ships and Awards, which supervises the program. Biophysics. Awarded annually to a member of the first- year class who has demonstrated superior scholarship in Awards and Prizes these fields. Alpha Omega Alpha Book Prize. Awarded at the George F Gill Prizes. One prize awarded at the end end of the fourth year to a member of that class who has of the first year to a member of the class who has demon- performed outstandingly for the entire medical course. strated superior scholarship in anatomy; one prize Alexander Berg Prize. Awarded to the student pre- awarded to a member of the graduating class who has senting the best results in research in bacteriology. demonstrated superior scholarship in pediatrics. Jacques J. Bronfenbrenner Prize. Provided by Dr. Bronfenbrenner's students in memory of his inspiration Alfred Goldman Book Prize. Created in 1972 as an as a teacher and scientist, and awarded to the member of annual award to be given to a student in the School of the graduating class who, in the judgment of the Chair- Medicine who, in the opinion of the faculty, has done man of the Department of Medicine, has done the most outstanding clinical or research work in diseases of the outstanding work in infectious diseases or related fields. chest or pulmonary physiology. Dr. Richard Brookings and Dr. Robert Carter Med- Dr. J. E. Kirk Scholastic Award. Established in 1975 ical School Prizes. Provided for medical students through and awarded to a graduating student of high scholastic a bequest of Robert S. Brookings. standing. Kehar S. Chouke Prize. Awarded at the end of the Louis and Dorothy Kovitz Senior Prize in Surgery. first year to a medical student who has demonstrated Senior award prize in surgery recognizing a member of superior scholarship in anatomy. the senior class who has shown the most outstanding ability, zeal, and interest in surgical problems. Lange Medical Publications Book Awards. Given to members of all four classes for high scholastic standing and achievement in research. Irwin Levy Memorial Fund. Established in 1980 by friends of Dr. Levy as a tribute to his commitment to clinical teaching. Provides a prize for the student who presents the best performance in the neurology and neurological surgery clerkship. Oliver H. Lowry Prize. Awarded to second-year medical student for academic excellence in pharmacology. Howard A. McCordock Book Prize. Awarded at the end of the second year to a member of that class for general excellence in pathology. Edward Massie Prize for Excellence in Cardiology. Awarded to the member of the graduating class who, in the judgment of the Director of the Division of Cardio- vascular Disease of the Department of Medicine, has done the most outstanding clinical or basic research work in the field of cardiovascular disease. Medical Center Alumni Scholarship Prize. Given annually to a student who has shown excellence in his work during the preceding year. Medical Fund Society Prizes. One prize awarded annually to a student of the senior class who has excelled in the study of internal medicine; one prize awarded J 19 I annually to a student of the senior class who has excelled done meritorious clinical and/or research work in the in the study of surgery. No individual is eligible for both Division of Cardiovascular Diseases of the Department prizes. of Medicine. Missouri Stale Medical Association Award. Ascroll Margaret G. Smith Award. Given to a woman medi- and a U.S. Savings Bond presented annually to an honor cal student for outstanding achievement in the first two graduate of the senior class. years of medical school. C. V. Mosby Company Book Awards. Made to five Samuel D. Soule Award in Obstetrics and Gynecol- members of the graduating class for high general scholas- ogy. Presented to a member of the junior or senior class tic standing and research achievement. for meritorious achievement in either basic or clinical James L. O'Leary Neuroscience Prize. Awarded investigation in obstetrics and gynecology. annually to students who demonstrate the best accomp- Upjohn Achievement Award. Given to the senior lishments in the neuroscience course. student who has done the most meritorious work during James L. O'Leary Prize for Research in Neuro- his medical school career in the field of metabolism. science. Given annually to a prcdoctoral or postdoctoral Washington University School of Medicine Aca- student for the most original and important accomplish- demic Achievement Award. Given annually to a student ment in neuroscience research. who has exhibited to an unusual degree the qualities of St. Louis Internists Club Book Prize. Awarded to industry, perseverance, determination, and enthusiasm in the graduating senior who has done the most significant the first-year academic program. research in any area of internal medicine. Samson F. Wennerman Prize. Donated by his wife, St. Louis Pediatric Society Senior Prize. Presented Zelda E. Wennerman, and awarded annually to that to the senior student showing the greatest promise in senior student who has demonstrated promise in surgery. clinical pediatrics. Hugh M. Wilson Award for Meritorious Work in Sandoz Award. Given annually to a graduating stu- Radiology. Given annually to a graduating medical student who has made a meritorious contribution to psychi- dent in recognition of outstandiong work in radiology- atric research. related subjects, either clinical or basic science. Sidney I. Schwab Prize in Psychiatry. Awarded at James Henry Yalem Prize in Dermatology. Estab- the end of the fourth year for general excellence in lished by Charles Yalem in memory of his son and psychiatry. awarded annually to a member of the senior class for John R. Smith Memorial Fund Prize. Created in outstanding work in dermatology. 1982 to be awarded annually to a medical student who has

c I I c I 20 c i Student Life HOUSING The Apartment and Housing Referral Services, located in the Millbrook Building on the West Campus, Box 1059, Washington University, St. Louis, Missouri 63130, telephone (314) 889-5092, maintains listings of housing appropriate for married and single students. The Spencer T. Olin Residence Hall has accommodations for approximately 250 single men and women. This building, made possible by generous gifts from Spencer T Olin and alumni and friends of the School of Medicine, is located at 4550 Scott Avenue in the Medical Center. Olin Hall is planned for the convenience of students in the medical or paramedical sciences. Every effort is made to provide an atmosphere that not only aids them in meeting their study obligations, but also recognizes their privileges as graduate students. The rates for rooms during 1982-83 are: School Year: September-June (Nine Months) •' ■*■«£. .-ii; !jf? Two-room suite $ 1,665 ~*M i f# # ' ^"■"■Ste*- --J^^A. Single room 1,449 ■ -Wl Double room 1,152 jyf-^jgs^' fl\ ^vSti 1 Large single 1,782 ■ tr "»' Summer 1982: for Three Months Two-room suite 555 Wj/fi Single room 483 Double room 384 Large single 595 Wr ' ■' ■ fc Summer 1982: Weekly Rates for Student Visitor Two-room suite 70 $ ' Single room 60 Double room 50 VlA■ » N. 3#" Daily Rates for Visitors ♦ Two-room suite 30 1 I Single room 25 Single room (prospective student) 20 Each occupant is required to pay a $25 security fee in addition to the room rental charge. This fee will be held by the University until termination of residence to cover losses resulting from possible damage to the room or the furniture. Any portion not so used will be refunded.

STUDENT HEALTH SERVICE Entering students are given a complete medical examination and are provided with medical care as long i as they are enrolled in the School of Medicine. Physicians are available at the Student Health Service, and a physician is on call for emergency care at Barnes Hospital. Essential costs of hospitalization are covered. The student or his family is responsible for meeting the costs of hospital care in excess of those paid by the Health Service. The responsibility of the Student Health Service for hospitalization costs will end 30 days after a hospitalized individual ceases to be an officially enrolled student.

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RECREATIONAL AND CULTURAL OPPORTUNITIES St. Louis is a city in the center of things, stylistically as well as geographically. Here, the industriousness of the North is tempered by the graciousness of the South, while Eastern respect for tradition is balanced by the pioneering spirit of the West. A metropolitan area of more than 2.5 million T people, St. Louis has one of the most diversified econo- Except in certain emergencies, costs will not be mies of any major U.S. city. Among other endeavors, its covered for outpatient care that is not arranged through workers are engaged in the aerospace industry, automo- the Student Health Service. bile assembly, brewing, shoe manufacturing, and chemical production. PARKING The city's cultural and recreational opportunities Parking is available on lots owned and operated by reflect a similar eclecticism. There are 26 institutions of the School of Medicine. These lots are located near Olin higher learning in the area, as well as libraries, museums, Hall and various other sites within the Medical Center. professional drama companies, a dance society, opera The Busch lot, owned jointly by Barnes Hospital and the theatre, and the second-oldest symphony orchestra in the University, is located between Taylor and Newstead nation. Frequent appearances by various popular record- Avenues. An annual permit must be purchased for use of ing artists round out the city's cultural opportunities. L either of these two facilities. These permits are available to St. Louis is served by 18 radio stations, and one ' students—on a limited basis. Students also qualify to educational and five commercial television channels. Two purchase monthly permits in the Washington University— daily newspapers of opposing political views are pub- Wayco Garage at the corner of Audubon and Euclid lished in the city—the morning Globe-Democrat and the C Avenues. evening Post-Dispatch.

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: For spectators, there are four major-league sports nized as recipients of the Annual Alumni-Faculty teams—the baseball and football Cardinals, soccer Achievement Awards. Additional recognition is given to Steamers, and the hockey Blues. For participants, the alumni based on exemplary professional achievement four vibrant seasons make outdoor recreation a favorite and service to the School. pastime. Good country for hiking, camping, canoeing, Each year the Alumni Association sponsors the and spelunking is just a short drive from the city. Annual Clinical Conference held in February, receptions The construction of the Gateway Arch, the proud at major medical conferences, and a welcoming party for symbol of the key role St. Louis played in the nation's new house officers. westward expansion, sparked an urban renaissance in the A new program established to foster alumnus- 1960s, and the city is now enjoying the results. Within the graduate relations matches alumni in various cities with past few years, the downtown business district has under- new graduates just beginning their training. gone a dramatic transformation, with the opening of a Another new program, the Alumni Network pre- convention center, new hotels, and a riverfront enter- sents special alumni programs in selected cities across the tainment district. Some of the city's historic residential United States. Each event will be tailored to the interests neighborhoods, such as Lafayette Square and Soulard, of the medical alumni in the metropolitan area. A special have recently been rediscovered by modern homesteaders, seminar/lecture series is being prepared for alumni and who are restoring once-elegant townhouses to their their spouses in greater St. Louis. former glory. Alumni Reunion Days are in May and feature a Washington University's School of Medicine is scientific program presented by the Office of Continuing located in a district known as the Central West End—a Medical Education, a traditional welcoming cocktail diverse neighborhood which includes quiet private streets, party, individual class dinners, the Dean's Luncheon, and high-rise apartment buildings, and many small shops, the Annual Alumni Dinner Dance at which the 50-year restaurants, and galleries. Under the auspices of the reunion class and the graduating seniors are honored Washington University Medical Center Redevelopment guests. This program is designed to reacquaint returning Corporation, this area, too, is experiencing a alumni with the continued vitality of their alma mater. resurgence of interest from both commercial and residen- Membership is available to graduates of the School tial investors. of Medicine, members of the faculty, and all former house One of the city's major attractions, Forest Park, is officers of the Medical Center. bounded on the west by the campus of Washington Uni- versity and on the east by the Washington University Medical Center, which includes the School of Medicine. CONTINUING MEDICAL EDUCATION Originally the site of the St. Louis World's Fair, this PROGRAM 1400-acre expanse of greenery and recreation facilities has With encouragement and financial support from the paths for running and cycling, courts for tennis and hand- Washington University Medical Alumni, the School of ball, a skating rink, fishing ponds, fields for football, Medicine in 1973 set up the Office of Continuing Medical baseball and soccer, and three golf courses. Also located Education. The objectives of this program are: within the Park are the St. Louis Zoo, McDonnell 1) To provide high quality educational activities for Planetarium, Museum of the Missouri Historical Society, alumni of Washington University School of Medicine Jewel Box Floral Conservatory, City Art Museum, and and other physicians regionally and, on occasion, Municipal Opera. nationally. 2) To encourage life-long learning by a variety of educa- WASHINGTON UNIVERSITY MEDICAL tional methods appropriate to the learners' needs. CENTER ALUMNI ASSOCIATION 3) To provide for the acquisition of new knowledge and The Washington University Medical Center Alumni skills and to aid in acquiring efficient problem-solving Association was organized to foster a spirit of class fellow- techniques for ultimate improvement in patient care. ship among its members. It assists the School of Medicine 4) To provide a forum where academic and practicing by stimulating an interest in the advancement of medical physicians can jointly explore solutions to health and collateral sciences by supporting postgraduate problems. studies. 5) To translate the results of research and the habits of In order to further the aims and purposes of the critical assessment of new data to the needs of practic- School, the Association sponsors a variety of programs ing physicians. designed to complement the philosophy of the institution. In the first year the office sponsored five programs, Student-Alumni activities include an Emergency Student and it has subsequently grown to 25 to 30 symposia Loan Fund, a High School Honors Day, a Freshman annually. About 3,000 registrants attend these courses Visitation-Orientation Day, and a Pre-Med Exposure annually and receive more than 300 hours of instruction. Program. In addition to formal courses, the CME Office has spon- Alumni who are distinguished members of the sored computer assisted instruction, medical and pediat- Washington University School of Medicine are recog- ric newsletters, audiotapes, mini-residencies, a speaker's I 23 c

bureau, and supported continuing medical education in Carl Gayler Harford Lectureship. Established in community hospitals. 1977 by the family of one of Dr. Harford's patients in gratitude for his contributions to teaching clinical medi- LECTURERSHIPS AND VISITING cine and virology. c PROFESSORSHIPS Alexis F. Hartmann, Sr., Lectureship. Established in Several established lectureships enable the School to 1960 by friends interested in pediatrics to provide an bring to the Medical Center each year distinguished annual lecture in Dr. Hartmann's honor. guests who contribute significantly to the richness of Irwin Levy Memorial Fund. Supports the Dr. lrwin c student life. Levy Visiting Lectureship in Neurology, which was estab- Harry Alexander Visiting Professorship. Estab- lished in 1978 by Mr. and Mrs. Meyer Kopolow. lished in 1964 by former house officers and friends of Dr. Oliver H. Lowry Lectureship. Established in 1978 by Harry Alexander to provide an annual visiting professor friends, colleagues, and former students of Dr. Lowry. in the Department of Medicine. Edward Massie Lectureship in Cardiovascular Dis- Alpha Omega Alpha Lectureship. Given each year ease. Established in 1981 by Bernard Shanker, Edward J. by a faculty member of the students' selection. Simon, M.D.,and other grateful colleagues and patients. George H. Bishop Lectureship. Supported by funds H. Re I ton Mc Carroll, Sr., Visiting Professorship in made available by friends interested in the advancement Orthopedic Surgery. Created in 1972 by patients, friends, of neurology. colleagues, and former students in honor of Dr. Estelle Brodman Lectureship Fund. Established in McCarroll. 19X1 by friends and colleagues of Dr. Brodman in honor Carl V. Moore Lectureship. Established in 1973 by of her distinguished contributions to the School of friends and patients of Dr. Carl V. Moore Medicine. Joseph H. Ogura Lectureship. Established in 1977 The James Barrett Brown Visiting Professorship in by friends and colleagues of Dr. Ogura as a tribute to his Plastic and Reconstructive Surgery. Created in 1969 by numerous scientific accomplishments and contributions c patients, friends, colleagues, and former students to honor to the School of Medicine, graduate medical education. Dr. Brown. and commitment to patient care. Thomas H. Burford Lectureship in Thoracic- Rose and Samuel Pollock Surgical Lectureship. Surgery. Founded in 1971 by friends of Dr. Burford. Established in 1976 by Dr. Joseph H. Pollock in memory Glover H. Gopher Lectureship in Cancer. Founded c of his parents. in 1971 with endowment provided by Dr. Copher and friends. Eli Robins Lectureship in Psychiatry. Established in /. Jerome Fiance Visiting Professorship. Established 1977 by friends, colleagues, and former students of Dr. in 1977 by former students and friends of Dr. Fiance to Robins. c provide annually a visiting professor in the Division of Wendell G. Scott Memorial Lectureship. Estab- Pulmonary Diseases. lished in 1972 by friends and colleagues of Dr. Wendell G. Edwin F. Gildea, Jr.. Lectureship in Psychiatry. Scott. Established in 1978 by friends, colleagues, and former Major G. Seelig Lectureship. Established in 1948 in c students of Dr. Gildea. the field of surgery by friends of Dr. and Mrs. Seelig. Joseph J. Gitt Visiting Professorship in Clinical Philip A. Shaffer Lectureship. Founded in 1957 by Neurology. Established in 1971 by his family and friends friends of Dr. Shaffer in recognition of his accomplish- to honor Dr. Gitt. ments in biochemistry. Graham Colloquium. A gift from Mr. and Mrs. St. Louis Football Cardinals Visiting Professorship Evarts Graham, Jr., in 1963 to encourage opportunities in Orthopedic Surgery. Made possible since 1971 by for students to expand their views on social, philosophi- donations from the St. Louis Football Cardinals. cal, artistic, and political topics. c Evarts A. Graham Memorial Lectureship. Estab- Jessie L. Ternberg Pediatric Surgery Visiting Lec- lished in 1959 with a reserve fund left by Dr. Graham for tureship. Made possible from a fund established in 1977 by Mr. Meyer Kopolow to honor Dr. Ternberg. his successors. Evarts A. Graham Visiting Professorship of Sur- Robert J. Terry Lectureship. Established in 1939 by gery. Established in 1968 by the Harry Freund Memorial alumni "for the purpose of fostering greater appreciation Foundation to support an annual lecture in honor of Dr. of the study of human anatomy." Graham's contribution to surgery. Mildred Trotter Lectureship. Established in 1975 by Samuel B. Grant Visiting Professorship. Created in friends and former students of Mildred Trotter to bring a 1963 to provide annually a visiting professor in the distinguished woman scientist to the School of Medicine Department of Medicine. each year. I'I

24 program which allowed undergraduate, graduate and Historical postgraduate students to have meaningful contact with distinguished faculty members in informal small group settings. These tenets have resulted in bringing together a Perspective faculty, staff and alumni who have been awarded 14 The Washington University School of Medicine was Nobel Prizes in physiology and medicine, as well as many established in 1899 as a union of the two oldest medical other honors, appointments and elections to important schools west of the Mississippi River: the Missouri Medi- professional offices. Four faculty members have been cal College, a proprietary school organized and owned by elected to the National Academy of Sciences, six are the faculty, and the St. Louis Medical College, founded by members of the Academy's Institute of Medicine and the local medical society. The Missouri Medical College many more are members of advisory boards of founda- was strong in clinical teaching, while the St. Louis Medi- tions and governmental granting agencies. cal College stressed research, particularly clinical re- Over the years, the Washington University School of search. When the two were united as the Medical Depart- Medicine and its affiliated hospitals have worked and ment of Washington University, they combined these grown together, and in 1962 these several institutions strengths, with the result that today the Washington Uni- formalized their relationships and established what is now versity School of Medicine emphasizes both the scientific termed the Washington University Medical Center. The and research bases of medicine and the application of that Center consists of the Washington University School of knowledge to patient care and clinical practice. Medicine, Barnes Hospital, The Jewish Hospital of St. Reorganized after the famous Flexner Report of Louis, St. Louis Children's Hospital, Barnard Hospital 1912, with the help of the Carnegie Foundation for the and the Central Institute for the Deaf. Integral units of the Advancement of Teaching and funds provided by St. Medical Center include the world-famous Mallinckrodt Louis philanthropist and civic leader Robert Brookings, Institute of Radiology, the Biomedical Computer Center, the School restructured its program, built a new campus and the Irene Walter Johnson Insitute of Rehabilitation. and appointed an entirely new faculty who had been Extensive basic and clinical programs are carried on in trained in the new "scientific" medicine. Among the fea- the various institutions in the Medical Center. In 1981, tures adopted by the reorganized school were: full-time Principal Investigatorships on one or more federal re- teaching appointments, enlarged hospital and outpatient search grants were held by 223 faculty members. Twenty- facilities, laboratory space for both preclinical and clinical five Program Project and Center Grants are held in the departments, faculty time for research, and a teaching fields of cancer, general clinical research, thrombosis,

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The Washington University School of Medicine has a unique full-time faculty system. In 1982 the School employed 694 full-time, salaried faculty members in its eighteen preclinical and clinical departments. The clinical departments are further greatly strengthened by 773 parttime faculty members. The latter group of physicians includes men and women who practice their medical specialties in St. Louis and are members of one or more of the staffs of the six hospitals in the Center. Medical students and resident physicians also receive extensive and valuable clinical training in programs at the St. Louis City Hospital, St. Louis County Hospital and Cochran Veterans Administration Hospital, which are served by full-time and part-time faculty members of the School of Medicine. The student body of the School of Medicine numbers approximately 530 medical students. Programs are also conducted for students in health administration, occupational therapy, physical therapy, radiologic technology and pediatric nurse practice. The Division of t ObtWrte* and aynwqto#fn»»Tn«gii«f • Biology and Biomedical Sciences has extensive graduate training programs for students seeking the Doctor of Philosophy degree in areas of developmental, cellular and systemic biology, evolutionary biology and ecology, molecular biology, neural sciences and plant biology. The diabetes, arthritis, renal diseases, asthma, stroke, glau- outstanding Washington University School of Dental coma, drug abuse, lipid research, emphysema, heart dis- Medicine is adjacent to the School of Medicine. Unaffil- ease, genetics, reproduction, alcoholism, neurobiology iated with Washington University but located close to the and affective disorders. Medical Center is the St. Louis College of Pharmacy. New methods of offering health care have been devel- Each year the School of Medicine and the Washing- oped through such means as the prepaid health mainte- ton University Medical Center Alumni Association, nance organization, the Medical Care Group of St. Louis, through the Division of Continuing Medical Education, which provides comprehensive health care for more than offer many short postgraduate training courses for physi- twenty thousand patients. The Queeny Tower is a multi- cians and other health professionals. These programs purpose building and includes several floors of doctors' provide medical alumni and practicing physicians in St. offices in addition to acute-care and limited-care patient Louis and the Midwest with the opportunity to keep facilities and hotel accommodations for patients under- abreast of rapidly changing medical concepts, informa- going outpatient medical evaluation. The institutions in tion, techniques and treatment. the Medical Center have more than a quarter of a million In summary, the Washington University School of clinic and emergency room visits annually. Patients come Medicine and the several institutions in the Washington to the Center from the metropolitan St. Louis area and University Medical Center are committed to providing the surrounding regions in Missouri and Illinois. Patients patients with high-quality medical care in a concerned, with especially difficult diagnostic and therapeutic prob- compassionate way, to educating superbly qualified lems are referred from throughout the Midwest and young men and women in the health professions, and to beyond. increasing medical knowledge through research.

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the Cancer Research Building, they continue to provide Teaching space for laboratories, offices, the library, and some departmental facilities. West of Euclid Avenue but connected by a pedes- Facilities trian bridge are the major clinical departments of the THE SCHOOL OF MEDICINE School of Medicine, housed in eight buildings. Here the The Washington University School of Medicine and medical school facilities are closely intertwined physically the Medical Center are located along the eastern edge of (and programmatically) with Barnes and Children's Hos- Forest Park in St. Louis. Along the western edge of the pitals. Located here are the following facilities owned and park is the West Campus of the University. A regularly operated by Washington University. scheduled shuttle bus, operated for the benefit of students Edward Mallinckrodt Institute of Radiology, one of and faculty, brings the two campuses within 10 minutes of the largest and best-equipped in the world, houses two each other. Spread over two city blocks, the School of functioning cyclotrons and diagnostic, therapeutic, and Medicine is separated by Euclid Avenue, with preclinical research activities of the Department of Radiology. It is departments predominating on the eastern side. connected on most of its floors with the adjoining Barnes The focal point of teaching facilities is the and Barnard Hospitals, and through them with other McDonnell Medical Sciences Building. The McDonnell hospitals of the group, thus providing easy access for all Building, with 300,000 square feet of the most technologi- inpatients. cally advanced research laboratories and classroom space Renard Hospital, an eight-story structure, is under- in the country, was made possible by James Smith going extensive renovation. With consolidation of patient- McDonnell, a generous benefactor of Washington Uni- care services in the West Pavilion, it will provide addi- I versity. Dedicated in the fall of 1970, it is the center of tional office and laboratory space for the Department of activity for entering medical students. Rising nine floors Psychiatry. above ground, it contains administrative offices and two David P. Wohl, Jr., Memorial Hospital (ten floors) lecture halls on the first floor. Multidisciplinary teaching opened in 1953, and until 1980 housed 80 medical laboratories for first- and second-year students, and patients. A project is under way to renovate Wohl Hospi- offices and research laboratories for the seven existing tal into badly needed research and office space, princi- basic science departments and the Division of Biology pally for the Departments of Medicine and Surgery. and Biomedical Sciences are located on the upper floors. St. Louis Maternity Hospital houses offices and Modern centralized animal quarters are housed in the research laboratories for the Department of Obstetrics basement. and Gynecology. A new Perinatal Center and laborato- The older structures, the North and South Build- ries for research in the physiology of reproduction are ings, in which centered the work of several Nobel located in this building. Laureates, have been extensively renovated. Along with Irene Walter Johnson Institute of Rehabilitation is a center for training personnel in rehabilitation procedures, for treatment of disabled persons in the St. Louis metropolitan area, and for research related to chronic diseases. Oscar Johnson Institute for Medical Research occupies the top five floors of the McMillan Hospital. McMillan Hospital houses offices and research laboratories for the Departments of Neurology and Neurological Surgery, Ophthalmology, and Otolaryn- gology. West Building contains offices and research laboratories for the Department of Preventive Medicine and Public Health, as well as for the Department of Pathology. William Greenleaf Eliot Division of Child Psychia- try, located about a mile from the Medical Center at 367 North Taylor Avenue, conducts an advanced teaching program in child psychiatry and is the focus for research and treatment in child psychiatry.

Biomedical Computer Laboratory An outstanding group of computer scientists, engi- neers and their students are engaged in the development and application of computer technology to biomedical problems.

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The Biomedical Computer Laboratory and the Com- puter Systems Laboratory are located in adjoining buildings at 700 and 724 South Euclid, which also house the Division of Biostatistics of the Department of Preventive Medicine and Public Health. Library The School of Medicine Library is one of the largest medical libraries in the Midwest. It contains a collection of more than 180,000 volumes and subscribes to over 2,000 serials. Special holdings include a rare book collection, the School's historical archives and memorabilia, and manuscript copies of the scientific papers of such outstanding men of medicine as Doctors William Beaumont, Joseph Erlanger, E.V. Cowdry, Evarts Graham and others. A collection of over 400 audiovisual titles is maintained and may be viewed in the Library's Learning Resources Center. The primary purpose of the Library is to provide information, services and materials to the faculty, giving patrons and staff immediate access to information researchers, students and staff of the Medical Center. In about the Library's collection. addition, the Library responds to requests for informa- Computer terminals are available to the public for tion from health professionals throughout the city, state, searching the Library's catalogs of books and journals. and nation, and from local hospitals. It is an active partic- Two terminals are available for computer-assisted instruc- ipant in the seven-state Midcontinental Regional Medical tion, and remote computer data bases (including MED- Library Program under the auspices of the National LINE, Toxline, and Chemical Abstracts) are searched by Library of Medicine. the reference staff on request. The Library is deeply involved in computer research Library hours are 8 a.m. to 12 midnight on week- and use. It runs, at cost, a serials control system days; 8:30 a.m. to 6 p.m. on Saturdays; and 1 p.m. to 10 (PH1LSOM) for a number of medical libraries through- p.m. on Sundays. A student reading room is open 24 out the United States. The Library's cataloging is done in hours a day. In the summer and on holidays, special hours conjunction with the national computer network at the are maintained. Ohio College Library Center (OCLC). Inc., in Columbus. Further information can be found in the "Library The serials, cataloging, and circulation control programs Guide," "Library Notes," and special pamphlets on com- have been combined into an integrated on-line system puter services.

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Facilities Owned by Washington University and Shared University Medical Center consists of a confederation of with Barnes Hospital six strong, private institutions committed to the pursuit of David P. Wohl, Jr., Memorial-Washington Univer- excellence in health care, teaching and research. Students sity Clinics are administered by Barnes Hospital and receive clinical instruction and gain experience in all divi- handle about 150,000 outpatient visits a year. Five floors sions of the Medical Center. of the building are devoted to the Clinics and five floors to Over the past 15 years, with the growing confidence research, including the Division of Health Care Research. of working together, the Washington University Medical This building is owned by the School of Medicine, with all Center has undertaken increasingly complex projects. patient-care services being operated by Barnes Hospital. Evidence of this is the massive redevelopment project under way in the 36-block area surrounding the Medical Center. Working closely with the neighborhood, the THE MEDICAL CENTER, ITS HOSPITALS Washington University Medical Center Redevelopment AND INSTITUTIONS Corporation will, over a nine-year period, provide impe- The School of Medicine is part of a medical center of tus for new office buildings, laboratories, apartment build- nearly 2,000 beds and 11,463 employees, providing nearly ings, commercial areas, renovated single dwellings, and 652,990 days of care and more than 415,000 ambulatory many public improvements. To date, over fifty million care visits each year. Organized formally in 1962, the dollars worth of construction has been completed or umbrella organization now known as the Washington commissioned. i 29 T

Barnes Hospital is the largest hospital in the Medical The combined East-West Pavilion, jointly owned by Center. It is independently owned and, through special Barnes Hospital and the University, is one of the largest, agreement, operates outpatient clinics in buildings owned most sophisticated tertiary medical facilities in the world. by the University. The contiguous facilities provide a A large central diagnostic laboratory provides modern major source of clinical experience for medical students. diagnostic patient services. Barnes Hospital has a capacity of approximately 1,124 Barnard Free Skin and Cancer Hospital is inde- beds, and includes teaching facilities for all clinical depart- pendently owned but is operated by Barnes Hospital. It is ments except Pediatrics. All activities of the School of a 44-bed hospital for the care and treatment of patients Medicine and Barnes Hospital are closely integrated, and who suffer from skin diseases and cancer or who are the hospital staff is composed exclusively of members of undergoing special tests in the Clinical Research Center. the Faculty of Medicine. St. Louis Children's Hospital, governed by its own The eighteen-story Queeny Tower has five nursing directors from its earliest days, has been an integral part of doors and two self-care floors, plus five floors of doctors' the Medical Center and a leader in the development of offices. The addition of four floors to the East Pavilion academic pediatrics. Its professional staff are members of and a companion structure, the entirely new eighteen- the Faculty of Medicine, and the medical director is also story West Pavilion, has resulted in a facility that houses professor and head of the Department of Pediatrics at over 730 patient-care beds, over 50 operating rooms, a Washington University. Considerable clinical service and chronic renal dialysis unit, a 110-seat amphitheatre, doc- research are conducted at Children's. Of particular inter- tors'offices, and additional facilities for the Mallinckrodt est is the recently created Ranken-Jordan Center of Institute of Radiology. Metabolic Diseases.

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Currently, a new Children's Hospital (235 beds) is OTHER INSTITUTIONS under construction approximately one block north of the In addition to the above facilities which make up the present facility. This new building will largely supplant Washington University Medical Center, the following the older facilities and will consolidate a major amount of hospitals are affiliated with the School of Medicine, and pediatric clinical and research activities. various members of the staffs hold University Jewish Hospital of St. Louis contains 595 beds. Its appointments. departments represent each of the major specialties The three City Hospitals: except pediatrics. The Aaron Waldheim Outpatient St. Louis City Hospital, with 464 beds. Clinics provide all facets of health care to the community, Robert Koch Hospital, with 465 beds. while the Yalem Research Building contains important Harry S Truman Restorative Center, with 300 research facilities for the Hospital and School of Medi- beds. cine. The new nine-story Sydney M. Shoenberg pavilion Malcolm Bliss Mental Health Center, with 180 provides inpatient rooms, surgical suites, and facilities for beds. radiology. And soon to be completed is a 400-car addition Ellis Fischel State Cancer Hospital, Columbia. to their parking garage that will span Parkview Place. Missouri, with 113 beds. St. John's Mercy Hospital, with 659 beds. Central Institute for the Deaf a nationally known St. Louis Veterans Administration Hospitals, with institution, provides facilities for research into hearing 947 beds. problems, maintains a school for deaf and speech- St. Louis County Hospital, with 112 beds. handicapped children, provides outpatient clinics for St. Louis Shriners Hospital for Crippled Children, children and adults, and engages in a program of profes- with 80 beds. sional education for scholars in the fields of audiology St. Louis State Hospital, with 625 beds. and otolaryngology. St. Luke's Hospitals, with 559 beds.

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FIRST YEAR Department of Bio 501. Human Anatomy The course is based largely on the dissection of the human body. Lectures on functional and topographic c Anatomy and anatomy emphasize the principles of organization of the various systems of the body. Lectures on developmental Neurobiology anatomy stress organogenesis as an adjunct to understanding the normal and abnormal anatomy. An exten- I The anatomical sciences are presented in three sive museum of labeled dissected specimens is housed in required courses: gross anatomy, offered in the first the dissecting room for ready reference by students who encounter abnormalities or variations in their dissections. semester; and microscopic anatomy and neural science, Frequent use of x-ray films, cineradiography films, fresh taught in the second semester. The course in neural organs, and cross sections aid in the synthesis of knowl- I science is taught conjointly with the Department of Phys- edge gained through dissection into clinically useful iology and Biophysics. In addition, the department offers information. Radiologic anatomy and clinical correlation a series of graduate courses which may be taken as elec- conferences further aid in this process. Occasional tives by senior students. Gross anatomy is taught essen- attendance at autopsies is recommended. Credit 6 units. I tially as a laboratory course, but with some lectures dealing with anatomical principles and with human growth Bio 506. Microscopic Anatomy and development. The course in microscopic anatomy The structure of cells, tissues, and organs is studied with regard to the functional significance of the morpho- consists largely of cell and tissue biology, with laboratory logical features. The laboratories consist of the study of c sessions paralleling the lectures in these areas. Neural prepared slides, of preparations of fresh tissues, and of science is taught mainly from an experimental point of electron micrographs. A microscope will be provided for view, with particular emphasis upon the development and each student. organization of selected neural systems. Throughout all [ three courses, attention is paid to the results of recent Bio 554. Neural Sciences investigations and to major developments in each field. This course, taught conjointly by the Departments of The department is well equipped for special work in Anatomy and Neurobiology and of Physiology and Bio- physics, provides a broad introduction to modern neuro- several areas, including gross anatomy, electron micros- biology. Cellular aspects of neurobiology and a compre- [ copy, tissue culture, neurobiology, cell biology, and hensive overview of the structure and function of major developmental and reproductive biology. systems in the central and peripheral nervous systems. Class time of two half days a week throughout the second semester. A microscope, will be provided for each student. c IVOT' Credit 5 units.

*><£.: c

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RESEARCH Cell growth and radiation effects. (Dr. Tolmach) Bio 590. Research Opportunities Axonal transport. (Dr. Willard) These are offered in the following areas: The structure and function of the cerebral cortex. The cell cycle and cellular differentiation. (Dr. Bischoff) (Dr. Woolsey) The cytology of neural tissue. (Dr. M. Bunge) ELECTIVES I The development of the nervous system and its response The department offers a number of graduate-level to injury. (Dr. R. Bunge) courses which may be taken as electives by medical stu- Anatomy and physiology of the somatosensory system. dents. The department participates in the Division of (Dr Burton) Biology and Biomedical Sciences, which also offers Insulin and growth factor gene organization and expres- courses relevant to anatomy. These course descriptions sion. (Dr. Chirgwin) are presented in the section on Biology and Biomedical Organization and physiology of the retina. (Dr. Cohen) Sciences. Neurogenesis and synapse formation. (Dr. Fischbach) Bio 428. Developmental Neurobiology Growth and differentiation of neuroblastoma and other cultured cell lines. (Dr. Goldstein) Bio 457. Somatosensory System Cell surface glycoproteins. (Dr. C. Gottlieb) Bio 551, 552. Topics in Neurobiology I Cell-cell recognition. (Dr. D. Gottlieb) The structure and function of the cerebral cortex. Bio 561. Topics in Molecular Neurobiology (Dr. Jones) Growth and differentiation of sympathetic neurons in Bio 562. Neural Control of Posture and Movement culture. (Dr. Johnson) '^Central control of blood pressure. (Dr. Loewy) Bio 563, 564. Techniques in Neural Sciences The structure and function of the skin. (Dr. Menton) Cross-sectional anatomy. (Dr. Peterson) The organization of the olfactory system and related parts Note—The number preceding the course title indicates of the basal forebrain. (Dr. Price) that the course is offered by the Division of Biology and Physiology of posture and movement control. Biomedical Sciences and carries credit in the Graduate (Dr. Thach) School of Arts and Sciences.

33 Faculty of the Department of Anatomy and Neurobiology

Edison Professor of Neurobiology and Associate Professors. Thomas A. Woolsey, B.S., University of Head of Department E. Richard Bischoff, A.B., Knox Wisconsin, 1965; M.D., Johns Hopkins Gerald D. Fischbach, A.B., Colgate College, 1960; Ph.D., Washington University, 1969. (See Department of University, 1960; M.D., Cornell University. 1966. Physiology and Biophysics.) University Medical School, 1965. Harold Burton, B.A., University of Assistant Professors Michigan, 1964; Ph.D., University of Professor Emeritus and Lecturer John M. Chirgwin, A.B., Harvard Wisconsin, 1968. (See Department of Mildred Trotter, A.B., Mount Holyoke College, 1968; Ph.D., University of Physiology and Biophysics.) College, 1920; Sc.M., Washington California, Riverside, 1974. Theodore J. Cicero, B.S., Villanova University, 1921; Ph.D., 1924; Sc.D. William A. Frazier, A.B., Johns University, 1964; M.S., Purdue (hon.), Western College, 1956; Sc.D. Hopkins University, 1969; Ph.D., University, 1966; Ph.D., 1968. (See (hon.). Mount Holyoke College, I960; Washington University, 1973. (See Department of Psychiatry.) Sc.D. (hon.) Washington University, Department of Biological Chemistry.) 1980. (See Department of Radiology.) Milton N. Goldstein, B.S., Western Charlene C. Gottlieb, B.A., Radcliffe Reserve University, 1946; M.S., 1947; Beaumont-May Institute of Neurology College, 1966; M.D., Washington Ph.D., 1952. (See Department Scholar in Anatomy and Professor University, 1972. of Pathology.) Richard P. Bunge, B.A., University Mary I. Johnson, B.S., Washington of Wisconsin, 1954; M.S., 1956; Ursula W. Goodenough, A.B., Barnard State University, 1964; M.D., Johns M.D., 1960. College, 1963; M.A., Columbia Hopkins University, 1968. (See University, 1965; Ph.D., Harvard Departments of Neurology and Professors University, 1969. (Also Faculty of Arts Neurological Surgery and Pediatrics.) Mary B. Bunge, B.S.. Simmons College, and Sciences.) 1953; M.S., University of Wisconsin, Elsie S. Rousch, B.S., Madison College. David I. Gottlieb, B.A., State University 1955; Ph.D., I960. 1943; M.S., University of Wisconsin, of New York, Binghamton, 1964; M.A., 1947; Ph.D., Washington University, Adolph I. Cohen, B.S., City College of University of Wisconsin, 1969; Ph.D., 1950. (See Occupational Therapy.) New York, 1948; M.A.. Columbia Washington University, 1971. (See University, 1950; Ph.D., 1954. (See Department of Biological Chemistry.) Clifford B. Saper, B.S., M.S., University Department of Ophthalmology.) of Illinois, 1972; M.D., Washington Boyd K. Hartman, A.B., University of Edward G. Jones, MB., Ch.B., University, 1977; Ph.D., 1977. (See Kansas, 1962; M.D., 1966. (See Department of Neurology.) University of Otago, 1962; Ph.D., Department of Psychiatry.) Oxford University, 1968; M.D., Robert H. Waterston, B.S.E., Princeton University of Otago, 1970. (See Arthur D. Loewy, B.A., Lawrence University, 1965; M.D., University of Department of Neurology and University, 1964; Ph.D., University of Chicago, 1972; Ph.D., 1972. (See Neurological Surgery.) Wisconsin, 1969. Department of Genetics.) Roy R. Peterson, A.B., University of David N. Menton, B.S., Mankato State Research Assistant Professor Kansas, 1948; Ph.D., 1952. College, 1959; Ph.D., Brown University, 1966. (See Department of Pathology.) Steven M. Rothman, M.D., State W. Thomas Thach, Jr., A.B., Princeton University of New York, Upstate, 1973. Joseph L. Price, B.A., University University, 1959; M.D.. Harvard (See Departments of Pediatrics and of the South, 1963; Ph.D., Oxford University, 1964. (See Department of Neurology and Neurological Surgery.) Neurology and Neurological Surgery.) University, 1969. Leonard J. Tolmach, B.S., University Mark B. Willard, B.A. Oberlin Research Instructor of Michigan, 1943; Ph.D., University College, 1965; Ph.D., University of Patrick M. Wood, A.B., Centre College of Chicago, 1951. (See Department Wisconsin, 1971. (See Department of of Kentucky, 1961; M.S., Purdue of Radiology.) Biological Chemistry.) University, 1965; Ph.D., 1968.

34 1 I

An elective in clinical anesthesiology is offered every Department of six weeks for up to six students. The pharmacology of inhalation, intravenous, and local anesthetic drugs is demonstrated by practical application by the student in Anesthesiology the operating room. The importance of blood gas deter- minations in evaluating the efficacy of ventilation is According to the American Board of Anesthesiol- shown. ogy, this specialty may be described as a practice of Opportunities to develop proficiency in techniques medicine which encompasses (1) the management of such as endotracheal intubation are available. Special procedures for rendering a patient insensible to pain dur- sessions on cardiopulmonary resuscitation are conducted ing surgical procedures, (2) the support of life functions and students are expected to attend the regular anesthesia under the stress of anesthetic and surgical manipulations, conferences and seminars. (3) the clinical management of the patient, unconscious from whatever cause, (4) the management of problems in pain relief, (5) the management of problems in cardiac and respiratory resuscitation, (6) the application of specific methods of inhalational therapy, and (7) the clinical management of various fluid, electrolyte, and metabolic disturbances. With these objectives in mind, this department is dedicated to presenting to the student, as opportunities develop, (1) clinical applications of certain anatomic rela- I tionships, e.g., regional nerve blocks, (2) applications of principles of respiratory physiology, e.g., mechanics of ventilation under various circumstances, cardiorespira- tory resuscitation, (3) application of pharmacologic I knowledge related to sedative, narcotic, and anesthetic drugs, and to compounds affecting the autonomic nervous system, (4) clinical problems related to acid-base, fluid, and electrolyte balance in surgical patients, and (5) I principles underlying the approaches to the emerging concept of "acute medicine." After the second year of medical school, preceptorships in anesthesiology are available for eight-week peri- I ods by individual application. Each preceptee is assigned to a staff anesthesiologist and gains experience in the performance of clinical anesthesia, participates in conferences and seminars, and joins in ward rounds in the I recovery room and intensive care unit. I Faculty of the Department of Anesthesiology Professor and A cting Head of Associate Professors Lewis J. Thomas, Jr., B.S., Haverford Department Milton L. Cobb, B.A., Baylor College, 1953; M.D., Washington William D. Owens, B.A., Westminster University, 1964; M.D., University of University, 1957. (See Department of 1 College, 1961; M.D., University of Texas (Southwestern), 1968. (See Physiology and Biophysics and Michigan, 1965. Department of Pediatrics.) Biomedical Computer Laboratory.) James A. Felts, B.S., DePauw Glenn R. Weygandt, B.S., University of Professors University, 1943; M.D., Northwestern Missouri, 1945; M.D., Washington I Leonard W. Fabian, B.S., University of University, 1946. University, 1947. Arkansas, 1950; M.D., 1951. James D. Jones II, B.S., Louisiana Associate Professor (Clinical) Albert Roos, M.D., University of State University, 1940; D.D.S., Loyola Elsie F. Meyers, B.A., Indiana Groningen, 1940. (See Department of University of the South, 1945; M.D., University, 1947; M.D., 1950. Physiology and Biophysics.) University of Alabama, 1957. (See Department of Obstetrics and Assistant Professors Professor (Clinical) Gynecology.) Nabil Abboud, B.A., Christian Brothers C. R. Stephen, B.S., McGill University, A. Ercument Kopman, M.D., Istanbul College, 1963; M.D., St. Joseph's I 1938; M.D.C.M., 1940. University, 1947. University, 1970. (Jewish Hospital.) 1 35 T

Donald J. Dickler, B.A., New York University, 1942; M.D., 1945. (Jewish Hospital.) Gary E. Hirshberg, A.B., Princeton University, 1968; M.D., Hahnemann Medical College, 1972. (See Department of Pediatrics.) James J. Jenkins, HA.. Duke University, 1966; M.D., University of North Carolina, 1970. (Jewish Hospital.) Sara T. Jones, B.A., University of North Carolina, 1958; M.D., Bowman Gray School of Medicine, 1962. Susan W. Krechel, A.B., Washington University, 1967; M.D., University of Louisville, 1972. Palle K. Reddy, M.B.B.S., Kurnool Medical College, 1971. Necita L. Roa, B.S., University of the Philippines, 1964; M.D., 1969. Cyril M. Sliom, M.B., B.Ch., University of Witwatersrand, 1947; F.F.A., South African College of Medicine, 1962. r> (Jewish Hospital.) Instructors Spomenko Bauer, M.D., University of Zagreb Faculty of Medicine, 1968. (Jewish Hospital.) Dushyant N. Bhatt, M.B.B.S., l.okmanya Medical College, 1973. Krishna Chunduri, M.B.B.S., MR. Medical College, Gulbarga, 1974. William J. Gallagher, B.A.. Holy Cross College, 1943; M.D.. Cornell University, 1947. N. R. Gondipalli, M.B.B.S., Kurnool Medical College, 1970. Barry A. Graff, B.A., MacMurray College, 1972; M.D.. St. Louis University, 1976. (Jewish Hospital.) Robert B. Holloway, B.S., LeMoyne College, 1952; M.D., Meharry Medical Madhav Vinjamuri, M.B.B.S.. Medical Paul L. Friedman, A.B., Washington College, 1956. (St. Louis V.A. College of Gulbarga, 1971. University, 1953; M.D., 1957. Hospitals.) Lawrence S. Waldbaum, A.B., Cornell Robert Hellman, B.A., Yeshiva M. Emin Kiyanclar, M.D., Ain-Shams University. 1969; M.D., Washington University, 1969; M.D., New University, 1970. University. 1973. (Jewish Hospital.) Jersey College of Medicine and Ravi S. Kumar, M.B.B.S.. Andhra Instructors (Clinical) Dentistry, 1973. University, 1973. Sedat M. Ayata, B.S., Istanbul George E. Lucas, B.S., John Carroll Silvestre A. Tomeldan, B.S., Far Lyceum. 1949; M.D.. University of University, 1953; M.D., St. Louis Eastern University, 1964; M.D., 1970. Istanbul, 1955. University, 1958. (Jewish Hospital.) Robert C. Engelhardt, B.S., University William A. Sims, Jr., A.B., University of Vijayalakshmi Vallurupalli, M.B.B.S.. of South Carolina, 1946; M.D., Missouri, 1954; B.S.Med., 1955; M.D., Guntur Medical College, 1970. University of Missouri, 1950. Washington University, 1957.

3h I ^ ]

Relationship of enzyme structure and function. Kinetic Department of theory and applications to enzyme reactions. Protein- protein interactions. Polymerization of actin. (Dr. Frieden) Biological Chemistry Cell-cell recognition in normal and malignant cells. Mechanism of cell-wall biosynthesis. (Dr. Glaser) The department offers a general introductory Computer methods in biochemistry and mass spectrome- course, an advanced course relating the subject to biology try. (Dr. Holmes) and medicine, and several specialized courses in the major Biochemical studies of protein-lipid interactions; regula- aspects of biochemistry. Students of medicine and in the tion of blood clotting, and properties of clotting Graduate School of Arts and Sciences may enroll in the proteases. (Dr. Jackson) courses or pursue research work under the direction of Structure of the oligosaccharides of soluble and mem- the staff. Facilities in research are provided in carbohy- brane glycoproteins and their interactions with lectins. drate, lipid, nucleic acid, protein, and steroid biochem- (Dr. R. Kornfeld) istry, and varying emphasis on enzymology, metabolism, physical chemistry, structural studies, or biochemical Nucleic acid biochemistry of eukaryotes. Regulation of transcription during cell differentiation and during viral genetics. Some summer research scholarships are offered oncogenesis. (Dr. Roeder) to students of medicine. Membrane biochemistry of prokaryotes and eukaryotes. (Dr. Silbert) FIRST YEAR Gene structure and protein biosynthesis in eukaryotes. Bio 451. General Biochemistry Cloning, translation and compartmentalization of secre- Involves the basic concepts of biochemistry. Designed tory, mitochondrial and membrane protein. for qualified undergraduate, medical, and graduate stu- (Dr. Strauss) dents. This course or an equivalent course is a prerequisite for advanced courses. Lectures only. Credit 4 units. Bio 531. Advanced Biochemistry A discussion of the biochemistry of organized systems, with special emphasis on problems relevant to medicine. Extensive reading of original literature will be required. The course will consist of four parts: (1) metabolic regulation, including a study of hormonal control; (2) structure and function of membranes and organelle biogenesis; (3) gene expression in higher organisms, including malignant transformation; (4) biochemistry of specialized organs or tissues, for example, connective tissue, bone, blood clotting, etc. Credit 4 units.

RESEARCH Bio 590. Research Opportunities These are offered in the following areas of biochemistry: X-ray analysis of protein structure; structure and mechanism of enzymes, lipoproteins. (Dr. Banaszak) DN A sequence analysis and genetic engineering of bacterial DNA; transcriptional control of bacterial operons. (Dr. Barnes) Structure-function relationships in proteins and enzymes. (Dr. Bradshaw) Biochemical investigation of metabolic disorders of carbohydrate metabolism. (Dr. B. Brown) Studies of pathways of carbohydrate metabolism in mammalian tissues. (Dr. D. Brown) Mechanism of enzyme reactions. (Dr. Drysdale) Studies of mobility on animal cell surfaces and of interactions between surface and cytoskeleton. (Dr. Elson) Structure, function and topography of cell-surface macromolecules responsible for chemotaxis and cell cohesion. (Dr. Frazier)

,17 ¥

ELECTIVES Descriptions of the elective courses are listed under the 9. "frfi&Gi^C&iaPf^iJttrhtoitfL Division of Biology and Biomedical Sciences. In some instances, these courses are offered in alternate years. The faculty member in charge of the course should be con- tacted for specific times. Bio 452. Biochemistry Laboratory

Bio 453. Basic Principles of Nucleic Acids and Protein Synthesis

Bio 537. Protein Chemistry and Enzyme Mechanisms

Bio 538. Structure and Function of Cell Membranes and Surfaces

Bio 5451. Introductory Biophysical Chemistry

Bio 548. Nucleic Acids and Protein Biosynthesis

Faculty of the Department of Biological Chemistry

Professor and Head of Department Elliot L. Elson, B.A., Harvard College, Robert G. Roeder, M.S., University of Luis Glaser, B.A., University of 1959; Ph.D. Stanford University, 1966. Illinois, 1965; Ph.D., University of Toronto, 1953; Ph.D., Washington Carl Frieden, B.A., Carleton Washington, 1969. (See Department University, 1956. College, 1951; Ph.D., University of of Genetics.) Wisconsin, 1955. William R. Sherman, A.B., Columbia Distinguished Service Professor Craig M. Jackson, B.S., Washington University, 1951; Ph.D., University of Emeritus State University, 1963; Ph.D., University Illinois, 1955. (See Department of Carl F. Cori, M.D., University of of Washington, 1967. (See Department Psychiatry.) Prague, 1920; Sc.D. (hon.), Yale of Medicine.) David F. Silbert, A.B., Harvard University, 1946; Sc.D. (hon.). Western Rosalind H. Kornfeld, B.S., George University, 1958; M.D., 1962. Reserve University, 1946; Sc.D. (hon.), Washington University, 1975; Ph.D., Robert E. Thach, A.B., Princeton Boston University, 1948; Sc.D. (hon.), Washington University, 1961. (See University, 1961; Ph.D., Harvard Cambridge University, 1949; Sc.D. Department of Medicine.) University, 1964. (Also Faculty of Arts (hon.), Washington University, 1966. Stuart A. Kornfeld, A.B., Dartmouth and Sciences.) College, 1958; M.D., Washington Joseph J. Volpe, B.A., Bowdoin College, Professors University, 1962. (See Department 1960; M.D., Harvard University, 1964. Leonard J. Banaszak, B.S., University of Medicine.) (See Departments of Neurology and of Wisconsin, 1955; M.S., Loyola Philip W. Majerus, M.D., Washington Neurological Surgery and Pediatrics.) University, 1960; Ph.D., 1961. (See University, 1961. (See Department James C. Warren, A.B., University of Department of Physiology and of Medicine.) Wichita, 1950; M.D., University of Biophysics.) Garland R. Marshall, B.S., California Kansas, 1954; Ph.D., University of Ralph A. Bradshaw, B.A., Colby Institute of Technology, 1962; Ph.D., Nebraska, 1961. (See Department of College, 1962; Ph.D., Duke Rockefeller University, 1966. Obstetrics and Gynecology.) University, 1966. (See Department of Physiology Barbara I. Brown, B.A., Smith College, and Biophysics.) 1946; Ph.D., Yale University, 1950. F. Scott Mathews, B.S., University of Professor (Adjunct) David H. Brown, B.S., California California, 1955; Ph.D., University of Howard A. Schneiderman, B.A., Institute of Technology, 1942; Ph.D., Minnesota, 1959. (See Department of Swarthmore College, 1948; Ph.D., 1948. (See Administration.) Physiology and Biophysics.) Harvard University, 1952. Thomas F. Deuel, A.B., Princeton Blake W. Moore, B.S., University of University, 1957; M.D., Columbia Akron, 1948; Ph.D., Northwestern University, 1961. (See Department University, 1952. (See Department Associate Professors of Medicine.) of Psychiatry.) Oscar P. Chilson, B.S., Arkansas State George R. Drysdale, B.S., Birmingham- William D. Phillips, B.A., University of Teachers College, 1955; M.S., University Southern College, 1948; M.S., Kansas, 1948; Ph.D., Massachusetts of Arkansas, 1958; Ph.D., Florida State University of Wisconsin, 1950; Institute of Technology, 1951. (Also University, 1963. (Also Faculty of Arts Ph.D., 1952. Faculty of Arts and Sciences.) and Sciences.) 38 2 I

William A. Frazier, A.B., Johns Assistant Professors Gregory Grant, B.S., Iowa State I Hopkins University, 1969; Ph.D., Wayne M. Barnes, A.B., University of University, 1971; Ph.D., University of Washington University, 1973. (See California, 1969; Ph.D., University of Wisconsin, 1975. (See Department of Department of Anatomy and Wisconsin, 1974. Medicine.) Neurobiology.) Mark B. Willard, B.A., Oberlin College, William H. Holland, A.B., Washington I David I. Gottlieb, B.A., State University 1965; Ph.D., University of Wisconsin, University, 1950. (See Department of of New York, Binghamton, 1964; M.A.. 1971. (See Department of Anatomy and Psychiatry.) University of Wisconsin, 1969; Ph.D., Neurobiology.) Linda C. Kurz, A.B., Washington Washington University, 1971. (See University, 1967; Ph.D., 1973. Department of Anatomy and Walter L. Nulty, Jr., B.A., Southern I Neurobiology.) Research Assistant Professor Richard Wrenn, B.S., Virginia Polytech Illinois University, 1956. William F. Holmes, A.B., Princeton and State University, 1972; M.S.E.E., University, 1953; Ph.D., University of Washington University, 1975; D.S.C., Lecturer Pennsylvania, 1960. (See Biomedical 1979. (See Electrical Engineering.) I Computer Laboratory.) Walter G. Wiest, A.B., Brigham Young University, 1948; Ph.D., University of John J. Jeffrey, Jr., B.S., College of the Wisconsin, 1952. (See Department of Holy Cross, 1958; Ph.D., Georgetown Instructors Obstetrics and Gynecology.) University, 1965. (See Department Joseph J. Baldassare, B.S., Boston I of Medicine.) College, 1963; Ph.D., University of Arnold W. Strauss, B.A., Stanford Pittsburgh, 1970. University, 1966; M.D., Washington Jens J. Birktoft, Cand. Scient., University, 1970. (See Department University of Copenhagen, I of Pediatrics.) Denmark, 1967. I I I 1 1 1 1 1 1

HH I

FIRST YEAR James S. Bio 550. Medical Genetics Lectures and clinical conferences on human and medical genetics that include population and quantitative McDonnell genetics, clinical cytogenetics, biochemical genetics and metabolic defects, counseling, and immunogenetics. Department of Lectures and clinical conferences only. Credit 2 units. Prerequisite, an introductory genetics course or permis- Genetics sion of the instructor. (Dr. Levine) RESEARCH The James S. McDonnell Department of Genetics Bio 590. Research Opportunities was formed in the fall of 1975 to develop a program of These are offered in the following areas of genetics: prcclinical and graduate instruction in genetics. A medical Mechanisms of gene transposition and plasmid-host cell genetics course in the second semester of the first year is interactions. (Dr. Berg) designed to introduce advanced aspects of human and Genetics of psychiatric disease. (Dr. Cloninger) medical genetics. (Clinical training in genetics is offered in the fourth year by the Division of Medical Genetics of the Molecular-genetic relationships of products of the major Departments of Medicine and Pediatrics.) histocompatibility gene complexes. (Dr. Cullen) The faculty of this new department is currently being Genetics of psychiatric disease, behavioral genetics. recruited. As the department expands, most major areas (Dr. Gottesman) of active genetic investigation and interest will be repre- The genetic and immunologic basis for transplantation sented and a broad, comprehensive program of research reactions. (Dr. Graff) and graduate training opportunities will be developed. Experimental population genetics. (Dr. Hartl) Advanced courses in human genetics and immunoge- Genetic disorders of amino acid metabolism. netics are offered in the second semester. Additional (Dr. Hillman) graduate courses are being developed. Opportunities for Population and biochemical genetics of enzyme research training and experience are available at all levels. polymorphisms. (Dr. Johnson) Genetic specification of membrane structure. (Dr. Levine) Molecular organization of eukaryotic chromosomes. (Dr. Olson) Human population genetics and genetic epidemiology. (Dr. Rao) Genetics of psychiatric disease. (Dr. Reich) Transcriptional regulation of gene expression. (Dr. Roeder) Immunogenetics and biochemical genetics of the major histocompatibility gene complexes. (Dr. Shreffler) Genetics of lysosomal storage disease. (Dr. Sly) Human population genetics. (Dr. Suarez) Population and developmental genetics of parthenoge- netic Drosophila. (Dr. Templeton) Genetics of muscle development in the nematode. (Dr. Waterston) Theoretical population genetics. (Dr. Yokoyama)

ELECTIVE Bio 522. Immunogenetics Genetic and immunologic aspects of variant systems detected by immunologic methods: blood groups, allotypes, histocompatibility antigens. Genetic dissection of immunologic mechanisms. (Dr. Shreffler)

Note—The number preceding the course title indicates that the course carries credit in the Graduate School of Arts and Sciences. 40 I 1

Faculty of the James S. McDonnell Department of Genetics

James S. McDonnell Professor of Associate Professors Research Associate Professor Genetics and Head of Department Douglas E. Berg, B.S., Cornell Daniel E. Dykhuizen, B.S., Stanford Donald C. Shreffler, B.S., University of University, 1964; Ph.D., University of University, 1965; Ph.D., University of Illinois, 1954; M.S., 1958; Ph.D.. Washington, 1969. (See Department of Chicago, 1971. California Institute of Technology, 1962. Microbiology and Immunology.) Assistant Professors Susan E. Cullen, B.S., College of James S. McDonnell Professor of Maynard V. Olson, B.S., California Mount St. Vincent, 1965; Ph.D., Biochemical Genetics Institute of Technology, 1965; Ph.D., Yeshiva University, 1971. Robert G. Roeder, M.S., University of Stanford University, 1970. Illinois, 1965; Ph.D., University of (See Department of Microbiology and Immunology.) Brian K. Suarez, B.A., San Fernando Washington, 1969. (See Department of Valley State College, 1967; M.A., Ralph J. Graff, A.B., Washington Biological Chemistry.) University of California, Los Angeles, University, 1957; M.D., 1957. Professors 1972; Ph.D., 1974. (See Department (See Department of Surgery.) of Psychiatry.) C. Robert Cloninger, B.A., University of (Jewish Hospital.) Texas, 1966; M.D., Washington Shozo Yokoyama, B.S., Miyazaki Dabeeru C. Rao, B.S., Indian Statistical University, 1970. (See Department University, 1968; M.S., Kyushu Institute, 1967; M.S.. 1968; Ph.D., 1971. of Psychiatry.) University, 1971; Ph.D., University of (See Departments of Preventive Washington, 1977. (See Department Irving I. Gottesman, B.S., Illinois Medicine and Public Health and of Psychiatry.) Institute of Technology, 1953; Ph.D., Psychiatry.) University of Minnesota, I960. (See Research Assistant Professors Department of Psychiatry.) Robert H. Waterston, B.S.E., Princeton University, 1965; M.D., University Miroslav Hauptfeld, M.D., University of Daniel L. Hartl, B.S., University of of Chicago, 1972; Ph.D., 1972. Zagreb, 1963. Wisconsin, 1965; Ph.D., 1968. (Also (See Department of Anatomy Vera Hauptfeld, Ph.D., Charles Faculty of Arts and Sciences.) and Neurobiology.) University, 1968. Richard E. Hillman, A.B., Brown University, 1962; M.D., Yale University, 1965. (See Department of Pediatrics.) George B. Johnson, B.A., Dartmouth College, 1964; M.A., 1966; Ph.D., Stanford University, 1972. (Also Faculty of Arts and Sciences.) R. Paul Levine, A.B., University of California, Los Angeles, 1949; Ph.D., 1951. Theodore Reich, B.S., McGill University, 1959; M.D., 1963. (See Department of Psychiatry.) William S. Sly, M.D., St. Louis University, 1957. (See Departments of Medicine and Pediatrics.) Alan R. Templeton, A.B., Washington University, 1969; M.A., University of Michigan. 1972; Ph.D., 1972. (Also Faculty of Arts and Sciences.)

' T [ i c John Milliken Department of c Medicine i The general medicine teaching services of the department are located at Barnes Hospital, Jewish Hospital, and Veterans Hospital (John Cochran Division) under the following directors: Barnes Hospital, Dr. Kipnis House Staff Training Program, Dr. Hammerman Jewish Hospital, Dr. Peck House Staff Training Program, Dr. Lefrak Veterans Hospital, Dr. Chase In addition, for the purposes of both teaching and research, the Department of Medicine is divided into specialty divisions at Barnes Hospital and Jewish Hospital under the following directors: Bone and Mineral Diseases, Dr. Avioli Cardiovascular Diseases, Drs. Sobel, Kleiger Dermatology, Dr. Eisen Endocrinology and Metabolism, Dr. Daughaday Gastroenterology, Drs. Alpers, Stenson Hcmatology-Oncology, Drs. Majerus, S. Kornfeld, T. Deuel Immunology and Allergy Diseases, Dr. C. Parker, Infectious Diseases, Drs. Medoff, Little Laboratory Medicine, Dr. McDonald Medical Genetics, Dr. Sly Pulmonary Diseases, Drs. Pierce, Senior Renal Diseases, Drs. Klahr, Hruska Rheumatology, Dr. Atkinson Instruction in Medicine is provided during all four years of the medical curriculum, beginning with human genetics and an introductory course in the first year. Teaching in the second year has two main objectives: the correlation of the basic sciences with the clinical aspects of disease, and training in the technical methods of physical examination and laboratory diagnosis. By the beginning of the third year, the student is prepared for supervised clinical study of individual patients. A junior clerkship of 12 weeks, divided into two six-week periods, is served on one of the medical services supervised by the department. In the final year, students may elect a subinternship in general medicine or select any of a series of elective courses offered in the various medical subspecialties.

FIRST YEAR Topics in Clinical Medicine This interdepartmental course is designed to stimulate student interest in clinical medicine through carefully selected and presented discussions of both the clinical and basic science features of a number of illnesses. The course director involves faculty from the several clinical departments in structuring the direction, content, and presentation of the subject (Dr. Kipnis and Staff) 42 I SECOND YEAR presented in advance to members of the third- and fourth- Teaching by the Department of Medicine is designed to year classes and to members of the medical staff. At each (1) prepare the student for the transition from the pre- conference the diagnosis is discussed in detail by the clinical sciences to the study of the sick patient at the clinical staff before the anatomical findings are presented bedside, (2) help him analyze the manifestations of disease by the pathologists. (Dr. Kipnis and Medical Staff, in terms of the altered mechanisms responsible for these Dr. Kissane and Pathology Staff) manifestations, and (3) introduce him to the techniques of FOURTH YEAR ELECTIVES examination which are used regularly on all clinical servi- Medical Subinternship ces with the beginning of junior clerkships. This instruc- Medical subinternships, in multiples of six weeks, are tion is at times undertaken jointly with members of other offered to a limited number of students on the following clinical departments, and is coordinated when medical services: Barnes Hospital Blue Service, Jewish practicable with subject matter presented by the Depart- Hospital, St. Louis Veterans Administration Hospital, ment of Pathology. and St. Luke's Hospital. Duties and responsibilities, (a) Pathophysiology including nights on call, will be those of an intern, with the Selected topics in clinical medicine are discussed in proviso that requirements of Missouri state law must be detail to illustrate the application of biochemical, physio- met (e.g., orders must be countersigned by a licensed logical, and anatomical information in the understanding physician, etc.). The workload will be lighter than that for of pathological states. Infectious, cardiovascular and interns to insure ample time for reading about patients. renal, neurological, gastrointestinal, hematological, Instruction and supervision will be provided by the metabolic, nutritional, and developmental diseases are appropriate chief of service, attending physicians, con- reviewed by an interdepartmental faculty. Emphasis is sultants, and house officers. Attendance at scheduled placed on the use of fundamental information in ap- teaching conferences is required. The subinternship proaching clinical problems as a way of thinking in prepa- should be especially valuable to students who plan to take ration for a lifetime of medicine, during which much new straight medical internships and to those who plan to go information will constantly be acquired. directly into a specialty residency program without first (Department of Medicine Staff) serving an internship of any kind (e.g., neurology, psychi- (b) Introduction to Clinical Medicine atry, etc.). (Drs. Chase, Hammerman, The primary goal of Introduction to Clinical Medicine Kipnis, Paine, Peck, and Staff) is to provide a clinical learning experience early in the Clinical Pathological Conference second year where a student begins to become proficient Thursday, 12-1 p.m., September to June. in the collection, communication, and interpretation of (Dr. Kipnis and Medical Staff, patient-related data so that he can participate profitably Dr. Kissane and Pathology Staff) in third-year clinical activities as a member of the health- Arthritic and Rheumatic Diseases care team. This is accomplished by using a variety of (a) Clinical Rheumatology. Barnes, Jewish, and VA, 6 instructional formats including: lectures, demonstrations, weeks, all day. Students will participate in consultative film and videotape, supervised peer examination sessions, service and clinic and inpatient practices. Laboratory clinical subjects, patient simulation, and supervised inter- experience also available. (Dr. Atkinson and Staff) action with patients in both the ambulatory and hospital (b) Research. setting. The understanding of the patient, his interaction 1. Immunogenetics of complement proteins and the with illness, and the importance of a good physician- biochemistry and function of cell surface receptors for patient relationship is emphasized. During the 124 in- immunoglobulins and complement. (Dr. Atkinson) structional hours the mean student/faculty ratio is 5.6:1; in the clinical setting, the student/faculty ratio is 4:1. 2. Students to participate in research procedures (Dr. Tuteur and Staff) which include quantitation of the cell functions of chemotaxis, phagocytosis, and lysosomal enzyme release, isola- THIRD YEAR tion of cell receptors for chemotactic factors and purifica- General Medicine tion of enzymes involved in neutrophil activation. Supervised study of patients on the medical nursing (Dr. Spilberg) divisions of Barnes Hospital (both Blue and Red), Jewish 3. Structure of the human major histocompatibility Hospital, and St. Louis Veterans Administration Hos- complex (H LA) antigens. Mechanisms of HLA and dis- pital. Students are assigned in rotation as clinical clerks to the patients admitted to these services. Teaching is pro- ease associations. (Dr. Schwartz) vided by attending physicians, house officers, consultants, 4. Antigenic specificity and pathogenicity of mono- and at regularly scheduled conferences. Formal instruc- clonal antibodies of DNA are being studied in the mouse tion will be given in medical therapeutics during the models of SLE, as well as alterations of those antibodies junior clerkship. Students serve for six weeks on two of with antiidiotypes. Characteristics of autologous MLR in the five services. (Drs. Chase, Hammerman, SLE patients also under investigation. (Dr. Hahn) Kipnis, Peck, Lefrak, and Staff) Cardiovascular Disease (a) Clinical Pathological Conference (a) Clinical Cardiology. Barnes Hospital, six weeks, all Abstracts of the clinical records of patients upon whom day. Students will participate as members of Cardiovascu- postmortem examinations have been performed are lar Division clinical team, both in the Cardiac Diagnostic

43 5. Myocardial contractile proteins and assessment of metabolism and function in anoxic and ischemic isolated perfused hearts. (Dr. Henry) 6. Hemodynamics, myocardial mechanics, and ven- tricular function (cardiac catheterization). (Dr. Ludbrook) 7. Ultrasonic assessment of cardiac metabolism. (Dr. Perez) 8. Protection of ischemic myocardium in the experimental and clinical setting. (Dr. Roberts) 9. Detection, quantification, and assessment of the mediation of myocardial ischemic injury. (Dr. Sobel)

Dermatology (a) Clinical Clerkship. Students participate in both inpatient and outpatient care. Stress is placed on the dermatologic variations normally encountered, identification of common skin diseases, dermatologic clues to systemic disease, etc. Instruction is given in cutaneous Laboratory and Cardiac Care Unit. Particular emphasis histopathology and clinical mycology. will be placed on clinical diagnosis, electrocardiography (Dr. Eisen and Staff) and the noninvasive techniques. (b) Research. Minimum of 12 weeks, all day. (Dr. Geltman and Staff) 1. Connective tissue, macromolecular organization, degraduation, and related problems. (b) Clinical Cardiology. St. Luke's Hospital, six weeks, (Drs. Bauer, Eisen, Grant, Jeffrey, Seltzer, and Welgus) all day. Students are assigned to Cardiology Division including intensive care unit, heart station, echo labora- 2. Physiology and immunology of pathogenic fungi; molecular basis of morphogenesis and cellular differenti- tory, nuclear cardiology laboratory and catheter labo- ation in Histoplasma capsulatum: host-parasite inter- ratory. (Drs. R. Paine, G. Clark, action and experimental therapeutics in the systemic S. Brodarick and D. Bauwens) mycotic infections. (Dr. Kobayashi) (c) Clinical Cardiology. Jewish Hospital, six weeks, all day. Students have experience in seeing patients in consul- Gastroenterology tation, reading electrocardiograms, and participating in (a) Clinical Gastroenterology. Six weeks, all day. Stu- activities of the Coronary Care Unit and the Graphics dents participate in the study of patients with a spectrum Laboratory. In addition, students may observe proce- of digestive diseases, have responsibility for patients on dures in the cardiac catheterization laboratory. whom consultations have been requested, receive instruc- (I)rs. Kleiger, Krone. Oliver, and Staff) tion in specialized diagnostic techniques, and participate (d) Cardiac Catheterization and Hemodynamics. in the conferences and clinics run by the Division. Highly specialized elective. Six weeks. Students will (Dr. Zuckerman) attend cardiac catheterization procedures and confer- (b) Research. Minimum of 12 weeks, all day. ences; will perform complete "workups" of patients in 1. Clinically applied research on viral hepatitis. preparation for catheterization, etc. Will observe all (Dr. Perrillo) hemodynamic and angiographic procedures. 2. Research on intestinal protein metabolism. (Dr. Ludbrook and Staff) (Dr. Alpers) (e) Electrocardiography. Jewish Hospital. Course 3. Research on lymphocyte function in human designed to give the student familiarity with concepts disease. (Dr. R. MacDermott) involved in the interpretation of electrocardiography. Genetics (Dr. Ruffy) (a) Clinical Genetics. Six weeks, all day. Students par- (0 Research. Minimum of 12 weeks, all day. ticipate in evaluation of patients on whom consultations 1. Lipids in cultured myocardial cells. are requested, receive instructions in interpreting cytoge- (Dr. Ahumada) netics and other specialized laboratory information, and in techniques used in genetic counseling. 2. External assessment of myocardial metabolism and ischemic injury with positron-emitting isotopes. (Drs. Sly and Taysi) (b) Research. Minimum of 12 weeks, all day. (Dr. S. Bergmann) 1. Investigation of inherited amino acid transport 3. Experimental analysis of mechanisms of defects and enzyme replacement therapy and lysosomal arrhythmia. (Dr. Corr) storage diseases. (Dr. Sly) 4. Exercise physiology. (Dr. Ehsani) 2. Chromosome disorders. (Dr. Taysi)

-14 T

Hematology and Oncology (a) Clinical Hematology and Oncology. Six weeks, all day. Students receive intensive instruction in morphology, specialized diagnostic techniques, management of patients with hematologic and oncologic disorders. Two separate clerkships are offered. (Drs. S. Kornfeld, Majerus, Denes) (b) Research. Minimum of 12 weeks, all day. 1. Biochemistry of platelet-vessel wall interactions. Studies focus on mechanism of agonist-activated prosta- cyclin synthesis in cells of vessel wall. (Dr. N. Baenziger) 2. Biochemical studies of poly (adenosine diphospho ribose) synthesis and its role in DNA replication and repair. (Dr. Berger) 3. Biochemistry of platelet release proteins and their relationship to cell growth and inflammation. (Dr. T. Deuel) 4. Studies of neutrophil physiology, cryopreserva- tion of bone marrow stem cells and effector mechanism in tumor immunity. (Dr. Herzig) 5. Biochemistry of mammalian cell membranes. (Drs. R. Kornfeld, S. Kornfeld) Laboratory Medicine 6. Biochemistry of platelets, regulation of lipid (a) Clinical Laboratory Medicine. Proper use of the metabolism in tissue culture; mechanism of platelet laboratory, basic operation of each area, daily activities thrombus formation. (Dr. Majerus) and reading assignments, participation in rounds and 7. DNA sequence amplification in human lympho- conferences. (Dr. McDonald) cytes; molecular biology of synthesis, processing and (b) Research. release of amplified DNA. (Dr. Rogers) 1. Antigens and immunity in human lung carcino- 8. Biochemical studies of interactions of plasma pro- mas. Projects include: detection and analysis of relevant tease inhibitors with coagulation protease. human lung carcinoma plasma membrane antigens using (Dr. Tollefsen) monoclonal antibodies, purification and characterization of these antigens, establishment and application of in Hypertension vitro immunologic assays involving these antigens, analy- Research. Individualized research project and/or par- sis of the immunologic suppression in lung cancer ticipation in a community hypertension program. patients. (Dr. Bell) (Dr. Perry) 2. The possible role of insulin in the regulation of Immunology intracellular calcium homeostasis. (Dr. Chan) Research. Minimum of 12 weeks, all day. 3. Functional and biochemical characterization of 1. Research in areas of experimental immuno- human T lymphocyte subpopulations and identification therapy of murinc lcukcmias or murine models of exper- of human immune response genes. (Dr. Gebel) imental fungal or bacterial infection. (Dr. Little) 4. Rapid diagnostic methods for the detection of 2. The structure and biosynthesis of lymphocyte cell opportunistic systemic fungal infections. surface antigens and lymphocyte triggering mechanisms. (Dr. Kobayashi) The effects of adjuvants in modulating the immune 5. Mechanisms and genetic basis of antimicrobial response. (Dr. Little) resistance in enterococci, drug action and resistance in Infectious Disease Plasmodium falciparum, epidemiology of nosocomial (a) Clinical Infectious Diseases. Study of ward and infection. (Dr. Krogstad) private patients. Barnes Hospital, six weeks, all day. 6. Elaboration of physiological rationale for differ- (Drs. Gelb, Medoff) ences between activity and concentration of electrolytes, (b) Research. particularly calcium. (Dr. Ladenson) 1. Integration-function of oncogenic virus DNA. 7. Development of rapid techniques for recognition Properties/localization of hepatitis B specific nucleic and identification of anaerobic bacteria in body fluids, acids. Properties of varicella-zoster virus DNA and detec- analysis of nutritional requirements of anaerobic bacte- tion in latent infections. (Dr. Gelb) ria, development of standardized susceptibility testing 2. Effective therapy for fungal infections, control of methods for anaerobic bacteria, and in vitro assays of new membrane permeability of fungi, normal and trans- antimicrobial agents. (Dr. Murray) formed animal cells, alteration and control of irnmuno- 8. Mechanism of insulin action at the cellular level logic response to infection and tumors, drug studies on and application of cellular research in diagnosis and bacterial pathogens. (Dr. Medoff) treatment of diabetics. (Dr. McDonald)

45 9. Research elective designed to familiarize student 2. Mechanisms of destruction and synthesis of pul- with fundamental concepts and transplantation immuno- monary connective tissue. (Dr. Senior) logy. (Dr. Rodey) Renal Disease 10. The mechanism of adhesion to and activation of (a) Clinical Nephrology. Barnes Hospital, six weeks, all platelets by collagen and the role of vonWillebrand factor day. Study of patients with renal disease and electrolyte in this process. (Dr. Santoro) disorders. (Drs. Klahr and Slatopolsky) Metabolism and Endocrinology (b) Clinical Nephrology. Jewish Hospital. Students (a) Clinical Clerkship. Students see inpatients and out- will be provided opportunity to evaluate patients on the patients with endocrine and metabolic disease and partic- renal consultant service, participate in daily clinical neph- ipate in the rounds and conferences of the Metabolism rology rounds, and participate in combined rounds. Division. (Drs. Avioli, Daughaday, and Staff) (Dr. Hruska) (b) Bone and Mineral Metabolism. Jewish Hospital. (c) Mixed clinical and research electives. Designed to acquaint student with clinical, radiological, 1. Micropuncture of superficial and deep nephrons and pathological manifestations of generalized disorders and the physiology of urinary acidification. of the skeleton and to expose him to current concepts of (Dr. Buerkert) therapy. (Drs. Avioli, S. Birge, Chase, 2. Studies on the physiological and metabolic effects T. Hahn, Teitelbaum, and Whyte) of chronic ambulatory peritoneal dialysis in patients with (c) Research. Minimum of 12 weeks, all day. end-stage renal disease. (Dr. Delmez) 1. Mineral homeostasis: calcitonin, parathyroid and 3. Effects of phosphate depletion on glucose utiliza- vitamin D. (Drs. Avioli, Birge, Chase, Hahn) tion, effects of PTH on carbohydrate intolerance of 2. Pituitary physiology; growth hormone, prolactin. uremia, effects of PTH and phosphate depletion on peri- (Dr. Daughaday) pheral glucose utilization, effect of uremia and dialysis on 3. Polypeptide hormone receptors in endocrine plasma catecholamine levels and gastrointestinal abnor- research; theoretical background developed. Radio- malities associated with chronic renal disease, hemodialy- receptor assay experience provided and clinical applica- sis and renal transplantation. (Dr. Harter) tions of assays will be emphasized. (Dr. Gavin) 4. Cellular mechanisms of parathyroid hormone 4. The pathophysiology of hypercholesterolemias. action. Renal phospholipid metabolism and effects of Cultured human skin fibroblasts and arterial endothelial parathyroid hormone. (Dr. Hruska) and smooth muscle cells are used to study the interaction 5. Methodology of ion transport and principles of of lipoproteins with tissues in well-defined familial hyper- energy transfer and ion transfer. Studies on the mecha- cholesterolemias. Relationship of contractile proteins to nisms of renal injury in urinary tract obstruction. hormone secretion. (Dr. Ostlund) (Dr. Klahr) 5. Studies of the insulin gene and regulation of 6. Studies on the metabolism of parathyroid hor- insulin gene expression in human diabetes and experi- mone by isolated adult perfused bone. Studies on the mental animals. (Dr. Permutt) cellular mode of action of parathyroid hormone. Pharmacology / Medicine (Dr. K. Martin) Biologic effects of oxygenated fatty acids metabolites 7. Role of chemotaxis in osteoclast recruitment and on renal function. (Dr. Morrison) the pathophysiology of renal osteodystrophy, cellular Pulmonary Disease and Function control of osteoclast function, effects of vitamin D ana- (a) Medical Aspects of Pulmonary Disease. A full-time logues, calcitonin and PTH on osteoclast. (Dr. Malone) elective, periods one through eight. Elective offered at 8. Studies on the biochemical control of parathyroid both Barnes and Cochran V.A. Hospital. hormone synthesis and release. (Dr. Morrisey) (Drs. Pierce, Tuteur and Staff) 9. Structural-functional correlations in renal disease. (b) Pulmonary Medicine. Six weeks. Students will Methodology used in transmission and scanning electron work up patients and participate in teaching conferences microscopy. (Dr. Purkerson) and work rounds, Jewish Hospital. 10. Radioimmunoassay for parathyroid hormone. (Dr. Senior and Staff) Role of the liver in the metabolism of parathyroid hor- (c) A full-time elective in Intensive Care Medicine mone. Studies investigate interrelationships between offered in the MICU at Jewish Hospital, periods one vitamin D metabolites and parathyroid metabolism. through eight. (Dr. Senior and Staff) (Dr. Slatopolsky) (d) A full-time elective in intensive care medicine 11. Studies of solute transport in isolated membrane offered in the MICU and R1CU at Barnes Hospital vesicles from renal tubular cells. (Dr. Schuster and Staff) (Drs. Hammerman and Cohn) (e) Research 1. Clinical research in various aspects of chronic obstructive pulmonary disease. (Dr. Pierce)

4h I

Faculty of the John Milliken Department of Medicine

Adolphus II IIsell Professor and M. Kenton King, B.A., University of John A. Pierce, M.D., University of Chairman of Department Oklahoma, 1947; M.D., Vanderbilt Arkansas, 1948. David M. Kipnis, A.B., Johns Hopkins University, 1951. (See Administration Glenn E. Rodey, B.S., Ohio University, University, 1945; M.A., 1949; M.D., and Department of Preventive Medicine 1957; M.D., Ohio State University, 1961. University of Maryland, 1951. and Public Health.) (See Department of Pathology.) John E. and Adaline Simon Saulo Klahr, B.S., College of Santa David Schlessinger (Microbiology), Professor and Associate Chairman Librada, 1954; M.D., Universidad B.A., University of Chicago, 1955; B.S., of Department Nacional de Colombia, 1959. 1957; Ph.D., Harvard University, 1960. William A. Peck, A.B., Harvard Robert E. Kleiger, B.A.. Yale University, (See Department of Microbiology and University, 1955: M.D., University of 1956; M.D., Harvard University, 1960. Immunology.) Rochester, 1960. George S. Kobayashi (Microbiology), Gustav Schonfeld, A.B., Washington Sydney M. and Stella H. Shoenberg B.S., University of California, 1952; University, 1956; M.D.. 1960. (See Professor Ph.D., Tulane University, 1963. (See Department of Preventive Medicine and Department of Microbiology and Public Health.) Louis V. Avioli, B.A., Princeton Immunology.) University, 1953; M.D., Yale Robert M. Senior, A.B.. Oberlin University, 1957. Rosalind H. Kornfeld, B.S., George College, 1957; M.D., George Washington University, 1957; Ph.D., Washington University. 1961. Professors Emeriti Washington University, 1961. (See Robert E. Shank, A.B., Westminster Carl G. Harford, A.B., Amherst Department of Biological Chemistry.) College, 1935; M.D., Washington College, 1928; M.D.. Washington Stuart A. Kornfeld, A.B., Dartmouth University, 1939. (See Department of University. 1933. (See Medical College, 1958; M.D., Washington Preventive Medicine and Public Care Group.) University, 1962. (See Department of Health.) Virginia Minnich, B.S., Ohio State Biological Chemistry.) Laurence A. Sherman, B.A., B.S., University, 1937; M.S., Iowa State J. Russell Little, Jr., A.B., Cornell University of Chicago, 1956; M.D., College, 1938. University, 1952; M.D., University of Albany Medical College, 1964. (See Edward H. Reinhard, A.B., Washington Rochester, 1956. (See Department of Department of Pathology.) University, 1935; M.D., 1939. (See Microbiology and Immunology.) Eduardo Slatopolsky, M.D., University Department of Radiology.) Philip W. Majerus, M.D., Washington of Buenos Aires, 1959. Professors University, 1961. (See Department of William S. Sly, M.D., St. Louis David H. Alpers, A.B., Harvard Biological Chemistry.) University, 1957. (See Departments of University, 1956; M.D., 1960. Gerald Medoff, A.B., Columbia Genetics and Pediatrics.) Elmer B. Brown, Jr., A.B.. Oberlin College, 1958; M.D., Washington Burton E. Sobel, A.B.. Cornell College, 1946: M.D., Washington University, 1962. (See Department of University 1958; M.D., Harvard University, 1950. (See Administration.) Microbiology and Immunology.) University. 1962. Hugh Chaplin, Jr., A.B., Princeton Charles W. Parker (Howard Hughes John D. Vavra, B.A., University of University, 1943; M.D., Columbia Medical Institute Investigator in Colorado, 1950; M.D., Washington University, 1947. (See Department Medicine), M.D., Washington University, 1954. (See Administration of Preventive Medicine and University, 1953. (See Department of and Department of Preventive Medicine Public Health.) Microbiology and Immunology.) and Public Health.) Philip E. Cryer, B.A., Northwestern H. Mitchell Perry, M.D., Washington R. Dean Wochner, A.B., Arizona University. 1962; M.D., 1965. (Also University, 1946. State University, 1956; M.D., Clinical Research Center.) Washington University, 1960. (See William H. Danforth, A.B., Princeton Department of Preventive Medicine and University, 1947; M.D., Harvard Public Health.) University, 1951. (See Administration.) Professor (Adjunct) William H. Daughaday, A.B., Harvard University, 1940; M.D., 1943. Robert M. Donati, B.A., St. Louis University, 1955; M.D., 1959. (Chief of Thomas F. Deuel, A.B., Princeton Staff, Veterans Administration University, 1957; M.D., Columbia Hospital.) University, 1961. (See Department of Biological Chemistry.) Research Professor Arthur Z. Eisen (Dermatology), A.B., Irene E. Karl, B.S., University of University of Buffalo, 1951; Sc.M., Wisconsin, 1937; M.A., 1938; Brown University, 1953; M.D., Ph.D., 1940. University of Pennsylvania, 1957. John J. Jeffrey, Jr. (Dermatology), B.S., Professors Emeriti (Clinical) College of the Holy Cross, 1958; Ph.D., Clinton W. Lane (Dermatology), A.B., Georgetown University, 1965. (See St. Mary's College, 1916; M.D., St. Department of Biological Chemistry.) Louis University, 1921.

47 7

K.dward Massie, All., Washington Lawrence D. Gelb, B.S., University of Benjamin D. Schwartz (Howard University, 1931; M.D., 1935. Michigan, 1963; M.D., Harvard Hughes Medical Institute Investigator University, 1967. (See Department of in Medicine), B.A., Columbia College, Microbiology and Immunology.) 1965; Ph.D.. Albert Einstein College Professors (( linical) Samuel B. Guze, M.D., Washington of Medicine, 1971; M.D., 1972. I. J. Fiance, AH.. Washington University, 1945. (See Administration (See Department of Microbiology University, 1931; M.D.. 19.15. and Department of Psychiatry.) and Immunology.) Bernard T. Garfinkel, Ml), Bevra II. Hahn, B.Sc,, Ohio State Barry A. Siegel, A.B.. Washington Washington University, 1948. University, I960; M.D.. Johns Hopkins University. 1965; M.D., 1969. (See Kalph V. Gicselman, M.I).. Washington University, 1964. Department of Radiology.) University, 1947. Theodore J. Hahn, Jr., A.B., Princeton Isaias Spilberg, B.S., University of San Michael M. Karl, U.S.. University of University, I960; M.D..Johns Hopkins Marcos, 1956; M.D., 1963. Wisconsin. 1936; M.D., University of University, 1964. Peter G. Tuteur (Robert Wood Johnson I oinsville, 1938, Ilerschel R. Ilarter, B.S., Marquette Health Policy Fellow in Medicine), Virgil Loeb, Jr., M.I).. Washington I imcisitv. 1962; M.D . Georgetown A.B., Johns Hopkins University, 1962; University, 1944. University, 1966. M.D., University of Illinois, 1966. (J. Charles Oliver, AH.. Harvard Philip D. Henry, M.D.. University of H. James Wedner, A.B., Cornell University, 1953; M.D., 1957. Berne, I960. University, 1963; M.D., 1967. Kohert I'ainc, M.I)., Harvard Geoffrey P. Herzig (Leukemia Society Research Associate Professors University, 1944. of America Scholar in Medicine), B.S., Norma A. Fletcher, M.S., Technical Fran/ V. Steinberg, M.D.. University of University of Cincinnati. 1963; M.D., University, 1949; Ph.D., University of Heine. 1938. (See Departments of Western Reserve University, 1967. Copenhagen, 1965. Preventive Medicine and Public Health Craig M. Jackson, B.S., Washington James G. Miller, A.B., St. Louis .mil Surgcrv I State University. 1963; Ph.D., University University, 1964; M.A., Washington of Washington, 1967. (See Department University, 1966; Ph.D., 1969. (See of Biological Chemistry.) Biomedical Computer Laboratory.) A ssociate Professors Ronald Krone (John E. Simon Scholar (Also Faculty of Arts and Sciences.) John 1*. Atkinson (Howard Hughes in Medicine), M.D., University of Associate Professors Emeriti (Clinical) Medical Institute Investigator in Chicago, 1966. Medicine), A.B., University of Kansas, James W. Bagby (Dermatology), 1965; Ml).. 1969. (See Department of Stephen S. I.efrak, A.B., Colgate A.B., University of Missouri, 1930; University. I960; M.D.. State University Microbiology and Immunology.) B.S.Mcd., 1931; M.D., Washington of New York, Downstate. 1965. F.ugene A. Bauer (Dermatology). University, 1933. U.S.. Northwestern University. 1963; David M. I.ieberman, M.D., Vanderbilt Paul 0. Hagemann, A.B., Washington M.D.. 1967. University, 1949 University, 1930; M.D., 1934. ( . Klliott Bell, Jr., B.S.. Tulanc Philip A. I.udbrook, MB., B.S., Stanley F. Hampton, A.B.. Washington University, I960; M.D.. 1964.(See University of Adelaide. 1963. (See and Lee University, 1930; M.D., Department of Pathology) IX-partment of Radiology.) Washington University, 1934. Nathan A. Berger(l cukcmia Society of Jay M. McDonald, B.S.. Tufts Morris D. Marcus (Dermatology), America Scholar in Medicine), A.B., University. 1965; M.D.. Wayne State M.D.. Washington University, 1934. University, 1969. (See Department of lemple University. 1962; M.D., Harold Scheff, M.D., University of Hahnemann Medical College, 1966. Pathology.) (Director of Diagnostic Laboratories, Barnes Hospital.) Toronto, 1931. Stanley J. Birge, Jr.. B.A., Amherst Associate Professors (Clinical) College, 1959; M.D.. Washington William V. Miller (Visiting Staff). A.B., Jack Barrow, M.D., Washington University. 1963. University of Missouri. 1962; M.D.. 1966. (See Department of Pathology.) University, 1946. lewis R. Chase, A.B.. Princeton Morton A. Binder, B.S., Yale University. I960; M.D.. Harvard Richard K. Ostlund, Jr., B.S.. University University, 1948; M.D., Columbia University. 1964. (Chief. Washington of Utah. 1966: M.D.. 1970 University, 1951. University Medical Service. C'ochran Marshall A. Permutt, A.B., Johns V.A. Hospital.) Hopkins University. 1961; M.D., Arnold Dankner, M.D., Washington University, 1947. David N. Diet/ler (Clinical Chemistry), Washington University, 1965. \ H . Washington University, 1957; Mabel I.. Purkerson, A.B., Erskine John J. Garrett, M.D.. Harvard Ph.D.. 1963. (Sec IVpartment of College. 1951; M.D.. Medical College University, 1951. (See Medical Palhologv ) of South Carolina. 1956. (See Care Group.) AU A. Ehsani, M.D.. Tehran University. Administration and Department Neville Grant, A.B., Yale University. 1965 (See I\-partmen( of Preventive of Pediatrics.) 1950: M.D.. Columbia University, 1954. Medicine and Public Health and Irene Robert Roberts, B.Sc. Memorial James N. Heins. A.B.. University of Waltci Johnson Institute of University, 1961; M.D., Dalhousie Louisville. 1957; M.D., 1961. Rehabilitation.) University. 1965. Harold J. Joseph, B.A.. University of Anthony P. Fletcher. B.M.. John C. Rogers, B.S.. University of Texas, 1947; M.D.. 1950. University of London. 1943; B.S.. 1943; Nebraska. 1966; M.S.. 1968: Owen S. Kantor, M.D.. University of M.D .. 1949. M.D.. 1968. Missouri. 1968.

4S I Robert S. Karsh, A.B., Washington Assistant Professors Edward M. Geltman, B.S.. University, 1951; M.D., 1952. Gail A. Ahumada, B.A., Stanford Massachusetts Institute of Technology, Charles Kilo, M.D., Washington University, 1961; M.A., 1962; M.D., 1967; M.D., New York University, 1971. University, 1959. University of California, (See Department of Radiology.) Philip E. Korenblat, M.D., University of San Diego, 1972. Stephen J. Giddings, A.B., Dartmouth Arkansas, 1960. Elsa Bello-Reuss, B.A., University College, 1968; Ph.D.. 1973; M.D., Marvin E. Levin, A.B., Washington of Chile. 1957; M.D., 1964. (See University of Rochester, 1976. University, 1947; M.D., 1951. Department of Physiology and Andrew P. Goldberg, B.A., Clark Biophysics.) Joseph Levitt, M.D., Washington University, 1965; M.D., State University University, 1949. Steven R. Bergmann (Medical of New York, Downstate, 1969. (See Physiology), B.A., George Washington Department of Preventive Medicine and David M. Lieberman, M.D., Vanderbilt University, 1972; Ph.D., Hahnemann Public Health.) University, 1949. Medical College, 1977. Boas Gonen, B.S., Hebrew University, Harvey Liebhaber, A.B., New York Dennis M. Bier, B.S., LeMoyne College, 1966; M.D., 1973. (See Department of University, 1953; M.D., 1957. 1962; M.D., New Jersey College of Preventive Medicine.) Herbert Lubowitz, A.B., Clark Medicine, 1966. (See Department Jeffrey I. Gordon, John A. and George University, 1954; M.D., Washington of Pediatrics.) L. Hartford Fellow in Medicine University, 1958. George J. Broze, Jr., B.S., University of (Gastroenterology), A.B., Oberlin Edward J. Miller, B.A., St. Johns Washington, 1968; M.D., Washington College, 1969; M.D., University of University, 1958; M.D., St. Louis University, 1972. Chicago, 1973. University, 1962. John E. Buerkert, B.S., University of Guner B. Gulmen. M.D., Hacettepe James F. Nickel, A.B., University of San Francisco, 1963; M.D., Marquette University, 1969. (See Medical Oklahoma, 1944; M.D., Washington University, 1968. Care Group.) University. 1948. Marc R. Hammerman, A.B., Michael E. Cain, B.A., Gettysburg Washington University, 1969; Robert C. Packman, A.B., Washington College, 1971; M.D., George M.D., 1972. University, 1953; B.S.Med., University Washington University, 1975. of Missouri, 1954; M.D., Washington Scot G. Hickman, A.B., Duke Edward J. Campbell, B.S., Purdue University, 1956. University, 1966; M.D., Washington University, 1969; M.D., Washington University, 1970. Mary L. Parker, B.S., Florida State University, 1972. University, 1946; M.S., 1949; M.D., John O. Holloszy, M.D., Washington Washington University, 1953. (See Kwok-Ming Chan, Ph.D., University of University, 1957. (See Department of Department of Preventive Medicine South Dakota, 1977. (See Department Preventive Medicine and Public and Public Health.) (University of Pathology.) Health.) Health Service.) Joan G. Clark, B.A., University of Keith A. Hruska, Established William D. Perry, A.B., Northwest Minnesota. 1970; M.D., Washington Investigator of the American Heart Missouri State College, 1943; B.S.Med., University, 1974. Association; B.S., Creighton University, University of Missouri, 1945; M.D., William E. Clutter, B.S., Ohio State 1965; M.D., 1969. Washington University, 1947. University, 1972; M.D., 1975. (Also Allan S. Jaffe, B.S., University of Ernest T. Rouse, B.S., Alabama Clinical Research Center.) Maryland, 1968; M.D., 1973. Polytechnic Institute, 1939; M.D., Peter B. Corr (Pharmacology), Donald K. King, A.B.. Fairfield Washington University, 1943. Established Investigator of the University, 1966; M.D., Johns Hopkins Shabbir H. Safdar, F.Sc, Government American Heart Association; B.S., University, 1970. (See Medical College Jhang, 1954; M.D., Nishtar Union University, 1971; Ph.D., Care Group.) Medical College, 1961. Georgetown University, 1975. (See Donald J. Krogstad, A.B., Bowdoin Llewellyn Sale, Jr., A.B., Yale Department of Pharmacology.) College, 1965; M.D., Harvard University, 1936; M.D., Washington Carlos C. Daughaday, A.B., Harvard University, 1969. (See Department of University, 1940. University, 1967; M.D., Washington Pathology.) (Director of Microbiology Laboratory, Barnes Hospital.) Burton A. Shatz, A.B., Washington University, 1971. Anthony Kulczycki, Jr., A.B., Princeton University, 1940; M.D., 1943. James A. Delmez, A.B., Washington University, 1966; M.D., Harvard University, 1969; M.D., University of James C. Sisk (Dermatology), University, 1970. (See Department of Rochester, 1973. A.B., Washington University, 1943; Microbiology and Immunology.) M.D., 1946. Seth A. Eisen, B.A., Reed College, 1962; Jack H. Ladenson (Clinical Chemistry), Ross B. Sommer, A.B., Miami M.D., Washington University, 1966. B.S., Pennsylvania State University, University, 1949; M.D., Cornell James R. Gavin III, B.S., Livingstone 1964; Ph.D., University of Maryland, University, 1949. College, 1966; Ph.D., Emory University, 1971. (See Department of Pathology.) J. Allen Thiel, B.S., Rockhurst College, 1970; M.D., Duke University, 1975. Louis G. Lange III, A.B., University of 1956; M.D., St. Louis University, I960. Howard M. Gebel (Clinical Rochester, 1970; M.D., Harvard Stanley M. Wald, M.D., Washington Immunology), B.S., University of University, 1976; Ph.D., 1976. University, 1946. Illinois, 1973; Ph.D., University of Kenneth M. Ludmerer, A.B., Harvard Alvin S. Wenneker, A.B., Washington Missouri, 1976. (See Department University, 1968; M.A., Johns Hopkins University, 1949; M.D., 1953. of Pathology.) University, 1971; M.D., 1973.

4') I I

Hlchard P. MacDermott, B.A., Obcrlin Barry A. Siegfried, B.S., Washington Ida K. Mariz, A.B., Washington College, 1965; M.D., Ohio State University, 1972; M.D., 1976. University, 1940. I University, 1969. I.ouis Simchowitz, B.S., City College of Dwight E. Matthews, B.A., DePauw John D. G. Malone, IRC I'. SI. New York, 1966; M.D., New York University, 1973; Ph.D., Indiana Royal College of Surgeons, 1967. University, 1970. University, 1977. Hlchard B. Markham, A.B., Harvard William F. Stenson, B.A.. Providence Robert P. Mecham, B.S., University I University, 1969; M.D., Albert Einstein College, 1967; M.D., Washington of Utah, 1973; Ph.D., Boston College of Medicine, 1972. University, 1971. University. 1976. Kevin J. Martin, MB., B.Ch., B.A.O., Robert J. Stine, B.A., Williams College, Jeremiah J. Morrissey, B.A., University College ol Dublin, 1971. 1964; M.A.T., Harvard University, 1965; MacMurray College, 1969; Ph.D., St. M.D., Vanderbilt University, 1972. (See Louis University, 1974. 'l John A. McDonald, B.A., University of South Florida, 1965; M.S., 1967; Ph.D., Department of Surgery.) Theodore W. Munns, B.S., Bradley Rice University, 1970; M.D., Duke Kongsak Tanphaichitr, M.D.. Siriraj University, 1963; Ph.D., St. Louis University, 1973. Hospital Medical School, 1970. (See University, 1970. Robert C. McKnight, B.S., Florida Medical Care Group.) Bellur Seethuram, B.S., Mysor State University, 1957; M.D., Alan J. Tiefenbrunn, A.B., Washington University, 1961; M.S., Bangalore Washington University, 1961. (See University, 1970; M.D., 1974. University, 1965; Ph.D., 1972. Department ol Radiology.) Douglas M. Tollefsen, B.A., Grinnell Jo L. Seltzer (Dermatology), A.B., Victor N. Mclt/ri, B.S., Northwestern College, 1970; M.D., Washington Washington University, 1963; University 1973; M.D., 1975. University, 1977; Ph.D., 1977. Ph.D., 1969. Stanley Mogelson, A.B., Washington Howard G. Welgus (Dermatology). Assistant Professors Emeriti (Clinical) University, 1970; B.M.S., Dartmouth B.A.. Rice University, 1973; M.D.. Joseph C. Edwards, A.B., University of College, 1972; M.D.. Washington Washington University, 1977. Oklahoma, 1930; M.D., Harvard University, 1974. Michael P. Whyte, B.A., New York University, 1934. Aubrey R. Morrison, Established University. 1968; M.D.. State University Samuel B. Grant, B.S., Washington Investigator ol the American Heart of New York. Downstate, 1972. University. 1918; M.D., 1920. Association; MB.. B.S., University of George D. Wilner, B.S.. Northwestern M. Norman Orgel, B.S., College of the London, 1970 (See Department of University, 1962; M.D., 1965. (See City of New York, 1929; M.A., Harvard Pharmacology.) Department of Pathology.) University, 1930; M.D., Washington Patrick R. Murray, B.S.. St. Mary's Gary R. Zuckerman, B.S., St. Louis University, 1934. College, 1969; Ph.D., University of College of Pharmacy. 1958; D.O., Barrett L. Taussig, A.B., Harvard California, 1974. (See IX'purtmcnt Kansas City College of Osteopathic ol Pathology.) College. 1928; M.D., Washington Medicine. 1963. University, 1932. Moon II. Nahm, A.B.. Washington Research Assistant Professors University, 1970; M.D.. 1974. (See Keith S. Wilson, A.B., Williams College. Department ol Pathology ) Joseph J. H. Ackerman (Chemistry). 1930; M.D.. Washington University, 1934. B.A., Boston University, 1971; Ph.D.. Assistant Professors (Clinical) Wolfgang P. Th. Patsch, Ml)., Colorado State University. 1977. University ol Innsbruck, 1971. Charles C. Abel, A.B., Westminster Thomas W. Allen (Education), B.A., Julio E. Perez, H S . Uni\crsil\ ol College, 1952; M.D., Washington Cornell College, I960; Ed.D.. Harvard University, 1956. Puerto Rico, 1970; Ml)., 1973. University, 1966. Robert P. Pcrrillo. B.S., lordham Nancy L, Baenziger, B.A.. St. Olal E University, 1966; M.I).. Georgetown College. 1967; Ph.D.. Washington University, 1970. University. 1971. Cordon I.. Phillips II. B.A.. University .luiiiii.i M. Brajtburg, M.S.. University ol Oklahoma. 1966; M.D.. 1971. (Sec of Lodz. 1950; Ph.D., 1968. Department of Radiology ) Edwin B. E'isher, Jr. (Psychology). B.A.. Alan M. Robson, M.B.B.S.. Univeisitv Amherst College. 1968; Ph.D.. State ol Durham. 1959; Ml).. 1964. (See University of New York. 1972. Department of Pediatrics.) Rodolphe RufTy, M.D.. University ol Gregory A. (.runt (Dermatology). B.S., I ausannc. 1968 Iowa State University. 1971; Ph.D., Julio V. Santiago. B S . Manhattan University of Wisconsin. 1975. (Sec Department of Biological Chemistry.) College. 1963; M.D., Universit) ol Puerto Rico. 1967. (Sec Department Bam R. Hieb. B.A.. Bethel College. ol Pediatrics.) 1966; M.D.. Washington Samuel A. Santoro, B S . Emoiy University. 1970. University, 1972; M.D., Vhnderbilt Jung S. Huang. B Ph.. Kaohsiung University, 1979; Ph.D.. 1979. (Sec Medical College. 1966; M.S.. National Department of Pathology.) Taiwan University. 1968; Ph.D.. 1972. Helen M. Shields, H.A., Mount Buddhiraju V. Kumar, B.S.. Osmania Hotyoke College, 1967; M.D.. Tufts University, 1963; M.S.. 1965; Ph.D.. University. 1971. 1972 50 1 I I

Oliver Abel III, A.B., Westminster Siddhesh Gowda, MB., B.S.. Medical J. Roger Nelson, A.B.. Washington I College, 1951; M.D., Washington College Bellary Mysore. 1969. (See University. 1949; M.D., 1953. University, 1955. Department of Radiology.) Leonard N. Newmark, A.B., Morris Alex, B.S., University of John M. Grant, A.B., Princeton Washington University, 1956; A.M., Missouri, 1942; M.D., Washington University, 1950; M.D., Washington 1959; M.D., 1963. I University. 1943. University. 1954. Gordon Newton, M.D., University of France Alexander, A.B., Indiana William K. Hall (Dermatology), B.S., Arkansas, 1958. University, 1950; M.D., 1953. Yale University, 1939; M.D., Harvard Scott M. Nordlicht, B.A., Columbia Om P. Bahl, M.B.B.S., Punjab University, 1942. University, 1969; M.D., State University University, 1957; M.R.C.P., University David T. Hammond, A.B.. Indiana of New York. Downstate, 1973. of Edinburgh, I960. University. 1957; M.D., Washington Charles C. Norland, B.S.. Washington Robert W. Barton, B.S., University of University, I960. State University. 1955: M.D.. Chicago, 1962; M.D.-Ph.D., 1967. Bernard Hulbert, B.A., University of Washington University. 1959. Grace E. Bergner, A.B., Washington Wisconsin, 1938; M.D., 1941. David W. Ortbals, B.S., St. Louis University, 1939; M.D., 1943. James H. Hutchinson, Jr., B.S., University, 1966; M.D., Washington John W. Berry, B.S., University of Arkansas A & M College, 1942; M.D., University, 1970. Toledo, 1943; M.D., St. Louis University of Arkansas, 1945. James W. Owen, Jr., M.D.. Washington University, 1946. Sidney Jick, M.D., Washington University. 1946. Clifford A. Birge, A.B., Amherst University, 1949. James C. Peden, Jr., A.B.. Havcrford College, 1956; M.D., Washington William G. Juergens, Jr., M.D., College, 1951; M.D., Washington University. 1961. Washington University. 1961. University, 1955. Benje Boonshaft, A.B., Washington Robert L. Kaufman, A.B.. Washington William J. Phillips, B.A.. Oklahoma University, 1957; M.D., 1961. University, 1959; M.D., 1963. State University. 1959; M.D., Benjamin A. Borowsky, M.D., John J. Kelly, B.S., Rockhurst College. Washington University, 1963. Washington University, 1958. 1959; M.D., St. Louis University, 1963. Kenneth C. Price, M.D.. University of William G. Bowen, B.S., Davidson Robert C. Kingsland, A.B., Washington Washington, 1951. College, 1970; M.D., University of University, 1933; M.D., 1937. Vincent J. Proskey, B.S., University of North Carolina, 1974. Detroit, 1954; M.D., Marquettc John H. Kissel, B.S., Georgetown University, 1964. Allan S. Brett, B.A., University of University, 1967; M.D., Harvard Pennsylvania, 1972; M.D., 1976. (See University, 1971. Gary A. Ratkin, B.A., Rice University, Medical Care Group.) 1963; M.D., Washington University, Norman P. Knowlton, Jr., B.S., 1967. (See Department of Radiology.) Robert M. Bruce, A.B., Washington Harvard University, 1942; M.D., 1945. University, 1964; B.S., University of Lester T. Reese (Dermatology), M.D., Ralph F. Kuhlman, M.D.. University of Minnesota, 1968; M.D., 1968. Tulane University, 1966. Illinois. 1964. (Also Student Health Harold K. Roberts, B.A., Ohio State Francis J. Catanzaro, M.D., Service.) Washington University, 1948. University, 1935; M.D.. 1939. Jerrold J. Lander, A.B., Washington Leon R. Robison, B.A.. Obcrlin Stephen R. Crespin, A.B., Harvard University, 1964; M.D.. 1968. College. 1960: M.D.. 1965. College, 1963; M.D., Case Western Morton A. Levy, B.A., University of Reserve University, 1968. John S. Daniels, A.B., Washington California at Los Angeles. 1957; M.D.. Joseph F. Ruwitch, Jr., M.D.. University, 1970; M.A.. University of Washington University, 1961. Washington University, 1966. Arkansas. 1974: M.D., 1974. Douglas R. Lilly, A.B., Princeton Ali Salimi, M.D., University of John D. Davidson, A.B.. Washington University, 1952: M.D., Washington Tehran, 1965. University. 1948; M.D., 1952. University. 1956. Vincent R. deMello, MB., B.S., Seth Warren M. Lonergan, A.B., G. S. Medical College. 1964. Westminster College, 1936; M.D.. Alexander E. Denes, A.B., Washington Vanderbilt University, 1940. University, 1969: M.D., University of William E. Magee, M.D.. Duke Missouri, 1973. University, 1950. Lewis C. Fischbein, B.A., University of Jay P. Marshall II, B.S., DePauw Rochester, 1970; M.D., Washington University, 1968; M.D., University of University, 1974. Missouri. 1972. Arthur H. Gale, B.S., Washington Thomas F. Martin, B.S., St. Louis University. 1955; M.D., University of University. 1961: M.D., 1965. Missouri. 1959. Robert S. Mendelsohn, B.A.. Melvin L. Goldman, A.B., Washington Washington and Lee University. 1950; University. 1939; M.D., 1943. M.D., Washington University. 1954. Benjamin M. Goldstein, A.B., Paul A. Mennes, B.S., University of Washington University, I960: Wisconsin. 1966; M.D.. Washington M.D.. 1964. University. 1970.

51 Samuel K. Schcchler, M.I). Washington Thomas R. Pohlman, A.B.. St. Louis Susan V. Hopper, A.B., Washington University, 1941. University, 1972; M.D., Washington University, 1968; M.A., 1970 and 1976; Alan R. Spivack, A.B., Washington University, 1976. Ph.D., 1978. University, I960; M.D.. St. Louis Susan B. Schneider, A.B.. Swarthmore Norma J. Janes, B.S., Millikin University, 1964. College, 1973; M.D., Yale University, University, 1953; M.S., State University Paul M. Stein, A.B., University of 1977. of Iowa, 1964. Rochester, 1967; M.D., St. I.ouis Daniel P. Schuster, B.A., University of Geoffrey S. Nash, B.Sc. McGill University, 1971. Michigan, 1972; M.D., Yale University, University, 1971. Robert IM. Taxman, A.B.. Washington 1976. Leonard Rifas, A.B., University of University, I960, M.D., 1964. Jeffrey G. Shanes, B.S.. Roosevelt Missouri, 1969; M.S.. 1973. Klliot A. Wallach (Dermatology), B.S., University, 1972; M.D., Chicago Hans P. Schwarz, M.D., University of College ol William and Mary, 1942; Medical School, 1976. Bern, 1971. Ml), Si Louis University. 1945. Janet L. Smith, B.A.. Bellarmine Shakuntla S. Seetharem, B.Sc, .lames W. Walsh, A B . Washington College. 1972; M.D., University of University of Lucknow, 1961; M.Sc, University, 1950; M.D.. 1954. Louisville. 1976. 1963; Ph.D., Madras University, 1974. Alan N. Weiss, B.A.. Ohio State William F. Southworth, B.A., Victor W. Shen, B.S., Tunghai University, 1963; M.D.. 1966. Washington University, 1969; University, Taiwan, 1968; M.S., Gerald A. Wolff, A.B.. Harvard M.D., 1975. University of Texas, 1974; Ph.D., 1976. University. 1955; M.D., Washington Elizabeth A. Stoddard, U.S.. Montana Elizabeth Warren-Boulton, R.N.. University, 1961. State University, 1954; M.D., Canberra Hospital School of Nursing, Washington University, 1957. (See John A. Wood, MI)., Oklahoma 1967; B.S., St. Louis University, 1975; Department of Preventive Medicine and University, 1968. M.S., 1977. Public Health.) Herbert B. Zimmerman, M.D., Joseph W. Yang, B.S., Tunghai Gregory A. Storch, A.B., Harvard Washington University, 1951. University. 1966; M.S., Illinois State University, 1969; M.D., New York University, 1971; Ph.D., 1976. University, 1973. Instructors Emeriti (Clinical) Ajit P. Varki, MB., Christian Medical Harry Agress, B.S., Washington Instructors College, 1974; B.S.. 1974. University, 1932; M.D., 1932. Klliot K. Abbey, A.B., Cornell Gary J. Weil, A.B., Harvard University, Louis F. Aitken, B.S., University of University, 1971; M.D.. New York 1971; M.D.. 1975. University, 1975. Illinois, 1923; M.D., Washington Mary F. Witt, B.A., Sweet Briar University, 1927. Greta Camel, A.B.. University of College, 1974; M.D., University of Edward W. Cannady, A.B., Washington Wisconsin, 1946; M.D.. 1949. Virginia. 1978. University, 1927; M.D., 1931. Ray K. (louse, U.S., Purdue University. Richard J. /.angara, U.S., Benjamin H. Charles, MB., Ch.B., 197.1; Ml).. Indiana University. 1976. Massachusetts Institute of Technology, University of Edinburgh. 1934. Thomas W. Cooper, A.B.. Johns 1973; M.D., University of Maryland. Hopkins University, 1972; M.D.. 1977. Norman W. Drey, A.B., Princeton Washington University. 1976. University, 1932; M.D.. Washington Research Instructor Emeritus University, 1936. Anne C. Goldberg, B A.. Radcliffe Teofil Kheim, M.D.. University of College. 197.1; M.D.. Universit) ol Alfred Fleishman, B.S., Washington Budapest, 1934. Maryland. 1977. University, 1935; M.D., 1935. Robert W. Karr, U.S.. Southwestern Research Instructors Axel R. Gronau, M.D.. University of University. 1971; M.D.. University of Hans D. Ambos Naples, 1935. lc\as. 1975. Claire H. Birge, B.A., Vanderbilt Lee B. Harrison, A.B.. University of Kwangsup S. Kim, M.D., Seoul University. I960; Ph.D.. Washington Utah, 1925; M.D.. Washington National University. 1963, University. 1971. University, 1927. Richard A. Uvy, B.S.. Tulane Randolph D. Cohen, B.S.. University of J. Ted Jean, A.B., Indiana University, Uimcisitv. 1967; M.D., Louisiana State Oklahoma, 1972: M.D., 1976. 1924; M.D., Washington University. 1971. William A. Crafford, Jr., B.A., University, 1928. Robert H. Marcus, A.B.. University of Vanderbilt University. I1'"!; M.D . Richard W. Maxwell, A.B.. Greenville California, Berkeley, 191); \1 1). Johns Hopkins University. 1976. College. 1932; M.D.. University of Chicago Medical School. 1974. (See Allen D. Galster. B.S.. University of Chicago, 1937. IVpartmenl ol Surgery t South Dakota. 1973; M.D.. Washington John W. Seddon, Ph.B., Yale University. Patricia M. Mauro, A B . Cornell University. 1977. 1931; M.D.. Washington University, 1973; M.D.. 1977. Ronald I.. Gingerich, B.A.. Goshen University, 1935. Steven R. Osa, B.A.. Universit) College. 1970; Ph.D.. Indiana Instructors (Clinical) of Kansas. 1973; M.D., Cornell University, 1975. (See Department of Ingrid R. Albert (Dermatology), A.B.. University, 1977. Pediatrics.) Barnard College, 1967; M.D., Albert H. MHchell Perry III. B.A.. Williams I). Jane Hamilton, B.S.. Baylor Einstein College of Medicine, 1971. College. 1971; Ml). Washington I niversity. 1956; M.S.. Washington Jorge M. Alegre, M.D.. San Marcos University, 1975. University, 1961. University, 1965.

S3 I

Jerome M. Aronberg (Dermatology), David E. Fisk, B.A.. Eastern Nazarene Ellis S. Lipsitz, A.B., Yale University, A.B., Washington University, 1967; College. 1966; M.D., Case Western 1940; M.D., St. Louis University, 1943. M.D., 1971. Reserve University, 1970. Carl A. Lyss, A.B.. Washington Frederick D. Bauschard (Dermatology), Branka F. Ford, B.A.. New York University, 1952; B.S., 1952; M.D., 1956. A.B., Allegheny College, 1964; M.D., University, 1965; M.D., McMaster David M. Margolis, B.Sc, University of University of Pittsburgh, 1968. University. 1978. (See Medical Care Manitoba, 1971; M.D., 1971. Group.) Daniel B. Bauwens, B.S., University of Jerald Maslanko, M.D., Emory Nebraska, 1971; M.D., Washington B. Todd Forsyth, M.D.. Washington University, 1975. (See Medical Care University, 1975. University. 1947. Group.) William W. Benedict, B.S., University of Philip S. B. Fuller, B.S., United States Henry E. Mattis, B.S., University of Illinois, 1971; M.D., Washington Military Academy, 1964; M.D., Illinois, 1971; M.D., Washington University, 1975. Jefferson Medical College, 1973. University, 1975. F. Douglas Biggs, B.A., Vanderbilt Kenneth W. Gentsch, A.B., Princeton Oliver A. McKee (Dermatology), University, 1968; M.D., Washington University. 1954; M.D.. Washington L.R.C.P.. Royal College of Physicians University, 1972. University, 1958. and Surgeons, 1949; S.M., 1949. Aaron Birenbaum, M.D., Washington Arnold M. Goldman, A.B., Harvard Charles W. Miller (Dermatology). B.S., University, 1948. University, 1955; M.D.. Washington Trinity College, 1968; M.D.. Dee C. Boswell, B.S., University of University, 1959. Washington University, 1972. Illinois, 1959; M.D., 1963. David A. Goran, B.A.. University of Austin F. Montgomery, M.D., Leslie M. Brandwin, B.S., City College Michigan, 1972; M.D., Washington University of Pittsburgh, 1954. of New York, 1967; M.D., St. Louis University, 1976. University, 1971. Arlen E. Morrison, A.B., Washington Ronald K. Grady, B.S., Purdue University, 1954; M.D., 1958. Robert A. Brinkman, B.S., Creighton University. 1956; M.S., 1957; M.D., Frede Mortensen, B.A., Wagner University, 1972; M.D., Washington Washington University, 1966. University, 1976. College, 1949; M.D., New York Medical Jitendra K. Gupta, MB., B.S., King College, 1953. Jeffrey S. Brooks (Podiatry), B.S., George Medical College, 1964. Lamar H. Ochs, A.B.. Washington University of Missouri, 1969; D.P.M., Anne Herron, M.B., B.Ch., Dublin University, 1941; M.D., 1944. New York College of Podiatric University, 1965. Medicine, 1974. S. Michael Orgel, A.B., Washington William E. Hinkley, B.A., Bowdoin University, I960; M.D., St. Louis John M. Cary, A.B., Central College, College, 1965; B.M.S., Dartmouth University. 1965. 1954; M.D., St. Louis University, 1958. University, 1967; M.D., Harvard Robert F. Owen, B.A.. Princeton Margaret Chieffi, M.D., University of University, 1969. University, 1948; M.D., Yale New Zealand, 1937. Bruce J. Hookerman (Dermatology), University, 1952. Frank Cohen, M.D., University of A.B., Dartmouth College. 1964; M.D., Daniel E. Potts, B.S., Baylor Toronto, 1939. St. Louis University, 1968. University, 1968; M.D., Washington Philip ('omens, B.S.Med., University of John L. Homer, A.B., Washington University, 1972. Missouri, 1949; M.D., Washington University, 1932; M.D., 1936. John A. Powell (Dermatology), B.S., Unversity. 1951. John W. Hubert, B.A., Wabash University of Notre Dame, 1967; M.D., Ralph Copp, Jr., A.B., Washington College, 1971: M.D., Washington University of Michigan, 1971. University. 1948; M.D., 1952. University, 1975. Ernest T. Rouse III, B.A.. Princeton Duane E. Co/art, Ph.B., University of Richard F. Huck, B.S., Notre Dame University, 1967; M.D., Washington Chicago, 1947; A.B.. Washington University, 1947; M.D., Washington University, 1971. University. 1949; M.D., Medical College University, 1948. Lawrence E. Samuels (Dermatology), of Virginia, 1959. Myron H. Jacobs, B.A.. Vanderbilt B.A., University of Texas. 1972; M.D.. Thomas A. Dew, B.S., Arkansas University, 1965; M.D., Louisiana State Washington University. 1976. A & M College. 1963; M.D., University University, 1969. Rafael Sanchez-Montserrat, B.S.. of Arkansas, 1967. Morris Joftus, M.D., University of Universidad de Puerto Rico, 1965; Royal J. Eaton, A.B., University of Illinois, 1967. M.D., Universidad de Barcelona. 1972. Missouri, 1959; M.D., 1964. Gary L. Jones, M.D., Baylor College of Jack L. Saylor, B.A.. Southern Illinois Russell E. Eggebrecht, B.S., University Medicine, 1977. University, I960; M.D., University of of Illinois. 1967; M.D., Washington Robert C. Kolodny, B.A.. Columbia Illinois, 1964. University, 1971. University, 1965: M.D., Washington Robert J. Schcff, A.B., Dartmouth David Feldman, M.D.. Washington University, 1969. College, 1970; M.D.. Washington University. 1943. Robert E. Kraetsch, B.S., University of University, 1974. Linda A. Fisher, B.A.. Douglass Illinois, 1965: M.D.. Washington Robert J. Schneider, A.B., Johns College, 1970; M.M.S., Rutgers University. 1969. Hopkins University, 1973; M.D.. 1976. University, 1972; M.D., Harvard Daniel K. Lane (Dermatology), B.A., John S. Schoentagf Dermatology), University, 1975. Princeton University, 1955; M.D., A.B., University of Missouri. 1956; Norman Fishman, B.A., Columbia Washington University, 1959. M.D., Washington University, 1960. College. 1970; M.D., Columbia College Steven A. 1 auter. B.S., Wayne State John B. Shapleigh II, Ml). of Physicians and Surgeons, 1974. University. 1968: M.D., 1971. Washington University, 1946. 1 53 I I

(•eriild S. Shut/, H.A.. Northwestern Research Associates Bakula L. Trivedi, M.S., Sarvajanik University, 1970; M.D., Washington Linda N. K. F. Abruzzini, B.S., Science College, 1961. University, 1974. University of Florida, 1975; Ph.D., 1980. Carol A. Weerts, R.N., St. John's John S. Skinner, M.I). Washington Marilyn J. B. Ackerman, US. Hospital School of Nursing. I960; B.S., L University, 1940. University of Wisconsin, 1969; Washington University, 1965; B.S., 1975; David Siinu'klrr, US, Georgetown M.S.T., 1970; Ph.D., Colorado State M.A., Webster College, 1980. University, 1974; M.D., 1978. University, 1978. Research Assistants Keith I). Stottlemyer, B.S., West liberty Dunell E. Conn, B.A., Swarthmore Sharon E. Carmody, B.A., Webster State College, 1966; M.I).. West Virginia College, 1965; M.A., University of College, I960. California, 1967; Ph.D., City University University, 1976. Howard L. Christopherson, B.S., of New York, 1975. Arnold S. Tepper, U.S., St. I.ouis University of Minnesota, 1949; College ol Pharmacy, 1966; M.D., John B. Costello, B.A., St. Louis M.S., 1953. University, 1974; M.D., 1977. University of Missouri, 1970. Frieda R. Chyn, A.B., University of William M. Thomson, U.S., Davidson Fanny M. Ebling, B.S., College of Missouri, 1971. Guayaquil, 1954; Ph.D., University of College, 1969; M.D., Johns Hopkins Leonard Cohen, B.A., State University Guayaquil, 1959. University, 1973. of New York, 1971; M.S., New York Sharon F. Tiefenhrunn, A.B., Jeffrey L. Evelhoch, B.S., West Chester University, 1975; M.D., 1977; Ph.D., Washington University, 1971; State College, 1977; M.S., University of 1977. California, Riverside, 1979; Ph.D., 1981. M.D., 1975. Margaret W. Erlanger, B.A., University Alice W. Trotter, B.A., Mount Holyoke Walter T. Gregory, B.S., St. Louis of Iowa, 1932; M.S.. 1938. University, I960. College, 1962; M.D., Washington Kiyoshi Fukui, M.D., Kyoto University, 1969. Keiji Kakita, M.D., Kawasaki Medical University, 1979. School, 1976. Dolores R. Tucker (Dermatology), U.S., Ann M. Grace, A.B., Bryn Mawr St. Mary's ol Notre Dame. 1958; Ml).. Annemarie Kronberger, B.S., University College, 1954; A.M., Washington Washington University, 1974. of Vienna, 1965; Ph.D., University of University, 1956; Ph.D., St. Louis John II. I lilniiiiiiii ( Dermatology). Sal/burg, 1978. University, 1970. B.A., Grinnell College. 1967; M.D.. Katherine D. Little, B.S.. Illinois Foster Harris, B.A., University of Washington University, 1971. Wesleyan University, 1952; M.S., Missouri, 1969. Albert I.. Van Amburg III. AH. University of Rochester. 1954; Thomas Howard, Sr. Washington University, 1968; M.D.. Ph.D., 1957. Milan D. Kapadia, B.S., Gujarat 1972. Patricia M. McKevitt, B.A., Clarke University, 1972; M.D., Indore College, 1967; M.S.W., Washington Richard C. Walters (Dermatology). University, l )74, U.S.. University ol Illinois. 1969; M.D., University, 1969. Catherine R. Keim, B.S.. Mercer Washington University, 197.1. Jagdish M. Mehta, B.S., Gujarat University, 1977. Hugh R. Waters, U.S., Northwestern University. 1960; M.S., 1962; University. 1942; M.D., Washington M.S., University of Missouri, 1966; Charles L. McConkey, Jr., B.A., Illinois University. 1945. Ph.D., 1968. Wesleyan University, 1969; M.S., Southern Illinois University, 1975. James R. W'iant, All. Princeton Lalji Mishra, B.S., University of University, 1955; M.D., Jefferson Allahabad, 1964: M.S., 1967; Ph.D., Dale F. Osborne, B.S.. Louisiana Medical College. 1959. University of California, 1973. State University, 1971. I Herbert C, Wicgand. A B., Washington Jozef Mruk, M.D.. Medical Academy Claire K. Pedersen, B.S., Quincy University. 1940; M.D.. 1943. of Krakow, 1975. College, 1948. R. Jerome Williams, Jr., A.B.. Harvard Sara L. Newell (Howard Hughes Betty F. Perry, A.B., Washington University, 197.1; M.D, Duke University. Medical Institute Research Associate). University. 1945. 1977. B.A.. Vassar College, 1969; M.S., M. Benjamin Perryman, B.S.. Emory Klsie W'instead, U.S., Fast Carolina University of Wisconsin, 1971; M.D., University, 1970; M.S., University of University, 1973; M.D.. University ol University of Iowa, 1975. Montana, 1972; Ph.D., Texas A & M North Carolina, 1977. (See Medical Audrey A. Painter, B.S., Southern University, 1980. Care Group.) Florida College. 1955; M.D., William T. Roswit (Dermatology), B.A., I Edward M. Wolfe (IVrmatology). B.A.. Northwestern University, 1957. Washington University, 1973. Ilobart College. 1956; M.D.. Helen Quill (Howard Hughes Medical Jesse T. Yates, B.S., Fisk Washington University, I960. Institute Research Associate), B.A., University, 1956. Trinity College, 1968; Ph.D., James A. Wood, AH.. Westminster Assistant (Clinical) 1 College. I'M'. M.D.. Washington Massachusetts Institute of Technology. 1979. John E. Mullins, A.B.. Washington University, 1949. University, 1954; M.D., 1958. Michael J. /.achek. U.S.. Georgetown Suresh D. Shah, B.S.. Gujarat University, 1973; M.D . 1977. University, 1956; M.S.. 1959: M.S.. St. 1 Jacob M. ZefTren. H A . Veshiva Louis University. 1972. University, 1971; M.D., St. Louis Esther M. Sternoerg, B.Sc. McGill University, 1975. University. 1972; M.D., 1974. 1

<4 Department of Microbiology and fi -£3^ Immunology

The department teaches a one-semester introductory course in microbiology for first-year medical students and for graduate students. The course is concerned particularly with principles of microbial physiology and genetics, and of immunology and, through a limited survey of pathogenic bacteria, viruses, and fungi, attempts to prepare medical students for more advanced study of infectious diseases later in the curriculum. The department also offers a number of advanced elective research activities. A limited number of summer research fellowships are available. FIRST YEAR Medical Microbiology Lectures and laboratory. This course presents the basic principles relating to the growth and reproduction of bacteria and viruses and to the immune responses of the host to diverse substances, including pathogenic microbes lmmunogenetics of complement proteins and the bio- and their metabolic products. The sequence followed is: chemistry and function of cell surface receptors for immunology and microbial physiology/ genetics followed immunoglobulins and complement. (Dr. Atkinson) by virology, and a survey of pathogenic bacteria and Mechanisms and evolution of gene transposition and of fungi. Medical students with sufficient background in one antibiotic resistance in bacteria. (Dr. Berg) of these subjects may substitute that section with a gradu- Biochemical polymorphism of lr gene products is studied ate course (see Electives). The immunology section with the aim of relating structure to immunoregulatory emphasizes structure, function and biosynthesis of anti- function. (Dr. Cullcn) bodies, and provides an introduction to cell-mediated immune responses and immunopathology. The microbial B cell subsets, mechanisms of antibody diversity. physiology and genetics section emphasizes aspects of (Dr. Davie) bacterial structure, growth, and reproduction which set Structure and biosynthesis of antibodies; immunoglo- the organisms apart from the human host. Later in the bulin gene expression in hybridoma cells. course, when specific groups of pathogenic organisms (Dr. Fleischman) and viruses are considered, the interaction between host Biochemistry of tumor viruses, varicella-zoster, and hepa- and parasite is studied by analyzing wherever possible the titis B virus. (Dr. Gelb) molecular basis for the pathogenicity of the microbe and Mechanisms of action of immune response genes. for the immune reactions of man. The factors that make (Dr. Kapp-Pierce) microorganisms vulnerable or resistant to chemothera- peutic agents are emphasized. Credit 6 units. (Staff) Biochemistry and genetics of macromolecule regulation: mRNA metabolism in bacteria; regulation of metabolism Individuals other than medical students may register in cultured mammalian cells. (Dr. Kennell) for individual sections of the course (see listing for the Division of Biology and Biomedical Sciences: under Bio Interactions of IgE and lgE receptors, structure of IgE 517, General Immunology, 2 units; Bio 523, Microbial and Fc receptors, mechanisms of immediate hypersensi- Physiology and Genetics, 1 unit; Bio 529, Animal Virol- tivity. (Dr. Kulczycki) ogy, 1 unit; Bio 533, Pathogenic Microbiology, 2 units). Differentiation and function of mononuclear phagocytes. (Dr. Lin) RESEARCH The structure and biosynthesis of lymphocyte cell surface Bio 590. antigens and lymphocyte triggering mechanisms. The These electives acquaint the student with the analyses effects as adjuvants in modulating the immune response. that are used in present-day biomedical research, espe- (Dr. Little) cially at the molecular level. (Staff) Development of therapy for intracellular bacterial and Processing and decay of RNA in E. coli and mammalian fungal infections. (Drs. Kobayashi, Medoff) cells, normal and malignant. Differentiation-activation of Tumor immunotherapy. Establishment of animal models unexpressed genes in mammalian cells. (Dr. Apirion) of human malignancy. (Dr. Medoff)

55 Cellular immunology; immediate hypcrsensitivity. Bio 528. Cell Development in Animals and in Culture (Dr. Parker) Lectures and student seminars on the fate of individual (iene expression in animal RNA viruses (vesicular stoma- cell types in animals and in cell culture. Principles of cell titis virus, poliovirus) with special emphasis on the regula- renewal exemplified in muscle, chondrocytes, and hemo- tion of viral RNA polymerase activities and the role of poiesis. Cell culture, including growth factors, hormonal detective interfering virus particles in the establishment factors, cyclic nucleotide effects, and genetics of cultured and maintenance of persistent viral infections. cells. Programmed cell death discussed along with the (Dr. Perrault) relation of differentiation to cell division, the role of cell-cell interactions, and studies of teratomas. Credit 3 Mechanisms regulating immune responses in tissue cul- units. (Drs. D. Schlessinger, Lieberman) ture systems. (Dr. Pierce) Biochemistry and replication ol oncogenic adenoviruses. Bio 534. Gene Expression and Differentiation in (Dr. Raskas) Eukaryotic Cells Interactions between RNA animal viruses and their host Emphasis will be on nuclear events which are relevant cells. Emphasis on maturation and assembly of viral to gene expression. Material covered will include exam- proteins. I he immune response to viruses: formation and ples mainly from Drosophila, mouse, chicken, and cells in properties of infectious viral-antibody complexes. tissue culture. We shall cover the cell cycle, mitosis, meio- (Dr. M. Schlesinger) sis, organization of chromatin and chromosomes, the content of the nucleus, chromosomal proteins, nuclear Structure and replication of enveloped RNA animal RNA, polytenic chromosomes, the transcription machin- viruses. (Dr. S. Schlesinger) ery, expression of rRNA genes in pro- and eukaryotes, Ribosome formation; processing and turnover of RNA in nucleolus, turnover and processing of RNA in the nucleus bacteria and mammalian cells. (Dr. D. Schlessinger) and cytoplasm, expression of the globin genes and genes Structure of histocompatibility and immune response induced by steroid hormones, teratomas, somatic cell region associated antigens. Molecular mechanisms under- genetics, nuclear cytoplasmic relationships, plasmids and lying HI.A-disease association. Mechanisms of Ht.A cloning of eukaryotic genes in bacteria. Credit 3 units. disease associations. (Dr. Schwartz) (Dr. Apirion) Bacterial plasmid gene function, especially resistances to Bio 539. Topics in Animal Virology heavy metals such as mercury, arsenic, cadmium and The course will consist of readings and seminars in silver. A combined approach to these resistances includ- specific areas of animal virology. The topics will vary ing genetic analysis with transposon mutagencsis and from year to year. Credit 2 units. gene cloning, physiological studies of the basis of resis- (Drs. M. Schlesinger, S. Schlesinger) tances, and biochemical analysis of the enzymes or other Bio 541. Molecular Biology of Prokaryotes cellular proteins responsible. (Dr. Silver) Growth, metabolism and genetics of the bacterial cell, Clinical microbiology, anaerobes, endogenous infections; including transport mechanisms, the regulation of gene enterics and enteric infections. (Dr. Sonnenwirth) expression and protein synthesis and the molecular biology of virus infection by virulent and temperate bacterio- EI.ECTIVES phages. The conceptual and experimental bases for pres- At present the primary enrollees in these courses are ent knowledge, as well as major problems to be solved, students working for a Ph.D. degree in one of the basic will be emphasized. About 15 hours of lecture followed by sciences. However, these courses are recommended for seminar presentations on selected topics by each student. interested medical students, especially those who may be Credit 2 units. (Dr. Kennell) considering a career in medical research. Emphasis is Bio 546. Antibodies: Structure, Function, and Formation placed on the organization and function of living systems The principal features of the structure and function of at the molecular level. The courses combine formal lec- antibody molecules will be examined in lectures, assigned tures with student-directed seminars. In the latter, each reading of current research papers, and in student seminar student has an opportunity to integrate various disci- presentations. Emphasis will be placed on the genetic and plines of modern molecular biology into the area of molecular events which govern the appearance of anti- biology or medicine that is of particular interest to him. bodies during the immune response. Those courses most relevant to the field of microbiology (Drs. Fleischman, Little, Prof. Simms) are listed under the Division of Biology and Biomedical Sciences. Bio 5051. Foundations in Immunology I This course is designed for graduate students as an Bio 521. Cellular Aspects of the in-depth introduction to immunology. Topics will Immune Response include: antibody structure and genetics, cellular immu- The mechanisms of regulation of immune responses by nology, complement, transplantation immunology, and antigen, macrophages. I cells. B cells and their products clinical immunology. Credit 3 units. (Dr. Kapp-Pierce) will be discussed. I he material covered will vary in emphasis from year to year and will stress critical analysis of the literature. Credit 2 units. Prerequisite: BIO 5051 Note—The number preceding the course title indicates and consent of instructor. (Also Pathology.) that the course carries credit in the Graduate School of (Dr. Pierce and Staff) Arts and Sciences.

Professor and Head of Department Milton J. Schlesinger, B.S., Yale Judith A. Kapp-Pierce, B.A.. Miami Joseph M. Davie, A.B.. Indiana University, 1951; M.S., University of University, 1965; M.S., Indiana University. 1962; M.A., 1964; Ph.D., Rochester, 1953; Ph.D.. University of University, 1969; Ph.D., Harvard 1966; M.D., Washington University, Michigan. 1959. University, 1976. (See Department of 1968. (See Department of Pathology.] Sondra Schlesinger, B.S., University of Pathology.) (Jewish Hospital.) Michigan. 1956: Ph.D., 1960. Benjamin D. Schwartz, B.A.. Columbia David Schlessinger, B.A., University of College, 1965; Ph.D., Albert Einstein Professors Chicago, 1955; B.S., 1957; Ph.D., College. 1971; M.D., 1972. (See David Apirion, M.S., Hebrew Harvard University, 1961. (See Department of Medicine.) University of Jerusalem. I960; Ph.D., Department of Medicine.) Ernest S. Simms University of Glasgow, 1963. Simon D. Silver, B.A., University of A ssistant Professors David E. Kennell, A.B., University of Michigan, 1957; Ph.D., Massachusetts Lawrence D. Gelb, B.S.. University of California, 1955; Ph.D., 1959. Institute of Technology, 1962. (Also Michigan. 1963; M.D., Harvard George S. Kobayashi, B.S., University of Faculty of Arts and Sciences.) University, 1967. (See Department California. 1952; Ph.D., Tulane Alexander C. Sonnenwirth, A.B.. of Medicine.) University, 1963. (See Department University of Nebraska, 1950; M.S., Henry V. Huang, A.B., Occidental of Medicine.) Purdue University, 1953; Ph.D., College, 1972; Ph.D., California J. Russell Little, Jr., A.B., Cornell Washington University. I960. (See Institute of Technology. 1977. University. 1952; M.D., University of Department of Pathology.) Anthony Kulczycki, Jr., A.B., Princeton Rochester, 1956. (See Department of (Jewish Hospital) University, 1966; M.D., Harvard Medicine.) (Jewish Hospital) University. 1970. (See Department Gerald Medoff, A.B.. Columbia of Medicine.) College, 1958; M.D., Washington Associate Professors Hsiu-san Lin, M.D., Taiwan University, University, 1962. (See Department John P. Atkinson, A.B., Kansas I960; Ph.D., University of Chicago, of Medicine.) University, 1965; M.D., 1969. (See 1968. (See Department of Radiology.) Charles W. Parker, M.D.. Washington Department of Medicine.) Richard B. Markham, A.B., Harvard University, 1953. (See Department Douglas E. Berg, B.S., Cornell University, 1969; M.D.. Albert Einstein of Medicine.) University, 1964; Ph.D., University of College of Medicine, 1972. (See Washington, 1969. (See Department Carl W. Pierce, A.B., Colgate Department of Medicine.) University. 1962; Ph.D., University of of Genetics.) Jacques Perrault, B.S., McGill Chicago. 1966; M.D., 1966. (See Susan E. Cullen, B.S., College of Mt. University, 1964; Ph.D.. University of Department of Pathology.) St. Vincent, 1965; Ph.D., Albert Einstein California, 1972. (Jewish Hospital) College. 1971. (See Department Heschel J. Raskas, B.S., Massachusetts of Genetics.) Research Assistants Institute of Technology, 1962; Ph.D.. Julian B. Fleischman, B.S., Yale John Courtney, A.B., University of Harvard University. 1967. (See University, 1955; Ph.D., Harvard Illinois, 1953. Department of Pathology.) Univeisity, 1960. Richard J. McDonald

57 I [

Several informal organizational groups of faculty Department of members are established for specialized research and teaching purposes. They include: Neurology and James L. O'Leary Laboratory of Experimental Neurol- ogy and Neurological Surgery, Dr. Jones (Director). Neurological Division of Pediatric Neurology, Dr. Prensky(Director), Drs. Carroll, Deuel, Dodge, Dodson, Johnson, Rothman, Volpe. Surgery Division of Clinical Neuropharmacology, Dr. Ferrendelli (Director), Drs. Clifford, Dodson, Lolhman, Wooten. Neurology and neurological surgery concern them- Division of Neuromuscular Diseases, Dr. Brooke (Direc- selves with the diseases of brain, spinal cord, peripheral tor), Drs. Carroll, Eliasson, Nemeth. nerves, and muscles. An introduction to the anatomy and physiology of the nervous system is presented in the Groups concerned with particular neurological illness first-year course in neural sciences provided by the research areas include: 1 )cpai tments ot Anatomy and Neurobiology and of Phy- Cerebral Circulation and Metabolism, Drs. Collins, siology anil Biophysics. In the second year, the depart- Grubb, Herscovitch, Powers, Raichle. ment presents the course in I'athophysiology of Nervous Convulsive Disorders, Drs. Clifford, Dodson, System Disorders. Mere are demonstrated the interrela- Ferrendelli, Goldring, Lothman, Prensky, Vastola. tionships between knowledge derived from basic investi- Demyelinating Diseases, Drs. Agrawal, Trotter. gative and clinical sources. In addition, there are lectures Disorders of Movement, Miss Clare, Drs. Landau, and exercises with patients in neurological physical diag- Montgomery, Sahrmann, Thach, Wooten. nosis. A lull-time four-week clerkship in the third year, with collaborative teaching by both Neurology and Neu- Memory Aging, and Dementia, Drs. Berg, Cohen, rological Surgery services, introduces the phenomenol- Danziger, Hughes, Raichle. ogy of the diseased nervous system. In the fourth year, Metabolic Diseases of Children, Drs. Dodson, Prensky. there are opportunities for clinical externships and many varieties of research experience. SECOND YEAR Pathophysiology of Nervous System Disorders (part of course in pathophysiology) A collaborative sequence concerned with mechanisms of disease of the nervous system. Lectures and seminar- symposia. (Dr. Eliasson, Thach, and combined Neurology-Neurosurgery Staff) Neurological Examination in Clinical Diagnosis (part of interdepartmental course in clinical diagnosis) Lectures, demonstrations, and practice examinations of neurological patients. (Dr. Eliasson and Staff)

THIRD YEAR Combined Neurology-Neurosurgical Clerkship A full-time, four-week clerkship is provided on the neurology services at Barnes and City Hospital-Starkloff Memorial and the Barnes Hospital neurosurgical service. Patients are assigned to students who follow them with the resident staff and discuss them regularly in conferences with the senior neurological and neurosurgical staff. Students also work in the neurology and neurosurgical clinics under staff supervision. (Drs. Eliasson, Landau, Goldring, and Staff)

FOURTH YEAR ELECTIVES Research A 6- to 12-week elective is available in many areas such as neuroanatomy, neurophysiology, cerebral metabolism and circulation, neurochemistry, neuropharmacology. n etc. Facilities are available for qualified students in any attending staff. Students also work in the Neurosurgical year to undertake original research in the laboratories of Clinic and attend the weekly staff conferences. the department or in the clinics and wards. (Dr. Goldring and Staff) (Drs. Goldring, Landau, and combined Neurology- Staff Conferences Neurosurgery Staff) Students are invited to attend the Conjoint Neurologi- Clinical Neurology cal Conference (neuropathology. neuroradiology, medi- A six-week subintern elective on the Starkloff Hospital cal neurology, pediatric neurology, and neurological neurology service provides direct patient responsibility as surgery) held on Wednesday afternoon. The conference is a member of the housestaff team. Organized conferences held in West Pavilion Auditorium at 1:30 p.m. except on and readings with housestaff members and staff are pro- the second Wednesday of each month, when it is held at vided. (Dr. Collins and Staff) City Hospital-Starkloff Memorial at 1:45 p.m. in the A six-week consult elective is offered at Barnes Hospi- third-floor conference room. The format of the conferences includes clinical presentations, symposia, and tal. The student works directly with the consult resident and senior staff covering consultations at Barnes and CPCs. Neurosurgery Grand Rounds arc held weekly at 4:00 p.m. on Friday in the Neurosurgery conference Jewish Hospitals. Selected reading assignments on cur- room, 511 McMillan Hospital. Neuropathology brain- rent topics in neurology (Dr. Eliasson and Staff) cutting conferences are held weekly in the Pathology A six-week consult elective organized in the same Department on Monday at 1:00 p.m. and in the Starkloff manner is offered at Starkloff Hospital. Hospital morgue biweekly on Monday at 11:15 a.m. In (Dr. Collins and Staff) alternate weeks a seminar in pathophysiology is held on Clinical Neurosurgery Division 20. Dr. Brooke conducts a rehabilitation con- The goal of the six-week clerkship at Barnes Hospital is ference in the rehabilitation satellite unit on 11400 Barnes to provide an overview of neurological surgery. Respon- at noon on Monday. Professor's rounds, dealing system- sibilities include patient workup, pre- and post-operative atically with major problem areas of clinical neurology, care, and attendance at selected neurosurgical operations. are held at noon on Tuesday in the Barnes 11400 class- Daily teaching rounds are held with a member of the room.

Faculty of the Department of Neurology

Co-Heads of Department A. Ernest and Jane G. Stein Professor Edward G. Jones (Neuroscience), Sidney Goldring, William Landau of Developmental Neurology M.B.,Ch.B., University of Otago, 1962; Joseph J. Volpe, B.A., Bowdoin Ph.D., Oxford University, 1968; M.D., College, I960: M.D., Harvard University of Otago, 1970; George H. University, 1964. (See Departments of and Ethel R. Bishop Scholar in NEUROLOGY Biological Chemistry and Pediatrics.) Neuroscience in Neurology and Andrew B. and Gretchen P. Jones Neurological Surgery. (See Neurological Professor of Neurology and Head Surgery and Department of Anatomy William M. Landau, M.D., Washington Professors and Neurobiology.) University, 1947. Harish C. Agrawal (Neurochemistry), Alan L. Pearlman, A.B.. State B.Sc, Allahabad University, 1957; University of Iowa. 1958; M.D.. Professor and Vice Chairman of M.Sc, 1959; Ph.D., 1964. (See Washington University. 1961. (See Neurology Departments of Pathology and Department of Physiology Sven G. Eliasson, Ph.D., University of Pediatrics.) and Biophysics.) Lund, 1952; M.D., 1954. (See Irene Michael H. Brooke, MB., B.Ch., Marcus E. Raichle, B.S.. University of Walter Johnson Institute of Cambridge University. 1958. (See Washington, 1960; M.D.. 1964. (See Rehabilitation.) Department of Preventive Medicine and Department of Radiology.) (Also Public Health and Irene Walter School of Engineering and Seay Professor of Clinical Johnson Institute of Rehabilitation.) Applied Science.) Neuropharmacology Ronald M. Burde. B.S., Massachusetts W. Thomas Thach, Jr., A.B., Princeton James A. Ferrendelli, A.B., University Institute of Technology, I960; M.D., University, 1959; M.D.. Harvard of Colorado. 1958; M.D.. 1962. (See Jefferson Medical College, 1964. (See University, 1964. (See Department of Departments of Pharmacology and Departments of Ophthalmology and Anatomy and Neurobiology.) Ophthalmology.) Neurological Surgery.) Edward E. Vastola, B.S., Yale Margaret H. Clare (Neurophysiology). University. 1945; M.D., Columbia Allen P. and Josephine B. Green B.S.Ed.. Southeast Missouri State College of Physicians and Surgeons. Professor of Pediatric Neurology Teachers College, 1940; M.A.. 1947. (Starkloff Hospital) Arthur L. Prensky, A.B.. Cornell Washington University. 1951. University. 1951; M.D., New York Philip R. Dodge, M.D., University of Professors (Clinical) University, 1955. (See Department Rochester. 1948. (See Department Leonard Berg, AH. Washington of Pediatrics.) of Pediatrics.) University. 1945; M.D.. 1949.

59 E [ Herbert K. Kosenbaum, B.S., University I i»m B. Montgomery, Jr., B.S., State Assistant Professors (Clinical) of Oregon, 1947; M.D., 1949. University of New York, Buffalo, 1972; Joseph T. Black, B.A., University of Stuart Weiss, All., Washington M.D., 1976. Rochester, 1961; M.D., State University University, 1950; M.D., 1954. Patti M. Nemeth (Myochemistry), B.S., of New York, Upstate, 1965. University of Arizona, 1969; Ph.D., Octavio de Marchena, A.B., Johns Associate Professors University of California, 1977. Hopkins University, 1972; M.D., 1976. Lawrence A. Cohen, B.S., Western (See Department of Anatomy and Joseph M. Dooley, Jr., B.S., St. Louis Reserve University, 1948; M.D., Neurobiology.) University, 1954; M.D., 1958. Western Reserve University, 1954. M.A., William J. Powers, A.B., Dartmouth Joseph Hanaway, B.A., McGill Northwestern University,' 1951 (Also College, 1971; M.D., Cornell University, 1956; M.D., 1960; Computer Systems Laboratory.) University, 1975. CM., I960. Hubert C. Collins, B.A., University of Steven M. Kothman, M.D.. State William B. Hardin, B.S., Rice California, Berkeley, 1964; M.D., University of New York, Upstate, 1969. University, 1953; M.D., University of Cornell University, 1969. (See Departments of Anatomy and Texas Medical School at (Starklofl Hospital) Neurobiology and Pediatrics.) Galveston, 1957. Kuthmary K. Deuel, B.A.. Mount Shirley A. Sahrmann (Neuro- David M. Reisler, A.B., Harvard Holyoke College, 1956; M.D., physiology), B.S.P.T., Washington University. 1957; M.D.. Washington Columbia College of Physicians and University, 1958; M.A.. 1971; Ph.D.. University. 1961; M.P.H., Johns Surgeons, 1961. (See Department of 1973. (Sec Department of Physiology Hopkins University, 1971. Pediatrics.) and Biophysics and Program in Eli R. Shuter, A.B., Cornell University, W. Hdwin Dodson, A.B., Duke Physical Therapy.) 1956; M.D., Washington University, University, 196.1; M.D., 1967. (Sec Clifford B. Saper, Ph.D., Washington I960. Department ol Pediatrics.) University, 1977; M.D., 1977. Instructors Charles I'. Hughes, B.A., Yale Research Assistant Professors University, I960; Ml), Case Western David B. Clifford, B.A., Southwestern ( liiimi I limn Cheng, B.S., China Reserve University, 1964. University, 1971; M.D., Washington National Central University, 1944; M.S.. (Starkloff Hospital) University, 1975. Cornell University, 1950; Ph.D., John L. Trotter, AH, DePauw Michigan State University, 1955. John Michael Hatlelid, B.A., St. Johns University, 1965; M.D., Washington University, 1970; M.D., Washington Joseph Inukai (Sec Neurological University, 1969. (Cordon R. and University, 1977. Surgery.) I helma B. Coates Scholar Peter Herscovitch, B. Eng., McGill in Neurology.) Kenneth K. Kaiser, B.S., Colorado University, 1971; M.D., CM., 1975. State University, 1968. George K. Wooten, Jr., B.A., Rice William Robert Wayne Martin, B. Med. University, 1965; M.D., Cornell Lloyd N. Simpson (See Sci., University of Alberta, 1973; University Medical College. 1970. (See Neurological Surgery.) M.D., 1975. Department ol Pharmacology.) Arthur W. Toga, B.S., University of Instructor (Slarklofl Hospital) Massachusetts, 1974; M.S., St. Louis University, 1975; Ph.D., 1978. Michael Noetzel, A.B., Yale, 1973; M.D., University of Virginia, 1977. Associate Professors (C linical) Karl R. Schultz, AH. Southeast Instructor (Clinical) Missouri Stale College. 1952; B.S.Mcd.. Robert J. Mueller, M.D., Washington University ol Missouri, 1953; M.D., University, 1936; M.S., University of Washington University. 1955. (Sec Michigan, 1942. Department ot Psychiatry.) Research Assistants Richard S. Sohn, U.S., Brooklyn David Yuen-Kai Chi, B.A., Greenville College. 1964; M.D.. University of College. 1970; M.S.. St. Louis Chicago. 1968. University, 1976. Warren L. Danziger, A.B., Washington Assistant Professors University, 1973; Ph.D., 1979. James E. Carroll. US. University ol Julaine Florence, B.S., Washington 1 OUISMIIC. 1966; M.D.. 1969. (See University, 1975. Department of Pediatrics and Irene Walter Johnson Institute of Ann C. McKeon, B.S., Boston Rehabilitation.) College, 1975. Mary 1. Johnson. B.S.. Washington JoAnne D. Scarpellini, B.S.. Indiana State University, 1964; M.D., Johns State University, 1955. Hopkins University. 1968. (See Jeanne M. Smith Departments ol Anatomy and Neurobiology and Pediatrics.) NEUROLOGICAL SURGERY Brit William 1 othman, B.A.. Duke Professor and Head University. 1969; Ph.D.. 1974; M.D., Sidney Goldring, B.S.. Washington 1975. (Starkloff Hospital.) University, 1943; M.D., 1947.

M August A. Busch, Jr., Professor Henry G. Schwartz, A.B., Princeton University, 1928; M.D., Johns Hopkins University, 1932.

Professors Ronald M. Burde, B.S., Massachusetts Institute of Technology. 1960; M.D., Jefferson Medical College, 1964. (See Departments of Ophthalmology and Neurology.) William S. Coxe, B.S., Hampden- Sydney College, 1945; M.D., Johns Hopkins University, 1948. Mokhtar Gado, MB., B.Ch., Cairo University, 1953; DMRE, I960. (See Department of Radiology.) Robert L. Grubb, Jr., A.B., University of North Carolina, 1961; M.D., 1965. (See Department of Radiology.) Edward G. Jones (Neuroscience), M.D., Ch.B., University of Otago, 1962; Ph.D., Oxford University, 1968; M.D., University of Otago. 1970; George H. and Ethel R. Bishop Scholar in Neuroscience in Neurology and Neurological Surgery. (See Neurology and Department of Anatomy and Neurobiology.) Research Assistant Professors J. Stevadson IWassey, B.A., University Robert A. Ratcheson, B.S., Joseph Inukai (See Neurology.) of the South, 1977; B.S.. Washington Northwestern University, 1962; University, 1980. M.D.. 1965. Lloyd N. Simpson (See Neurology.) Cheryl Ann Myrick, B.S.N., St. Louis Research Assistants Assistant Professor University, 1979. Isaac A. Edwards Arthur B. Jenny II, A.B., Johns Jeanne Me. Smith (See Neurology.) Hopkins University, 1965; M.D., 1969; Stuart A. Golden, B.S.. Washington Ph.D., Washington University, 1980. University, 1974.

61 in the techniques of steroid and gonadotropin quantita- Department of tion as well as various manipulative procedures. (Dr. Warren) Obstetrics and Pathology Externship The elective elucidates the principles of anatomic pathology as applied to operative material in obstetrics Gynecology and gynecology. The extern examines gross and microscopic specimens in the Ob-Gyn Pathology Laboratory The Student's involvement in obstetrics and gynecol- and reviews pertinent literature with a senior pathologist. ogy consists of a thorough exposure to the basic concepts (Dr. Gersell) in reproductive biology and an active participation in the Gyn Oncology Externship delivery ol medical care to women with gestations normal This elective concerns itself with the diagnosis and or at risk, congenital anomalies of pelvic viscera, struc- treatment of malignant tumors of the female reproductive tural disorders secondary to difficult childbirth, repro- tract. The extern is involved in all aspects of the care of ductive endocrinopathies and infertility, and gynecologic women with gyn malignant tumors. This experience will malignancies, The junior clerkship is conducted at Barnes include the surgical treatment, radiation therapy and Hospital, Jewish Hospital and St. Louis County Hospi- chemotherapy. (Dr. Camel) tal, with the majority of the students stationed at Barnes. Perinatal Medicine Externship Senior electives may be taken at Barnes Hospital or in the Electronic and biochemical surveillance of the human many affiliated hospitals in St. I.ouis. Regularly held fetus and mother before and during parturition. The conferences in reproductive biology, perinatal medicine, extern is involved in the care of women with gestations at ob-gyn pathology, and oncology supplement the stu- risk (i.e.. diabetes, hypertension, toxemia, renal disease, dent's education. fetopelvic disproportion, etc.). (Dr. Arias) SECOND YEAR Ob-Gyn Preceptorship I he sophomore is introduced to obstetrics and gyne- The student spends six weeks with a clinical faculty cology with lectures in reproductive biology which apply member who is in private practice. He makes hospital the pelvic anatomy and physiology taught in the first year, rounds and operates with his preceptor at Barnes and physiology of tubal transport and ovarian control, myo- other community hospitals. He becomes familiar with the metrial function, placental perlusion, steroidogenesis, experiences of the private practitioner. (Dr. Warren) genetics, and prenatal diagnosis. THIRD YEAR Students are assigned to a resident-staff team, and the residents and staff physicians serve as preceptors during the students' six-week stay in the department. Every woman seen in the office or cared for in the hospital by the team of physicians is considered in her entirety. Attention is paid to the manner in which her social and economic situation has modified her response to disease. Environ- mental manipulation, in addition to traditional medical care, is prescribed to improve her health. I he team method ensures that personalized care is given by arranging for the same group of physicians to meet a woman's health needs during each visit. I he residents in a team function like a group in obstetrics and gynecology practice, and the student works like an intern in the specialty. He sees patients in the office with his resident group, attends deliveries, assists in surgery, goes to conferences and lakes night call with them as a part of the team. FOURTH YEAR Seniors wishing to take .111 externship 01 research elective can choose from a variety of courses: Ob-Gyn Externships Endocrinology-Infertility Externship In the office and hospital, the extern participates in the study and treatment of women with reproductive endocrine disorders and infertility. He presents patients in conferences, has assigned reading, and obtains experience

f.: Endocrinologic Function and Disease During Pregnancy General Ob-Gyn Externships Subinternship St. Louis County Hospital (Dr. Siemens) While on elective, the senior student will participate in The externship in each of these affiliated hospitals allows clinical and/or research activities leading to a basic the student a greater degree of participation and respon- understanding of the endocrinology of pregnancy and sibility in the care of patients. There is a wealth of clinical endocrine dysfunction during pregnancy. He will present material in each of these facilities. patients in conferences, have assigned reading and obtain experience in clinical research techniques. (Dr. Rigg) RESEARCH ELECTIVES Genetics Subinternship This elective involves clinical exposure to preconcep- Molecular Aspects of Endocrinology and Population tional and preamniocentesis counseling, methods of pre- Control natal diagnosis (genetic amniocentesis, diagnostic ultra- The research involves the study of the topography of sound, amniography, etc.) and physical diagnosis of macromolecular steroid binding sites, evaluation of the genetic disease. Laboratory experience in cytogenetic role of steroid "receptor" proteins in molecular mecha- techniques such as amniotic fluid, lymphocyte, bone mar- nisms of steroid action, and the synthesis of affinity- row and tissue culture is also included. (Dr. Crane) labeling steroids and anti-steroids and their application to disease states and population control. (Dr. Warren) Obstetric Anesthesiology Radioimmunoassay In this clinical elective, students receive instruction in Radioimmunoassay is now the most widely applied in the fundamentals of obstetric pain relief and newborn vitro assay procedure. This elective is designed to acquaint infant management and resuscitation. The pharmacology the student with basic theoretical considerations as well as of sedatives, tranquilizers, narcotics, local anesthetics, with technical and practical applications of assays of inhalation and intravenous drugs is demonstrated by value in obstetrics and gynecology. The student will be practical application, emphasizing fetal-maternal impli- given opportunity to develop, evaluate and apply clini- cations in the management of labor. Special local anes- cally an assay of choice. (Dr. Wiest) thetic blocks such as caudal, lumbar epidural, and saddle Regulation of Placental Hormone Synthesis spinal. Experience is also gained in the management of Our laboratory is concerned with studying the factors general anesthesia for minor gynecologic precedures such regulating the biosynthesis of protein hormones in the as postpartum tubal ligations. placenta, human placental lactogen (hPL), and human (Dr. Jones) chorionic gonadotropin (hCG). The appearance of these hormones in maternal serum differs markedly. For these studies the template mRNAs have been isolated and we are generating complementary DNAs to the correspond- ing mRNAs. These DNA probes will be used to assay mp gene activities in normal and pathological tissues. Stu- dents will be concerned with the concepts and techniques of molecular biology as applied to the above research. (Dr. Boime) Sperm Biochemistry and Andrology Research is performed which is aimed at the understanding and control of the molecular events which allow for sperm penetration of the ovum. Investigations into male infertility centering on sperm motility, bacteriolog- ical considerations, and freezing of semen are also conducted. (Dr. Polakoski) Bio-Organic Chemical Endocrinology The mechanism of steroid hormone action at the molecular level is approached by producing new progesterone and estrogen analogs by organic synthesis. The student can work at the organic synthetic or biochemical level. Isolation of uterine estrogen and progesterone receptor proteins by a newly synthesized affinity chromatography system is in progress. Also, new steroids, con- taining alkylating functional groups are synthesized and have a dual research role: to serve as tools with which to probe the steroid-macromolecular binding phenomenon and to produce biologically active steroids with persistent hormone activity or hormone blocking action. Physio- chemical methods are used to study steroid-protein inter- 1 action. (Dr. Sweet)

63 Faculty of the Department of Obstetrics and Gynecology

Professor and Head of Department Ernst R. Friedrich, MB., University of Sau Wai Cheung, B.S., New Asia James ('. Warren, AH, University of Berlin, 1951; M.D., University of College. 1966; M.S., University of Wichita, 1950; MI)., University of Heidelberg. 1954. Louisville. 1969; Ph.D., Indiana Kansas, 1954; Ph.D., University ol James D. Jones II, U.S., Louisiana University, 1975. Nebraska, 1961. (See Department of State University. 1940; D.D.S., Loyola Biological Chemistry.) University of the South, 1945; M.D., Assistant Professors Emeriti (Clinical) University of Alabama, 1957. (See William Berman, A.B., Washington Professor Emeritus Department of Anesthesiology.) University, 1931; M.D.. 1935. Willard M. Allen, B.S., Hobart College. Ming-Shian Kao, M.D.. National Arthur R. Bortnick, M.D.. Washington 1926; M.S.. University of Rochester, Taiwan University Medical University, 1935. 1929; M.I).. 1932; Sc.D. (hon.), Hobart College. 1961. College, 1940; Sc.D. (hon.). University Arthur T. Esslinger, M.D.. Washington ol Rochester, 1957. David W. Keller, B.S., Canisius College. University, 1940. 1960; M.D., University of Buffalo. 1964. Kevin C. Morrin, M.B., B.Ch., National Professors Kenneth V. Polakoski, B.S.. Wisconsin University of Ireland. 1921. Fernando Arias, Ml).. National State University. 1966; M.S., University Willard C. Scrivner, B.S., Washington University of Bogota, 1958; Ph.D.. of Georgia. 1971; Ph.D., 1972. University, 1926; M.D., 1930. lulanc University, 1965. Jacques Sauvage, B.S., University ol Helman C. Wasserman, A.B.. Johns Irving Koime, U.S.. St. Louis College ol Liege. 1953; M.D., 1957. Hopkins University, 1928; M.D.. Pharmacy, 1964; M.S., Purdue Ronald C. Strickler, B.S.. University of Washington University, 1932. University, 1966; Ph.D.. Washington Toronto, 1963; M.D., 1967. University, 1970. (See Department ol Frederick Sweet, B.S.. City University Assistant Professors (Clinical) Pharmacology.) of New York, 1960; Ph.D., University of Robert S. Cohen, B.S., Union College, II. Marvin Camel, M.D.. Creighton Alberta. 1968. 1958; M.D.. State University of New University, 1950. Associate Professor Emeritus (Clinical) York, 1962. Walter G. Wiest, A.B., Brigham Young David B. Rothman, B.S., Washington Andrew Galakatos, US. St. Louis University. 1948; Ph.D.. University of University, 1935; M.D., 1935. College of Pharmacy, 1960; M.D., Wisconsin, 1952. (See Department of University of Missouri, 1965. Biological Chemistry.) Associate Professors (Clinical) Robert S. Goell, A.B.. Middlebury S. Michael Kreiman, A.B.. Montana College. 1949; A.M., University of Professors Emeriti (( linical) Stale University. 1951; M.D., A. Norman Arneson, US. Ie\as Pennsylvania, 1950; M.D., Washington Washington University. 1955. University, 1960. Christian University. 1924; Ml).. Frank B. Long, Jr., M.D.. Washington C. Richard Gulick, B.A., Westminster Washington University, 1928. (See University. 1947. Department of Radiology.) College. 1966; M.D.. University of J. Barlow Martin, B.A.. Amherst Rochester. 1971. John K. Ilohbs, A.B.. Southwest College. 1951; M.D., Washington Jacob Klein, B.S., Muhlenberg College. Missouri State Ieachers College. 1923; University, 1955. M.D.. Washington University. 1927. 1964; M.D.. Jefferson Medical Norman K. Muschany, A.B.. College, 1968. Melvin A. Koblee, U.S.. Washington Westminster College. 1947; M.D., Laurence E. Maze, M.D.. Washington University, 1923; M D. 1925. Temple University. 1951. Samuel D. Soule, Ml). Washington University, 1948. Assistant Professors University. 1928. Seymour M. Monat, A.B., University of Michael J. Cast, B.S.. University of Pennsylvania. 1935; M.D., Long Island Professors (( linical) Illinois. 1970; M.D.. Ohio State College. 1939. Robert Burstein. Ml). Washington University. 1973; Ph.D.. Washington James Pennoyer, B.S., Hobart College. University. 1981. University. 1948, 1933; M.D., University of Charles R. Gulick. A.B.. Central Alfred B. Knight, B.S., Massachusetts Rochester, 1939. College. 1940; M I)., St. Louis lnsitute of Technology. 1968; M.D., Edward G. Peskin, B.A., University of Case Western Reserve University. 1972. University, 1943. Wisconsin. 1970; M.D.. Washington William H. Masters, B.S.. Hamilton Tom E. Morgan, A.B.. Vanderbilt University. 1974. (See Medical College. 1938; M.D.. I'imcrsilv ol University. 1969; M.D.. University of Care Group.) Tennessee, 1972. Rochester, 1943. Jonathan R. Reed, B.A., Fisk I.ee A. Rigg, B.A.. Arizona State Associate Professor Emeritus University. 1956; M.D.. Meharry University. 1961; Ph.D.. University of Medical College, 1965. <;*or(>f J. I.. WulfT.Jr.. A.B.. Colorado. 1965; M.D.. Washington Marvin Rennard, A.B.. Washington Washington Univcrsitv. 1929; University. 1971. M.D.. 1933. University, 1947; B.S.. University of Research A ssistant Professors Missouri. 1950; M.S., 1950; M.D., Associate Professors Chang-chen Chin, B.S.. National Washington University. 1952. James P. Crane, A.B., Indiana University, 1944; Ph.D.. Oklahoma Melvin M. Schwartz, A.B.. University of Univcrsitv. 1966; M.D.. 1970. State University. 1967. Nebraska. 1945; M.D.. 1947.

(.4 William L. Smiley, A.B., Ohio State Robert L. Becker, B.A., Cornell Justin F. Kraner, M.D., University of University, 1933; M.D., 1937. University, 1965; M.D., Washington Michigan, 1949. Chotchai Srisuro, M.D.. Faculty of University, 1969. Theodore Merrims, A.B., Washington Medical Sciences. 1967. Joe E. Belew, A.B., Central College, University, 1949; M.D., 1954. Eugene D. Taylor, B.S., Virginia State 1953; M.D., St. Louis University, 1957. Jerry N. Middleton, B.A., Westminster College. 1948; M.D., Howard Robert H. Duemler, A.B., Washington College, 1959; M.D.. Washington University. 1954. University, 1952; M.D., 1956. University, 1963. M. Bryant Thompson, A.B., Eastern Ira C. Gall, B.S., University of F. Delbert Moeller, B.S.. Muskingum New Mexico University, 1957; M.D., Cincinnati, 1948; M.D., 1951. College, 1965; M.D., Ohio State University of California, 1961. John A. Hamilton, B.S., University of University, 1969. J. Leslie Walker, B.A., Vanderbilt Michigan, 1972; M.D., St. Louis Sam Momtazee, M.D., Shiraz Medical University, 1957; M.D., University of University, 1976. School, 1961. Tennessee, I960. Joseph Hazan, M.D., Ege University Nathaniel H. Murdock, B.S., Harvard Ronald P. Wilbois, B.S., University of Medical School, 1971. University, 1958; M.D., Meharry Illinois, 1959; M.D., 1964. Randall L. Heller, Jr., B.S., University Medical College, 1963. Carol F. Williams, B.A., University of of Missouri, 1964; Ph.D., 1968; M.D., Gerald Newport, A.B., Washington Tennessee, 1952; M.D., 1955. University of Texas. 1976. University, 1948; M.D., 1953. Godofredo ML Herzog, B.S., Louisiana Joseph D. O'Keefe, A.B., University of Instructor State University, 1953; M.D., Colorado, 1946; M.D.. Washington Washington University, 1957. University, 1950. Carolyn M. Siemers, B.A., Lindenwood College, 1970; M.D., Washington William L. Holcomb, B.S., Purdue William E. Pearson, B.S., Texas University, 1976. University, 1970; M.D., Indiana Christian University, 1964; M.D., University, 1975. Washington University, 1968. Instructors Emeriti (Clinical) Darwin C. Jackson, B.S., Ohio State Chinda Vanasin Rojanasathit, M.D., Hubert L. Allen, A.B., University of University, 1972; M.D., Washington Siriraj Medical School, 1967. Kansas, 1932; M.D., Tulane University, 1976. James Sawyer, A.B.. Ohio State University, 1936. Michael K. Johnson, B.S., Ohio State University, 1949; M.D., 1951. Frances H. Stewart, M.D., Washington University, 1970; M.D., St. Louis Albro C. Tobey, Jr., B.S., Butler University, 1927. University, 1975. University, 1965; M.D., Trinity College, James W. Kessel, M.D., University of University of Dublin. 1972. Instructors (Clinical) Chicago, 1975; Ph.D., California Parker H. Word, B.S.. Virginia State Scott Barrett, Sr., M.D., Meharry Ipstitute of Technology, 1963. College, 1941; M.D., Howard Medical Medical College, 1938. S. Robert Kovac, A.B., Washington School, 1944. Scott R. Barrett, Jr., M.D., Howard University, 1960; M.D., University of Mitchell Yanow, M.D., Washington University, 1975. Missouri, 1964. University. 1941.

1 65 ophthalmologic examination and assists in the workup of Department of eye patients at St. Louis Veterans Administration Hospi- tal and at Washington University Medical Center(Barnes Hospital). He is expected to present cases at rounds and Ophthalmology conferences. This elective is geared to the student who plans to enter the specialty of ophthalmology. Instruction begins in the second year with methods RESEARCH ELECTIVES of examination of the eye. Emphasis is on the use of the Experimental and clinical research in glaucoma. ophthalmoscope. There are also several lectures on var- (Drs. Kass, Krupin) ious aspects of ocular disease. During the third year, Experimental and diagnostic ophthalmic pathology. students are assigned to an ophthalmology clerkship for (Dr. M. Smith) one week. In the fourth year, six-week and twelve-week clinical or research electives are offered. Experimental research in ocular physiology. (Dr. Moses) SECOND YEAR Research in cornea and diabetes. (Dr. Waltman) Ophthalmology Experimental research in anatomy and physiology. Lectures and demonstrations in the basic principles of (Dr. Cohen) ophthalmology. (Staff) Experimental research in visual physiology. THIRD YEAR (Dr. R. Miller) Ophthalmology Experimental neuropathology. (Dr. R. Burde) Students rotate through the Eye Clinic for a one-week Computer application in visual fields. (Dr. W. Hart) clinical clerkship. (Staff) Research in intraocular lenses. (Dr. D. Meltzer) FOURTH YEAR ELECTIVES Clinical research in pediatric ophthalmology. Clinical Clerkship in Ophthalmology (Dr. J. Miller) One student rotates through the Department of Oph- thalmology for either a six-week period or a twelve-week period. He is given instruction in the basic principles of

Faculty of the Department of Ophthalmology

Professor and Head of Department Robert A. Moses, A.B., Johns Hopkins Bernard Becker, A.B., Princeton University. 1938; M.D., University of University, 1941; M.D.. Harvard Maryland, 1942. University, 1944. Morton K. Smith, B.S., University of Maryland. 1956; M.D., 1960. (See IX-partmcnt of Pathology.) Professors Stephen R. Waltman, B.S.. Ronald M. Burde, B.S.. Massachusetts Massachusetts Institute of Technology, Institute of lechnology, I960: M.D.. 1961; M.D.. Yale University. 1964. Jefferson Medical College. NM. (See IX'partment of Neurology and Professors (Clinical) Neurological Surgery.) Robert C. Drews, A.B., Washington Adolph I. Cohen, U.S.. City College of University. 1952; M.D.. 1955. New York, 1948; M.A.. Columbia Kdward Okun, B.S.. Dartmouth University. 1950; Ph.D., 1954. College. 1952; M.D.. University of (See Department ol Anatomj Vermont. 1956. and Neurobiology.) Nigel \V. Daw, B.A.. Trinity College. Associate Professors 1956; M.A.. 1961; Ph.D.. Johns William M. Hart, Jr., Ph.D.. University Hopkins University, 1967. (Sec of Maryland. 1970: M.D.. 1970. Department of Physiology Michael A. Kass, B.S.. Northwestern and Biophysics.) University. 1966; M.D., 1966. Allan K. Kolker. A.B.. Washington Theodore Krupin, A.B., Washington University. 1954; M.D.. 1957. University. 1964: M.D., St. Louis James K. Miller, B.S.. Tulanc University. 1968. University, 1946; M.D.. the Medical Elsie F. Meyers, B.A.. Indiana College of Alabama. 1949. (Sec University. 1947; M.D.. 1950. (Sec Department of Pediatrics i Department of Ancsthesiology.)

(10 7

Robert F. Miller, M.D., University of Edward F. Berg, A.B., Washington Research Instructors Utah, 1967. (See Department of University. 1960; M.D., 1964. Mae E. Gordon, B.A.. Portland State Physiology and Biophysics.) Ronald C. Bilchik, B.S., University of University, 1967; M.S., University of Toledo, 1963; M.D.. Washington Wisconsin, 1970; Ph.D.. 1978. Associate Professors Emeriti (Clinical) University, 1967. Walter J. Grodzki, D.D.S., St. Louis Howard R. Hildreth, M.D., Washington James C. Bobrow, B.A., Yale University, University, 1944. University, 1928. 1966; M.D., Johns Hopkins Elaine Miller, A.B.. Judson College. Theodore E. Sanders, B.S., University University, 1970. 1944; M.D., Medical College of of Nebraska, 1931; M.D., 1933. Isaac Boniuk, U.S.. Dalhousic Alabama, 1949. (See Department University, 1958; M.D., 1962. of Pediatrics.) Associate Professors (Clinical) James H. Bryan, A.B., Washington Gillian Roper-Hall, D.B.O.. Moorfield George M. Bohigian, A.B.. Washington University, 1932; M.D., 1936. Eye Hospital, 1966; D.B.O.(D), 1969; University, 1961; M.D., St. Louis Dean B. Burgess, A.B., Occidental Certified Orthoptist, U.S. Board. 1973. University, 1965. College. 1963; M.D., University of Instructors (Clinical) Jack Hartstein, B.S.. University, of California, 1967. Nevinkumar J. Amin, l.S.C, Bombay Missouri, 1953; M.D., University of Samuel A. Canaan, Jr., A It. State University, 1960; M.B.B.S., 1966. Cincinnati, 1955. University of Iowa, 1942; M.A., Ruth S. Freedman, A.B., Washington Glen P. Johnston, A.B., Washington Columbia University. 1948; M.D., University, 1938; M.D., 1942. University, 1953; M.D., 1956. Meharry Medical College, 1954. David M. Freeman, A.B., University of Jack Kayes, B.A., Yale University, 1953; Richard F. Escoffery, MB.. B.S.. Missouri, 1940; B.S.,Med., 1941; M.D., M.D., Washington University, 1957. University of West Indies Medical Washington University, 1943. Terence G. Klingele, M.D., University of School, 1969. Sidney J. Hanish, B.A.. University of California, 1970. Robert M. Feibel, A.B., Johns Hopkins North Dakota. 1969; M.L.A., 1971; Benjamin Milder, M.D., Washington University. 1965; M.D.. Harvard M.D., Rush Medical College. 1975. University, 1939. University, 1969. Michael J. Isserman, A.B.. Harvard Harry D. Rosenbaum, M.D., James M. Gordon, B.A., University of University, 1971; M.D., Washington Washington University, 1934. Minnesota, 1962; M.D., 1966. University, 1975. Bernd Silver, B.S., University of M. Gilbert Grand, B.S., Tufts William S. Joffe, A.B., Washington Louisville, 1952; M.D.. 1956. University, 1964; M.D., Yale University, 1959; M.D., 1963. University, 1968. Robert L. Lamberg, B.S., University of Assistant Professors Harry L. Knopf, A.B., Harvard Missouri. St. Louis, 1972; M.D., David W. Meltzer, A.B., Princeton University, 1963; M.D.. Harvard Washington University, 1976. University, 1965; Ph.D., University of Medical School. 1967. John V. Linberg, B.A., University of Rochester, 1970; M.D./Ph.D., Barry D. Milder, B.S., Massachusetts Rochester, 1967; M.D., New York University of Miami. 1975. Institute of Technology, 1969; M.D.. University, 1971. Peter Reinach, B.S., New York Washington University, 1973. Robert Joseph Oik, A.B., Johns University, 1964; Ph.D., 1972. Matthew Newman, A.B., Vanderbilt Hopkins University. 1969; M.L.A., 1971; Malcolm M. Slaughter, B.S., City University, 1956; M.D.. Columbia M.D., Rush Medical College, 1975. College of New York, 1967; M.S., University, 1959. John C. Perlmutter, B.A., Queens Fordham University, 1972; Ph.D., 1977. F. Thomas Ott, B.A., Southern College, 1967; M.D., Cornell University Mitchel L. Wolf, B.A.. Yeshiva College, Methodist University, 1963; M.D.. Medical College, 1971. 1964; M.D., Albert Einstein College of Washington University, 1965. Maxwell Rachlin, M.D., University of Medicine, 1968. Lawrence T. Post, Jr., M.D.. Toronto, 1942. Washington University, 1948. Michael B. Rumelt, B.S., Lamar State Assistant Professors Emeriti (Clinical) Philip T. Shahan, A.B.. Harvard College of Technology, 1962; M.D.. Edmund B. Alvis, M.D.. Washington College, 1938; M.D., Washington Washington University, 1966. University, 1934. University, 1942. Mickey L. Salmon, M.D., Louisiana Daniel Bisno, B.A.. University of Arthur W. Stickle, Jr., M.D., University State University, 1959. Wisconsin, 1927; M.D., Johns Hopkins of Oklahoma, 1943. Assistant University, 1931. Philip Venable, B.S., Wayne State Clemens H. Jacques, B.S., University of William H. Meinberg, B.S., Washington University, 1935; M.D., 1940. California, 1949; O.D., 1949. (See University, 1932; M.D.. 1932. Charles E. Windsor, A.B., Carleton Medical Care Group.) College, 1956; M.D.. University of Research Assistants Assistant Professors (Clinical) Rochester. I960. Dorothy G. Cooper, R.N., Washington Neva P. Arribas, M.D., Manila Central Instructors University, 1953; B.S.N., 1964; University, 1954. Rodolfo Dumlao, B.A.. Far Eastern M.S.N., 1966. Stanley C. Becker, A.B., Washington University. 1959; M.D., 1964. Nels J. Holmberg, B.S., Oklahoma University. 1948; M.A., 1950; Ph.D., Lawrence A. Gans, B.A., Columbia State University, 1963; M.S., 1966. 1951; M.D.. Chicago Medical University, 1972; M.D., Case Western Floyce A. Scherrer, R.N., Washington School. 1955. Reserve University. 1977. University. 1960.

67 THIRD YEAR Department of Otolaryngology Clerkship Practical instruction in diagnosis and treatment. One Otolaryngology week. (Dr. Thawley) FOURTH YEAR ELECTIVES Otolaryngology is presented to students during their Structure and Innervation of Labyrinth (Dr. Bohne) sophomore, junior, and senior years. A clinical patho- Clinical Clerkship logic correlation lecture scries is presented to sopho- A six-week rotation which stresses outpatient diagno- mores. In the junior year, each student spends one week sis and management of ENT problems. Lectures, field on one of the services in East Pavilion or St. Louis trips, office practice, and operating room exposure round Veterans Administration. During this period there is out the rotation. Two students are accepted for each teaching at the bedside, in the operating room, and in the rotation. (Dr. Thawley) clinic, supplemented by daily afternoon lectures, grand RESEARCH ELECTIVES rounds on Thursdays, and an introduction to audiology Cytology, neurology, and histochemistry of membranous as well as to basic ENT research. labyrinth. (Dr. Bohne) Senior students who show a special interest may take Physiology of larynx. (Drs. Ogura, Harvey) a rotating elective in ENT suited to their interests. Some possibilities include research or clinical work. Ample Nasopulmonary physiology. (Dr. Ogura) research facilities and ongoing projects are available. Clin- Metabolism of the inner ear. Physiological and biochemical exposure could include oncologic diseases related to ical aspects. (Dr. Thalmann) the head and neck, otologic diseases, otoneurology, audi- Otoneurology labs. (Dr. Stroud) ology, or middle-ear surgery. Development of otic capsule and ossicles. (Dr. Bohne) SECOND YEAR Audiology. (Bob Loomis) Otolaryngology and Physical Diagnosis Clinical pathologic correlative lectures in otolaryngology are given to the entire class. (Dr. Thawley)

Faculty of the Department of Otolaryngology l.indhurg Professor and (hon.). Northwestern University, 1962; Head of Department Sc.D. (hon.). Washington University, Joseph II. Ogura, A.B.. University of 197.1. (See Department of Physiology California, 19.17; M.D.. 1941. and Biophysics.) (Also Central Institute for the Deal.) Professors Donald (J. Sessions, A.B.. Princeton Research Professors University, 1958; M.D., Washington Donald H. Eldridge, SB.. Harvard University, 1962. University, 194.1; M.D., 1946. (Also S. Kichard Silverman (Audiology). Central Institute lor the Deaf and AH, Cornell University. 19,1.1; MS. Faculty of Arts and Sciences.) Washington University. 19.18; Ph.D., Ira J. Hindi, (Audiology). New York 1942. (Also Central Institute lor the State College for Teachers (Albany), Deaf and Faculty of Arts and Sciences.) 1942; M.A.. Northwestern University, (Jershon J. Spector, A.B., Johns Hop- 194.1; M.A.. Harvard University. 1947; kins University, I960; M.D., University Ph.D.. 1948. (Also Central Institute of Maryland. 1964. for the Heat and faculty of Arts Malcolm II. Stroud, MB.. Ch.B., and Sciences.) 1 niversitv ol Birmingham, 1945; L.R.C.P.! M.R.C.S.. 1946; Professors Emeriti (Clinical) K.R.C.S.. 1949. Harold M. Cutler, A.B.. University of Kuediger Thalmann. M.D.. Maine, 19.10; M.D., Tufts College. 19.17. University of Vienna, 1954. Ben H. Senturia, A.B., Washington Research Professor Emeritus University. 19.11; M.D.. 1935. and Lecturer Hallowed Davis, A.B.. Harvard Professor (Clinical) I Diversity, 1918; M.D., 1922; Sc.D. Morris Davidson, B.S.. Indiana (hon.). Colby College. 1954; Sc.D. University. 19.16; M.D.. 1938. 68 I Associate Professors Assistant Professors (Clinical) John DeMott, B.A., University of Barbara A. Bohne, A.B., Washington Wallace P. Berkowitz, B.S., University Missouri, 1975; M.A., 1978. University, 1967; Ph.D., 1971. of Notre Dame, 1963; M.D., Boston Instructors (Clinical) University, 1967. Joseph E. Harvey (Experimental- Larry Dobbs, B.S., Hendrix College, Otolaryngology), B.A., University of Sheldon Davis, B.S., Wayne State 1968; M.D., University of Arkansas, I California, Berkeley, 1954; M.A., 1964; University, 1969; M.D., University of Medical Sciences, 1972. Ph.D., 1968. Michigan, 1973. Steven B. Overton, B.S., University of Stanley E. Thawley, B.A., University of Norman S. Druck, A.B., Washington Michigan, 1963; M.D., 1967; M.S., 1972. Texas, 1963; M.D., University of Texas University, 1967; M.D., University of Albert F. Ruehl, B.S., Washington Medical Branch, 1967. Illinois, 1970. University, 1961; M.S., 1964; M.D.. Jeffrey Fierstein, B.A., Dartmouth St. Louis University School of Associate Professors Emeriti (Clinical) College, 1967; M.D., Albert Einstein Medicine, 1973. William T. K. Bryan, A.B., Washington College of Medicine, 1971. University, 1929; M.D., 1933. Richard E. Schrick, B.S., University Donald R. Ingram, M.D., University of of Missouri, Rolla, 1968; M.S., Guerdan Hardy, M.D., Washington Illinois, 1956. University of Missouri. Columbia, 1972; University, 1929. Arnoldo Kuczer, M.D., University of M.D., 1977. Robert E. Votaw, B.S., State University Buenos Aires, 1955. (Jewish Hospital.) of Iowa, 1927; M.D., 1929. Research Associates Philip L. Martin, B.A., St. Louis William Clark, B.A., University of University, 1968; M.D., 1968. Associate Professors (Clinical) Michigan. 1969; M.S., 1973; Ph.D., Lloyd Thompson, B.A., Union College, Benard C. Adler, B.S.. Washington 1975. (Also Central Institute for University, 1937; M.D., 1937. 1960; M.D., Howard University, 1964. the Deaf). Supote Phipatanakul, M.D., Carl F. Ehrlich, B.S., St. Louis Nancy Marcus, B.S., Antioch I Chulalongkorn Hospital Medical University, 1961; M.D., University of College, 1968; M.A.. Washington School, 1965. Missouri, Columbia, 1965. University, 1970. Charles C. Jacobs, A.B., Washington Research Assistants University, 1942; M.D., 1945. Instructors Charles D. Carr Edward H. Lyman, B.S., Washington Harlan R. Muntz, B.S., Miami Gertraude Thallinger University, 1937; M.D., 1937. University Ohio, 1973; M.D., Consultants Wayne A. Viers, B.S., Phillips Washington University, 1977 (Jewish Daniel P. O'Brien, D.D.S., Washington Hospital). University, 1952; M.D., University of University, 1964. Oklahoma, 1956. Research Instructors L. Woodrow O'Brien, D.D.S., Joseph W. West, M.D., Duke Marion P. Bryan, A.B., Washington Washington University, 1935. University, 1944. University, 1931. Richard L. O'Brien, B.S., St. Louis Thomas H. Comegys, B.A., Central University. 1964; D.D.S., Washington A ssistant Professor Methodist College, 1966. University, 1968; M.S., 1973. Kenneth D. Faw., B.S., Seattle Pacific College, 1972; M.D., University of Washington School of Medicine, 1976. Laurence A. Levine, B.A., Hofstra University, 1962; M.A., 1963; D.D.S., New York University, 1967; M.D., Albany Medical College, 1971. (Jewish Hospital.) Peter G. Smith, B.S., Clemson University, 1967; Ph.D., Purdue University. 1972; M.D., Medical University of South Carolina, 1976.

Research Assistant Professor Daniel C. Marcus, B.S., Antioch College. 1968; M.S.. Washington University. 1971; D.Sc, 1976. Isolde Thalmann, B.S., Washington University, 1969; A.M., 1972.

Assistant Professors Emeriti (Clinical) Alfred J. Cone, B.S.. State University of Iowa, 1921; M.D., 1923; M.S., 1927. Herbert M. Smit, M.D., St. Louis I University, 1933.

69 Laboratory Medicine Conference Department of One hour each week for six weeks during Internal Medicine rotations at Barnes Hospital. Problem cases and general principles of Laboratory Medicine are Pathology discussed. (Staff)

Modern pathology is concerned with the molecular Tumor Conference and ultrastructural basis of disease. Historically, morpho- One hour each week for twelve weeks during the logic studies provided the foundations of our concepts of surgery and obstetrics and gynecology clerkships. Prob- disease, and ultrastructural studies continue to add to our lem cases are presented for illustration and discussion of understanding, but modern pathology utilizes virtually all all aspects of neoplastic disease. (Staff) of the tools of basic sciences. I'athologists are involved in diagnostic, leaching, and research activities. RESEARCH In addition to the sophomore year of pathology, the Bio 590. department conducts numerous combined conferences The department encompasses all of the major areas of which third- and fourth-year students attend as part of investigation in experimental pathology. Examples individual clinical clerkships. These are described below. include: Students, usually in their fourth year, may elect to Production of monoclonal antibodies against B participate in advanced courses or clerkships in autopsy lymphocyte. (Dr. Ahmed) or surgical pathology or laboratory medicine, or to pursue research in experimental pathology. Lymphokines: Structure and mechanisms of action. (Dr. Aune) The department offers a course of study leading to the Ph.D. degree. Medical students who desire to com- Examination of glycoprotein oligosaccharides and their bine graduate and medical programs of study should role in endocytosis and cellular recognition. consult Dr. Michael l.ieberman. (Dr. Baenziger) lor the purpose of teaching, research, and service, Kinetics and hormonal aspects of neoplastic cell growth. the department is divided into specialty divisions under (Drs. Bauer, Meyer) the folowing directors: Plasma membrane tumor associated antigens and immu- Autopsy Pathology. Dr. McKeel nity to them in human lung cancer. (Dr. Bell) Ciraduate Programs in Experimental Pathology, Mechanism of antigen recognition by cytolytic T Dr. Haenziger lymphocytes. (Dr. Braciale) laboratory Medicine, Dr. McDonald The possible role of insulin in the regulation of intracellu- Neuropathology, Dr. Nelson lar calcium homeostasis. (Dr. Chan) Pediatric Pathology, Dr. Kissane Experimental analysis of gastrin secretion by rat pyloric Surgical Pathology, Dr. W. Bauer antral cells in vitro. (Dr. DeSchryver) SECOND YEAR The coordination and interregulation of the pathways of Bio 515, 516. General Pathology carbon and energy metabolism in vitro using Escherichia This course is a comprehensive study of the cellular and coli as a model system. (Dr. Dietzler) molecular basis of disease. Lectures, gross and micro- Functional and biochemical characterization of human T scopic demonstrations, laboratory work, tutorials, case lymphocyte subpopulations and identification of human studies, and experimental pathology seminars are all immune response genes. (Dr. Gebel) utilized. The course is divided into six sections, each Structure and function of endocrine cells of the gastroin- consisting of a six-week period of study that is correlated testinal tract and pancreas. (Dr. Greider) with the subject matter concurrently presented in the Immunologic aspects of lymphoreticular disease. sophomore pathophysiology course. (Dr. Griffith) The sections consist of (I) general pathology and infec- Cellular immunology with particular emphasis on genetic tious diseases, (2) cardiovascular, pulmonary and renal control of antibody responses. (Drs. Kapp and Araneo) diseases, {}) metabolic, endocrine, and gastrointestinal diseases, (4) hematology and oncology, (5) neuropathol- Morphologic and immunocytologic correlates of pulmo- ogy. and (6) development, pediatric, obstetric, and gyne- nary disease. (Dr. Katzenstein) cologic diseases. (Staff) Renal pathology, pediatric pathology. (Dr. Kissane) THIRD AND FOURTH YEARS Rapid diagnostic methods for the detection of opportunistic systemic fungal infections. (Dr. Kobayashi) Clinical Pathological Conference The clinical history and treatment of patients who have Mechanism of antimicrobial action and resistance. died are discussed before the class by the physicians and (Dr. Krogstad) surgeons of the departments concerned. These confer- Experimental pulmonary diseases, environmental ences afford the students an opportunity to interpret the pathology. (Dr. Kuhn) clinical observations in light of the postmortem findings. Experimental diabetes mellitus, tissue culture of islets, One hour a week during the year. (Staff) transplantation of islets. (Dr. Lacy)

'0 Distribution of electrolytes and trace metals in blood. Autopsy Pathology (Dr. Ladenson) A full-time elective, periods 4-8. Students assist in per- Chemical carcinogenesis and enzymology of DNA repair, forming autopsies and participate fully in anatomic chromatin structure, DNA methylation and cloning. pathology research-related conferences, as well as in the (Dr. Lieberman) mechanisms of diseases journal club. Experimental diabetes: biochemical studies of insulin (Dr. McKeel and Staff) release mechanisms in vitro. (Dr. M. McDaniel) Selected Topics in Immunology Biology of breast cancer. (Dr. McDivitt) and Immunopathology This will be a seminar course covering topics in immu- Cellular mechanism of insulin and related hormone nology and immunopathology with emphasis both on action with emphasis on the role of intracellular divalent areas of current research interest in immunology and on cations. (Dr. McDonald) areas applicable to the understanding of human disease Human and experimental pituitary neoplasms: pathoge- states. The subject matter can be selected so as to suit netic mechanisms, cell biology, cytology, diagnosis and student interests but will also include organization of the treatment. (Dr. McKeel) immune system, immune deficiency and immunosup- Analysis of predictability of clinical laboratory diagnostic pression, cellular interaction in the immune response, tests. (Dr. Murray) patterns of immunological disease and diseases with Analysis of human lymphocyte subsets. (Dr. Nahm) immunological features, tolerance, and autoimmunity. Pathogenesis of cerebral microcirculatory injury: (Dr. T. Braciale) response of the autonomic nervous system to injury; Neuropathology Seminar pathology and pathogenesis of lesions associated with Clinical pathological correlations of neurological dis- vitamin E deficiency; pathogenesis of skeletal muscle eases will be investigated by the case study method using injury. (Dr. Nelson) current and documented material. Participants will par- take in gross neuropathological examinations and will be The application of biostatistics and computer technology to the solution of data analysis problems in Laboratory assigned selected cases for discussion of clinical data and Medicine. (Dr. Parvin) gross and microscopic pathological findings, especially in relationship to evolution and mechanism of disease pro- Mechanisms regulating immune responses in tissue cul- cesses. Topics covered will include vascular, infectious, ture systems. (Dr. Pierce) demyelinating, and neuronal diseases, as well as neo- Transplantation immunology. (Dr. Rodey) plasms of the nervous system. (Dr. Nelson) I The mechanism of adhesion to and activation of platelets Clinical Laboratory Medicine by collagen and the role of von Willebrand factor in this A full-time elective, periods three and five. Designed to process. (Dr. Santoro) acquaint the student with the proper use of the laboratory Metabolism of coagulation moieties (fibrinogen and in clinical medicine and to expose the student to the basic platelets), thrombus localization, and blood banking operation of each area of the laboratory. immunoassays. (Dr. Sherman) (Dr. McDonald and Staff) Relationships of high-energy phosphates and insulin Anatomic Pathology—Jewish Hospital action. (Dr. Siegfried) This elective is designed to reacquaint students who Placental transport and surface membrane structure and have had some clinical experience with the morphological function. (Dr. C. Smith) basis of disease, and to permit them to relearn normal Clinical microbiology, anaerobes, endogenous infections. morphological relationships. During the elective students (Dr. Sonnenwirth) will learn to perform gross autopsy dissections, and will Metabolic bone diseases. (Dr. Teitelbaum) be taught how to select appropriate tissue samples for further microscopic, histochemical, immunofluorescent Characterization of receptor ligand binding systems. and electron microscopy study. Subsequently, they will (Dr. Valdes) learn how to perform these procedures under supervision Pathogenesis of diabetic vascular disease. Cellular mech- of members of the Anatomic Pathology Staff and how to anisms of endocytosis and macromolecular transport by interpret their results. Following completion of approp- endothelium. (Dr. Williamson) riate studies, an in-depth report of clinical pathological Immunochemistry of fibrinopeptide. (Dr. Wilner) correlations will be prepared for each autopsy performed. This elective is considered appropriate for students who ELECTIVES intend careers in Internal Medicine, Surgery and Advanced Special Pathology Radiology. (Dr. McDivitt and Staff) A series of seminars discussing timely selected topics in Laboratory Medicine—Jewish Hospital special pathology of human disease, augmented by illus- Intensive elective training in Laboratory Hematology: trative cases and emphasizing clinicopathologic correla- Includes training in immunochematology, coagulation tions. Reading lists will be circulated and active discus- and special as well as routine laboratory hematology sion is encouraged. If the size of the group makes it procedures. Emphasis will be placed on laboratory proce- practical to do so, each student will prepare and conduct a dures and their relationship with patient diagnosis and session on a subject of his choice. (Dr. Kissane) management. (Dr. Wilner)

7! Surgical Pathology—Jewish Hospital The Division of Surgical Pathology also offers an This elective is designed to acquaint the student with Oncology course for a 6-week period under the guidance the discipline of Surgical Pathology and to permit him to of Walter C. Bauer, M.D. This elective is designed to develop basic skills in histopathological interpretation. expose the student to all aspects of neoplastic disease. This elective will be offered to only one student/ period in Students will follow the clinical course of a variety of order to permit maximum interaction with the Surgical cancer patients, correlating clinical response with mode of Pathology Stall and House Officers. During the course of treatment, state of disease, and pathologic evaluation. the elective, the student will be taught to function as a Students will make rounds with the medical oncologists junior House Officer. He will participate in the examina- and will follow treatment with surgery, irradiation and tion and dissection of gross specimens, take operating chemotherapy. Correlation of the results of radiologic room call, learn frozen section diagnosis, and formulate examinations, exfoliative cytology and tumor kinetic stu- histopathological diagnoses, all in conjunction with dies with extent of disease and response to treatment will members of the Senior Staff. Since the Laboratory of be studied. Students will represent in detail the treatment, Surgical Pathology at Jewish Hospital processes a broad rationale for therapy, and observed response on at least range of medical biopsy material as well as specimens one patient per week. (Dr. Bauer) derived from busy surgical subspecialty practice, the elec- In addition to the above, the department offers a tive is considered desirable for students who plan careers number of advanced courses in the Division of Biology in internal medicine and surgery as well as for those who and Biomedical Sciences. These courses are listed below, intend to enter the Held of pathology. (Dr. McDivitt) but are described in the offerings of the Division of Surgical Pathology Biology and Biomedical Sciences. Surgical pathology offers an elective for a 6-week Bio 504. Environmental Pathology period under Surgical Pathology I. Students participate fully in activities of the Division of Surgical Pathology Bio 518, 519. Pathology Research Seminar and they are responsible for dissection and description of Bio 520. Methods in Experimental Pathology gross specimens and microscopic diagnosis under super- Bio 521. Cellular Aspects of the Immune Response vision of the senior staff of the Division. Students attend morning conferences with the Director, surgical and med- Bio 544. Mechanisms of Neoplasia ical grand rounds, tumor and subspecialty conferences. In addition. Surgical Pathology II includes rotations through subspecialtics: Neuropathology. Hematopathol- ogy. Dermatopathology, ENT Pathology and Gyneco- Note—The number preceding the course title indicates that the course carries credit in the Graduate School of Arts and Sciences. logic Pathology. (Dr. Bauer and Staff)

Faculty of the Department of Pathology

Edward Mallinckrodl Professor and John M. Kissane, A.B., University of Carl W. Pierce, A.B., Colgate Head of Department Rochester, 1948; M.D., Washington University. 1962; M.D., University of Paul K. Ijicy, B.A.. Ohio State University. 1952. (See Department Chicago. 1966; Ph.D., 1966. (See University. 1945; MIX, 1948; M.S., of Pediatrics.) Department of Microbiology and 1948; Ph.D., University of Charles Kuhn, A.B.. Harvard Immunology.) (Jewish Hospital) Minnesota, 1955. University, 1955; M.D., Washington University, 1959. Heschel J. Raskas, B.S.. Massachusetts Professors Emeriti Michael Kyriakos, B.S., City College of Institute of Technology. 1962; Ph.D., I mimi V. Ackerman (Pathology and New York. 1958: M.D., Albert Einstein Harvard University, 1967. (See Surgical Pathology). A.B.. Hamilton College of Medicine. 1962. Department of Microbiology College. 1927: M.D.. University of Michael W. Lieberman, B.A.. Yale and Immunology.) Rochester. 1932. (Also Consultant) University. 1963; M.D.. University of Ruth Silberberg, M.D.. University of Pittsburgh. 1967; Ph.D., 1972. Glenn E. Rodey, B.S., Ohio University, Brcslau. 1931. (Also Lecturer) Robert W. McDivitt, M.D.. Yale 1957; M.D., Ohio State University, 1961. Medical School. 1956. (Jewish Hospital) (See Department of Medicine.) Professors John S. Meyer, A.B., Yale University, Walter C. Bauer. B.S., Ohio State 1952; M.D., Washington University, Laurence A. Sherman, B.A., B.S.. University. 1946; MIX, Washington 1956. (Jewish Hospital) University of Chicago. 1956; M.D.. University, 1954. James S. Nelson, M.D., St. Louis Albany Medical College, 1964. (See Joseph M. Davie, A.B.. Indiana University. 1957. (See Department Department of Medicine.) University. 1962; M.A.. 1964; Ph.D., of Pediatrics.) |96o; M IX. Washington University. John W. Olnev. B.A., Universitv of Morton E. Smith, B.S.. University of 1968 (See Department of Microbiology Iowa. 1956; M.D.. 1963. (See Maryland. 1956; M.D.. I960. (See and Immunology.) Department of Psychiatry.) Department of Ophthalmology.)

72 I

Alexander C. Sonnenwirth, A.B., Jay McDonald, B.S., Tufts University, Keith Fulling, A.B.. Johns Hopkins I University of Nebraska, 1950; M.S., 1965; M.S., Wayne State University, University, 1971; M.D.. Washington Purdue University, 1953; Ph.D., 1969. (See Department of Medicine.) University, 1975. Washington University, 1960. (See Carl H. Smith, B.A., Swarthmore Howard M. Gebel (Clinical Department of Microbiology and College, 1955; M.D., Yale University, Immunology), B.S.. University of I Immunology.) (Jewish Hospital) 1959. (See Department of Pediatrics.) Illinois, 1973; Ph.D., University of Richard Torack, B.S., Seton Hall Steven L. Teitelbaum, B.A., Columbia Missouri, 1976. (See Department University. 1948: M.D., Georgetown University, 1960; M.D., Washington of Medicine.) University, 1952. University, 1964. (Jewish Hospital) Deborah Gersell, B.S., University of Joseph R. Williamson, A.B.. Phillips George D. Wilner, B.S., Northwestern Michigan, 1971; M.D., Washington University, 1954; M.D., Washington University, 1962; M.D., 1965. (See University, 1975. University, 1958. Department of Medicine.) (Jewish Carlos J. Goldenberg, M.D.. Hospital) Universidad Nacional de Buenos Professor (Visiting Staff) Aires, 1967. Associate Professors (Visiting Staff) Frederick G. Germuth, Jr., A.B., Johns Rogers C. Griffith, B.S., University of Hopkins University, 1942; M.D., 1945. Frederick T. Kraus, B.A., College of William and Mary. 1951; M.D., Arkansas. 1968; M.D., 1972. Associate Professors Washington University. 1955. Suleyman Gulmen, D.D.S., Hacettcpe University, 1968; M.D.S.. University of Harish C. Agrawal, B.Sc. Allahabad William V. Miller, A.B., University of University, 1957; M.Sc, 1959; Ph.D., Missouri, 1962; M.D., 1966. (See Minnesota, 1972. (Also School of Dental Medicine.) 1964. (See Departments of Department of Medicine.) Pediatrics and Neurology and Blanca M. Perez, B.A., Universidad del Donald J. Krogstad, A.B.. Bowdoin Neurological Surgery.) Valle, 1953; M.D., 1961. College, 1965; M.D., Harvard Medical Jacques U. Baenziger, B.A., New School, 1969. (See Department College, 1969; M.D., Washington Assistant Professors of Medicine.) University, 1975; Ph.D., 1975. Jacques U. Baenziger, B.A., New Michael L. Landt, B.S.. Whitworth College, 1969; M.D., Washington C. Elliott Bell, Jr., B.S., Tulane College. 1970; Ph.D., University of University, 1975; Ph.D., 1975. University, I960; M.D., 1964. (See Oregon. 1976. (See Department Department of Medicine.) Thomas J. Braciale, B.S., St. Joseph's of Pediatrics.) College, 1968; M.D., University of David N. Dietzler, A.B., Washington Robert L. Low, A.B., University of Pennsylvania, 1975; Ph.D., 1975. University, 1957: Ph.D., 1963. (See California, 1970; Ph.D., University of Department of Medicine.) Kwok-Ming Chan, B.S., Hong Kong Chicago, 1975; M.D., 1977. Baptist College, 1971; Ph.D., University Milton N. Goldstein, B.S., Western Michael T. Mazur, B.S.. Northwestern of South Dakota, 1977. (See University. 1970; M.D., 1973. (Jewish Reserve University, 1946; M.S., 1947; Department of Medicine.) Ph.D., 1952. (See Department of Hospital) Anatomy and Neurobiology.) Katherine DeSchryver, M.D., University Daniel W. McKeel, B.S., Hampden- of Louvain, 1971. Marie H. Greider, B.S., Ohio State Sydney College. 1961; M.D.. University University, 1949; M.S., 1955; Samir K. EI-Mofty, B.D.S., Cairo of Virginia. 1966. Ph.D.. 1960. University, 1959; M.Sc, University of David N. Menton, B.S.. Mankato State Pennsylvania, 1966; Ph.D., Temple College, 1959; Ph.D., Brown University. Phyllis M. Hartroft, B.S., University of University, 1975. (Also School of Michigan. 1949; M.A., University of 1966. (See Department of Anatomy and Dental Medicine.) Toronto, 1951: Ph.D., 1954. Neurobiology.) Judith A. kapp-Pierce. B.A., Miami University, 1965; M.S., Indiana University, 1969; Ph.D., Harvard University, 1976. (See Department of Microbiology and Immunology.) (Jewish Hospital) Anna-Luise Katzenstein, A.B., Johns Hopkins University, 1968; M.D., 1971. Gerald Kessler, B.S., City College of New York. 1950; M.S.. University of Maryland. 1952; Ph.D.. 1954. (Jewish Hospital) Jack H. Ladenson, B.S., Pennsylvania State University, 1964; Ph.D., University of Maryland. 1971. (See Department of Medicine.) Michael L. McDaniel, B.A.. Southern Illinois University. 1963; M.S., University of North Dakota, 1966: Ph.D.. St. Louis University, 1970.

73 1'utrick Murray, U.S., Saint Mary's Moon-Shong Tang, B.S., National College, 1969; Ph.D., University of Taiwan University, 1966; M.S., California, 1974. (See Department University of Texas, 1975; Ph.D., 1976. of Medicine.) Ronald G. Tilton, B.S., University of Moon Nahm, AH., Washington South Florida, 1971; Ph.D., Washington University, 1970; M.D., 1974. (See University, 1977. Department of Medicine.) Instructors (Clinical) Daniel Santa Cruz, M.D.. University of Parveen Ahmed, M.B.B.S., Karachi Buenos Aires, 1971. University, 1970. Samuel Santoro, B.S., Emory Curtis Parvin, B.S.. Michigan State University, 1972: M.D., Vanderbilt University, 1974; M.S., University of University, 1979; Ph.D., 1979. (See Minnesota, 1976; Ph.D., 1980. Department of Medicine.) Instructors (Visiting Staff) Robert K. Schmidt, A.B., Washington University, 1969; M.D., 1976; Tomas Aquino, S.B., Santa Clara I'h. I)., 1976. Institute, 1949; M.D., University of Havana, 1957; Ph.D., University of Barry A. Siegfried, B.S., Washington Chicago, 1967. University. 1972; M.D., 1976. (See Robert R. Dahlgren, U.S.. Oklahoma Department ol Medicine.) (Jewish State University, 1962; D.V.M., 1963; Hospital) M.S., 1966. K. Kaye Smith, B.S., Webster College, Virgilio P. Dumadag, M.D., Far 1957; M.S., St. Louis University, 1963; Eastern University Institute of D.V.M., Kansas State University, 1965. Medicine, 1961. Koland Valdes, Jr., B.S.. University of Rodolfo A. Latorre, M.D., University of Miami, 1969; M.S.. California State the East, Ramon Magsaysay Memorial University, 1972; Ph.D., University of Medical Center, 1961. Virginia, 1976. (Jewish Hospital) Luis I umialan, M.D., University of Manuel Marban, A.A., Xavier Research Assistant Professor San Marcos, 1965. University, 1959; M.D., University of Kun-hwa llsieh, U.S.. National Taiwan Andres J. Valdes, B.S., Institute de Santo Tomas, 1964. University, 1965; Ph.D., University of Santa Clara, 1949; M.D., University of Michael A. McCarty, A.B., Washington California. 1973. (Jewish Hospital.) Havana, 1957. University, 1969; M.D., 1973. Instructors Carlos Perez-Mesa, M.D., University of Assistant Professors (Visiting Staff) Havana, 1950. Wagih M, Abdel-Bari, B.A.. School of Howard Brent Clark, B.A., Macalester College. 1970; M.D., Washington Antonio Salvador, M.D.. University of Science. 1948; M.D.. Ein Shams Porto, 1963. University, 1953; Ph.D.. Washington University. 1978; Ph.D., 1978. Ursula Sclafford, B.S.. Howard University. 1965. Jeffrey Saflitz, B.A., Case Western University, 1942; M.D., 1945. John D. Bauer, B.Sc, University of Reserve University, 1971; M.S., 1971; Gregorio Sierra, B.S., Institute of Innsbruck. 1938; L.R.C.P. and S.. Ph.D., 1977; M.D., 1978. Man/anillo, 1945; M.D., University of University of Glasgow, 1944; M.D., Research Instructors Havana, 1954. M.iiqucttc I imi'isiiv. |94 " Barbara A. Araneo, B.A., University of Luis Q. Del Rosario, M.D.. University Wisconsin, 1973; Ph.D.. University of Research Assistants of Santo Tomas, 1954. Rochester, 1976. (Jewish Hospital.) Maria Chraplyvy, B.S., St. Louis Valgard Jon.vson, B.S.. North Dakota Thomas M. Aune, B.S., Southwestern University, 1964; M.S., 1967. Slate University, 1958; M.S.P.H.. ut Memphis, 1973; Ph.D.. University of Dorothy J. Fiete, B.S., Marymount University of North Carolina. 1961; Tennessee, 1976. (Jewish Hospital) College, 1966. Ph.D.. 1965. Vivian Braciale, A.B., Cornell C. Joan Fink, B.A., Lindenwood Richard A. Kahn, AH, University of University. 1969; Ph.D.. University of College, 1958. Missouri. 1966; M.S.. 1968; Ph.D.. Pennsylvania, 1973. Mary P. Leckie, B.S., University of Georgetown University, 1972. Katherine C. Chang, B.S.. University of Toledo, 1967. Kathleen S. McLaughlin, B.S.. St. Taiwan. 1969; Ph.D.. University of Joan Lee, B.S., Taiwan Christian 1 mns I Diversity. I960; M.D.. Iowa, 1974. College. 1960; M.S., Oklahoma State Washington University, 1964. Edward H. Einke, B.S.. Washington University, 1967. Ruben W. Ogilvie, B.A . University of University. 1962. Christina L. Patke, B.A., St. Louis Utah. 1943; M.D., 1946. Jeffrey P. Lake, B.A., Washington and University, 1977. Donald J. Parker, B.S.. Duqucsne Jefferson College, 1971; M.S., Idaho Santiago Plurad, B.S., University of University, 1959; M.S.. 1964; Ph.D.. State University. 1973; Ph.D., Montana Philippines, 1952; M.S., Iowa State K.inv.iv State I Diversity, |9r.~ State University. 1977. (Jewish Hospital) University, 1962; Ph.D., University of Richard Payne, B.S.. Ohio University. Craig M. Sorensen, B.S.. University of Missouri. 1967. I960; M.D., Washington Illinois. 1976; Ph.D.. Washington Elaine V. Rieders, B.A.. Hunter University. 1963. University, 1980. (Jewish Hospital) College. 1948.

'4 7

THIRD YEAR Edward A clerkship of six weeks is scheduled, where the student Mallinckrodt participates in the following: 1. Care of inpatients, sharing responsibility with intern or resident. Department of 2. Daily ward rounds and bedside conferences with house staff and attending physician. Pediatrics 3. Special conferences on various facets of pediatrics. 4. Tutorial with junior faculty. The primary aim of the Department of Pediatrics in 5. Weekly grand rounds. the teaching program is to stimulate interest in develop- 6. Weekly case conference. mental biology, especially human growth and development, and to provide the student with a foundation suffi- FOURTH YEAR ciently comprehensive so that he will have an appreciation This year is devoted to elective time which may be spent of pediatric problems regardless of his future choice of a according to the individual preferences of the student, career in medicine. who may serve as an intern substitute or in the research The major clinical and research facilities are in the laboratory or combine clinical and laboratory work. The St. Louis Children's Hospital and the St. Louis Maternity following electives are offered: Hospital. The former has a bed capacity of 182, and Pediatric Cardiology accepts children through adolescence with all types of medical problems. Hospital admittances average 6,000 Clinical Elective—Inpatient The student works as a subintern and is assigned annually. The Pediatric Outpatient Division averages selected patients on the Pediatric Cardiology ward. about 70,000 visits a year. In the Medical Center the (Drs. Goldring, Hartmann, Hernandez, Strauss) yearly number of newborn infants averages more than 4,000. Clinical Elective—Outpatient The student will see patients attending all of the out- SECOND YEAR patient clinics including both new referrals and follow-up The student is introduced to pediatrics and to the visits. The student will also be responsible for the interpre- full-time staff through a series of lectures designed to tation of electrocardiograms, echocardiograms and 24- acquaint him with the concepts of human growth and hour Holter monitor examinations performed in the car- development, genetics, and the effects of age and maturity diology non-invasive laboratory. on reactions to injury and disease. A second series of talks (Drs. Goldring, Hartmann, Hernandez, Strauss) highlights the important disorders commonly encoun- Research Elective (minimum 12 weeks) tered in infants and children. The unique aspects of the Students will participate in on-going research concern- physical examination of the infant and child are presented ing the pathophysiology and epidemilogy of childhood during the course in physical diagnosis. Members of the hypertension (Dr. Goldring) or in the molecular basis of department also participate in the sophomore course in compartmentation of newly synthesized proteins (Dr. pathophysiology. Strauss). The basic science elective is conducted in the

75 i r i

Research Electives Research is aimed at identification of the proteins of Varicella Zoster Virus (VZV) and correlation of individual viral proteins with the antigenic determinants of humoral and some mediated host immune response to VZV infection. Prefer student for at least three periods who would like project leading to publication, but shorter projects could be arranged. Techniques involved are tissue culture, virus purification, immunofluorescence and ELISA assays, lymphocyte blastogenesis assays, gel elec- trophoresis radioimmune precipitation and affinity column chromatography. (Dr. Gardner) A variety of clinical and laboratory opportunities are available. The work is focused on H. influenzae type b infections in children—epidemiology, immune response and prevention through immunization. We are attempt- ing to delineate the composition and immunogenicity of the noncapsular surface antigens of this organism. We also are interested in genetic determinants of human antibody response to H. influenzae, type b. (Dr. Granoff) We are involved in studies of the humoral immune response of young children to polysaccharide antigens. Techniques utilized in these studies include isoelectric focusing, radioimmunoassays, affinity purification of antibodies and production of hybridoma antibodies. biochemistry department and involves recombinant (Dr. Shackelford) DNA technology, cloning of various DNA fragments and Pediatric Hematology and Oncology cell biological techniques. Large numbers of children with diverse hematological Pediatric Neurology and oncological problems are seen. During the six-week Clinical Klcctivc rotation the student will learn to interpret blood smears, 1 he student participates as a full member of the neu- bone marrows, and special laboratory studies. Concepts rology ward team and is directly responsible for a propor- of management and differential diagnosis are reviewed. tion of the patients on the service under the direction of (Drs. Brodeur, Distelhorst, Land, Vietti, Zarkowsky) the senior resident. He is expected to take night call every third or fourth night, during which time he is responsible Pediatric Renal Disease for the medical care of the entire ward, as well as for This course is designed to provide the student with a emergency admissions. (Drs. Dodge. Prensky) wide exposure to all aspects of pediatric renal disease and Research Klective an opportunity to explore a desired aspect of the field in I he student has an opportunity to learn some of the depth. The student will be an integral part of the Renal chromatographic and spectrophotometric techniques Team and as such will see a large number of both in- frequently used in developmental neurochemistry, while patients and outpatients. Students will have an opportun- working on a project of his choosing or one that is ity to follow the courses of patients with acute renal currently in progress in the laboratory. Prior discussion is disease as well as those with more chronic problems and necessary. (Dr. Agrawal) will help to plan the evaluation and therapeutic management of these patients. Discussions and rounds with the Pediatric Infectious Diseases attending staff and fellows emphasize the relationship Clinical Klective between clinical problems and the pathophysiology of the The student will be assigned patients on the Infectious underlying disease. These informal teaching sessions are Diseases or General Pediatric Division for initial evalua- supplemented by more formal sessions. These include tion and continuing care. The student works as an extern renal attending rounds, renal research rounds and journal and is expected to take night call every third night. Stu- clubs which are conducted weekly in conjunction with the dents work directly under the supervision of the senior Renal Divisions, Barnes and Jewish Hospitals. Formal resident and teaching rounds are conducted by the conferences are held regularly in association with Dr. faculty. The elective will provide experience in the man- John Kissane (renal pathology). Attendance at the weekly agement of many pediatric medical conditions including pediatric grand rounds and pediatric case conferences is a wide variety of infectious diseases, failure to thrive, encouraged. The student will be required to present one acute asthma, poisoning, immune deficiency diseases, or two in-depth reviews of areas of interest to him either in and gastrointestinal disorders. renal physiology or clinical topics. (Drs. Granoff. Keating. Shackelford) (Drs. Cole. Robson)

> I I

General Pediatrics Clinical Genetics Pediatric Ambulatory Service Six weeks, all day. Experience in clinical/laboratory A six-week course with participation in all aspects of approach to study of genetic problems. Students see all ambulatory care of children under the direction of St. consultations referred to the Division of Medical Genet- Louis Children's Hospital staff physicians. Includes diag- ics. They work in the Medical Genetics Clinic on Monday nosis and treatment of acute and chronic illness in general afternoons, attend daily genetics rounds, and participate pediatric service, in private physicians' offices, and in the in scheduled seminars. (Drs. Sly, Taysi) emergency room. Experiences in subspecialty clinics are Research Elective also offered. (Dr. Middelkamp) This course offers a period of research experience par- General Clinical Pediatrics ticipating in studies of I) lysosomal storage disorders, The student participates as an active member of the particularly mucopolysaccharidosis, and 2) fundamental pediatric care team at the St. Louis County Hospital. mechanisms of intracellular transport of macromolecules Under supervision of faculty, senior and junior residents, (receptor-mediated endocytosis). (Dr. Sly) he is involved with patients in the pediatric clinics, the emergency department, the newborn nursery, and the Neonatology inpatient service. The elective provides a general pediatric Clinical Neonatology experience, with emphasis on ambulatory care and The time is spent at St. Louis Children's Hospital in the neonatology. (Drs. Jones, Keller) intensive care nursery learning the care of severely ill Pediatric Endocrinology and Metabolism newborns and prematures. During the entire six weeks, This elective is designed to include broad clinical expe- daily teaching rounds will be held on the Intensive Care rience in pediatric endocrine and metabolic problems. Unit at Children's Hospital. Interested students may The student has the opportunity to evaluate many of the arrange to spend time at Maternity Hospital learning the pediatric endocrine patients and to see some adult examination and care of normal newborn and premature patients during weekly rounds. Emphasis is placed on the infants, as well as those with less severe illnesses that do practical management of common problems. The student not require intensive care. Students will be offered con- attends rounds and clinics (endocrine, metabolic, and siderable responsibility in patient care and may partici- diabetic) and the joint metabolic seminar and rounds held pate in the transportation of ill patients from other hospi- with the medical service. A large number of patients with tals to St. Louis Children's Hospital. Opportunities are varied problems are studied in depth during any six-week available for clinical research in perinatal medicine. period. (Drs. Bier, Blethen, Granoff, Hillman, (Drs. Hillman, Marshall, Thach) Santiago, Weldon, White) Genetics Seminar Elective Medical Genetics Developmental Neurobiology Twelve weeks, all day. Combined clinical and research This course covers selected topics in the development of course. (Drs. Sly, Taysi) the nervous system. While emphasis is given to the neuro- chemical aspects of brain growth and maturation, there are also discussions of the neurophysiological and functional development of the brain. The relationship between chemical, physiological, and functional development and underlying anatomical changes is stressed. The course is conducted as a seminar, with papers assigned prior to each meeting. Members of the Departments of Pediatrics and Neurology and Neurological Surgery are present at these discussions to clarify obscure points and to add additional information when possible. (Dr. Agrawal)

Clinical Chemistry Laboratory Research Electives Placental amino acid transfer—in vitro tissue incuba- tion, regulation, and relation to needs of the fetus. Com- position and function of trophoblast plasma membrane. (Dr. Smith) The role ofcalmodulin (an ubiquitous calcium-binding protein) in the mechanisms of hormone action. Present investigations include the involvement of calmodulin in (1) pancreatic islet cell secretion, (2) control of membrane phosphorylation, and (3) activation of hormone-sensitive enzymes. (Dr. Landt)

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Faculty of the Department of Pediatrics

Professor and Head of Department Richard E. Hillman, A.B.. Brown James S. Nelson, M.D., St. Louis I'hilip R. Dodge. M.D.. University of University, 1962; M.D., Yale University, University, 1957. (See Department Rochester. I94N. (See Department of 1965. (Sec Department of Genetics.) of Pathology.) Neurology and Neurological Surgery.) I-awrence I. Kahn (Health Care Alan M. Robson, M.B.B.S., University Allen P. and Josephine B. Green Research). A.B., University of Alabama, of Durham, 1959; M.D., 1964. (See Professor of Pediatric Neurology 1941; M.D., Louisiana State University, Department of Medicine.) 1945. (See Department of Preventive Arthur I.. Prensky. A.B.. Cornell William S. Sly, M.D., St. Louis Medicine and Public Health and University, 1951; M.D., New York University. 1957. (See Departments of Medical Care Group) (Also Pediatric University, 1955. (See Department of Medicine and Genetics.) Nurse Practitioner Program.) Neurology and Neurological Surgery.) James P. Keating, A.B.. Harvard Carl H. Smith, B.A.. Swarthmore Professor Emeritus University. 1959; M.D., 1963. College, 1955; M.D., Yale University, 1959. (See Department of Pathology.) Donald 1.. Thurston, B.S.. Vandcrbilt John M. Kissane, A.B., University of University, 1934; M.D., 1937. Rochester, 1948; M.D.. Washington Jessie L. Ternberg, A.B.. Grinnell (Also Lecturer.) University, 1952. (See Department College, 1946; Ph.D., University of Professors of Pathology.) Texas, 1950; M.D., Washington Harbin C. Agrawal, B.Sc. Allahabad Richard K. Marshall, B.A.. Wesleyan University. 1953; Sc.D. (hon.), Grinnell University, 1957; M.S.. 1959; Ph.D., University. 1954; M.D.. Yale College, 1972. (See Department of Surgery.) 1964 (Sec Departments ol University, 1962. Neurology and Neurological Surgery William H. McAUster, B.S., Wayne Jean H. Thurston, B.A.. University of and Pathology.) State University. 1950; M.D., 1954. (See Alberta, 1938; M.D., 1941. David Goldring. A.B.. Washington Department of Radiology.) Teresa J. Vietti, A.B.. Rice University, University, 1936; M.D.. 1940. J. Neal Middelkaiup, B.S.. University of 1949; M.D., Baylor University, 1953. Alexis K. Hartmann, Jr., B.S.. Missouri. 1946; M.D.. Washington (See Department of Radiology.) Washington Utmersitv. 194". University. 1948. Joseph J. Volpe, B.A.. Bowdoin College, Ml). 1951. James E. Miller, B.S., Tulane I960; M.D.. Harvard University. 1964, John C. Herweg, B.S.. Drury College. University. 1946; M.D.. Medical College (See Departments of Neurology and I»4V Ml)., Washington University. of Alabama. 1949. (See Department Neurological Surgery and Biological 1945. (See Administration.) of Ophthalmology.) Chemistry.) 78 L T

Clarence S. Weldon, A.B., University of Charles B. Manley, Jr. (Genitourinary Maurice J. Lonsway, Jr., A.B., Michigan, 1951; M.D., Johns Hopkins Surgery), A.B., University of Missouri, Washington University, 1946; University, 1955. (See Department 1955; M.D., 1958. (See Department M.D., 1950. of Surgery.) of Surgery.) John C. Martz, A.B., University of Virginia V. Weldon, A.B., Smith Helen Palkes (Psychology), B.S., Missouri, 1938; M.D., Washington College. 1957; M.D., University of Washington University, 1966; University. 1942. Buffalo, 1962. (See Administration.) M.A., 1968. Helen E. Nash, A.B.. Spelman College. Julio V. Santiago, B.S., Manhattan 1942; M.D., Meharry Medical Professors Emeriti (Clinical) College, 1963; M.D.. University of College, 1945. Joseph C. Jaudon, A.B., Washington Puerto Rico, 1967. (See Department Frederick D. Peterson, A.B., Knox University, 1926; M.D., 1933. of Medicine.) College, 1953; M.D., Washington Park J. White, A.B., Harvard Gary D. Shackelford, B.A., University, 1957. University, 1913; M.D., Columbia Northwestern University, 1964; M.D., Warren G. Sherman, B.A., University of University, 1917. Washington University, 1968. (See Missouri, 1965; M.D., Tulane Department of Radiology.) University, 1969. Professors (Clinical) Penelope G. Shackelford, B.S., Argyrios A. Tsifutis, M.D., Aristotelion University of Wisconsin, 1964; M.D., Maurice J. Keller, A.B., Yale University, University of Thessalonika, 1954. Washington University, 1968. 1936; M.D.. Columbia University, 1940. Frank S. Wissmath, A.B., Washington Arnold W. Strauss, B.A., Stanford George Sato, M.D.. Washington University, 1939; M.D.. 1943. University, 1966; M.D., Washington University. 1947. University, 1970. (See Department of Donald B. Strominger, B.A., Yale Biological Chemistry.) University, 1948; M.D., Washington Assistant Professors University, 1953. Kutay Taysi, M.D., Ankara University School of Medicine, 1961. Stephen J. Barenkamp, B.A., Carleton University, 1973; M.D., University of Associate Professor Emeritus Bradley T. Thach, A.B., Princeton Chicago, 1977. University, 1964; M.D., Washington Dorothy J. Jones, A.B., Oberlin University, 1968. Mary G. Beale, B.A., Wellesley College, College, 1930; M.D., Washington 1966; M.D., Johns Hopkins University, 1934. (See Pediatric Nurse James K. Turner, A.B., Washington University, 1970. Practitioner Program.) (Also Lecturer.) University, 1949; M.D., 1953. (See Medical Care Group.) Martin J. Bell, B.A., New York University, 1959; M.D., State University Associate Professors Harold Zarkowsky, A.B., Washington of New York, Downstate, 1963. (See University, 1957; M.D., 1961. Dennis M. Bier, B.S., LeMoyne College, Department of Surgery.) 1962; M.D., New Jersey College of Sandra L. Blethen, B.S., University of Medicine, 1966. (See Department Associate Professors Emeriti (Clinical) Chicago, 1961; Ph.D., University of of Medicine.) Helen M. AIT, B.S., Washington California, Berkeley, 1965; M.D., Albert Barbara R. Cole, B.A., Doane College, University, 1934; M.D., 1934. Einstein College of Medicine, 1975. 1963; M.D., University of Kansas, 1967. Max Deutch, M.D., Washington Richard J. Bower, B.S., Northern Ruthmary K. Deuel, B.A., Mount University, 1926. Illinois University, 1965; M.D., Holyoke College, 1956; M.D., Columbia Stanley L. Harrison, B.S., Washington University of Virginia, 1969. (See University College of Physicians and University, 1928; M.D., 1930. Department of Surgery.) Surgeons, 1961. (See Department of Frederick A. Jacobs, B.S., Washington Garrett M. Brodeur, B.A., St. Louis Neurology and Neurological Surgery.) University, 1927; M.D., 1928. University, 1971; M.D., Washington W. Edwin Dodson, A.B., Duke University, 1975. Sol Londe, B.S., Washington University, University, 1963; M.D., 1967. (See 1925; M.D., 1927. Max H. Burgdorf, A.B., Washington Department of Neurology and University, 1970; M.D., 1974. (See Neurological Surgery.) Bernard Schwartzman, A.B., Washington University, 1931; Medical Care Group.) Dan M. Granoff, B.A., Johns Hopkins M.D., 1935. James E. Carroll, B.S., University of University. 1965; M.D., 1968. Louisville, 1966; M.D., 1969. (See Barbara M. Herjanic, B.A., Department of Neurology and Northwestern University, 1943; B.S., Associate Professors (Clinical) Neurological Surgery and Irene Walter Western Michigan College, 1946; M.D., C. Read Boles, A.B., Washington Johnson Institute of Rehabilitation.) University, 1940; M.D., 1943. University of Michigan, 1950. (See Fred I. Chasalow, B.S., Stevens Institute Department of Psychiatry.) Robert H. Friedman, M.D., of Technology, 1964; Ph.D., Brandeis Antonio Hernandez, Jr., A.A., Washington University, 1948. University, 1971. University of the Philippines, 1949; Gene H. Grabau, B.S., St. Louis Milton L. Cobb, B.A., Baylor M.D., Manila Central University, 1954. College of Pharmacy. 1937; M.D., University, 1964; M.D., University Laura S. Hillman, B.A., Carleton Washington University, 1942. of Texas Southwestern Medical College. 1964; M.D., Yale Marshall B. Greenman, B.S.. University School, 1968. (See Department of University, 1968. of Illinois. 1946; M.D., 1948. Anesthesiology.) Vita J. Land, B.S.. McGill University, Kenneth A. Koerner, A.B., Washington Clark W. Distelhorst, B.A., Ohio State 1961; M.D.. 1965. University, 1935; M.D.. 1941. University, 1968; M.D., 1971. 1 79 Kelton .1. Earls, U.S., Howard Research Assistant Professors Paul H. Painter, M.D.. St. Louis University. 1963; M.D., 1967. (See Ronald I.. Gingerich, B.A.. Goshcn University. 1947. (See Division of Department of Psychiatry.) College, 1970; Ph.D., Indiana Child Psychiatry.) Kenneth D. law, US., Seattle Pacific University, 1975. (See Department Susan Pittman, A.B.. University of University, 1972; M.D., Washington of Medicine.) Missouri, 1959; M.D., 1963. University, 1976. (See Department of Robert S. Munson, B.A., University of Steven I. Plax, A.B.. University of Otolaryngology.) Connecticut, 1968; Ph.D.. 1976. Missouri, 1957; M.D., 1961. Tessa D. (Gardner, U.S., Massachusetts William J. Ross, B.A.. Miami Institute of Technology, 1968; M.D., Assistant Professors Emeriti (Clinical) University, 1968; M.D., Washington Harvard University, 1972. Martin Calodney, B.S.. College of the University, 1972. Alice B. (.runoff, HA, University of City of New York. 1930; M.D., New Robert C. Schaan, A.B., Washington lexas, Austin, 1959; M.D., University of York University, 1936. University, 1949; M.D., 1953. Texas Southwestern Medical Marianne Kuttner, M.D.. Johann Alfred S. Schwartz, A.B.. Amherst School, 196.1. Wolfgang Goethe University. 1931. College, 1932; M.D.. Johns Hopkins Gary E. Hirshbcrg, AH.. Princeton Kdith C. Robinson, A.B.. Randolph- University. 1936. University, 1968; M.D., Hahncmann Macon College. 1927; M.S.. University Mary A. T. Tillman, M.D.. Howard Medical College, 1972. (See Department of South Carolina, 1928; M.D., Johns University, 1960. of Ancsthcsiology.) Hopkins University, 1932. George T. Wilkins, Jr., B.S., University Barbel lloltmann, B.S.Ed., A.B., of Illinois, 1956; M.D., 1957. University of Missouri. 1964; M.D.. Assistant Professors (Clinical) 1968. (Sec Department of Surgery.) Edward T. Barker, A.B.. Princeton Kathleen Winters, B.S., Winthrop University, 1953; M.D.. Washington College, 1946; M.D.. Medical College of Mary I. Johnson, B.S.. Washington South Carolina, 1955. State University, 1964; M.D.. Johns University, 1957. Gerald Wool, A.B.. Princeton Hopkins University. 1968. (Sec Walter F. Benoist, A.B.. University of University. 1958; M.D., Washington Departments of Anatomy and Pennsylvania. 1968; M.D., Washington University, 1962. Neurobiology and Neurology and University. 1972. Neurological Surgery.) Gordon R. Bloomberg, A.B., University Instructors Michael I.. Landt (Laboratory of Illinois, 1955; B.S.. 1955; M.D., 1959. Suzanne G. Busch (Psychology), A.B., Medicine). U.S.. Whitworth College. James M. Corry, B.S., Grinnell College, University of Maryland, 1969; M.A., 1970; Ph.D., University of Oregon, 1976. 1970; M.D.. Washington Washington University. 1976; Ph.D., (Sec Department of Pathology.) University, 1974. 1981. Jeffrey I.. Marsh, B.A., Johns Hopkins Charles H. Dougherty, A.B.. College of John Gilster, (Dental Medicine). University, 1967; M.D., 1970. (Sec the Holy Cross, 1969; M.D., University D.D.S., Washington University, 1944. Department of Surgery.) of Rochester. 1973. Donald V. Huebener (Dental Medicine), Mabel I . Purkcrson. A.B.. Erskine Gerald J. Duling, B.S.. Xavier D.D.S., Washington University. 1969. College. 1951; M.D.. Medical College of University. 1955; M.D.. St. Louis (See Department South Carolina. 1956. (See University, 1959. of Radiology.) Administration and IX-partment Ira J. Friedman, B.S., University of M. Emin Kiyanclar, M.D.. Ain-Shams of Medicine.) Arkansas, 1955; M.D., I960. University, 1970. (See Department of Jerry I.. Kosenblum, B.A., Emory Elliot F. Oilman. B.A., State University Anesthesiology.) University. 1970; M.D., Washington of Iowa. 1957; M.D., University of Michael J. Noetzel, A.B., Yale University. 1974. Missouri. 1961. University, 1973; M.D.. University of Steven M. Rothman, M.D., State Samuel W. Gollub. B.S., Washington Virginia. 1977. University of New York. Upstate. 1973. University, 1941; M.D., 1941. Patricia A. Parsons (Dental Medicine), (See IXpartnicnts ol Anatomy and Santosh Gupta, M.B.B.S.. Lucknow B.S.. San Diego State College. 1953; Ncurobiology and Neurology and University. 1963; D.C.H.. University of D.D.S., Washington University. 1957. Neurological Surgery.) London. 1966. Barbara K. Talent (Psychology). B.A., Marilyn J. Siegcl, A H . Washington J. I-arry Harwell, A.B.. Washington DePauw University. 1972: Ph.D.. University. 1965; M.D.. State University University. 1958; M.D., University of Washington University. 1978. of New York. Downstate. 1969. (See Missouri. 1961. Zila Welner, M.D.. Hebrew University, IX-partment of Radiology.) Henry I.. Knock, A.B.. Johns Hopkins 1961. (See Department of Psychiatry.) Paul S. Simons, HA. University of University. 1949; M.D.. 1953. Instructor Emeritus (Clinical) lexas. 1963; M.D.. Washington Stanley B. Lyss, A.B.. Harvard Joseph A. Bauer, M.D.. Washington University. 1967. (See Medical University. 1958: M.D. Washington University. 1926. Care Croup.) University. 1962. Gregory A. Storch, AH. Harvard Richard Margolis, B.S.. College of Instructors (Clinical) University. 1969; M.D.. New York William and Mary. 1947; M.D.. Christos A. Antoniou, M.D.. University University School of Medicine, 1973. Western Reserve University. 1951. of Athens. 1958. Neil H. White, B.S.. Slate University of Homer E. Nash, Jr., B.S.. Morehousc Jean M. Auguste, B.A., Lycee T. New York. Albany. 1971; Albert College. 1948; M.D.. Mcharrv Medical LXJuverture. 1950: M.D.. Medical Fin-stein College of Medicine. 1975. College. 1951. School of Haiti, 1956.

SO Jill M. Baer, B.S., University of Robert L. Quaas, B.A.. Syracuse Kentucky, 1972; M.D., 1975. University. 1965: B.S.. University of Susan L. Baumer, B.A., University of South Dakota, 1973; M.D., University Oregon, 1969; M.D.. University of of Chicago. 1975. Pennsylvania. 1975. Mohammad H. Rahman, M.B.B.S.. Pardeep Bhanot, M.B.B.S., Medical University of Karachi. 1960. College of Amritsar. 1974. Richard W. Sato, B.A.. Johns Hopkins Huldah C. Blamoville, B.S.. Queens University. 1973: M.D., Washington College, 1959; M.D., Meharry Medical University. 1977. College, 1965. Howard J. Schlansky, B.A. University Carmelita V. Britton, B.S., Rensselaer of Missouri. Kansas City, 1976; M.D., Polytechnic Institute, 1973; M.D., 1978. Albany Medical College, 1973. Seymour M. Schlansky, M.D., Chicago Sandra J. Dodson, B.S., Cornell Medical School, 1950. University. 1970; M.D.. Northwestern Jeffrey I. Schulman, B.A.. Yale University. 1976. University. 1970: M.D., University of Florentina U. Garcia, M.D.. University Kentucky. 1974. of the Philippines. 1965. Karen L. Scruggs, B.A., Macalester Roman E. Hammes, B.A.. University of College. 1968: M.D., Washington Iowa. 1950: M.D.. 1954. University, 1973. Jay L. Hoecker, B.A.. Westminster Orestes S. Valdes, B.S.. Instituto de College. 1968: M.D., University of Santa Clara. 1947; M.D., University of Texas, 1973. Havana, 1954. Nancy E. Holmes, B.A., University of Barbara N. Voege. B.S., University of Kansas. 1972; M.D.. University of Illinois. 1950; M.D., Washington Missouri, 1976. University. 1957. Carl S. Ingber, A.B.. University of Roger J. Waxelman, A.B., Washington Rochester, 1968; M.D., Boston University. 1965; M.D., University of University, 1972. Missouri. 1969. Larry A. Jones, A.B., Johns Hopkins Patricia B. Wolff, B.A., University of University. 1972; M.D., 1976. Minnesota. 1968: M.D., 1972. (See Medical Care Group.) Sheldon Kessler, M.D.. St. Louis University, 1951. H. Benjamin Zwim, M.D., University Hospital. 1971; M.S.N.. St. Louis of Basel. 1954. Norton S. Kronemer, A.B., Washington University. 1978; (Also Pediatric Nurse University, 1958; M.D., University of Assistants Practitioner Program.) Missouri. 1962. Marion H. Baker, (Health Services), Research Assistants Leland M. Laycob, A.B., Washington R.N., St. John's Hospital. 1946; P.N.P.. Charles E. Crawford, Jr., B.S.. University, 1964; M.D., University of Cardinal Glennon Memorial Hospital Washington University. 1956. Missouri. 1968. for Children. 1973. (See Medical Charles A. Reed, A.B.. Washington Richard L. LazarofT, B.A., Brown Care Group.) University, 1961. University. 1974; M.D.. St. Louis Jeanette M. Broering, (Health Services), Lorraine L. Thomas, A.B.. St. Louis University, 1978. B.S.N.. St. Louis University, 1974; University. 1971: M.S.. Southern Illinois Despine Liebhaber, B.A.. Smith P.N.P.. Cardinal Glennon Memorial University. 1973. College. 1958; M.D.. Columbia Hospital. 1976. (See Medical Assistants (Clinical) University. 1962. Care Group.) Marietta O. Belen, M.D.. Far Eastern Susann M. Farberman, (Health Robert D. Lins, A.B.. University of University, 1963. Missouri. 1965; M.D., 1969. Services). R.N., B.S., St. Louis University. 1970: P.N.P., Washington Richard J. Iken, B.A., University of Elaine Miller, A.B., Judson College, Wisconsin. 1973; M.D.. University of 1944; M.D., Medical College of University. 1975. (Also Pediatric Nurse Practitioner Program.) Missouri. Columbia. 1978. Alabama. 1949. (See Department of Sudhir R. Raikar, MB.. University of Ophthalmology.) Susan K. Keating, (Health Services). B.S.. University of North Carolina Bombay. 1969. Alan M. Muney, Sc.B.. Brown Hsin-Chin Shih, M.D.. Kaoshiung University. 1975: M.D., 1978. School of Nursing, 1965; P.N.P., Washington University. 1970. Medical College. 1964. Michael J. Nichols, B.A., Brown Kevyn F. Schroeder (Health Services). Nareshkumar Solanki, B.M.. B.S.. University, 1973; M.D., 1976. B.S.. St. Louis University. 1975; P.N.P., University of Nairobi. 1975. David S. Olander, A.B.. Washington Washington University. 1976. Lecturers University. 1964: M.A.. 1965; Ph.D.. Mary J. Stralka, (Health Services). Dorothy J. Jones, A.B.. Oberlin 1967; M.D.. 1974. R.N.. Holy Cross School of Nursing. College. 1930; M.D.. Washington Eugenia M. Pierce, M.D.. St. Louis 1966; B.S.N.. St. Louis University. 1970; University. 1934. (Also Pediatric Nurse University. 1958. P.N.P.. Cardinal Glennon Memorial Practitioner Program.)

XI ] ] Secretion of macromolecules. Serum albumin biosynthe- Edward sis and secretion. (Dr. Geller) Purification and properties of the drug metabolizing enzymes. Glutathione dependent enzymes of metabolism ] Mallinckrodt and detoxication. (Dr. Hunter) The biosynthesis and chemical and biological characteri- Department of zation of leukotrienes and other arachidonate metabolites. (Dr. Jakschik) ] Pharmacology Normal and abnormal development of the sympathetic nervous system; physiology and pathophysiology of the sympathetic nervous system. (Dr. Johnson) It is the purpose of the pharmacology course, Mechanism of insulin action in regulating the phosphory- through discussions of existing drugs, to develop general ] lation of glycogen synthase in cultured mammalian skele- principles which will he applicable as well to drugs of the tal muscle cells. (Dr. Lawrence) future. Pharmacology draws heavily on biochemistry, physiology, and microbiology for an understanding of Neurochemistry; regulation of metabolism; quantitative drug action. It looks toward pathology, medicine, and histochemistry; the chemistry of individual human and ] muscle fibers. (Dr. Lowry) surgery lor its uses. The laboratory portion of the course is closely coor- Pineal-hypothalamic pituitary interactions in the regula- dinated with the lecture material and is designed to dem- tion of pituitary function. (Dr. Martin) onstrate and emphasize pertinent pharmacological prin- Energy metabolism in nerve, axonal flow, and the bio- ] ciples and to employ agents, equipment, and skills chemistry of sensory neurons. (Dr. McDougal) relevant to current medical practice. Regulation of endogenous renal hormones and their A selection of mini-courses (Special Topics), dealing effects on renal blood flow and excretory function. in depth with more advanced concepts of pharmacology (Dr. Morrison) ] and related topics is integrated into the medical pharma- Pharmacology and biochemistry of prostaglandins, cology course. Small groups of students regularly meet thromboxanes and prostacyclins. (Dr. Needleman) with the faculty to review and discuss the details and Biology of cytotoxic lymphocytes and mechanisms of interpretation of original literature articles. immune damage. (Dr. Russell) ] SECOND YEAR Pharmacology and biochemistry of neurotransmission in the basal ganglia. (Dr. Wooten) Bio 507, 508. Pharmacology (a) I ectures, conferences, panel discussions, (b) Labor- ELECTIVES ] atorv course. Credit 7 units for the vear. Bio 364. Principles of Drug Action (Dr. Covey and Staff) A brief study of pharmacology and pharmacodynam- RKSKARCH ics. This course discusses the biological, chemical, and Bio 590. molecular basis of action of drugs in general and of ] I he facilities of the research laboratories are available selected specific drugs in detail. Topics covered will to those who wish to carry on an original investigation on include general pharmacologic principles; receptor the- problems of their own or on those the department is ory; drug kinetics; distribution and metabolism; drugs prepared to suggest. which inhibit cellular growth, e.g., antibiotics, anticancer; endocrine drugs; both the autonomic and central ] Neurochemistry; regulation of metabolism; quantitative action of drugs; drugs which act on the cardiovascular histochemistry; micro-analytical methods. (Dr. Berger) and renal systems; and elements of psychoactive drugs Biosynthesis and processing of placental and pituitary and of drug abuse. (Dr. Johnson and Staff) peptide hormones. (Dr. Boime) Descriptions of the following courses are shown in the ] Problems in the biochemical development of rat kidney- Division of Biology and Biomedical Sciences: transport mechanisms in rat kidnev; renal histochemistry. (Dr. Burch) Bio 5031. Endocrine Physiology and Pharmacology. Experimental analysis of mechanisms of dysrhythmia; Bio 509, 510. Current Topics in Pharmacology ] electrophysiology; membrane chemistry and autonomic Bio 540. Cell Surface Receptors neural effects. (Dr. Corr) Bio 555. Neuropharmacology Synthesis and biological characterization of "suicide sub- strates" as potential inhibitors of androgen and estrogen ] biosynthesis in normal and carcinogenic tissue. Com- puter-assisted drug design. (Dr. Covey) Neurochemistry of seizures; neuropharmacology of anti- coin ulsant and psychotropic drugs; role of cyclic nucleo- Note—The number preceding the course title indicates that the tides in nervous tissue function and metabolism. course carries credit in the Graduate School of Arts and ] (Dr. Ferrendelli) Sciences. s: ] T

Faculty of the Edward Mallinckrodt Department of Pharmacology

Professor and Head of Department John H. Russell, B.S., Juniata College. Research Assistant Professors Philip Needleman, B.S., Philadelphia 1968; Ph.D.. Washington Sosamma J. Berger, B.S., University of College of Pharmacy and Science, 1960: University, 1974. Bombay, 1958; M.S., University of M.S., 1962; Ph.D., University of George F. Wooten, Jr., B.A., Rice Puget Sound. 1962; Ph.D.. Hahnemann Maryland. 1964. University, 1965; M.D., Cornell Medical College, 1968. Distinguished Professor Emeritus University Medical College, 1970. (See Sr. Barbara A. Jakschik, B.S.. and Lecturer Department of Neurology and Duquesne University, 1963; M.S., 1965; Neurological Surgery.) Oliver H. Lowry, B.S., Northwestern Ph.D., Washington University. 1974. University, 1932; Ph.D., University of Chicago, 1937; M.D., 1937. Professor Emeritas and Lecturer Helen B. Burch, B.S., Texas University for Women. 1926; M.S., Iowa State University, 1928; Ph.D., 1935. Professors Irving Boime, B.S., St. Louis College of Pharmacy, 1964; M.S., Purdue University, 1966; Ph.D., Washington University, 1970. (See Department of Obstetrics and Gynecology.) James A. Ferrendelli, A.B., University of Colorado, 1958; M.D., 1962. (See Departments of Neurology and Neurological Surgery and Ophthalmology.) F. Edmund Hunter, Jr., B.S., Mount Union College, 1938; Ph.D., University of Rochester, 1941. David B. McDougal, Jr., A.B., Princeton University, 1945; M.D., University of Chicago, 1947. Associate Professors David M. Geller, B.A., Amherst College, 1952; Ph.D., Harvard University, 1957. Eugene M. Johnson, Jr., B.S., University of Maryland. 1966; Ph.D., 1970. Assistant Professors Peter B. Corr, B.S.. Union University, 1971; Ph.D., Georgetown University, 1975. (See Department of Medicine.) Douglas F. Covey, B.S., Loyola College, 1967; M.A.. Johns Hopkins University, 1969; Ph.D., 1973. Jeanne E. Martin, B.A.. Winthrop College. 1969; Ph.D.. Duke University. 1974. Aubrey R. Morrison, MB., B.S., University of London, 1970. (See Department of Medicine.)

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ELECTIVES Department of Descriptions of the following courses may be found under the Division of Biology and Biomedical Sciences. Physiology and Bio 401. Vertebrate Physiology Bio 457. Somatosensory System Biophysics Bio 458. Biophysics of the Ear Bio 459. Vision The department offers instruction to medical and graduate students. A course in the second semester of the Bio 525. Fundamental Concepts in Cell Membrane Phy- first year of the medical curriculum is designed to provide siology and Biophysics students with a foundation for their further study of Bio 526. Selected Topics in the Physiology and Biophysics clinical and applied physiology. In addition, advanced of Cell Membranes courses open to medical and graduate students provide Bio 5451. Introductory Biophysical Chemistry for more detailed study of specific areas of physiology and biophysics. Bio 558. Formation and Maintenance of Synaptic The following research interests are represented in Connections the department at the present time: macromolecular Bio 559. Nerve, Muscle and Synapse structure as studied by x-ray crystallography and other Bio 562. Neural Control of Posture and Movement physical methods, the mechanism of action of polypeptide hormones, transport across cell membranes, epithe- lial transport, intracellular transport, secretion and uptake of macromolecules. and renal physiology, neuro- Note— The number preceding the course title indicates that the physiology. contractile activation of muscle, peripheral course carries credit in the Graduate School of Arts and circulation, respiration, and the application of computer Sciences. techniques to biological problems. The interests in neurophysiology concern principally membrane phenomena in nerve fibers, the physiology of synapse, and the function of receptors and sensory systems. Electron microscopy of nerve and muscle is used to relate structure and function in these tissues.

FIRST YKAR Rio 502. General Physiology 1 ectures. demonstrations, and laboratory experiments are utilized to provide a basis for understanding general physiological mechanisms and the functional organization of physiological systems that are of immediate or potential importance in medicine. Credit 8 units. (Staff) Bio 554. Neural Sciences An integrated course dealing with the anatomy and physiology of the nervous system at the cellular level. leading on to a consideration of sensory and motor systems. Credit 5 units.

RESEARCH Bio 590. Research The department offers a variety of research opportunities, particularly in the following areas: macromolecular structure as studied by x-ray crystallography; synthesis and biological activities of polypeptides; membrane transport; lysosomes and intracellular transport; neurophysiology, including nerve membrane, muscle, synaptic transmission, sensory systems (especially auditory and visual), electron microscopy of neural tissues, and biochemical regulation in neurons: circulation; respiration; renal physiology; and the application of computer sciences to physiological problems. (Staff) SJ L Faculty of the Department of Physiology and Biophysics

Edward Maliinckrodt, Jr., Professor and Head of Department Carlton C. Hunt, B.A.. Columbia University, 1939; M.D., Cornel] University, 1942.

Professors Emeriti Hollowell Davis, A.B., Harvard University. 1918; M.D., 1922; Sc.D. (hon.), Colby College, 1954; Sc.D. (hon.). Northwestern University, 1962; Sc.D. (hon.). Washington University, 1973. (See Department of Otolaryngology.) (Also Lecturer.) (Also Central Institute for the Deaf.) Arthur S. Gilson, Jr., B.S.. Dartmouth College, 1919; A.M., Harvard University, 1922; Ph.D.. 1924. Stanley Lang, Ph.B.. University of Chicago. 1948: B.S.. 1949; M.S., 1951; Ph.D., 1953.

Professors Jerome R. Cox, Jr. (Biomedical Engineering), S.B., Massachusetts Albert Roos, M.D., University of Thomas A. Woolsey, B.S.. University of Institute of Technology, 1947; S.M., Groningen. 1940. (See Department of Wisconsin. 1965; M.D., Johns Hopkins 1949; Sc.D., 1954. (See Biomedical Anesthesiology.) University. 1969. (See Department of Computer Laboratory.) (Also School of Carl M. Rovainen, B.S.. California Anatomy and Neurobiology.) Engineering and Applied Sciences.) Institute of Technology. 1962; Ph.D.. Nigel W. Daw, B.A., Trinity College. Harvard University, 1967. Assistant Professors Cambridge. 1956; M.A., 1961; Ph.D., Philip D. Stahl, B.S., West Liberty State Elsa Bello-Reuss, B.A., University of Johns Hopkins University, 1967. (See College. 1964; Ph.D., West Virginia Chile. 1957; M.D.. 1964. (See Department of Ophthalmology.) University, 1967. Department of Medicine.) Paul J. De Weer, B.S., University of Associate Professors Robert F. Rakowski, B.Ch.E.. Cornell Louvain. 1959; M.D.. 1963; M.S.. 1964; Leonard J. Banaszak, B.S., University University. 1964; M.Eng.. 1966; Ph.D.. Ph.D., University of Maryland, 1969. of Wisconsin, 1955: M.S., Loyola University of Rochester. 1972. John E. Heuser, B.A.. Harvard College. University. 1960; Ph.D.. 1961. (See Joshua R. Sanes, B.A., Yale College. 1964; M.D.. Harvard University. 1969. Department of Biological Chemistry.) 1970; Ph.D.. Harvard University, 1976. Garland R. Marshall, B.S.. California C. David Barry, B.Sc, Manchester Institute of Technology, 1962; Ph.D., University. 1962: Ph.D.. 1965. (Also Research Assistant Professors Rockefeller University, 1966. (See Computer Systems Laboratory.) T. M. Balasubramanian, UN. Department of Biological Chemistry.) Harold Burton, B.A.. University of University of Madras. 1962; B.S., F. Scott Mathews, B.S., University of Michigan. 1964; Ph.D.. University of University of Bombay. 1965; M.S., 1968; California. 1955; Ph.D.. University of Wisconsin. 1968. (See Department of Ph.D., St. Louis University. 1974. Minnesota. 1959. (See Department of Anatomy and Neurobiology.) Nobutaka Hirokawa, M.D., University Biological Chemistry.) Yasushi Fukami, M.D.. Kyoto of Tokyo, 1971; Ph.D.. University of Charles E. Molnar, B.S.E.E., Rutgers University. 1957; Ph.D.. 1961. Tokyo. 1978. University. 1956; M.S.E.E.. 1957; Duck O. Kim, B.S.. Seoul National Paul H. Schlesinger, B.S.. University of Sc.D.. Massachusetts Institute of University. 1968: M.S.. Rose Polytechnic Illinois. 1966: M.D.. University of Technology. 1966. (Also Computer Institute. 1969; D.Sc. Washington Chicago. 1970: Ph.D.. 1973. Systems Laboratory.) University. 1972. (Also Computer Robert S. Wilkinson, B.S.. Rice Alan L. Pearlman, A.B.. State Systems Laboratory.) University. 1968; M.A.. University of University of Iowa. 1958; M.D.. Robert F. Miller, M.D.. University of Texas. Austin. 1970; Ph.D.. 1974. Washington University. 1961. (See Utah. 1967. (See Department of Department of Neurology and Ophthalmology.) Instructor Neurological Surgery.) Lewis J. Thomas, Jr., B.S.. Haverford Shirley A. Sahrmann, B.S.P.T., Dale Purves, A.B., Yale University, College. 1953: M.D.. Washington Washington University. 1958; A.M., 1960: M.D., Harvard University, 1964. University. 1957. (See Department ot 1971; Ph.D.. 1973. (See Departments of Luis Reuss, B.A.. University of Chile. Anesthesiology and Biomedical Neurology and Neurological Surgery 1957; M.D.. 1964. Computer Laboratory.) and Program in Physical Therapy.)

X* T

Nutrition Research Laboratories, Dr. Robert Shank, Department of Dr. Ruth Brennan Irene Walter Johnson Institute of Rehabilitation, Dr. Michael Brooke Preventive Medicine Lipid Research Center, Dr. Gusta\> Schonfekl and Public Health FIRST YEAR Medicine in Modern Society This is planned as a series of 12 weekly lectures and The department offers instruction during the first discussions on topics selected to afford characterization and second years of the curriculum and provides other of medicine as a profession of singular importance to learning experiences in elective courses in the fourth year. modern society. There will be an attempt to identify some In the clinical clerkships of other departments, students of the challenges or problems which confront the profes- have experience in rehabilitation in the Irene Walter sion, as well as possible avenues leading to resolution and Johnson Institute of Rehabilitation. In the first semester new accomplishments. of the first year, the course Medicine in Modern Society Topics to be covered include description of the physi- provides background information, and students are cian's role, career choices within the profession, the orga- encouraged to participate in discussion of important and nization of medical care, regulation of physician and evolving issues of medical care. A course in statistical hospital services, the economics of medical care, assess- methods in medicine given in the second semester affords ment of risk-benefit in choice of diagnostic or treatment a basis for understanding quantitative assessment in biol- procedures, the interface between medicine and the law, ogy and medicine and prepares the student for critical and ethical considerations in the practice of medicine. evaluation of reports in the medical literature. Duringthe (Drs. Chaplin, Kahn, Benham, Vavra and Shank) second year in the course in pathophysiology, the depart- Introduction to Biostatistics ment contributes material concerning the epidemiology This introduction to the principles and methods of ill disease ami the variety ol factors m the person and biostatistics emphasizes the concepts of statistical meth- environment which contribute to the occurrence of dis- odology as being essential to proper application and ease, and provides approaches and methods for preven- interpretation of statistical methods. Elementary statisti- tion and control. Interested students may choose to par- cal techniques illustrating the use of statistical principles ticipate in more intensive study of certain of these subject in experimentation and clinical research are discussed. areas in the departmental elective offerings. Second semester. (Drs. McGue and Spitznagel) Opportunities for clinical and/or research experi- SECOND YEAR ence are provided by the following organizational units Pathophysiology within the department or cooperating with it: In lectures and demonstrations, there is description of Division of Applied Physiology, Dr. John Holloszy the patterns of occurrence and the distribution of selected Division of Biostatistics, Dr. D. C. Rao diseases in populations. Consideration is given to the Division of Health Care Research, Dr. Ix'e Benhani variety of characteristics of host, agent, and environment which determine the occurrence of specific disorders. Procedures which may be utilized to prevent or interrupt the course of disease and disability are described and evaluated. Patterns of provision of medical care and the social factors influencing health care needs are discussed. (Dr. Shank and Staff) Summer Traineeships in Physical Disability and Rehabilitation See Institute of Rehabilitation. (Dr. Brooke) FOURTH YEAR ELECTIVES Clerkship in Primary Care I This clerkship is designed to provide the student with firsthand experience with medical practice, in much the same manner that clerkships in other medical disciplines provide patient-care experience in supervised settings. The clerkship uses as its clinical setting the Medical Care Group of St. Louis (MCG), a teaching and research prepaid group practice. Students will join individual physicians in the Medical Care Group of St. Louis or in their private practices, and will work in their offices caring for patients under supervi- se sion. Preventive, social, and continuing aspects of medi- Inpatient Rehabilitation Care cal practice will be emphasized. It is hoped that this The Department of Rehabilitation Medicine of Jewish elective will give an overview of medical practice in inter- Hospital offers a 4- or 6-week elective course to senior nal medicine and in pediatrics, and will provide an oppor- medical students. The Department operates a 55-bed tunity for the student to see comprehensive medical care service for patients with physical disabilities, under the as it is practiced in St. Louis and as it exists in a group supervision of four full-time physicians. The case material practice model: the Medical Care Group. is varied and includes patients with spinal cord injuries, (Drs. Brett and Turner) strokes, Parkinson's disease, and arthritis. The department holds an Amputee Clinic twice a month and does all Family Practice Preceptorship the electromyographic examinations for Jewish Hospital. The Division of Health Care Research will monitor The medical students serve as externs. this elective. The student wishing such an experience should find the practitioner with whom he wishes to work They gain experience in the prescription of a rehabilita- and request that this physician send Dr. John J. Garrett tion program and follow their patients in physical ther- of the School of Medicine (I) a copy of his (the physi- apy, occupational therapy, speech therapy, or whatever cian's) curriculum vitae, (2) an outline of the program he other activity is applicable. They work with the ortho- will offer the student, and (3) a commitment to evaluate pedic, neurological, urological, and plastic surgery con- the student's performance. The student must provide (I) a sultants who serve this unit. The details of the program summary of his experience in the practice and a critical can be adapted to fit the particular interests of the indi- analysis of its usefulness in his medical education, and (2) vidual student. (Dr. Steinberg and Staff) at least six case summaries describing patients whose care HEALTH ADMINISTRATION AND he participated in and /or a report of a primary care PLANNING (HAP) research project in which he took part, i.e., a brief paper. As a specialty, health administration looks at medical (Dr. Garrett) care from an institutional and organizational perspective. Clinical Electives Rational health administration requires expert knowl- a) Exercise in Preventive Medicine and Medicine. edge in many areas including: law, finance, planning, and Exercise testing will include exercise electrocardi- organizational behavior. ography, exercise echocardiography, measurement The goals of this six-week elective are: of O2 uptake capacity, noninvasive cardiac output 1. To give the medical student an overview of the spe- measurement and radionuclide studies during exer- cialty of health administration including some contact cise. In addition, there will be opportunity to partic- with the supporting disciplines of hospital and health ipate in exercise training as a component of treat- law, hospital accounting and finance, organizational ment of patients with ischemic heart disease, hyper- behavior, health planning and health regulation. tension, diabetes and chronic uremia. (Drs. Holloszy, Ehsani and Hagberg) 2. To provide first hand contact with selected local institutions and their administrators. b) Physical disability and rehabilitation. (See Institute 3. To allow students to investigate particular subjects of Rehabilitation.) (Dr. Brooke) of interest to them. Physical Disability and Rehabilitation At the beginning of the elective the student will discuss The student will become familiar at first hand with the his/her particular background and interest with the HAP techniques for defining the extent of physical disability Faculty. A plan of study will then be formulated in the and with various approaches to its treatment. Emphasis context of the resources actually available through HAP. will be placed on methods used in physical, occupational, Throughout the period there will be weekly review ses- and speech therapy, and on the specialized contribution sions and at the end of the elective, the student will be to be made by rehabilitation social work, nursing, and expected to submit a report. vocational testing and counseling. Supervised visits may The purpose of the elective is not to make administra- be arranged to specially related outside facilities and tors out of physicians but rather it is anticipated at the end agencies (Visiting Nurses Association, Special School of the six weeks that the student will be able to communi- District, Shriners Hospital, Central Institute for the Deaf, cate with those persons who see medicine from an organi- manufacturers of prosthetics and orthotic devices). All zational viewpoint and will recall what to ask and what to the above will be accomplished in relation to selected expect from consultation with hospital and health patients assigned to the student for his supervision of their administrators. (Dr. Hepner and Staff) rehabilitation programs. In general, these will include inpatients on the Pediatrics, Medical Neurology, Neuro- SEMINAR ELECTIVES surgical, Orthopedic, and Plastic Surgery Services. Spe- Applied Biostatistical Techniques cial emphasis on any one or any combination of the above The seminar is intended for students who have com- services can be arranged to suit the interests of individual pleted a basic biostatistics course and who want to students. increase their understanding of contemporary statistical In addition to the programs available at the Rehabilita- techniques, particularly those commonly applied in clini- tion Institute, the student may choose to spend part of the cal research. Students will be expected to participate in elective at Jewish Hospital on the Rehabilitation Service. analysis and critique of studies appearing in the medical (Dr. Brooke) literature. The emphasis will be on the appropriateness of

X7 the statistical techniques and underlying rationale rather developments and applications of these techniques. than on mathematical details of the techniques. Both Topics to be covered include: path analysis, variance basic (e.g., t tests, chi-squared tests, correlation, regres- components, segregation analysis, linkage and genetic sion and more advanced multivariate techniques (e.g., counseling. (Dr. Rao and Staff) multiple regression, discriminant analysis, analysis of var- Health Care Research iance) will be covered during the seminar. Students will, with advice and consent of preceptor, (Mr. Miller and Staff) engage in studies pertinent to: 1) Medical Care in Group World Population Problems Practice (e.g., medical care utilization, reaction to illness, Five or six seminars will be conducted by invited guest screening, etc.); 2) Studies in Adult Ambulatory Care faculty who are nationally recognized experts in the (included are utilization, social and economic aspects of demographic, sociologic, economic, political, food- medical care, problems in medical care organization, or in supply, and ethical aspects of world population growth. community projects); 3) Studies in Pediatric Ambulatory 1 he lust 45 minutes of each seminar is given to a presenta- Care; 4) Studies in Obstetrics/Gynecology, and 5) any tion of key background material by the seminar leader; other topic in this area which is of mutual interest to the the final 45 minutes, to free discussion initiated by stu- student and his supervisor. dents. Suggested reading lists will be provided where (Dr. Kahn and Staff) appropriate. (Dr. Chaplin) Lipoprotein Metabolism Clinical Epidemiology and Health Care Policy Opportunities are available for interested students to Actual applications of clinical epidemiology in devel- participate in research projects dealing with normal and oping clinical protocols are reviewed and critiqued. disordered lipoprotein transport. Included are studies of Application areas to be reviewed are early detection of the effects of diabetes, uremia, diets and drugs on human breast and cervical cancer, and carcinogenic testing of lipoprotein levels, composition and structure; regulation food additives like saccharin. Background material on of apoprotein synthesis in cultured rat hepatocytes; and decision analysis, benefit-cost analysis, mathematical immunologic properties of apoproteins using monoclo- models and randomized clinical trials is developed as nal antibodies. (Dr. Schonfeld) needed (Dr. Gohogan) Topics in Medical Economics RESEARCH ELECTIVES This course is designed to expose students to economic issues in the medical sector. Students will pursue a Biochemistry of Kxcrcise selected research topic under an economist's supervision. Research deals with the acute and chronic responses to Emphasis will be placed on policy issues concerning the exercise. Areas of interest include biochemical adapta- effective allocation of medical expenditures. Examples of tions in muscle in response to endurance exercise and to topics which can be considered are: the economics of heavy resistance exercise; cardiac adaptations to in- excess capacity in surgery; the economics of prepaid creased work load; the serum triglyceride lowering effect group practice; the cost effectiveness of therapy for hyper- of exercise; the biochemical basis of muscle fatigue. tension, cost differences of therapies for a given medical (Drs. Ehsani, Hagberg, Holloszy) problem as a function of physicians' specialties; respon- Genetic Kpidemiology siveness of physician to alternative incentive schemes; After being introduced to current approaches in criteria to be used in determining the allocation of resour- Genetic Epidemiology, interested students will be super- ces among the medical subsectors. vised on research projects dealing with methodological (Dr. Benham)

Faculty of the Department of Preventive Medicine and Public Health Kountz Professor and Acting Professor Emeritus Medical Care Group.) (Also Pediatric Head of Department C. Howe Eller( Public Health), A.B., Nurse Practitioner Program.) Hugh Chaplin, Jr., A.B.. Princeton Stanford University. 1927; M.D., M. Kenton King, B.A.. University of University. 1943; M.D.. Columbia University of Colorado, 1930; Ph.D., Oklahoma, 1947; M.D., Vanderbilt University, 1947, (Sec IXnartmcnt Johns Hopkins University. 1934. University, 1951. (See Administration oi Medicine.) and Department of Medicine.) Professors Danforth Professor Michael H. Brooke (Rehabilitation), Gustav Schonfeld, A.B., Washington Robert K. Shank, A.B.. Westminster University. 1956; M.D., I960. (See College. 1935; M.D.. Washington MB., B.Ch.. Cambridge University. 1958. (See Department of Neurology Department of Medicine.) University, 1939, (See Department and Neurological Surgery and Irene John D. Vavra. B.A., University of of Medicine.) Walter Johnson Institute of Colorado, 1950; M.D., Washington Professor and Director of Rehabilitation.) University, 1954. (See Administration Applied Physiology Division Ijiwrence I. Kahn (Health Care and Department of Medicine.) John (). Holloszy, MO. Washington Research). A.B.. University of Alabama. Reimut Wette (Biostatistics), B.S.. University, 1957. (See IXpartment 1941; M.D.. Louisiana State University. University of Heidelberg. 1949; M.S.. of Medicine.) 1945. (See Department of Pediatrics and 1952; D.Sc. 1955. ss T

R. Dean Wochner, A.B., Arizona State Boas Gonen, B.Sc. Hebrew University, Kathleen S. Madsen (Biostatistics), University. 1956; M.D.. Washington 1966; M.D., 1973. (See Department B.Sc, University of Edinburgh, 1970; University. I960. (See Department of of Medicine.) Ph.D., University of Dundee. 1975. Medicine.) James M. Hagberg, B.S., Carthage Diana L. Reed (Social Work), A.B., College. 1972; M.S.. University of Washington University. 1968; Associate Professor and Director of Wisconsin, 1974; Ph.D., 1976. M.S.W., 1970. Division of Biostatistics J. Philip Miller (Biostatistics), A.B., Dabeeru C. Rao, B.S.. Indian Statistical Elizabeth A. Stoddard (Rehabilitation). Washington University. 1965. (See Institute. 1967; M.S., 1968; Ph.D.. 1971. B.S.. Montana State University. 1954; Biomedical Computer Laboratory.) M.D., Washington University. 1957. (See Departments of Psychiatry (See Department of Medicine.) and Genetics.) Wolfgang P. Patsch, M.D., University of Innsbruck, 1971. (Jewish Hospital) Associate Professor Emeritus John P. Rice (Biostatistics), B.A., In Sook Sunwoo (Rehabilitation). M. Frances Watson (Social and Cornel] University. 1969; M.A.. M.D., Woo Sok University, 1959. Environmental Studies). B.S., Northeast Washington University, 1972; Ph.D.. (Jewish Hospital) Missouri State Teachers College. 1932; 1975. (See Psychiatry.) M.S.W., Washington University, 1949. Robert S. Woodward (Health Care Research Instructor Research). B.A.. Haverford College. Associate Professors Kyung-soo 1 lalirn. B.S.. Yonsei 1965: Ph.D.. Washington University, Lee Benham (Health Care Research). University, 1969; M.S., North Carolina 1972. (See Health Administration and B.A., Knox College, 1962; Ph.D., Central University, 1975; Ph.D.. Planning Program.) Stanford University, 1970. (Also Faculty Duquesne University. 1979. of Arts and Sciences.) Instructors Barbara A. Pfleger, B.S.. St. Louis AH A. Ehsani, M.D., Tehran University, Susy Alias (Rehabilitation). B.Sc. Universitv. 1957. 1965. (See Department of Medicine and University of Kerala. 1964; M.D.. Calicut Medical College. 1969. Irene Walter Johnson Institute of Research Assistant Rehabilitation.) (Jewish Hospital.) May W-S. Chen, B.S.. Baker University. John K. Cohagan (Health Care- Bernard Feigenbaum (Health Care 1963. Research). B.A., LaSalle College. 1964; Research). B.A.. University of Ratna V. Dargar, B.Sc. University of M.A...Temple University, 1968; Ph.D., California. Los Angeles. 1974; M.A., Bombay. 1960; M.Sc. (in Biochemistry). Massachusetts Institute of Technology. 1976. (See Health Administration and 1962; M.Sc. (in Organic Chemistry). 1973. (Also Department of Engineering Planning Program.) 1964. and Applied Sciences.) A. Donna King (Social Work), B.A.. Martha C. Monroe, B.S., Iowa State Mary L. Parker, B.S.. Florida State Western Maryland College, I960; University, 1975. University. 1946: M.S., 1949; M.D., M.S.W., Washington University. 1966. Washington University. 1953. (See (See Medical Care Group.) Department of Medicine.) (University Matthew K. McGue (Biostatistics), Lecturer Health Service.) B.A.. University of California. Berkeley. Richard A. Surter(Industrial Medicine Edward L. Spitznagel, Jr. (Biostatistics). 1975; Ph.D., University of Minnesota. and Rehabilitation), A.B.. Washington B.S., Xavier University, 1962; M.S.. 1981. University. 1931; M.D., 1935. University of Chicago. 1963: Ph.D.. 1965. (Also Faculty of Arts and Sciences.) Associate Professor (Clinical) Franz U. Steinberg, M.D., University of Berne. 1938. (See Departments of Medicine and Surgery.) (Jewish Hospital.) Assistant Professors Emeriti Edward J. Berger, M.D.. Washington University. 1937. (Medical Director. Labor Health Institute.) Barbara B. Hixon (Biostatistics). B.S.. University of Illinois, 1941. Assistant Professors Ruth E. Brennan (Nutrition). B.S.. University of Tennessee, 1943; M.S.. Simmons College. 1945; Sc.D., University of Pittsburgh. 1966. Andrew P. Goldberg, M.D., State University of New York. 1969. (See Department of Medicine.) 1 X') 7

the director of the inpatient service. This rotation is par- Department of ticularly desirable for students going into family practice, general internal medicine, general pediatrics, or other nonpsychiatry specialties. The rotation provides an excel- Psychiatry lent opportunity to learn firsthand about psychiatric diagnosis, psychopharmacology, community resources, Instruction in psychiatry is given in the last three familial interventions, and further insights into the cur- years of the medical course. Emphasis is on teaching rent literature. (Dr. Helzer) psychiatry as a medical discipline, including the biologi- Clinical Psychiatry in a Community cal, social, and psychological mechanisms and manifesta- Mental Health Center tions of psychiatric illness, as well as psychological reac- I Ins elective course provides students with opportuni- tions to other illnesses. Recognition of current limitations ties to become key medical members of psychiatric treat- of knowledge combined with an appreciation of what is ment teams dealing with evaluation of patients in an known leads to a spirit of constructive skepticism. This emergency room, selective admissions of certain cases, attitude permits the student to study psychiatry in depth diagnosis and management of particular patients. Super- and broadly without preconceived theories. vision is provided by the full-time supervising psychiatrist SECOND YEAR in charge of wards to which the student may be assigned. The student participates in teaching sessions arranged for Introduction to Clinical Psychiatry first-year psychiatric residents in training at the Malcolm l-.mphasis is upon (a) effective interviewing in prepara- Bliss Mental Health Center. (Dr. M. Herjanic) tion for medical history taking, (b) evaluation of behavioral and emotional factors in patients with various kinds Child Psychiatry, Children's Hospital and the of illnesses, (c) the diagnosis and natural history of the Washington University Child Guidance Clinic major psychiatric disorders, (d) critical evaluation of con- This clerkship in child psychiatry gives students an ceptual and methodologic problems in psychiatry and appreciation of the intricacies of diagnosis and treatment psychology. Lectures, demonstration interviews, discus- of emotionally disturbed children. The clerkship involves sions. (Dr. Cloninger and Staff) working up a small number of preadolescent, as well as adolescent children under the supervision of senior staff THIRD YEAR members. Didactic teaching is available, as well as indi- Psychiatry Clerkship vidual supervision of patients. Students gain an apprecia- Students in groups of about 15 spend six weeks on the tion of both drug treatment and the limitations of drug inpatient services of Barnes, Jewish and Bliss Hospitals. treatment. They are exposed to the roles of community (Dr. Croughan and Staff) agencies such as settlement houses, juvenile courts, and FOURTH YEAR ELECTIVES various private agencies with which a child psychiatrist Outpatient Psychiatry must work. Students also gain appreciation of the roles of This is a flexible clerkship tailored to the student's nurse, social worker, teacher, and occupational therapist interests. Adult psychiatric patients in the Washington in collaboration with individuals of these disciplines. University Psychiatric Clinic present a variety of psycho- (Dr. T. Earls) logical and interpersonal problems similar to those Neurochemistry encountered in the office practice of a psychiatrist, an This course is given jointly by the Departments of internist, or a family physician. Students have an oppor- Psychiatry and Pharmacology. Topics covered include tunity to learn a variety of treatment techniques under carbohydrates; energy metabolism, including changes supen ision. found in different functional states; amino-acid metabo- Students also manage patients in a community mental lism and its relation to protein and transmitter synthesis; health eentei located in an innei cit\ area. 1 here, students special proteins and protein metabolism; cerebral lipids, see how psychiatry works with social agencies, schools, membranes, and normal and disordered lipid metabo- and other institutions utilizing paramedical personnel in lism; transmitters and modulators; learning; growth, the detection and treatment of mental illness. development, and trophic functions; cerebral blood flow, (Drs. Smith, Taylor) blood brain barrier. (Drs. McDougal, B. Moore) Clinical Psychiatry in Barnes Hospital Selected Topics in Research This is a senior course providing the student with an Students may elect to work full time in psychiatric opportunity to learn clinical psychiatry by functioning as research at any time during their elective year. Twelve an extern on a six-week rotation. The student participates weeks is the minimum time allowed; no maximum time is in a rolesimilai to that of a first-year resident and attends specified. The arrangements are made on an individual all rounds and conferences for first-year psychiatry resi- basis with the appropriate investigators. dents. The student takes night call approximately every (Drs. Cicero, Guze, Hartman, Helzer, fifth or sixth night. Supervision is by the chief resident and B. Herjanic, Murphy, Olney, Reich, and Staff) M 1 Faculty of the Department of Psychiatry

Spencer T. Olirt Professor and Marijan Herjanic, M.D.. Zagreb Research Professor Head of Department University, 1956. (Malcolm Mitchell Taibleson (Mathematics), S.M., Samuel B. Guze, M.D., Washington Bliss Hospital) University of Chicago, 1960; Ph.D., University, 1945. (See Administration Blake W. Moore (Biochemistry), B.S.. 1962. (Also Faculty of Arts and Department of Medicine.) University of Akron, 1948; Ph.D., and Sciences.) Northwestern University, 1952. (See Professors Emeriti (Clinical) Wallace Renard Professor Department of Biological Chemistry.) Eli Robins, A.B., Rice University, 1940; Margaret C. L. Gildea, B.S., University M.D.. Harvard University, 1943. George E. Murphy, B.S., Oregon State of Chicago, 1923; M.D.. Yale College. 1949; M.D., Washington University, 1936. Professor Emeritus University, 1952. Sydney B. Maughs, A.B.. Westminster Saul Rosenzweig (Medical Psychology). John W. Olney, B.A., Iowa University. College, 1931; M.D.. Washington A.B., Harvard University, 1929; M.A., 1956; M.D., 1963. (See Department University, 1935. 1930; Ph.D., 1932. (Also Psychology.) of Pathology.) Professors (Clinical) Professors Dabeeru C. Rao (Biostatistics), B.S., Richard W. Hudgens, B.A.. Princeton Indian Statistical Institute. 1967; M.S.. University, 1952; M.D., Washington Theodore J. Cicero (Neuro- 1968; Ph.D.. 1971. (See Departments of University. 1956. pharmacology), B.S., Villanova Genetics and Preventive Medicine and University, 1964; M.S., Purdue Alex H. Kaplan, B.S., College of City of Public Health.) University, 1966; Ph.D., 1968. (See New York. 1932; M.D., St. Louis Department of Anatomy and Theodore Reich, B.S., McGill University. 1936. Neurobiology.) University, 1959; M.D., 1963. (See Frank O. Shobe, A.B., Washington Department of Genetics.) C. Robert Cloninger, B.A., University of University, 1938; M.D., 1942. Texas, 1966; M.D., Washington Lee N. Robins (Sociology), B.A.. Associate Professors University, 1970. (See Department Radcliffe College. 1942; M.A., 1943; Jack L. Croughan, B.A., University of of Genetics.) Ph.D., 1951. (Also Faculty of Arts and Kansas, 1964; M.D., Kansas University. Irving I. Gottesman (Psychiatric Sciences.) 1968. Genetics), B.S., Illinois Institute of William R. Sherman (Biochemistry), John E. Helzer, M.D., University of Technology, 1953; Ph.D., University of A.B., Columbia University, 1951; Ph.D., Utah, 1967. Minnesota, I960. (See Department University of Illinois, 1955. (See Brian K. Suarez (Genetics), B.A., San of Genetics.) Department of Biological Chemistry.) Fernando Valley State College, 1967; Boyd K. Hart man, A.B., University of Kathleen Smith, B.S., University of M.A., University of California, Los Kansas, 1962; M.D., 1966. (See Arkansas, 1944; M.D., Washington Angeles, 1972; Ph.D., 1974. (See Department of Anatomy University, 1949. (Malcolm Department of Genetics.) and Neurobiology.) Bliss Hospital) Richard D. Wetzel (Medical Psychology), B.A.. Concordia College. 1959; B.D., Concordia Seminary, 1963; Ph.D., St. Louis University, 1974. Associate Professors (Clinical) John M. Anderson, B.S., Colorado State University, 1938; M.D., Meharry Medical College, 1958. (Malcolm Bliss Hospital) John T. Biggs, Jr., A.B.. Drury College, 1963; M.S., University of Tennessee, 1965; M.D., 1968. Robert B. Deitchman, B.A., University of Virginia, 1949; M.D., 1953. Edward H. Kowert, A.B.. Washington University, 1940; M.D., 1943. (Malcolm Bliss Hospital) Wanda M. Lamb, B.S., University of Missouri, 1946; M.D., Washington University, 1948. Patricia L. O'Neal, A.B., Washington University, 1944; M.D., 1948. Paul M. Packman, A.B., Washington University, 1959; M.D., 1963. Marcel T. Saghir, B.Sc., American University of Beirut, 1959; M.D., 1963.

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Karl R. Schultz, A.B., Southeast John P. Rice (Mathematics), B.A., Missouri State College, 1952; B.S.Med., Cornell University, 1969; M.A., University of Missouri, 1953; M.D., Washington University. 1972; Ph.D.. Washington University, 1955. (See 1975. (See Preventive Medicine and Department of Neurology and Public Health.) Neurological Surgery.) Sandra P. Schoenberg (Sociology). Harold I). Wolfl", A.B., Washington A.B., Sarah [.awrence College. 1954; University, 1952; B.S., University of M.P.A., University of Pennsylvania. Missouri, 1953; M.D., State University 1969; Ph.D., Bryn Mawr College, 1974. of Iowa, 1955. Burton Singerman, B.A., Case Western Reserve University, 1969; M.D., Harvard University, 1973; M.P.H., Assistant Professors Johns Hopkins, 1975. Bernardo G. Aleksander, Ml).. Roger K. Stoltzman, B.A.. Westmar University of Buenos Aires, 1959. College, 1972; M.D., University of (Malcolm Uliss Hospital) Nebraska. 1976. Michael I). Bieri, B.A., University of John R. Taylor, B.S.. Loyola University, Kansas, 1968; M.I)., Washington 1970; M.D., 1974. University, 1972. (Malcolm Michele Van Eerdewegh, M.D., Free Bliss Hospital) University of Brussels. 1970. Gregory Carey (Medical Psychology), Robert H. Vanderpearl, A.B.. B.A., Duquesne University, 1971; M.A., Washington University, 1950; M.D., New School for Social Research, 1973; 1954. (Malcolm Bliss Hospital) Ph.D., University of Minnesota, 1978. Shozo Yokoyama (Genetics), B.S., Mary I.. Carlson (Neuropsychology), Miya/aki University. 1968; M.S.. U.S., University of Wisconsin. 1961; Kyushu University, 1971; Ph.D.. M.A., Northwestern University, 1964; University of Washington. 1977. (Sec Lincoln B. Calvin, B.Ed., Illinois State Ph.D., lulanc University, 1967. Department of Genetics.) University, 1942; M.D., Meharry Robert M. Carney (Medical Research Assistant Professors Medical College. 1951. (Malcolm Psychology). B.A., University of Paul P. Hipps( Biochemistry), B.S.. Bliss Hospital) Missouri. St. Louis, 1969; M.S., Eastern lakeland College. 1966; Ph.D., North Sei Y. Choi, B.S., Woo Sok University, Kentucky University. 1972; Ph.D.. Dakota State University, 1971. 1951; M.D., 1963. (Malcolm Washington University, 1978. William H. Holland (Electronics), A.B., Bliss Hospital) Raymond S. Dean (Medical Washington University. 1950. (See William W. Clendenin, M.D., University Psychology), B.A., State University of Department of Biological Chemistry.) of Tennessee. 1963. New York. 1973; M.S.. 1974; Ph.D.. Madelon T. Price (Neurobiology), A.B.. Bun Tee Co, Jr., B.S., University of Arizona State University, 1978. Washington Universitv. 1953; Santo Tomas, 1963; M.D., 1967. Plaridel C. Deza, M.D.. University of Ph.D., 1973. (Malcolm Bliss Hospital) Santo lomas. 1956. (Malcolm Elizabeth M. Smith (Social Work). Juan C. Corvalan, M.D.. Argentina Hhss Hospital) B.A., University of Nebraska, I960; National University, 1965. Terry A. I ■idler. B.S.. University of M.S.W.. 1962; Ph.D.. Washington Mary E. Cox, A.B., Washington Notre Damedu Lac, 1970; M.D.. University, 1978. University, 1941; M.D., 1944. Washington University. 1974. Assistant Professors Emeriti (Clinical) Mary Davis, B.A., Ohio State Julian C. Hall (Social Work). B.S.. Robert M. Bell, M.D., St. Louis University. 1947; M.D., Washington Umvcrsitv ol 1 ouisville. 1949; M S . University. 1928. University, 1952. 1951; D.S.W.. Washington University. Hyman H. Fingert, B.A., State George H. Dowell, Jr., B.A.. Amherst 1968. (Malcolm Bliss Hospital) University of Iowa. 1931; M.D.. 1934. College, I960; M.D.. Washington Barry A. Hong (Medical Psychology), Reese H. Potter, A.B.. University of University, 1969. B.A.. Concordia Senior College, 1969; Kansas. 1931; B.S., University of Fred W. Gaskin, B.S.. University of M.Div., Concordia Seminary, 1972; Missouri. 1933; M.D.. Washington Minnesota. 1966; M.D., 1968. Ph.D.. St. Louis University. 1978. University. 1935. Wilbur H. Gearhart, B.S., Butler John W. Knesevich, A.B.. Indiana Assistant Professors (Clinical) University. 1949; M.D., Hahnemann University, 1971; M.D.. McCiill John F. Bergmann, A.B.. Washington Medical College, 1950. University. 1974. University. 1950; M.D., 1954. James N. Haddock, A.B.. University of Collins K. Lewis, B.A.. Rutgers Robert D. Brookes, A.B.. DePauw Missouri. 1940; M.A., 1942; M.D.. University, 1967; M.D.. Harvard University. 1934; M.D.. Washington Washington University, 1943. University, 1971; M.P.H., 1975. University. 1938. Robert S. Hicks, A.B.. Hendrix College. Lynn J. Mel aughlin (Medical Jane E. Brownstone (Medical 1951; M.D.. University of Psychology), B.A., Cion/aga University. Psychology). A.B.. Washington Arkansas, 1958. 1965; M.S'. St. Louis University. 1968; University.' 1961; A.M.. 1964; Ph.D.. R. Eugene Holemon, A.B.. Washington Ph.D.. 1972. (Malcolm Bliss Hospital) 1968. (Malcolm Bliss Hospital) University. 1954; M.D.. 1958. n I I

Natarajan Lakshminarayanan, M.B.. Anna K. Bradley (Social Work). B.J., Michael N. Stake (Medical Psychology), University of Madras. 1960; M.S., 1960; University of Missouri, 1956; M.S.W., B.A., Long Beach State University, M.D., 1967. (Malcolm Bliss Hospital) Washington University, 1958. (Malcolm 1970; M.A.. Arizona State University, ] Jay L. Liss, A.B., Washington Bliss Hospital) 1974; Ph.D., 1976. (Malcolm Bliss University, 1962; M.D., 1966. Morris D. Fishbein (Medical Hospital) Joe K. McKinney, B.A., Westminster Psychology), B.A., Tulane University, Deborah E. Wald (Social Work), B.A., College, 1954; M.D., Washington 1976; M.A., University of Missouri, University of Hawaii, 1975; M.S.W.. University, 1958. 1979; Ph.D., 1981. (Malcolm Bliss Washington University, 1975. ] Hospital) (Jewish Hospital) Jay Meyer, A.B., Washington Tamara Frishberg, M.D.. Vinnit/a University, 1956; M.D., St. Louis Research Instructor University, I960. Medical School, 1961. (Malcolm Bliss Hospital) Juanita L. Carl (Biochemistry). B.S.. Mary A. Montgomery, A.B.. Vassar Drury College, 1959; A.M., Washington ] College, 1967; M.D., Northwestern Shrikrishna Kulkami, M.D., J.N. University, 1962. University, 1973. Medical College, 1973. (Malcolm Bliss Hospital) Bharat R. S. Nakra, F.Sc, Punjab Instructors (Clinical) University, 1961; M.B.B.S., 1966. Judith A. McGee (Medical Psychology), Lachman K. Abichandani, B.S., Vikram ] (Malcolm Bliss Hospital) B.A., Long Island University, 1969; University, 1970; M.D., Far Eastern Earni Pal, M.B.B.S., Andhra M.S., St. Louis University, 1975; Ph.D., University, 1974. (Malcolm Bliss 1979. (Malcolm Bliss Hospital) University, 1965. (Malcolm Bliss Hospital) Hospital) John F. Mueller (Social Work), B.S., Felipe Crimi, M.D., National University Washington University, 1947; M.S.W., ] Thomas F. Richardson, B.A., Millikin of Cordoba, 1946. (Malcolm University, 1959; M.D., Washington 1952. (Malcolm Bliss Hospital) Bliss Hospital) University, 1963. Muniyapla T. Rajappa, M.B.B.S.. Alejandro M. Datuin, A.A., University William M. Riedesel II, A.B., University Mysore Medical College. 1973. of Santo Tomas, 1951; M.D., 1965. 1 of Rochester. 1968; M.D., Cornell (Malcolm Bliss Hospital) (Malcolm Bliss Hospital) University, 1973. Samuel H. Rosen, B.A., Emory University, 1971; M.D., University of Alabama. 1974. (Malcolm Bliss ] Hospital) Reed E. Simpson, B.A.. Wabash College, 1972; M.D., Washington University, 1976. (Malcolm Bliss ] Hospital) James B. Smith, A.B., University of Missouri. 1963; M.D., 1967. Alberto Soto, B.S., Instituto de ] Santiago, 1951; M.D., Havana University, 1960. Cengiz M. Sumer, M.D., Istanbul University, 1951. (Malcolm ] Bliss Hospital) John Sweet, B.A.. University of Michigan. 1964; M.D., University of Missouri, 1968. (Malcolm ] Bliss Hospital) Leonard J. Wiedershine, A.B., Washington University, 1943; M.D.. 1946. Edwin D. Wolfgram, B.A., State ] University of Iowa. 1954; M.D., 1959.

Instructors ] Ahmad Ardekani. M.D.. Pahlavi University. 1974. (Malcolm Bliss Hospital) Kathryn G. Bennett (Social Work). ] B.A.. University of Kansas, 1938; M.S.W.. Smith College. 1940. (Jewish Hospital)

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Pacita C. l)y, A. A., University of the Dean L. Rosen (Medical Psychology), Theodis M. Wheatt, B.S., Tuskegee East, 1959; MIX. lar Eastern B.S., University of Iowa, 1968; Psy. D., Institute, 1971; M.D., Washington University, 1967. (Malcolm Bliss University of Illinois, 1977. (Malcolm University, 1975. (Malcolm Hospital) Bliss Hospital) Bliss Hospital) Lecturers Randy I.. Hammer (Medical Kenneth L. Russ (Medical Psychology). Psychology), B.A., Washington A.B., University of Rochester, 1965; Michael Merbaum (Medical University. 1970; I'h.D., 1975. M.S., University of Pittsburgh, 1969; Psychology), B.A., Drake University, (Jewish Hospital) Ph.D., 1970. (Jewish Hospital) 1956; M.A., University of Missouri, 1957; Ph.D., University of North Ahid Hussion, Ml), Osmania Jo-EUyn M. Ryall, B.A., Rutgers Carolina, 1961. (Also Psychology) University. 1974. (Malcolm Bliss University, 1971; M.D.. Washington Robert C. Kolodny (Human Sexuality), Hospital) University. 1975. B.A., Columbia University, 1965; M.D., Rashml R. Nakra, M.B.B.S., Lady Washington University, 1969. (See Hardinge, 1970. Allahyar Samadaei, Ml). Pahlavi Department of Medicine.) University, 1973. (Malcolm Bliss Virginia Johnson-Masters (Human Richard W. Nysewander, U.S.. Cieorgia Hospital) Sexuality), D.Sc. (Hon.). University of Institute of technology, 1971; M.D., Louisville, 1978. Medical College of (ieorgia, 1975. Paul W. Sheffner, B.A.. Wabash College. 1970; M.D., Washington William H. Masters (Human Sexuality). Ronald A. Oliver ( Medical Psychology). University, 1974. B.S., Hamilton College, 1938; M.D., B.A., University of Rhode Island. 1968; Rochester University. 1943; Sc.D. M.A., Xavier University, 1970; Ph.D., Wayne A. Stillings, B.A.. Oberlin (Hon.), Hamilton College, 1973. (See Iowa State University, 1973. (Malcolm College. 1971; M.D., Washington Department of Obstetrics and Hliss Hospital) University, 1975. Gynecology.)

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WILLIAM GREENLEAF ELIOT DIVISION pital, its Child Psychiatry Clinic at 369 North Taylor OF CHILD PSYCHIATRY Avenue, and the Hawthorn Children's Psychiatric Hospi- The Division of Child Psychiatry offers a varied tal. Trainees are assigned to these various units, where teaching program for residents in psychiatry and fellows they participate in diagnostic evaluations and see patients in child psychiatry through the St. Louis Children's Hos- in treatment under supervision.

Director and Associate Professor Zila Welner (Child Psychiatry), M.D., Robert P. Wade (Psychiatric Social Felton J. Earls (Child Psychiatry), B.S., Hebrew University Hadassah Medical Work), B.A., Maryknoll College, I960; Howard University, 1963; M.D., 1967. School, 1961. (See Department M.S.W., St. Louis University. 1969. (See Department of Pediatrics.) of Pediatrics.) Lillian B. Weger (Psychiatric Social Julien Worland (Medical Psychology), Work), B.A., Barnard College, 1954; Blanche F. Ittleson Professor B.A., McGill University, 1966; Ph.D., M.S.W., Columbia University. 1956. E. James Anthony (Child Psychiatry) Washington University, 1973. Helen L. Zibit (Psychiatric Social B.S., University of London, 1938; Work), B.A., Drake University. 1950; M.R.C.S., L.R.C.P., 1941; M.B., B.S., Assistant Professors (Clinical) M.A., Indiana University, 1955. 1942; D.P.M., 1947; M.D., 1949. Haruo Kusama (Child Psychiatry), A.B., Washington University, I960; Associate Professor M.D., 1965. Instructors (Clinical) Barbara M. Herjanic (Child Psychiatry), Paul H. Painter (Child Psychiatry), Alicia D. Gonzalez (Child Psychiatry). B.A., Northwestern University, 1943; M.D., St. Louis University, 1947. (See M.D., University of Buenos Aires, 1961. B.S.. Western Michigan College, 1946; Department of Pediatrics.) Anna E. Hartnett (Child Psychiatry), M.D., University of Michigan, 1950. Adolfo E. Rizzo (Child Psychiatry), B.S., Loyola University, 1956; M.D., (See Department of Pediatrics.) M.D., Buenos Aires University, 1955. University of Ottawa, 1960. Assistant Professor Emeritus Emel A. Sumer (Child Psychiatry), Julio Morales (Child Psychiatry), M.D. University of Trujillo, 1966. Loretta K. Cass Seleski (Medical M.D., University of Istanbul, 1957. Diane Kankin (Child Psychiatry), Psychology), B.A., Colorado College, Instructor Emerita 1934; M.A.. 1942; Ph.D., Ohio State B.A., University of Colorado, 1962; Louetta Berger (Psychiatric Social M.D., 1968. University, 1950. Work), B.S., University of Wichita, 1941; M.S.W, Washington University, 1946. Jagdish C. Suri (Child Psychiatry), Assistant Professors B.Sc, Lucknow University, 1954; Cynthia L. Janes (Medical Psychology), Instructors M.B.B.S., King George's Medical B.A., University of Oklahoma, 1965; Erna C. Jenkins (Psychiatric Social College, 1959; M.D., Lucknow Ph.D., 1970. Work), A.B., Fontbonne College, 1959; University, 1964. (Hawthorn Children's David G. Weeks (Medical Psychology). M.S.W, University of Missouri, 1961. Psychiatric Hospital) B.A., California State University at Gail A. Overbey (Medical Psychology), Eliza E. Wochnik (Child Psychiatry). Fullerton, 1975; M.A., University of B.S., Southeast Missouri State M.D.. Medical Academy of Warsaw. California at Los Angeles, 1976; University. 1973; Ph.D., University of 1962. (Hawthorn Children's Psychiatric Ph.D.. 1978. Texas at Austin, 1979. Hospital)

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mammography), third floor (neuroradiology, vascular Department of radiology, ultrasound, and genitourinary radiology), fourth floor (gastrointestinal and genitourinary radiology), and the fifth floor (pediatric radiology). Cardiac Radiology radiology and the Division of Nuclear Medicine are located on the ninth floor of the West Pavilion. The tenth The Department of Radiology is located primarily floor of the West Pavilion is dedicated entirely to out- in the 13-story Mallinckrodt Institute of Radiology, but patient services. The modern features of the Institute also occupies space in the West Pavilion of Barnes Hospi- include five CT scanners and two digital subtraction tal, Barnard Hospital, St. Louis Children's Hospital, and systems. the Washington University Clinic Building. The depart- The sixth floor of the Institute contains the Division ment provides diagnostic radiology, nuclear medicine, of Radiation Sciences, which also utilizes two medical and radiation oncology services to Barnes Hospital and cyclotrons in Barnard Hospital. Additional research facil- St. Louis Children's Hospital. ities are located on the seventh floor (nuclear medicine), Clinical facilities for the Division of Radiation ninth floor (diagnostic radiology), tenth floor (cancer Oncology are located on the ground floor of the Institute biology), sixth floor of Barnard Hospital (radiation and in Barnard Hospital. Therapy equipment consists of oncology), and the 4511 Forest Park building (cancer an advanced .15 MV linear accelerator, 20 MV linear biology). accelerator, 6 M V linear accelerator, 4MV linear acceler- Administrative, teaching, and support functions ator, and Cobalt 60 therapy. There are also facilities and occupy the eighth and eleventh floors. The twelfth floor is an ample stock of Cesium 137 sources for both interstitial occupied by sophisticated computer facilities that are and intracavitary therapy. utilized for clinical, research, and teaching applications. The first floor of the Institute houses administrative The undergraduate teaching program is designed to and business offices, film library, consulting viewing present both diagnostic and therapeutic radiology to stu- rooms, and the 135-seat Scarpellino Auditorium. dents as part of the clinical clerkship experience. Every Fifty-five examination rooms for diagnositc radiol- effort is made to provide an opportunity to correlate ogy are available in the Institute and the newly con- radiologic and clinical findings through interdepartmen- structed West Pavilion. Institute facilities arc located on tal conferences, consultations, and group discussions. the second floor (chest, musculoskeletal radiology, and SECOND YEAR Twenty-six hours of lecture are devoted to an introduction to radiology. The majority of the course is devoted to diagnostic radiology including computed tomography, ultrasound, and nuclear medicine. Radiation biology and radiation oncology are also introduced. ELECTIVES RESEARCH ELECTIVES Opportunity is available to carry out research in the laboratories under the guidance of the staff in the fields of diagnostic radiology, therapeutic radiology, radiation physics, nuclear medicine, and radiation and cancer biology. ONCOLOGY CLERKSHIP FOR FRESHMAN STUDENTS A ten-week summer clerkship program is available for freshman medical and dental students. The students participate in the clinical activities of the Division of Radia- tion Oncology and are exposed to the fundamental concepts of cancer biology and clinical radiation therapy in a series of lectures, seminars, and case presentation conferences. They have the opportunity to conduct some laboratory research or clinical investigation under the direction of the staff members of the sections of Clinical Radiation Oncology and Cancer Biology. (Dr. Simpson) CANCER BIOLOGY COURSE January-April: consult coursemaster for exact time and dates. Topics to be covered include: interaction of radiation with matter: radiation chemistry and effect on

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macromolecules; target theory and dose-survival curves; student on the rotation will spend two to three weeks on i cellular radiobiology with emphasis on nuclear effects, subspecialty sections within the department (abdomen, age-response and repair, the oxygen effect and dose frac- bone and joint, cardiac, chest, neuroradiology, nuclear tionation; radiation effects on cell renewal systems and on medicine, pediatric radiology, radiation oncology, and organs, radiation genetics and long-term effects; radia- Queeny Tower radiology) under the supervision of a i tion sensitization and interaction with other anticancer senior faculty member. The student will have a chance to agents. (Dr. Sapareto) observe special procedures as well as routine radiological examinations. Conferences intended to complement the FOURTH YEAR ELECTIVES subspecialty approach to radiology round out this six- Clerkship in Radiation Oncology week experience. (Dr. Aronberg) Six-week elective in which the student has the oppor- Additional six-week clerkships in diagnostic radiology tunity to see patients being evaluated and treated in Radi- are offered at Jewish Hospital(Dr. Hyman Senturia) and ation Oncology. Emphasis is on techniques of cancer St. Luke's Hospital (Dr. Mayes) diagnosis and localization, selection of therapy, indica- Clerkship in Clinical Nuclear Medicine tions for irradiation and techniques on treatment plan- A six-week elective in which the student will be exposed ning, simulation and irradiation of a variety of tumors. to the full range of techniques, including organ imaging There are several conferences in which the students partici- with radionuclides. nuclear hematology, in vitro tests, pate, including new case planning conferences, clinical and radionuclide therapy. The student will be responsible physics conference, protocol conference, and interdepart- for planning appropriate isotope studies in patients mental conferences with the Department of Pediatrics, referred to the department in conjunction with the staff. Obstetrics and Gynecology, Surgery and Pathology. Opportunity exists to learn instrumental techniques, in- (Drs. Marks or Perez) cluding new ones such as computer applications. Partici- Clerkship in Diagnostic Radiology pation in clinical and laboratory research projects may A six-week elective which emphasizes the role of radi- also be arranged if desirable. There are daily conferences ology in the solution of clinical diagnostic problems. Each and scan interpretation sessions. (Dr. B. Siegcl)

Faculty of the Department of Radiology

Elizabeth E. Mallinckrodt Professor Marcus E. Raichle (Radiation Sciences). Professor Emeriti (Clinical) and Head of Department and B.S., University of Washington. I960; Hyman R. Senturia, A.B.. Washington Director of the Mallinckrodt Institute M.D.. 1964. (See Department of University, 1929; M.D.. 1933. of Radiology Neurology and Neurological Surgery.) Ronald G. Evens, A.B.. Washington Stuart S. Sagel, B.A.. Temple University. 1961; M.D., 1964. University, 1961; M.D., 1965. Associate Professors Gary D. Shackelford, B.A.. Daniel R. Biello, B.A., Ohio Wesleyan Northwestern University. 1964; M.D.. University. 1969; M.D.. Case Western Professors Washington University. 1968. (See Reserve, 1973. Mokhtar Gado, MB., B.Ch., Cairo Department of Pediatrics.) John O. Eichling (Radiation Sciences). University, 1953: DM RE. I960. Barry A. Siegel, A.B.. Washington B.S., Northeastern Oklahoma State Louis A. Gilula, M.D., University of University, 1965; M.D., 1969. (See College. 1958; M.S., Oklahoma State Illinois, 1967. Department of Medicine.) University. 1959; Ph.D.. Washington University. 1970. Robert L. Grubb, Jr. (Radiation Michel M. Ter-Pogossian (Radiation Sciences), A.B.. University of North Sciences). B.A.. University of Paris. Rexford L. Hill (Computer Sciences). Carolina, 1961; M.D., 1965. (See 1943: M.S., Washington University, B.S.. University of Cincinnati. 1964: Department of Neurology and 1948: Ph.D.. 1950. (Also School of M.S.. 1966. (See Biomedical Computer Neurological Surgery.) Engineering and Applied Science.) Laboratory.) Fred J. Hodges III, B.A., University of Leonard J. Tolmach (Radiation R. Gilbert Jost, A.B., Harvard Wisconsin. 1944; M.D., 1946. Biology). B.S., University of Michigan. University. 1964; M.D.. Yale James E. Marks, A.B.. Knox College, 1943: Ph.D., University of Chicago. University. 1969. 1951. (See Department of Anatomy 1961; M.D. Washington Joseph K. T. Lee, B.Sc. Chinese and Neurobiology.) University, 1965. University of Hong Kong. 1968; M.D., William H. McAlister, B.S., Wayne Teresa J. Vietti (Radiation Oncology). Washington University. 1973. A.B.. Rice University. 1949: M.D.. State University. 1950: M.D., 1954. (See Robert G. Levitt, B.A., University of Department of Pediatrics.) Baylor University. 1953. (See Department of Pediatrics.) California. 1968; M.D., 1972. Bruce L. McClennan, B.S.. Union Michael J. Welch (Radiation Hsiu-san Lin (Cancer Biology). M.D.. College. 1963; M.D.. State University of Chemistry). B.A.. Cambridge Taiwan University, I960: Ph.D., New York. Upstate. 1967. University. 1961: M.A.. 1964: Ph.D.. University of Chicago. 1968. (See Carlos A. Perez, B.S.. University of University of London. 1965. (Also Department of Microbiology Antioquia. 1952; M.D.. I960. Faculty of Arts and Sciences.) and Immunology.)

W I'hilip K. I.udbrook, MIL US. Bahman Kniami, Ml)., lehran William G. Totty, B.A., David University ol Adelaide, 1963. (See University, 1968. Lipscomb College. 1969; M.D., Department ol Medicine.) Edward M. Geltman, B.S.. University of Tennessee, 1975. Robert ('. Mcknight, IIS. Florida Massachusetts Institute ol Iechnology. Michael W. Vannier, B.S., Colorado Slate University, 1957; Ml).. 1967; M.D., New York University, 1971. State University, 1971; B.S.M.E., Washington University, 1961. (See (See Department of Medicine.) University ol Kentucky. 1971; Department of Medicine.) Glenn P. Glasgow (Radiation Physics), M.D., 1976. (.. I eland Melson, B.A., Ottawa B.S., Western Kentucky State College, Gary E. VanZant (Cancer Biology), University. 1961; M.I).. Washington 1965; M.S., University of Kentucky, B.S., University of Nebraska, 1966; University, 1965. 1969; Ph.D., 1974. M.S., 1968; Ph.D., New York William A. Murphy, Jr., US, Fernando K. Gutierrez, M.D., University, 1973. University ol Pittsburgh. 1966; Ml)., University of Valladolid, 1974. Philip J. Weyman, B.A., Yale Pennsylvania State University. 1971. Donald V. lluebener (Dental Medicine), University, 1968; M.D., 1972. Miljenko V. Pilepich, Ml)., University D.D.S., Washington University, 1969. ol Zagreb, 1965. (See Department of Pediatrics.) (Also Assistant Professors (Clinical) School of Dental Medicine.) .luiiies A. I'urdy (Radiation Physics), Robert J. Baglan, B.S., University of U.S., I.iimar University, 1967; M.A., Bharath A. K. Kumar, M.B.B.S.. Kentucky, 1965; Ph.D., University of University ol rexas, 1969; Ph.D., 1971. Andhra University Medical California, 1970; M.D., Washington Bruce J. Walz, A.B., Washington College, 1969. University, 1976. University, 1962; M.D., 1966. Michael R. Kilbourn, B.S., University of John L. Bardsley, B.A., University of lodd II. Wasserman, A.B.. University ol Michigan. 1975; Ph.D., University of Illinois, 1961; M.D.. 1964. Illinois, 1979. Rochester. 1968; Ml).. University of Enrique Cubillo, M.D., University of Rochestei School ol Medicine and Karen D. McElvany, B.A., College of Madrid, 1962. Dentistry, 1972. Wooster, 1976; A.M., Washington James W. Debnam, Jr., B.A., University University, 1977; Ph.D., 1979. Associate Professor Emeriti (Clinical) of Louisville, 1958; M.D., 1962. lorn R. Miller, B.S.. California Institute A. Norman Arneson, U.S.. lexas Keith C. Fischer, A.B., Oberlin College, of Technology, 1966; M.S., Stanford Christian University, 1924; M.D., 1967; M.D., Johns Hopkins University, 1969; Ph.D., 1971; M.D., Washington University, 1928. University, 1971. University of Missouri, 1976. (See Department ol Obstetrics Guillermo C. Geisse, B.A., University of and (iynccology.) Alexander N. NakefT(Cancer Biology), Chile, 1957; M.D., 1965. B.S., University of Toronto. 1962; M.S.. Associate Professors (Clinical) 1965; Ph.D., University of Albert E. Hesker, A.B.. University of Charles I.. Abramson, A.B., New York Rochester, 1969. Missouri, 1961; M.D., 1964. University. 1957; M.D.. University of Fransiska Lee, A.B., Washington Gilbert H. Nussbaum, B.S., City Basel. 1963. University, 1962; M.D., 1966. College of New York. I960; M.A., Mark I). Eagleton. Jr., A.B.. Amherst Harvard University. 1962; Ph.D., 1967. MacDonald B. Logie, B.S., College. 1947; Ml).. Washington Northwestern University, 1965; University, 1950. < .union L Phillips, B.A.. University of M.D.. 1967. Oklahoma. 1966; M.D.. 1971. (See Sunnier Holt/, MB., St. Louis Department of Medicine.) Ben R. Mayes, Jr., B.A., Vanderbilt University, I94S University, 1962; M.D., Washington Noah Susman, A.B.. Washington D. Venkato Rao, M.D., Osmania University. 1966. Medical College, 1973. University, 1948; M.D.. 1952. Allan H. McCown, B.S., University of (Jewish Hospital) Stephen A. Sapareto (Cancer Biology). Idaho, 1962; M.D., Washington B.S.. University of Massachusetts. 1971; University, 1964. Assistant Professors M.S., Colorado State University. 1973; Christopher J. Moran, B.S., University Dixie J. Vronberg, B.A.. Hendrix Ph.D.. 1978. College. 1967; Ml)., Washington of Notre Dame, 1970; M.D., St. Louis Marilyn J. Siegel, A.B., Washington I niversity, 1971. University. 1974. University, 1965; M.D., State University Dennis M. Balfe. B.S., University of Arthur A. Porporis, A.B., Washington of New York, 1969. (See Department University, 1946; M.D., 1948. Santa Clara, 1968; M.D.. Medical of Pediatrics.) College of Wisconsin. 1975. Wayne A. Simril, A.B.. Culver-Stockton Joseph R. Simpson, A.B., Cornell John M. Bedwinek, B.A.. Oberlin College, 1941; M.D.. Washington University. 1963; Ph.D.. University of University, 1944. College. 1967; Ml).. Columbia Chicago. 1967; M.D., Harvard Chandrakant C. Tailor, M.B.B.S., I diversity College ol Physicians and University, 1973. Surgeons. 1971. Maharaja Sayajirao University of Emily L. Smith, A.B.. Washington Baroda, 1972. Dimming Ben Chen, HS„ Fu Jen University. 1964; M.D.. 1968. University. 1969; M.S., State University of New York. 1972; Ph.D.. Vanderbilt Alan J. Tiefenbrunn, A.B.. Washington Instructors University. 1970; M.D., 1974. (See I imersity, 1977. Frederick G. Abrath (Radiation Department of Medicine.) Judy M. Destouet, B.S . I niversity ol Physics), B.S.. University of Wisconsin. Southwestern Louisiana. 1969; Ml).. Patrick R. M. Thomas, B.S.. London 1967; Ph.D., North Texas State Baylor College ol Medicine. 1975. University. I%5; M.B.. 1968. University, 1974.

OS I

Gerald Edelstein, B.S., Pennsylvania State University, 1964; D.O., Philadelphia College of Osteopathic Medicine, 1968. Seymour Fox (Computer Sciences), I B. Comm.. McGill University, 1971; M.S., University of Oregon, 1972; Ph.D., University of Oklahoma, 1977. Harvey S. Glazer, B.A., Washington I University, 1971; M.D., 1976. Jay P. Heiken, B.A., Williams College, 1974; M.D., Columbia University, 1978. Pamela A. Kopen, B.S.. Lafayette College, 1974; M.D., Pennsylvania State University, 1978. Barbara Monsees, B.A., Brandeis University, 1971; M.D., Washington University, 1975. Jashbhai I. Patel, MB., B.S., Seth G. S. Medical College, 1974. William J. Powers (Radiation Sciences), A.B., Dartmouth College, 1971; M.D., Cornell University, 1975. (See Department of Neurology and Neurological Surgery.) Ralph L. Smathers, Jr., B.S., University of Florida, 1974; M.D., University of Chicago, 1978. Jonathan S. Stein, MB., B.Ch., Witwatersrand University, 1975. Donald E. Wadsworth, B.S., Portland State University, 1961; M.D., University Daniel J. Leary, Jr., B.S.. St. Louis Duan Liang, National Wu-Han of Oregon. 1964. University, 1962; M.D., Washington University. Franz J. Wippold II, B.A., Westminster University, 1966. Peter A. Parrino, B.S.E.E., Worcester College, 1973; M.D., St. Louis Gary H. Omell, M.D., University of Polytechnic Institute, 1962; M.S.E., University, 1977. Tennessee, 1967. Pennsylvania State College. 1970. Research Instructor Gary A. Ratkin, B.A., Rice University, Research Assistants Kondapuram S. Sampathkumaran, 1963; M.D.. Washington University, Dean M. Coulter, B.S., Weber State B.S., Bangalore University, 1970; M.S.. 1967. (See Department of Medicine.) College, 1967; M.S., Utah State 1972; M.S., McMaster University, 1976. Naris Rujanavech, M.D., Faculty of University, 1975. Instructors (Clinical) Medicine, Siriraj Hospital, 1972. David C. Ficke, B.S.E.E., Southern Stephen F. Albert, A.B., Washington Robert F. Scheible, A.B., Johns Illinois University, 1974. University, 1964; M.D., St. Louis Hopkins University, 1968; M.D., Gary R. Hoffman, B.A., University of University, 1968. Washington University, 1972. Missouri, 1976. Gerald L. Shaikun, B.S., University of Edward Cohen, A.B., Washington Lecturer University, 1961; M.D., University of Kentucky, 1960; M.D., University of Missouri, 1969. Chicago. 1964. Armand Diaz (Radiologic Technology), R.N., R.T., Havana University School Gene W. Spector, B.A., Amherst Gene L. Davis, Jr., B.A.. University of of Medicine. 1948. (See Program in College, 1954; M.D., Yale Virginia. 1968; M.D., 1972. Radiologic Technology.) University. 1959. Beauvoir H. Edmond, B.S., Lycee Consultant Petion, 1949; M.D., University of Frederick R. Zivnuska, B.S., St. Haiti, 1955. Procopius College, 1961; M.S., Mildred Trotter (Anatomy), A.B., Mount Holyoke College, 1920; Sc.M., Albert M. Hammerman, A.B., Marquette University, 1964; M.D., University of Wisconsin. 1970. Washington University, 1921; Ph.D., Washington University, 1973; 1924; Sc.D., (hon.). Western College. M.D., 1976. Research Associates 1956; Sc.D., (hon.). Mount Holyoke Lawrence M. Kotner, Jr., B.A., Karen L. Beetham, B.A., St. Olaf College, 1960; Sc.D., (hon.), Washington Washington University, 1965; College, 1968; M.S., University of Iowa, University, 1980. (See Department of M.D., 1968. 1971; Ph.D.. 1974. Anatomy and Neurobiology.)

99 SECOND YEAR Mary Culver Introduction to Surgery Lectures present certain fundamental principles of physiology, biochemistry, and pathology as applied to Department of surgery. Recitations and demonstrations are included. Patient problems are discussed and related to Surgery physiological and biochemical abnormalities. Two hours weekly for 18 weeks during the second and third tri- The Department of Surgery includes general mesters of the second year. surgery, plastic and reconstructive surgery, orthopedic surgery, urological surgery, cardiothoracic surgery, and THIRD YEAR pediatric surgery. The formal instruction begins in the second year with an introduction to surgical principles, Surgical Wards Pathological material is reviewed and considered an the basis of which is largely derived from concepts learned integral part of the case study. At regular intervals the in the pre-clinical sciences. students meet with residents and attending staff in infor- In the third year, students are assigned to clinical mal conferences. In addition, the material is presented to clerkships where they have an opportunity to study the students in small discussion groups with their preceptors. more common surgical diseases. These clerkships last for After discharge students follow their patients in the post- twelve weeks and may be spent at a hospital in the Barnes operative and outpatient clinic. A particular effort is complex or at an allied hospital. Students attend daily made to see that students are exposed to the more com- patient rounds with the house staff and attending staff. mon surgical lesions, and that the assigned cases are Seminars and teaching conferences are scheduled on a sufficiently diversified to afford an accurate perspective of regular basis. surgery. Students are encouraged to consult the library Students are encouraged to assist at operative frequently in the solution of problems concerning procedures involving patients assigned to them. patients. The fourth-year surgical program permits students to select any of the following electives most of which are for periods of six to eighteen weeks: (I) subinternships or FOURTH YEAR preceptorship during which the student is assigned to a The electives offered to senior students are principally staff member for instruction in managing surgical prob- clinical subinternships or research. lems; (2) surgical research (minimum time 12 weeks); (3) Surgical Preceptorships and Subinternships electives in pediatric surgery, thoracic and cardiovascular Each student is assigned to a senior general surgeon. surgery, orthopedic surgery, neurosurgery, urological The student sees patients in the surgeon's office, takes surgery, oncological surgery, transplantation surgery, histories, performs physical examinations, and follows and emergency room surgery. patients in the hospital. (Dr. Etheredge and Staff)

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at liberty to spend time within the cardiac cathcterization laboratory, with members of the cardiopulmonary bypass team, or on any particular problem of acute pulmonary or hemodynamic nature in the Intensive Care Unit. The second alternative is six weeks in the laboratory working on ongoing projects having to do with ischemic heart disease and a myocardial infarction model, prosthetic heart valves, perfusion techniques for infants and the studies of the pulmonary microcirculation. (Dr. Weldon and Staff) Plastic and Reconstructive Surgery Elective This elective offers two tracks, a clinical clerkship or participation in a laboratory project. On occasion, these can be combined if desired by the student. The clinical clerkship is available for six to twelve weeks. Plastic Surgery is divided into five services. The student will rotate on each service for one week. After four weeks, he can elect the services to which he will be assigned. Each service provides a unique opportunity for patient care. Service I—Drs. Marsh and Holtmann congenital anomalies, craniofacial and maxillofacial surgery; Service II—Drs. Weeks and Young—hand surgery and reconstructive plastic surgery; Service III Drs. Wray and Zografakis—reconstructive plastic Surgical Research Elective surgery and microsurgery; and Service IV—resident This elective introduces the student to the general service—general plastic surgery. The student will assist approach to analyzing clinical problems of surgery in the his attendings in the care of out-patients and in-patients, laboratory and familiarizes him with some of the inves- there are three conferences weekly, one reviews patients tigative methods in surgery. In general, the student gains seen the previous week, another permits didactic presen- more experience by working with an established investi- tations by the resident staff, and the third is an x-ray gator on a current project. The student is encouraged, conference. however, to plan and execute a laboratory solution to a The research elective can be for six or twelve weeks, specific problem within the limitations of his elective time. twelve weeks being preferable. Research can pursue The student participates in the weekly departmental projects at either a basic science or clinical study level. research seminars, where investigators describe a wide Basic research done in the Division of Plastic Surgery range of current topics. (Dr. Scharp and Staff) concerns the healing of skin, tendon, and nerve wounds. Pediatric Surgery Elective Many clinical research projects are being conducted by Emphasis is placed on the different problems this age members of the Division of Plastic Surgery. Students are group presents in respect to type of surgical diseases and encouraged to participate in these projects. their care. The student gains exposure to many surgical (Dr. Weeks and Staff) conditions seen only in children. The exposure includes daily morning and evening rounds as well as participation Orthopedic Surgery Elective in the operative procedures. Diagnostic x-rays are Clinical clerkship electives are available for six weeks, reviewed on a daily basis, and the student is encouraged during which time the student attends conferences and to attend the many weekly conferences of the Surgery outpatient clinics and serves in the various orthopedic Department and Pediatrics Department. Students are clinical divisions. It is also possible to establish a research expected to participate actively in clinical care and not elective in the Orthopedic Research Laboratory under the merely to be observers. guidance of Dr. David Simmons. Students on the clinical The student may also elect to spend a portion of the elective become an active part of the orthopedic team and time in an introduction to ongoing research within the may spend part of their time at the Shriners Hospital for Division. Currently, areas of activity include surgical bac- Crippled Children. Veterans Hospital and Barnes Hospi- teriology, short gut syndrome, and experimental animal tal, the exact program to be worked out on an individual fetal surgery. (Dr. Ternberg and Staff) basis with the chairman of the division. (Dr. Schoenecker and Staff) Principles of Thoracic and Cardiac Surgery Two avenues are available which may be mixed. The Urology Elective first involves a clinical rotation on cardiothoracic surgical A six-week clinical clerkship offers the interested stu- service where the students will be assigned duties compar- dent an adequate knowledge of the type of problems with able to that of an intern. They will share night call under which the clinical urologist deals. The student is taught supervision of the first- and second-year residents in rota- the basic diagnostic procedures and the management of tion with the ward interns. They will have the prerogative surgical and nonsurgical patients on both the private and of selection of operative cases on which to scrub and are ward services under the supervision of the attending staff

llll and house officers. The experience involves direct care of student is expected to report to his peers and instructors patients in the clinics, as well as the urologic admissions to on the selected subject at the end of the elective period. the hospital. Daily morning and evening rounds of all Members of the Tumor Committee evaluate the report, as patients on a particular service are conducted by the well as the student's performance during the elective. responsible resident. Two additional teaching rounds for (Drs. Bauer, Philpott, and Staff) the house staff and students are held weekly. In addition, the student attends daily x-ray conferences, the weekly Transplantation Elective staff conference, and the weekly research seminar. The This orientation course is designed to offer the student student is given an opportunity to assist in open and an overview of the entire field of organ transplantation. endoscopic surgery, as well as in the various diagnostic The student is an integral part of the renal transplantation procedures performed in the cystoscopy and urography team and assumes appropriate responsibilities under section. (Dr. Fair and Staff) supervision. (Dr. Anderson and Staff) Oncology Klective Urology Research Elective Students electing to study the theoretical and practical A unique opportunity is afforded the student interested aspects of the epidemiology, diagnosis, treatment and in surgical research to participate in any of the research prognosis of neoplastic diseases in man may select a activities in the Division of Urology. This elective may be program (subject to the approval of the Tumor Commit- structured so as to be meaningful to the student with no tee) which includes interdepartmental experience in sev- previous research experience who desires an exposure to eral of the following areas of knowledge: the techniques and methodology utilized in surgical (a) Surgical pathology of neoplasms. (Dr. Bauer) research. The student may participate in any one of a (b) Neoplasms in children. (Dr. Vietti) number of ongoing projects dealing with the pathogenesis (c) Head and neck cancer. (Dr. Ogura) and etiology of urinary tract infections, mechanisms (d) Radiation therapy of neoplasms. (Dr. Perez) involved in normal and abnormal prostatic growth, urologic oncology with specific emphasis on tumor (e) Hematologic neoplastic disease. (Dr. Reinhard) immunology, the use of prostheses in urology and studies (0 Chemotherapy of solid tumors. (Dr. Philpott) on the etiology of urinary tract calculi. All students attending the oncology elective will be Students with prior investigative experience will be expected to attend the tumor, gynecologic cancer, ENT encouraged to outline and execute a specific laboratory tumor, and neoplastic hematology conferences, as well as problem within the time limitations of the elective. Stu- the cancer workshop. dents will also be invited to participate in all research Each student taking an elective in oncology must select seminars within the Division. (or be assigned) a problem for study in this field. Each (Drs. Fair, Heston and Staff)

Faculty of the Mary Culver Department of Surgery

Bixhy Professor of Surgery, Associate Professor Research Associate Professor t hairman. Department of Surgery John P. Connors, A.B., Holy Cross Ignacio Christlieh, II A. Colegio Samuel A. Wells, Jr., M .1 >. College, 1961; M.D., Georgetown Frances de Preparatoria, 1945; M.D., Harry Edison Professor of Surgery University, 1965. (Jewish Hospital) National Autonomous University of Mexico, 1952. Gordon W. PhilpoH. Ml) (See Division of General Surgcis ) Associate Professors (Clinical) DIVISION OF Martin Bergman, A.B.. Washington DIVISION OF CARDIOTHORACIC SURGERY University, 1942; M.D., 1945. GENERAL SURGERY Head of Division Charles L. Roper, A.B.. Colorado Harry Edison Professor of Surgery Clarence S. Weldon, M.I). College. 1949; M.D., University of Gordon W. Philpott, B.S., Yale Colorado. 1953. University, 1957; M.D., Washington Professors University, 1961. (Jewish Hospital) Richard K. (lark, B.S.E.. Princeton (Cancer Coordinator and Director of University, 1956; MO, Cornell Assistant Professors the Division of Tumor Services, and University. I960; M.D.. University of John P. Marbarger, B.S., University of Head, Section of Surgical Oncology, Virginia. 1962. Illinois. Urbana, 1968; M.D., University Washington University School Clarence S. Weldon, A.B.. University of of Illinois, Chicago, 1974. of Medicine.) Michigan, 1931; M.D.. Johns Hopkins Joseph G, Sandza, B.S.. University of Professors University, 1955. (Sec Department Notre Dame. 1964; M.D., University of Charles B. Anderson, A.B., Johns of Pediatrics.) Puerto Rico. 1969. Hopkins University, 1958; M.D., Yale Professor (I linical) Richard C. Shaw, B.A., State University University, 1962. Thomas B. Ferguson, B.S., Duke of Iowa. 1963; M.D.. Washington Walter F. Ballinger, M.D.. University of University, 1947; M.D.. 1947. University. 1967. Pennsylvania, 1948.

in: I

Harvey R. Butcher, Jr., A.B.. Central G. Lynn Krause, Jr., A.B., Amherst Jerome F. Levy, A.B., Washington I College, 1941; M.D., Harvard College, 1950; M.D., University of University, 1954; M.D., 1958. University, 1944. Pennsylvania, 1954. Stanley L. London, M.D., Washington William W. Monafo, A.B., Harvard Alan M. Londe, A.B., Washington University, 1949. University, 1953; M.D., Tufts University, 1957; M.D., 1961. Sherwin H. Malt, A.B., Washington University, 1957. I Eugene N. Mitchell, B.S., St. Louis University, 1962; M.D., University of University, 1955; M.D., University of Professors Emeriti (Clinical) Missouri, 1966. Missouri, 1960. Eugene M. Bricker, M.D., Washington Jerry R. Meyers, B.A., University of University, 1934. Julian C. Mosley, Jr., B.S., St. Louis Texas, 1962; M.D., Washington University, 1966; M.D., Washington University, 1966. I J. G. Probstein, M.D., Loyola University, 1972. University, 1917. Shale Rifkin, M.D., Washington George A. Oliver, A.B., Washington University, 1948. Associate Professors University, 1948; M.D., 1952. Richard G. Sisson, A.B., Harvard I Laurence Cheung, M.D., National Charles L. Parks, B.A., University of University, 1943; M.D., Yale Defense Medical Center, 1968. (St. North Dakota, 1967; M.D., Washington University, 1946. Louis V.A. Hospitals) University, 1969. Andrew D. Spencer, A.B.. Indiana Thomas H. Covey, Jr., A.N., West Joseph C. Peden, Jr., B.S., Harvard University, 1951; M.D., 1954. Virginia University, 1957; M.D., University, 1940; M.D., 1943. Harvard University, 1961. Mather Pfeiffenberger, Jr., A.B., Yale Instructors Emeriti (Clinical) (Jewish Hospital) University, 1941; M.D., Harvard Virgil O. Fish, M.D., Washington Edward E. Etheredge, B.A., Yale University, 1944. University, 1930 University, 1961; M.D., 1965; Ph.D., George B. Rader, M.D., Washington George C. Wee, M.D., University of University of Minnesota, 1974. University, 1951. Louisville, 1931. John D. Halverson, B.A., Hamilton Frank O. Richards, A.B., Talladega Carl E. Lischer, A.B., University of College, 1963; M.D., State University of College, 1944; M.D., Howard California, 1933; M.D., Washington New York, 1967. University, 1947. University, 1937. Donald C. Sauer, A.B., Washington Associate Professors Emeriti (Clinical) University, 1956; M.D., I960. Associate Professors (Clinical) Heinz Haffner, B.S., University of Ralph J. Graff, A.B., Washington Belmont R. Thiele, M.D., St. Louis Arizona, 1931; M.D., Washington University, 1957; M.D., 1957. (See University, 1948. University, 1935. Department of Genetics.) Marc K. Wallack, B.S., Albright Falls B. Hershey, B.S., University of Instructors (Clinical) College, 1966; M.D., University of Illinois, 1939; M.D., Harvard University, Pittsburgh, 1970. (Head, Section of Robert R. Anscheutz, M.D., 1943. Washington University, 1940 Surgical Oncology, Barnes Hospital.) Robert H. Lund, B.S., Miami John B. Buettner, A.B., Dartmouth Research Assistant Professors University, 1945; M.D., Washington College, 1963; M.D., Washington University, 1949. University, 1967. Harry Margraf, Ph.D., Polytechnicum Milan, 1943; Sc.D., Washington C. Alan McAfee, B.S., Washington Arthur R. Dalton, B.S., University of University, 1971. State College, 1938; M.D., Washington Missouri, 1939; B.S.Med., Northwestern University, 1942. University, 1940; M.D., 1941, Maria Michaelides, B.A., Smith College, 1953; M.A., Radcliffe College, Lawrence W. O'Neal, M.D., Washington Samuel J. Freund, B.S., St. Louis 1954; Ph.D., 1958. University, 1946. University, 1923; M.D., 1927. Leo A. Sachar, A.B., Washington Robert D. Fry, A.B., Oklahoma City Assistant Professors (Clinical) University, 1936; M.D., 1940. University, 1968; M.D., Washington Kenneth J. Arnold, B.A., Notre Dame WilUam D. Schieber, M.D., Washington University, 1972. University, 1964; M.D., Washington University, 1953. Ronald J. Gaskin, A.B., Washington University, 1968. James M. Stokes, M.D.. Washington University, 1966; M.D., 1970. Kenneth J. Bennett, M.D., Tulane University, 1948. Jay W. Haines, B.A., Trinity University, University, 1965. George L. Tucker, A.B., Columbia 1970; M.D., Chicago Medical Richard V. Bradley, M.D., Washington University, 1952; M.D., Harvard School, 1974. University, 1952. University, 1956. Fleming B. Harper, M.D., Medical Cyril J. Costello, B.S., University of Willard B. Walker, M.D., Washington College of Virginia, 1947. Texas, 1935; M.D., 1939. University, 1946. John D. Hirsch, B.A.. Case Western Richard H. Fallon, B.S., Boston Reserve University, 1969; M.D.. College, 1952; M.D., Harvard Assistant Professors Washington University, 1973. University, 1956; A.M., Washington Robert C. Donaldson, A.B., University Robert J. Kingsbury, A.B., Asbury University, 1971. of Missouri, 1941; M.D., Washington College. 1956; M.D., University of Alvin Goldfarb, A.B., Washington University, 1944. (St. Louis Michigan, 1960. University, 1940; M.D., 1943. V.A. Hospitals) David Krajcovic, A.B.. Washington Ira J. Kodner, A.B.. Washington David W. Scharp, M.D., Washington University. 1965; M.D., 1969. University. 1963; M.D., 1967. University, 1970.

[03 Gregorio Sicard, B.S., St. Louis Assistant Professors Instructor University, 1965; M.D., University of Wayne J. Daum, B.S., John Carroll Robert A. Shively, B.S., University of Puerto Rico, 1972. University, 1967; M.D., St. Louis Illinois, 1965; M.D., 1969. Robert J. Stine, B.A., Williams College, University, 1971. Instructors (Clinical) 1964; MAI., Harvard University, 1965; Robert A. Shively, B.S., University of Donald R. Bassman, A.B.. Washington M.D., Vanderbilt University. 1972. (Sec Illinois, 1965; M.D., 1969. University, 1971; M.D., Washington Department of Medicine.) William B. Strecker, B.A., University of University School of Medicine. 1975. Assistants (Clinical) Missouri, 1971; M.D., St. Louis Vilray P. Blair, Jr., University of Arthur I. Auer, B.S., Massachusetts University, 1975. Virginia, 1935; Washington Institute of Technology, 1952; M.D., University, 1939. Washington University, 1956. Assistant Professor Emeritus (Clinical) Donald H. Brancato, B.A.. Leslie K. Bond, A.B., University of J. Otto I.ottes, Ph.B., St. Louis College Northwestern University, 1963; Illinois, 1948; M.D., Meharry Medical of Pharmacy, 1926; Ph.G., 1928; A.B., M.D., 1967. University of Missouri, 1934; B.S., 1935; College, 1952. William S. Costen, A.B.. Princeton M.D., University of Louisville, 1937. Katherinc Crawford, U.S., Michigan University. 1950; M.D.. Washington State College, 1943; M.D.. Woman's University, 1954. Assistant Professors (Clinical) Medical College ol Pennsylvania. 1946. James C. Ellsasser, B.S., Duke Ronald C. Hertel, A.B., Washington James R. Criscione, B.S.. Youngstown University, I960; M.D., Washington University, 1952; M.D., 1956. University. 1943; M.D., St. Louis University, 1964. Barrett K. Holder, B.A.. Southern University, 1951. Jerome J. Gilden, A.B.. Washington Illinois University, 1965; M.D., Dan K. Kopen, B.S., Wilkes College, University, 1948; M.D., 1952. Washington University. 1969. 1970; M.D., Pennsylvania State Robert C. Lander, B.A., University of University, 1974. Jordon H. Ginsburg, B.A., University of Michigan. 1968; M.D.. University of Michigan, 1968; M.D., University of Samuel Lugo, U.S., St. Louis Illinois. 1972. Illinois, 1972. University, 1954; M.D., 1958. Karl P. Holt, Jr., A.B.. Duke University, W. Edward Lansche, A.B., Washington Lester J. Nathan, B.A., University of 1942; M.D., 1945. University, 1948; M.D.. 1952. Omaha, 1949; M.D., University of Charles Mannis, A.B., Washington Nebraska, 1952. Robert E. Kuhlman, A.B., Washington University, 1953; M.D., 1956. University, 1965; M.D., University of Robert Raincy, U.S.. Yale University. Missouri, Columbia. 1969. David R. Lange, A.B., Dartmouth 1944; M.D.. Washington Alan H. Morris, B.A., University of University, 1947. College. 1970; M.D., Washington University. 1974. Illinois, 1959; M.D., 1963. Marvin R. Mishkin, B.A.. Roosevelt Barry L. Samson, B.A.. University of DIVISION OF College, 1950; M.D.. University of Wisconsin, 1970; M.D., Washington ORTHOPEDIC SURGERY Illinois, 1955. University, 1974. Michael H. Winer, A.B.. Washington Acting Head of Division George E. Scheer, B.A.. Municipal University, 1964; M.D., University of Perry I.. Schoeneeker University of Wichita. 1940; M.D.. Washington University, 1943. Illinois, 1968. Professor Emeritus Leo A. Whiteside, B.S., University of Research Instructors Fred C. Reynolds, A.B.. Washington Oklahoma. 1965; M.D., University of Jean E. Childers, B.A.. Cornell College. University, 1931; M.D.. 1934. (Also Texas. 1969. 1965; Ph.D., Rice University, 1970. Professor in Clinical Surgery.)

Associate Professors Lee T. Ford, M.D., University of Tennessee. 1940 Perry L. Schoeneeker, U.S. University of Wisconsin. 1964; M.D.. 1968.

Research Associate Professor David J. Simmons, B.A.. Boston University. 1954; M.D.. Clark University. 1956; Ph.D.. University of Chicago. 1959. Associate Professors (Clinical) Marshall B. Conrad, A.B, Westminster College. 1942; M.D.. Washington University. 1945. Harry C. Morgan, B A . I nuersity ot Missouri, 1949; B.S.. 1951; M.D.. Harvard University. 1953.

104 S. Vic Glogovac, A.B.. Washington Assistant Professors Professor (Clinical) University, 1969: M.D.. 1973. John J. Delfino, B.S., Holy Cross Robert K. Royce, B.S.. University of Assistants (Clinical) College. I960; D.D.S., Temple Mississippi, 1939; M.D.. Washington John P. Arnot, B.A., Rice University. University, 1967. (Also School of University, 1942. Dental Medicine.) 1954; M.D., Yale University, 1958. Associate Professors Barbel Holtmann, B.S.Ed., A.B., Kyu Sop Cho, M.D.. Yon-Sei William J. Catalona, B.S.. Otterbein University of Missouri, 1964; M.D., University, 1954. College, 1964; M.D., Yale Medical 1968. (See Department of Pediatrics.) Herman E. Russell, B.A.. New York School, 1968. Jeffrey L. Marsh, B.A., Johns Hopkins University, 1950; M.D., University of Charles B. Manley, Jr., A.B.. University University, 1967; M.D., 1970. (See Geneva. 1956. of Missouri, 1955; M.D.. 1958. (See Department of Pediatrics.) George R. Schoedinger III, M.D., Department of Pediatrics.) Vernon Leroy Young, B.A., University University of Oregon, 1962. Gerald Sufrin, B.S.. University of of Kentucky, 1966: M.D., 1970. Pennsylvania, 1960; M.D., State DIVISION OF University of New York, Upstate, 1966. PEDIATRIC SURGERY Assistant Professors (Clinical) Joseph W. Eades, A.B., Amherst Associate Professor Emeritus (Clinical) Head of Division College. 1952; M.D.. Washington Carl A. Wattenberg, A.B., University of Jessie L. Ternberg, M.D. University. 1960. Kansas, 1934; M.D., 1937. Professor George H. Zografakis, M.S., Rutgers Jessie L. Ternberg, A.B., Grinnell University, 1955; M.D., State University Associate Professors (Clinical) College, 1946; Ph.D., University of of New York. Upstate, 1959. Morris Abrams, B.S., University of Texas, 1950; M.D., Washington Illinois. 1934; M.D., 1937. University, 1953; Sc.D. (hon.), Grinnell Instructor William T. Bowles, A.B.. Stanford College, 1972. (See Department Susan H. Barcus, A.B.. Cornell University. 1952; M.D., 1955. of Pediatrics.) University. 1970: M.D., University of M. Richard Carlin, B.A., Dartmouth Associate Professor Rochester. 1975. College. 1944; M.D.. Yale Martin J. Bell, B.A., New York University, 1947. University. 1959; M.D.. State University Instructors (Clinical) Assistant Professors of New York. Downstate. 1963. (See David A. Caplin, A.B., Kenyon College, Leonard D. Gaum, Pre-Medical, Department of Pediatrics.) 1971; M.D., University Cincinnati. 1975. Dalhousie University, 1968; M.D., 1972. Assistant Professor Henry Ollinger, A.B., University of Mani Menon, B.S., St. Thomas College, Richard J. Bower, B.S.. Northern Missouri, 1967; M.D., 1971. 1964; M.D., Madras University, 1969. Illinois University, 1965; M.D., William C. Sharer, B.A.. Princeton University of Virginia. 1969. (See Richard Shatz, B.A., University of University. 1968; M.D.. Northwestern Department of Pediatrics.) Missouri. 1968; M.D.. St. Louis University. 1972. University. 1972. Research Assistant Professor Bruce I. White, M.D., Washington Research Assistant Professors Paul R. Manske, B.A., Valparaiso University. 1964. University. I960: M.D., Washington Warren D. Heston, Ph.D., University of University, 1964. Colorado, 1968. Consultant in Oral Surgery Research Associate Richard F. Parrish, B.S.. Southern Leroy W. Peterson, D.D.S., University Illinois University, Edwardsvillc. 1969; Peggy A. Lesker, B.A.. Illinois of Michigan, 1940. (Also School of College. 1965. M.S., 1970: Ph.D., Iowa State Dental Medicine.) University, 1976. Timothy L. Ratliff, B.S., University of DIVISION OF PLASTIC AND Consultant in Texas. 1971; M.S., East Texas RECONSTRUCTIVE SURGERY Speech Pathology in Surgery University. 1974; Ph.D.. University of Head of Division (Plastic and Reconstructive Surgery) Arkansas. 1977. Paul M. Weeks, M.D. Richard Merson, Ph.D.. University of Franz U. Steinberg, M.D.. University of Professor Wisconsin. 1970. (Also School of Dental Medicine.) Berne. 1938. (See Departments of Paul M. Weeks, A.B., Duke University, Medicine and Preventive Medicine and 1954; M.D.. University of North Public Health.) Carolina, 1958. (See Irene Walter DIVISION OF UROLOGY George E. Swaneck, B.S.. Universidad Johnson Institute of Rehabilitation.) Catolica. 1958; M.D.. 1962. Professor Emeriti (Clinical) Head of Division (Jewish Hospital) Minot P. Fryer, A.B.. Brown University. William R. Fair, M.D. Assistant Professors (Clinical) 1936; M.D.. Johns Hopkins University. Professors 1940: D.S.C.. Brown University, 1972. James G. Bucy, B.S., Haverford Saul Boyarsky, B.S.. University of College, 1958; M.D., Northwestern Associate Professor Vermont. 1943; M.D.. 1946. University, 1962. Robert C. Wray, Jr., B.S.. University of William R. Fair, B.S.. Philadelphia Richard P. Parsons, B.D.. Missouri Arkansas. 1961: M.D.. Washington College of Pharmacy. 1956: M.D., Valley College. 1954; M.D., Washington University. 1963. Jefferson Medical College, 1960. University. 1958.

10? r. r. Instructor Dov Kadmon, Pre-Medical, Hebrew University Hadassah Medical School, l%6; M.D., 1970. Instructors (Clinical) Lawrence M. Aronberg, A.B., Washington University, 1932; M.I) . 1936. J J. Byron Beare, B.S., St. l.ouis University, 1936; M.D., 1939; M.S., .. University of Minnesota, 1947. Saul Klein, M.I)., Syracuse University Medical Center, 1959. Neal Neuman, Ml) St. l.ouis University, 1971. Herbert Sunshine, A.B.. Washington University, 1950; M.D., 1954. Research Associates ROM Boyarsky, B.S.. University of Vermont. 1944; M.A.. Columbia University, 1946; Ph.D., Duke University, 1969. Kainasainy Selven, B.Sc, St. Xavior, I96X; M.Sc, Madras University, 1970; Ph.D., Madras University, 1975. Research Assistant Carl Mahle, U.S.. University of Maryland, 1974.

lilt- used is MUMPS (MGH Utility Multi-Programming Teaching and System). Three hours of class work plus laboratory each week for six weeks. Research Divisions (Dr. Blaineand Staff) Introduction to Programming a Laboratory Computer Topics covered are: generalized description of digital BIOMEDICAL COMPUTER LABORATORY computer architecture, organization and implementa- The Biomedical Computer Laboratory collaborates tion; introduction to a minicomputer operating system; with research investigators at the Medical Center in the programming technique and structure; and input/ output application of modern information processing techniques programming. The PDP-11 minicomputer with the to problems in biology and medicine. The laboratory RSX-11M operating system is used for laboratory work- currently has active programs in real-time and high-speed shops. Prior knowledge of FORTRAN is helpful but not ECG analysis, clinical pathophysiologic research, tomo- required. (Dr. Blaine and Staff) graphy, central nervous system diseases and encephalo- Computers in Medicine gram analysis, speech synthesis and models of cochlear This course will cover selected topics related to the function and patient-based medical information systems. spectrum of computer technologies (large-scale compu- Research and training are offered to medical and ters through microcomputers) used in both research and graduate students in mathematical techniques, digital clinical medicine. Topics include medical information system design, and advanced programming techniques management, acquisition of laboratory data, large-scale applied to the biomedical problems described above. computation and language options. Only a minimal Opportunities to carry out research are available to stu- background in mathematics and electrical theory is dents who have completed the first year of the medical assumed. Three class hours each week. Demonstrations school curriculum and to graduate students on a year- and laboratory exercises provde an opportunity for round basis. A number of assistantships are available. "hands-on" experience. (Dr. Blaine and Staff) The laboratory participates in the interdepartmental programs in Biomedical Engineering and Health Care Technology. The Biomedical Computer Laboratory is affiliated with the Computer Systems Laboratory located in nearby quarters at the School of Medicine. The mission of the Computer Systems Laboratory is the design and development of advanced computer systems with a current focus on the development of modular processors. These systems are being applied to molecular and neural modeling, electrocardiographic rhythm analysis and speech synthesis.

BMed 582. Biophysical Measurements (Same as EE 582) Specific variables measured in life-science research and in clinical medicine such as force, displacement, pressure, biopotentials, ion and gas concentrations, flows, etc., are examined and techniques for converting them to electrical signals are disscussed. Prerequisites: EE 482 or equivalent, elementary electromagnetic theory. Credit 3 units. (Prof. Shipton) BMed 693. Physical and Mathematical Principles of Tracer Kinetics Theoretical foundations of tracerkinetic methods. Topics covered are differential equations for conservation of tracer mass, applications of elementary linear systems theory, stochastic and compartmental models, methods of accounting for tracer recirculation and methods of data-processing. (Dr. Larson) Programming for Medical Information Systems An interpretive language designed for medical information systems is described, with programming examples from hospital and ambulatory care settings. The language

107 Associate Professor and Director l*wis J. Thomas, Jr., B.S., Haverford College, 1953; M.D., Washington University, 1957. (See Departments of Anesthcsiology and Physiology and Biophysics.) Professors and Senior Research Associates Jerome R. Cox, Jr., SB., Massachusetts Institute of Technology, 1947; S.M., 1949; Sc.D., 1954. (See Department of Physiology and Biophysics.) (Also School of Engineering and Applied Science.) Harold W. Shipton, C.Eng., Shrewsbury Technical College, 1949. (Also School of Engineering and Applied Science.) Donald 1.. Synder, B.S., University of Southern California, 1961; M.S.. Massachusetts Institute of Technology, 1963; Ph.D., 1966. (Also School of Engineering and Applied Science.) Associate Director G. James Blaine III, B.S.. Washington University, 1959; M.S., 1961; D.Sc, 1974. (Also School of Engineering and Applied Science.) Professors G. Charles Oliver, A.B., Harvard University. 1953; M.D., 1957. (See Department of Medicine.) Donald L. Snyder, B.S., University of Southern California. 1961; M.S., Massachusetts Institute of Technology, 1963; Ph.D., 1966. (Also School of Engineering and Applied Science.) Associate Professors James G. Dunham, B.S.. Stanford Kenneth B. Larson, Met.E., Colorado R. Martin Arthur, B.A., Rice University. 1973; M.S., 1973; Ph.D., School of Mines, 1954; S.M., University, 1962; B.S., 1963; M.S.. 1964; 1977. (Also School of Engineering and Massachusetts Institute of Technology. Ph.D.. University of Pennsylvania, 1968. Applied Science.) 1958; Ph.D.. 1964. (Also School of Engineering and James G. Miller (Physics), St. Louis Applied Science.) A. Maynard Engebretson, B.S.. University of Minnesota. 1958; M.S., University. 1964; M.A., Washington William K. Holmes, A.B.. Princeton Washington University. 1963; D.Sc. University, 1966; Ph.D., 1969. (See University, 1953; Ph.D.. University of 1970. (Also Central Institute for Department of Medicine.) (Also Faculty Pennsylvania. I960. (See Department of the Deaf.) of Arts and Sciences.) Biological Chemistry.) Assistant Professors Research Associates Ronald W. Hagen. B.S.. University of Minnesota, 1964; M.S., St. Louis Rexford L. Hill, B.S.. University of Robert J. Arnzen, B.S.. Washington Cincinnati. 1964; M.S., 1966. (See University. 1970. (See Department University. 1964; M.S.. 1966; Ph.D.. Department of Radiology.) of Surgery.) 1969. (Also Computer Systems J. Philip Miller (Biostatistics). A.B.. Laboratory.) Richard E. Hitchens, B.S.. Washington Washington University. 1965. (See Kenneth W. Clark, B.S., St. Louis University. 1969. (Also School of Department of Preventive Medicine and University, 1965; M.S.. 1967. Engineering and Applied Science.) Public Health.)

I OS THE MEDICAL CARE GROUP OF ST. LOUIS MCG is a source of data for various clinical and (MCG) health services research. M CG is a prepaid group practice providing compre- The practice is staffed by physicians who arc mem- hensive health services to more than 21,000 members. bers of the faculty of the School of Medicine in the Since its beginning eleven years ago, MCG's relationship Departments of Internal Medicine, Pediatrics, Preventive with the School of Medicine has been as a teaching and Medicine, and Obstetrics and Gynecology. They are sup- research unit serving as a model practice setting within a ported by medical, pediatric, and obstetric nurse practi- medical school environment. It is housed in a separate tioners as well as physician's assistants, psychiatric social facility on the medical school campus. The practice is a workers, a dietician, and an optometrist. Subspecialty site for optional programs for advanced residents in gen- care is delivered by other members of the faculty in the eral internal medicine and general pediatrics. An elective various clinical departments of the School of Medicine. is available for senior medical students.

Director Michael B. Gutwein, A.B., Harvard Richard LazarofT, B.A.. Brown Lawrence I. Kahn (Health Care University. 1969; M.D., Washington University, 1974; M.D., St. Louis Research), A.B., University of Alabama, University, 1974. (See Department University, 1978. (See Department 1941; M.D.. Louisiana State University. of Medicine.) of Pediatrics.) 1945. (See Departments of Pediatrics Carl G. Harford, A.B.. Amherst Jerald Maslanko, M.D., Emory and Preventive Medicine and Public College. 1928; M.D., Washington University, 1975. (See Department Health.) (Also Pediatric Nurse University, 1933. (See Department of Medicine.) Practitioner Program.) of Medicine.) Edward G. Peskin, B.A.. University of Staff Will Holcomb, B.A.. Purdue University, Wisconsin, 1970; M.M.S., Rutgers Marion H. Baker, R.N., St. John's 1970; M.D., Indiana University, 1974. University, 1972; M.D., Washington Hospital, 1946; P.N.P., Cardinal (See Department of Obstetrics University, 1974. (See Department of Glennon Memorial Hospital for and Gynecology.) Obstetrics and Gynecology.) Children. 1973. (See Department Chinda Vanasin Rojanasathit, M.D., of Pediatrics.) Janet D. Hoy, B.S., Carroll College, Siriraj Medical School. 1968. 1975; P.A., St. Louis University, 1977. Allan S. Brett, B.A., University of (See Department of Medicine.) Paul S. Simons, B.A., University of Pennsylvania, 1972; M.D., 1976. (See Texas 1963; M.D.. Washington Department of Medicine.) Clemens H. Jacques, B.S., University of University, 1967. (See Department Jeanette M. Broering, B.S.N., St. Louis California. 1949; O.D.. 1949. (See of Pediatrics.) Department of Ophthalmology.) University, 1974; P.N.P., Cardinal Kongsak Tanphaichitr, M.I).. Siriraj Glennon Memorial Hospital, 1976. (See Kwangsup S. Kim, M.D., Seoul Hospital Medical School, 1970. (See Department of Pediatrics.) National University, 1963; Ph.D., 1970. Department of Medicine.) Max H. Burgdorf, Jr., A.B., (See Department of Medicine.) James K. Turner, A.B., Washington Washington University. 1970; M.D., A. Donna King, B.A., Western University, 1949; M.D., 1953. (See 1974. (See Department of Pediatrics.) Maryland College. I960; M.S.W., Department of Pediatrics.) John J. Garrett, B.S., Niagara Washington University, 1966. (See Elsie Winstead, B.S., East Carolina University, 1942; M.D., Harvard Department of Preventive Medicine University, 1973; M.D., University of Medical School, 1951. (See Department and Public Health.) North Carolina 1977. (See Department of Medicine.) Donald K. King, A.B.. Fairfield of Medicine.) Guner B. Gulmen, M.D.. Hacettepe University. 1966; M.D., Johns Hopkins Patricia B. Wolff, B.A.. University of University Medical School, 1969. (See University, 1970. (See Department Minnesota, 1968; M.D., 1972. (See Department of Medicine.) of Medicine.) Department of Pediatrics.)

109 [ c BEAUMONT-MAY INSTITUTE OF students are assigned to the tumor clinics of the various NEUROLOGY services, where they gain firsthand experience with The Beaumont-May Institute of Neurology was cancer. established in 1955 by gifts from the Louis D. Beaumont Interdepartmental tumor conferences, held each [ foundation, Mrs. Charles M. Rice, and Morton J. May. week for members of the junior class, postgraduate stu- It is the purpose of the institute to foster basic and clinical dents, visitors, and staff, serve as a forum to demonstrate research in neurology, with special reference to defects in some of the complex problems in diagnosis and therapy the structure of the nerve cell which occasion important which arise in patients with malignant disease. Other c neurological disorders having a high incidence of pro- tumor conferences are held at regular intervals by the longed disability. various clinical departments. In the senior year, students may elect periods of study which expose them to the theoretical and practical [ DIVISION OF TUMOR SERVICES aspects of the epidemiology, diagnosis, treatment, and The Division of Tumor Services was organized by prognosis of various human neoplasms. This program is the coordinating committee for the cancer education pro- tailored to the particular interests of each student with the gram. Cancer, like many other subjects in the medical approval of the executive committee of the Division of [ curriculum, is taught in an interdepartmental manner. In Tumor Services. The oncological electives available to the sophomore year, a six-week interdepartmental course seniors include studies in any of the following fields: in hematology and oncology is taught as part of the surgical pathology, neoplasms in children, surgical pathophysiology course by members of all clinical depart- oncology, radiation therapy, hematologic neoplasms, and [ ments which participate in the division. In the junior year, epidemiology of cancer.

( ancer ( oordinator, Director of Neurology and Neurological Surgery Pathology [ Division, and ( hairman of William S. Coxe Walter C. Bauer Executive ( ommittee Obstetrics and Gynecology Pediatrics Gordon W. I'hilpott H. Marvin Camel Teresa J. Vietti Ming-Shian Kao Radiology [ Executive ( ommittee Ophthalmology Fransiska Lee I nesthesiology ■ Morton E. Smith Carlos A. Perez William I). Owens Otolaryngology Surgery Internal Medicine Joseph H. Ogura Harvey R. Butcher, Jr. [ Stuart A. Kornfeld Donald G. Sessions Gordon W. Philpott [ [

110 r i

THE IRENE WALTER JOHNSON INSTITUTE L OF REHABILITATION The teaching of rehabilitation is conducted by the Department of Preventive Medicine and Public Health in collaboration with various specialty services. The Irene L Walter Johnson Institute of Rehabilitation is a modern, five-story facility that is air-conditioned and well equipped for the care of disabled patients. Students of medicine, house officers, and students of paramedical services have an opportunity to affiliate with the institute. Traineeship Elective ] Traineeships in Physical Disability and Rehabilita- tion of eight weeks' duration may be elected during the interval between the end of spring semester and beginning of the fall semester by two students who have completed ] the first year of the medical school curriculum. Specific instruction is given by means of informal lectures, demonstrations, and seminars. The student becomes familiar with the techniques for defining the extent of physical ] disability and with various approaches to its treatment. Emphasis is placed on methods used in physical, occupational, and speech therapy, and on the specialized contributions to be made by rehabilitation, social work, nurs- ] ing, and vocational testing and counseling. Opportunity is made available for special emphasis on the rehabilitation of hand injuries and for participating in research activities of the Rehabilitation Engineering Unit. ] Interests of the students will be met by arranging experience in rehabilitation medicine at extramural facili- 1 ties, including Jewish Hospital and Paraquad. Director Michael H. Brooke, MB., B.Ch., Cambridge University, 1958. (See Departments of Neurology and ] Neurological Surgery and Preventive Medicine and Public Health.) Associate Director Sven G. Eliasson, Ph.D., University of ] Lund, 1952; M.D., 1954. (See Department of Neurology and Neurological Surgery.) Assistant Director ] James Carroll, B.S., University of Louisville, 1966; M.D., 1969. (See Departments of Neurology and Neurological Surgery and Pediatrics.) ] Director of Milliken Hand Rehabilitation Center Paul M. Weeks, A.B., Duke University, 1954; M.D., University of North ] Carolina, 1958. (See Department of Surgery.) Director of the Cardiac Rehabilitation Center ] Ali A. Ehsani, M.D.. Tehran University, 1956. (See Departments of Medicine and Preventive Medicine and Public Health.) ] Ill Graduate Training

DIVISION OF BIOLOGY AND BIOIMKDICAL SCIENCES The Division of Biology and Biomcdical Sci- ences, formed in the summer of 1973, was established because of the realization that trainingand research in modern biology transcend the limits of departmental structure. I he faculty consists of members of preclinical departments of the School of Medicine: Anatomy and Neurobiology, Biological Chemistry, Genetics, Microbiology and Immunology, Pathology, Physiol- ogy and Biophysics, and of the Department of Biology of the Faculty of Arts and Sciences. For purposes of graduate training, the Division is divided into the following programs: Integrative and Cell Biology, Molecular Biology, Neural Sciences, Plant Biology, and Population Biology. The faculty in each of these programs participates in the presentation of divisional courses and sets the requirements for the Ph.D. degree within the programs. These courses arc also available to medical students AS senior elective*. The Ph.D. requirements in all programs are highly flexible. They include courses which are adjusted to the student's background and interest, qualilvingexaminations usually taken during the second year, execution of original research suitable of the following courses: biology, genetics, chemistry for a dissertation, and defense of the thesis. Graduate (general, analytical, organic, and physical), physics, students are admitted to the Division as students-at- and calculus. It is possible for the student, in excep- large for the first year of their training. During the first tional cases, to fill some lack of basic entrance require- year, advisers are appointed to assist students in select- ments for the specific program by electing these ing courses and to help them become acquainted with courses in the beginning year of study. It is strongly the various research programs in the Division. At the recommended that the applicant take the Graduate conclusion of the first year, it is expected that students Record Examination, both the aptitude and advanced will make a decision as to which program they wish to portions. Additional information and the application join and, by choosing a research adviser, will be for admission may be obtained by writing directly to located in one of the departments which make up the the Office of Graduate Student Affairs, Box 8072, Division. Alternatively, graduate students may also Washington University School of Medicine, 660 S. select training programs within the disciplines repres- Euclid Avenue, St. Louis, Missouri 63110. ented by the departments; the Ph.D. degree require- For the 1982-83 academic year, the tuition and ments for these students will be determined by the health fee in the Graduate School of Arts and Sciences individual departments. In order to obtain expertise in will be $3,702.50 a semester for full-time study. For teaching as well as research, all students serve as teach- students enrolled for fewer than twelve units, the rate ing assistants for two semesters during their graduate is $295 a unit. Graduate students who are enrolled for training. more than six units per semester in courses at the Students in the Ph.D. program will receive full Medical Centerare required to participate in the Med- tuition remission and stipends at the level of $5,500. In ical Center Student Health Service. The health fee is main eases the award is made from an Mil training payable each semester at the time of registration. As grant and is subject to the payback agreement and noted above, these charges are usually covered by tui- taxability provisions appropriate to such awards. tion remission. Applications for admission are due no later than The following graduate courses are offered by the January 31 for matriculation the following summer or Division of Biology and Biomedical Sciences. Those fall. Admission is based on demonstrated ability, courses which are particularly relevant to any given future promise, and the number of openings currently department are cross-listed under that department in available. In general, a student should have completed this Bulletin. The faculty member in charge of the undergraduate training in biolog>. ehemistrj ,01 phys- course and his departmental affiliation are shown at ics at a high scholastic level and have completed most the end of each course. it: i I

Bio 401. Vertebrate Physiology will include group or individual participation in a research Two hours each week will be devoted to an examina- problem or problems dealing with individual aquatic I tion of the functional anatomy and the function of the components of the aquatic environment or their inter- great organ system of the mammal (exclusive of the action. Prerequisite, permission of instructor. Limited nervous system and the reproductive systems). One enrollment. Credit 4 units. (Nichols [Biology]) hour will involve discussion of the pertinent phylogeny I and important variations in the particular system Bio 4131. Laboratory Tutorial on Plant Development under study. Prerequisite, general chemistry, physics Modern tools and techniques for research on growth, and college algebra or their equivalents. Credit 3 units. development, and regulation of higher plants. Prerequi- (Staff [Physiology and Biophysics]) site, Bio 299, Chem 252 and 257. Consent of instructor required. Two afternoons a week or equivalent. Credit Bio 404. Laboratory of Neurophysiology 2 units. (Beachy [Biology]) Elements of the nervous system, neural analysis of sensory information and organization of neural activ- Bio 4141. Laboratory Tutorial on Plant Physiology ity will be electrophysiologically studied by students to Modern tools and techniques for research on metabo- find out how some of the interesting experiments in lism and physiology of higher plants. Prerequisite. Bio neurophysiology are actually performed. Resting and 299. Chem 252 and 257. Consent of instructor required. action potentials, excitation transmission, sound- and Two afternoons a week or equivalent. Credit 2 units. photo-reception, organized activity of motoneurons, Varner (Biology) analysis of human and animal sounds, and psycholog- Bio 415. Theoretical Population Genetics ical phenomena will be examined. Credit 3 units. A rigorous introduction to the theoretical basis of (Suga [Biology]) population genetics and evolutionary mechanisms. Bio 405. Physiological Basis of Acoustic Quantitative genetics and population structure will be Communication investigated first, followed by an examination of how Lectures and seminars in hearing of various species selection, population structure and ecological factors of animals, including humans. Structural and func- interact in determining the evolutionary fate of a popula- tional adaption to the environment in which their tion. Credit 3 units. (Templeton [Biology]) acoustic communication is performed is considered. Not only auditory physiology, but also sound produc- Bio 416. Evolutionary Biology tion, acoustic communication, and echolocation in Individual areas of evolutionary biology will be dis- bats will be discussed. Demonstrations of neural cussed in depth. Topics will include the Biological Species responses to acoustic stimuli will be included. Credit concept, the hypothesis of selective neutrality of enzyme 2 units. (Suga [Biology]) polymorphism, modern concepts in systematics, molecular approaches to the study of adaptation, the coevolution Bio 408. Human Evolution of insects and plants, and other topics of current evolu- The fossil evidence for human and nonhuman pri- tionary interest. Credit 3 units. (Johnson [Biology]) mate evolution. Classification and genetics in evolutionary perspectives, relations between biology and Bio 417. Mathematical Ecology culture in ancient and modern populations. Prerequi- The theory of the Leslie Matrix will be developed with site, Anthro 150 or one 100-level biology course. respect to population growth, colonization, demography (Molnar [Anthropology]) and evolution of life history attributes. Matrix approaches will next be used to study species interactions Bio 410. Molecular Virology and communities. Finally, the use and limitations of A comprehensive study of the virus world—includ- optimization models in ecology will be discussed. Credit ing animal, plant, and bacterial viruses—with empha- 3 units. (Templeton [Biology]) sis on the molecular biology of virus structure and replication. This course is for advanced undergraduate Bio 4181. Population Genetics and graduate students, who are expected to read orig- An introduction to the basic principles of population inal papers and participate in discussion groups. and ecological genetics. The mechanisms of microevolu- Credit 3 units. (M.J. Schlesinger, tionary processes are discussed, and an integrated ecolog- S. Schlesinger. Beachy ical and genetic approach is used to study the adaptive [Microbiology and Immunology]) nature of the evolutionary process. Credit 3 units. Bio 411. Phycology (Templeton [Biology]) A systematic treatment of the freshwater and Bio 419. Ecology marine algae. Emphasis primarily on morphology, A survey of ecological principles underlying the spatial physiology, taxonomy, and genetics of the major and and temporal distribution of populations and biological minor algal groups. Certain aspects of recent research communities. Credit 3 units. (Sexton [Biology]) and present problems in phycology will be considered. Credit 4 units. (Nichols [Biology]) Bio 4201. Selected Topics in Life History: Strategies of Tetrapod Vertebrates Bio 412. Experimental Aquatic Biology Lectures, discussions and field trips devoted to the Studies of current research problems and research analysis of vertebrate life tables, growth, reproductive techniques devoted to aquatic flora and fauna. The course cycles, predation and distribution in space and time, with

113 special reference to amphibians and reptiles. Individual Bio 441. Problems in Developmental Biology research projects will be required. Credit 3 units. Examination of a variety of problems related to orga- (Sexton [Biology]) nismic development (such as cell-cell interactions, pattern formation and the regulation of gene expression) based Kio 424. Immunology largely on in-depth discussion of selected research papers. I he basic molecular and cellular aspects of the verte- Prerequisite, Bio 301, Bio 302, or consent of instructor. 3 brate immune response, emphasizing the specificity of antibody reactions, the molecular structure of antibodies, class hours a week. Credit 3 units. (Yao [Biology]) the genetic origin of their diversity, and the cellular basis Bio 446. Biology of the Fungi of their formation. Other topics will include tolerance, General aspects of the biology of the major fungal autoimmunity, allergy, blood groups, immunogenetics, groups, including their development, genetics, cytology, anil tissue transplantation. Credit 3 units. metabolism and ecology. Roles these microorganisms (Fleischman [Microbiology and Immunology]) play in nature, research, medicine, and agriculture. Pre- Bio 425. Microbial Physiology requisite, 6 units of Biology and permission of instructor. An in-depth coverage of selected topics in microbial Two class hours and one laboratory period a week. Credit physiology and molecular biology. Topics may vary from 3 units. (Maniotis [Biology]) sear to year but could include cell regulation and growth, Bio 448. Plant Systematics Workshop bioenergetics, sporulation, bacterial genetics, plasmid A series of workshops, each consisting of laboratories structure, and recombinant DNA research. Credit 3 units. and tutorials for advanced undergraduates and graduates (Silver [Biology]) contemplating careers in systematics, ecology or natural Bio 428. Developmental Neurohiology history: Section 1—monographic studies; Section 2— 1 ectures and assigned reading, including original liter- cytotoxonomy; Section 3—palynology; Section 4— ature, will be used to explore in some detail the basic microtechnique: Section 5—chemosystematics. Credit 1 principles of the development of the central and peri- or 2 units for each section. Staff (Biology) pheral nervous system. Subjects will include classical Bio 450. Topics in the History of Eugenics experimental neuroembryology. spinal cord develop- A research seminar in which students will carry out ment, neuronal differentiation and axonal growth, neural in-depth research projects on eugenics movements in the crest derivatives, gliogenesis, myelination. synaptogene- United States or Europe (1890-1960). Topics can include: sis, specificity, trophic interactions, cortical development genetic basis of eugenic theories, funding of the Eugenics and regeneration. Credit 3 units. (M. Johnson Movement, connections between U.S. and other (e.g., & Neuroscience faculty [Anatomy and Neurohiology]) Nazi) eugenics movements, etc. Credit 3 units. (Allen [Biology]) Bio 435. History of Biology and Kelated Sciences, Bio 451. General Biochemistry Antiquity through the Seventeenth Century See Department of Biological Chemistry. The first of two semesters, this course will cover the basic development of the life sciences from antiquity Bio 4521. Experimental Molecular Biology through the scientific resolution. Emphasis will be placed laboratory designed to provide experience in current on the interaction of biology with physics, chemistry, techniques and principles of molecular biology with cosmology, philosophy and the social sciences. The emphasis on molecular genetics, protein synthesis, nucleic course is approached from a Marxist perspective. Credit 3 acid structure, gene expression, cloning and sequencing units. (Allen [Biology]) methods. Precise topics and instructors will be announced yearly. Credit 3 units. Frazier, Staff (Biochemistry) Bio 436. History of Biology and Kelated Sciences from Bio 453. Basic Principles of Nucleic Acids and the Seventeenth Century to the Present Protein Synthesis I he second of two semesters, this course covers the A study of the basic principles of DNA replication, development of the life sciences from the seventeenth RNA synthesis, and protein synthesis. Credit 1 unit. through the mid-twentieth centuries. Emphasis will be (Morris [Biology], Staff) placed on the development of biology, and its interactions with physics, chemistry, astronomy, philosophy, and the Bio 454. History of Genetics social sciences I he course is approached from a Marxist A seminar dealing with selected topics in the history of perspective. Credit 3 units. (Allen [Biology], Hall) genetics, focusing largely on the period since 1900. The first part of the seminar (weeks 1-7) will be devoted to Bio 437. laboratory on DNA Manipulation exploration of specific topics (with primary and sec- Isolation ot DNA. use o\ restriction endonucleases, ondary source readings) such as: the background devel- electrophoretic separation of DNA fragments. Southern opment of Mendel's work, cytology (1860-1930); the bio- blotting, in vitro labeling of nucleic acids and DNA metrical movement, heredity and evolution (1860-1900): hybridization are covered. A molecular cloning experi- the rediscovery of Mendel, the chromosome theory and ment employing colons hybridization is performed by- the Morgan school, Mendelism and Darwinism (1900- each student. Prerequisite, either a biochemistry labora- 1940); biochemical genetics, molecular genetics, the tory course or a microbiology laboratory course: enroll- Eugenics Movement (1890-1940). The second part of the ment limited, consent of instructor required. Credit 3 course will be devoted to presentation and discussion of units. (Chilton [Biology]) student research papers. Credit 3 units.(Allen [Biology])

114 J I J Bio 455. Neurocytology Bio 4851. Physiological Ecology of the Vertebrates A consideration at the light and electron microscopical An examination of the adaptations of organ and sys- level of the structure of neural tissues, including neurons tem physiology in the vertebrate which enable the animal and their processes, synapses, glial cells, myelin, etc., and to exploit difficult environments. Students will partici- their reaction to experimental injury. Lectures and labor- pate in a team project on behavioral thermoregulation atory. Prerequisites, Bio 341, Bio 544, or consent of involving biotelemetry of body temperature and location instructor. Credit 2 units. from free living vertebrates at Tyson. Credit 3 units. Bio 458. Neurobiology and Biophysics of the Ear (Coles [Biology]) Discussion of the following topics: structure of various Bio 493. Seminar in Advanced Biology components of the ear; acoustic phenomena in the ear Topics tend to cut across disciplinary lines within biol- canal that are biologically generated inside the inner ear; ogy. Topics, staff and prerequisites vary from semester to biomechanics of the middle ear and the inner ear; neuro- semester and are announced during the prior preregistra- biology of the sensory hair-cells; biological control of the tion period. Credit to be arranged. motion of cochlear partition; response patterns of single (Staff [Biology]) cochlear neurons to various sound stimuli; clinical appli- Bio 4931. Vertebrate Structure cations of ear-canal acoustic phenomena and auditory A functional and comparative approach to the gross evoked potentials; use of computers in conducting neuro- and microscopic anatomy of the vertebrates. The major physiological experiments and in systematically interpret- organ systems, excluding the nervous system, are exam- ing the data. Prerequisite, consent of instructor. Three ined. A special project is assigned. class hours a week plus occasional laboratory demonstra- (Krukowski [Biology]) tions of animal experiment. Credit 3 units. (Kim, Molnar [Physiology and Biophysics]) Bio 500. Independent Work Prerequisite, junior or senior standing, consent of the Bio 459. Vision sponsor and the department. Credit to be determined in A course designed to bring together the anatomy, phy- each case. Maximum of 6 units may be applied toward siology, and psychology of vision to provide an under- upper-division credits required for the major. If the work standing of function. Properties of light and receptors will is to be submitted for honors, further requirements are a be covered, and analysis of form, movement, color and B+ average in biology courses, a B+ average in related depth in the vertebrate visual system, with some material subjects required for a biology major, a B+ average over- on invertebrates. Credit 3 units. (Daw [Physiology all, and registration for 3 units in each of 2 semesters; an and Biophysics], Cohen, Miller, Pearlman) honors thesis must be prepared. Credit/ no credit only. Bio 467, 468. Seminar in Floristic Taxonomy (Staff [Biology]) A survey of angiosperm families, their morphology, Bio 501. Human Anatomy cytology, anatomy, palynology, chemistry and evolution. See Department of Anatomy and Neurobiology. Credit 1 unit. (Gentry [Biology]) Bio 470. Ethology Bio 502. General Physiology Advanced course dealing with selected in-depth topics: See Department of Physiology and Biophysics. social organization and social ecology; behavior genetics; Bio 5031. Endocrine Physiology and Pharmacology evolution; human behavior and development; neural and A lecture course consisting of both faculty and student endocrine models. A Gestalt approach to the intrinsic presentations for in-depth coverage of selected areas of complexities of organism-environment interaction will be endocrinology, including neuroendocrinology, reproduc- made. Credit 3 units. (Staff [Psychology]) tion, steroids, and metabolic fuel regulation. Bio 471. Phytogeography (J. Martin [Pharmacology]) An introduction to the current and past geographical distributions of plants, emphasizing ecological, geological Bio 504. Environmental Pathology and historical factors. Credit 3 units. (Gentry [Biology]) Lectures and seminars discussing the effect of modern Bio 481. Ecology and the Environment industrial environment on man's health. The adaptability Possible topics include: the N-cycle and the use of of man, his ability to manipulate his environment and the fertilizer N, pests, pesticides and pest control; the Green effects of these manipulations in regard to health and Revolution, its advocates and its technical and social disease will be discussed. Topics include acute and chronic critics; Malthus and the Neo-Malthusians; the demo- diseases associated with air and water pollution, waste graphic transition, social and economic influences on disposal, pesticide usage, transportation, radiation, and population growth rates. Prerequisite, Bio 381 or consent noise. Credit 2 units. (Kuhn [Pathology], of instructor. Credit 2 or 3 units. (Kohl [Biology]) Schmidt, Staff) Bio 482. Ecology: Ecosystems Bio 5051. Foundations in Immunology I A study of selected topics including measurements of An in-depth introduction to immunology for graduate species diversity, productivity, carbon cycle, energy flow students. Topics include: antibody structure and genetics, and secondary succession with emphasis on trophic cellular immunology, complement, transplantation im- dynamics of specific interactions such as predation and munology, and clinical immunology. Credit 3 units. grazing. Credit 3 units. (Covich [Biology]) (Kapp [Pathology and Microbiology/Immunology])

115 Bio 506. Microscopic Anatomy mission, and scanning electron microscopy); other tech- Sec Department of Anatomy and Neurobiology. niques (bio-and immunoassay, various physiologic corre- Bio 507, 508. Pharmacology lates). Design of experiments using laboratory animals See Department of Pharmacology. and autopsy specimens will be emphasized. Students will be expected to do a short research project of interest to Bio 509, 510. Current Topics in Pharmacology them. Limited enrollment by permission of instructors. Topics of current interest will be presented and dis- Graduate students should have had at least one course in cussed. Critical evaluation will be made of recent articles histology and also preferably a course in pathology. Two in the scientific literature. Required of all graduate stu- class hours per week. Credit 2 units. dents in the department. Credit 2 units for the year. (Hartroft, Greider [Pathology]) (Russell [Pharmacology], Staff) Bio 521. Cellular Aspects of the Immune Response Bio 511. Intracellular Transport of Macromolecules The mechanisms of regulation of immune responses by A discussion of the organelles responsible for the antigen, macrophages, T cells, B cells, and their products movement of macromolecules in cells. Endoplasmic will be discussed. The material covered will vary in rcticulum, the Golgi apparatus, secretory vesicles, plasma emphasis from year to year and will stress critical analysis membrane, lysosomes. Part of the course will use the of the literature. Credit 2 units. (Pierce [Pathology]) seminar format. Credit 2 units. (Stahl [Physiology and Biophysics]) Bio 522. Immunogenetics Offered in spring semester only. Lectures on selected Bio 512. Selected Topics in Developmental Biology examples of application of immunologic techniques to A lecture-seminar course devoted to an in-depth analy- detection of genetic variations in macromolecules (blood sis of a restricted number of topics of major current groups, allotypes, lymphocyte antigens), genetic dissec- interest in developmental biology. A series of guest lec- tion of immune mechanisms (immune response genes tures whose research is at the forefront of the area of immunodeficiences), and genetics and immunology of interest will be invited to the campus to discuss their transplantation and of neoplasia. Prerequisite, consent of research activities with the class. These guest lectures will instructor. 2 class hours per week. Credit 2 units. be supplemented by extensive readings from the current (Shreffler [Genetics]) literature, lectures by local faculty and informal discussions. Students will be evaluated on the basis of one or two research proposals they will prepare during the l semester. Credit 2 units. (Kirk [Biology]) [ Bio 5141. Advanced Cell Biology loi advanced students in the area ol cell biology anil related fields. Lectures stress recent advances in the field of eukaryotic cell biology. Emphasis on membranes, membranous organelles, and cell motility systems. Pre- requisite, Bio 451 and Bio 334 or consent of instructor. 3 class hours a week. Credit 3 units. (Goodenough [Biology], Heuser [Physiology/ Biophysics]) Bio 515, 516. General Pathology See Department of Pathology. Bio 517. Introduction to Immunology A short introduction to Humoral and Cellular Immun- ity lor nonspecialists. Students intending to take more advanced courses in Immunology oi who are preparing for preliminary examinations in Immunology should take Bio 5051. Credit 2 units. (Davie [Microbiology and Immunology]) Bio 518, 519. Pathology Research Seminar Graduate students. MS IT students, postdoctoral trainees, and pathology faculty present discussions of current research from the literature, or when appropriate, from their own laboratories. Priority for presentation is given to graduate and MS I P students. 1 hose wishing to obtain credit may do so (2 units year). One hour per week. (Baen/iger [Pathology], Staff) Bio 520. Methods in Experimental Pathology- Discussions and demonstration of routine and special d microscopic techniques (light, phase, fluorescent, trans- no [ Bio 523. Microbial Physiology and Genetics Molecular and cellular aspects of microbial growth and reproduction. Lectures and laboratory in the first nine weeks of the fall semester. Credit I unit. (D. Schlessinger [Microbiology and Immunology]) Bio 524. Radiation Biology The action of ionizing radiation at the biochemical, cellular, tissue, and whole organism levels will be discussed. A cellular approach will be taken for a number of topics such as the target for lethality, the biological basis of radiation therapy, and radiation effects on specific tissues in mammals. Credit 2 units. (Sapareto [Cancer Biology]) Bio 525. Fundamental Concepts in Cell Membrane Physiology and Biophysics A lecture course devoted to theoretical principles underlying the physiological properties of biological membranes. Topics to be covered include (1) electrolyte solution properties including interface potentials, (2) diffusion, osmosis, and transport through pores, (3) electro- diffusion and membrane potentials, (4) selectivity and kinetics of transport through ion channels, and (5) kinetics and thermodynamics of carrier-mediated transport. Credit 3 units. (De Weer [Physiology and Biophysics], Rakowski and Reuss) Bio 526. Selected Topics in the Physiology and Biophysics of instructor, since enrollment is limited by computer of Cell Membranes availability. Two class hours a week. Credit 2 units. ln-depth analysis of selected readings. Topics include: (Holmes [Biochemistry]) movements of salt and water across cell membranes and epithelia; ion channels in biological and artificial mem- Bio 531. Advanced Biochemistry branes; kinetics of carrier mechanisms; and the chemistry See Department of Biological Chemistry. and kinetics of the sodium pump. Credit 3 units. Bio 532. Biochemistry of the Extracellular Matrix (De Weer [Physiology and Biophysics], An in-depth survey of the chemistry and metabolism of Rakowski and Reuss) the principal components of the extracellular matrix, Bio 528. Cell Development in Animals and in Culture principally collagen, elastin and the glycosamino glycans. Lectures and student seminars on the fate of individual Chemical and physical properties of these molecules will cell types in animals and in cell culture. Principles of cell be discussed, as well as aspects of their biosynthesis and renewal exemplified by muscle, liver, and kidney regener- degradation. Emphasis will be placed on the relationships ation. General cell culture, including growth factors, between structural features and metabolic events involv- hormonal factors, cyclic nucleotide effects, and genetics ing these complex molecules and their physiologic func- of cultured cells. The fate of normal cells will be discussed tion: the maintenance of the stable three-dimensional along with the relation of differentiation to cell division, architecture of animal tissues. Credit 2 units. the role of cell-cell interactions, mechanisms of carcino- (Jeffrey [Biochemistry]) genesis, and studies of teratomas. Prerequisite, Bio 451 and permission of instructor. Three class hours a week. Bio 533. Pathogenic Microbiology Credit 3 units. (D. Schlessinger A survey of the major genera of pathogenic bacteria, [Microbiology and Immunology], Lieberman) fungi and parasites. Lectures and laboratory in the second Bio 529. Animal Virology nine weeks of the fall semester. Credit 2 units. A general introduction to animal and human viruses. (Staff [Microbiology and Immunology]) Lectures in the second nine weeks of the fall semester. Bio 536. Physical Chemistry of Macromolecules Credit 1 unit. (Perrault [Microbiology Application of physical chemistry to the study of pro- and Immunology]) teins, nucleic acids and other natural and synthetic poly- Bio 530. Laboratory Computer Workshop mers. The thermodynamics of macromolecular solutions A laboratory course supplemented by reading and and the principles behind osmotic pressure, light scatter- occasional lectures. An interactive time-sharing computer ing, viscosity, ultracentrifugation, diffusion, and electro- programmed in PASCAL will be used to solve a series of phoresis experiments. Offered in alternate years. Prereq- problems, including collection and processing of data, uisites, two semesters of Physical Chemistry or permis- representation of information in data files, and presenta- sion of instructor. Credit 3 units. Identical with Chemistry tion of output in graphic form. Prerequisite, permission 577. (Holtzer [Chemistry])

117 Bio 537. Protein Chemistry and Enzyme Mechanisms Bio 5441. Mechanisms of Neoplasia Protein chemistry; primary and three-dimensional The first part of the course provides a basic back- structure; en/yme mechanism; development of enzyme ground in neoplasia in man and animals as a framework kinetic theory, including concepts of regulatory enzymes. for the application of concepts in cell and molecular Credit 3 units. (Grant [Biochemistry]) biology to neoplasia. The major part of the course will be devoted to analyzing the role of chemical, physical, and Bio 538. Structure and Function of Cell Membranes viral carcinogens in the induction of cancer, promoters, and Surfaces the role of mutation and gene expression in neoplasia, Topics include contemporary cell membrane models; changes in the cell surface and metastasis. Credit 2 units. membrane structure as revealed by electron microscopy. X-ray analysis, etc.; physical properties of lipids and Minimum of ten students. membrane proteins; model membranes and their applica- (Lieberman [Pathology], D. Schlessinger, Staff) tions; permeability and active transport in mammalian Bio 5451. Introductory Biophysical Chemistry and bacterial systems; cell recognition, contact inhibition, Applications of physical chemistry to biochemical and transformation; immunological characteristics of problems at an introductory level. There will be three membranes. Credit 3 units. sections: multiple equilibria, spectroscopy, and kinetics, (1 i.i/ni K Km nfeld ! Biochemistry |) each comprising about one third of the course. One sec- Bio 539. Topics in Animal Virology tion may be taken individually for one credit. Permission I he course will consist of readings and seminars in of instructor. Three class hours per week. Credit 3 units. specific areas of animal virology. The topics will vary (Elson [Biochemistry]) from year to year. Credit 2 units. Bio 546. Antibodies: Structure, Function, and Formation (S. Schlesingei [Microbiology and Immunology]) The principal features will be examined in lectures, Bio 540. Cell Surface Receptors assigned reading of current research papers, and in stu- Course will consist of discussion of cell surfacecompo- dent seminar presentations. Emphasis will be placed on nents which allow cells to interact specifically with a the genetic and molecular events which govern the variety of environmental substances such as drugs, neuro- appearance of antibodies during the immune response. transmitters, protein hormones, toxins and other cells. Offered in alternate years. Credit 2 units. I Ins course will include a consideration ol cell cell inter- (Fleischman [Microbiology and Immunology]) actions, maeromolecule receptors and small molecule Bio 548. Nucleic Acids and Protein Biosynthesis receptors. Credit 3 units. Fundamental aspects of the structure, biosynthesis, (Needleman [Pharmacology], Bradshaw, Frazier) and function of nucleic acids and the biosynthesis of Bio 541. Molecular Biology of Prokaryotes proteins in eukaryotes and their viruses. Emphasis on About 15 hours of lecture followed by seminar presen- mechanisms involved in the biosynthetic processes and tations on selected topics by each student. Growth, the regulation thereof. Prerequisite, Bio 451 and 453 or metabolism and genetics of the bacterial cell including equivalent, or consent of instructor. Three class hours a transport mechanisms, the regulation of gene expression week. Credit 3 units. and protein synthesis and the molecular biology of virus (Olson [Genetics], Boime [Pharmacology]) infection by virulent and temperate bacteriophages. Clas- Bio 550. Medical Genetics sical and more recently developed experimental tools, Lectures and clinical conferences on human and medi- such as genetic engineering, as well as the conceptual cal genetics that include population and quantitative bases for present know ledge, will be emphasized. Credit 2 genetics, clinical cytogenetics, biochemical genetics and units. (Kennell [Microbiology and Immunology]) metabolic defects, counseling, and immunogenetics. Lec- Bio 5422. Topics in Gene Expression tures and clinical conferences only. Credit 2 units. Pre- A weekly journal club discussing articles of current requisite, an introductory genetics course or consent of interest in the field ot gene expression. Prerequisite, grad- instructor. (Levine [Genetics]) uate status. One hour seminar per week. Credit one unit, Bio 551, 552. Topics in Neurobiology contingent on one presentation per semester. A weekly seminar series on selected topics of current (Chirgwin [Anatomy], Waterston, Olson) interest in neurobiology, such as synaptic and neuromuscular transmission, plasticity in the nervous system, the Bio 5431. Computer Modeling of Physiological structure and function of receptors, etc., 9 a.m., Satur- Systems days. 928 McDonnell. Open to graduate and medical The fundamentals of interactive computing and its students. No credit. (Staff [Anatomy and Neurobiology, application to the numerical modeling of physiological Physiology and Biophysics and Pharmacology]) systems. The illustration using models developed by the Bio 553. Seminar in Cellular Basis of Behavior faculty for use in teaching. Some "hands-on" computer Motor control in annelids, molluscs, arthropods and projects Prerequisite, some familiarity with computing vertebrates. Neural mechanisms responsible for the con- (TOR IRAN or BASIC) or consent of instructor. 3 class trol of movement will be emphasized in student presenta- hours per week. Credit 3 units. (Barry [Physiology]) tion of original papers. Prerequisite. Bio 3421 or Bio 554

us r L

and permission of instructor. Two class hours a week. Discussion of cardiovascular regulation, respiratory path- L Credit 2 units. (Stein [Biology]) ways, the role of the hypothalamus and limbic system in Bio 554. Neural Sciences visceral and neuroendocrine functions. Prerequisite, Bio See Departments of Anatomy and Neurobiology and 554 or consent of instructor. 2 class hours a week. Credit 2 Physiology and Biophysics. units. Identical with Psychology 558. (Loewy [Anatomy/Neurobiology] Staff) Bio 555. Neuropharmacology Basic and intermediate neuropharmacology for gradu- Bio 566. Sensory Receptors ate and medical students. The course covers the principles Advanced seminar course on structure and function of and details of neurotransmission in nervous tissue and visual, auditory, vestibular, cutaneous and muscle recep- I mechanisms of action of neurotropic drugs. Credit 3 tors. Credit 2 units. (Hunt [Physiology]) units. (Ferrendelli [Pharmacology], Staff) Bio 572. Seminar in Plant Biology: Plant Biochemistry Bio 559. Nerve, Muscle, and Synapse Discussion of current research and concepts of mor- The ionic basis of the resting and action potentials and phogenesis, growth, and development. Credit 2 units. the mechanisms of synaptic transmission. Students will (Varner [Biology]) be expected to present two to five one-hour seminars Bio 574. Systematics and Ecology of Monocotyledoneae based on assigned original papers. Credit 2 units. The course will survey all monocotyledonous groups of (Rovainen [Physiology and Biophysics]) plants with systematic emphasis given to the familial level. Bio 561. Topics in Molecular Neurobiology A review of modern evolutionary theories for the class The course will consist of lectures and seminars on Monocotyledoneae will be presented. The course outline selected areas in which the function of the nervous system will follow the system of Cronquist. Particular emphasis is being studied at the molecular level. Among topics will be given to the families Cyperaceae, Gramineae, considered will be: behavior in simple organisms, contin- Bromeliaceae, Zingiberaceae, Marantaceae, Palmae, uous neuronal lines, intraxonal transport, transmitter Cyclanthaceae, Araceae, Liliaceae and Iridaceae, for receptors, transmitter biosynthesis, cell recognition, fila- which instructors have a special interest. The morphology mentous proteins of the nervous system. Credit 2 units. systematics and ecology of each family will be discussed, (Willard [Anatomy and Neurobiology], D. Gottlieb) with special emphasis given to their phenological behavior, pollination and fruit dispersal biology when sufficient Bio 562. Neural Control of Posture and Movement information is available. Credit 2 units. Advanced seminar course. Part 1—Sensory and motor (Croat [Biology]) innervation of muscle. Spinal reflex organization. Part II—Supraspinal control. Cerebral cortex, cerebellum, Bio 575. Advanced Studies in Plant Systematics basal ganglia, brain stem. Offered odd-numbered years. Seminars in specific topics includinganatomy, chemo- Credit 2 units. taxonomy, cytology, ecotaxonomy, embryology, Part /—(Hunt [Physiology nomenclature, palynology, phytogeography and biblio- and Biophysics]) graphy. Prerequisite, Bio 322 or 376. One seminar a week. Part II—(Thach [Anatomy Credit 1 unit a semester. (Staff [Biology]) and Neurobiology]) Bio 580. Seminar in Population Biology: Evolution Bio 563, 564. Techniques in Neural Sciences This weekly seminar, covering topics in both popula- A laboratory course for first-year graduate students in tion genetics and ecology, will be taken by graduate stu- the Neural Sciences Program. Including practical expe- dents in this program each semester. Research and litera- riences in: intracellular recordings from nerve cells and ture reports will be given by staff, visitors and graduate muscle fibers; growth of nerve tissue culture and electron students. Credit 2 or 3 units. (Staff [Biology]) microscopy of it; recording of synaptic potentials; extra- Bio 581. Seminar in Techniques in Field Biology cellular recording in mammalian peripheral and central Planning and presentation of techniques in selected nervous system; tracing of CNS pathways by autoradio- areas of population biology. Coordinated with Bio 484. graphic and histochemical techniques; and biochemical Prerequisite, consent of instructor. Credit 3 units analysis of axonal transport. (Staff [Biology]) (Woolsey [Anatomy and Neurobiology], Staff [Physiology Bio 590. Research and Biophysics], [Biology], Credit to be arranged. (Staff) [Pharmacology]) Bio 565. Central Regulation of Autonomic and Visceral Systems For neural science students, introduction to the central Note—The number preceding the course title indicates that the control of the autonomic nervous system and the neural course carries credit in the Graduate School of Arts and basis of various visceral functions (eating and drinking). Sciences.

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PROGRAM IN BIOMEDICAL Associate Professors Assistant Professor ENGINEERING R. Martin Arthur Stuart Boxerman I Richard E. Clark This course of graduate study is designed to provide Richard A. Gardner Senior Research Associate education and training lor students wishing to apply William F. Holmes Norbert S. Mason principles of modern engineering and mathematics to Marcus E. Raichle theoretical and practical problems in biology and medi- Lewis J. Thomas, Jr. Research Associate I cine. Students and faculty of both the School of Engineer- George I. Zahalak Kenneth B. Larson ing and Applied Science and the School of Medicine participate in the program. Biomedical Engineering course offerings: Every student seeking an advanced degree in engi- Bio 458. Biophysics of the Ear L: neering must be admitted to one of the participating EE 481. Foundations of Bioengineering departments of the Sever Institute of Technology, the graduate division of the School of Engineering and BMed 502. Mathematical Methods in Biophysics Applied Science. The program permits the student to HMHI 547. Biological Mass and Momentum Transfer earn a certificate in biomedical engineering in addition to BMed 560. Biomechanics the M.S. or D.Sc. degree in a chosen engineering field. BMed 576. Sensory Communications Students not candidates for a degree are welcome to take courses as electives. BMed 581. Principles of Clinical Engineering Graduate study plans are tailored to the individual's BMed 582. Biophysical Measurement needs and interests, and provide essential background in BMed 600. Research for Doctoral Dissertation the related areas of life and medical sciences. Students BMed 651. Science of Synthetic and Biological with diverse undergraduate backgrounds may be admit- Polymers ted provided they have adequate preparation and experience in mathematics and the physical sciences. Areas of BMed 660. Biomedical Applications of Small Digital Computers specialization include sensory communications, electrocardiography. How and diffusion in biological systems, BMed 682. Technology in Health Care electrobiology, technology in health care, biomedical BMed 693. Special Topics in Biomedical Engineering statistics, modeling of biological systems, engineering of BMed 694. Special Topics in Clinical Engineering artificial organs, drug concentration control, urody- BMed 695. Clinical Engineering Internship namics, and applications of advanced computer techniques to biology and medicine. Research facilities avail- For additional related courses, see Biomedical Com- able to the program are located in the School of Engineer- puter Laboratory in this Bulletin and the Bulletin of the ing and Applied Science, the School of Medicine, and the School of Engineering and Applied Science. Washington University Computer Laboratories. The faculty includes representatives from the Biomedical Computer laboratory, the Departments of Biological Chemistry, Physiology and Biophysics, Preventive Medi- cine and Public Health, Radiology, Surgery, and Anat- omy and Neurobiology in the School of Medicine; and the Departments of Computer Science, Chemical, Civil, Electrical, and Mechanical Engineering, and Systems Science and Mathematics in the School of Engineering and Applied Science. Complete course listings and information about application and degree requirements may be found in the Bulletin of the School of Engineering and Applied Science, I Professor and C hairman John I.. Kardos t'xecutivr ( ommittee Charles E. Molnar Harold W. Shipton William F. Pickard Salvatore P. Sutera i Michel M. Ter-Pogossian Professors Curt Thies Saul Bovarsky Donald F. VV'ann Jerome R. Cox, Jr. Reimut Wette

121 Curriculum and Sequence of Study Allied Health Required courses constitute 50 percent of the course sequence for the master of health administration degree, offering vital exposure to the generic knowledge in the Professions health administration and planning area. In addition to the elective courses available within the Health Adminis- Programs are conducted by the School of Medicine tration and Planning Program (HAP), students may take in health administration, occupational therapy, physical up to 15 semester hours of graduate work in other units of therapy, radiologic technology, and pediatric nursing Washington University. The HAP student's faculty practice. All courses are approved by the American Medi- adviser must approve the selection of courses in the stu- cal Association or other certifying agencies, and gradu- dent's individual curriculum. The student's previous aca- ates qualify for certifying examinations. For further demic work, employment experience, and ultimate per- information, write to the director or educational director formance goals enter into the individual's personalized listed under the particular program, 660 South Euclid curriculum. Avenue, St. Louis, Missouri 63110. As a means of furthering interdisciplinary study, up to fifteen semester hours of HAP courses are open to interested graduate students from other areas of HEALTH ADMINISTRATION AND Washington University. There is also a joint M.H.A.-J.D. PLANNING PROGRAM degree between the Health Administration and Planning The Philosophy Program and the School of Law. In addition, there arc The faculty of the Health Administration Planning joint degrees that are under development between the Program of Washington University believes that adminis- Health Administration and Planning Program and the trative personnel in health organizations require not only graduate schools of Business Administration, the George a solid foundation in management but also in understand- Warren Brown School of Social Work and the School of ing of those aspects of finance, regulation, and planning Architecture. unique to the health care field. Additionally, since its The sequence of study requires two years, each con- inception in 1946, the program has acted on the premise sisting of a fall and spring semester. Upon completion of that health administration students would benefit from the four semesters, or a total of 60 units which includes the exposure to the environment in which they will ultimately required thesis, the student will receive a master of health be involved. To this end the program has maintained an administration (M.H.A.) degree conferred by Washing- organizational structure consisting of a core faculty ton University. The statute of limitations is five years from located within the School of Medicine, augmented by the date of matriculation to complete all requirements for faculty from other schools and departments within the the M.H.A. degree. Contingent upon graduation the stu- University, as well as affiliated institutions and agencies. dent has the option of pursuing a 12-month postgraduate This multidisciplinary approach enables the student to administrative residency. A certificate will be awarded by acquire not only specific management skills but an under- Washington University School of Medicine and the affil- standing of the many complexities unique to the health iated residency organization upon completion of the care sector. residency.

121 L. L i Administrative Residency tor and resident. HAP also sponsors an annual precep- The 12-month optional postgraduate administrative tors conference at Washington University. Interaction of L residency will be served in a hospital, health agency, or these site and campus visits enables joint review of the health organization which has been recommended and resident's progress, as well as evaluation and refinement approved by the full-time faculty. This option is available of the administrative residency experience. only to those persons who have the M.H.A. degree con- Admission Requirements L: ferred upon them by Washington University. The purpose Washington University's Health Administration and of the residency is to provide the graduate with an oppor- Planning Program is committed to nondiscriminatory [ tunity to observe and practice those concepts and princi- practices in selection of applicants regarding race, sex, ples learned during the didactic on-campus exposure. The age, religion, or national origin. The faculty and staff are administrative residency is strongly recommended, as this affirmatively committed to recruiting, enrolling, and edu- postgraduate clinical exposure is deemed necessary for cating students from minority groups who have the adequate professional career preparation. The residency potential for graduate study. is completed under the direction of a well-qualified and A minimum of a bachelor's degree from an accred- experienced hospital administrator who is given an ited university or college acceptable to Washington Uni- annual adjunct faculty appointment at Washington Uni- versity School of Medicine is required, as is completion of versity School of Medicine. the Graduate Record Examination (Aptitude Test), the The full-time faculty maintains close liaison with the Miller Analogies Test or the Graduate Management administrative resident and the preceptor. An educa- Aptitude Test. No specific undergraduate major field of tional plan which outlines the resident's activities for the study is required for admission into the program; how- coming year must be filed by the preceptor. The preceptor ever, introductory courses in accounting, economics, sta- also sends two evaluation reports to the Director of HAP tistics (or their equivalents), and mathematics through and shares the responsibility for recommending awarding college algebra are very strongly recommended. of the certificate by Washington University School of Tuition per semester $ 3,125 Medicine and the residency site organization. (Four semesters .. 12,500) Within available resources an on-campus faculty Books and supplies (per semester) 280 member visits the residency site to meet with the precep- Application fee (nonrefundable) 20

Associate Professor and Director Assistant Professors Assistant Professors (Adjunct) James O. Hepner, B.A., University of Stuart B. Boxerman (Biostatistics), Donald W. Cordes, A.B., Hope Iowa, 1955; M.H.A., Washington B.S.E.E., Washington University, 1963; College, 1940; M.A., University of University, 1959; Ph.D.. University of M.S.E.E., 1965; D.Sc., 1970. (See Michigan, 1941. Iowa, 1964. Department of Preventive Medicine and Robert E. Frank, B.S., St. Louis Associate Professor and Public Health.) University, 1950; M.A., 1962. Deputy Director Mary Jane Budenstein, B.A., University Frank S. Groner, A.B., Baylor Donald J. Horsh, B.S.B.A., University of Montevallo, 1973; M.A., Washington University, 1934; LL.D., East Texas of Nebraska, 1941; M.H.A., Washington University, 1975; Ph.D., 1977. Baptist College, 1946. University, 1951; J.D., St. Louis Roy C. House, A.B., Evansville College, University, 1953. Bernard Feigenbaum (Health Care Research), B.A., University of 1939; M.S.H.A., Northwestern Professor California, Los Angeles, 1974; M.A., University, 1949; H.S.D., Southwestern David A. Gee, B.A., DePauw 1976. (See Department of Preventive College, 1978. University. 1949; M.H.A., Washington Medicine and Public Health.) Rita E. Numerof, B.A., Syracuse University, 1951. University, 1969; M.S.S., Bryn Mawr, Ronald E. Gribbins, B.A., St. Norbert 1971; Ph.D., 1979. Associate Professors (Adjunct) College, 1966; M.B.A., University of Ted Bowen, B.S., Austin College, 1941; Wisconsin, 1971; Ph.D., 1975. Boone Powell, LL.D., Baylor M.H.A., Washington University, 1948. University, 1958. Virginia D. Hennelly, B.S., Maryville Sister Mary R. Rocklage, B.S., St. James A. Canedy, B.A.. Hastings College, 1966; M.H.A., Washington Xavier College, 1961; M.H.A., St. Louis College, 1950; M.H.A., Washington University, 1971; Ph.D., 1977. University, 1952. University, 1963. James D. Harvey, B.A., University of Robert J. Hickok, B.S., Washington Robert F. Scates, B.A., Baylor South Dakota, 1950; M.H.A., University, 1953; M.H.A., 1971. (See University, 1939. Administration and Program in Washington University. 1952. Glenn N. Scott, B.A., Oklahoma Baptist Physical Therapy.) David H. Hitt, B.S., University of University, 1956; M.H.A., Washington Alabama, 1949; M.Sc., 1950; M.H.A., Robert S. Woodward (Health Care University, 1962. University of Minnesota, 1952. Research), B.A., Haverford College, Marc D. Smith, B.S., University of Linn B. Perkins, A.B., Amherst College, 1965; Ph.D., Washington University, Missouri, 1971; M.Div., Concordia 1949; M.H.A., Washington 1972. (See Department of Preventive (Seminex), 1975; Ph.D., St. Louis University, 1951. Medicine and Public Health.) University, 1979.

122 L.

Gail L. Warden, A.B., Dartmouth Fredrick J. Graves, B.S., Southern Elwood P. Opstad, B.S., State College, I960; M.H.A., University of Illinois University, 1961; M.B.A., George University of Iowa, 1947; M.H.A., Michigan, 1962. Washington University, 1965. Washington University, 1949. Instructors (Adjunct) H. Richard Grisham, B.S., University of Joseph H. Powell, B.A., University of Miner L. Brown, B.A., St. Lawrence Oklahoma, 1968; M.H.A., Washington Tennessee, 1950; M.H.A., University of University, 1962; M.H.A., Washington University, 1974. Minnesota, 1955. University, 1965. Howard L. Hays, B.S., University of Wynn E. Presson, B.B.A., University of Richard W. Brown, B.A., Phillips Omaha, 1957; M.H.A., Washington Texas, 1963; M.H.A., Washington University, 1968; M.H.A., Washington University, 1959. University, 1965. University, 1970. William B. Hope, Jr., B.S., University of J. Larry Read, B.S., Lamar University, L. Gerald Bryant, B.B.A., University of Tennessee, 1960; M.S., 1962; M.P.H., 1968; M.H.A., Washington Oklahoma, 1964; M.H.A., Washington Johns Hopkins University, 1968; University, 1974. University, 1968. Sc.D., 1971. James C. Ruthrauff, B.S.B.A., Sarah G. Burtram, B.A., Dominican Duane T. Houtz, B.A., University of University of Kansas, 1957; M.S., L College, 1970; M.H.A., Washington Kansas, 1955; M.H.A., Washington Northwestern University, 1959. University, 1972. University, 1960. Charles B. Stearns, B.S., Northwestern Howard M. Chase, B.S., Lewis and Mabel P. Howell, B.Ed., Southern University, 1960; M.H.A., Washington Clark College, 1959; M.H.A.. University Illinois University, 1941; M.H.A., University, 1962. L of Minnesota, 1966. Washington University, 1966. James D. Stewart, B.A., Brigham Arthurline Clingman, B.S., University of James B. Humphreys, B.S., Westminster Young University, I960; M.H.A., Houston, 1957; M.H.A., Washington College, 1963; M.H.A., Trinity Washington University, 1975. University, 1959. University, 1969. Richard C. Suchenski, B.S., Fordham L Paul F. Detrick, B.A., Kansas State Edgar O. Mansfield, B.S., Northwestern University, 1953; M.H.A., Virginia Teachers College, 1949; M.H.A., University, 1950; M.H.A., 1952; Commonwealth University, 1961. Northwestern University, 1951. Dr.P.H., Ohio Northern James H. Sullivan, B.A., Michigan Carl J. Felling, B.A., Westminster University, 1956. State University, 1950; M.H.A., College, 1964; M.B.A., George Larry L. Mathis, B.S., Kansas State University of Michigan, 1957. Washington University, 1967. College, 1965; M.H.A., Washington Charles E. Thoele, B.Sc, St. Louis Robert D. Finney, B.S., University of University, 1972. University, 1953; B.S., 1961; M.B.A., Utah, 1962; M.A., 1965; Ph.D., 1969; Beverly B. Monica], B.S., Washington Southern Illinois University, 1976. M.S.W., Washington University, 1971. University, 1960; M.H.A., 1972. John Warmbrodt, B.S., St. Louis Thomas W. Fourqurean, B.B.A., Texas John P. Nobel, B.S., Florida A & M University, 1939. College of Arts and Industries, 1939; University, 1959; M.H.A., Columbia Paul H. Wunderlich, B.A., Valparaiso M.B.A., University of Chicago. 1949. University, 1962. University, 1962; M.H.A., Washington Phillip H. Goodwin, B.A., Hendrix Robert J. O'Brien, B.S., Phillips University, 1967. L College, 1943; M.H.A., Washington University, 1960; M.H.A., Washington University, 1968. University, 1965. Lecturers Harold Hinderer, B.A., College of St. Thomas, 1952. L Merlin E. Lickhalter, B.A., .it-., Massachusetts Institute of tit. Technology, 1957. 7 - 1 : l: Harry E. Panhorst, B.S., University of Missouri, 1938; M.H.A., Washington m University, 1949. Lecturers (Adjunct) Jerry Garrett, B.S.B.A., University of L Missouri, 1964; M.A., Webster College, 1979. Terry L. Nimnicht, B.S., University of Scranton, 1976; M.H.A., George Washington University, 1979. Henry Mandro, B.S., Temple University, 1960. Kenneth W. Peters, B.A., Luther College, 1950; M.H.A., Baylor University, 1958. Colin C. Rome, Jr., B.A., Beloit College, 1964; M.A., University of Iowa, 1966; Ph.D., 1968.

123 PROGRAM IN PHYSICAL THERAPY The program provides an environment in which The program of instruction leading to the Bachelor students, faculty, and physical therapy practitioners are £ of Science degree in physical therapy is an intensive two- guided in the acquisition of the requisite body of knowl- year curriculum offered at the School of Medicine. Appli- edge for the current and future practice of physcial [ J cants for admission must have completed 60 hours at an therapy. The program strives to bring scholarly knowl- accredited college or university. Requirements are spe- edge to bear on the problems of the profession through cific courses in English, psychology, biology, physics, research activities of the faculty. By providing an envir- chemistry, mathematics, and social sciences. onment which permits expression of the individual's Kinesiology and pathokinesiology form the core of imagination and creativity, the program encourages the the curriculum. Kinesiology/pathokinesiology is the professional growth of its constituents. integrative study and application of physical, biological, Tuition per semester $3,563 and applied science principles to normal and abnormal Tuition for internship (estimate) 100 human movement. The basic and clinical sciences of Further information may be secured by direct cor- kinesiology and pathokinesiology provide the foundation respondence with the Program in Physical Therapy, upon which the physical therapist can develop and apply Campus Box 8083, 660 South Euclid Avenue, St. Louis, scientific principles to patient care. The goal of the curric- Missouri 63110. ulum is to produce practitioners who can competently utilize the scientific approach to assess, remediate, and prevent pathokinesiological disorders.

Associate Professor Emeritus Beatrice F. Schulz, B.S., Washington University, 1949; M.A.. 1955. Assistant Professor Emeritus Lorraine F. Lake, B.S., Washington University, 1950; M.A., 1954; Ph.D., 1962. Associate Professor and Director Steven J. Rose, B.S., Ithaca College, 1962; Ph.D., Albert Einstein College of Medicine, 1977. Visiting Associate Professor Eugene Michcls, B.S., University of Cincinnati, 1950; Certificate in P.T., University of Pennsylvania. 1951: M.A. University of Pennsylvania, 1967. Assistant Professors Robert J. Hickok, B.S.. Washington University, 1953; M.H.A., 1971. (See Administration and Health Administration and Planning Program.) Shirley A. Sahrmann, B.S., Washington University. 1958; M.A., 1971: Ph.D., 1973. (See Departments of Neurology and Neurological Surgery and Physiology and Biophysics.) Instructors M. Susan Beamer, B.S.. Indiana University. 1969: M.A., Washington University. 1977. Donald M. Bitz, B.S., University of Illinois. 1973; M.D.. Washington University School of Medicine. 1977. Robert H. Deusinger, B.S., Slippery Rock State College. 1967; M.S.. University of Massachusetts. 1968; Ph.D.. The University of Iowa. 1981.

124 Susan Deusinger, B.S.. University of Elvera C. Guebert Research Assistants Kansas, 1968: M.A., Washington Barbara Hayes Ronna S. Kaiser, B.S., State University University, 1980. Betty Helfrien of New York at Buffalo, 1979. Sven G. Eliasson, Swedish Medicine Judy Hembree Thomas P. Mayhew, B.S., State (Candidate, Royal Caroline University of Diedra Henneke University of New York at Lund, Sweden, 1954; (Ph.D.), University Jeanette Hinrichsen Buffalo, 1979. of Lund, Sweden, 1952. Pamela Hoffman Helen Marie Holzum Peter Miller, B.S.. New York University, Judith Mange, B.S., Washington 1980. University, 1968; M.B.A., University of Major Norris Jesse Kathleen M. Keller Julie M. McClure, B.A., Brown Missouri; St. Louis. 1980. Carol Knudson University. 1975. Barbara J. Norton, B.S., Washington Gerald Kraft University, 1966. Lecturers Joanne Ladd Catherine C. Brodzinski, B.S., Richard F. Roettger, B.S., Washington Sandra Lake St. Louis University. 1974. University, 1962. Nick Laubcnthal Jules M. Rothstein, B.S., New York Mary Liedloff Suzanne M. Cornbleet, B.S., University University, 1975; M.A., 1979. Judy Ligman of Colorado, 1975. Debra L. Strobach, B.S., University of Janet Lindsten Anthony Delitto, B.S.. State University Missouri. 1973: M.A., University of June Macchiavema of New York at Buffalo, 1979. North Carolina, 1975. Joann Markell Janet L. Gourley, B.S.. University of Kathy Markensen Missouri, 1977. Instructors (Clinical) Sandra Martin Kathleen M. Haralson, B.S., University Elaine Angelo Juanita Mayer of Kansas, 1965. Diane Antonocci Charles Meacci David R. Sinacore, B.S., B.A., State Jolene Apprill Kyle Meyer University of New York at Buffalo, 1979. Susan Burr Sharon L. McNeill Mary Beth Basile Cathie Meglan Barbara Baum Jo Ann R. Niccum Christine O. Bridwell Mary Niemeyer Karen Burns Marilyn Raymond Lawrence F. Chojecki Richard Roettger Debby Davenport Richard Rother Steve Dickoff Erica Rouvalis Bill Dierks Phyllis Rowland Camilla Dude Mary Rudd Patricia M. Ellis Suzanne B. Rutledge Frances L. Erlacker Cindy Rysgaard Gail Fisher Ann Brown Short Charlene M. Flynn Dean Soder Linda Grambow Barbara A. Tschoepe Ellen Jost Sally Wasserman Mark J. Gayer Barbara A. Woodall Ira Gorman Maureen Wulf

125 PROGRAM IN OCCUPATIONAL THERAPY vidual programs of study leading to clinical specializa- The efforts of the Program in Occupational Therapy tion. Occupational therapy students have access to the are directed toward providing students with a thorough extensive resources of the medical school, the patients background in occupational therapy in preparation as and clinics of the University hospitals, and to the practitioners in a rapidly developing field. The primary resources of the Graduate School of Arts and Sciences focus of occupational therapy is the development of adap- located on the Lindell and Skinker campus. Electives tive skills and improved performance, not only in the applicable to area specialization may include courses realm of working for a living but also in tasks and activi- offered throughout Washington University. All students ties concerned with leisure, daily living, and avocations. It are required to submit and defend a research thesis in follows that the occupational therapist must be concerned their area of concentration. with external and environmental barriers as well as bio- Students without professional certification must logical or psychological problems which inhibit occupa- complete basic courses in occupational therapy and bio- tional performance. The therapist must be equally alert to logical sciences before beginning the graduate core-course factors which enhance performance. sequence. These students must also complete six months Within this context of concerns, occupational thera- of clinical internship in preparation for the national certi- pists work with individuals whose abilities to cope with fication examination. These requirements can be fulfilled tasks of living are threatened or impaired by such prob- as part of the master of science degree. lems as the aging process, physical illness or injury, psy- Residency requirements are two academic semesters chological and/or social disability, chronic conditions, of full-time study. Students without professional certifica- poverty and cultural differences, or deficits in perceptual- tion must complete one summer and two additional aca- sensory-motor control or in cognitive, emotional, or demic semesters for residency requirements. social development. Persons with a baccalaureate degree, evidence of a strong academic record, and satisfactory Graduate Undergraduate Program Record Examination scores are encouraged to apply. The curriculum consists of the junior and senior Tuition, per semester $3,562 years of a four-year baccalaureate degree program. Tuition, Summer School, per credit hour 90 Applicants for transfer must present a minimum of 60 Fee, Department, per semester 40 semester hours (including required prerequisites) from an Fee, Department, Summer School 40 accredited college or university. Students wishing to Administrative fee for scheduling clinical internships for enroll at Washington University may enter the program as students without professional certification 300 freshmen. For further information, contact the Graduate Pro- Upon completion of four academic semesters at the gram in Occupational Therapy, 4567 Scott Avenue, St. School of Medicine, the degree of bachelor of science in Louis, Missouri 63110. Phone: (314) 454-2933. occupational therapy is conferred. Six months of supervised clinical internship is required following graduation. Tuition, per semester $3,562 Li^L ' Fee, Department, per semester 40 Fee. Clinical Internship 700 For further information, contact the Office of Admissions, Washington University, Lindelland Skinker HP^^*'* Boulevards, St. Louis, Missouri 63130. Phone: (314) V 889-6000. Graduate Program \ The Graduate Program in Occupational Therapy prepares students to become clinical specialists, researchers or educators in one of the major areas of S current practice: sensorimotor integration, community pediatrics, psychiatry or physical dysfunction. By selec- tively ordering their studies, students may orient their specialization toward service delivery in community, medical or educational settings. All candidates for the master of science degree complete a core program consisting of advanced courses and seminars in occupational therapy theory; clinical, research and teaching practica; research procedures; tests and measurements; and strategies of scientific practice. Students' interests and needs determine the selection of electives to complement core courses and to create indi-

121. I *

Professor and Elias Michael Director Jerry A. Johnson, B.S.. Texas Woman's University, 1953; M.B.A., Harvard University, 1961; Ed.D., Boston University, 1970. Assistant Professor and Associate Director Ellen T. Tyson, B.S., Syracuse University, 1949; M.A., 1950; Cert, in O.T., University of Pennsylvania, 1952. Assistant Professors Erika G. Gisel, B.A., University of Zurich, 1963; B.S.O.T., Temple University, 1972; M.S., 1976; Ph.D., 1979. Ruthan B. Kannegieter, A.B., University of California, 1950; Cert, in O.T., U.S. Army School of Occupational Therapy, 1954; M.A., San Francisco State University, 1958; Ph.D., Stanford University, 1968. Elsie S. Roush, B.S., Madison College, L 1943; M.S., University of Wisconsin, 1947; Ph.D., Washington University, 1950. (See Anatomy and Neurobiology.) Harriet Schmid, B.S., Wayne State University, 1958; M.A., Western Michigan University, 1969; Ph.D., Ohio State University, 1979. Garth D. Tubbs, B.S., Wisconsin State College, 1953; Cert, in O.T., Washington L University 1955. Instructors Susan M. Kusama, B.S.O.T., Washington University, 1965; L M.A., 1978. Mary K. Kuxhaus, B.S.O.T., Washington University, 1973. Carol W. Niman, B.S.O.T., University L of Iowa, 1968; M.S., Spl. Ed., University of Texas at Dallas, 1977. Sandra Kafferty, B.S.O.T., Washington University, 1966; M.A., San Francisco State University, 1975. Mary L. Rath, B.S.O.T., Tufts Instructors (Clinical) University, 1969; M.S., University of Norma Battes Bette Ann Gilbert Margaret Russell Hartford, 1972. Carolyn Baum La Verne W. Grady Barbara Schob Robbie Black Anthony Hollander Susan Schroeder Dixie M. Sleight, B.S., University of L Diana Brower Michelle Isserman Marilyn Wiener Kansas, 1959; M.A.T., Webster Ing-Ing Chiou Jeanne Kloeckner Julia Williams College, 1977. Jeff Cowdry Linda Kopetti Susan Wilson Sallie E. Taylor, B.S.O.T., Richmond Christine Dickmann Sharon Lian Francesca Woods Professional Institute, 1961; M.Ed., Judy Doerr Beverly McClung Lecturer University of Florida, 1964. Paula Dolph Debby O'Mara Joseph C. Kempe, Jr. Diane E. Ward, B.S.O.T., Kansas Jill Fitzgerald Karen Parker University, 1972; M.Ed., University of Kim Fleming Kegina Ploucquet "A Missouri, 1976. Bill Gielow Becky Rapp

127 " I PHYSICIAN ASSISTANT PROGRAM, ST. LOUIS UNIVERSITY Washington University participates in the St. Louis University Physician Assistant Program administered ] through its School of Allied Health Professions. The 24-month program consists of three phases: preclinical sciences, clinical studies (didactic and practical), and a 20-week primary care preceptorship. Students are prepared to collect historical and physical data, perform diagnostic and therapeutic procedures, provide health maintenance services, and participate in patient education/ counseling activities. The goal is to produce individuals capable of assisting the primary care physician and extending the effectiveness of his medical practice. Pro- gram accreditation is granted by C. A.H.E. A. (Committee on Allied Health Education and Accreditation). For applications and further information contact: Director Physician Assistant Program School of Allied Health Professions St. Louis University 1504 S. Grand Blvd. St. Louis, Missouri 63104

128 I 5 PEDIATRIC NURSE PRACTITIONER L PROGRAM The School of Medicine through the Department of Pediatrics offers a program for preparing pediatric nurse practitioners in collaboration with the Department of Nursing of Maryville College. In addition to providing certification, the program provides the opportunity to obtain academic credit through Maryville College toward a baccalaureate degree in nursing. L The program was developed to help meet the challenge of needed health services in the pediatric community by preparing registered nurses to deliver primary pediatric health care. L The pediatric nurse practitioner (PNP) is a registered nurse whose special training enables her to play a larger role in pediatric health care. She obtains histories, performs physical examinations, and appraises physical, L psychological, and intellectual growth and development. The pediatric nurse practitioner is competent to counsel families in matters concerning nutrition, accident prevention, and child-rearing. With the physician, she partici- I pates in the management of acute and chronic illnesses. The program curriculum covers a nine-month period divided into a 16-week didactic portion followed by a 17-week practicum. The practicum may be obtained L through the facilities of the program or, by special arrangement, at the site of future employment for those nurses who are sponsored by an employer or agency guaranteeing an appropriate position upon the comple- L tion of the program. Supervised clinical practice is scheduled in a variety of settings, including public health clinics, neighborhood health centers, and private pediatricians' offices. Instruc- L tion is shared by medical and nursing faculties of Washington University and Maryville College. Applicants must be registered nurses with at least one year of nursing experience, preferably in pediatric nursing or public health nursing. On completion of the program, the PNP is qualified to serve wherever pediatric services are needed. The program has been accredited by the American Nurses Association, and complies with the guidelines for such programs as proposed by the Ameri- can Academy of Pediatrics and the American Nurses Association. L Program tuition (estimate) $2,850

129 PROGRAMS IN RADIOLOGIC registered nurses [RN], are presumed to have the neces- TECHNOLOGY sary credentials to meet the entrance requirements. The Department of Radiology, which has its head- Graduate Course in Radiation Therapy Technology quarters in the Edward Mallinckrodt Institute of Radiol- The Division of Radiation Oncology offers a 12- ogy, offers a basic course in X-ray technology and two month post-graduate course in radiation therapy tech- one-year postgraduate courses. Each course leads to a nology. This course consists of 260 hours of didactic certificate awarded by the Washington University School material plus extensive practical experience and training of Medicine, Department of Radiology. in the clinical application and dosimetry procedures of X-ray Technology radiation therapy. Approximately 1,400 new patients are This two-year program is approved by the American treated each year. The equipment includes a 35 M V linear Society of Radiologic Technologists, the American Col- accelerator, a Clinac 20 linear accelerator, a 4 M V linear lege of Radiology, the Joint Review Committee on Edu- accelerator, a cobalt unit, a superficial ortho-voltage cation in Radiologic Technology, the Council on Medical machine, and two simulators. Students obtain experience Education of the American Medical Association, and the on each of the therapy machines as well as in the dosim- Veterans Administration. It includes the following etry and treatment planning area and in nursing proce- courses: radiation protection, professional ethics, anat- dures. Two on-site computers are used for dosimetry and omy and physiology, nursing procedures, radiation phys- treatment planning computations. The students rotate ics, medical terminology, survey of medical and surgical through the physics and treatment planning service in diseases, radiographic positioning, darkroom processing addition to attending practical demonstrations. procedures, radiation therapy, radiation biology, nuclear medicine, special procedure radiography, room design and selection of equipment, and introduction to business Radiologic Technology Lecturer and Educational Director administration and personnel management. Course work Armand Diaz, R.N., R.T., Havana totals approximately 600 hours. University School of Medicine, 1948. During the first six months, a student is on proba- (See Department of Radiology.) tion. Upon satisfactory completion of this work, he will be paid a monthly stipend of $75 for the next six months. This stipend increases to $ 100 for the third six months and $125 for the last six months. During the 24 months, the student is assigned tours of duty in various diagnostic and therapeutic areas for practical experience, amounting to a total of 30 contact hours a week. Candidates for admission must be graduates of an accredited secondary school and should rank in the upper third of their class. Special consideration is given to graduates of schools of nursing that are recognized by the State Board of Nurse Examiners and to students who have passed a college entrance examination. A one-year postgraduate course is offered in the fields of therapy and nuclear medicine. Nuclear Medicine Technology This course covers 12 consecutive months, divided between didactic course material (225 hours) and practical experience. Persons admitted into the nuclear medicine technology program shall have completed high school, or its equivalent, and have completed post- secondary courses in the following areas: anatomy and physiology, basic physics, basic mathematics, medical terminology, oral and written communications, general chemistry, psychology and sociology, medical ethics, and jurisprudence. Qualified medical technologists [MT (ASCP) or eligible], radiographers [RT(R)(ARRT) or eligible], and

130 h

Gladys W. Levis Officers of the University Administration David S. Lewis Administration Lee M. Liberman William H. Danforth, A.B., M 1). The Board of Trustees Charles Lipton Chancellor George H. Capps Stanley L. Lopata Merle Kling, Ph.D. Chairman John P. MacCarthy Provost W. L. Hadley Griffin Vice Chairman Walter E. Massey John H. Biggs, A.B. Edwin S. Jones John F. McDonnell Vice Chancellor for Vice Chairman Robert H. McRoberts Financial Affairs Stanley R. Miller [ ] Harriet K. Switzer James W. Davis, A.B., Secretary I. E. Millstone M.P.A., Ph.D. Zane E. Barnes Hubert C. Moog Vice Chancellor and John R. Barsanti, Jr. John M. Olin Associate Provost Donald N. Brandin George E. Pake Samuel B. Guze, M.D. August A. Busch III Mary D. Pritzlaff Vice Chancellor for Maurice R. Chambers Louis S. Sachs Medical Affairs Sam B. Cook Edward J. Schnuck Herbert F. Hitzeman, B.F.A. William H. Danforth Armand C. Stalnaker Vice Chancellor for David C. Farrell Beulah S. Stamper University Relations Robert J. Glaser Elliot H. Stein John W. Hanley William K. Y. Tao Ralph E. Morrow, Ph.D. James L. Johnson, Jr. Charles A. Thomas Dean of the Faculty of Arts and Sciences George E. Kassabaum William H. Webster Charles F. Knight Margaret B. Wilson Harriet K. Switzer Donald E. Lasater Raymond H. Wittcoff Secretary

] 131 THE MEDICAL CENTER The Washington University 12 School ol Nuntag 24 IMcal CM Group 13 Shoenberg P«v«on 25 OccupaUorwl Thwapy Medical Center comprises six 14 SWnbwg P«»on School 15 VMdhffcn Clntct institutions: Barnard Free Skin arc Unhrersity 16 Ywm ".march BuWog 27 Rertard HnpU Medical Cantor BuUng WMttngton UnhmKy ai^OuMna 6 Swvtc* BuUng 17 School ol DanM HKMM » WbM HotpW and and Cancer Hospital, Barnes 7 School rtNuUng 8 Cenlrtl Irtttlufa kx Hospital, Central Institute for the t»DtH M Irene W. Jonmon Irwtrtute • EnbaneM 9 CHMrwVi HtwpM 20 MaNnduodl InriRult — Connecting Corridor* Deaf, Jewish Hospital of St. JmMiHoapiU 21555!™!!^^SS^L ©Pubic Parking 10 CWH MM Bulking Louis, St. Louis Children's Hos- pital, and the Washington Uni- versity School of Medicine. The Board of Directors William L. Edwards, Jr. Chairman / Lee M. Liberman* Vice Chairman Samuel B. Guze President Edward J. Schnuck Secretary Edwin B. Meissfier, Jr. Treasurer George H. Capps William H. Danforth Officers of the School of Medicine Morton E. Smith, B.S., M.D. John L. Davidson, Jr. William H. Danforth, A.B., M.D. Assistant Dean Ronald G. Evens, Chancellor G. Michael Timpe, B.S., M.B.A. Richard C. Grayson Merle Kling, Ph.D. Assistant Dean and Chief Financial Edward B. Greensfelder /Vows/ Officer and Assistant Vice Richard S. Jones Samuel B. Guze, M.D. Chancellor for Medical Affairs M. Kenton King Vice Chancellor for John D. Vavra, B.A., M.D. James S. McDonnell III Medical Affairs Assistant Dean for Post- Raymond E. Rowland Harold E. Thayer M. Kenton King, B.A., M.D. Graduate Training Raymond H. Wittcoff Dean John F. Walters, B.A., M.A. Virginia V. Weldon, A.B., M.D. Assistant Dean for Associate Vice Chancellor Student Affairs for Medical Affairs John L. Midkiff, B.S.B.A. Robert J. Hickok, B.S., M.H.A. Business Manager Assistant Vice Chancellor for Susan Y. Crawford, Ph.D. Medical Affairs Director of Library School of Medicine JohnC. Herweg, B.S., M.D. Associate Dean Mary L. Parker, B.S., M.S., M.D. Director of University Elmer B. Brown, Jr., A.B., M.D. Health Services Associate Dean for Continuing Medical Education Muriel L. Koch Administrative Assistant Mabel L. Purkerson, A.B., M.D. to the Dean Associate Dean for Curriculum Dorothy T. Rinderer Robert Lee, M.Ed., Ph.D. Administrative Assistant to L Assistant Dean for Minority the Vice Chancellor i: : Student Affairs Jean Stumbaugh John L. Schultz, B.S., B.S.Ed., Ruth T. Schmitz M.S., Ed.S., Ph.D. Assistant Registrars Assistant Dean in Academic Administration, Registrar, and Secretary to the Executive Faculty

132 __ FACULTY COUNCIL STANDING COMMITTEES1 Officers and The Faculty Council consists of all Committee on Student fulltime members of the faculty with Financial Aid Committees the rank of professor, associate pro- John C. Herweg fessor, assistant professor, and those Chairman instructors who have been on the Robert Lee of the Faculty faculty for at least three years. The John L. Schultz officers and executive committee are: John F. Walters EXECUTIVE FACULTY Penelope Shackelford William H. Danforth Chairman David Menton Chancellor Julio Santiago Committee on Academic Review Merle Kling Vice Chairman and Promotions I Selected faculty members Provost Barbel Holtmann L M. Kenton King Secretary Committee on Academic Review Dean and Promotions II James Marks Selected faculty members Samuel B. Guze Clinical Representative to the L Vice Chancellor for Executive Committee of the Committee on Academic Review Medical Affairs Faculty Council and Promotions III Selected faculty members Bernard Becker Bruce McLennan C. Elliot Bell, Jr.2 Clinical Representative to the Committee on Admissions John C. Herweg Joseph M. Davie Executive Committee of the L Chairman Philip R. Dodge Faculty Council Martin J. Bell Ronald G. Evens Patrick Murray Clinical Representative to the Nathan A. Berger Leonard Fabian L Executive Committee of the E. Richard Bischoff William R. Fair Faculty Council Barbara I. Brown Richard H. Fallon1 David Scharp Elmer B. Brown Gerald D. Fischbach Clinical Representative to the Mokhtar Gado Luis Glaser Executive Committee of the James R. Gavin Sidney Goldring Faculty Council Milton N. Goldstein John C. Herweg Julian Fleischman William F. Holmes Carlton C. Hunt Preclinical Representative to the $ Executive Committee of the John M. Kissane David M. Kipnis Faculty Council Robert Lee Paul E. Lacy William Sherman Stephen S. Lefrak William M. Landau Preclinical Representative to the John L. Schultz L Philip Needleman Executive Committee of the Joseph H. Ogura Faculty Council Ernest S. Simms Burton Singerman Robert E. Shank Elliot Bell Edward E. Vastola L Donald C. Shreffler Clinical Representative 2 to the Executive Faculty Ernest S. Simms John F. Walters Phillip Stahl Susan Wilson-Krechel James C. Warren Preclinical Representative John L. Schultz to the Executive Faculty Committee for the L. Recording Secretary David Geller Beaumont-May Representative to the Senate Institute of Neurology Council of Washington William M. Landau L: University Chairman Faculty Rights Committee Philip Cryer Paul DeWeer 'Parttime faculty representative to the Executive Faculty during 1981-82. 2 Representing the Faculty Council dur- 'The dean is ex officio a member of all ing 1982-83. standing committees.

133 Milton Goldstein Philip Whyatt Jean Stumbaugh K Edmund Hunter, Jr. Ray Witter ex officio Gerald Medoff Gary R. Zuckerman Mabel L. Purkerson Alternate ex officio Medical Science Training John Halverson John L. Schultz Placement and Curriculum Alternate ex officio Committee (MSTPCC) William McAlister Mabel L. Purkerson Committee for Laboratory Alternate Chairman, ex offtcio Animal Care David McDougal David H. Alpers M. Kenton King Alternate George Drysdale Chairman Committee on Fellowships and John C. Herweg David H. Brown Awards ex qfficio Phyllis M. Hartroft George R. Drysdale Chairman Richard E. Hillman Joseph E. Harvey Harvey R. Butcher Roy R. Peterson J. Neal Middelkamp William H. Daughaday John L. Schultz Alan L. Pearlman ex offlcio Alan L. Pearlman Roy R. Peterson Human Studies Committee Medical Scientist Training Mabel L. Purkerson John D. Vavra Program Committee Robert E. Shank Chairman Luis Glaser Ernest S. Simms Kenneth Arnold Program Director Eugene Bauer Carl Frieden Committee on Medical Co-Program Director Education Harvey R. Butcher Thomas J. Braciale Joseph M. Davie Lawrence A. Coben Irving Boime Chairman Leonard W. Fabian Paul J. DeWeer Bernard Becker Harold Gamble Elliot L. Elson Hugh Chaplin Martin Gardner J. Russell Little, Jr. Peg Cheadle David Goldring Student Representative David Schlessinger John L. Henshaw Anat Feingold W. Thomas Thach Dorothy J. Jones Student Representative John L. Schultz Carlton Hunt David W. Keller ex officio Lynne Kaminer Philip R. Ludbrook Ernest S. Simms James Marks Student Representative Teaching Program Coordination Richard Marshall Joan Larkins Committee Student Representative William McAlister Roy R. Peterson Paul Levine George E. Murphy Chairman J. Russell Little, Jr. Leonard Naeger William A. Frazier David Silbert Eli Robins Luis Reuss John C. Herweg Steve Rovak David W. Scharp ex officio Peter H. Ruger Gary D. Shackelford Mabel L. Purkerson Barry Siegel Thomas A. Woolsey ex officio Mildred Trotter John C. Herweg John L. Schultz Mary Tureen ex officio ex officio

U-4 Ashworth, William Dean, Jr., B.A., Black, William Howard, B.A., Register of University of Utah, '77—Salt Lake City, Washburn University, '77—Lawrence, Utah; University of Michigan Affiliated Kansas; Barnes Hospital, St. Louis, Hospitals, Ann Arbor, Michigan Missouri Students Barnett, Robert Eugene, B.S., Blackett, Melrose Ingle, B.A.. Brown Washington University, '78—Wakarusa, University, '78—Charlestown, Nevis, DOCTOR OF MEDICINE Kansas; Barnes Hospital, St. Louis, West Indies; University of Tennessee Missouri College of Medicine, Memphis, Graduate Becker, Steven George, B.S., Brown Tennessee July 17, 1981 University, '78—Hazel Park, Michigan; Block, Joel Arthur, B.A., University of No Medical Residency Ohio State University Hospitals, Chicago, '78—Wilmette. Illinois; Karp. Jeffrey W. M.S., Medical College Columbus, Ohio University of Chicago Clinics. of Virginia, '71, D.D.S., '71—Miami Beeson, Debra Ann, B.A., Denison Chicago, Illinois Beach, Florida University, '78—Brookfield, Illinois; Brown, Yolette Vanyce, B.S., The City Graduate University of Utah Affiliated Hospitals, College of City University of New York, August 28, 1981 Salt Lake City, Utah '76—New York, New York; St. Louis Residency 1982-83 Bellatti, John Walter, A.B., Illinois Children's Hospital, St. Louis, Missouri Grant, William T., A.B., Occidental College, '71—Riverton, Illinois; Burton, James Edward, HI, B.A., College '77—University of California University of Hawaii, Honolulu, Hawaii University of Rochester, '77— San Diego Affiliated Hospitals, San Benson, Robert Granger III, B.A.. Arlington, Massachusetts; Keesler AFB Diego, California University of Kansas, '78—Topeka, Hospital. Keesler AFB, Biloxi, Kansas; North Carolina Memorial Mississippi Graduating Class Hospital, Chapel Hill, North Carolina Carr, Kenneston, B.S., Georgia Institute May 21, 1982 Bermudez, Joseph Anthony, B.A., of Technology, '78—Conyers, Georgia; Alfino, Paul Anthony, A.B., Harvard College of St. Thomas, '78—Miami St. Mary's Hospital, San Francisco. University, '78—Chesterfield, Missouri; Beach, Florida; Oakland Naval California Temple University Hospitals, Regional Medical Center, Oakland, Carroll, Thomas Joseph, B.S., Iowa Philadelphia, Pennsylvania California State University at Ames, '73; M.S., '74; Arnall, Michael Frank, B.A.. University Birkenmeier, Thomas Mayer, A.B., Ph.D., University of South Dakota, of California at LaJolla, '77—Redlands, Washington University, '78— '79—St. Louis, Missouri; University of California; University of Colorado St. Louis, Missouri; Jewish Hospital, Iowa Hospitals, Iowa City, Iowa Affiliated Hospitals, Denver, Colorado St. Louis, Missouri Chang, Akemi Chu-Shih, B.S., Stanford University, '78—Los Angeles, California; Barnes Hospital. St. Louis, Missouri Chao, Ann Tien-Ling, B.S., Stanford University, '78—Anchorage, Alaska: University of Washington Affiliated Hospitals, Seattle, Washington Cohen, Alan Mathew, B.S., University of Illinois at Urbana, '64; Ph.D., University of Virginia, '69—Baltimore, Maryland; Jewish Hospital, St. Louis, Missouri Cook, Denise, A.B., Occidental College, '78—St. Louis, Missouri; Chicago Medical School Affiliated Hospitals, Chicago, Illinois Cormier, Lawrence Edward, B.A.. Case Western Reserve University, '75—New York, New York; Jewish Hospital, St. Louis, Missouri Cosulich, William Francis, Jr., B.S.E., University of Pennsylvania, '78— Syosset, New York; McGaw Medical Center, Chicago, Illinois Couch, Michael Wayne, B.S., Massachusetts Institute of Technology, '78—Wllow Grove, Pennsylvania; L University of Hawaii, Honolulu, Hawaii 135 L I Craig, Harry Randall, A.B.. Grinncll College. '78—Phoenix, Arizona; Jewish L' Hospital, St. Louis. Missouri Curry, Raymond Howard, A.B.. I University of Kentucky, '77—Lexington. Kentucky; McGaw Medical Center, Chicago. Illinois Dannenberg, Andrew Jess, B.S., Tufts University, '78—Great Neck, New York; b The New York Hospital. New York, New York Danziger, Eliot Jay, B.A., Wesleyan University, '78—New Hyde Park, New J York; Bronx Municipal Hospital Center, Bronx, New York Donzis, Paul Bennett, A.B., Princeton University, '78— Beverly Hills, ] California; University of California, San Fernando Valley, Scpulcveda, California Duncan, Eric DeWitt, B.A., Illinois Wesleyan University, '78—Polo, Illinois; McGaw Medical Center, Evanston. Illinois Dunkin, Pamela Ann, A.B.. Indiana University. '78—Glenview, Illinois; University of Colorado Affiliated Hospitals. Denver. Colorado Eby, Patricia Lynn, B.S., Georgetown University, '78—Gordonville. 1 Pennsylvania; Baylor College Affiliated Hospitals. Houston, Texas Ellis, Wilfred Joseph, B.S., University of Dayton, '75; M.S., '77—Dayton, Ohio; Wayne State University Affiliated Hospitals, Detroit, Michigan England, James Morris, A.B., Lafayette College. '64; Ph.D., Washington ] University, '70—Upper Darby, Goldmeier, David Joseph, B.A.. Halvorson, Gary David, B.S., Pennsylvania; Hospital of the University Dartmouth College. '78—Valley Stream. University of California at Davis, '78— of Pennsylvania. Philadelphia. New York; Barnes Hospital, Davis, California; McGaw Medical Pennsylvania St. Louis. Missouri Center, Chicago. Illinois Goodlett, Karen Larissa, B.S.. Furman Harten, James Nash, B.A., University of 1 Eresman, Robin Lee, B.S., University of University, '78—Moore, South Iowa at Iowa City, '77—St. Louis, Notre Dame. '78—Brewer. Maine; Carolina; George Washington University Missouri; New England Center University of Colorado Affiliated Hospital. Washington. D.C. Hospital, Boston, Massachusetts Hospitals. Denver, Colorado Gress, Daryl Ray, A.B.. Washington Hasselbring, Caryn Grace, B.S.P.T., Erickson, Nicolette Horbach, B.A., University. '78—Albion, Nebraska; Washington University, '74—St. Louis, Wellesley College, '78—Bellevue. Johns Hopkins Hospital. Missouri: McGaw Medical Center, Washington; University of California Baltimore. Maryland Chicago, Illinois Hospitals; San Francisco. California Griffith, Robert Fleming, Jr., B.S., Kent Hays, George Howard, Jr., A.B., Feuerstein, Irwin Marc, B.A.. Rutgers State University, '78—Stow. Ohio; William Jewell College, '77—Richmond. 5 University, '78—Matawan. New Jersey; Michael Reese Hospital. Chicago. Virginia; University of Missouri Medical Sinai Hospital. Baltimore. Maryland Illinois Center, Columbia, Missouri Fochtmann, Laura Josephine, B.S., Gutierrez, Nancy Lieb. B.S., Hitchcock, Thomas Floyd, B.A.. Washington University. '78—Creve Washington University. '78—Joliet. Greenville College, '78—Akron, New Coeur. Missouri; Johns Hopkins n Illinois: University of New Mexico York; Loyola University Affiliated Hospital. Baltimore. Maryland Hospitals. Albuquerque. New Mexico Hospitals. Maywood. Illinois Gautt, Rory Steven, A.B.. Washington Gutierrez, Ralph Aaron, B.A., Ho, Kau-Kwok Frederick, B.S., University, '78—Oklahoma City. University of Colorado. '78—Denver. California Institute of Technology, '77— Oklahoma; Michael Reese Hospital. Colorado; University of New Mexico Brooklyn, New York; Jewish Hospital. Chicago. Illinois Hospitals. Albuquerque. New Mexico St. Louis Missouri

136 Lewis, Jeanne Dahlen, B.S.. Gustavus Adolphus College. '61: Ph.D.. University of Wisconsin at Madison. '68—Lafayette. Colorado; Mercy Hospital, Denver. Colorado Lewis, John Malin, B.A.. Brigham Young University. 78—Wilmette, Illinois; Good Samaritan Hospital. Phoenix. Arizona Loar, Christopher Morton, B.S., Texas A & M University, 78—College Station. Texas; University of Texas Health Science Center, Houston, Texas Manary, Mark John, B.S., Massachusetts Institute of Technology. 77—Midland. Michigan; St. Louis Children's Hospital. St. Louis. Missouri Mam, Charles Stephen, B.A.. Hiram College. 78—Conneaut, Ohio; McGaw Medical Center. Chicago, Illinois Maylock, Fallon, B.A.. Johns Hopkins University. 77—Bowie. Maryland; George Washington University Hospital. Washington, DC McLean, Mary Susan, A.B.. Washington University. 75— Munster. Indiana; Medical College of Virginia. Richmond. Virginia Mealman, Terence Lee, B.S.. Stanford University, 78—Kansas City. Missouri: St. Luke's Hospital. Kansas City. Missouri Hockenbery, David Mark, B.S., Kamson, Solomon, B.S.. University of Meeham, Patrick John, B.A.. University University of Rochester, '78—Rochester, Michigan, 78—Ann Arbor, Michigan; of California at Santa Cruz, 78— New York; Johns Hopkins Hospital, Mercy Hospital, San Diego. California Tustin, California; Natividad Medical Baltimore, Maryland Keim, Stephen George, B.S., Mercer Center. Salinas. California Horn, Barbra Adrian, B.A.. Clark University. 78—Springfield. Virginia; Merlo, Clifford Joseph, B.S.. University University, 75—Elkins Park, Barnes Hospital. St. Louis. Missouri of Michigan. 77—Troy, Michigan; St. Pennsylvania; Barnes Hospital. Kerley, Suzanne Michelle, B.S., Luke's Hospital, St. Louis. Missouri St. Louis. Missouri Stanford University, 78—St. Louis. Mermel, Gary Warren, B.A.. Oberlin Hoynak, Bryan Clifford, B.A.. Wilkes Missouri: Barnes Hospital. College, 78—Skokie, Illinois; University College, 78—Lakeville. Pennsylvania; St. Louis. Missouri of California Davis, Sacramento, Columbia Richmond Co. Hospital, Kiessling, Lou Ann, B.S., University of California Columbia, South Carolina Michigan. 77—Jackson. Michigan; Michelson, Edward Allen, B.S., Michael Reese Hospital. Chicago, Hutchison, William G., B.A., University Massachusetts Institute of Technology. Illinois of Dayton, 78—Kettering. Ohio; Jewish 78—Randallstown, Maryland: McGaw Hospital, St. Louis, Missouri Killion, Douglas Joseph, B.S.. Medical Center. Chicago. Illinois University of Maryland. 75— Jiminez, Jose Francisco, B.A., Johns Vienna, Virginia: Barnes Hospital, Mink, Lisa Ann, B.A.. Macalester Hopkins University. 78—Baltimore. St. Louis, Missouri College, 78—Dundee. Illinois; St. Maryland; Baylor College Affiliated Mary's Hospital. Madison. Wisconsin Kraus, David Jonathan, B.S.. Yale Hospital. Houston. Texas University, 78—Larchmont, New York; Mink, Richard Bruce, B.A.. Franklin Johnsrud, Lorraine Alice, B.A.. Illinois Masonic Medical Center, and Marshall. 78—Flourtown. Carleton College, 74; Ph.D., Harvard Chicago. Illinois Pennsylvania; Children's Hospital, Washington, DC University, 78—Albert Lea, Minnesota; Kuhlengel, Keith Ralph, B.S.. Bradley Stanford University Hospital, University, 78—Trenton. Illinois; Morrison, Beverly Anne, B.A.. Webster Stanford, California Barnes Hospital. St. Louis. Missouri College. 76—St. Louis, Missouri; St. Kaminer, Lynne Susan, B.A., Lew, Brian Thomas, California Luke's Hospital. St. Louis. Missouri Washington University, 78- Morton Institute of Technology—Monterey Munger, John Speakman, A.M.. Grove. Illinois; Hospital of the Park. California; University of Princeton University, 78—Rumson, University of Pennsylvania. Minnesota Hospitals. Minneapolis, New Jersey; Grady Memorial Hospital, Philadelphia. Pennsylvania Minnesota Atlanta, Georgia

137 L r c Murphy, Mary Anne, B.A., Illinois Peters, Walter Russell, Jr., B.S.. Western Santmann, John Bryant, B.A., Johns Wesleyan University, '78—Ponliac, Illinois University, '78—Macomb, Hopkins University, '77—Babylon. New Illinois; St. Louis Children's Hospital, Illinois; Jewish Hospital, St. Louis, York; Highland General Hospital, St. Louis, Missouri Missouri Oakland. California r Neiharl, Robert Earl, B.A., Baker Pollei, Steven Ray, B.A., Luther Segal, Paul Miles, B.S., University of University, '78—Kansas City, Missouri; College, '78—Fon du Lac. Wisconsin; Pennsylvania, '78—Livingston, St. Luke's Hospital, Kansas City, LaCrosse Lutheran Hospital. New Jersey; University Hospitals. Missouri LaCrosse, Wisconsin Madison. Wisconsin c Neimeyer, John Hart, B.S.. Randolph, Lilly, B.S., South Carolina Shaw, Frederick Carl, B.A., Gustavus University of Michigan, '78—Cuyahoga State College. '78—Hopkins. South Adolphus College, '77—Clarksdale, Falls, Ohio; Barnes Hospital, Carolina; Barnes Hospital, Mississippi; University of Tennessee St. Louis, Missouri St. Louis, Missouri College of Medicine. Memphis. Ray, Daniel William, B.S., Vanderbilt Tennessee c Olsen, Mary Louise, B.S., University of University, '78—Nashville, Tennessee; Sherman, John Emery, B.A., St. Olaf Illinois, '78—Champaign, Illinois; Vanderbilt University Affiliated College. '78—LaCrosse. Wisconsin; University of Texas Affiliated Hospitals, Hospitals, Nashville, Tennessee University of Minnesota Hospitals, Houston, Texas Reed, Fred D., B.S.. Arizona State Minneapolis, Minnesota c Olson, Linda Marian, B.S.. Washington University. '78—Mesa, Arizona; Jewish Sherman, Stuart, B.A., State University State University, '76—Tacoma, Hospital, St. Louis, Missouri of New York at Binghamton, '77— Washington; Charlotte Memorial Douglaston, New York; Hospital Hospital, Charlotte. North Carolina Rice, Karen Hoxworth, B.A., Wellesley College, '78—Mexico, Missouri; Barnes University Health Center. c Organ, Paul Gerard, A.B., Harvard Hospital. St. Louis, Missouri Pittsburgh, Pennsylvania University, '78—Omaha. Nebraska; Ronish, Ross Henry, Carroll College— Simpson, Ross Wyatt, B.S., University Stanford University Hospital, Denton, Montana; University of North of Illinois at Urbana. '78—Woodstock, Stanford, California Dakota, Grand Forks, North Dakota Illinois; Mayo Graduate School, Pace, Denise Karin, A.B., University of Rochester, Minnesota c Rosenbaum, Peter Jon, University of California at Berkeley, '76—Oakland, Minnesota—Milwaukee, Wisconsin; Stein, Jeffrey Stephen, B.S., California; St. Louis Children's McGaw Medical Center, Evanston, Massachusetts Institute of Technology, Hospital, St. Louis. Missouri Illinois '78—Whitestone, New York; Mount Sinai Hospital, New York, New York Pan, Golden, B.S., Rice University, Rosenwasser, Tamzin Amadeus, B.A., r '78—Dallas, Texas; University of New College of the University of South Szeto, Albert Kwok Choy, B.S.E., California Hospitals, Los Angeles. Florida, '73—St. Louis, Missouri; Princeton University, '78—Hong Kong; California Barnes Hospital, St. Louis, Missouri Case Western Reserve University Hospital, Cleveland, Ohio Park, James Vance, B.S., University of Rubin, Jeremy Bennett, B.S., Stanford Colorado, '78—Lodi. Wisconsin; University. '77—Beverly Hills, Taylor, Lynne Patricia, A.B., University University of Texas Southwest Affiliated California; Cedars-Sinai Medical Center, of Illinois, '74—St. Louis, Missouri; Hospitals, Dallas. Texas Los Angeles. California Jewish Hospital, St. Louis, Missouri Tesi, Raymond Joseph, II, B.S., Utah State University, '77—Belle Vernon, c Pennsylvania; State University Kings Countv Medical Center, Brooklyn, New York ' Thomasson, Jeffrey Lee, B.A., c St. Louis University, '78—St. Louis. Missouri; St. Louis University Hospitals, St. Louis, Missouri Thompson, Van Eric, B.S., Washington University, 78—Ridgefield, Connecticut; Mayo Graduate School of Medicine, Rochester, Minnesota Thornquist, Robert Keith, Stanford University—Saratoga, California; Jewish Hospital, St. Louis, Missouri Townsend, Ronald Ross, B.A., University of California at Irvine, '77; B.S., '77—Anaheim, California; St. c Mary's Hospital, San Francisco, California Townsend, Susan Feldman, A.B., Radcliffe College, '77—Augusta, c Georgia; University of California Hospitals, San Francisco, California

138 r L L

Tung, Glenn Albert, B.A., Yale L University, 78—Olivette, Missouri; Brigham & Women's Hospital, Boston, Massachusetts Walker, Janet Margaret, B.S., Ohio L State University, 76—Mountain View, California; Medical Center Hospitals, Charleston, South Carolina Wanderman, Mark Joseph, B.A., State L University of New York at Binghamton, 77—Lawrence, New York; University of Colorado Affiliated Hospitals, Denver, Colorado Weiner, Marc Alan, B.S., Massachusetts L Institute of Technology, 78—DeWitt, New York; Cincinnati General Hospital, Cincinnati, Ohio Whaley, Dennis Ray, B.S., Emporia L Kansas State College, 77—Emporia, Kansas; Vanderbilt University Affiliated Hospitals, Nashville, Tennessee Word, Bonnie Marie, B.S., Chestnut Hill College, 78—Willingboro, New Chung, Mina Kay, B.A., University of Epstein, David Marc, A.B., Columbia Jersey; Children's Hospital, California at San Diego, 79—Monterey University, 79—Wilmington, Delaware Washington, DC Park, California Ertingef, Neil Allan, B.S., Vanderbilt Yeung, Horatio Him-Tai, B.S., Clanahan, James John, B.S., University, 79—Miami, Florida University of Wisconsin, 78— University of Illinois at Urbana, 79— Farber, Sharon Nancy, A.B., University Cerritos. California; University of Herrin, Illinois of California at Santa Cruz, 74; B.A., California, San Diego Affiliated Cohen, Mark Allen, A.B., Washington Hospitals, San Diego, California California State College at Sonoma. University, 79—Chicago, Illinois 78—San Francisco, California L Collins, Gregory, B.A., University of Fay, Mark Terence, B.S., North Dakota California at Santa Barbara, 75— State University, 79—Grand Forks, Bonita, California North Dakota Corteville, Jane Elizabeth, B.S., Third Year Class 1981-82 Feingold, Anat Rachel, A.B., Michigan State University, 79—Grosse Dartmouth College, 79— L Aprill, Brian Scott, B.A., Whittier Pointe Woods, Michigan Pittsburgh, Pennsylvania College, 79—Morton Grove, Illinois Cox, Janie Mae, B.A., Olivet Nazarene Feinstein, Steven Aaron, B.A.. Austin, Mark Bickford, B.S., University College, 79—Crawfordsville, Indiana LaSalle College, 79— of Michigan at Ann Arbor, 78— Crowe, Paul James, Carleton College— Philadelphia, Pennsylvania St. Louis, Missouri Minneapolis, Minnesota Fiedler, Brian S., B.S., University of Ballin, Daniel Spencer, B.S., Brown Davis, Andrew George, A.B., University, 78—Stamford, Connecticut Wisconsin at Madison, 79—Mt. Brandeis University, 79—Chevy Horeb, Wisconsin Benedett, Robert Edwin, B.A., Chase, Maryland Augustana College, 79—St. Fry, Edward T. A., A.B., Grinnell L Dewitt, Steven Keith, B.S., College, 79—Oak Ridge, Tennessee Charles, Minnesota University of Hawaii at Manoa, 79— Blatt, Mitchell Evan, B.Mus.A., Honolulu, Hawaii Fulwiler, Carl Edward, B.A.. Hofstra University, 78—Mt. Laurel, New Jersey University of Michigan at Ann Arbor, Doster, Sara Kathleen, A.B., Bryn 79—Camp Springs, Maryland Mawr College, 78—Clayton, California Groten, Dawn Marie, B.S., University of California at Davis, 78— Blum, Julia Elizabeth, B.S., University Dunagan, William Claibome, B.E.S., Campbell, California of Pittsburgh, 79—Curwensville, University of Texas at Austin, 78— Pennsylvania Monahans, Texas Hall, Jonathan Daniel, B.A., Miami Blumenthal, David Evan, B.A., Brown Dykman, Douglas David, B.E.S., Johns University, 79—Perrysburg, Ohio University, 79—Fayetteville, New York Hopkins University, 79, M.S., Johns Hamm, John Richard, B.A., Stevens Brown, Robert John, B.S., Saint Peter's Hopkins University, '80—Livingston, Institute of Technology, 71; Ph.D., College, 77—Jersey City, New Jersey New Jersey State University of New York at Stony Carpenter, David Adams, B.A., Eggert, Bryan George, George Brook, 78—Bronx, New York Amherst College, 79—Canandaigua. Washington University—West Deal, Hanko, Rodger Alan, B.A., University New York New Jersey of Colorado at Boulder, 79—Colorado Chelimsky, Thomas Charles, A.B., Emanuel, James Patrick, B.S., Springs, Colorado Harvard University, 79— University of Iowa. 77—Vermillion, Hansen, Keith Allen, B.S., Carroll Fairfax, Virginia South Dakota College, 79—Wall, South Dakota

139 North, Carol Sue, B.S.. University of Iowa at Iowa City, '76—Clinton. Iowa Ohtani, Robb Kenji, A.B., Occidental College. '79—Honolulu. Hawaii Parker, Christine Mershon, B.A., Carleton College. '79—Webster Groves, Missouri Parker, Katherine Anne, B.S.. Stanford University. '79—Webster Groves, Missouri Pearson, Michele Leontyne, B.A.. Emory University, '79— Jacksonville, Florida Harsch, John Arthur, B.S.. University of Kramer, Robert Scott, A.B., Harvard Pfeffer, David Michael, B.E.S.. Johns North Carolina at Chapel Hill, '78— University. '79—Creve Coeur, Missouri Hopkins University. '79—Hewlett, Atlanta, Georgia Krieg, Arthur Mertz, B.S., Haverford New York Haskel, Ethan Jay, B.S.. Brown College, '79—Hershey, Pennsylvania Prater, Thomas G., B.A.. Southern University, '79—Huntington, New York Laitman, Robert Steven, B.A.. Methodist University, '79— Hills, John Foster, Jr., B.A., Macalester Northwestern University, '79— Springfield, Missouri College. '75; M.S.. University of Wanamassa, New Jersey Puchalsky, David Ralph, B.S., Colorado at Boulder. '78— Lambie, Paul Benson, B.S., University University of Connecticut, '78— Littleton, Colorado Ninth Dakota. '79 Grand Forks, Boston. Massachusetts Horstman, William Glynn, B.S.. North Dakota Ragins, Mark, B.S.. California Institute L University of South Dakota at Landon, Patricia, A.B.. Washington of Technology. '79—Woodland Vermillion. '79—Parkston. University. '79—Yreka. California Hills. California South Dakota Link, Robert Nathan, B.S., Butler Ravenscraft, Mark Douglas, A.B.. Horwitz, Kenneth Bruce, A.B., University. '79—Dayton, Ohio Harvard University. '79—Fort Dartmouth College, '79— Lipinski, Irene Elizabeth, B.S.. Thomas. Kentucky Bethesda, Maryland University of Southern California at Roberts,Craig Stanley, B.S.. George Hubbard, Thomas Joseph, B.S.. Los Angeles. '79—Monterey Fox College. '79—Central University of Notre Dame, '79— Park. California Point. Oregon Dccatur, Illinois Lips, Daniel Lee, B.A.. University of Scanlan, Brian Edward, B.S.. University Iqbal, Vaseem, University of Michigan Oxford. St. John's College. '80— at Ann Arbor- London. England of Illinois at Urbana. '79— Faribault. Minnesota Hometown. Illinois Jacobs, Daryl I.arkin, B.S. Washington Luecke, Gail Anne, B.A.. Kalamazoo Schuster, Erika Dale, A.B.. Washington University, '77; M.S., Carnegie-Mellon College, '79—St. Louis. Missouri University, '75—Atlanta, Georgia University, '79—Broadview Malter, James Samuel, A.B.. Heights, Ohio Dartmouth College, '79— Schwartz, Benjamin, A.B.. Dartmouth Jantz, Jonathan Willard, B.A.. Bethel Boston, Massachusetts College, '79—Evanston, Illinois College, '79—Liberal, Kansas McCormick, Wayne C, A.B., University Seacord, Lynne M., A.B., Princeton Jenkins, Deborah Elaine, A.B.. Mount of Missouri at Columbia, '74—Webster University, '75—Scituate, Massachusetts Holyoke College, '79—Tulsa, Oklahoma Groves. Missouri Selland, Mark Alan, B.S.. University of Jenkins, Gregory Dean, A.A.. College Melamcd, David Michael, B.A.. North Dakota. '79— of the Cyns, '72. B.S. University State of Columbia University, '78—Chicago, Minot. North Dakota New York, '79—Newhall. California Illinois Shannon, Vicki Rene, A.B.. Smith Johnson, Jerry Avila, A.B., University Moitoza, David John, B.S.. University College. '79—St. Louis. Missouri of Michigan at Ann Arbor, '78— of California at Davis. '79— Encorse, Michigan San Pablo, California Shulman, Keith Lawrence, B.A.. Carleton College. '79—Highland Jones, Robin Doreen, B.A.. Rutgers Monroe, Harry Keith, B.S.. Creighton Park. Illinois University, '79- East Orange, University. '79—University New Jersey City. Missouri Siebens, David Phillips, B.A.. College of Kellis, Dana Sterling, B.S.. Brigham Moore, Kenneth Earl, B.S.. Georgetown Wooster. '78—Baltimore, Maryland Young University. '79— University. '79—Washington, D.C Maker. Dirk Paul, B.A.. University of Glendale. Arizona Morrow, Jason Drew, B.A., Vandcrbilt California-San Diego, '77— Kilmer, Helen Margaret, B.S.&B.A., University. '79—St. Louis. Missouri El Cajon. California Metropolitan State College. '79— Morton, Kenneth Laurence, B.S., Smith III, John Clair, B.S.. University Richardton. North Dakota Stanford University. '78—Kansas of North Dakota. '78— King, Thomas Ray, B.A.. Washington City. Missouri Minot, North Dakota University. '79—Winner. South Dakota Munro, Douglas Alan, A.B., Smythe, Sandra Jean, B.S., University L I Klem, Stephen Arthur, A.B.. Hope Washington University. '79—Grand of Wisconsin at Madison, '79'— College. '79- Deerfield. Illinois Junction. Colorado Austin, Minnesota

140 Spaitc, Daniel Wayne, B.A.. Point Second-Year Class 1981-82 Edelstein, Michael Charles, A.B.. Loma College, '79—Fresno, California Cornell University. '80—Silver Allen, Steven Robert, B.S.. Milligan Springs, Maryland Stark, Mark Edward, B.A.. College. '80—Tarpan Springs. Florida Northwestern University, "79— Edmunds, Laure, B.A.. Appelbaum, John Kenneth, B.A.. Fairview Heights, Illinois Johns Hopkins University. '80— St. Louis University. '80— Worcester. Massachusetts Steinhoff, Margaret Mary, B.A.. St. Ann. Missouri Washington University, '79— Eisen, Ruth Susan, B.A., University of Bailey, Thomas Charles, A.B., William Miami. Florida Pennsylvania. '80—Kew Gardens, Jewell College. '80—Liberty, Missouri Stene, Erik Nelson, B.A.. Augustana New York Barga, Bruce Edward, B.S., Washington College. '79—Crystal, Minnesota Ennen, Randy Mark, B.S.. University of State University, '77; M.S., University of Iowa, '80—St. Louis. Missouri Strzembosz, Andre Steve, B.S., Purdue Wisconsin at Madison. '80—St. University, '79—Hoopeston, Illinois Louis. Missouri Evans, Gregory, Herbert H. Lehman College of the City University of New Sullivan, Roger, B.S.. North Dakota Bigler, Carl Frederick, B.A., Williams York—New York, New York State University, '78—Grand Forks, College, '80—Garden City, Kansas North Dakota Eveloff, Scott Eugene, A.B.. Boos, Richard John, A.B., Washington Washington University, '80—Kansas Swarm, Robert Alexander, B.A.. University, '79—Clearwater, Florida Oberlin College. '77—Ridgewood, City, Missouri Bregg, Kenneth Joel, A.B., Washington New Jersey Francis, Joseph, Jr., B.A.. Johns University, '79—Clifton, New Jersey Taylor, Megan Beth, B.S.. University of Hopkins University, '80—New North Carolina at Chapel Hill, '78— Brent, Dale J., B.S., Yale University, Castle, Deleware Pittsburgh, Pennsylvania '80—Los Angeles, California Frank, Mark Steven, A.B.. Transylvania Tsaltas, Theodore T., B.S., Burgerman, Robert Stephen, B.S., University. '79—Somerset. Kentucky University of Pennsylvania, '78— Washington University, '79— Frank, Thomas Seymour, B.A. Villanova, Pennsylvania Bethesda, Maryland Northwestern University, '79— Vernon, Hazel Jane, B.A., Baylor Chien, Walter Waitak, A.B., Clayton. Missouri University, '79—Baton Washington University, '79—Kowloon. Friedman, Jon Robert, University of Rouge. Louisiana Hong Kong Pennsylvania—Wynlote, Pennsylvania Chun, Gary Paul, B.S.. Stanford Wilkerson, Donald Keith, A.B.. Gallagher, Christopher J., B.S., University, '77; M.S., Harvard Washington University. '79— University of Wisconsin at Madison. University, '80—Sacramento, California Memphis. Tennessee '80—LaCrosse, Wisconsin Close, James Michael, A.B., Winek, David Kent, B.S., University of Gray, Patricia Anne, B.S., University of Washington University, '80; A.B., '80— Wisconsin at Madison, '79— California at Irvine. '79— Edwardsville, Illinois Wauwatosa, Wisconsin Irvine, California Cole, Jenifer Wray, A.B., Washington Wollney, Dana E., B.S., Washington Greene, Laura Bari, A.B.. Washington University, '80—St. Louis, Missouri University, '79—Staten Island. University. '80; A.B., '80— New York Cole, Rhonda Audrey, B.A., Yale Osceola, Arkansas University, '80—St. Louis, Missouri Wu, Andrew Christopher, B.A.. Hansbrough, James Randall, B.S.. Johns Hopkins University, '79— Cooper, Mark Dale, University of Southeast Missouri State University, Memphis, Tennessee Oklahoma at Norman— '76. Ph.D., Vanderbilt University, '80— Yi, Hokyun, B.A.. Vanderbilt Pryor, Oklahoma Popular Bluff. Missouri University, '78 Nashville, Tennessee Cruvant, Ethan Milton, A.B., Harvard Herr, Robert Douglas, B.S.. Younkin, Casey Carrick, B.A.. Johns University, '80—Clayton, Missouri Yale University, '80— Hopkins University, '79— Droege, Gerard Francis, B.S., St. John's Kensington. Connecticut Springfield, Illinois University, '80—Washington, Missouri Hillery, Cheryl Ann, B.S.. University of Wisconsin at Madison, '80— Lancaster. Wisconsin Huang, Shirley Jane, B.S.. Stanford University, '80; M.S., '80—Delmar, New York Hvostik, George Robert, A.B.. University of Illinois at Urbana. '80; B.S.. '80—Berwyn. Illinois Jerabeck-Willert, Michael William, B.S., Georgetown University, '70— St. Louis, Missouri Jones, Robert W., B.S., Brigham Young University, '80—Orem. Utah Joyce, Stephen Thomas, Massachusetts Institute of Technology— Rochester, Michigan

141 c

Kennedy, Thomas Campbell, A.B., Mahony, Margaret Anne, B.S., Onufer, John Robert, B.S., University of Stanford University, '80— University of Illinois at Urbana, '80— Notre Dame, '80—Glenview. Illinois Yakima. Washington Toulon, Illinois Organ, Gregory Michael, B.S., Stanford Kent, Joseph H., B.S., University of Martin, Julie Ann, B.S.. Universi(y of University, '80—Omaha, Nebraska Notre Dame, '80—Oak Lawn, Illinois Washington, '80—Tacoma, Washington Pack, Michael Alan, B.A., State Kidney, Selwyn Anthony, B.S., State McAllister, John William II, B.S., University of New York at Binghamton, University of New York at Pittsburgh, University of Missouri at Columbia, '80—Brooklyn, New York '79—St. Augustine, Trinidad '80—Joplin. Missouri Penny, William Francis, Jr., B.A., Kirsch, William Arthur, B.A., McCool, Robert Edward, B.A., University of California at Los Angeles, Northwestern University, '80—Beech Greenville College, '77—St. '78—La Jolla, California Grove, Indiana Louis, Missouri Perednia, Douglas Alan, B.A., Klashman, David Jordan, B.S., Merine, Dimitri Serge, A.B., Columbia Swarthmore College, '79— Massachusetts Institute of Technology, University, '80—Brooklyn. New York Roseville, California '80- Newton, Massachusetts Mitchell, Gary Frank, B.A., Vanderbilt Polk, Mary Olivia, B.S.E., Duke Kogan, Melanie C, B.A., Johns University, '80—Kingsport, Tennessee University, '80—St. Louis, Missouri Hopkins University, '77—St. Moore, Charles Kevin, B.S., Indiana Powers, Timothy Bernard, A.B., Louis, Missouri University at Bloomington. '80— Washington University, '78—St. Kolodziej, Michael Alex, A.B., Kokomo, Indiana Louis, Missouri Washington University, '80—East Morehouse, Jeffrey Dean, B.S., Reichman, Alexandra lima, B.A., Chicago, Indiana Stanford University, '80— University of California at Berkeley, Langston, Amelia Ann, B.A., Williams Mesa, Arizona '80—San Francisco, California College, '80—Lakeland, Florida Morrell, Louise Ellen, B.A., Indiana Richter, James Robert, B.S., University l.arkins, Joan Marie, B.S., Stanford University at Bloomington, '80—Park of Nebraska at Omaha, '80— University, '78— Kentfield, California Ridge, Illinois Omaha, Nebraska I a tor i lie. Rosemay Therese, B.S., Natter, Lonny Ray, Brigham Young Ritter, Edmond Frederick, University of Carnegie-Mellon University, '80— University—Sunnyside, Washington Cincinnati—Cincinnati, Ohio Washington. D.C. Nii, Lenore Tomoye, B.S., University Robinson, Gordon Howard, B.A., Lawrence, Michael Kevin, B.S., of California at Los Angeles, '80— St. Louis University, '80— Northwestern University, '80— Dinuba, California St. Louis, Missouri Elgin, Illinois Obeid, Robert James, B.M.Sc.. Emory Rollins, Edward Sterling, B.A., I a/an, David Walter, A.B., Washington University, '77—St. Louis, Missouri University of California at Davis, '80— University, '76—Hewlett, New York Okun, Neil Jeffrey, A.B., Dartmouth Woodland, California Lee, Robert Alan, B.S., University of College, '80—St. Louis, Missouri Rollins, Susan Davidson, B.S., Illinois at Urbana, '80— Davidson College, '80—St. Louis, Prophetstown, Illinois Missouri I I'liii.ui. Steven Elliot, B.A., Rutgers Rosenthal, John Gregory, B.S., University, '80—Paramus, New Jersey University of Notre Dame. '80— Leung, Cheung Kwok, B.S.. University St. Louis, Missouri of Illinois at Urbana, '74; M.S.E., Ross, Theodore, B.A., Mississippi University of Michigan at Ann Arbor, Valley State University, '80— '75—St. Louis, Missouri Tchula, Mississippi Lindemann, S(even Roger, B.S., Ross, Willie Ray, B.A., Yale University, Washing(on University, '80— '80—Memphis, Tennessee Cincinnati. Ohio Rowley, Howard Andrew, B.S., Linder, Barry J., B.S., Massachusetts University of Illinois at Urbana, '80— Institute of Technology. '78; M.S., Lockport. Illinois University of Connecticut. '80— Ruben, James Bradford, B.A., Lenox. Massachusetts University of Colorado at Boulder, Loeffler, Roberta Lynn, B.S., Emporia •80—Rye, New York State University. '78; M.S., Purdue Saltzman, Andrew Kenneth, A.B., University. '80—Newton. Kansas Washington University, '80—Flushing, Loper, Keith Allen, B.A., University of New York California at Berkeley, '80—Rolling Scannell, Lynne Marie, B.A., University Hills, California of California at Davis, '80—San Lubarsky, David Alan, B.A., Rafael, California Washington University, '80— Schick, Karen Sue, B.S., University of Scarsdale, New York Kansas, '80—Wichita. Kansas Maguire, Kathryn Lael, B.S.. Schwartz, Daniel Richard, B.A., Washington University, '80— Hamilton College. '80—Scarsdale, Manchester, Missouri New York

142 First-Year Class 1981-82 Armistead, Joseph Jackson, B.S., Washington University, '81—Olive Branch. Mississippi Auchus, Alexander Patrick, B.A., Johns Hopkins University, '81—Totown, New Jersey Azrin, Michael A., B.S., Brandeis University, '81—Carbondale. Illinois Baudendistel, Allen D., A.B.. St. Louis University, '81—St. Louis. Missouri Belnick, Lucille B., A.B., University of California-Berkeley, '77—Berkeley, California Bennett, Vera Elizabeth, A.B.. Harvard University, '81—Bloomfield, Connecticut Buck, Gregory William, B.S., Morehouse College, '81—Atlanta. Georgia Cave, Anita Margaret, B.S., Trinity University, '73, B.A., Washington University,'81—Princeton, Texas - Celin, Scott Edward, B.S., University of Pittsburgh, '81—Pittsburgh, Pennsylvania Chang, Elise Sophia, A.B., Harvard University, '78—San Francisco, California Chang, Thomas Sehoon, B.S.. Massachusetts Institute of Technology, '81—Rockville, Maryland Cohen, Jeffrey, B.A., Washington University, '80—Plantation, Florida Collin, Gary Richard, B.A., Dartmouth Schwartz, David Brian, B.S., University Tobler, Randall Wayne, B.A., University College, '81—Guttenberg, New Jersery of Michigan at Ann Arbor, '80— of Missouri at St. Louis, '80—St. St. Louis, Missouri Louis, Missouri Colombo, Mark Anthony, B.A., Johns Hopkins University, '81—Aurora, Ohio Seidcn, Michael Can, B.A., Oberlin Toliver, James Edward, Jr., B.A., Johns College, '80—Pittsburgh, Pennsylvania Hopkins University, '80—St. Coplen, Sharon Elizabeth, B.S., Butler University, '81—Warsaw, Indiana Sila, Mehmet Kaya, B.A., Swarthmore Louis, Missouri College, '80—Towson, Maryland Travis, Mark Stephen, B.S., University Demonchaux, Elisabeth Lucille, B.A., of Illinois at Urbana, '80— Northwestern University, '81—Topeka, Slack, Stephen Francis, A.B., Chicago, Illinois Kansas Dartmouth College, '80— Louisville, Kentucky Tung, Rebecca Lillian, A.B., Radcliffe Durant, Lynette Lee, B.A., Tuskegee College, '80—St. Louis, Missouri Snower, Daniel Perry, A.B., Institute, '81—Christiansted, Virgin Washington University, '80— Uraneck, Katherine Irene, B.S., Cornell Islands Shawnee Mission, Kansas University, '80—Bartlesville, Oklahoma El-Badry, Amr Morry, B.A., Haverford Vehe, Richard Karl, B.S., University of Suba, Eric John, A.B., Princeton College, '80—New York, New York Wisconsin at Madison, '80—Mt. University, '80—St. Louis, Missouri Prospect, Illinois Faber, Kathy Lynn, B.A., Calvin College, '81—Grand Rapids, Michigan Surratt, Robert Stephen, B.A., Wainz, Ronald John, B.S., University of Vanderbilt University, '80— Dayton, '80—Springfield, Ohio Ford, Neville Finch, B.S., University of Jackson, Mississippi Wilson, Carl Thayne, B.S., Brigham Bristol, '55, Ph.D., University of Bristol, Tartell, Paul Brendan, A.B., Young University, '77—Provo, Utah '58—Millington, New Jersey Washington University, '80— Wirt, Gregory Thomas, A.B., William Frost, Timothy William, B.A., Duke Elmhurst, New York Jewell College, '80—St. Louis, Missouri University, '81—Dunwoody, Georgia Thompson, James Anderson, B.S., Wright, Cheryl Danita, B.A., University Gaines, Sharon Elaine, B.A., Atlantic University of Illinois at Urbana, '80— of California at San Diego, '80—San Union College, '81—Nashville, Chicago, Illinois Diego, California Tennessee

143 C.l Gitelman Darren Ross, B.A., Washington University, '81—Brooklyn, New York Goldblum, Kenneth David, B.A., - Washington University, '80—Broomall, Pennsylvania Griffith, Patrick Keith, B.A., Northwestern University, '81—Chicago, Illinois Grow, Pamela Keller, B.A.. University of Nebraska, '80—St. Louis, Missouri Hale, Kenneth Douglas, A.A., Glendale College, '74. B.A., California State J University, Northridge, '80— LaCrescenta, California Heifer, Donald Lee, B.A., University of Illinois, '81 — Morton, Illinois Hershey, Jonathan Marc, B.A., Johns Hopkins University, '81—Glencoe, Illinois Himelstein, Andrew Louis, B.A., Harvard University, '81—Garden City. New York Hing, Andrew William, B.A.. Duke University. '81—San Jose, California Hingsbergen, Elizabeth Ann, B.A., Northwestern University, '81 — L Delaware, Ohio Hopson, David Kent, B.S., Southeast Missouri State University, '80— Chesterfield, Missouri Huppenbauer, Bob, B.A.. University of California-Berkeley. '80—Plymouth. Michigan Huppert, Jill Suzanne, B.A., Johns Hopkins University. '81—Perry Hall. Maryland Hutchison, Anne Victoria, B.A., Capital University, '81— Livonia. Michigan Jankowski, Dorian Elaine, B.S.. L Massachusetts Institute of Technology, '80— Highland Springs, Virginia Jarka, Robert Michael, B.S.. University Koch, Gregory Edward, B.A., Lund, Jr. Herluf Gyde, B.A.. Tufts of Nortre Dame. '81—Grand Rapids, L University of California-Irvine. '77, B.S.. University, '78—Frontenac. Missouri Michigan University of California-Irvine, '81 — Machlin, Steven Robert, B.A., Johnson, Corbin Ross, B.A., Harvard Irvine, California Washington University, '81—Livingston. University, '81—N. Miami Beach, Kritz, Alan Daniel, B.A.. University of New Jersey Florida Pennsylvania. '81—Baldwin, New York L: Manber, Yvonne Marie, B.S., B.A.. Jones, Dennie Vance, B.S.. Washington Larson, Leann Janet, B.A., St. Olaf University, '81—Chicago, Illinois University of Illinois, '81—Canton, College, '80—Madison. Wisconsin Illinois Jones, Sheila Bertha, M.S.. Yale Lenzi, Victor Daniel, B.S.. University of University. '80—Philadelphia. Illinois. '81—Farmington. Illinois Mathews, Karen Michelle, B.S., Bowling Green State University, "81 — Pennsylvania Levisohn, Dianne Rae, B.A., Dayton, Ohio King, Karl Wei-Han, B.A.. Washington Washington University, '76—Lakewood, University. '80—Omaha. Nebraska Colorado Melnyk, Christine Marie, B.S.. Klein, Marisa Sue, B.A., Stanford Litwin, Sheldon Ellis, B.S., Colorado University of Illinois, ^l — University. '80—Aptos. California College. '81—Topeka. Kansas Dixon. Illinois Klein, Mitchell Alan, B.A.. Washington Locke, Susan Marie, B.A., Washington Mensah, George Akowua, B.A., University, '81—Pembroke Pines, University, '81—University City, Harvard University. ^0—Kokofu, Florida Missouri Ashanti. Ghana 144 2 LJ

Mini, Robert Louis, B.S., M.S.. Yale Sikich, Linmarie, B.A.. Washington Thulborn, Keith Raymond, B.S.. University, ^l—Convent Station. University, "81—Potosi. Missouri University of Melbourne. 76—Victoria, New Jersey Sivier, Robert Alan, B.A.. Illinois Australia Muchmore, Heather Edwina, B.S., Wesleyan University. "81—Mahomet. Tobin Garry Stuart, B.S., University of University of Illinois, '81 — Illinois Missouri-Rolla. '81—St. Louis, Missouri Carbondale, Illinois Smart, Steven Craig, B.A.. Harvard Villanueva, Merceditas Santos, B.A.. Nattiv, Aurelia, B.S., University of University, '81—Milwaukee. Wisconsin Harvard University, '81—New York. California—Los Angeles. '81—W. Los Smith, Page Armand, B.A., University New York Angeles. California of California. '77—San Francisco, Volck, Brian Edward, B.A.. Washington Noordsy, Douglas Louis, B.S.. St California University. "81—Cincinnati. Ohio Lawrence University, "81—Dewitt. Steele, Dean Wesley, B.A.. Washington Watson, Blanche Evangeline, B.A.. New York University. '81—Anchorage. Alaska Washington University, 77—Los Nordlund, John Richard, B.S.. Angeles. California Stern, Richard Curtis, B.A., Brandeis Rensseiaer Poly Institute, 75—St. University, '81—Valley Stream, Weiss, Peter John, B.A.. Washington Louis, Missouri New York University. '81—St. Petersburg. Florida Nowotny, Thomas John, B.S.. Whiting, David Wade, B.S., Stanford Stevens, Jr. John Kirwin, B.S.. Washington University, '80—St. University. '81—Stanford. California Louis. Missouri Washington University. "81—St. Louis. Missouri Willerford. Dennis Michael, B.A.. O'Neill, Conor William, B.A., College of University of California. "81 — St. Thomas. "81—St. Paul. Minnesota Strickland, Adrianne Patric, B.A.. Duke Kensington. California University, '81—Tampa, Florida Pearlstone, Anthony Craig, B.S.. Winokur, Patricia Lee, B.A.. Brown Washington University, '81—Creve Sun, Francis Roma, B.S., University, '81—Iowa City. Iowa Massachusetts Institute of Technology, Coeur. Missouri Wolford, Thomas Leo, B.A.. St. Louis '81—Hebron. Indiana Pennington, MaryJane, B.S., Duke University. 76—Louisville. Kentucky University, 81—Birmingham. Alabama Swanson, Todd Victor, B.A.. Augustana Wong, Ella Hoy, B.S.. Caltech College. "81—Brooks. South Dakota Pitts, Eric Wayne, B.A., Yale University, University. 78—Skokie. Illinois "81—Kansas City, Kansas Szeles, Leslie Steven, B.A.. Dartmouth Wren, Megan Elizabeth, B.A., College, "81—Granite City. Illinois Pohl, David Lee, B.A., Miami Washington University. '81 — University, 76—Osgood, Ohio Tannin, Grace Michele, B.A., Pennington. New Jersey Washington University. "81 — Randle, Gregory Clayton, B.A., Yerman, Howard Mark, B.S.. University Chappaqua, New York Washington University. '81—St. of Michigan. "81—Oak Park. Michigan Louis. Missouri Tenaglia, Alan Nicholas, B.S.. Zuckerman, Jordan Spence, B.A., University of Pennsylvania. '78— Washington University. "81—Bayside. Resta, Regina Marie, B.A.. Washington Philadelphia. Pennsylvania New York University. "81—Brooklyn, New York Rokaw, Joshua Alan, B.A.. Washington University. "81—Downey. California Roth, Judith Ann, B.S.. Indiana University, 76—St. Louis. Missouri Summary of Students in the School of Medicine, 1980-1981 Rurik, Gregory, B.S.. Stanford Graduate—June 6, 1980 1 University. "81—Fresno, California Graduate—December 12, 1980 I Sande, Craig Martin, B.S.. Stanford Graduate—January 16, 1981 1 University, ^1 — Reno, Nevada L Graduating Class—May 22, 1981 Scates, Steven Michael, A.A., Modesto Doctor of Medicine Degree 124 Junior College. 75, B.S., University of Doctor of Medicine and Doctor of Philosophy Degrees 9 California. 78—Modesto. California Doctor of Medicine Degree Schertz, Larry David, B.A.. Third Year Class 129 Northwestern University, ^1 — Second Year Class 108 Lombard. Illinois First Year Class 109 Scholz, Thomas Dean, B.S., Medical Scientist Training Program Swarthmore College, "81—Clarendon Hills, Illinois Doctor of Medicine and Doctor of Philosophy Degrees Seventh Year Trainees 2 Sedlack, Jeffrey David, B.A., Northwestern University, "81 — Sixth Year Trainees 3 Rochester. Minnesota Fifth Year Trainees 8 Shapiro, Michael Alan, B.A.. Fourth Year Trainees 10 Dartmouth College, "81—Watchung. Third Year Trainees 6 New Jersey Second Year Trainees II Shields, Steven Miller, B.S., Washington First Year Trainees l_3 University. "81—El Dorado. Kansas Total 535

145 DOCTOR OF MEDICINE Seventh-Year Trainee 1981-82 Kreisle, Regina Ann, B.A.. Kalama/oo AND DOCTOR OF Schwob, James Edward, B.S., College. 77—South Bend, Indiana PHILOSOPHY DEGREES University of Iowa, '75—Iowa Mellis, Scott Jeffrey, B.A., Johns Hopkins University, 77—Hempstead. Medical Scientist City, Iowa New York Training Program Sixth-Year Trainees 1981-82 Neil, Jeffrey Joseph, A.B., Washington Graduates—May 22, 1982 Barshop, Bruce Allen, A.B., Brandeis University, 77—North Olmstead, Ohio Gibson, Ronald Lyne, Jr., B.S., University, 76—Freehold, New Jersey Reitman, Marc Lionel, B.S.. University of Washington, 75—Seattle, Bloch, Michele Helene, B.S., Cornell Massachusetts Institute of Technology, Washington University, 76—Flushing, New York 77- Stanford. Connecticut Hempstead, Barbara Louise, B.A., Tufts Boothby, Mark Robin, B.S., University Rothenberg, Paul Louis, B.S., Cornell University, 76—Andover, Massachusetts of Wisconsin, 76—St. Louis, Missouri University, 77—Douglaston, New York Kane, William Harrison, B.S.. Hortin, Glen Lee, B.S., Illinois State Tait, Jonathan Francis, A.B.. Harvard University of Iowa, 76 Iowa City. Iowa University, 76—Zion Illinois University. 77—Salisbury, Connecticut Lebovitz, Russell Martin, B.S.. Natowicz, Marvin Roy, A.B.. Weinman, Steven Alan, A.B., Harvard L University of Michigan, 75—Pittsburgh, Washington University. 76—Oak Park, University, 77—Elmont, New York Pennsylvania Michigan Schieber, Marc Hudson, A.B., Fourth-Year Trainees 1981-82 Washington University, 74—Winter Fifth-Year Trainees 1981-82 L Park, Florida Faustman, Denise Louise, B.S.. Ginsberg, Ann Meredith, A.B., Udey, Mark Charles, B.S., University of University of Michigan, 78—Dearborn Radcliffe College, 77—New York, Heights, Michigan t Wisconsin at Madison, 75—Fort New York Atkinson, Wisconsin Karp, David Ross, B.S., Massachusetts Hofman, Sandra Lee, B.A., University Institute of Technology, 78— L of Virginia, 77—Monroeville, Northfield, Ohio Eighth-Year Trainee 1981-82 Pennsylvania King, Thomas Charles, B.A., [ Rubin, Jeffrey Steven, A.B., Harvard Kastan, Michael Barry, B.S., University Washington University, 78—Rancho University, '74, A.M., '74- New York of North Carolina, 77—Chapel Hill, Palos Verdes, California L City, New York North Carolina Kleinschmidt, Donn Craig, B.A., University of Wisconsin at Madison, c 75—University City, Missouri Klunk, William Edward, B.A., L Shippensburg State College, 78— Hanover, Pennsylvania I Milstone, Dave Stanley, B.A., University of California at Santa Barbara, 76—Mountain View, California I Third-Year Trainees 1981-82 L Darnell, Robert Bernard, A.B., Columbia University, 79—Larchmont, I New York Floeter, Mary Kay, B.S., University of L Illinois at Urbana, 78—Crystal Lake, Illinois Goldberg, Daniel Eliot, A.B.. Harvard I University, 78—Brookline, Massachusetts Harding, Clifford Vincent, A.B., Harvard University, 79—Detroit, r Michigan Hollifield, William Claude, Jr., B.S., L University of California at Berkeley, 74, M.A., 78—Sacramento, California Lentz, Steven Russell, B.S., Iowa State University of Science and Technology, 79—St. Paul, Minnesota Ling, Richard Takkam, B.A., Johns c Hopkins University, 79—M.A., 79— Hong Kong

146 s ] Health Administration and Planning Program Part-Time Students 1981-82 Brooks, Sue W., B.A., Michigan State University, '69; M.A., Michigan State University, '70—St. Louis, Missouri if Collins, John W., B.S., St. Louis College of Pharmacy, 77—St. Louis, Missouri Golden, Michael G., B.B.A./B.A., University of Notre Dame, HI— St. Louis, Missouri Jansson, Susanne E., B.A., SUNY University, '76; M.A., Hofstra University, 79—Brentwood, New York Jewell, Robert E., B.A., Cardinal Glennon College, 71—East St. Louis, Illinois Johnson, Joan Carter, B.A., University of Pennsylvania, '64; M.S., Southern Connecticut State, 73—St. Louis, Missouri Martin, Paul Langlie, A.B.. Harvard First-Year Trainees 1981-82 Moss, Grover Zack, B.S., Southern University, 79—New Britain. Baum, Charles Michael, B.A., Colorado Illinois University, 79 Connecticut University, '80—Denver, Colorado Nations, David W., B.A., Webster Nelson, Raoul Devin, B.A., St. Olaf Behlke, Mark, B.S., Massachusetts College, HO—St. Louis, Missouri College, 79—Bloomington, Minnesota Institute of Technology, HI—El Siffring, Connie K. B.S., College of St. Paso, Texas Neufeld, Ellis Jacob, B.A., Wesleyan Mary, 74—Rising City, Nebraska University, 79—Bethesda, Maryland Chou, Hubert Shin-Han, B.S., Zoller, Gregg G., B.S., Marquette University of California-Irvine, HI — Usdin, Ted Bjorn, B.A., Johns Hopkins University, 77; M.S.P.A., University of Santa Ana, California University, 78—Arlington, Virginia Missouri-Columbia, '80—Milwaukee, Corless, Christopher Lee, B.A., Wisconsin University of California-Berkeley, HI — Second-Year Trainees 1981-82 Orinda, California Arkin, Martin Samuel, B.S., University Faust, Phyllis Lynn, B.A., State First-Year Class 1981-82 of Michigan at Ann Arbor, '80—Novi, University, '80, B.S., Clarkson College, Anderson, Gary W., B.S., Brigham Michigan HI—Locust Valley, New York Young University, '81—Provo, Utah Barr, Frederic Glenn, B.A., Williams Grant, Paula, B.S., Catholic University, Boles, Mark D., B.S., Ohio State College, '80—Baltimore, Maryland HI—Stratford, Connecticut University, 76—Cuyahoga Falls. Ohio Boguski, Mark Stanley, B.A., Johns Green, Eric Douglas, B.S., University of Bruhn, Susan M., B.S.N., University of Hopkins University, 76—Clayton, Wisconsin, HI—Frontenac, Missouri Missouri Wisconsin, 79—Madison, Wisconsin Henkel, Timothy John, B.S., Chan, Andrew Chee-Yuen, B.A., Chandler, Richard H., BED. A., North Southwestern College, HI — Carolina State, '75—Charlotte, North L Northwestern University, '80—M.S., Lawrenceburg, Tennessee '80—Irvine, California Carolina Kane, Steven, B.S., Miami University, Lang, Leslie Mark, A.B., Brandeis Coffman, Cheryl, B.S.N., St. Louis HI—University Heights, Ohio University, HI—Manchester, Missouri University, 79—North Bergen, Macarthur, Craig Alan, B.S., University Crahan, Dorothy K., B.A., St. Louis L New Jersey of California-Berkeley, '81—Berkeley, University, 71—St. Louis, Missouri Lukacher, Aron Eliot, A.B., Brandeis California University, "80—Rochester, New York Mink, Jonathan Walter, B.A., Wesleyan DeYoung, Joy M., A.B., Stanford Mirski, Marek Alexander, B.S., University, HO—St. Paul, Minnesota University, '81—Bay City, Michigan Massachusetts Institute of Technology Selleck, Scott Brian, B.A., University of Dude, Kenneth M., B.S., University of "80—Washington, D.C. Washington, 79—Seattle, Washington Illinois, '81; B.A., University of Illinois, HI—Park Ridge, Illinios Simmons, Barbara Marie, B.A., Johns Smith, Roderic Lee, B.A., Harvard Hopkins University, "80—St. University, HO—Port Isabel, Texas Fritzshall, Alan J., B.S., Southern Louis, Missouri Illinois University, HI—Skokie, Illinois Taniuchi, Megumi, B.S., M.S., Yale Starren, Justin Bruce, A.B., Washington University, HI—Bethesda, Maryland Gauss, David L., B.S., SUNY at University, '80—San Diego, California Tripp, Catherine Susan, B.A., University Buffalo, '81—Spencerport, New York Wilson, David Brian, B.A., Kalamazoo of New Hampshire, '78—St. Louis, Glow, Robert J., B.A., Creighton College, -80—Winfield, Illinois Missouri University, '81—Omaha, Nebraska

147 Gosser, Bruce M., B.S., Northeast Meyer, Steven M., B.A.. St. Louis Reifsteck, Mark W., B.A., Cardinal Missouri State, '70; M.Div.. Phillips University, '77—St. Louis, Missouri Glennon College, '77—St. Louis. University, '72; M.A., Wake Forest Murrell, John J., B.S., Georgetown Missouri University, '75—St. Joseph. Missouri College, '81 —Middlesboro. Kentucky Roth, Patricia L., B.A., Trinity Harris, Margaret J., B.A., University of Paul, Jerry W., B.A.. Elmhurst College. University, '81—St. Louis. Missouri Iowa, '57—Galesburg, Illinois '71; M.Div., Eden Theological Russell, Kimberly, B.S., Purdue Hetlage, Charles K„ B.A., DePauw Seminary, '74—Schofield, Wisconsin University, '81—Rocky River, Ohio University, '81—St. Louis, Missouri Paul, Rashel D„ B.S., St. Xavier Scrivner, Robert A., B.A., Columbia Joseph, Nesakumar, Diploma in College, '79—Chicago. Illinois College, '78—St. Louis. Missouri Personnel Management, Xavicr Labour Phegley, Timothy L., B.S., Shattes, Wayne S., B.S., State University Relations Institute, India, '77—Vellore, Massachusetts Institute of Technology, College of New York, '78—Huntington. India '71; M.S., Harvard School of Public New York Kantcr, Beth H„ B.A.. Drake Health, '76—St. Louis, Missouri Smith, Pamela K., B.S.B.A., University, '81—Winnetka, Illinois Phillipi, David W„ B.S.. Murray State Washington University, '81—Basking Lee, Edward, B.A., College of University, '79—Quincy, Illinois Ridge. Nebraska Medicine, National Taiwan University, Pool, Christopher, B.S., Florida State Teig, Carol D„ A.B., Washington '80 Taichung, Taiwan University, '72; M.B.A., Golden Gate University, '70; A.M., Washington Leiberton, Margaret, B.S., University of University. 79—Ft. Walton Beach. University, '71—St. Louis, Missouri Pittsburgh, '81—Chcswick. Florida Yang, Juinhong, B.A., National Taiwan Pennsylvania Pritts, Robert W., B.A., University of Institute, '79; M.A.. Virginia Mann, Ethel L., B.A., Tennessee State Puget Sound. '80—Boulder City, Polytechnical Institute, '81—Changhwa. University, '78—Brownsville. Tennessee Nevada Taiwan

PROGRAM IN PHYSICAL THERAPY Senior Class 1981-82 Barnard, Kammi Lyn, Indiana University—Rushville, Indiana Barton, Joan Patrice, Montana State University—Oak Brook, Illinois Biver, Deborah Jean, Belleville Area -»Emerger College—Belleville, Illinois Bontz, Melanie Eleanor, University of Illinois—Mapleton, Illinois -^ Public Parking Brown, Karen Charlotte, University of Maryland—Bethesda, Maryland ► Jewish Hospi Caruso, Timothy John, University of Illinois Chicago, Illinois Barnes Hospital Clanahan, Mary Beth, University of Illinois—Herrin, Illinois Central Institute Dallal, Donna Margaret, B.A., For The Deaf Washington University, '76—New Hartford, New York Children's Hospital Darnauer. Kathleen Rose, Washington University—Ft. Washington, Maryland School Of Medicine Delaney, Debora Ann, Southern Illinois University—Herrin, Illinois Medical Care Group Grossmann, Jeanine R„ Indiana School of Dental University—Jennings, Missouri Huff, Katherine Ann, James Madison Medicine University—Wilkinsburg, Pennsylvania Jenkins, Jill Elizabeth, Washington University—St. Louis, Missouri Lechner-Lewis, Cynthia B., University of Missouri—St. Louis, Missouri Mann, Kristi Marie, St. Louis TT University—Kankakee, Illinois 14X L

Million, Suzanne Webb, B.S., L Vanderbilt University, '80—St. Louis, Missouri Modica, Mary Ellen, University of Illinois—Berwyn, Illinois Nuessen, Julie, Iowa State University—Quincy, Illinois Phillips, Margaret Louise, B.S., Western Kentucky University, 79— Nashville, Tennessee Russell, Jennifer Marguerite, University of Pittsburgh— Murrysville, Pennsylvania Ruzensky, Catherine Mary, Washington University—Florissant, Missouri Schulte, Leah Marie, Washington University—Marthasville, Missouri Schwab, Lynn Annette, Washington University—Palatine. Illinois Smith, Kendra Kay, B.S., Southern Illinois University, '80—West Frankfort. Illinois Weis, Jennifer Joanice, University of Colorado—Englewood, Colorado Weismann, Joyce Ann, PROGRAM IN Lawler, Ann Louise, B.S., Washington Meramec Community College— OCCUPATIONAL University. '81—St. Louis, Missouri St. Louis, Missouri THERAPY Lewis, Terry Lynn, B.A.. Ohio Wenzel, Barbara K., Belleville Area State University. 78—New Graduate Class 1981-82 College—Belleville, Illinois Philadelphia, Ohio Bowman, O. Jayne, B.A., Baylor Wiley, Valla Denise, Forest Park Junior Mallonee, Nancy Lee, B.S., St. Louis College. '58—Belton, Texas, B.S., College—St. Louis, Missouri University, '63—St. Louis, Missouri University of Wisconsin, 73—Madison, Wolfe, Eileen Owens, West Virginia Wisconsin Mendelson, Mary Lavis, B.S.. University—Edgewater, Maryland Washington University, '53— Buckley, Margaret Mary, B.A., St. St. Louis. Missouri Woodcock, Edith J., B.A., Macalester Louis University—St. Louis, Missouri College, 76—St. Louis, Missouri Miller, Kathleen Anne, B.S., Ohio State Burson, Katherine Ann, B.S.. University, 78—Macomb. Illinois Yip, Ivy, Sacramento City College— Washington University, "81—St. Louis, Kowloon, Hong Kong Missouri Montoya, Tamar Anette, B.A.. North Junior Class 1981-82 Dakota State University, 75; B.S.. Cantieri, Annette Elaine, B.S., University of North Dakota, 77— Debra Anderson Diane Ratigan University of Wisconsin, 78—LaCrosse, Fargo. North Dakota Jo Ann Benjamin David Selig Wisconsin Mueller, Cynthia Haffner, B.S., Mary C. Berry John Shrake DuBuske, Susan Greboski, B.S., 1 Raymond Bullerdiek Kathy Shymkus Fontbonne College, 76— University of Illinois, 78— St. Louis, Missouri L Elsie Burger Connie Stewart Chicago, Illinois Danny Edwards Ellen Warner Overhuls, Pamela, B.S.. University of Erwin, S. Ellen, B.S.. Texas Woman's Deborah Edwards Jacki West Oklahoma, 77—Norman. Oklahoma University, 75—St. Louis. Missouri Sheryl Gilbertson Marilyn Whetzel Pennington, Dorothy Johnson, B.A., Robin Hess Fletcher, Catherine Spademan, University of Mississippi, '65— Sharon Hollowell B.A., Newcomb College. 70— St. Louis, Missouri Boulder, Colorado Jody Jacobson Prins, Steven Scott, B.S.. Grand Valley Jacqueline Just Franz, Jane Renee, B.S., University of State College. 76—Zeeland. Michigan Sue Kohn Missouri, 70—Columbia. Missouri Rankin, Cathy Ann, B.S., Tufts Barbara Lemmel Hegberg, Anne Marie Phillips, B.A., University. 78—Manchester, Maine Barbara Leveling a Valparaiso University, 79—Wheaton. Stemmler, Loren JoAnn, B.S., Teresa Lindquist Illinois c i Scott McLaughlin Fontbonne College, 79— Connie McMath Kalscheur, Jean Ann, B.S., University of St. Louis, Missouri Wendy Magee Wisconsin, Madison, 74— Velozo, Craig Antonio, B.A., College of Thomas Mayhew Middleton, Wisconsin the Holy Cross, 77—Worcester, Susan Musselman Koziol, Catherine Mary, B.A.. Massachusetts Joan Pease Rockhurst College, 76— Yang, Min-Ian, B.S., National Taiwan Karla Plantz Chicago, Illinois University, 77—Taipei, Taiwan

149 Senior Class 1981-82 Knopp, Carol Ann, St. Louis Powers, Kathleen Marie, Benedictine Class, Nancy Anita, Maryvillc College - University—St. Louis, Missouri College—St. Louis, Missouri Manchester. Missouri Levine, Jill Faith, Washington Rosenberg, Candra Dee, Washington Cole, Douglas Mayo, Washington University—Hewlett, New York University—Belleville. Illinois University—Miami, Florida Lhamon, Lisa Hampp, Ross, Karyn M., Grinnell College— Coyne, Nancy Nelson, University of Missouri, St. Louis— St. Louis, Missouri Washington State University— St. Charles, Missouri Swanson, Debra Lynn, Washington Edmonds, Washington McPherson, Cheryl Lynn Ellison, University—Alma, Nebraska Fishman, Selma Ann, University of Washington University—Bridgeton, Traina, Anna Marie, Illinois—Peoria, Illinois Missouri University of Missouri, Columbia— Gaj, Cheryl Lynn, California State Merlo, Joan Marie, Southeast Missouri St. Louis, Missouri University, Northridge—North State University—St. Louis, Missouri Troeder, Elizabeth Gail, Washington Hollywood, California Merrill. Margaret Ruth, Colorado University—New Rochelle, New York Gawlik, .InAnn Marie, University of College—Freidheim. Missouri Weaver, Pamela Joan Dischner, Florida —Bensenville, Illinois Nemergut, Laurie Beth, Valparaiso Nebraska Wesleyan University— Holle, Kim Diane, Indiana University- University—Portage, Indiana Lincoln. Nebraska New Haven, Indiana Paradise, Kraig David, Florissant Wiegert, Lynn Elizabeth, Southeast Kim, Deborah Elaine, Washington Valley Community College— Missouri State University— University—Honolulu, Hawaii St. Louis. Missouri St. Louis, Missouri Knapp, Linda Rose, University of Illinois—Columbia. Illinois

IS THERE LIFE AFTER MED SCHOOL?

150 L Arribas, Neva P., 67 Benedict, William W., 53 Staff Index Arthur, R. Martin, 108, 120 Benham, Lee, 89 Atkinson, John P., 48, 57 Bennett, Kathryn G., 93 Abbey, Elliot E., 52 Auer, Arthur I., 104 Bennett, Kenneth J., 103 Abboud, Nabil, 35 Auguste, Jean M., 80 Benoist, Walter F, 80 Abdel-Bari, Wagih M, 74 Aune, Thomas M., 74 Berg, Douglas E., 41,57 Abel, Charles C, 50 Avioli, Louis V., 47 Berg, Edward F., 67 Abel, Oliver, 111. 51 Ayata, Sedat M., 36 Berg, Leonard, 59 Abichandani, Lachman K., 93 Berger, Edward J., 89 Abrams, Morris, 105 Baenziger, Jacques U., 73 Berger, Louetta, 95 Abramson, Charles L., 98 Baenziger, Nancy L., 50 Berger, Nathan A., 48 Abrath, Frederick G., 98 Baer, Jill M., 81 Berger, Sosamma J., 83 ] Abruzzini, Linda N.K.F., 54 Bagby, James W., 48 Bergman, Martin, 102 Ackcrman, Joseph J. H., 50 Baglan, Robert J., 98 Bergmann, John F., 92 Ackerman, Lauren V., 72 Bahl, Om.P., 51 Bergmann, Steven R., 49 Ackerman, Marilyn J.B., 54 Baker, Marion H., 81, 109 Bergner, Grace E., 51 ] Adler, Benard C, 69 Balasubramanian, T. M., 85 Berkowitz, Wallace P., 69 Aff, Helen M., 79 Baldassare, Joseph J., 39 Berman, William, 64 Agrawal, Harish C, 59, 73. 78 Balfe, Dennis M., 98 Berry, John W., 51 Agress, Harry, 52 Ballinger, Walter F, 102 Bhanot, Pardeep, 81 ] Ahmed, Parveen, 74 Banaszak, Leonard J., 38, 85 Bhatt, Dushyant N., 36 Ahumada, Gail A., 49 Barcus, Susan H., 105 Biello, Daniel R., 97 Aitken, Diane L., 126 Bardsley, John L., 98 Bier, Dennis M., 49, 79 Aitken, Louis F., 52 Barenkamp, Stephen, 79 Bieri, Michael D., 92 1 Albert, Ingrid R., 52 Barker, Edward T, 80 Biggs, F. Douglas, 53 Albert, Stephen F., 99 Barnes, Wayne M., 39 Biggs, John T, Jr., 91 Alegre, Jorge M., 52 Barr, Susan, 125 Bilchik, Ronald C, 67 Aleksander, Bernardo G., 92 Barrett, Scott R., Jr., 65 Binder, Morton, A., 48 ] Alex, Morris, 51 Barrett, Scott, Sr., 65 Birenbaum, Aaron, 53 Alexander, France, 51 Barrow, Jack, 48 Birge, Claire H., 52 Alias, Susy, 89 Barry, C. David, 85 Birge, Clifford A., 51 Allen, Hubert L., 65 Bartley, Margaret, 127 Birge, Stanley J., Jr., 48 ] Allen, Thomas W., 50 Barton, Robert W., 51 Birktoft, Jens J., 39 Allen, Willard M., 64 Basile, Mary Beth, 125 Bischoff, E. Richard, 34 Alpers, David H., 47 Bassman, Donald R., 104 Bisno, Daniel, 67 Alvis, Edmund B., 67 Battes, Norma J., 127 Bitz, Donald M., 124 1 Ambos, Hans D., 52 Bauer, Eugene A., 48 Black, Joseph T, 60 Amin, Nevinkumar J., 67 Bauer, John D., 74 Blaine, G. James, 111, 108 Anderson, Charles B., 102 Bauer, Joseph A., 80 Blair, Vilray P., Jr., 104 Anderson, John M., 91 Bauer, Spomenko, 36 Blamovillc, HuldahC, 81 ] Angelo, Elaine, 125 Bauer, Walter C, 72, 110 Blethen, Sandra L., 79 Anscheutz, Robert R., 103 Baum, Barbara, 125 Bloomberg, Gordon R., 80 Anthony, E. James, 95 Baumer, Susan L., 81 Bobrow, James C, 67 Antoniou, Christos A., 80 Bauschard, Frederick D., 53 Bohigian, George M., 67 ] Antonocci, Diane, 125 Bauwens, Daniel B., 53 Bohne, Barbara A., 69 Apirion, David, 57 Beale, Mary G., 79 Boime, Irving, 64, 83 Apprill, Jolene, 125 Beamer, M. Susan, 124 Boles, C. Read, 79 Aquino, Tomas, 74 Beare, J. Byron, 106 Bond, Leslie F, 104 ] Araneo, Barbara A., 74 Becker, Bernard, 66 Boniuk, Isaac, 67 Arbo, David A., 126 Becker, Robert L., 65 Bonskowski, Cynthia, 127 Ardekani, Ahmad, 93 Becker, Stanley C, 67 Boonshaft, Benje, 51 Arias, Fernando, 64 Bedwinek, John M., 98 Borowsky, Benjamin A., 51 I Arneson, A. Norman, 64, 98 Beetham, Karen L., 99 Bortnick, Arthur R., 64 Arnold, Kenneth J., 103 Belen, Marietta O., 81 Boswell, Dee C, 53 Arnot, John R, 105 Belew, Joe E., 65 Bowen, Ted, 122 Arnzen, Robert J., 108 Bell, C. Elliott, Jr., 48, 73 Bowen, William G., 51 1 Aronberg, Dixie J., 98 Bell, Martin J., 79, 105 Bower, Richard J., 79, 105 Aronberg, Jerome M., 53 Bell, Robert M., 92 Bowles, William T., 105 Aronberg, Lawrence M., 106 Bello-Reuss, Elsa, 49, 85 Boxerman, Stuart B., 120, 122

I 151

. hL I Boyarsky, Rose, 106 Canedy, James A., 122 Cohen. Edward, 99 Boyarsky, Saul, 105, 120 Cannady, Edward W.. 52 Cohen, Frank, 53 f Braciale. Thomas J.. 73 Caplin, David A., 105 Cohen, Leonard, 54 Braciale, Vivian, 74 Carey. Gregory, 92 Cohen, Randolph. D., 52 J Bradley, Anna K., 93 Carl, Juanita L., 93 Cohen, Robert S., 64 Bradley, Richard V., 103 Carlin, M. Richard, 105 Cohn, Dunell E., 54 Bradshaw, Ralph A., 38 Carlson, Mary L., 92 Cole, Barbara R.. 79 Brajtburg, Janina M., 50 Carmody, Sharon E., 54 Coleman, Carole L., 126 Brancato, Donald H., 104 Carney, Robert M., 92 Collins, Robert C, 60 s Brandwin. Leslie M., 53 Carr, Charles D., 69 Comegys, Thomas H., 69 L Brennan. Ruth E., 89 Carroll, James E., 60, 79, 111 Comens, Philip, 53 Brett, AllanS., 51, 109 Cary, John M.. 53 Cone, Alfred J., 69 J Bricker, Eugene M., 103 Catalona, William J., 105 Connors, John P., 102 Bridwell, Christine O.. 125 Catanzaro, Francis J.. 51 Conrad, Marshall B., 104 Brinkman. Robert A., 53 Chan, Kwok-Ming, 49, 73 Cooper, Dorothy G., 67 Britton, Carmelita V.. 81 Chang, Katherine, 74 Cooper, Thomas W.. 52 Brodeur. Garrett M.. 79 Chaplin, Hugh, Jr.. 47, 88 Copp, Ralph. Jr.. 53 Brodzinski, Catherine C, 125 Charles. Benjamin H.. 52 Cordes, Donald W., 122 Broering, Jeanette M., 81, 109 Chasalow, Fred I., 79 Cori. Carl F, 38 Brooke, Michael H.. 59, 88. Ill Chase, Howard M„ 123 Cornbleet, Suzanne, 125 Brookes, Robert D., 92 Chase, Lewis R., 48 Corr, Peter B., 49, 83 [ Brooks, Jeffrey S.. 53 Chen, Dien-ming Ben. 98 Corry. James M., 80 Brown. Barbara I., 38 Chen, May W-S, 89 Corvalan, Juan C, 92 L Brown, David H., 38 Cheng, Chuan Huan, 60 Costello, Cyril J., 103 Brown, Elmer B., Jr.. 47 Cheung, Laurence, 103 Costello, John B.. 54 T Brown, Miner L., 123 Cheung, Sau Wai, 64 Costen, William S., 104 Brown, Richard W., 123 Chi, David Yuen-Kai, 60 Coulter, Dean M., 99 Brownstone, Jane E., 92 Chieffi, Margaret, 53 Courtney, John, 57 Broze, George J., Jr.. 49 Childers, Jean E., 104 Covey, Douglas F, 83 Bruce. Robert M.. 51 Chilson, Oscar R, 38 Covey, Thomas H., Jr., 103 Bryan. James H., 67 Chin, Chang-chen, 64 Cox, Jerome R., Jr., 85, 108, 120 Bryan. Marion P.. 69 Chirgwin, John M., 34 Cox, Mary E., 92 Bryan, William T. K., 69 Cho, Kyu Sop, 105 Coxe, WilliamS., 61, 110 Bryant. L. Gerald, 123 Choi, Sei Y., 92 Cozart, Duane E., 53 Bucy, James G., 105 Chojecki, Lawrence F, 125 Crafford, William A., Jr., 52 L Budenstein. Mary Jane, 122 Chraplyvy. Maria, 74 Crane, James P., 64 Buerkert. John E., 49 Christie, Barbara, 127 Crawford, Charles E., Jr., 81 1 Buettner, John B., 103 Christlieb. Ignacio. 102 Crawford, Katherine. 104 Bunge, Mary B., 34 Christopherson, Howard L., 54 Crespin, Stephen R., 51 Bunge, Richard R, 34 Chunduri, Krishna, 36 Crimi, Felipe, 93 Burch. Helen B., 83 Chyn, Frieda R., 54 Criscione, James R., 104 Burde, Ronald M.. 59. 61,66 Cicero, Theodore J., 34, 91 Croughan, Jack L., 91 Burgdorf. Max H., Jr.. 79. 109 Clapper, Mary P., 126 Cryer, Philip E., 47 Burgess, Dean B., 67 Clare, Margaret H.. 59 Cubillo, Enrique, 98 Burgess, Kate, 127 Clark, Howard Brent, 74 Cullen, Susan E., 41, 57 Burns, Karen, 125 Clark. Joan G.. 49 Cutler, Harold M., 68 Burstein, Robert, 64 Clark, Kenneth W., 108 Burton, Harold, 34, 85 Clark, Richard E., 102, 120 Dahlgren, Robert R., 74 Burtram, Sarah G., 123 Clark. William, 69 Dalton, Arthur R., 103 Busch, Suzanne G.. 80 Clendenin. William W., 92 Danforth, William H., 47 Butcher, Harvey R.. Jr., 103. 110 Clifford. David B.. 60 Daniels, John S., 51 Clingman. Arthurline, 123 Dankner, Arnold, 48 Cain. Michael E..49 Cloninger, C. Robert, 41, 91 Danziger, Warren L., 60 Calodney. Martin, 80 Clouse, Ray E., 52 Dargar, Ratna V., 89 Calvin, Lincoln B.. 92 Clutter, William E., 49 Datuin, Alejandro M., 93 L Camel. Greta. 52 Co, Bun Tee, Jr., 92 Daughaday, Carlos C, 49 Camel. H. Marvin, 64, 110 Cobb, Milton L.. 35. 79 Daughaday, William H., 47 I Campbell, Edward J., 49 Coben, Lawrence A., 60 Daum. Wayne .1., 104 Canaan. Samuel A., Jr., 67 Cohen, Adolph I.. 34, 66 Daussman. Winnie, 127 152 CJ Davenport. Debby, 125 Eades, Joseph W„ 105 Fisher. Gail. 125 Davidson, John D., 51 Eagleton, Mark D„ Jr., 98 Fisher, Linda A., 53 Davidson. Morris, 68 Earls, Felton J., 80, 95 Fishman, Norman, 53 Davie, Joseph M.. 57, 72 Eaton, Royal J., 53 Fisk, David E.. 53 Davis. Gene L., Jr., 99 Ebling. Fanny M., 54 Fiance. I. J.. 48 Davis, Hollowell, 68, 85 Edelstein, Gerald, 99 Fleischman, Julian B., 57 Davis. Mary. 92 Edmond. Beauvoir H.. 99 Fleishman, Alfred, 52 Davis. Sheldon L., 69 Edwards. Isaac A., 61 Fletcher. Anthony P., 48 Daw, Nigel W., 66, 85 Edwards. Joseph C, 50 Fletcher, Norma A., 48 Dean, Raymond S., 92 Eggebrecht, Russell, E., 53 Florence, Julaine. 60 Debnam, James W., Jr., 98 Ehrlich, Carl F. 69 Flynn, Charlene M., 125 Deitchman, Robert B.. 91 Ehsani, Ali A., 48, 89. Ill Ford. Branka F. 53 Delfino, John J., 105 Eichling, John O., 97 Ford. Lee T„ 104 Delitto. Anthony, 125 Eisen, Arthur Z., 47 Forsyth, B. Todd. 53 Delmez, James A., 49 Eisen, Seth A., 49 Fourqurean, Thomas W., 123 Del Rosario, Luis Q., 74 Eldridge, Donald H.. 68 Fox, Seymour, 99 deMarchena. Octavio, 60 Eliasson, Sven G.. 59. Ill, 125 Frank, Robert E„ 122 deMello, Vincent R., 51 Eller, C. Howe. 88 Frazier. Wiliam A., 34, 39 DeMott, John, 69 Ellis, Patricia M.. 125 Freedman, Ruth S., 67 Denes. Alexander E., 51 Ellsasser, James C, 104 Freeman, David M., 67 DeSchryver, Katherine, 73 El-Mofty, Samir K., 73 Freiman. S. Michael. 64 Destouet, Judy M., 98 Elson, Elliot L.. 38 Freund. Samuel J., 103 Detrick, Paul F., 123 Emami, Bahman. 98 Frieden, Carl, 38 Deuel, Ruthmary K., 60, 79 Engebretson. A. Maynard, 108 Friedman, Ira J., 80 Deuel, Thomas F., 38, 47 Engelhardt, Robert C, 36 Friedman, Paul L., 36 Deusinger, Robert H., 124 Erlacker, Frances L., 125 Friedman, Robert H., 79 Deusinger, Susan, 125 Erlanger, Margaret W., 54 Friedrich, Ernst R., 64 Deutch, Max, 79 Escoffery, Richard F., 67 Frishberg, Tamara, 93 Dew, Thomas A., 53 Esslinger, Arthur T., 64 Fry, Robert D., 103 De Weer, Paul J.. 85 Etheredge, Edward E., 103 Fryer, Minot P., 105 Deza, Plaridel C, 92 Evelhoch, Jeffrey L., 54 Fukami, Yasushi, 85 Diaz, Armand, 99, 130 Evens, Ronald G., 97 Fukui, Kiyoshi, 54 Dickler, Donald J., 36 Fuller, Philip S. B., 53 Dickoff, Steve, 125 Fabian, Leonard W., 35 Fuller, Terry A., 92 Dierks, Bill, 125 Fair, William R.. 105 Fulling, Keith, 73 Dietzler, David N., 48, 73 Fallon, Richard H., 103 Distelhorst, Clark W., 79 Farberman, Susann M., 81 Gado, Mokhtar, 61.97 Dobbs, Larry, 69 Faw, Kenneth D., 69, 80 Galakatos. Andrew, 64 Dodge, Philip R„ 59, 78 Feibel, Robert M., 67 Gale, Arthur H., 51 Dodson, Sandra J., 81 Feigenbaum, Bernard. 89, 122 Gall, Ira C. 65 Dodson, W. Edwin, 60, 79 Feldman, David, 53 Gallagher, William J., 36 Donaldson, Robert C, 103 Felling, Carl J., 123 Galster. Allen D., 52 Donati. Robert M., 47 Felts, James A., 35 Gans, Lawrence A., 67 Dooley, Joseph M., Jr., 60 Ferguson, Thomas B., 102 Garcia, Florentina U.. 81 Dougherty, Charles. H., 80 Ferrendelli, James A., 59, 83 Gardner. Richard A„ 120 Dowell, George H., Jr., 92 Ficke, David C, 99 Gardner, Tessa D., 80 Drews, Robert C, 66 Fierstein, Jeffrey T., 69 Garfinkel. Bernard T, 48 Drey, Norman W., 52 Fiete, Dorothy J., 74 Garrett, Jerry, 123 Druck, Norman S., 69 Fine, Susan B.. 127 Garrett, John J., 48, 109 Drysdale, George R., 38 Fingert, Hyman H., 92 Garrity, Kathleen. 126 Dude, Camilla J., 125 Fink, C. Joan, 74 Gaskin, Fred W., 92 Duemler, Robert H., 65 Finke. Edward H., 74 Gaskin, Ronald J., 103 Duling. Gerald J.. 80 Finney, Robert D., 123 Gast, Michael J., 64 Dumadag, Virgilio P., 74 Fischbach. Gerald D.. 34 Gaum, Leonard D., 105 Dumlao, Rodolfo, 67 Fischbein. Lewis C, 51 Gaus, Ellen, 126 Dunham, James G., 108 Fischer, Keith C, 98 Gavin, James R., Ill, 49 Dwivedy, Mary S., 126 Fish, Virgil O., 103 Gayer, Mark J., 125 Dy, Pacita C, 94 Fishbein. Morris D., 93 Gearhart, Wilbur H., 92 Dykhuizen. Daniel E., 41 Fisher. Edwin B., Jr., 50 Gebel. Howard M., 49, 73

153 Gee, David A., 122 Grand, M. Gilbert, 67 Harper, Fleming B., 103 Geisse, Guillermo C, 98 Granoff, Alice B., 80 Harris, Foster, 54 Gelb, Lawrence D., 48, 57 Granoff, Dan M., 79 Harrison, Lee B., 52 Geller, David M., 83 Grant, Gregory A., 39, 50 Harrison, Stanley L., 79 Gellman, Elliot F., 80 Grant, John M., 51 Hart, William M., Jr., 66 Geltman, Edward M, 49, 98 Grant, Neville, 48 Harter, Herschel R., 48 Gentsch, Kenneth W., 53 Grant, Samuel B.. 50 Hartl, Daniel L., 41 Germuth, Frederick G., Jr., 73 Graves, Fredrick J., 123 Hartman, Boyd K., 34, 91 Gerscll, Deborah, 73 Greenman. Marshall B., 79 Hartmann, Alexis F, Jr., 78 Giddings, Stephen J., 49 Gregory, Walter T., 54 Hartnett, Anna E., 95 Gieselman, Ralph V., 48 Greider, Marie H., 73 Hartroft, Phyllis M., 73 Gildea, Margaret C. L., 91 Gribbins, Ronald E., 122 Hartstein, Jack, 67 Gilden, Jerome J., 104 Griffin, Marilyn S., 126 Harvey, James D., 122 Gilson, Arthur S., Jr., 85 Griffith, Rogers C., 73 Harvey, Joseph E., 69 Gilster, John, 80 Grisham, H. Richard, 123 Harwell, J. Larry, 80 Gilula, Louis A., 97 Grodzki, Walter J., 67 Hatlelid, John Michael, 60 Gingerich, Ronald L., 52, 80 Gronau, Axel R., 52 Hauptfeld, Miroslav, 41 Ginsburg, Jordon H., 104 Groner, Frank S., 122 Hauptfeld, Vera, 41 Gisel, Erika G., 127 Grubb, Robert L., Jr.. 61,97 Hayes, Barbara, 125 Glaser, Luis, 38 Guebert, Elvera C., 125 Hays, Howard L., 123 Glasgow, Glen P., 98 Gulick, C. Richard, 64 Hazan, Joseph, 65 Glazer, Harvey S., 99 Gulick, Charles R., 64 Headley, Barbara, 126 Glogovac, S. Vic, 105 Gulmen, Guner B., 49, 109 Heffern, Libby, 127 Goell, Robert S„ 64 Gulmen, Suleyman, 73 Heiken, Jay P., 99 Gohagan, John K.. 89 Gupta, Jitendra K., 53 Heins, James N., 48 Goldberg, Andrew P., 49, 89 Gupta, Santosh, 80 Helfrien, Betty, 125 Goldberg, Anne C., 52 Gutierrez, Fernando R., 98 Heller, Randall L., Jr., 65 Golden, Stuart A., 61 Gutwein, Michael B., 109 Hellman, Robert, 36 Goldenberg, Carlos J., 73 Guze, Samuel B., 48, 91 Helzer, John E., 91 Goldfarb, Alvin, 103 Hembree, Judy, 125 Goldman, Arnold M.. 53 Habecker, Paula, 127 Henneke, Diedra, 125 Goldman, Melvin L..51 Hack, Stanley N., 126 Hennelly, Virginia D., 122 Goldring, David, 78 Haddock, James N., 92 Henry, Philip D., 48 Goldring, Sidney. 59. 60 Haffner, Heinz, 103 Hepner, James O., 122 Goldstein, Benjamin M.. 51 Hagberg, James M„ 89 Herjanic, Barbara M., 79, 95 Goldstein, Milton N., 34, 73 Hagemann, Paul O., 48 Herjanic, Marijan, 91 Gollub, Samuel W., 80 Hagen, Ronald W., 108 Hernandez, Antonio, Jr., 79 Gondipalli, N. R., 36 Hahm, Kyung-Soo, 89 Herron, Anne, 53 Gonen, Boas, 49, 89 Hahn, Bevra H., 48 Herscovitch, Peter, 60 Gonzalez, Alicia D., 95 Hahn, Theodore J., Jr., 48 Hcrshcy, Falls B., 103 Goodenough, Ursula W., 34 Haines, Jay W., 103 Hertel, Ronald C, 104 Goodwin, Phillip H., 123 Hall, Julian C, 92 Herweg, John C, 78 Goran, David A., 53 Hall, William K., 51 Herzig, Geoffrey P., 48 Gordon, James M., 67 Halverson, John D., 103 Herzog, Godofredo M., 65 Gordon, Jeffrey I., 49 Hamant, Celestine, 127 Hesker, Albert E., 98 Gordon, Mae E., 67 Hamilton, D. Jane, 52 Heston, Warren D., 105 Gorman, Ira, 125 Hamilton, John A., 65 Heuser, John E., 85 Gottesman, Irving L, 41, 91 Hammer. Randy L., 94 Hickman, Scot G., 49 Gottlieb, Charlene C., 34 Hammerman, Albert M., 99 Hickok, Robert J., 122, 124 Gottlieb, David L, 34, 39 Hammerman, Marc R., 49 Hicks, Robert S., 92 Gourley, Janet N„ 125 Hammes, Roman E., 81 Hieb, Barry R., 50 Gowda, Siddhesh, 51 Hammond. David T., 51 Hildreth, Howard R., 67 Grabau, Gene H., 79 Hampton, Stanley F, 48 Hill, Rexford L., 97, 108 [1 Grace, Ann M., 54 Hanaway, Joseph, 60 Hillman, Laura S., 79 Grady, La Verne W., 127 Hanish, Sidney J., 67 Hillman, Richard E., 41, 78 Grady, Ronald K... 53 Haralson, Kathleen M., 125 Hinderer, Harold, 123 Graff, Barry A., 36 Hardin, William B., 60 Hinkley, William E., 53 Graff, Ralph J., 41, 103 Hardy, Guerdan, 69 Hinrichsen, Jeannette, 125 Grambow. Linda, 125 Harford, Carl G., 47, 109 Hipps, Paul P., 92

154 Hirokawa, Nobutaka, 85 Jackson, Craig M„ 38, 48 Kaufman, Robert L., 51 Hirsch, John D., 103 Jackson, Darwin C, 65 Kayes, Jack, 67 Hirsh, Ira J., 68 Jacobs, Charles C, 69 Keating, James P., 78 Hirshberg, Gary E., 36, 80 Jacobs, Frederick A., 79 Keating, Susan K., 81 Hitchens, Richard E., 108 Jacobs, Myron H., 53 Keim, Catherine R., 54 Hitt, David H., 122 Jacques, Clemens H., 67, 109 Keller, David W., 64 Hixon, Barbara B., 89 Jaffe, Allan S., 49 Keller, Kathleen M., 125 Hobbs, John E., 64 Jakschik, Sr. Barbara A., 83 Keller, Maurice J., 79 Hodges, Fred J., Ill, 97 Janes, Cynthia L., 95 Kelly, John J., 51 Hoecker, Jay L., 81 Janes, Norma J., 52 Kempe, Joseph C, Jr., 127 Hoffman, Gary R„ 99 Jaudon, Joseph C, 79 Kennell, David E., 57 Hoffman, Pamela, 125 Jean, J. Ted, 52 Kessel, James W., 65 Holcomb, William L., 65, 109 Jeffrey, John J., Jr., 39, 47 Kessler, Gerald. 73 Holder, Barrett K., 104 Jenkins, Erna C, 95 Kessler, Sheldon, 81 Holemon, R. Eugene, 92 Jenkins, James J., 36 Kheim, Teofil, 52 Holland, William H„ 39, 92 Jenny, Arthur B., II, 61 Kilboum, Michael R., 98 Holloszy, John O., 49, 88 Jesse, Major Norris, 125 Kilo, Charles, 49 Holloway, Robert B., 36 Jick, Sidney, 51 Kim, Duck O., 85 Holmberg, Nels J., 67 Joffe, William S., 67 Kim, Kwangsup S., 52, 109 Holmes, Nancy E., 81 Joftus, Morris, 53 King, A. Donna, 89, 109 Holmes, William F., 39, 108, 122 Johnson, Eugene M., Jr., 83 King, Donald K., 49, 109 Holt, Earl P., Jr., 104 Johnson, George B., 41 King, M. Kenton, 47, 88 Holtmann, Barbel, 80, 105 Johnson, Jerry A., 127 Kingsbury, Robert J., 103 Holtz, Sumner, 98 Johnson, Mary I., 34, 60, 80 Kingsland, Robert C, 51 Holzum, Helen Marie, 125 Johnson, Michael K., 65 Kipnis, David M., 47 Hong, Barry A., 92 Johnston, Glen P., 67 Kissane, John M„ 72, 78 Hookerman, Bruce J., 53 Johnson-Masters, Virginia, 94 Kissel, John H., 51 Hoorman, Martha L., 126 Jones, Andrew B., 66 Kiyanclar, M. Emin, 36, 80 Hope, William B., Jr., 123 Jones, Dorothy J., 79, 81 Klahr, Saulo, 47 Hopper, Susan V, 52 Jones, Edward G., 34, 59, 61 Kleiger, Robert E., 47 Horner, John L., 53 Jones, Gary L., 53 Klein, Jacob, 64 Horsh, Donald J., 122 Jones, James D., II, 35, 64 Klein, Saul, 106 House, Roy C., 122 Jones, Larry A., 81 Klingele, Terence G., 67 Houtz, Duane T., 123 Jones, Sara T, 36 Knesevich, John W., 92 Howard, Thomas, ST., 54 Jonsson, Valgard, 74 Knight, Alfred B., 64 Howell, Mabel P., 123 Joseph, Harold J., 48 Knock, Henry L., 80 Hoy, Janet D., 109 Jost, Ellen, 125 Knopf, Harry L., 67 Hruska, Keith A., 49 Jost, R. Gilbert, 97 Knowlton, Norman P., Jr., 51 Hsieh, Kun-hwa, 74 Juergens, William G., Jr., 51 Knudson, Carol, 125 Huang, Henry V., 57 Kobayashi, George S., 47, 57 1 Huang, Jung S., 50 Kadmon, Dov, 106 Kodner, Ira J., 103 Hubert, John W., 53 Kahn, Lawrence I., 78, 88, 109 Koerner, Kenneth A., 79 Huck, Richard F, 53 Kahn, Richard A., 74 Kolker, Allan E., 66 Hudgens, Richard W., 91 Kaiser, Kenneth K., 60 Kolodny, Robert C, 53, 94 n Huebener, Donald V., 80, 98 Kaiser, Ronna S., 125 Koob, Patricia A., 126 Hughes, Charles P., 60 Kakita, Keiji, 54 Kopen, Dan F, 104 Hulbert, Bernard, 51 Kannegieter, Ruthan B., 127 Kopman, A. Ercument, 35 Humphreys, James B., 123 Kantor, Owen S., 48 Korenblat, Philip E., 49 Hunt, Carlton C., 85 Kao, Ming-Shian, 64, 110 Kornfeld, Rosalind H., 38, 47 Hunter, F Edmund, Jr., 83 Kapadia, Milan D., 54 Kornfeld, Stuart A., 38, 47, 110 Hussain, Abid, 94 Kaplan, Alex H., 91 Kotner, Lawrence M., Jr., 99 Hutchinson, James H., Jr., 51 Kapp-Pierce, Judith A., 57, 73 Kovac, S. Robert, 65 Kardos, John L., 120 Kowert, Edward H., 91 Karl, Irene E., 47 Kraetsch, Robert E., 53 lngber, Carl S., 81 Karl, Michael M.,48 Kraft, Gerald, 125 Ingram, Donald R., 69 Karr, Robert W., 52 Krajcovic, David, 103 Inukai, Joseph, 60, 61 Karsh, Robert S., 49 Kraner, Justin F, 65 Isserman, Michael J., 67 Kass, Michael A., 66 Kraus, Frederick T, 73 Isserman, Michelle, 127 Katzenstein, Anna-Luise, 73 Krause, G. Lynn, Jr., 103

155 Krechel, Susan W., 36 Levitt, Robert G., 97 Mannis, Charles, 104 Krogstad, Donald J., 49, 73 Levy, Jerome F., 103 Mansfield, Edgar O., 123 Kronberger, Annemarie, 54 Levy, Morton A., 51 Manske, Paul R., 105 Krone. Ronald, 48 Levy, Richard A., 52 Marban, Manuel, 74 Kronemer, Norton S., 81 Lewis, Collins E., 92 Marbarger, John P., 102 Krupin, Theodore, 66 Lewis, Joyce K., 126 Marcus, Daniel C, 69 Kuczer, Arnoldo, 69 Liang, Duan, 99 Marcus, Morris D., 48 Kuhlman, Ralph F., 51 Lickhalter, Merlin E., 123 Marcus, Nancy. 69 Kuhlman, Robert E., 104 Lieberman, David M., 48, 49 Marcus, Robert H., 52 Kuhn, Charles, 72 Lieberman, Michael W., 72 Margolis, David M., 53 Kulczycki, Anthony, Jr., 49. 57 Liebhaber, Despine, 81 Margolis, Richard, 80 Kulkami, Shrikrishna. 93 Liebhaber, Harvey, 49 Margraf, Harry, 103 Kuman, Ravi S., 36 Liedloff, Mary, 125 Mariz, Ida K., 50 Kumar, Bharath A. K., 98 Ligman. Judy, 125 Markell, Joann, 125 Kumar, Buddhiraju V., 50 Lilly, Douglas R., 51 Markensen. Kathy, 125 Kurz, Linda C, 39 Lin, Hsiu-san, 57, 97 Markham, Richard B.. 50, 57 Kusama, Haruo, 95 Linberg, John V., 67 Marks, James E., 97 Kusama, Susan M., 127 Lindstem, Janet, 125 Marsh, Jeffrey L., 80, 105 Kuttner, Marianne. 80 Lins, Robert D., 81 Marshall, Garland R„ 38, 85 Kuxhaus, Mary K., 127 Lipsitz, Ellis S., 53 Marshall, Jay P., II, 51 Kyriakos, Michael, 72 Lischer, Carl E., 103 Marshall, Richard E., 78 Liss, Jay L., 93 Martin, J. Barlow, 64 Lacy, Paul E.. 72 Little, J. Russell, Jr., 47, 57 Martin, Jeanne E., 83 Ladd, Joanne, 125 Little, Katherine D., 54 Martin, Kevin J., 50 Ladenson, Jack H., 49, 73 Littlefield, Charleyne B., 126 Martin, Philip L., 69 Lake, Jeffrey P., 74 Loeb, Virgil, Jr., 48 Martin, Sandra, 125 Lake, Lorraine F., 124 Loewy, Arthur D., 34 Martin, Thomas F, 51 Lake, Sandra A., 125 Logie, MacDonald B., 98 Martin, William Robert Wayne, 60 Lakshminarayanan, Natarajan, 93 Londe, Alan M., 103 Martz, John C, 79 Lamb, Wanda M.,91 Londe, Sol, 79 Maslanko, Jerald, 53, 109 Lamberg, Robert L., 67 London, Stanley L., 103 Mason, Norbert S., 120 Land, Vita J„ 79 Lonergan. Warren M., 51 Massey, J. Stevadson, 61 Landau, William M., 59 Long, Frank B., Jr., 64 Massie, Edward, 48 Lander, Jerrold J., 51 Lonsway, Maurice J., Jr., 79 Masters, William H., 64, 94 Lander, Robert C, 104 Lothman, Eric William, 60 Mathews, F. Scott, 38, 85 Landt, Michael L., 73, 80 Lottes, J. Otto, 104 Mathis, Larry L., 123 Lane, Clinton W., 47 Low, Robert L., 73 Matthews, Dwight E., 50 Lane, Daniel K., 53 Lowry, Oliver H., 83 Mattis, Henry E., 53 Lang, Stanley. 85 Lubowitz, Herbert, 49 Maughs, Sydney B., 91 Lange, David R., 104 Lucas, George E., 36 Mauro, Patricia M., 52 Lange, Louis G.. Ill, 49 Ludbrook, Philip R., 48, 98 Maxwell, Richard W., 52 Lansche, W. Edward, 104 Ludmerer, Kenneth M., 49 Mayer, Juanita, 125 Larson, Kenneth B., Ill, 108, 120 Lugo, Samuel, 104 Mayes, Ben R., Jr., 98 Latorre, Rodolfo A., 74 Lund, Robert H., 103 Mayhew, Thomas P., 125 Laubenthal, Nick, 125 Lyman, Edward H., 69 Maze, Laurence E., 64 Lauter, Steven A., 53 Lyss, Carl A., 53 Mazur, Michael T., 73 Laycob, Leland M., 81 Lyss, Stanley B., 80 McAfee, C. Alan, 103 Lazaroff, Richard L., 81. 109 McAlister, William H., 78, 97 Leary. Daniel J., Jr., 99 Macchiaverna, June, 125 McCarty, Michael A., 74 Leckie, Mary P., 74 MacDermott, Richard P., 50 McClennan, Bruce L., 97 Lee, Fransiska, 98, 110 Madsen. Kathleen S., 89 McClure, Julie M., 125 Lee. Joan. 74 Magee, William E., 51 McConkey, Charles L., Jr., 54 Lee, Joseph K. T., 97 Mahle, Carl 106 McCown, Allan H., 98 Lefrak. Stephen S., 48 Majerus, Philip W., 38, 47 McDaniel, Michael L., 73 Lesker, Peggy A., 105 Malone. John D. G., 50 McDivitt, Robert W., 72 Levin, Marvin E., 49 Malt. Sherwin H., 103 McDonald, Jay M., 48, 73 Levine, Laurence A., 69 Mandro. Henry, 123 McDonald, John A., 50 Levine, R. Paul. 41 Mange, Judith. 125 McDonald, Richard J., 57 Levitt, Joseph, 49 Manley, Charles B. Jr., 79, 105 McDougal, David B., Jr., 83 156 n McElvany, Karen D., 98 Monafo, William W., 103 Niemeyer, Mary, 125 McGee, Judith A., 93 Monat, Seymour M., 64 Nieuwenhuijsen, Els R., 127 McGue, Matthew K., 89 Monical, Beverly B., 123 Niman, Carol W., 127 McKee, Oliver A., 53 Monroe, Martha C, 89 Nimnicht, Terry L., 123 McKeel, Daniel W., 73 Monsees, Barbara, 99 Nobel. John P., 123 McKeon, Ann C, 60 Montgomery. Austin F., 53 Noetzel, Michael, 60, 80 McKevitt, Patricia M.. 54 Montgomery, Erwin B., Jr., 60 Nordlicht, Scott M., 51 McKinney, Joe K., 93 Montgomery, Mary A., 93 Norland, Charles C, 51 McKnight, Robert C, 50, 98 Moore, Blake W., 38, 91 Norton. Barbara J., 125 McLaughlin, Kathleen S., 74 Morales, Julio, 95 Nulty, Walter L.. Jr., 39 McLaughlin, Lynn J.. 92 Moran, Christopher J., 98 Numerof, Rita E., 122 McNeill, Sharon L., 125 Morgan, Harry C, 104 Nussbaum, Gilbert H., 98 Meacci, Charles, 125 Morgan, Tom E., 64 Nysewander, Richard W.. 94 Mecham, Robert P., 50 Morrin. Kevin C, 64 Medoff, Gerald, 47, 57 Morris, Alan H., 104 Oblander, Mary, 127 Meglan, Cathie, 125 Morrison, Aden E., 53 O'Brien, Daniel P., 69 Mehta, Jagdish M., 54 Morrison, Aubrey R., 50, 83 O'Brien, L. Woodrow, 69 Meinberg, William H., 67 Morrissey, Jeremiah J., 50 O'Brien, Richard L., 69 Melechen, Patricia J., 127 Mortensen, Frede, 53 O'Brien, Robert J., 123 Melson, G. Leland, 98 Moses, Robert A., 66 Ochs, Lamar H., 53 Meltzer, David W., 67 Mosley, Julian C, Jr., 103 Ogilvie, Robert W., 74 Meltzer, Victor N., 50 Mruk, Jozef, 54 Ogura, Joseph H., 68, 110 Mendelsohn, Robert S., 51 Mueller, John F, 93 O'Keefe, Joseph D., 65 Mennes, Paul A., 51 Mueller, Robert J., 60 Okun, Edward, 66 Menon, Mani, 105 Muller, Linda, 126 Olander, David S., 81 Menton, David N., 34, 73 Mullins, John E., 54 Oliver, G. Charles, 48, 108 Merbaum, Michael, 94 Muney, Alan M., 81 Oliver, George A., 103 Merrims, Theodore, 65 Munns, Theodore W., 50 Oliver, Ronald A., 94 Merson, Richard, 105 Munoz, Sarah Skinner, 127 Oik, Robert Joseph, 67 Meyer, Jay, 93 Munson, Robert S., 80 Ollinger, Henry, 105 Meyer, John S., 72 Murdock. Nathaniel H., 65 Olney, John W., 72, 91 Meyer, Kyle, 125 Murphy, George E., 91 Olson, Maynard V., 41 Meyers, Elsie F., 35. 66 Murphy, Mary K., 127 Omell, Gary H., 99 Meyers, Jerry R., 103 Murphy, William A., Jr., 98 O'Neal, Lawrence W., 103 Meyers, Susan, 127 Murray, Patrick R., 50, 74 O'Neal, Patricia L„ 91 Michaelides, Maria, 103 Muschany, Norman K., 64 Opstad, Elwood P., 123 Michels, Eugene, 124 Myrick, Cheryl Ann. 61 Orgel, M. Norman, 50 Middelkamp, J. Neal, 78 Orgel, S. Michael, 53 Middleton, Jerry N., 65 Nahm, Moon H.. 50, 74 Ortbals, David W., 51 Milder, Barry D., 67 Nakeff, Alexander N., 98 Osa, Steven R., 52 Milder, Benjamin, 67 Nakra, Bharat R. S., 93 Osborne, Dale F, 54 Miller, Charles W„ 53 Nakra, Rashmi R., 94 Ostlund, Richard E., Jr.. 48 Miller, Edward J., 49 Nash, Geoffrey S., 52 Ott, F. Thomas, 67 Miller, Elaine, 67, 81 Nash, Helen E., 79 Overbey, Gail A., 95 Miller, James E., 66, 78 Nash, Homer E., Jr., 80 Overton, Steven B., 69 Miller, James G., 48, 108 Nathan, Lester J., 104 Owen, James W., Jr.. 51 Miller, J. Philip, 89, 108 Needleman, Philip. 83 Owen, Robert F, 53 Miller, Peter, 125 Nelson, J. Roger, 51 Owens, William D., 35, 110 Miller, Robert F., 67, 85 Nelson, James S., 72, 78 Miller, Tom R., 98 Nemeth, Patti M., 60 Packman, Paul M., 91 Miller, William V., 48, 73 Neuman, Neal, 106 Packman, Robert C, 49 Minnich, Virginia, 47 Newell, Sara L., 54 Paine, Robert, 48 Mishkin, Marvin R., 104 Newman, Matthew, 67 Painter, Audrey A., 54 Mishra, Lalji, 54 Newmark, Leonard N., 51 Painter, Paul H., 80, 95 Mitchell, Eugene N., 103 Newport, Gerald, 65 Pal, Earni, 93 Moeller, F. Dclbcrt, 65 Newton, Gordon, 51 Palkcs, Helen, 79 Mogelson, Stanley, 50 Niccum, Joann R., 125 Panhorst, Harry E., 123 Molnar, Charles E., 85, 120 Nichols, Michael J., 81 Parker, Charles W., 47, 57 Momtazee, Sam, 65 Nickel, James F, 49 Parker, Donald J., 74

157 3i Parker, Mary L., 49, 89 Powell, John A., 53 Roa, Necita L., 36 Parks, Charles L., 103 Powell, Joseph H.. 123 Roberts, Harold K.. 51 Parrino, Peter A., 99 Powers, Jo Anne, 127 Roberts, Robert, 48 Parrish, Richard K, 105 Powers, William J., 60. 99 Robins, Eli, 91 Parsons. Patricia A., 80 Prensky, Arthur L., 59, 78 Robins, Lee N., 91 Parsons, Richard P.. 105 Presson, Wynn E., 123 Robinson, Edith C, 80 Parvin, Curtis, 74 Price, Joseph L., 34 Robison, Leon R., 51 Patel, Jashbhai l„ 99 Price, Kenneth C, 51 Roblee, Melvin A., 64 Patke, Christina L., 74 Price, Madelon L, 92 Robson, Alan M., 50, 78 Patsch, Wolfgang P. Th., 50, 89 Probstein, J.G., 103 Rocklage, Sister Mary R., 122 Payne, Richard, 74 Proskey, Vincent J., 51 Rodey, Glenn E., 47, 72 Pearlman, Alan L„ 59, 85 Purdy, James A., 98 Roeder, Robert G., 38, 41 Pearson, William E., 65 Purkerson, Mabel, L., 48, 80 Roettger, Richard F., 125 Peck, William A., 47 Purves, Dale, 85 Rogers, John C, 48 Peden, James C, Jr., 51 Rojanasathit, Chinda Vanasin, Peden, Joseph C, Jr.. 103 Quaas, Robert L., 81 65, 109 Pedersen, Claire K., 54 Quill, Helen, 54 Roos, Albert, 35, 85 Pennoyer, James, 64 Roper, Charles L., 102 Perez, Blanca M„ 73 Rachlin, Maxwell, 67 Roper-Hall, Gillian, 67 Perez, Carlos A., 97, 110 Rader, George B.. 103 Rorrie. Colin C, Jr.. 123 Perez, Julio E., 50 Rafferty, Sandra. 127 Rose, Steven J.. 124 Perez-Mesa. Carlos, 74 Rahman, Mohammad H., 81 Rosen, Dean L., 94 Perkins, Linn B., 122 Raichle, Marcus E., 59, 97, 120 Rosen, Samuel H., 93 Perlmutter, John C. 67 Raikar, Sudhir R., 81 Rosenbaum, Harry D., 67 "i Permutt, Marshall A.. 48 Rainey, Robert, 104 Rosenbaum, Herbert E., 60 Perrault, Jacques, 57 Rajappa. Muniyapla T., 93 Rosenblum, Jerry L., 80 Perrillo, Robert P., 50 Rakowski, Robert F., 85 Rosenzweig, Saul, 91 Perry, Betty F., 54 Rankin. Diane, 95 Ross, William J., 80 Perry, H. Mitchell, 47 Rao, Bantwal R., 101 Roswit, William T., 54 Perry, H. Mitchell. Ill, 52 Rao, D. Venkato, 98 Rother, Richard, 125 Perry, William D., 49 Rao, DabeeruC, 41,89, 91 Rothman, David B., 64 Perryman, M. Benjamin, 54 Raskas, Heschel J.. 57, 72 Rothman, Steven M., 34. 60, 80 Peskin, Edward G., 64, 109 Ratcheson, Robert A.. 61 Rothstein, Jules M., 125 Peters, Kenneth W., 123 Rath, Mary L., 127 Rousch, Elsie S., 34 Peterson, Frederick D., 79 Ratkin, Gary A., 51.99 Rouse, Ernest T.. 49 Peterson, Leroy W., 105 Ratliff, Timothy L., 105 Rouse. Ernest T, III, 53 Peterson, Roy R.. 34 Raymond. Marilyn, 125 Roush, Elsie S., 127 Pfeiffenberger, Mather, Jr., 103 Read. J. Larry, 123 Rouvalis, Erica, 125 Pfleger. Barbara A., 89 Reddy, Palle K., 36 Rovainen, Carl M., 85 Phillips, Gordon L., 11, 50, 98 Reed, Charles A., 81 Rowland, Phyllis, 125 Phillips, William D., 38 Reed, Diana L., 89 Royce, Robert K., 105 Phillips, William J.. 51 Reed, Jonathan R., 64 Rudd, Mary, 125 Philpott. Gordon W., 102, 110 Reese, Lester T, 51 Ruehl, Albert F., 69 Phipatanakul, Supote, 69 Reich, Theodore, 41, 91 Ruffy, Rodolphe, 50 Pickard, William F., 120 Reinach, Peter, 67 Rujanavech, Naris, 99 Pierce, Carl W., 57, 72 Reinhard, Edward H., 47 Rumelt, Michael B., 67 Pierce, Eugenia M.. 81 Reisler, David M., 60 Russ, Kenneth L., 94 Pierce. John A., 47 Rennard, Marvin, 64 Russell, Herman E., 105 Pilepich, Miljenko V., 98 Reuss, Luis, 85 Russell, John H., 83 Pittman, Susan, 80 Reynolds, Fred C, 104 Ruthrauff, James C. 123 Plax, Steven I., 80 Rice, John P., 89, 92 Rutledge, Suzanne B. 125 Plurad. Santiago. 74 Richards, Frank O., 103 Ruwitch. Joseph F., Jr., 51 Pohlman, Thomas R., 52 Richardson. Thomas F., 93 Ryall, Jo-Ellyn M., 94 Polakoski, Kenneth V., 64 Rieders, Elaine V., 74 Rysgaard, Cindy, 125 Porporis, Arthur A., 98 Riedesel, William M., II, 93 Post, Lawrence T., Jr., 67 Rifas, Leonard. 52 Sabol, Peggy S., 127 Potter, Reese H., 92 Rifkin, Shale, 103 i Sachar, Leo A., 103 Potts, Daniel E.. 53 Rigg, Lee A., 64 Safdar, Shabbir H., 49 Powell, Boone, 122 Rizzo, Adolfo E., 95 Saffitz. Jeffrey, 74

158 5 1 Sagel, Stuart S., 97 Schulz, Beatrice F, 124 Silver, Simon D., 57 Saghir, Marcel T., 91 Schuster, Daniel P., 52 Silverman, S. Richard, 68 Sahrmann, Shirley A., 60, 85, 124 Schwartz, Alfred S., 80 Simchowitz, Louis, 50 Sale, Llewellyn, Jr., 49 Schwartz, Benjamin D., 48, 57 Simmons, David J., 104 Salimi, Ali, 51 Schwartz, Henry G., 61 Simms, Ernest S., 57 Salmon, Mickey L., 67 Schwartz. Melvin M., 64 Simons, Paul S., 80, 109 Salvador, Antonio, 74 Schwartz, Ruth K., 127 Simpson, Joseph R., 98 Samadaei, Allahyar, 94 Schwartz, Susan C, 126 Simpson. Lloyd N., 60, 61 Sampathkumaran, Kondapuram S. Schwartzman, Bernard, 79 Simpson, Reed E., 93 99 Schwarz, Hans P., 52 Simril, Wayne A., 98 Samson, Barry L., 104 Sclafford, Ursula, 74 Sims, William A., Jr., 36 Samuels, Lawrence E., 53 Scott, Glenn N. 122 Sinacore, David R., 125 Sanchez-Montserrat, Rafael, 53 Scrivner, Willard C, 64 Singerman, Burton, 92 Sanders, Theodore E., 67 Scruggs, Karen L., 81 Sisk, James C, 49 Sandza, Joseph G., 102 Seddon, John W., 52 Sisson, Richard G., 103 Sanes, Joshua R., 85 Seetharam, Bellur, 50 Skinner, Geraldine, 127 Santa Cruz, Daniel, 74 Seetharam, Shakuntla S., 52 Skinner, John S., 54 Santiago, Julio V., 50, 79 Seleski, Loretta K. Cass, 95 Skowyra, Mary, 127 Santoro, Samuel A., 50, 74 Seltzer, Jo L., 50 Slatopolsky, Eduardo, 47 Sapareto, Stephen A., 98 Selven, Ramasamy, 106 Slaughter. Malcolm M., 67 Saper, Clifford B., 34, 60 Semmler, Caryl, 127 Sleight, Dixie M., 127 Sato, George, 79 Senior, Robert M., 47 Shorn, Cyril M., 36 Sato, Richard W., 81 Senturia, Ben H., 68 Sly, WilliamS., 41,47, 78 Sauer, Donald C, 103 Senturia, Hyman R., 97 Smathers, Ralph L., Jr., 99 Sauvage, Jacques, 64 Sessions, Donald G., 68, 110 Smiley, William L., 65 Sawyer, James, 65 Shackelford, Gary D., 79, 97 Smit, Herbert M., 69 Saylor, Jack L., 53 Shackelford, Penelope G., 79 Smith, Carl H., 73, 78 Scarpellini, JoAnne D., 60 Shah, Suresh D., 54 Smith, Carol S., 126 Scates, Robert F., 122 Shahan, Philip T., 67 Smith, E. Kaye, 74 Schaan. Robert C, 80 Shaikun, Gerald L., 99 Smith, Elizabeth M., 92 Scharp, David W., 103 Shanes, Jeffrey G., 52 Smith, Emily L., 98 Schechter, Samuel E., 52 Shank, Robert E., 47, 88 Smith, James B., 93 Scheer, George E. , 104 Shapleigh, John B., 11, 53 Smith, Janet L., 52 Scheff, Harold, 48 Sharer, William C, 105 Smith, Jeanne M., 60, 61 Scheff, Robert J., 53 Shatz, Burton A., 49 Smith, Kathleen, 91 Scheible, Robert F., 99 Shatz, Gerald S., 54 Smith, Marc D., 122 Scherrer, Floyce A., 67 Shatz, Richard, 105 Smith, Mary B., 127 Schieber, William D., 103 Shaw, Richard C, 102 Smith, Morton E., 66, 72, 110 Schlansky, Howard J., 81 Sheffner, Paul W., 94 Smith, Peter G., 69 Schlansky, Seymour M., 81 Shen, Victor W., 52 Smuckler, David, 54 Schlesinger, Milton J., 57 Sherman, Laurence A., 47, 72 Snyder, Donald L., 108 Schlesinger, Paul H., 85 Sherman, Warren G., 79 Sobel, Burton E., 47 Schlesinger, Sondra, 57 Sherman, William R., 38, 91 Soder, Dean, 125 Schlessinger, David, 47, 57 Shields, Helen M., 50 Sohn, Richard S., 60 Schmid, Harriet, 127 Shipton, Harold W., 108, 120 Solanki, Nareshkumar, 81 Schmidt, Robert E., 74 Shively, Robert A., 104 Sommer, Ross B., 49 Schneider, Robert J., 53 Shobe, Frank O., 91 Sonnenwirth, Alexander C, 57, 73 Schneider. Susan B., 52 Short, Ann Brown, 125 Sorensen, Craig M., 74 Schneiderman, Howard A., 38 Shreffler, Donald C, 41 Soto, Alberto, 93 Schnewerk, Carla, 127 Shuter, Eli R., 60 Soule, Samuel D., 64 Schoedinger, George R., Ill, 105 Sicard, Gregorio, 104 Southworth, William F, 52 Schoenberg, Sandra P., 92 Siegel, Barry A., 48, 97 Spector, Gene W., 99 Schoenecker, Perry L., 104 Siegel, Marilyn J., 80, 98 Spector, Gershon J., 68 Schoentag, John S., 53 Siegfried, Barry A., 50, 74 Spencer, Andrew D., 103 Schonfeld, Gustav, 47, 88 Siemers, Carolyn M., 65 Spilberg, Isaias, 48 Schrick, Richard E„ 69 Sierra, Gregorio, 74 Spitznagel. Edward L., Jr., 89 Schroeder, Kevyn F, 81 Silberberg, Ruth, 72 Spivack, Alan R., 52 Schulman, Jeffrey I., 81 Silbert, David F, 38 Srisuro, Chotchai, 65 Schultz, Earl R., 60, 92 Silver, Bernd, 67 Stahl, Philip D., 85

159 Stake, Michael N., 93 Ternberg. Jessie L., 78, 105 Varki, Ajit P., 52 Stearns, Charles B., 123 Ter-Pogossian, Michel M., 97, 120 Vastola, Edward E., 59 Stein, Jonathan S.. 99 Thach, Bradley T.. 79 Vavra, John D., 47, 88 Stein, Paul M.. 52 Thach, Robert E., 38 Venable. Philip, 67 Steinberg, Franz U., 48, 89, 105 Thach, W. Thomas, Jr., 34, 59 Viers, Wayne A., 69 Stenson. William F, 50 1 hallinger, Gertraude. 69 Vietti, Teresa J., 78, 97, 110 Stephen, C. R., 35 I halmann, Isolde. 69 Vinjamuri, Madhav, 36 Stephen, George A., 126 I halmann, Ruediger, 68 Voege, Barbara N., 81 Stewart. Frances H., 65 Thawley, Stanley E., 69 Volpe, Joseph J., 38. 59, 78 Stewart, James D„ 123 Thiel, J. Allen, 49 Votaw, Robert E., 69 Stickle, Arthur W., Jr., 67 Thiele, Belmont R., 103 Sailings, Wayne A., 94 Thies, Curt, 120 Wade. Robert P.. 95 Stine, Robert J., 50, 104 Thoele, Charles E., 123 Wadsworth, Donald E., 99 Stoddard, Elizabeth A., 52, 89 Thomas, Lewis. J.. Jr.. 35. 85, 108, Wald, Deborah E.. 93 Stokes, James M., 103 120 Wald, Stanley M., 49 Stoltzman. Roger K., 92 Thomas. Lorraine L., 81 Waldbaum. Lawrence S., 36 Storch, Gregory A., 52, 80 Thomas, Patrick R. M., 98 Walker, J. Leslie, 65 Stottlemyer, Keith D.. 54 Thompson, Lloyd. 69 Walker, Willard B., 103 Stralka, Mary J., 81 J hompson, M. Bryant, 65 Wallach, Elliot A., 52 Strauss. Arnold W., 39, 79 Thomson, William M., 54 Wallack, Marc K.., 103 Strecker, William B., 104 Thurston, Donald L.. 78 Walsh, James W„ 52 Strickler, Ronald C, 64 Thurston, Jean H., 78 Walters, Richard C, 54 Strobach, Debra L., 125 Tiefenbrunn, Alan J., 50, 98 Waltman, Stephen R., 66 Strominger, Donald B., 79 Tiefenbrunn, Sharon F., 54 Walz, Bruce J., 98 Stroud. Malcolm H.. 68 Tillman, Mary A. T, 80 Wann. Donald F, 120 Stubcrg, Wayne A., 126 Tilton, Ronald G., 74 Ward, Diane E., 127 Sturley. Bettie, 127 Tobey, Albro C, Jr., 65 Warden, Gail L., 123 Suarez, Brian K.. 41,91 Toga, Arthur W., 60 Warmbrodt, John, 123 Suchenski, Richard C., 123 Tollel'sen, Douglas M., 50 Warren, James C, 38, 64 Sulrin, Gerald, 105 Tolmach, Leonard J., 34, 97 Warren-Boulton, Elizabeth, 52 Sullivan. James H., 123 Tomeldan. Silvestre A., 36 Wasserman, Helman C, 64 Sumer, Cengiz M., 93 Torack, Richard. 73 Wasserman. Sally, 125 Sumer. Emel A., 95 Totty, William G., 98 Wasserman. Todd H.. 98 Sundermann. Joan E., 126 Trivedi, Bakula L., 54 Waters. Hugh R., 54 Sunshine. Herbert, 106 Trotter, Alice W., 54 Waterston, Robert H., 34, 41 Sunwoo. In Sook, 89 Trotter, John L., 60 Watson, M. Frances, 89 Suri, Jagdish C., 95 Trotter, Mildred, 34, 99 Wattenberg, Carl A., 105 Susman. Noah, 98 Tschoepe. Barbara A., 125 Waxelman, Roger J., 81 Sutera, Salvatore P., 120 Tsifutis. Argyrios A., 79 Wedner. H. James, 48 Sutter, Richard A„ 89 Tubbs. Garth D., 127 Wee, George C, 103 Swan, Marlene R., 127 Tucker, Dolores R., 54 Weeks, David G., 95 Swaneck, George E.. 105 Tucker. George L., 103 Weeks, Paul M., 105, 111 Sweet, Frederick, 64 Tumialan, Luis, 74 Weerts, Carol A., 54 Sweet. John. 93 Turner, James K.., 79, 109 Weger, Lillian B., 95 Tuteur, Peter G., 48 Weil, Gary J., 52 Iaibleson. Mitchell, 91 Tyson, Ellen T., 127 Weiss, Alan N., 52 Tailor, Chandrakant C, 98 Weiss, Stuart, 60 Talent, Barbara K., 80 Uhlemann, John H., 54 Welch, Michael J., 97 Tang, Moon-Shong, 74 Weldon, Clarence S., 79, 102 Tanphaichitr, Kongsak. 50, 109 Valdes. Andres J., 74 Weldon, Virginia V., 79 Taussig, Barrett L., 50 Valdes. Orestes S., 81 Welgus, Howard G., 50 Taylor, Eugene D., 65 Valdes, Roland, Jr., 74 Wells, Samuel A., Jr., 102 Taylor, John R.. 92 Vallurupalli. Vijayalakshmi, 36 Welner, Zila, 80, 95 Taylor, Sallie E., 127 Van Amburg, Albert L., 111. 54 Wenneker, Alvin S., 49 Taysi, Kutay, 79 Vanderpearl, Robert H., 92 West, Joseph W., 69 Taxman, Robert M., 52 Van Eerdewegh. Michele. 92 Wette, Reimut, 88, 120 Teitelbaum, Steven L., 73 Vannier. Michael W.. 98 Wetzel, Richard D., 91 Templeton, Alan R., 41 VanSweden. Martha. 127 Weygandt, Glenn R., 35 Tepper. Arnold S., 54 VanZant, Gary E., 98 Weyman, Philip J., 98

160 j

Wheatt. Theodis M., 94 Winstead, Elsie, 54. 109 Wrenn. Richard. 39 White. Bruce I.. 105 Winters, Kathleen, 80 Wulf. Maureen, 125 White, Neil H., 80 Wippold, Franz J.. 11,99 Wulff, George J. L.. Jr.. 64 White. Park J., 79 Wissmath. Frank S., 79 Wunderlich, Paul H.. 123 Whiteside. Leo A., 104 Witt, Mary F. 52 Whyte, Michael P.. 50 Wochner, R. Dean. 47, 89 Yang, Joseph W.. 52 Wiant, James R., 54 Wochnik, Eliza E., 95 Yanow. Mitchell, 65 [ i Wiedershine. Leonard J., 93 Wolf, Mitchel L., 67 Yates, Jesse T., 54 Wiegand. Herbert C, 54 Wolfe, Edward M.. 54 Yochum, Katherine A., 126 Wiest. Walter G., 39, 64 Wolff, Gerald A.. 52 Yokoyama. Shozo. 41. 92 Wilbois, Ronald P., 65 Wolff, Harold D., 92 Young, Vernon L.. 105 [ i Wilkins, George T., Jr., 80 Wolff, Patricia B., 81, 109 Wilkinson, Robert S.. 85 Wolfgram, Edwin D., 93 Zachek, Michael J.. 54 Willard, Mark B., 34, 39 Wood, James A., 54 Zahalak. George I. 120 Williams, Carol F., 65 Wood, John A.. 52 Zangara, Richard J.. 52 [ i Williams, R. Jerome, Jr., 54 Wood, Patrick M., 34 Zarkowsky, Harold, 79 Williamson, Janet E., 127 Woodall, Barbara A., 125 Zeffren, Jacob M., 54 Williamson. Joseph R., 73 Woodward, Robert S., 89, 122 Zibit, Helen L.. 95 Wilner. George D„ 50, 73 Wool, Gerald, 80 Zielinski, Pat. 127 Wilson, Keith S„ 50 Woolsey, Thomas A., 34, 85 Zimmerman, Herbert B., 52 Wilson, Nancy, 126 Wooten, George F, Jr.. 60, 83 Zivnuska, Frederick R., 99 Wilson, Susan, 127 Word, Parker H., 65 Zografakis, George H., 105 Windsor, Charles E., 67 Worland. Julien, 95 Zuckerman. Gary R., 50 n Winer, Michael H., 104 Wray, Robert C, Jr.. 105 Zwirn, H. Benjamin, 81 f "| Schools of Washington University

All schools are located on the main campus at THE GRADUATE SCHOOL OF BUSINESS Lindell and Skinker Boulevards, St. Louis. Missouri 63130. except Medicine (660 South Euclid Avenue, 63110) ADMINISTRATION and Dental Medicine (4559 Scott Avenue, 63110). A University-sponsored shuttle bus travels between the THE SCHOOL OF FINE ARTS main campus and the medical/dental campus every 20 minutes. THE SCHOOL OF SOCIAL WORK

THE COLLEGE OF ARTS AND SCIENCES THE SCHOOL OF LAW

THE GRADUATE SCHOOL OF ARTS THE SCHOOL OF MEDICINE AND SCIENCES THE SCHOOL OF DENTAL MEDICINE

THE SCHOOL OF ENGINEERING AND UNIVERSITY COLLEGE APPLIED SCIENCE THE SUMMER SCHOOL THE SEVER INSTITUTE OF TECHNOLOGY The information which appears in this Bulletin was THE SCHOOL OF ARCHITECTURE compiled in the spring of 1982. It is current as of April 1. 1982. THE SCHOOL OF BUSINESS AND PUBLIC ADMINISTRATION

161 Washington University

FOREST PARK

LINDELL BOULEVARD

1. Spencer T. Olin Residence Hall 2. McDonnell Medical Sciences Building 3. North Building 4. Cancer Research Building 5. South Building 6. West Building 7. Irene Walter Johnson Institute of Rehabilitation 8 McMillan Hospital and Oscar Johnson Institute for Medical Research 9. St. Louis Maternity Hospital 10. David P. Wohl. Jr.. Memorial-Washington University Clinics 11. Renard Hospital 12. David P. Wohl, Jr.. Hospital 13. Barnard Free Skin and Cancer Hospital 14. Edward Mallinckrodt Institute of Radiology 15. Barnes Hospital a. Medical Wing b. Rand-Johnson Memorial Surgical Wing c. Queeny Tower d. Diagnostic Laboratories. Service Center e. East Pavilion f West Pavilion 16. Clinical Research Building 17. St. Louis Children's Hospital 18 700 and 724 South Euclid Buildings a. Biomedical Computer Laboratory b. Physical Therapy c. Hospital Administration, Biostatistics d. Computer Systems Laboratory 19. Central Institute for the Deaf 20. Central Institute for the Deaf Residence 21. School of Dental Medicine 22. Occupational Therapy 23. Power Plant 24. Medical Care Group 25. Jewish Hospital a. West Building b. Shoenberg Pavilion c. Medical Building d. Nursing Residence 26. Parking a. Public b Washington University Medical School Permit Parking Only c. Jewish Hospital d. Barnes Hospital Permit Parking Only e. Underground Garage 27 Medical Library Archives WASHINGTON UNIVERSITY MEDICAL CENTER

LINDELL BOULEVARD

U S HIGHWAY 40 Departments and Divisions Hospital Administration, see Index Allied Health Professions, 121 Health Administration, 121 1 Anatomy and Neurobiology, 32 Hospitals and Institutes, 29 Anesthesiology. 35 Hours, Required, 7 Biological Chemistry, 37 Housing, 21 Genetics, 40 Administration, 131 Graduate Training, 112 I Admission, 13 Medicine, 42 Immunology, see Microbiology American Medical College Microbiology and and Immunology, 55 Application Service, 13 Immunology, 55 Index of Staff Members, 150 Application Procedure, 13 Neurology and Neurological Individualized Programs, 8 Entrance Requirements, 13 Surgery. 58 Instruments, see Expenses, 15 Transfer, 14 Obstetrics and Gynecology. 62 Internships. 12 Affiliated Hospitals, 29 Ophthalmology. 66 Interview, 14 Allied Health Professions Otolaryngology, 68 Irene Walter Johnson Institute of Health Administration, 121 Pathology, 70 Rehabilitation, 111 Occupational Therapy, 126 Pediatrics, 75 Pcdiatric Nurse Practitioners, 129 Pharmacology, 82 Physical Therapy, 124 Physiology and Biophysics, 84 Radiologic Technology, 130 Lectureships. 24 Preventive Medicine and Physician's Assistant Library. 28 Public Health, 86 Training Program, 128 Loan Funds. 17 Psychiatry, 90 Alumni Association. 23 Radiology, 96 Anatomy and Neurobiology, 32 M Surgery, 100 Anesthesiology, 35 Map, 160 r Teaching and Research Application Procedure, 13 Medical Care Group, 109 Divisions. 107 Awards and Prizes, 19 Medical Center, 29, 132 Medical College Admissions B Test, New, 13 Early Decision Admission, 14 Beaumont-May Institute of Medical Scientist Training Electives, 7 Neurology, 110 Program, 8 Entrance Requirements, 13 Biological Chemistry, 37 Medicine, 42 Executive Faculty, 133 Biology and Biomedical Sciences, Medicine, The Study of, 6 Expenses, 17, 21 Division of, 112 Microbiology and Immunology, 55 Biomedical Computer Microscope, 15 Laboratory, 27, 107 Biomedical Engineering. 120 Faculty Council, 133 N r Faculty Index, 150 Biophysics, see Physiology and Neurology and Neurological Biophysics, 84 Fees, 12, 18, 112, 124, 126, 129, 130 Surgery, 58 Fellowships, 15, 21 Board of Trustees, 131 Neurology, Institute of, 110 Financial Assistance, 15, 112 Buildings, 27 Nondiscrimination, 6 Financial Information, 15 First-Year Curriculum, 6, 11 C O Calendar. 4 c; Objectives, 6 Child Psychiatry, 95 Obstetrics and Gynecology, 62 Clinical Clerkship, 7 Genetics. 40 Occupational Therapy, 126 Clock Hours, 7 Grades. 10 Officers and Committees, 133 Combined M.D./Ph.D. Program, 8 Graduate Training Olin Residence Hall, 21 Committees of the Faculty, 133 Biology and Biomedical Ophthalmology, 66 Cultural Opportunities, 22 Sciences, 112 Otolaryngology, 68 Curriculum. 6. II Biomedical Engineering. 120 Gynecology, see Obstetrics and D Gynecology. 62 P Degree Programs Parking, 22 H B.S.O.T., 126 Pathology, 70 B.S.P.T, 124 Health Administration, 121 Pediatric Nurse Practitioners, 129 Combined M.D./ Ph.D. degree, 8 Health Service, 21 Pediatrics, 75 M.D. degree. 8 Historical Perspective, 25 Personal Interview, 14 M.H.A., 121 Honors. 10 Pharmacology, 82

164 1 i I:

Ph.D./M.D. Program, 8 Register of Students, 135 Philosophy and Objectives, 6 Rehabilitation, Institute of. 111 Teaching and Research Divisions Physical Therapy, 124 Required Hours, 7 Biomedical Computer Physician Assistant Training Research Fellowships, 12 Laboratory, 27, 107 Program, 128 Residencies, 12 Neurology, Institute of. 110 Physiology and Biophysics, 84 Rehabilitation, 111 Postdoctoral Training, 12 Tumor Services, 110 Premedical Requirements, 13 St. Louis, City of, 25 Teaching Facilities, 27 Preventive Medicine and Public Scholarship Funds, 16 Transcripts, II Health, 86 Schools of the University, Transfer Students, 14 Prizes, 19 Second-Year Curriculum, 7. II Trustees, 131 Programs, Individualized, 11 Staff Members, Index of, 150 Tuition, 12, 18, 112, 124, 126, 129, 130 Promotions, 10 Student Activities, 21 Tumor Services, 110 Psychiatry, 90 Student Life, 21 Tutorials, 10 Public Health, see Preventive Student Research Fellowships, 12 Medicine and Public Health. 86 Students. Register of, 135 Study of Medicine, 6 Visiting Professorships. 24 R Surgery, 100 Radiologic Technology, 130 Radiology, 96 Recreational Opportunities, 22

i ] 165 WASHINGTON UNIVERSITY IN ST LOUIS

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