BIOCHEMICAL SOCIETY

1988

Volume 16

Managing Editor D. C. WATTS

London: The Biochemical Society © 1988 AUTHOR INDEX

Aaronson, P. I. See Bolton, T. B. Altinel, A. See Wali, F. A. Augood, S. J. Abrahmsen, L. See Uhlen, M. Alving, C. R. See Richards, R. L. ; Emson, P. C; Crossman, A. R.; Ackrill, A. M Alwan, A. F. Marsden, D.; Legon, S. ; Blair, G. E. ; Jordan, P. M. Localization of enkephalin mRNA in Modulation of expression of major Isolation of uroporphyrinogen III the monkey. 313 histocompatibility class I genes in synthase from E. coli. 965 Austen, B. See Malik, Z.; Meredith, highly oncogenic adenovirus-trans= Amirali, S. See Saeed, S. A. C. formed rat cells. 605 Ancel, R. See Urban, P. F. Austen, B. M. See Hurley, P. R. Adam, L. P. See Hathaway, D. R. Anderson, A. J. See Haywood, G. W. Austin, J. C. See Chittock, R. S. Adams, D. J. See Othman, Y. H. S. Anderson, E. See Watson, D. Ayad, S. See Grant, M. E. Adams, R. L. P. See Yesufu, H. M. I. Anderson, N. G. See Kilgour, E. Ayling, C. See Moreland, B. H. Agathocleous, D. C. Andrews, S. C. Aynsley-Green, A. See Kozlowski, U. ; Cosstick, R.; Galpin, I. J.; McLen= ; Guest, J. R. M.; Turnbull, D. M. nan, A. G.; Page, P. C. B.; Prescott, Structural comparison of the guano^ M. sine 5'-phosphate reductase and Biological activity of (N*-N6)-bridged inosine 5'-phosphate dehydrogenase Bachar, O. See Michaelson, D. M. diadenosines. 756 of Escherichia coli. 858 Backwell, F. R. C. Agius, L. See Betley, S.; Tosh, D. ; Treffry, A.; Harrison, P. M. ; Elmore, D. T.; Williams, C. H. Ahkong, Q. F. Studies on the subcellular processing The use of neuropeptidases to release ; Lucy, J. A. of iron dextran by rat liver. 854 drug from peptide-based prodrugs. Localized osmotic forces and mem= Angal, S. See Marston, F. A. O. 214 brane fusion. 882 Angel, J. F. See Sohal, P. S. ; Williams, C. H. Ahmad, K. A. Anner, B. M. Photoaffinity labels for the active ; Stewart, G. S. A. B. ; Rey, H. G.; Meda, P. site of monoamine oxidase. 214 Cloning of the lux genes into Lacto= The use of liposomes in the study of Badawy, A. A. B. bacillus casei and Streptococcus sodium-potassium ATPase. 914 Effects of alcohol on tryptophan lactis: phosphate-dependent light Antoniou, M. See Faruque, S. M. metabolism. 254 production. 1068 Antoniw, J. See Piper, P. J. Bagby, S. Aitken, A. See Evans, R. W. Arata, Y. See Jefferis, R. ; Barker, P. D.; Di Gleria, K.; Hill, Alton, J. F. See Rugg, E. L. Archard, L. C. See Hayes, L. J.; Por= H. A. O.; Lowe, V. J. AI-Ani, B. S. S. ter, C. D. The direct electrochemistry of cyto= ; Coleman, G. Arden, G. B. chrome bs at peptide-modified gold Humoral antibody response to extras ; Carbrera, C; Hardcastle, A. J.; electrodes. 958 cellular, intracellular and cell enve= Kundaiker, S.; Mitchell, C. H.; Voa= Bailey, C. J. See Lockhart, B. P. lope proteins of Staphylococcus den, M. J. Bailey, E. See Barton, H. C. aureus in cases of staphylococcal Induction of photosensitivity in the Bailey, G. S. See Swann, I. D.; Sym= endocarditis. 997 Xenopus oocyte by injection of ington, P. R. Albrechtsen, M. See Kerr, M. A. retinal mRNA. 299 Baker, D. P. Ali, P. See Scott, J. E. Armstrong, F. A. ; Fewson, C. A. Ali, P. O. See Simpson, A. J. G. ; Ellul, H.; Hanlon, S. E. B.; Lan= Purification and characterization of Allan, G. non, A. M. D-(-)-mandelate dehydrogenase ; Dooley, M.; Gregory, B.; Clynes, Cryokinetic studies of cytochrome c from Rhodotorula graminis KGX M.; Headon, D. R. in aqueous alcohols. 846 39. 865 Hormonal regulation of epidermal ; George, S. J.; Thomson, A. J.; Baker, P. R. growth factor receptor gene in T47D Yates, M. G. ; Reid, A. D.; Slow, Y.; Baty, J. D.; breast cancer cells. 173 Redox properties of Azotobacter Willis, R. G. Allard, S. A. See Horsfall, A. C. 7-iron ferredoxin. 840 Identification of bile acids in breast Allen, A. See Hutton, D. A.; Mall, A. ; Lannon, A. M. cyst fluid. 741 S. Towards macromolecular recognition Baldwin, S. A. See Kasanicki, M. A. Allen, A. K. See Rossell, R. J. at electrodes: fast interfacial electron Ball, R. The glycoconjugates of mammalian transfer to cytochrome c peroxidase ; Daly, M.; O'Meara, A.; Hallinan, parasites with particular reference at graphite electrodes is promoted F. to Trypanosoma cruzi. 257 by aminoglycosides. 842 Characterization by immunoblotting Allen, D. See Kuchta, R. D. Artymiuk, P. J. See Spiro, S.; Thom= of an altered form of antithrombin Allen, M. J. as, C. D. III (ATIII). 374 ; Johnson, P. Arvin, B. See Neville, L. F. Ball, S. G. See Ong, M. L. Monoclonal antibodies as probes for Ase, K. See Shearman, M. S. Balson, D. F. See Thomas, C. D. exposed determinants on desmin Ashall, F. See Kendall, G. Barber, J. See Howard, T. D. intermediate filaments. 52 Ashford, A. See Swann, I. D.; Syming- Bardocz, S. See Grant, G. Allis, J. L. See Endre, Z. H. ton, P. R. Barker, C. J. ; Endre, Z. H.; Radda, G. K. Ashton, A. C. ; Morris, A. J.; Kirk, C. J.; Michell, Differentiation between intra- and ; Edwards, K.; Dolly, J. O. R. H. extra-cellular components of renal Lack of detectable ADP-ribosylation Inositol tetrakisphosphates in WRK-1 rubidium-87 nuclear magnetic reso= in synaptosomes associated with cells. 984 nance spectra by lineshape analysis. inhibition of transmitter release by Barker, G. A. 806 botulinum neurotoxin A and B. ; Ellory, J. C. Allsopp, M. T. E. P. See Day, I. N. 883 Sodium-dependent proline uptake in M.; Hooper, C. M. Action of botulinum neurotoxin A on isolated chondrocytes. 894 Al-Mahdawi, S. See Shallal, A. protein phosphorylation in relation Barker, P. D. See Bagby, S. Almar, M. M. to blockade of transmitter release. ; Guo, L. H.; Hill, H. A. O.; Sangh- ; Diaz-Mayans, J. J.; Ferrando, M. 885 era, G. S. D.; Romero, F. J. Ashton, S. See Scragg, A. H. The direct electrochemistry of pro• Glutathione content, glutathione Atkinson, T. See Perry, N.; Spencer, tein-protein complexes. 957 S-transferase and Y-glutamyltran^ P. ; Hill, H. A. O.; Sanghera, G. S.; speptidase activities in mid-gut Atta-ur-Rahman See Saeed, S. A. Eady, R. R.; Thorneley, R. N. F. gland of Procambarus clarkii: time Atwell, M. M. The direct electrochemistry of flavor course in the presence of cadmium. ; Hanson, P. J. doxin from Azotobacter chroococcum 23 Effect of pertussis toxin on action of at a graphite electrode promoted by inhibitors of acid secretion by isolate aminoglycosides. 959 ed parietal cells of the rat. 281

1101 1102 AUTHOR INDEX

Barlow, D. J. Bell, E. See Janson, L. late steroidogenesis in cultured ; Hider, R. C; Singh, S.; Wibley, K. Modification of the ADP regulatory bovine adrenal zona fasciculata/reti^ S. site of glutamate dehydrogenase by cularis cells through two independ= Computer-aided modelling of the PLP-AMP. 861 ent second messenger systems. 983 structures and metal-ion affinities Bell, J. D. Bird, S. J. of chelating agents. 835 ; Brown, J. C. C; Kubal, G.; Sadler, ; Forster, S.; Lloyd, J. B. Barnard, E. A. See Marshall, J. P. J. Mechanism of dipeptide translocation Barnett, C. R. See Snell, K. Nuclear magnetic resonance studies across the lysosome membrane. 42 Barnwell, S. G. See Hughes, W. M. on blood plasma and plasma pro• Bitensky, L. See Roberts, J. A. Baron, A. J. See Jones, K. M. teins: the recognition system for Bittles, A. H. See Monks, N. J. Barraclough, R. anions. 714 Bjaaland, T. Control of expression of the novel Bell, J. E. See Goldstein, B. M. ; Jones, P. M.; Howell, S. L. potential calcium-binding protein, Benito, M. See Lorenzo, M. Arginine-induced glucagon secretion p9Ka, in cultured rat mammary Benkovic, S. J. See Kuchta, R. D. from electrically permeabilized cells. 1061 Bennun, A. See Casciano, C.; Vicario, islets of Langerhans. 1017 Barrie, A. P. P. Black, D. ; Nicholls, D. G. Berchtold, M. W. See Seto-Oshima, ; Robins, S. P.; Duncan, A.; Mara= Presynaptic regulation of glutamate A. bani, M. release from guinea pig cortical Beresford, J. See Mangnall, D. Analaysis by high performance liquid synaptosomes. 881 Berridge, M. J. See Galione, A. G.; chromatography of two hydroxypyri^ Barry, F. See Murphy, G. Taylor, C. W. dinium cross-links of collagen in Barth, P. T. Berry, A. See Perham, R. N. urine as indexes of disease activity ; Bust, C; Hawkins, H. C; Freed= Berry, D. R. in rheumatoid arthritis. 817 man, R. B. Microbiological, biochemical and Black, F. M. Protein disulfide-isomerase activity genetic aspects of distilling process^ ; Wakelam, M. J. O. in bacterial osmotic shock prepara^ es. 1079 Desensitization of prostaglandin tions. 57 Berry, M. See Johnson, A. R. F2a-stimulated inositol phosphate Bartlett, K. See Bhuiyan, A. K. M. J.; Berry, R. M. generation in ras-transformed cells. Kozlowski, U. M. ; Punchard, N. A.; Maclachlan, N. 990 ; Watmough, N. J.; Causey, A. G. A.; Thompson, R. P. H. Blackburn, G. M. See Taylor, G. E. Intermediates of ^-oxidation. 410 Oxygen uptake in peroxide-stressed Blair, G. E. See Ackrill, A. M.; Grif= Barton, C. H. human red blood cells: a method fiths, S. A. ; Dickson, G.; Gower, H. J.; Walsh, for assessing antioxidant defenses. Analysis of recombinant plasmids F. S. 284 containing cloned viral genes by Structure and expression of neural Best, L. See Bone, E. A.; Tuersley, M. agarose gel electrophoresis and cell adhesion molecule complement D. restriction endonuclease digestion. tary DNA clones in skeletal muscle. ; Bone, E. A.; Meats, J. E.; Tomlin= 763 457 son, S. ; Sawecka, J.; Griffiths, S. A.; Zaj= Barton, H. C. Role of intracellular pH as a signal del, M. E. B. ; Bailey, E. in the stimulation of pancreatic Biosynthesis of 2',3'-cyclic nucleotide Changes in the specific activities of islets. 807 3'-phosphodiesterase (Wolfgram hepatic NADP-dependent dehydro^ Bestor, T. proteins) in rat brain and glioma genases during development of the Structure of mammalian DNA me= cells. 212 rat. 899 thyltransferase as deduced from the Blake, N. W. See Porter, C. D. Bashford, C. L. See McSheehy, P. M. inferred amino acid sequence and Blanchard, A. D. See Ryan, A. J. J. direct studies of the protein. 944 ; Billett, M. A. Bassett, J. H. D. Betley, S. Analysis of ubiquitinated nuclear ; Vogel, U. S.; Thompson, R. J. ; Agius, L. proteins using specific antibodies. Molecular analysis of human 2l,3*-=: Regulation of fatty acid metabolism 1059 cyclic nucleotide 3'-phosphohydro= by growth hormone and triiodothy• Blundell, T. L. See Thornton, J. M. läse. 304 ronine in cultured rat hepatocytes. Bolton, A. E. See Fairclough, A. C; Basurko, M. J. See Darriet, M. 1002 Lea, R. G.; Pockley, A. G. Batayneh, N. See Hodgson, J. A. Betteridge, A. See Martin, B. T. Bolton, T. B. Bates, P. C. See Yahya, Z. A. H. Bevington, A. See Kemp, G. J. ; MacKenzie, I.; Aaronson, P. I.; Baty, J. D. See Baker, P. R.; Lindsay, Bhatti, A. R. Lim, S. P. R. M. ; Burdon, J.; Williams, A. C; Pall, Calcium channels in smooth muscle Baum, H, See Chelliah, J.; Monks, N. H. S.: Ramsden, D. B. cells. 492 J.; O'Connell, M. J. Synthesis and investigation of bovine Bomford, A. See Ward, R. J. The changing scene in the advanced plasma amine oxidase inhibitory Bond, P. See Scragg, A. H. biochemistry undergraduate curricu= properties of analogs of the neuro= Bone, E. A. See Best, L. lum. 513 toxin N-methyl-4-phenyl-l ,2,3,6-= ; Best, L.; Tomlinson, S. Bautista, J. M. tetrahydropyridine. 335 Nutrient stimuli enhance the tumo= ; Garrido, A.; Soler, G. Bhuiyan, A. K. M. J. ver of GTP in rat pancreatic islet Effect of NADP+ and NADPH on ; Bartlett, K. cells. 809 controlled tryptic cleavage of glu= Reverse-phase high-performance Bonser, N. See Middleton, A. cose-6-phosphate dehydrogenase liquid chromatographic analysis of Boobis, A. R. See Freeman, A.; Mur= from Dicentrarchus labrax (bass) short-, medium- and long-chain ray, B. P.; Nasseri-Sina, P.; Rich, liver. 903 acylcarnitines in urine and plasma. K. J. Baydoun, E. See Hussain, S. T. 796 Booth, A. G. Beattie, R. E. Bickle, T. A. See Price, C. ; Parish, J. H.; Smith, K. R. ; Douglas, A. J.; Elmore, D. T.; Biggins, J. A. See McDermott, J. R. Use of computers for tutorial and Murphy, R. F.; Walker, B.; Wil= ; McDermott, J. R.; Lauffart, B.; simulation in teaching molecular Hams, C. H. Mantle, D. biology. 764 The behavior of leucine aminopepti= High Mr multicatalytic peptidases in Booth, R. F. G. See Gladwin, A. M. dase towards N-methyl-L-leucine human and rat brain. 852 Bootman, M. D. See Tones, M. A. chloromethyl ketone. 186 Billett, M. A. See Blanchard, A. D.; Borlakoglu, J. T. ; Williams, C. H.; Elmore, D. T. Ryan, A. J. ; Dils, R. R.; Edwards-Webb, J. D.; L-Leucine thioamide as an inhibitor Birch, N. J. See Hughes, M. S.; Par= Walker, C. H. of leucine aminopeptidase. 185 tridge, S.; Thomas, G. M. H.; Wil= Changes in fatty acid desaturase Bedwell, J. See Tarn, R. C. son, A. S. activity and of arachidonate in Beesley, A. C. H. See Lawrence, G. Birchall, J. D. See Heywood, B. R. proliferating endoplasmic reticulum M. Bird, I. M. of pigeon and rat liver in response Behan, J. ; Lightly, E. R. T.; Walker, S. W.; to polychlorinated biphenyls. 1072 ; Kelly, C. T.; Fogarty, W. M. Williams, B. C. Born, G. V. R. See Briggs, A. D.; Len= Resolution of the a-glucosidases of Adrenaline and angiotensin II stimu• don, C. L. Streptomyces tosaensis. 180 AUTHOR INDEX 1103

Bosch, M. Brown, G. See French, P. J. Campbell, I. D. See King, G. F.; ; Trombetta, S.; Parodi, A. J. Brown, J. C. C See Bell, J. D. Odoom, J. E. Synthesis of dolichol derivatives and Brown, J. T. See Charlwood, B. V. Campbell, S. See Thornton, J. M. protein glycosylation in trypanoso- Brown, M. C. S. Carafoli, E. matids. 268 ; Lunt, G. G.; Stapleton, A. Calcium homeostasis in excitable Botham, K. M. See Sutton, C. M. Further characterization of the bind= cells. 519 Bottomley, R. See Malik, Z. ing site for [35S]t-butylbicycIophos= Carbonnelle, V. Bowen, D. M. See Palmer, A. M. phorothionate in locust ganglia ; Wattiaux, R.; Wattiaux-De Con= Bown, K. See Spencer, P. membranes. 475 inck, S. Box, R. J. Brown, P. See Boyhan, A. Plasma membrane of normal and ; Portenier, M.; Staehelin, M. Brown, P. D. ischemic rat liver. 537 Evidence that in S49 cells 0-adre= ; Case, R. M.; Donohue, M.; Elliott, Carbrera, C. See Arden, G. B. nergic receptor internalization is A. C; Lau, K. R. Carey, E. M. not directly involved in the desensi^ A rise in intracellular calcium is not ; Reynolds, R.; Herschkowitz, N. tization of adenylate cyclase. 308 by itself sufficient signal to trigger Expression of 2',3'-cyclic nucleotide Boyce, S. J. the acetylcholine-induced intracel^ 3'-phosphohydrolase and myelin ; Mantle, T. J. lular acidosis in rabbit mandibular basic protein, and formation of Immunocytochemical localization of salivary gland acinar cells. 993 oligodendrocytes in mixed glial glutathione S-transferase subunits Brown, S. J. cultures maintained in a defined in rat brain. 386 Adenosine and ATP: presynaptic medium. 900 Boyd, R. S. effects at the cholinergic nerve Carey, F. See Creba, J. A. ; Wallis, M. terminal. 442 ; Das, A. M.; Ha worth, D.; Heron, G-proteins and the control of prolac= Brozovich, F. V. See Morgan, K. G. J. R. M. tin and growth hormone secretion. Bruckdorfer, K. R. See Dunn, R. C. Activation of protein kinase C in the 887 Bruggeman, M. See Walker, M. R. development of experimental hyper^ Boyhan, A. Brunt, R. V. See Sharif, M. A. algesia. 818 ; Brown, P.; Lydon, J.; Dobson, A. Buchanan, C See Yahya, Z. A. H. Carr, G. D. W.; Headon, D. R. Buehne, S. See Kunau, W. H. ; Ferguson, S. J. A 65 kDa inhibin from bovine follicu^ Bunce, C M. See French, P. J. Nitric oxide reductase of Paracoccus lar fluid. 212 Bungard, S. J. See Smith, L. D. denitrificans. 187 Bradbury, J. M. Bunn, D. N. Carr, V. J. See Masters, D. J. ; Edwards, P. A. W. ; Smith, P. E. Carroll, K. Use of a retrovirus vector system to Developments in biochemistry in ; O'Kennedy, R. study the effect of v-fos on a mam• applied biology degrees. 587 Interference effects from Nonidet mary epithelial cell line. 1019 Burch, A. M. P-40 and urea in the Bradford Bradbury, N. A. See Shori, D. K. ; Rigby, S. E. J.; Funk, W.; protein assay. 382 Bradford, H. F. See Watton, J. Macgillvray, R. T. A.; Mauk, A. G.; The use of Balb/c mice for the elimi^ Bradley, B. A. See Kumpel, B. M. Mauk, M.; Moore, G. R. nation of mycoplasma from infected Bradley, J. G. M. A carbon-13 nuclear-magnetic-reso^ hybridomas. 398 ; Cotter, T. G. nance investigation of the interact Carson, M. A. See Conneely, O. M. NB-1, a monoclonal antibody which tion between cytochrome c and Carter, N. inhibits pH] thymidine uptake by cytochrome b$. 844 ; Jeffery, S.; Nieminen, P.; Lindros, stimulated lymphocytes. 383 Burchell, B. See Coughtrie, M. K. Brain, A. I. J. See Wali, F. A. Burdon, J. See Bhatti, A. R. Expression of glutamine synthetase Brammer, M. Burgess, A. J. and carbonic anhydrase in isolated ; Sardiwal, S.; Weaver, K. ; Norman, R. 1. periportal and perivenous hepato= Depolarization enhances carbachol-^ Characterization of calcium channel cytes. 572 stimulated polyphosphoinositide subunit. 452 Carville, D. See Eason, S. breakdown in rat cortical synapto= Burke, A. B. Casciano, C. somes. 320 ; Huckle, K. R.; Millburn, P. ; Bennun, A. Brand, M. D. See Quant, P. A. Comparative fate of 2-phenyldode:=: A characterization of two inhibitors Brearley, C. A. cane in rat and rainbow trout. 25 of proton-potassium ATPase in ; Lloyd, A. W.; Hodges, N. A.; 01= ; Millburn, P.; Huckle, K. R. gastric tissue. 27 liff, C. J. The metabolism of 3-phenoxybenzoic Case, R. M. See Brown, P. D. A comparative study of the cryopres^ acid and of benzoic acid in fish. 24 Casella, L. ervation of human erythrocytes, Burke, M. D. See Doostdar, H. ; Gullotti, M.; Pallanza, G. ghosts and liposomes. 354 Burleigh, M. C. See Briggs, A. D.; Model mono-oxygenase reaction by Breathnach, S. M. Lendon, C. L. binuclear copper(I) complexes in• Epidermal cytokines. 677 Burnet, F. See Disney, G.; Spencer, S. volves an oxygen protonated inter= Bremner, I. See Morrison, J. N. Burton, D. R. See Dransfield, I.; mediate. 821 Briggs, A. D. See Lendon, C. L. Walker, M. R. Casey, A. D. See Corfield, A. P. ; Burleigh, M. C; Lendon, C. L.; Molecular basis of antibody effector Cassaigne, A. See Darriet, M. Born, G. V. R.; Davies, M. J. function. 953 Castell, J. V. Biochemical analysis of individual Bust, C. See Barth, P. T. ; Guillen, M. I.; Marco, V.; Menen= atherosclerotic plaque caps to invest Butterworth, P. J. See Jahan, M.; dez, R.; Nauffal, D.; Gomez-Lechon, tigate susceptibility to rupture. Nakagawa, T. M. J. 1033 ; Jahan, M. Presence of fibronectin fragments in Brindley, D. N. Adjustment to inorganic phosphate bronchoalveolar lavages: an immu- What factors control hepatic triacyl- depletion of the sodium-inorganic noblotting study. 378 glycerol accumulation in alcohol phosphate co-transporter of mouse Castell, S. E. abuse? 251 proximal tubule cells. 353 ; Haiford, S. E. Bristow, H. Buttery, P. J. See Withers, R. M. The role of DNA supercoiling in ; O'Neill, K.; Hannigan, B. M.; Byfield, P. G. H. site-specific recombination by Tn21 McKenna, P. G. ; Copping, S.; Conway, E. resolvase. 760 Leakage of thymidine kinase from Remazol Yellow GGL binding to Castro, J. See Guzman, M. proliferating cells. 55 prealbumin requires an anion. 603 Causey, A. G. See Bartlett, K. Brojer, E. See Merry, A. H. Byrne, D. Cavill, I. See Houston, T. Brooks, S. T. ; Hussey, C; McLoughlin, A. J. Challiss, R. A. J. See Leighton, B. ; Garner, G. V.; Gordon, D. B.; The effect of reactor configuration Chalmers, R. A. See Davies, S. E. C; Marsh, M. N.; Pearson, D. J. on plasmid loss. 193 Mistry, J.; Tracey, B. M. Application of preparative isoelectric Chalmers, R. M. focusing for the isolation of homoge= ; Fewson, CA. neous a-gliadins. 748 Campbell, G. See Hesketh, J. Quantitative immunoblotting in the Brooksbank, R. A. See Jackson, P. J. Campbell, I. C. See Weaver, K. study of bacterial evolution. 153 1104 AUTHOR INDEX

Chambers, T. J. See Hayman, A. R. Processing of thyrotropin-releasing-= ; Sugden, M. C; Palmer, T. N. Chan, M. See Marston, F. A. O. hormone-related peptides in rabbit Ethanol and glucose disposal in the Chan, S. L. F. hypothalamus and prostate. 784 rat. 247 ; Hurst, R. D.; Morgan, N. G. Cohen, G. M. See Stubberfield, C. R. Cramb, G. See Rugg, E. L. Effects of a-adrenergic antagonists Coleman, G. See Al-Ani, B. S. S.; Cranmer, S. See Jefferis, R. on insulin secretion from rat pan= Huntly, P. J.; Sutherland, J. L. Craven, R. P. See Martin, B. T. creatic islets. 1005 Collard, K. J. Creba, J. A. See French, P. J. Chandler, J. See Lace, D. Further studies on the mechanism ; Carey, F.; McCulloch, A. Chang, C. N. See Hitzeman, R. A. by which extracellular sodium de= Metabolism of inositol 1-phosphate Chantry, A. pletion causes 5-hydroxytryptamine in HL60 cells. 557 ; Glynn, P. release from synaptosomes. 803 Crescenzi, K. L. Characterization of a neural protei= Collins, P. See Devery, R.; Lewis, M. ; Foster, K. A.; Williams, A. J. nase which may play a key role in J * Owens D The effect of corticosteroids on the demyelinating disease. 469 Collins, P. B.' See O'Meara, N. incorporation and stimulated release Chapman, J. See Michaelson, D. M. Colyer, J. See Mata, A. M. of arachidonic acid in human leuko= Chapman, J. A. See Murphy, J. A. ; Michelangeli, F.; Lee, A. G.; East, cytes. 279 Charalambous, B. M. See McPherson, J. M. Cresswell, R. C. See Scragg, A. H. M. J. The mechanism of inhibition of the Crompton, M. R. See Moss, S. E. ; McPherson, M. J. calcium-magnesium-ATPase by Cross, A. J. See Stirling, J. M. Multimolecular organization of the monoclonal antibodies. 967 Cross, A. R. bacterial enzyme pullulanase. 722 Conneely, O. M. ; Yea, C. M.; Jones, O. T. G. Charlier, P. See Frere, J. M. ; Dobson, A. D. W.; Carson, M. A.; Inhibition of superoxide generation Charlwood, B. V. Maxwell, B. L.; Tsai, M. J.; Schrad^ by phagocytic leukocytes. 888 ; Brown, J. T. er, W. T.; O'Malley, B. W. Cross, G. A. M. See Menon, A. K. The accumulation of mono- and Structure-function relationships of Cross, R. A. sesquiterpenes in plant cell cultures the chicken progesterone receptor. ; Citi, S.; Kendrick-Jones, J. 61 683 How phosphorylation controls the Chayen, J. See Roberts, J. A. Converse, C. A. See Gregory, C. Y.; self-assembly of vertebrate smooth Chazot, P. L. See Williamson, R. A. Shallal, A. and non-muscle myosins. 501 Chegwidden, W. R. See Shelton, J. Convery, C. M. See Marshall, T. Crossman, A. R. See Augood, S. J. B.; Spencer, I. M. Conway, E. See Byfield, P. G. H. Crouzet, M. See Tuite, M. F. ; Walz, D. A.; Hewett-Emmett, D.; Cook, A. J. See Hurley, P. R. Crumpton, M. J. See Moss, S. E. Tashian, R. E. Cook, E. E. See Preece, J. A. Cunha, G. R. See Higgins, S. J. Active-site modification of chicken Cook, G. A. See Kashfi, K. Cuniiffe, W. J. See Holland, D. B.; carbonic anhydrase III. 974 Cook, M. Kluznik, A. R.; Raxworthy, M. J. Chelliah, J. ; Godenir, N.; Green, F. R.; Stirling, Curtis, C. G. See Richards, S. ; Baum, H. Y.; Meade, T. W.; Humphries, S. E. Curtis, R. See Hussain, A. A. An improved immunoblotting proto= Genetic variation at the fibrinogen Cuthill, S. See Denis, M. col for the characterization of mito• locus is involved in determining Cutler, Rob. L. See Davies, A. M. chondrial antigens. 53 fibrinogen levels: evidence from Czichos, J. Distinguishing antigenic and non-an= thirteen individuals sampled on ; Ehlers, B.; Overath, P. tigenic peptides by generating two repeated occasions. 541 Regulation of variant surface glycol different stains on the same immu= Cooke, A. M. See Taylor, C. W. protein synthesis in Trypanosoma noblot. 149 ; Noble, N. J.; Gigg, R.; Willcocks, brucei. 261 Immunoblot peptide mapping - a A. L.; Strupish, J.; Nahorski, S. R.; novel application to explore the Potter, B. V. L. relationship between mitochondrial Myo-inositol 1,4-bisphosphate-5-= Dalgleish, R. antigens. 151 phosphorothioate: chemical synthe= Collagen gene structure. 661 Chen, C. Y. See Hitzeman, R. A. sis and biochemical properties. 992 Daly, M. See Ball, R. Cheng, K. N. See Tracey, B. M. Cooper, E. H. See Jackson, P. J. ; O'Meara, A.; Murphy, G.; Halli— Cheng, S. See Farooqui, A. A. Cooper, P. J. nan, F. Chisholm, V. See Hitzeman, R. A. ; Danpure, C. J.; Wise, P. J.; Gut= Plasma protein analysis by immunob^ Chitnavis, B. See Evans, R. W. tridge, K. M. lotting. 140 Chittock, R. S. Immunoelectron microscopic localiza= Daly, R. J. ; Wharton, C. W.; Austin, J. C; tion of alanine-glyoxylate aminos ; Manning, D. L.; Green, C. D. Hester, R. E. transferase in normal human liver Estrogen regulated mRNAs in the Resonance Raman studies of glyceral^ and type 1 hyperoxaluric liver. 627 ZR-75-1 human breast cancer cell dehyde-3-phosphate dehydroge^ Cope, G. See Divecha, N. line. 169 nase. 49 Copping, S. See Byfield, P. G. H. Danpure, C. J. See Cooper, P. J.; Cholewinski, A. J. Corcoran, A. E. Mistry, J. ; Wilkin, G. P. ; Smyth, P. P. A. Danson, M. J. See Smith, L. D. Peptide receptors on astrocytes: evi= Polyamines as intracellular messen^ Dihydrolipoamide dehydrogenase: a dence for regional heterogeneity. gers in the human thyroid. 397 'new' function for an old enzyme? 429 Corfield, A. P. 87 Christensen, J. R. ; Clamp, J. R.; Casey, A. D.; Paras= Dark, C. H. See Wali, F. A. ; Smith, G. D.; Peters, T. J. keva, C. Darlison, M. G. See Marshall, J. Characterization of the inhibition of Abnormal secretion of mucus in pre= Darriet, M. See Lacoste, A. M. endosomal insulin degradation. 574 malignant and malignant human ; Basurko, M. J.; Cassaigne, A. Effect of chloroquine on hepatic colonic cells. 581 Interaction of phosphonic substrate insulin-receptor interactions. 1040 Cornwell, T. L. See Lincoln, T. M. analogs with aspartate aminotrans= Christou, G. See Vincent, J. B. Corser, R. See Coughtrie, M. ferase. 611 Chu, L. See Haywood, G. W. Cosstick, R. See Agathocleous, D. C. D'Arrigo, C. See Ferro, V. Citi, S. See Cross, R. A. Cotes, P. M. See Tarn, R. C. Das, A. M. See Carey, F. Clamp, J. R. See Corfield, A. P. Cotter, T. G. See Bradley, J. G. M.; Das, I. See Janah, S. Clare, K. A. See Wessel, W. L. Meagher, L. C. ; De Belleroche, J.; Hirsch, S. Clark, T. R. Coughtrie, M. Thrombin-induced formation of ; Yon, R. J. ; Jackson, M.; Harding, D.; Corser, inositol phosphates by human neu• Partial inactivation of wheat-germ R.; Hume, R.; Burchell, B. trophils. 280 aspartate transcarbamoylase by Molecular probes for human UDP-= Davies, A. M. tetranitromethane. 615 glucuronosyltransferases. 157 ; Cutler, Rob. L.; Smith, M.; Mauk, Clynes, M. See Allan, G. Cowart, M. See Kuchta, R. D. A. G.; Thurgood, A. G. P.; Moore, Coan, R. M. See Mall, A. S. Cox, D. J. See Preece, J. A. G R. Cockcroft, S. See Stutchfield, J. ; Palmer, T. N. Structure of yeast iso-1-cytochrome c Cockle, S. M. The role of skin in glucose disposal in which arginine-38 is replaced by ; Smyth, D. G. on refeeding after starvation. 332 alanine-38. 844 AUTHOR INDEX 1105

Davies, D. S. See Murray, B. P.; Nas= tein E (apo-E)-rich subclass of The amylolytic enzymes of Penicillium seri-Sina, P.; Rich, K. J. plasma high-density lipoproteins, amagasakiense. 181 Davies, M. J. See Briggs, A. D.; Len= HDL-E. 154 Dransfield, I. don, C. L. Devery, R. ; Moir, A. J. G.; Sheth, B.; Burton, Davies, P. See France, T. D. ; Kesserwani, H.; O'Meara, N.; D. R.; Partridge, L. J. ; Rushmere, N. K. Owens, D.; Collins, P.; Johnson, A.; Initial characterization of an anti-ac= Regulatory regions of androgen-re= Tomkin, G. tin monoclonal antibody (NH3). sponsive genes. 695 Effect of chemical sympathectomy 163 Davies, S. E. C. on cholesterol metabolism in rab= Drasar, B. S. See Miller, C. J. ; Chalmers, R. A.; Woolf, D. A.; lies, bits. 201 Draye, J. P. See Van Hoof, F. R. A. Diaz-Mayans, J. J. See Almar, M. Drew, C. See Fletcher, E. J. Betaine metabolism in the human M. Drobniewski, F. A. neonate. 788 Dickens, M. See Tavare, J. M. ; Ellar, D. J. Davies, T. G. E. Dickinson, F. M. See Hill, J. P. Toxin-membrane interactions of ; Thomas, H.; Rogers, L. J. Dickson, A. J. See Fisher, M. J. Bacillus thuringiensis 5-endotoxins. Catabolism of cytochrome f in a Dickson, D. P. E. See Ward, R. J. 39 senescence mutant of Festuca pra= Dickson, G. See Barton, C. H. Duane, P. See Peters, T. J. tensis. 1054 Dideberg, O. See Frere, J. M. Duane, P. D. See Ward, R. J. Davis, B. See Fairclough, A. C; Di Gleria, K. See Bagby, S. Duffy, M. J. See Simon, J. M. Hughes, G. M. Dils, R. R. See Borlakoglu, J. T. Dunbar, B. See McAleese, S. M. Davis, G. See Ryan, J. P. Di Marzo, V. See Garlick, P. B. Duncan, A. See Black, D. Davis, J. R. Disney, G. Duncan, C. J. See McCall, K. E.; ; Lee, E. Y. C; Palmer, T. N. ; Tarbit, M. H.; Burnet, F. Shamsadeen, N. Protein dephosphorylation and hepat= Rat ovarian and human placental Dunkley, P. R. See Thorne, B. ic glycogen synthesis from gluconeo^ aromatases display different sensi= Dunlop, J. See Grieve, A. genie precursors. 579 tivities to inhibition by ketocona= Dunn, M. See King, D. J. Davis, P. D. zole. 29 Dunn, P. P. J. See Gray, J. C. ; Nixon, J. S.; Wilkinson, S. E.; Distefano, M. See Walsh, C. Dunn, R. C. See Miles, C. M. M. Russell, M. G. N. Divecha, N. ; Schachter, M.; Miles, C. M. M.; Inhibition of phospholipase A2 by ; Peat, D.; Mansouri, H.; Cope, G.; Feher, M. D.; Bruckdorfer, K. R.; some long chain alkylamines. 816 McDonald, C. J. Sever, P. S. Dawes, E. A. See Haywood, G. W. Processing of tissue proline-rich Low density lipoproteins increase Dawes, N. J. See McCormack, J. G. proteins after secretion from mouse intracellular calcium in human Day, I. N. M. See Hooper, C. M. parotid glands. 798 platelets. 287 Molecular analysis of two general Dobson, A. D. W. See Boyhan, A.; Duty, S. markers of neurons and the diffuse Conneely, O. M. ; Weston, A. H. neuroendocrine system: neuron— Docherty, M. See Watton, J. The biochemical regulation of potas— specific enolase and PGP9.5. 454 Dolly, J. O. See Ashton, A. C; Wads= sium channels. 532 ; Allsopp, M. T. E. P.; Moore, D. C. worth, J. D. F. Dwek, R. A. See Ferguson, M. A. J. M.; Thompson, R. J. Donnelly, W. See Mehra, R. Dyer, T. A. See Gray, J. C. Aspects of the higher order structure Donohue, M. See Brown, P. D. of the human neuronal marker Dooley, M. See Allan, G. PGP9.5, and of its structural gene. Doostdar, H. Eady, R. R. See Barker, P. D. 323 ; Melvin, W. T.; Burke, M. D.; Earl, C. See Macdonald, A. G. Day, P. See Shaw, W. V. Grant, M. H. Eason, S. Day, P. J. Mixed function oxidation in human ; Carville, D.; Strain, J. J.; Hanni= ; Lewendon, A.; Shaw, W. V. HEP G2 hepatoma cells. 801 gan, B. M. Coenzyme-A-binding site of chloram= Doran, M. The influence of dietary carbohydrate phenicol acetyltransferase. 715 ; Reen, D. J. on antibody-mediated immunity in Dean, C. J. See Tuzi, N. L. Analysis of complement activation copper deficiency. 54 De Beileroche, J. See Das, I.; Rattray, products in biological fluids using East, J. M. See Colyer, J.; Mata, A. M.; Reed, L. J. Polyacrylamide gel electrophoresis. M. Deegan, J. See King, G. F. 160 Eaton, C. L. See France, T. D. De Gier, J. Dorey, C. Eaton, S. J. See Tezapsidis, N. The use of liposomes in the search ; Simpson, R. J.; Willson, R.; Pe= Eccles, C. J. See Gray, J. C. for an understanding of the signifi= ters, T. J. Edwards, H. C. See Moss, S. E. cance of membrane lipid diversity. Use of irradiation inactivation to Edwards, K. See Ashton, A. C. 912 investigate intestinal iron absorption Edwards, P. A. See Preedy, V. R. De la Garza, M. See Kunau, W. H. by isolated brush-border vesicles in Edwards, P. A. W. See Bradbury, J. De la Torre, R. See Murray, B. P. vitro. 832 M. Delgado, C. Dormer, R. L. See Shori, D. K. Edwards-Webb, J. D. See Borlakoglu, ; Francis, G. E.; Fisher, D. Dorr, A. W. J. T. Immunoaffinity cell partitioning of ; Grob, R.; Nicholls, I.; Stace, B. C; Ehlers, B. See Czichos, J. erythrocytes. 968 Winkler, M. A.; Wiseman, A.; Un= Ekins, R. P. See Ruiz de Elvira, M. C. De Meester, I. See Hendriks, D. der wood, B. Elder, G. H. See Llewellyn, D. H. Dempsey, T. See Jones, S. A. The effect of oxygen on the produce El Jamil, A. S. See Salim, M. L. Denis, M. tion of cytochrome P-450 by Sac= Ellar, D. J. See Drobniewski, F. A. ; Wikstroem, A. C; Cuthill, S.; charomyces cerevisiae. 370 Elliott, A. C. See Brown, P. D. Joernvall, H.; Gustafsson, J. A. Doshi, M. See Hussain, A. A. Elliott, G. E. P. Interaction of the glucocorticoid Douglas, A. J. See Beattie, R. E. The place of biochemistry in courses receptor with the Mr ^ 90 000 heat ; Mulholland, G.; Walker, B.; Guth= in physical sciences. 508 shock protein. 688 rie, D. J. S.; Elmore, D. T.; Murphy, Elliott, R. J. See McGrath, L. T. Denton, R. M. See McCormack, J. G.; R. F. Ellis, R. J. Rutter, G. A.; Tavare, J. M. The preparation of a C-terminal ; Robinson, C; Van der Vies, S. M.; De Nucci, G. gastrin peptide containing a syn= Kirwin, P. M. Eicosanoids and skin. 680 thetic B-bend mimetic. 175 Processing and assembly of chloro= Depledge, M. ; Yasui, A.; Walker, B.; Magee, D. plast proteins. 703 ; Rowling, P. J. E.; Raxworthy, M. F.; Murphy, R. F. Ellory, J. C. See Barker, G. A.; Hall, J. Preparation and biological activity of A. C; Harvey, C. M.; Odoom, J. E. The effect of mitomycin-C on dermal indole-3-propionyl-L-leucyl-L-as= Ellul, H. See Armstrong, F. A. equivalent contraction by mouse partyl-phenethylamide: a C-termi= Elmore, D. T. See Backwell, F. R. C; 3T3 fibroblasts. 328 nal gastrin analog. 628 Beattie, R. E.; Douglas, A. J. Desai, K. Dowbenko, D. See Hitzeman, R. A. Elmore, M. See Lynskey, E. ; Owen, J. S. Doyle, E. M. Elmore, M. A. Human platelets bind the apolipopro= ; Kelly, C. T.; Fogarty, W. M. ; O'Cuinn, G. 1106 AUTHOR INDEX

On the subcellular location of particu• Faure, F. See Pauplin, Y. Folting, K. See Vincent, J. B. late luliberinase activity in guinea Fawcett, J. Ford, G. C. See Hannon, R. A.; Smith, pig brain. 209 ; Smith, G. D.; Peters, T. J. J. M. A. El-Saleh, S. C. See Hong, H. Ethanol inhibits endocytosis of insulin Forrow, S. M. A. See Stubberfield, C. Emson, P. C. See Augood, S. J.; Seto-= in perfused rat liver. 573 R. Oshima, A. Effect of fasting on the hepatic pro= Forster, S. See Bird, S. J. Endre, Z. H. See Allis, J. L. cessing of insulin. 1041 ; Scarlett, L.; Lloyd, J. B. ; Allis, J. L.; Ratcliffe, P. J.; Leding= Feher, M. D. See Dunn, R. C. Effects of a lysosomotropic detergent ham, J. G. G.; Radda, G. K. Feizi, T. on cystinotic fibroblasts. 43 Nuclear magnetic resonance studies Oligosaccharides in molecular recogni= Foster, J. R. See Rich, K. J. of rubidium-87(l+) transport in tion. 930 Foster, K. A. See Crescenzi, K. L. perfused rat kidney. 596 Fennelly, J. See Lannon, B. Fothergill-Gilmore, L. A. See McA= Engel, P. C. See Lilley, K. S. Ferguson, M. A. J. leese S IvI England, P. J. See Murray, K. J.; ; Homans, S. W.; Dwek, R. A.; Ra= Foulds, W. S. See Gregory, C. Y. Unitt, J. F. demacher, T. W. Fowler, M. W. See Scragg, A. H. A comparison of the regulation of The glycosylphosphatidylinositol Fox, W. R. See Lindsay, R. M. vascular and cardiac muscle. 503 membrane anchor of Trypanosoma Foxall, P. A. See Miller, C. J. Etcheverry, T. See Hitzeman, R. A. brucei variant surface glycoprotein. Fraher, J. See Manning, J. M. Etherington, D. J. See Maciewicz, R. 265 France, T. D. A. Ferguson, S. J. See Carr, G.; McE= ; Phillips, M. E. A.; Eaton, C. L.; Evans, C. W. See Ferro, V. wan, A. G. Davies, P. Evans, R. W. See Lindley, P. F. Ferguson-Smith, M. A. See Stefani, Regulation of prostatic growth. 389 ; Meilak, A.; Aitken, A.; Patel, K. L. A. J. Francis, G. E. See Delgado, C. J.; Wong, C.; Garratt, R. C.; Chit= Ferrando, M. D. See Almar, M. M. Francis, P. T. See Palmer, A. M. navis, B. Ferrero, M. E. Freedman, R. B. See Barth, P. T.; Characterization of the amino acid ; Marni, A.; Gaja, G. Paver, J. L.; Sugrue, R.; Wilson, M. change in a transferrin variant. 834 Possible enhancement of endothelial J. ; Ogwang, W. cell function induced by defibrotide ; Hawkins, H. C; Murant, S. J.; Interaction of indium with transfer- 540 Reid, L. rin. 833 Ferrie, R. M. Protein disulfide-isomerase: a homo= Evanson, J. M. See Taylor, D. J. ; Skidmore, C. J. log of thioredoxin implicated in the Evered, D. F. Structure and expression of the rab• biosynthesis of secretory proteins. Some landmarks in the history of bit /3-casein gene. 623 96 transamination in animals. 600 Ferro, V. Freeman, A. ; D'Arrigo, C; Ogden, D.; Evans, C. ; Boobis, A. R.; Gooderham, N. J. W. Hepatotoxicity of carbon tetrachlo^ Fabregat, I. See Lorenzo, M. Blotting analysis of adhesive proteins: ride: protection by pretreatment of Fagan, T. an evaluation of the technique using mice with polyriboinosinic acid«poly= ; Mayhew, S. G. B16F 10 malignant melanoma cells. ribocytidylic acid. 632 Effects of mercurials on hydrogenase 144 French, P. J. from Desulfovibrio vulgaris (Hilden^ Fewson, C. A. See Baker, D. P.; Chal= ; Bunce, C. M.; Brown, G.; Creba, borough). 178 mers, R. M. J. A.; Michell, R. H. Fairbrother, W. J. Figueiredo, H. See Malcolm, A. D. B. Inositol phosphates in growing and ; Hall, L.; Littlechild, J. A.; Walker, Fincham, D. A. differentiating HL60 cells. 985 P. A.; Watson, H. C; Williams, R. ; Mason, D. K.; Kwong, F. Y. P.; French, R. C. J. P. Young, J. D. ; Herbert, K. E.; Scott, D. L.; Per= Probing the 3-phosphoglycerate-=: Harmaline inhibition of amino acid rett, D. binding site of yeast phosphoglycer= transport in human and in horse Effect of penicillamine on luminol-= ate kinase using site-specific mu= erythrocytes. 567 dependent chemiluminescence in tants and proton nuclear magnetic Fish, N. M. human leukocytes. 891 resonance spectroscopy. 724 ; Hoare, M. French, T. J. See Sugden, M. C. Fairclough, A. C. Recovery of protein inclusion bodies. Frere, J. M. ; Davis, B.; Johnson, D.; Loxley, P.; 102 ; Joris, B.; Dideberg, O.; Charlier, Mills, J.; Bolton, A. E. Fisher, D. See Delgado, C. P.; Ghuysen, J. M. Beneckea natriegens as an ideal or= Fisher, M. J. See Taylor, D. S. Penicillin-recognizing enzymes. 934 ganism for teaching basic microbial ; Dickson, A. J. Frerman, F. E. physiology in schools. 767 Epidermal growth factor mimics the Acyl-CoA dehydrogenases, electron Fallowfield, C. effects of insulin on phenylalanine transfer flavoprotein and electron ; Lawrie, K. W. M.; Saunders, D.; hydroxylation in isolated liver cells. transfer flavoprotein dehydrogenase Ife, R. J.; Keeling, D. J. 897 416 Photoaffinity inactivation of the Fisher, P. A. Freshney, R. I. See Woods, M. D. gastric (proton-potassium)-ATPase ; Smith, D. E. Fuller, B. J. See Horton, R. A. at a site involved in ion transloca= Affinity purification of antibodies Funk, W. See Burch, A. M. tion. 823 using antigens immobilized on solid Farooqui, A. A. supports. 134 ; Cheng, S.; Rammohan, K.; Kolat= Fitton, J. E. See Wilson, M. J. Gabbott, P. A. tukudy, P.; Horrocks, L. A. Fitzgerald, M. X. See Mcllgorm, E. Core biochemistry required for the Purification, characterization and A.; Power, C. biological sciences undergraduate. cDNA cloning of bovine brain dia= Fitzpatrick, S. C. 511 cylglycerol lipase. 293 ; McKenna, T. J. Gacesa, P. See Lace, D. Faruque, S. M. Dopamine inhibits aldosterone bio= Gaja, G. See Ferrero, M. E. ; Antoniou, M.; Skidmore, C. J. synthesis in vitro. 387 Galione, A. G. The fine structure of the mouse Fitzsimons, E. J. See Houston, T. ; Berridge, M. J. casein gene. 624 Flavell, K. J. See Hughes, M. S. Pharmacological modulation of oscil= ; Skidmore, C. J. Flecknell, P. A. See Kozlowski, U. M. lations in the blowfly salivary gland Transcription unit of the mouse Fletcher, E. J. 988 ai-casein gene. 1064 ; O'Shaughnessy, C. T.; Drew, C; Gallagher, T. F. See Harmey, J. Faulkner, A. Zeman, S.; Lodge, D. Galpin, I. J. See Agathocleous, D. C. ; Pollock, H. T. Effects of phencyclidine-like drugs Galt, J. See Stefani, L. A. J. Interregulation of volatile and long-= on rubidium-86 efflux from rat Gang, K. A. chain fatty acid metabolism in cortical synaptosomes. 200 ; Huggins, J. P. ovine hepatocytes. 203 Fogarty, W. M. See Behan, J.; Doyle, Characterization of membrane frac= Pathways of propionate metabolism E. M.; Kelly, C. T.; McCarthy, J.; tions produced from pulmonary to glucose in ovine hepatocytes. O'Mahony, M. R. artery by two methods which sepa^ 204 rate sarcolemma from sarcoplasmic reticulum. 356 AUTHOR INDEX 1107

Gannon, F. See Keaveney, M.; Nestor, Studies on the neurochemistry and Grob, R. See Dorr, A. W. P. neurophysiology of experimental Gruetter, M. G. See Priestie, J. P. Garcia, M. L. See Kaczorowski, G. J. vitamin E deficiency. 466 Guern, J. See Renaudin, J. P. Garcia Martinez, P. See Livingstone, Goulding, N. J. Guest, J. R. See Andrews, S. C; Spiro, D. R. ; Guyre, P. M. S. Gardiner, R. M. See Kasanicki, M. A. Impairment of erythrocyte-antibody Guillen, M. I. See Castell, J. V. Gariani, L. S. rosette formation by human lipocor= Gullick, W. J. See Tuzi, N. L. ; Malthouse, J. P. G. tin 1 on human leukocytes. 730 Gullotti, M. See Casella, L. Biosynthesis of isotopically enriched Gower, D. B. See Kwan, T. K.; Ren- Guo, L. H. See Barker, P. D. L-serine. 179 nie, P. J.; Watson, D. Gustafsson, J. A. See Denis, M. Garlick, P. B. Gower, H. J. See Barton, C. H. Guthrie, D. J. S. See Douglas, A. J. ; Mashiter, G. D.; Di Marzo, V.; Graham, A. M. See Herrick, A. L. Guttridge, K. M. See Cooper, P. J. Tippins, J. R.; Morris, H. R.; Mais= Graham, C. A. See McLean, W. H. I. Guyre, P. M. See Goulding, N. J. ey, M. N. Graham, M. N. Guzman, M. Synthesis, release and action of leu3 ; Mantle, T. J. ; Castro, J.; Maquedano, A. kotrienes in the isolated rat heart. Kinetic properties of a derepressed Alteration of hepatic carnitine palmi= 361 /3-lactamase from Enterobacter toyltransferase I activity and sensi- Garlick, P. J. See Preedy, V. R. cloacae. 404 tivity to malonyl-CoA in adaptation Garner, G. V. See Brooks, S. T. Grand, R. J. A. to ethanol consumption. 649 Garratt, R. C. See Evans, R. W.; Lind- Intracellular calcium receptor mecha= ley, P. F. nisms in muscle and nerve. 520 Garrido, A. See Bautista, J. M. Grant, C. M. See Tuite, M. F. Haase-Pettingell, C See King, J. Garton, A. J. See Small, C. A. Grant, D. Hadley, A. G. See Merry, A. H. Gaston, S. J. S. See Marshall, T. ; Long, W. F.; Williamson, F. B. Hahne, S. See Nilsson, O. Gehl, K. A. See Hall, A. C. Heparans as pericellular antioxidants Haigh, J. R. George, S. J. See Armstrong, F. A. 977 ; Phillips, J. H. Gerhart, M. J. See Reed, B. Y. A model of calcium-heparin interact Demonstration of a sodium/hydrogen Gershoni, J. M. tion. 1028 exchange activity in the bovine Protein-blot analysis of receptor-lig- Polystyrene surfaces may require adrenal chromaffin granule mem3 and interactions. 138 structured water for effective cell brane. 595 Ghuysen, J. M. See Frere, J. M. adhesion. 1029 Haigh, M. See Scott, J. E. Gibbons, W. A. See Wessel, W. L. Effect of heparin on dismutation of Halestrap, A. P. See Poole, R. C. Gibbs, P. J. See Preedy, V. R. superoxide ions. 1030 Halford, S. E. See Castell, S. E.; Par3 Gibson, A. See Lauffart, B. Grant, D. A. W. See Sharma, R. J. ker, C. N. Gibson, A. M. See McDermott, J. R. Grant, G. See Santoro, L. G. Hall, A. C. Gigg, R. See Cooke, A. M. ; Watt, W. B.; Stewart, J. C; Bar= ; Gehl, K. A.; Urban, J. P. G.; Ello3 Gilani, A. H. See Saeed, S. A. docz, S.; Pusztai, A. ry, J. C. Gillies, D. R. B. Intestinal and pancreatic responses Potassium transport in isolated bo- ; Marshall, R. D. to dietary soybean (Glycine max) vine articular chondrocytes. 637 Renal osmomodulin: the likely physi- proteins. 610 Hall, L. See Fairbrother, W. J. ological role of Tamm-Horsfall Grant, M. E. Hall, N. A. glycoprotein. 547 ; Ayad, S. ; Patrick, A. D. Gilliland, D. See Marshall, T. The collagens of skin: structure and Analysis of dolichol-linked oligosac- Gitomer, W. L. assembly. 663 charides in brains from patients ; Veech, R. L. Grant, M. H. See Doostdar, H. with Batten's disease. 1031 Effect of acetate on hepatic inorganic Gray, J. C. Hall, R. D. See Holden, M. A. ion content. 577 ; Dunn, P. P. J.; Eccles, C. J.; Hallett, M. B. See Zhang, L. Gladwin, A. M. Green, R. M.; Hird, S. M.; Hoglund, Hallinan, F. See Ball, R.; Daly, M. ; Ward, J. B.; Martin, J. F.; Booth, A. S.; Webber, A. N.; Willey, D. L.; Haipin, C. See Lord, J. M. R. F. G. Dyer, T. A. Hamm, J. Inhibition of monocyte Chemotaxis The chloroplast genome and the ; Scherly, D.; Mattaj, I. W. by monoclonal antibodies recognize biogenesis of the chloroplast thyla= Small nuclear RNA-protein complex- ing cell surface differentiation anti• koid membrane. 704 es. 943 gens. 966 Green, A. K. See Taylor, D. S. Hammer, J. L. See Zhang, H. Gleeson, M. A. See Sudbery, P. E. Green, A. R. See Stirling, J. M. Han, K. K. See Pauplin, Y. Glynn, P. See Chantry, A. Green, C. D. See Daly, R. J. Hanlon, S. E. B. See Armstrong, F. Godenir, N. See Cook, M. Green, F. R. See Cook, M. A. Godson, C. Green, R. M. See Gray, J. C. Hann, A. C. See Lace, D. ; Ryan, M. P. Green, S. R. See Prescott, C. D. Hannigan, B. M. See Bristow, H.; Effects of gentamicin on the calcium Greenidge, E. See Wali, F. A. Eason, S. and polyphosphoinositide metabolism Gregory, B. See Allan, G. Hannon, R. A. of rat renal brush border membrane Gregory, C. Y. ; Ford, G. C. vesicles. 213 ; Converse, C. A.; Foulds, W. S. Analysis of lattice contacts in protein Goldberg, A. See Houston, T. Effect of glycosaminoglycans on rod crystals. 961 Goldfarb, P. See Jafelice, L. R. S. outer segment phagocytosis by Hanson, P. J. See Atwell, M. M.; Goldstein, B. M. retinal pigment epithelium explants Hatt, J. F. ; Bell, J. E.; Marquez, V. E. 319 Hardcastle, A. J. See Arden, G. B. Dehydrogenase binding by cofactor Gregson, N. A. See Johnson, A. R. Harding, C R. See Richards, S. analogs. 862 Greiling, H. See Stoecker, G. Harding, D. See Coughtrie, M. Gomez-Lechon, M. J. See Castell, J. Grieve, A. Hargreaves, I. See Spencer, I. M. V. ; Dunlop, J.; Griffiths, R. Harkness, R. A. See Wajner, M. Goodchild, M. G. See Shod, D. K. Inhibition of high-affinity synaptoso= Harmer, I. Goode, A. W. See Jin, D. Y.; Sugden, mal uptake of D-aspartate in rat ; Jefferis, R. M. C. brain by L- and D-enantiomers of Structural and idiotypic relationships Gooderham, N. J. See Freeman, A.; excitatory sulfur-containing amino between monoclonal antibodies Watson, H. A.; Woodman, A. C. acids. 302 specific for IgGl Fc epitopes. 747 Goodwin, T. W. Griffin, M. M. See Steven, F. S. Harmey, J. The origins and development of bio= Griffiths, J. R. See Stubbs, M. ; McLoughlin, K.; Gallagher, T. F. chemistry in the U.K. 507 Griffiths, R. See Grieve, A. Photoregulation of transcription of Gordon, D. B. See Brooks, S. T. Griffiths, S. A. See Blair, G. E. chloroplast genes. 711 Gordon-Weeks, P. R. See Taylor, J. ; Blair, G. E. Harmey, M. A. See Stuart, R. A. Gore, M. See Perry, N.; Spencer, P. Immunochemical analysis of myelin Harpur, E. S. See Lazenby, C. M. Gorinsky, B. See Lindley, P. F. proteins of the rat central nervous Harrington, M. C. Goss-Sampson, M. A. system. 614 ; Henehan, G. T. M.; Tipton, K. F. ; Muller, D. P. R. The interrelationships of alcohol 1108 AUTHOR INDEX

dehydrogenase and the aldehyde hoof, G.; Schärpe, S.; Yaron, A. Metabolic channelling of phospholi3 dehydrogenases in the metabolism Dipeptidyl peptidase IV activity in pids formed through serine base of ethanol in liver. 239 stimulated T lymphocytes. 365 exchange for secretion by rat hepa3 Harrington, M. G. See Salim, M. L. ; Verkerk, R.; Vanhoof, G.; De tocytes. 1036 Harrison, L. M. Meester, I.; Van Sande, M.; Schärpe, Hitzeman, R. A. ; Sinnett-Smith, P. A. S. ; Chang, C. N.; Chen, C. Y.; Singh, Circulating insulin concentrations Release of the carboxyterminal argi3 A.; Etcheverry, T.; Chisholm, V.; and lipogenesis in inbred lines of nine from atriopeptin II by human Kohr, W.; Vehar, G.; Renz, M.; mice differing in fatness. 1037 plasma carboxypeptidase N. 359 Dowbenko, D. Harrison, P. M. See Andrews, S. C; Henehan, G. T. M. See Harrington, Protein products from yeast. 1081 Smith, J. M. A.; Thomas, C. D. M. C. Hoare, M. See Fish, N. M. Harrison, P. R. See Llewellyn, D. H. Hepp, E. See Kempen, H. J. Hockmeyer, W. T. See Richards, R. Harrison, T. J. See Miller, C. J. Herbert, K. E. See French, R. C. L. Hartley, D. L. Hermon-Taylor, J. See Hurley, P. Hodges, N. A. See Brearley, C. A. ; Kane, J. F. R.; Winterbourne, D. J. Hodgins, M. B. Properties of inclusion bodies from Heron, J. R. M. See Carey, F. ; Rowney, D. A. recombinant Escherichia coli. 101 Herrick, A. See Houston, T. Regulation of the human skin fibrob3 Harvey, C. M. Herrick, A. L. last androgen receptor by andro3 ; Ellory, J. C. ; Thompson, G. G.; Graham, A. M.; gens. 172 Stoichiometry of taurine transport McColl, K. E. L.; Medley, L; Moore, Hodgson, I. by the B-system in pigeon erythro3 M. R. ; Malcolm, A. D. B. cytes. 555 Effects of some antidepressant drugs Distribution of the ATTT sequence Harwood, J. L. See Jones, A. L.; Lew• on rat hepatic 5-aminolevulinate in the 3'-untranslated region of is, R. W.; Walker, K. A. synthase. 847 human and mouse genes. 366 Hasnain, S. S. See Lindley, P. F. Herschkowitz, N. See Carey, E. M. Hodgson, J. A. Hassman, R. See Stott, D. I. Hesketh, J. ; James, G.; Batayneh, N.; Lindsay, Hathaway, D. R. ; Campbell, G.; McKenzie, N. J. G. ; Adam, L. P.; Turner, R. C; Lash, Both insulin and cholera toxin in3 Biosynthesis of precursor forms of J. A. crease 1,2-diacylglycerol synthesis the pyruvate dehydrogenase complex Myosin light chain and heavy chain in 3T3 fibroblasts. 283 and mitochondrial phosphate trans3 phosphorylation in smooth muscle: Hester, R. E. See Chittock, R. S. porter in Saccharomyces cerevisiae. potential regulatory roles for calci3 Hewett-Emmett, D. See Chegwidden, 776 um, phospholipids and cyclic nu3 W. R. ; Torrance, M. R.; Neagle, J.; Lind3 cleotides. 499 Heywood, B. R. say, J. G. Hatt, J. F. ; Rajam, S. R.; Birchall, J. D.; Lipoyl groups in mammalian pyruvate ; Hanson, P. J. Mann, S. dehydrogenase complex: time-de3 Novel pathways inhibiting histamine Crystallochemical recognition at pendent desensitization towards stimulation of the cyclic AMP con3 organized inorganic-organic inter3 N-ethylmaleimide. 775 tent of rat isolated parietal cells. faces. 824 Hoeoeg, J. O. See Joernvall, H. 808 Heywood-Waddington, D. Hoglund, A. S. See Gray, J. C. Hawkins, H. C. See Barth, P. T.; ; Sutherland, I. A.; Peters, T. J. Holan, G. See Lummis, S. C. R. Freedman, R. B. Sub-fractionation of rat liver micro3 Holden, M. A. Hawksworth, G. M. See Pennington, somes by two-polymer phase parti3 ; Hall, R. D.; Yeoman, M. M. J. tion in a toroidal coil centrifuge. Limitations to product yield in rapid3 Haworth, D. See Carey, F. 34 ly growing cultures of Capsicum Hawthorne, J. N. Hickman, J. A. See Thompson, M. G. frutescens. 66 Phosphoinositides and metabolic Hider, R. C. See Barlow, D. J. Holland, D. B. See Raxworthy, M. J.; control: how many messengers. Higgins, J. A. See Hitchin, B. W. Wood, E. J. 657 Higgins, S. J. ; Cunliffe, W. J.; Wood, E. J.; Turn3 Hayashi, M. See Hunt, A. ; Young, P.; Cunha, G. R. er, D. M. Hayes, L. J. Tissue-specific gene expression during Effect of 1-a-hydroxyvitamin D3 on ; Wright, D. J. M.; Archard, L. C. reprogramming of reproductive epidermal keratins in psoriasis. Segmented genome of Borrelia dutto3 tract epithelium. 810 331 nii. 544 Higgs, E. A. See Moncada, S. Holland, K. T. See Rennie, P. J. Hayman, A. R. Hill, C. R. See Marston, F. A. O. Holmgren, A. ; Warburton, M. J.; Chambers, T. Hill, H. A. O. See Bagby, S.; Barker, Thioredoxin and glutaredoxin: small J. P. D. multi-functional redox proteins Characterization of an acid collage3 Hill, J. P. with active-site disulfide bonds. 95 nase from human osteoclastomas. ; Dickinson, F. M. Holness, M. J. See Sugden, M. C. 1064 Pre-steady-state kinetics of aldehyde ; Sugden, M. C. ; Warburton, M. J.; Pringle, J. A. oxidation by pig liver cytosolic Hyperthyroidism impairs skeletal S.; Chambers, T. J. aldehyde dehydrogenase. 856 muscle glycogen repletion after Tartrate-resistant acid phosphatase. Steady-state kinetics of aldehyde refeeding. 554 Purification and characterization of oxidation by pig liver cytosolic Is there a role for pyruvate dehydro3 the human osteoclastoma enzyme. aldehyde dehydrogenase. 857 genäse in the re-activation of hepat3 895 Hill, M.J. See Wait, R. ic pyruvate dehydrogenase complex Haynes, N. B. See Withers, R. M. Hill, P. M. after re-feeding?. 773 Hayre, M. D. See Richards, R. L. Postgraduate education in biomedical Homans, S. W. See Ferguson, M. A. Hayter, A. P. See Wali, F. A. sciences: a New Zealand perspec3 J. Haywood, G. W. tive. 120 Hombrados, I. See Pauplin, Y. ; Anderson, A. J.; Chu, L.; Dawes, Hinchliffe, E. Hong, H. E. A. The genetic improvement of brewing ; El-Saleh, S. C; Johnson, P. Accumulation of polyhydroxyalka3 yeast. 1077 Effects of calcium on the fluorescence noates by bacteria and the substrate Hipkiss, A. R. See Monks, N.J. properties of chicken gizzard calpain specificities of the biosynthetic Hipps, D. S. II. 1045 enzymes. 1046 ; Murphy, G. Hooper, C. M. Headon, D. R. See Allan, G.; Boyhan, Studies on human fibroblast gelati3 ; Allsopp, M. T. E. P.; Day, I. N. A.; Power, R. F. nase. 893 M. Heffron, J. J. A. Hirata, M. See Ito, T. Derivation and application of comple3 Monitoring and assessment of a re3 Hird, S. M. See Gray, J. C. mentary DNA probes for human search student's project. 118 Hirsch, S. See Das, I. neuron specific and muscle specific Heizmann, C. W. See Seto-Oshima, Hitchcock, C. A. See Othman, Y. H. enolase: epitope prediction and A. S. genomic structure. 305 Hendriks, D. Hitchin, B. W. Hooper, N. M. ; De Meester, I.; Umiel, T.; Van3 ; Higgins, J. A. ; Turner, A. J. AUTHOR INDEX 1109

Detergent solubilization of phosphati- Huntly, P. J. dase and lignin peroxidase in the dylinositol-anchored ectoenzymes. ; Coleman, G.; Munro, A. L. S. exocellular fluid of a stationary 583 A comparative study of the sera of phase culture of Phanerochaete Hornby, D. P. See Lilley, K. S. brown trout (Salmo trutta) and chrysosporium. 369 Horrocks, L. A. See Farooqui, A. A. Atlantic salmon (Salmo salar L.) by Jahan, M. See Butterworth, P. J. Horsfall, A. C. Western blotting against Aeromonas ; Pollard, J. W.; Butterworth, P. J. ; Venables, P. J. W.; Mumford, P. salmonicida exoproteins. 999 Hormonal regulation of mouse uterine A.; Allard, S. A.; Maini, R. N. Hurley, P. R. alkaline phosphatase. 848 Distribution of idiotypes in human ; Cook, A. J.; Austen, B. M.; Her3 James, G. See Hodgson, J. A. autoimmune disease. 341 mon-Taylor, J. James, H. M. Horton, R. A. Antibodies to trypsinogen activation ; Nicholas, G. A.; Smith, C. A.; ; Rice-Evans, C; Fuller, B. J. peptides recognize both calcium-de• Sweetman, A. J. Temperature-mediated suppression pendent and calcium-independent A colorimetric microvolume assay for of oxidant stress in kidney cell epitopes. 337 nucleoside diphosphatase activity membranes. 20 Hurst, R. D. See Chan, S. L. F. in Golgi membrane preparations. Hortsch, M. See Paver, J. L. Husain, O. A. N. See Roberts, J. A. 561 Hothi, S. K. See Jones, C. G. Hussain, A. A. See Willmott, N. J. Janah, S. Hough, D. W. See Smith, L. D. ; Doshi, M.; Curtis, R.; Voaden, M. ; Das, I. Houslay, M. D. See Kilgour, E. J. Variations in phagocyte chemilu- Houston, T. Progressive retinal atrophy in the minescence. 289 ; Fitzsimons, E. J.; Cavill, I.; Tibetan terrier: studies on cyclic Janson, L. McColl, K. E. L.; Thompson, G. G.; GMP and taurine homoeostasis. ; Bell, E. Herrick, A.; Moore, M. R.; Goldberg, 317 Involvement of an arginine residue A. Hussain, S. T. in glutamate dehydrogenase with Biochemical investigation of hepa- ; Muwalla, M.; Hunaiti, A. R.; Bay3 the 1-position carboxyl of gluta3 toerythropoietic porphyria-homozy- doun, E. mate. 860 gous porphyria cutanea tarda. 829 Histochemical localization of 5'-nu- Jarvis, S. M. See Williams, T. C. ; Fitzsimons, E. J.; Moore, M. R. cleotidase activity in Awassi sheep Jefferis, R. See Harmer, I.; Walker, A simple reversed phase high per• (Ovis asiatica) placenta. 1042 M. R. formance liquid chromatographic Hussey, C. See Byrne, D.; Licken, B.; ; Cranmer, S.; Arata, Y.; Takahashi, method for the separation of heme, Newell, M. N. protoporphyrin and iron. 831 Hutton, D. A. See Mall, A. S. Glycosylation heterogeneity in human Hovik, R. See Osmundsen, H. ; Allen, A.; Slayter, H. S. IgG subclass proteins. 340 Howard, T. D. Studies on pig gastric mucins by Jeffery, D. See Rutherford, D. M. ; Barber, J.; Lian, L. Y.; Tebb, G. electron microscopy. 584 Jeffery, S. See Carter, N. Inhibition of elongation factor Tu by Jenkins, S. A. See Preedy, V. R. the antibiotic kirromycin. 761 Jenkins, T. M. Howell, R. M. See Williams, R. Ife, R. J. See Failowfield, C. ; Weitzman, P. D. J. Howell, S. L. See Bjaaland, T. Ikuta, T. See Yoshida, A. Metabolic roles of succinate thioki— Hsu, L. C. See Yoshida, A. lies, R. A. See Davies, S. E. C. nase. 795 Huckle, K. R. See Burke, A. B. Illidge, T. M. See Moreland, B. H. Jepson, M. A. See Lawrence, G. M. Huffman, J. C. See Vincent, J. B. Imanaka, T. See Lazarow, P. B. Jhoti, H. See Lindley, P. F. Huggins, J. P. See Gang, K. A. Inayat, M. S. Jiang, M. J. See Morgan, K. G. Hughes, A. E. See McLean, W. H. I. ; Mattey, M. Jin, D. Y. See Sugden, M. C. Hughes, G. M. Regulation of NADP+-specific glycer3 ; Goode, A. W.; MacLennan, P. A.; ; Davis, B.; Spencer, I. M. ol dehydrogenase in Aspergillus Sugden, M. C. Lipase and esterase activity during niger by bicarbonate ions. 976 Delayed inactivation of tissue pyru= microcycle growth of Aspergillus Irons, J. See Thome, B. vate dehydrogenase complex in niger. 790 Islam, K. response to increased fatty acid Utilization of carbon substrates dur= ATP-induced fluorescence decline availability in the fed state. 553 ing microcycle growth of Aspergillus and phosphorylation of the light—— Joernvall, H. See Denis, M. niger. 791 harvesting chlorophyll a/b binding ; Hoeoeg, J. O.; Von Bahr-Lind3 Hughes, K. T. See Palmer, S. protein complex (LHC-II) protein stroem, H.; Johansson, J.; Kaiser, Hughes, M. S. See Partridge, S.; at low and high ATP concentra• R.; Persson, B. Thomas, G. M. H. tions. 46 Alcohol dehydrogenases and aldehyde ; Flavell, K. J.; Birch, N. J. Ito, T. dehydrogenases. 223 Transport of lithium into human ; Hirata, M.; Kitamura, K.; Kuriya- Johansson, J. See Joernvall, H. erythrocytes as studied by lithium-7 ma, H. Johnson, A. See Devery, R.; Owens, nuclear magnetic resonance and Roles of myo-inositol 1,4,5-trisphosp3 D. atomic absorption spectroscopy. hate and myo-diacylglycerol in Johnson, A. H. See O'Meara, N. 827 vascular smooth muscles as second Johnson, A. R. ; Thomas, G. M. H.; Partridge, S.; messengers: in relation to actions ; Gregson, N. A.; Wigley, C. B.; Birch, N. J. of acetylcholine. 488 Berry, M. An investigation into the use of a Iwanejko, L. A. The regeneration of adult rat retinal dysprosium shift reagent in the ; Stewart, G. S. A. B. ganglion cell axons in vitro. 440 nuclear magnetic resonance spec- Cloning in Escherichia coli of a DNA Johnson, D. See Fairclough, A. C. troscopy of biological systems. 207 sequence with translational fidelity Johnson, M. See Mitchell, R. Hughes, W. M. to the known protein sequence for Johnson, P. See Allen, M. J.; Hong, ; Paul, F. E.; Matthews, I. T. W.; Clostridium perfringens sporulation H.; Zhang, H. Barnwell, S. G.; Keogh-Bennett, J.; specific enterotoxin. 1069 Johnson, R. ML See Lincoln, T. M. Taylor, P. W. Izgu, F. See Tuite, M. F. Johnston, G. A. R. See Lummis, S. C. Quantification of low density lipopro3 R. tein receptors on HepG2 cells by Johnstone, A. See Whitley, G. fluorescence activated cell sorting. Jackson, J. B. See McEwan, A. G. ; Whitley, G.; Nussey, S. 363 Jackson, M. See Coughtrie, M. Immortalization of human thyrocytes Hughes-Jones, N. C. See Merry, A. Jackson, P. J. by transfection. 197 H. ; Turner, R.; Keen, J. N.; Brooks- Jones, A. L. Hume, R. See Coughtrie, M. bank, R. A.; Cooper, E. H. ; Harwood, J. L. Humphries, S. E. See Cook, M. Evidence for a human uteroglobin-- Effects of heavy metals on lipid me3 Hunaiti, A. R. See Hussain, S. T. like protein occurring in the urine tabolism in marine algae. 275 Hunt, A. See Seaton, P. of patients with renal failure. 970 Jones, C. G. ; Hayashi, M.; Seaton, P.; Patel, A. Jacobs, V. N. See Masters, D. J. ; Hothi, S. K.; Titheradge, M. A. J. Jafelice, L. R. S. Effect of dexamethasone on pyruvate Influence of nerve cells on the devel- ; Wiseman, A.; Goldfarb, P. carboxylation and decarboxylation opment of astrocytes. 295 Sequential appearance of ß-glucosi3 in isolated hepatocytes from starved rats. 1075 1110 AUTHOR INDEX

Jones, J. See Patel, B. N. Kemp, G. J. labelled substrates for the measure• Jones, J. G. See Jones, S. A. ; Khodja, D.; Bevington, A.; Russell, ment of ketone body turnover in Jones, K. M. R. G. G. the same experimental animal. 736 ; Baron, A. J.; Wootton, J. C.; Functional compartmentation of Ketone body turnover in rats during McPherson, M. J. cellular orthophosphate in human acute treatment with 2[6(4-chloro- Site-directed mutagenesis studies of erythrocytes revealed by phospho- phenoxy) hexyl] oxirane-2-carboxy 1- Escherichia coli glutamate dehydro• rus-32 labeling. 781 ate (etomoxir). 797 genase. 874 Kempen, H. J. Krishnamurthi, S. Jones, O. T. G. See Cross, A. R. ; Lommerse, E.; Van Schie, R.; ; Patel, Y.; Joseph, S.; Kakkar, V. Jones, P. See Lauf fart, B. Hepp, E.; Meyer, P.; Princen, H. V. Jones, P. M. See Bjaaland, T. Bile acid synthesis by human hepato• Selective desensitization of protein-3 Jones, R. ma cell line Hep-G2 is stimulated kinase-C-mediated platelet granule ; Lancaster, R. T. by low density lipoprotein. 566 secretion with prolonged incubation Carbohydrate-binding activity of Kendall, G. of protein kinase C activators de3 mammalian sperm proacrosin; an ; Ashall, F.; Miles, M. A.; Kelly, J. spite sustained 45 kDa phosphoryla3 unusual property of a serine protei3 M. tion. 804 nase. 1035 Genes encoding glyceraldehyde-3-3 Kubal, G. See Bell, J. D. Jones, S. A. phosphate dehydrogenase in Trypa3 Kuchta, R. D. ; Dempsey, T.; Jones, J. G.; Rice-3 nosoma cruzi. 1067 ; Cowart, M.; Allen, D.; Benkovic, Evans, C. Kendrick-Jones, J. See Cross, R. A. S. J. Oxygen radicals, iron and erythrocyte Keogh-Bennett, J. See Hughes, W. Kinetic and structural investigations filterability. 292 M. of the replicative fidelity of the Jordan, P. M. See Alwan, A. F.; War3 Kerr, M. A. Klenow fragment. 947 ren, M. J. ; Albrechtsen, M.; Yeaman, G. R. Kumpel, B. M. See Merry, A. H. Joris, B. See Frere, J. M. Characterization of the IgA receptor ; Leader, K. A.; Bradley, B. A. Joseph, S. See Krishnamurthi, S. from human neutrophils. 731 The relationship between IgG sub3 Jutla, J. See Ward, R. J. Kesserwani, H. See Devery, R. class and Gm allotype of monoclon3 Khan, J. A. See Salih, S. G. al anti-Rh(D) antibodies and their Khandelwal, R. L. See Sohal, P. S. functional activity. 733 Kaczorowski, G. J. Khodja, D. See Kemp, G. J. Kunau, W. H. ; Slaughter, R. S.; Garcia, M. L.; Khodr, H. ; Buehne, S.; De la Garza, M.; Kion3 King, V. F. ; Moore, G. R.; Strike, A. J.; Wil3 ka, C; Mateblowski, M.; Schultz-3 The role of sodium-calcium exchange liamson, D. J. Borchard, U.; Thieringer, R. in excitable cells. 529 Solid-state and solution-state phos- Comparative enzymology of /3-oxida3 Kaiser, R. See Joernvall, H. phorus-31 nuclear-magnetic-reso• tion. 418 Kakkar, V. V. See Krishnamurthi, S. nance studies of the hemoglobin-in- Kundaiker, S. See Arden, G. B. Kalsheker, N. See Swanson, T. ositol hexaphosphate complex. 839 Kuo, Y. M. See Yesufu, H. M. I. Kalsheker, N. A. See Llewellyn, D. Kikkawa, U. See Shearman, M. S. Kuonen, D. R. H. Kikuchi, I. See Yoshida, A. ; Roberts, P. J. Kane, J. F. See Hartley, D. L. Kilgour, E. Solubilization of a glutamate-binding Kardasz, A. M. See Langlands, J. M. ; Anderson, N. G.; Houslay, M. D. protein from brain membranes. Karimi, S. J. See Saeed, S. A. Activation of the "dense-vesicle' cyclic 446 Karplus, P. A. See Schulz, G. E. AMP-phosphodiesterase from rat Kuriyama, H. See Ito, T. Karr, G. See Moran, E. liver by cyclic AMP-dependent Kwan, T. K. Kasanicki, M. A. protein kinase. 1025 ; Perumal, R.; Gower, D. B. ; Gardiner, R. M.; Baldwin, S. A. King, D. J. Pregnenolone metabolism in testicu3 Reconstitution of the bovine brain ; Walton, F.; Smith, B. W.; Dunn, lar preparations of Macaca fascicu3 microvessel glucose transport protein M.; Yarranton, G. T. laris. 1003 into large unilamellar vesicles by a Recovery of recombinant proteins Effect of oxytocin on testicular steroi3 rapid extrusion technique. 352 from yeast. 1083 dogenesis in the macaque (Macaca Kashfi, K. King, G. F. See Odoom, J. E. fascicularis). 1004 ; Weakley, L. J.; Cook, G. A. ; Deegan, J.; Smith, R.; Matous3 Kwong, F. Y. P. See Fincham, D. A. Effects of diabetes on the carnitine chek, A.; Campbell, I. D. palmitoyltransferase of isolated A nuclear magnetic resonance study hepatic mitochondrial outer mem• of alamethicin-, ö-hemolysin-, and Lace, D. branes. 1010 melittin-induced sodium leakage ; Chandler, J.; Hann, A. C; Olaves3 Kauppinen, R. See McMahon, H. T. from large unilamellar vesicles. 594 en, A. H.; Gacesa, P. Kavanagh, K. A. King, J. Immunocytochemical labeling of ; Whittaker, P. A. ; Haase-Pettingell, C. hyaluronidase in bovine sperm. The effect of cell recycle batch fer3 Aggregate formation from thermola- 643 mentation on ethanol production bile intermediates in the maturation Lackey, D. by Pachysolen tannophilus and of the thermostable P22 tailspike. ; Malcolm, A. D. B. Candida shehatae. 198 105 Role of human T-cell ribonuclease in Kay, I. See McAleese, S. M. King, M. T. See Reed, B. Y. lymphokine gene expression. 367 Kearney, J. N. See Rowling, P. J. E. King, V. F. See Kaczorowski, G. J. Lacoste, A. M. Keaveney, M. Kionka, C. See Kunau, W. H. ; Darriet, M.; Neuzil, E.; Le Goffic. ; Neilan, J.; Gannon, F. Kirk, C J. See Barker, C. J. F. An analysis of the genomic structure Kirwin, P. M. See Ellis, R. J. Inhibition of alanine racemase by of the 3' untranslated region of the Kitamura, K. See Ito, T. vinylglycine and its phosphonic human estrogen receptor gene. 388 Kluznik, A. R. analog: a proton nuclear magnetic Keeling, D. J. See Fallowfield, C. ; Cunliffe, W. J. resonance spectroscopy study. 606 Keen, J. N. See Jackson, P. J. Keratin biosynthesis in the piloseba- Lamb, J. See Mehlert, A. Keen, P. See Nielsch, U. ceous ducts in acne patients. 330 Lambert, P. H. See Stott, D. I. Kekwick, R. G. O. See Sheldon, P. S. Knox, P. See Rigg, H.; Tanner, V. Lancaster, R. T. See Jones, R. Kelly, C. T. See Behan, J.; Doyle, E. Kohr, W. See Hitzeman, R. A. Lane, A. C. See Lynn, A. G. M.; McCarthy, J.; O'Mahony, M. R. Kolattukudy, P. See Farooqui, A. A. Lang, D. See Lewis, M. J. ; Fogarty, W. M. Korczyn, A. D. See Michaelson, D. Langlands, J. M. Bacterial a-glucosidases - a reclassifi3 M. ; Kardasz, A. M.; Rodger, I. W.; cation. 184 Kosaka, Y. See Shearman, M. S. Watson, J. Kelly, D. E. See Kelly, S. L. Kowal, A. See Toth, C. A. Lack of turnover of inositol phos3 Kelly, J. M. See Kendall, G. Kozlowski, U. M. phates in guinea pig and rat lung Kelly, S. L. ; Aynsley-Green, A.; Flecknell, P. parenchyma may be due to its de3 ; Kelly, D. E. A.; Bartlett, K. pendence on extracellular calcium Analysis and exploitation of cyto• Two independent methods using during contraction. 35 chrome P-450 in yeast. 1086 radioactive and stable isotopically AUTHOR INDEX 1111

Lannon, A. M. See Armstrong, F. A. Lian, L. Y. See Howard, T. D. Llewellyn, D. H. Lannon, B. Licken, B. ; Urquhart, A.; Scobie, G.; Elder, ; O'Kennedy, R.; Fennelly, J. ; McLoughlin, A. J.; Hussey, C. G. H.; Kalsheker, N. A.; Harrison, The production and characterization Factors influencing the expression P. R. of monoclonal antibodies to leukem• and maintenance of recombinant Molecular analysis of acute intermit• ic cells. 376 Plasmids in Bacillus subtilis. 194 tent porphyria. 799 Larkin, S. See Martin, F. Lieber, C. S. Llewelyn, J. G. See Patel, N. J. Lash, J. A. See Hathaway, D. R. The microsomal ethanol oxidizing Lloyd, A. J. Lau, K. R. See Brown, P. D. system: its role in ethanol and ; Weitzman, P. D. J. Lauffart, B. See Biggins, J. A. xenobiotic metabolism. 232 Purification and characterization of ; McDermott, J.; Gibson, A.; Man• Metabolic effects of acetaldehyde. NAD-linked isocitrate dehydroge• tle, D. 241 nase from Methylophilus methylo- Purification and characterization of Lightly, E. R. T. See Bird, I. M. trophus. 871 leucine aminopeptidase from human Lilley, K. S. Lloyd, A. W. See Brearley, C. A. cerebral cortex. 850 ; Engel, P. C. Lloyd, J. B. See Bird, S. J.; Förster, ; McDermott, J.; Jones, P.; Mantle, Identification of three essential lysine S. D. residues probably involved in sub• Lo, W. W. Y. Amino acid inhibition of aminopepti- strate binding of the NAD+-depend= Receptor activation, G-protein and dases purified from human cerebral ent glutamate dehydrogenase of second-messenger cross-talk in cortex. 849 Clostridium symbiosum. 875 human pituitary clonal cells. 437 Laurent, G. J. See Mays, P. K. ; Hornby, D. P.; Engel, P. C. Lockhart, B. P. Lavandero, S. Purification, chemical modification ; Smith, T. P.; Bailey, C. J. ; Puente, J.; Sapag-Hagar, M. and analysis of pH-dependence of The binding of epidermolytic toxin Enzymic activities in rat lactating the NADP+-dependent glutamate to epidermal cells. 334 mammary gland after pre-gestation- dehydrogenase of Escherichia coli. Lodge, D. See Fletcher, E. J. al sialoadenectomy. 778 876 Logan, A. Lawrence, G. M. Lim, S. P. See Bolton, T. B. ; Logan, S. D. ; Beesley, A. C. H.; Jepson, M. A.; Lima, V. L. M. Fibroblast growth factor stimulates Matthews, J. B. ; Mclntyre, N.; Owen, J. S. phosphoinositide hydrolysis in Endogenous 6-phosphogluconate Secretion of lecithinxholesterol acyl- Balb/c 3T3 fibroblasts in vitro. dehydrogenase and the biochemical transferase (LCAT) by the human 987 and histochemical quantification of hepatoma cell line, HepG-2. 155 Logan, S. D. See Logan, A.; McDer• hexokinase. 867 Lincoln, T. M. mott, E. E. Lawrie, K. W. M. See Fallowfield, C. ; Cornwell, T. L.; Rashatwar, S. S.; Lommerse, E. See Kempen, H. J. Lawson, D. M. See Thomas, C. D. Johnson, R. M. Long, M. T. Lazarow, P. B. Mechanism of cyclic-GMP-depend- ; Steel, C. C; Mercer, E. I. ; Small, G. M.; Imanaka, T. ent relaxation in vascular smooth Location of squalene accumulation Biogenesis of enzymes of peroxisomal muscle. 497 and physiological effects of ergoster- ß-oxidation. 410 Lindley, P. F. ol depletion in naftifine-grown Lazenby, C. M. ; Evans, R. W.; Garratt, R. C; Go- yeast. 1044 ; Harpur, E. S. rinsky, B.; Hasnain, S. S.; Jhoti, H.; Long, W. F. See Grant, D. Effects of neomycin on potassium Sarra, R.; Walton, A. R. Lord, J. M. transport into inside-out erythrocyte Structural studies on transferrins: ; Halpin, C. membrane vesicles. 598 the anion-binding sites. 825 Formation of protein bodies and Lea, R. G. Lindros, K. See Carter, N. glyoxysomes. 706 ; Bolton, A. E. Lindsay, J. G. See Hodgson, J. A. Lorenzo, ML An immunosuppressive factor from Lindsay, R. M. ; Fabregat, I.; Roncero, C; Benito, equine placental tissue. 793 ; Baty, J. D. M. Leach, S. A. See Wait, R. A comparison of the acetylation of Fetal rat brown adipocyte primary Leader, K. A. See Kumpel, B. M. sulfamethazine in vitro by whole cultures: characterization of a system Ledeboer, A. M. See Sudbery, P. E. blood and washed red blood cells for lipid synthesis studies. 274 Ledingham, J. G. G. See Endre, Z. H. from healthy and diabetic human Low, M. G. Lee, A. G. See Colyer, J.; Mata, A. M.; subjects. 786 Glycosylphosphatidylinositol: an Michelangeli, F.; Munkonge, F. M. ; Baty, J. D.; Fox, W. R.; Willis, R. anchor for eukaryotic membrane Lee, D. Y. See Palmer, S. G. proteins. 271 Lee, E. Y. C. See Davis, J. R. The use of gas chromatography-mass Lowe, P. A. See Marston, F. A. O.; Legisa, M. See Mattey, M. spectrometry to study transacetyla- Sugrue, R. Le Goffic, F. See Lacoste, A. M. tion by human whole blood in vitro. Lowe, S. See Mattey, M. Legon, S. See Augood, S. J. 742 Lowe, S. L. See Palmer, A. M. Leighton, B. Use of gas chromatography-mass Lowe, V. J. See Bagby, S. ; Lozeman, F. J.; Challiss, R. A. J.; spectrometry to study deacetyla— Loxley, P. See Fairclough, A. C. Newsholme, E. A. tion-reacetylation of arylamides by Lozeman, F. J. See Leighton, B. Effects of glucocorticoid treatment of whole blood in vitro. 743 Lucy, J. A. See Ahkong, Q. F. rats in vivo on insulin sensitivity of ; Fox, W. R.; Baty, J. D. Luisi, B. F. See Nagai, K. soleus and extensor digitorum lon- Acetylation of aniline and phenetidine Lummis, S. C. R. gus muscles in vitro. 174 in vitro by human whole blood. ; Sattelle, D. B.; Johnston, G. A. Lendon, C. L. See Briggs, A. D. 1071 R.; Holan, G. ; Briggs, A. D.; Born, G. V. R.; ; McLaren, A. M.; Baty, J. D. Insecticide action on GABAergic Burleigh, M. C.; Davies, M. J. Effect of hemolysis on the acetylation chloride flux in insect central nerv• Mechanical testing of connective of p-aminobenzoic acid by human ous system. 303 tissue in the search for determinants whole blood and washed erythro• Lundqvist, T. See Nilsson, O. of artherosclerotic plaque cap rup= cytes in vitro. 1024 Lunt, G. G. See Brown, M. C. S.; Mar• ture. 1032 Littlechild, J. A. See Fairbrother, W. shall, J.; Rutherford, D. M.; Thorne, Lewendon, A. See Day, P. J.; Shaw, J. B. W. V. Littleton, J. M. Lydon, J. See Boyhan, A. Lewis, G. P. See O'Neill, L. A. J. Alcohol-induced alterations in calcium Lynch, C. See Martin, F. Lewis, M. J. handling. 527 Lynham, J. A. See Murray, K. J. ; Collins, P.; Lang, D. Livingstone, D. R. Lynn, A. G. Endothelium-derived relaxing factor, ; Garcia Martinez, P.; Stegeman, J. ; Lane, A. C; Smeaton, L. A. calcium and inositol phosphates. J.; Winston, G. W. A semiautomated method for the 486 Benzo[a]pyrene metabolism and determination of pepsin activity in Lewis, R. W. aspects of oxygen radical generation gastric juice using the Tecan liq• ; Richards, R. J.; Harwood, J. L. in the common mussel (Mytilus uid-handling system. 26 Surfactant metabolism: the role of edulis L.). 779 Lynskey, E. specific apoproteins. 276 ; Elmore, M.; O'Cuinn, G.; O'Con- 1112 AUTHOR INDEX

nor, B. Maciewicz, R. A. the sequence 5' to the initiation Studies on an angiotensin-converting ; Etherington, D. J. codon. 48 enzyme of guinea pig brain. 191 Enzyme immunoassay for cathepsins B Malcolm, A. D. B. See Hodgson, I.; Lyons, P. A. and L in synovial fluids from pa3 Lackey, D.; Rahman, K.; Voss, U. ; Wise, P. H.; Palmer, T. N. tients with arthritis. 812 B. The polyol pathway in the human ; Wardale, R. J.; Etherington, D. J. ; Figueiredo, H. erythrocyte and its response to Studies on the activation mechanism Non-radioactive probes in Southern diabetes. 363 for the precursor to cathepsin L. blots. 139 1056 Malhotra, R. Mcllgorm, E. A. ; Reid, K. B. M.; Sim, R. B. McAleese, S. M. ; Power, C; O'Connor, C. M.; Fitz3 Studies on the isolation of human ; Dunbar, B.; Kay, I.; Fothergill-Gil3 gerald, M. X. Clq-receptor. 735 more, L. A. Elastase and collagenase in the bron3 Mali, B. Cofactor-independent monophospho3 choalveolar lavage fluid of sarcoid ; Nicholas, P. C. glycerate mutase. 558 patients. 390 Jaffe's reaction for creatinine: spec3 McAnulty, R. J. See Mays, P. K. Mcllwain, H. trophotometric characteristics of McCall, K. E. The Biochemical Journal and the the production of the reaction be3 ; Duncan, C. J. Journal of Neurochemistry as agents tween glucose and alkaline picrate. Factors affecting creatine kinase exemplifying and fostering biochem3 393 release in soleus muscle. 1052 istry and neurochemistry during Jaffe's reaction for creatinine: spec3 McCarthy, J. their initial years of publication. trophotometric study of the product ; Kelly, C. T.; Fogarty, W. M. 599 of the reaction of creatinine, glucose Preliminary studies on the amylolytic Maclntyre, D. E. See Rossi, A. G. and alkaline picrate. 394 system of the anaerobe Clostridium Mclntyre, N. See Lima, V. L. M. Jaffe's reaction for creatinine: kinetic butyricum. 184 McKenna, P. G. See Bristow, H. study of the reactions of creatinine, McColl, K. E. L. See Herrick, A. L.; McKenna, T. J. See Fitzpatrick, S. C. glucose and creatinine and glucose Houston, T. McKenzie, F. R. with alkaline picrate. 395 McConnell, D. J. See Shields, D. ; Mullaney, I.; Unson, C. G.; Spie3 Jaffes' reaction for creatinine: kinetic McCormack, J. G. See Unitt, J. F. gel, A. M.; Milligan, G. study and spectrophotometric char3 ; Dawes, N. J. The use of anti-peptide antisera to acteristics of the product of the Effects of barium(2-l-) ions on the probe interactions between receptors reactions of creatinine, acetoacetate intramitochondrial calcium-sensitive and guanine nucleotide binding and creatinine and acetoacetate dehydrogenases of rat heart and proteins. 434 with alkaline picrate. 549 liver mitochondria. 590 MacKenzie, I. See Bolton, T. B. A spectrophotometric study of the ; Denton, R. M. McKenzie, N. See Hesketh, J. behavior of bilirubin in solutions of The regulation of mitochondrial Mackenzie, S. M. See Morris, G. E. sodium hydroxide. 550 function in mammalian cells by Maclachlan, N. A. See Berry, R. M. Jaffes' reaction for creatinine: spec3 calcium ions. 523 McLaren, A. M. See Lindsay, R. M. trophotometric and kinetic study of McCulloch, A. See Creba, J. A. McLean, W. H. I. bilirubin in the reaction. 551 McDermott, E. E. ; Graham, C. A.; Hughes, A. E.; Malik, Z. ; Logan, S. D. Nevin, N. C. ; Bottomley, R.; Austen, B. The anticonvulsant carbamazepine Rabbit antiserum against proteins Allergenicity of the major genetic and inositol lipid hydrolysis in rat secreted by human fibroblasts. 375 variants of bovine /?-lactoglobulin. hippocampus. 986 McLennan, A. G. See Agathocleous, 338 McDermott, J. See Lauffart, B. D. C; Taylor, G. E. Mail, A. S. McDermott, J. R. See Biggins, J. A. MacLennan, P. A. See Jin, D. Y.; ; Hutton, D. A.; Coan, R. M.; Sell3 ; Gibson, A. M.; Biggins, J. A. Sugden, M. C. ers, L. A.; Allen, A. Peptidases involved in the degrada3 McLoughlin, A. J. See Byrne, D.; Gastric mucins: different size of tion of neurotensin by human brain Licken, B.; Newell, M. subunit according to reducing condi3 synaptic membranes. 851 McLoughlin, K. See Harmey, J. tions. 585 Macdonald, A. G. McMahon, H. T. Mallet, A. I. See Rennie, P. J. ; Earl, C. ; Kauppinen, R.; Nicholls, D. G. Malthouse, J. P. G. See Gariani, L. S. Preliminary measurements of the Energetics of calcium-dependent Mangnall, D. phase transition in liposomes of glutamate release from synapto3 ; Beresford, J.; Prescott, A. di-(n-methyl-)~hexadecanoylphosp3 somes and the effect of experimen3 Partial purification of a tyrosyl pro3 hatidylcholine (n = 3,4) using dila3 tal anoxia, hypoglycemia and ische3 tein kinase from rat liver cytosol by tometry and fluorescence polariza• mia. 880 affinity chromatography on poly3 tion. 348 McMillan, R. M. See Masters, D. J.; (Glu:Tyr)-linked Sepharose 4B. ; Wahle, K. W. J. Rossi, A. G. 780 Use of the fluorescent probe pyrene McPherson, M. A. See Shori, D. K. Mann, S. See Heywood, B. R.; Ward, to measure the effects of exogenous McPherson, M. J. See Charalambous, R. J. fatty acids on the fluidity of micro3 B. M.; Jones, K. M. Manning, D. L. See Daly, R. J. somes. 349 ; Charalambous, B. M. Manning, J. M. McDonald, C. J. See Divecha, N. Functional analysis of the starch ; Fraher, J. McEnroe, M. See Mehra, R. debranching enzyme pullulanase. Effects of heating on the extracellular McEwan, A. G. 723 matrix in muscle. 169 ; Richardson, D. J.; Jackson, J. B.; McSheehy, P. M. J. Mansouri, H. See Divecha, N. Ferguson, S. J. ; Bashford, C. L. Mantle, D. See Biggins, J. A.; Lauf3 The periplasmic nitrate reductase Gossypol, a cytoxic agent, may uncou3 fart, B. and trimethylamine-N-oxide reduc3 pie respiration of Ehrlich ascites Mantle, T. J. See Boyce, S. J.; Gra3 tase of the photosynthetic bacterium tumor cells. 616 ham, M. N.; Rigney, E. M. Rhodobacter capsulatus. 182 Maddy, A. H. See Wu, Z. Maquedano, A. See Guzman, M. Macey, M. See Veys, P. A. Magee, D. F. See Douglas, A. J. Marabani, M. See Black, D. Macgillvray, R. T. A. See Burch, A. Maier, H. See Steven, F. S. Marco, V. See Castell, J. V. M. Maini, R. N. See Horsfall, A. C. Marison, I. W. McGrath, L. T. Maisey, M. N. See Garlick, P. B. ; Von Stockar, U. ; Elliott, R. J. Makinde, V. Fermentation control and the use of Lipid distribution in the media of ; Wali, F. A. calorimetry. 1091 the human thoracic aorta. 164 Toxicity of atracurium measured by Marni, A. See Ferrero, M. E. McGregor, A. M. See Stott, D. I. lactate dehydrogenase assay in rat Marquez, V. E. See Goldstein, B. M. McGuinness, M. isolated hepatocytes. 614 Marr, G. See Thomas, G. M. H. ; Smyth, H. Makoff, A. J. Marsden, D. See Augood, S. J. Trypsin effect on the lipid bilayer: ; Smallwood, A. E. Marsh, M. N. See Brooks, S. T. characterization of released vesicles Heterologous expression in Escheric3 Marshall, J. 189 hia coli: effects of alterations in ; Darlison, M. G.; Lunt, G. G.; Bar3 AUTHOR INDEX 1113

nard, E. A. Matthews, J. B. See Lawrence, G. M. Middleton, B. See Middleton, A. Cloning of putative nicotinic acetyl• Matthews, N. See Swanson, T. Miles, C. M. M. See Dunn, R. C. choline receptor genes from the Mauk, A. G. See Burch, A. M.; Davies, ; Schachter, M.; Dunn, R. C; Sever, locust. 463 A. M. P. S. Marshall, J. H. A. See Smith, T. A. Mauk, M. See Burch, A. M. Oleic acid stimulates phosphoinositide Marshall, R. D. See Gillies, D. R. B. Maxwell, B. L. See Conneely, O. M. turnover in human platelets. 288 Marshall, T. May, F. E. B. See Wiseman, L. R. Miles, M. A. See Kendall, G.; Rossell, ; Convery, C. M.; Williams, K. M. Mayes, P. A. See Mindham, M. A. R. J. Electrophoresis and silver staining of Mayhew, S. G. See Fagan, T. Millburn, P. See Burke, A. B.; Seym3 the proteins of wool and specialty Mayor, S. See Menon, A. K. our, M. A. fibers. 639 Mays, P. K. Miller, C. J. ; Gaston, S. J. S.; Williams, K. M. ; McAnulty, R. J.; Laurent, G. J. ; Foxall, P. A.; Harrison, T. J.; Electrophoresis and silver staining of Age-related changes in heart collagen Drasar, B. S. the proteins of unconcentrated metabolism. 749 Vibrio cholerae hemolysin: genetic beer. 167 Meade, T. W. See Cook, M. constitution and biotype. 638 ; Gilliland, D.; Williams, K. M. Meagher, L. Miller, N. E. See Mindham, M. A. Sodium dodecyl sulfate/polyacrylam3 Development of the neutrophil de3 Miller, P. G. G. ide gel electrophoresis of milk pro• granulation response. 128 Courseware for teaching computer-3 teins: application to cheese. 165 Meagher, L. C. based sequence analysis to under3 ; Williams, K. M. ; Cotter, T. G. graduate molecular biologists. 764 Turbidimetric response of aqueous HL-60 cells as model myeloid progen3 Milligan, G. See McKenzie, F. R. protein and detergent to trichloroa3 itors. 400 Mills, D. See Murray, K. J. cetic acid. 640 Meats, J. E. See Best, L. Mills, J. See Fairclough, A. C. Marston, F. A. O. See Sugrue, R. Meda, P. See Anner, B. M. Millward, D. J. See Yahya, Z. A. H. ; Angal, S.; Lowe, P. A.; Chan, M.; Medley, I. See Herrick, A. L. Milner, R. E. Hill, C. R. Mehlert. A. ; Trayhurn, P. Scale-up of the recovery and reacti• ; Lamb, J.; Young, D. Acute effects of cold on GDP binding vation of recombinant proteins. Analysis of stress-related proteins and uncoupling protein concentra3 112 involved in the immune response to tion in brown adipose tissue mito3 Marston, S. mycobacterial infection. 721 chondria of genetically obese (ob/3 ; Pritchard, K.; Redwood, C; Tag3 Mehra, R. ob) mice. 1009 gart, M. ; McEnroe, M.; Donnelly, W. Milner-White, E. J. Calcium regulation of the thin fila3 Quantification of lactoferrin in bovine 7-Turns as loop motifs in proteins. ments: biochemical mechanism milk fractions. 215 50 and physiological role. 494 Meilak, A. See Evans, R. W. Mindham, M. A. Marston, S. B. See Pritchard, K.; Meiling, J. See Wadsworth, J. D. F. ; Mayes, P. A.; Miller, N. E. Taggart, M. J. Melvin, W. T. See Doostdar, H. Evaluation of reverse cholesterol Martin, B. T. Menendez, R. See Castell, J. V. transport in the isolated perfused ; Betteridge, A.; Craven, R. P. Menon, A. K. rat spleen. 282 Regulation of gonadotropin biosyn3 ; Schwarz, R. T.; Mayor, S.; Cross, Mistry, J. thesis in the rat anterior pituitary G. A. M. ; Danpure, C. J.; Chalmers, R. A. by gonadoliberin and androgens. Glycolipid precursor of Trypanosoma Hepatic D-glycerate dehydrogenase 170 brucei variant surface glycoproteins: and glyoxylate reductase deficiency Martin, F. incorporation of radiolabeled man3 in primary hyperoxaluria type 2. ; Treacy, M.; Schuster, W.; Lynch, nose and myristic acid in a cell-free 626 C; Larkin, S.; Tait, S.; Whelan, J. system. 996 Mitchell, C. H. See Arden, G. B. Hormonal and tissue-specific control Mercer, E. I. See Long, M. T.; Steel, Mitchell, R. of rat prolactin and rat growth C. C. ; Johnson, M.; Ogier, S. A. hormone gene expression. 699 Meredith, C. Regulation of receptor-operated Martin, J. F. See Gladwin, A. M. ; Austen, B. calcium influx by protein kinase C. Mashiter, G. D. See Garlick, P. B. Antibody probes to the signal se3 597 Mason, A. N. quence of ovalbumin. 36 Mohandas, T. K. See Yoshida, A. Biochemistry required for the physi3 Merino, J. See Stott, D. I. Moir, A. J. G. See Dransfield, I. cal science undergraduate. 515 Merlevede, W. See Vanden Abeele, C. Moks, T. See Uhlen, M. Mason, D. K. See Fincham, D. A. Merry, A. H. Moncada, S. Mason, R. M. See Williams, S. P. ; Brojer, E.; Zupanska, B.; Hadley, ; Higgs, E. A.; Palmer, R. M. J. Mason, R. W. See Wilcox, D. A. G.; Kumpel, B. M.; Hughes-3 Characterization and biological signif3 Masters, D. J. Jones, N. C. icance of endothelium-derived re3 ; Jacobs, V. N.; Carr, V. J.; McMil3 Comparison of the ability of mono3 laxing factor. 484 lan, R. M. clonal and polyclonal anti-D antibo3 Monks, N. J. Kinetics of 5-lipoxygenase: influence dies to promote the binding of ; Baum, H.; Hipkiss, A. R.; Bittles, of substrate solubility and product erythrocytes to lymphocytes, granu3 A. H. inactivation. 38 locytes and monocytes. 727 Age-dependent growth inhibition of Masterson, B. See Witts, H. Meyer, D. See Paver, J. L. human diploid fibroblasts by 2-de3 Masterson, B. F. See Sagar, K. A.; Meyer, P. See Kempen, H. J. oxyglucose. 617 Scaife, C. Michaelson, D. M. Moore, D. C. M. See Day, I. N. M. Mata, A. M. ; Chapman, J.; Bachar, O.; Korczyn, Moore, G. R. See Burch, A. M.; Dav3 ; Colyer, J.; Tunwell, R. E. A.; Lee, A. D.; Wertman, E. ies, A. M.; Khodr, H. A. G.; East, J. M. Antibodies to a 200 kDa cholinergic Moore, G. W. Effect of monoclonal antibodies raised antigen in Alzheimer's disease. 855 A student's view of postgraduate against calcium-magnesium ATPase Michelangeli, F. See Colyer, J.; Mun3 education. 125 from rabbit skeletal muscle sarco3 konge, F. M. Moore, M. See Walsh, C. plasmic reticulum on ATPase activi3 ; Rooney, E. K.; Lee, A. G. Moore, M. R. See Herrick, A. L.; ty and its correlation with epitope The effects of oleic acid on the activi3 Houston, T. location. 771 ty of the reconstituted calcium-3 Moran, E. Mateblowski, M. See Kunau, W. H. magnesium-ATPase. 347 ; O'Kennedy, R.; Phillips, J.; Karr, Matouschek, A. See King, G. F. Michell, R. H. See Barker, C. J.; G. Mattaj, I. W. See Hamm, J. French, P. J. Production and characterization of Mattey, M. See Inayat, M. S. Middleton, A. monoclonal antibodies to human ; Legisa, M.; Lowe, S. ; Bonser, N.; Middleton, B. brain tumor cells. 373 Effect of lectins and inhibitors on Modulation of low-density lipoprotein Moreland, B. H. membrane transport in Aspergillus binding by cyclic AMP in human ; Illidge, T. M. niger. 969 vascular smooth muscle cells and Effect of dihydroxy-bile salts on the Matthews, I. T. W. See Hughes, W. skin fibroblasts. 1008 interaction of trypsin and trypsin M. inhibitors. 168 1114 AUTHOR INDEX

; Sheerin, N.; Wood, D.; Ayling, C; Murray, S. See Watson, D. Nicholls, I. See Dorr, A. W. Schulster, D. Muwalla, M. See Hussain, S. T. Nicholls, P. J. See Rahman, K. Effects of human growth hormone on Nicholson, D. W. See Stuart, R. A. rat skeletal muscle: increased colla• Nicolau, C. gen production. 177 Nagai, K. Liposomes and erythrocytes as drug Morgan, K. G. ; Thoegersen, H. C; Luisi, B. F. carriers in vivo. 917 ; Brozovich, F. V.; Jiang, M. J. Refolding and crystallographic studies Nielsch, U. Measurements of intracellular calcium of eukaryotic proteins produced in ; Keen, P. concentration in mammalian vascu= Escherichia coli. 108 Changes in tachykinin and actin lar smooth muscle cells during agon= Nahorski, S. R. See Cooke, A. M. gene expression in rat sensory neu• ist-induced contractions. 493 Nakagawa, T. rons after cutting or crushing the Morgan, N. G. See Chan, S. L. F. ; Butterworth, P. J. sciatic nerve. 465 Morreü, D. See Yahya, Z. A. H. Metabolic changes accompanying Nieminen, P. See Carter, N. Morris, A. J. See Barker, C. J. phosphate depletion. 785 Nilsson, O. Morris, G. E. Nasreen, R. See Saeed, S. A. ; Lundqvist, T.; Hahne, S.; Sjoe- ; Mackenzie, S. M.; Nguyen Thi Nasseri-Sina, P. berg, B. M. Man ; Seddon, C. E.; Boobis, A. R.; Dav• Structure-function studies of the Identification of C-terminal epitopes ies, D. S. large subunit of ribonucleotide on creatinine kinase using mono• Cytoprotective effects of 16,16-dime- reductase from Escherichia coli. 91 clonal antibodies. 717 thyl prostaglandin Ei on paraceta• Nishizuka, Y. See Shearman, M. S. Morris, H. R. See Garlick, P. B. mol toxicity in isolated hepatocytes Nixon, J. S. See Davis, P. D. Morris, P. See Scragg, A. H. 641 Noble, N. J. See Cooke, A. M. Morrison, J. N. Nauffal, D. See Castell, J. V. Nock, L. P. ; Wood, A. M.; Bremner, I. Neagle, J. See Hodgson, J. A. ; Thomas, H.; Rogers, L. J. Effects of inflammatory stress on Neale, M. L. See Swanson, T. Mechanisms of chloroplast assembly metallothionein-I concentrations in Neilan, J. See Keaveney, M.; Nestor, and disassembly in Festuca praten= blood cells and plasma of rats. 820 P. sis. 1053 Moss, S. E. Neilson, L. See Stott, D. I. Norman, R. I. See Burgess, A. J. ; Crompton, M. R.; Edwards, H. C; Nestor, P. Nott, D. M. See Preedy, V. R. Crumpton, M. J. ; Neilan, J.; Gannon, F. Nunn, J. D. p68: A new protein of the lipocortin The isolation of chicken and African ; Walker, B.; Williams, C. H. family. 813 green monkey genomic clones for Peptidase activity in mammalian Mueller, G. the estrogen receptor. 388 cerebral cortex. 405 ; Schönstedt, G.; Wiech, H.; Zim= Neupert, W. See Stuart, R. A. Nussey, S. See Johnstone, A.; Whitley, mermann, R. Neuzil, E. See Lacoste, A. M.; Paup= G. Import of proteins into the endo• lin, Y. Nuttall, M. E. plasmic reticulum. 708 Neville, L. F. ; Wallace, H. M. Muhlemann, M. F. See Williams, D. ; Arvin, B.; Roberts, P. J. Uptake of methylglyoxal bis(guanyl= G. Is D-[3H] aspartate a useful tool for hydrazone) by BHK-21/C13 cells. Mulholland, G. See Douglas, A. J. assessing excitatory amino acid 210 Mullaney, I. See McKenzie, F. R. neurotransmitter function? 315 Muller, D. P. R. See Goss-Sampson, Nevin, N. C. See McLean, W. H. I.; M. A. Stefani, L. A. J. Oakey, R. E. See Othman, Y. H. S. Mullins, C. J. See Smith, C. J. New, M. O'Brien, R. M. See Tavare, J. M. Mumford, P. A. See Horsfall, A. C. Congenital adrenal hyperplasia. 691 O'Connell, M. J. See Ward, R. J. Munkonge, F. M. Newby, A. C. ; Ward, R. J.; Baum, H.; Treffry, ; Michelangeli, F.; Lee, A. G. Metabolic vasodilatation: the role of A.; Peters, T. J. Dependence of protein-protein inter• adenosine. 479 Evidence of a biosynthetic link be• actions on the lipid-to-protein Newell, M. tween ferritin and hemosiderin. ratio in reconstituted calcium-mag• ; McLoughlin, A. J.; Hussey, C. 828 nesium ATPase. 346 Effect of gene expression on copy O'Connor, B. See Lynskey, E. Munro, A. L. S. See Huntly, P. J. number and heritable stability of O'Connor, C. M. See Mcllgorm, E. A.; Murad, F. recombinant plasmids in Bacillus Power, C. Role of cyclic GMP in the mechanism subtilis. 192 O'Connor, D. of action of nitrovasodilators, en- Newland, A. C. See Veys, P. A. ; Wilton, D. dothelium-dependent agents and Newsholme, E. A. See Leighton, B. Expression of the mature form of atrial natriuretic peptide. 490 Newton, R. P. See Salih, S. G.; Smith, yeast citrate synthase in Escherichia Murant, S. J. See Freedman, R. B. C. J. coli. 718 Murphy, G. See Daly, M.; Hipps, D. Nguyen Thi Man See Morris, G. E. O'Connor, P. J. See Ryan, A. J. S. Nicholas, G. A. See James, H. M. O'Cuinn, G. See Elmore, M. A.; Lyns= ; Barry, F. Nicholas, P. C. See Mali, B. key, E. Fragmentation of cartilage proteogly• Detection of fructose-1,6-diphosphate O'Donnell, L. See O'Meara, N. cans. 188 aldolase after starch gel electropho• Odoom, J. E. Murphy, J. A. resis: theoretical and practical ; Campbell, I. D.; Ellory, J. C; ; Chapman, J. A.; Rumsby, M. G. considerations. 750 King, G. F. Protein kinase C in astrocyte- and Effects of buffer concentrations, pH, Measurement of peptide transport oligodendrocyte-enriched brain cell triose phosphate isomerase and using proton nuclear magnetic reso= primary cultures: their phorbol glycerol-3-phosphate dehydrogenase nance spectroscopy. 635 ester response. 294 on the measurement of the activity Ogden, D. See Ferro, V. Murphy, R. F. See Beattie, R. E.; of aldolase and glyceraldehyde-3-- Ogier, S. A. See Mitchell, R. Douglas, A. J. phosphate dehydrogenase. 752 Ogita, K. See Shearman, M. S. Murray, B. P. Determination of fructose-1,6-di- Ogwang, W. See Evans, R. W. ; Boobis, A. R.; De la Torre, R.; phosphate aldolase activity with Ohlendieck, K. Segura, J.; Davies, D. S. glyceraldehyde-3-phosphate dehy• ; Ryan, N. M. Inhibition of dietary mutagen activa• drogenase and diformazan forma• Immunocytochemical localization of tion by methylxanthines. 620 tion. 753 calsequestrin in rabbit skeletal Murray, I. A. See Shaw, W. V. Nicholl, D. S. T. See Urwin, N. A. R. muscle. 380 Murray, K. J. Models and simulations in molecular Immunocytochemical localization of ; England, P. J.; Lynham, J. A.; biology. 765 acetylcholinesterase in human skele• Mills, D.; Reeves, M. L. Mapping and sequencing the human tal muscle. 770 Measurement of cyclic-AMP-depend- genome: a model for the future. O'Kennedy, R. See Carroll, K.; Lan• ent protein kinase activity ratio in 766 non, B.; Moran, E. heart by use of a synthetic peptide. Nicholls, D. See Wilkinson, R. Olavesen, A. H. See Lace, D. 355 Nicholls, D. G. See Barrie, A.; McMa- Oldfield, E. hon, H. T. Spectroscopic studies of lipids and biological membranes. 1 AUTHOR INDEX 1115

Olliff, C. J. See Brearley, C. A. elam, M. J. O. Pay, G. F. See Tones, M. A. Olufemi, O. S. Measurement of intracellular inositol Peacock, L. I. L. ; Talwar, D.; Robb, D. A.; Williams, 1,4,5-trisphosphate concentrations ; Wahle, K. W. J. D. in unstimulated and vasopressin-3 Isomeric eis and trans fatty acids Identification of two glycated compo• stimulated rat hepatocytes using a and porcine platelet reactivity to nents present in urine. 29 novel inositol 1,4,5-trisphosphate-3 collagen in vitro. 291 Olufunwa, R. I. See Thomas, G. M. specific binding assay. 991 Pearson, D. J. See Brooks, S. T. H. Palmer, T. N. See Cox, D. J.; Davis, Pearson, J. D. O'Mahony, M. R. J. R.; Lyons, P. A.; Preece, J. A. Purine nucleotides as regulators of ; Kelly, C. T.; Fogarty, W. M. Papahadjopoulos, D. vessel tone. 480 Extracellular ß-galactosidase of Pae3 Liposome formation and properties: Peat, D. See Divecha, N. cilomyces varioti. 183 an evolutionary profile. 910 Pennington, J. O'Malley, B. W. See Conneely, O. M. Paraskeva, C. See Corfield, A. P. ; Scott, A. K.; Reid, I. W.; Hawk3 O'Meara, A. See Ball, R.; Daly, M. Parish, D. C. See Tezapsidis, N. sworth, G. M. O'Meara, N. See Devery, R. Parish, J. H. See Booth, A. G. Changes in rat hepatic UDP-glucuro3 ; O'Donnell, L.; Owens, D.; Collins, Parker, C. N. nosyltransferase activity after indue3 P. B.; Johnson, A. H.; Tomkin, G. ; Halford, S. E. tion of hyper- or hypothyroidism, H. How does resolvase sense the orienta3 are substrate dependent. 802 Lipoprotein cholesterol levels in tion of res sites that are distantly Perham, R. N. hypercholesterolemic rabbits. 200 spaced? 754 ; Berry, A.; Scrutton, N. S. O'Neil, S. Parker, J. R. Flavoprotein disulfide oxidoreductas3 ; Weitzman, P. D. J. ; Wheeler, K. P. es: protein engineering of gluta3 Acinetobacter calcoaceticus isocitrate Proteins present in proteoliposomes thione reductase from Escherichia dehydrogenase - fractionation, containing a sodium-dependent coli. 84 AMP stimulation and hysteretic alanine transporter. 344 Perrett, D. See French, R. C. behavior. 870 Parkhouse, R. M. E. See Paver, J. L. Perry, B. N. O'Neill, K. See Bristow, H. Parodi, A. J. See Bosch, M. ; Savva, D.; Skidmore, C. J. O'Neill, L. A. J. Parr, A. J. See Robins, R. J. Are all growth hormone genes gluco3 ; Lewis, G. P. Partridge, L. J. See Dransfield, I. corticoid responsive? 176 Effect of interleukin-1 on free arachi3 Partridge, S. See Hughes, M. S.; Perry, N. donic acid levels in human synovial Thomas, G. M. H. ; Spencer, P.; Gore, M.; Scawen, cells. 286 ; Hughes, M. S.; Thomas, G. M. H.; M.; Atkinson, T. Effect of antirheumatic drugs on Birch, N. J. Presence of residues in the glycerol interleukin 1 activity in human Lithium transport in erythrocytes. dehydrogenase from Bacillus stear3 synovial cells. 892 205 othermophilus reactive to the reag3 Ong, M. L. Patel, A. J. See Hunt, A.; Seaton, P. ent pyridoxal 5-phosphate. 976 ; Ball, S. G.; Vaughan, P. F. T. Patel, B. N. Persson, B. See Joernvall, H. The effect of cyclic AMP on the ; Jones, J.; Skidmore, C. J. Perumal, R. See Kwan, T. K. inhibition of noradrenaline release, Effect of inhibitors of ADP-ribosyla3 Peters, T. See Preedy, V. R. from rat occipital cortex tissue tion on NAD+ metabolism in leuk3 Peters, T. J. See Christensen, J. R.; chops, by Clonidine. 311 emic cells. 869 Dorey, C; Fawcett, J.; Heywood-3 O'Shaughnessy, C. T. See Fletcher, Patel, H. M. Waddington, D.; O'Connell, M. J.; E. J. ; Russell, N. J. Preedy, V. R., Simpson, K. J.; Osmundsen, H. Liposomes: from membrane model Ward, R. J. ; Hovik, R. to therapeutic applications. Intro3 ; Ward, R. J.; Duane, P.; Preedy, ^-Oxidation of polyunsaturated fatty ductory remarks. 909 V. R. acids. 420 Patel, K. J. See Evans, R. W. Clinical and experimental skeletal Othman, Y. H. S. Patel, N. J. muscle alcoholic myopathy. 250 ; Adams, D. J.; Hitchcock, C. A.; ; Llewelyn, J. G.; Thomas, P. K. Phillips, J. See Moran, E. Oakey, R. E. Sodium/potassium ATPase activity Phillips, J. D. See Wilson, A. S. Estradiol-binding protein in Candida in peripheral nervous tissue of ga3 Phillips, J. H. See Haigh, J. R. albicans. 789 lactosemic and diabetic rats. 306 Phillips, M. E. A. See France, T. D. Overath, P. See Czichos, J. ; Llewelyn, J. G.; Wright, D. W.; Pilkington, G. See Woods, M. D. Owen, J. S. See Desai, K.; Lima, V. Thomas, P. K. Pillay, T. S. See Tavare, J. M. L. M. Lack of correlation between enzymic Piper, P. J. Owens, D. See Devery, R.; O'Meara, sodium-potassium ATPase activity ; Stanton, A. W. B.; Yaacob, H. B.; N. and rubidium-81 ion uptake in Antoniw, J. ; Collins, P.; Johnson, A.; Tomkin, peripheral nerve tissue of diabetic Leukotrienes in the cardiovascular G. rats. 878 system. 482 Regulation of mitogen-induced lym• Patel, Y. See Krishnamurthi, S. Pockley, A. G. phocyte transformation by low Patestos, N. P. ; Bolton, A. E. density lipoprotein. 202 ; Radola, B. J. Effect of decidual placental protein Owusu, S. Native protein blotting after isoelec3 14 on interleukin-2-lymphocyte ; Wood, E. J. trie focusing in fabric-reinforced interactions. 794 Ornithine decarboxylase levels in Polyacrylamide gels. 154 Pollard, J. W. See Jahan, M. normal and psoriatic skin. 329 Patrick, A. D. See Hall, N. A. Pollock, H. T. See Faulkner, A. Paul, F. E. See Hughes, W. M. Poole, R. C. Pauplin, Y. ; Halestrap, A. P. Packard, C. J. See Shallal, A. ; Hombrados, I.; Faure, F.; Han, K. Purification of a 55 kDa mitochondri3 Page, M. G. P. K.; Neuzil, E. al protein by a-cyanocinnamate NAD(P)H-cytochrome reductase The primary structure of the ß-chain affinity chromatography. 602 from Escherichia coli. 872 of the hemoglobins of the ferret Portenier, M. See Box, R. J. Page, P. C. B. See Agathocleous, D. (Mustela putorius furo). 608 Porter, C D. C. Paver, J. L. ; Blake, N. W.; Archard, L. C. Pall, H. S. See Bhatti, A. R. ; Freedman, R. B.; Hortsch, M.; Structure and activity of epidermal Pallanza, G. See Casella, L. Meyer, D. growth factor-like peptides: indue3 Palmer, A. M. Specific release of protein disulfide-3 tion of basal cell proliferation by a ; Lowe, S. L.; Francis, P. T.; Bowen, isomerase from pancreatic microso3 poxvirus gene product? 671 D. M. mal membranes. 58 Potter, B. V. L. See Cooke, A. M.; Are post-mortem biochemical studies ; Freedman, R. B.; Parkhouse, R. Taylor, C. W. of human brain worthwhile?. 472 M. E. Powell, G. M. See Richards, S. Palmer, A. V. See Stefani, L. A. J. Induction of protein disulfide-isomer3 Power, C. See Mcllgorm, E. A. Palmer, R. M. J. See Moncada, S. ase during lymphocyte activation ; O'Connor, C. M.; Fitzgerald, M. Palmer, S. and maturation. 56 X. ; Hughes, K. T.; Lee, D. Y.; Wak- Characteristics of human alveolar macrophage collagenase. 391 1116 AUTHOR INDEX

Power, R. F. Rahman, M. A. Richards, S. ; Headon, D. R. ; Qureshi, H. ; Scott, I. R.; Harding, C. R.; Pow3 The molecular cloning and expression Nonenzymically glycated proteins in ell, G. M.; Curtis, C. G. of the human gene for heat shock human blood and lenticular tissue. Filaggrin: a novel component of the protein 108. 174 648 cornified envelope of the newborn Preece, J. A. Rajam, S. R. See Hey wood, B. R. rat. 324 ; Cook, E. E.; Cox, D. J.; Palmer, Rammohan, K. See Farooqui, A. A. Richardson, D. J. See McEwan, A. G. T. N. Ramsden, D. B. See Bhatti, A. R. Ridley, S. M. See Walker, K. A. Increased muscle glycogen-glucose-3 Rapoza, A. See Toth, C. A. Rigby, S. E. J. See Burch, A. M. 1-phosphate cycling in acute uremia Rashatwar, S. S. See Lincoln, T. M. Rigg, H. in the rat. 578 Ratcliffe, P. J. See Endre, Z. H. ; Knox, P. Preedy, V. R. See Peters, T. J. Ratledge, C. Low density lipoprotein inhibits the ; Edwards, P. A.; Gibbs, P. J.; Pe3 Yeasts for lipid production. 1088 cell adhesion stimulating properties ters, T. Rattray, M. of human serum. 560 Response of cardiac muscle protein ; De Belleroche, J. Rigney, E. M. synthesis to chronic ethanol expo• Evidence for time dependence of ; Mantle, T. J. sure. 783 morphine effects on cholecystokinin Chloride abolishes flux through the ; Garlick, P. J. release from rat periaqueductal 'substrate inhibition' pathway of Effects of parenterally administered grey. 538 biliverdin reductase. 403 glucose and amino acid solutions Raxworthy, M. J. See Depledge, M.; Rivett, A. J. for 6 h on cardiac muscle protein Rowling, P. J. E.; Wood, E. J. A complex high molecular mass non-3 synthesis in fasted rats. 782 ; Holland, D. B.; Cunliffe, W. J.; lysosomal proteinase of mammalian ; Peters, T. J. Wood, E. J. cells. 629 Effect of chronic ethanol ingestion Vitamin A and calcium ions have Robb, D. A. See Olufemi, O. S. on protein turnover in soleus and distinct effects on keratin expression Roberts, G. A. plantaris muscles of the rat. 571 in epithelial cells. 327 ; Tombs, M. P. ; Venkatesan, S.; Peters, T. J.; Nott, Redwood, C. See Marston, S. Surface properties of Chromobacter D. M.; Yates, J.; Jenkins, S. A. Reed, B. Y. viscosum lipase at a heptane-water Effect of chronic ethanol administra3 ; King, M. T.; Gerhart, M. J.; interface. 273 tion on musculoskeletal blood flow Veech, R. L. Roberts, G. C. K. in the rat. 576 Effects of angiotensin in the liver of Molecular recognition by dihydrofo3 Prescott, A. See Mangnall, D. the rat in vivo. 636 late reductase: NMR studies of Prescott, A. R. See Woodley, J. F. Reed, L. J. protein-ligand interactions. 925 Prescott, C. D. ; De Belleroche, J. Roberts, G. M. See Zhang, L. ; Green, S. R.; Tuite, M. F. Elevated polyphosphoinositide re• Roberts, J. A. Molecular analysis of the eukaryotic sponsiveness and increased ornithine ; Husain, O. A. N.; Chayen, J.; initiation factor eIF-2 from yeast. decarboxylase activity in the cere• Bitensky, L. 45 bral cortex induced by cholinergic The need for examining enzymic Prescott, M. See Agathocleous, D. C; denervation. 467 activity in intact cells to discrimi3 Taylor, G. E. Reed, P. J. See Tarn, R. C. nate bladder malignancy. 555 Price, C. Reen, D. J. See Doran, M. Roberts, P. J. See Kuonen, D. R.; ; Bickle, T. A. Assessment of immunoblotting in the Neville, L. F.; Sharpe, J. A. Evolution of DNA sequence specifici• investigation of specific immune Robins, R. J. ty in type I restriction enzymes. responses during infection. 132 ; Parr, A. J.; Rhodes, M. J. C. 942 Reeves, M. L. See Murray, K. J. The use of continuous product re3 Price, R. J. See Skilleter, D. N. Reid, A. D. See Baker, P. R. moval to influence the distribution Pries tie, J. P. Reid, G. A. and net production of alkaloids by ; Schaer, H. P.; Gruetter, M. G. ; Walker, M. E. cell cultures. 67 The three-dimensional structure of Mitochondrial protein targeting sig= Robins, S. P. See Black, D. interleukin-lß. 949 nals. 709 Robinson, C. See Ellis, R. J. Princen, H. See Kempen, H. J. Reid, I. W. See Pennington, J. Robinson, D. Pringle, J. A. S. See Hayman, A. R. Reid, K. B. M. See Malhotra, R. Shedding light on lysosomes - appli3 Pritchard, K. See Marston, S. Reid, L. See Freedman, R. B. cations of fluorescence techniques ; Marston, S. B. Reid, N. See Ward, R. J. to cell biology and diagnosis of The control of calcium-regulated Reidlinger, J. A. See Tuzi, N. L. lysosomal disorders. 11 thin filaments from vascular smooth Renaudin, J. P. Rodger, I. W. See Langlands, J. M. muscle by calmodulin and other ; Guern, J. Rodrigues, L. M. See Stubbs, M. calcium-binding proteins. 355 Compartmentation of ajmalicine in Roesler, W. J. See Sohal, P. S. Puente, J. See Lavandero, S. the vacuoles from Catharanthus Rogers, L. J. See Davies, T. G. E.; Punchard, N. A. See Berry, R. M. roseus. 63 Nock, L. P. Pusztai, A. See Grant, G.; Santoro, L. Rennie, P. J. Rolfe, P. See Thorniley, M. S. G. ; Holland, K. T.; Mallet, A. I.; Wat3 Rombauts, W. A. J. A. kins, W. J.; Gower, D. B. A European perspective on postgrad3 Use of capillary gas chromatogra3 uate education. 122 Quant, P. A. phy-mass spectrometry in the eluci3 Romero, F. J. See Almar, M. M. ; Tubbs, P. K.; Brand, M. D. elation of odorous 16-androstene Roncero, C. See Lorenzo, M. Mannoheptulose and glucagon treat• metabolism in human axillary bacte3 Rooney, E. K. See Michelangeli, F. ment of fed rats stimulates 3-hy- ria. 738 Rosseil, R. J. droxy-3-methylglutaryl-CoA syn• Renz, M. See Hitzeman, R. A. ; Stevens, A. F.; Miles, M. A.; Aller, thase activity in rat liver mito• Rey, H. G. See Anner, B. M. A. K. chondria by desuccinylation of the Reynolds, R. See Carey, E. M. Interaction of lectins with the parasi3 enzyme. 633 Rhodes, M. J. C. See Robins, R. J. tic protozoans Trypanosoma cruzi Qureshi, H. See Rahman, M. A. Rice-Evans, C. See Horton, R. A.; and Leishmania. 586 Jones, S. A. Rossi, A. G. Rich, K. J. ; Maclntyre, D. E.; McMillan, R. Radda, G. K. See Allis, J. L.; Endre, ; Boobis, A. R.; Foster, J. R.; Ses3 M. Z. H. ardic, D.; Davies, D. S. Human neutrophil activation: cyto3 Rademacher, T. W. See Ferguson, M. Immunohistochemical localization of solic free calcium - thresholds for A. J. cytochrome P-450 b/e in hepatic aggregation, degranulation, leukotri= Radola, B. J. See Patestos, N. P. and extrahepatic rat tissues. 642 ene B4 synthesis and phosphatidate Rahman, K. Richards, R. J. See Lewis, R. W. formation. 37 ; Voss, U.; Nicholls, P. J.; Malcolm, Richards, R. L. Rowatt, E. A. D. B. ; Havre, M. D.; Hockmeyer, W. T.; ; Williams, R. J. P. Nucleic acid purification by fast Alving, C. R. Specificity of cation binding by a dye protein liquid chromatography. Liposomes as carriers for a human and a lipopolysaccharide. 716 368 malaria sporozoite vaccine. 921 AUTHOR INDEX 1117

Rowling, P. J. E. See Depledge, M. Saito, N. See Shearman, M. S. Segura, J. See Murray, B. P. ; Raxworthy, M. J.; Kearney, J. N. Salih, S. G. Sekiguchi, K. See Shearman, M. S. Collagenase activity during the re• ; Khan, J. A.; Newton, R. P. Sellers, L. A. See Mall, A. S. modeling of a dermal equivalent. Cytidine 3',5'-cyclic monophosphate Sesardic, D. See Rich, K. J. 326 phosphodiesterase: immunoreactivi3 Seto-Oshima, A. Rowney, D. A. See Hodgins, M. B. ty and differential sensitivity to ; Emson, P. C; Berchtold, M. W.; Rugg, E. L. endogenous effectors. 774 Heizmann, C. W. ; Cramb, G.; Aiton, J. F. Salim, M. L. Localization of sites of parvalbumin Characterization of atrial natriuretic ; El Jamil, A. S.; Harrington, M. G. gene expression. 313 peptide receptors in rat cardiac Effects of dietary supplementation Sever, P. S. See Dunn, R. C; Miles, sarcolemma. 1022 with pyridoxal 5'-phosphate and C. M. M. Ruiz de Elvira, M. C. polyunsaturated fatty acids on rat Seymour, M. A. ; Sinha, A. K.; Ekins, R. P. platelet aggregation. 385 ; Millburn, P.; Tail, G. H. Development of an enzyme assay for Sanghera, G. S. See Barker, P. D. Comparative enzymology of hippu3 the measurement of calmodulin-de3 Santoro, L. G. rate, ornithurate and benzoyl glucu3 pendent phosphatase in brain tis3 ; Grant, G.; Pusztai, A. ronide synthesis. 1021 sue. 297 Differences in the degradation in Shallal, A. Rumsby, M. G. See Murphy, J. A. vivo and in vitro of phaseolin, the ; Al-Mahdawi, S.; Converse, C. A.; Ruparelia, B. See Watson, D. major storage protein of Phaseolus Packard, C. J.; Shepherd, J. Rushmere, N. K. See Davies, P. vulgaris seeds. 612 Cross-reactivity between anti-apoli3 Russell, M. G. N. See Davis, P. D. Sapag-Hagar, M. See Lavandero, S. poprotein E antisera and retinal Russell, N. J. See Patel, H. M. Saperstein, R. See Vicario, P. P. inter photoreceptor retinoid-binding Russell, R. G. G. See Kemp, G. J. Sardiwal, S. See Brammer, M. protein. 318 Rutherford, D. M. Sarra, R. See Lindley, P. F. Shamsadeen, N. ; Jeffery, D.; Lunt, G. G.; Weitz3 Sattelle, D. B. See Lummis, S. C. R. ; Duncan, C. J. man, P. D. J. Saunders, D. See Fallowfield, C. Action of lysosomotropic agents on Benzodiazepine receptors in locust Savva, D. See Perry, B. N. mammalian skeletal muscle. 786 (Schistocerca gregaria) ganglia: Sawecka, J. See Blair, G. E. Is there an oxygen paradox in skeletal binding of Rol5-1788. 310 Scaife, C. muscle? 1050 Rutter, G. A. ; Masterson, B. F. Shand, J. H. ; Denton, R. M. Proton dissociations of metal com3 ; West, D. W. Rapid purification and properties of plexes of naturally occurring carbox3 Cholesterol ester synthesis in the rat pig heart NAD+-isocitrate dehydro• ylic acids. 406 mammary gland. 1013 genase. 873 Scarlett, L. See Forster, S. Sharif, M. A. Ryan, A. J. Sea wen, M. See Perry, N.; Spencer, ; Whish, W. J. D.; White, C. J. B.; ; Blanchard, A. D.; O'Connor, P. J.; P. Brunt, R. V. Billett, M. A. Schachter, M. See Dunn, R. C; Miles, Identification of an adenosine-de3 Micrococcal nuclease digests intranu- C. M. M. pendent trifluoperazine (Stelazine)-3 cleosomal DNA of inactive genes Schaer, H. P. See Priestie, J. P. sensitive system in the tegumental more rapidly than active genes. Schärpe, S. See Hendriks, D. membrane of the rat tapeworm 1060 Scherly, D. See Hamm, J. Hymenolepis diminuta. 868 ; O'Connor, P. J.; Billett, M. A. Schiffmann, Y. Sharma, R. J. Increased oncogene expression in Hormone action as an explosive reac3 ; Grant, D. A. W. livers of rats after exposure to dime3 tion. 562 Does ethanol have a biphasic effect thylnitrosamine. 1058 Bifurcation in phosphorylation. 645 on iron uptake from transferrin by Ryan, J. P. Schlenstedt, G. See Mueller, G. isolated hepatocytes? 575 ; Davis, G. Schmidt, H. The uptake of iron by hepatocytes is Inhibition of prostaglandin synthase ; Wegener, G. not coincident with transferrin by some low molecular mass fatty Glycogen Phosphorylase in fish brain endocytosis. 618 acids. 398 (Carassius carassius) during hypo3 Sharpe, J. A. Ryan, M. P. See Godson, C. xia. 621 ; Roberts, P. J. Ryan, N. M. See Ohlendieck, K. Schräder, W. T. See Conneely, O. M. Solubilization of L-[3H]-glutamate Rye, P. D. Schulster, D. See Moreland, B. H. binding sites sensitive to N-methy3 ; Walker, R. A. Schultz-Borchard, U. See Kunau, laspartate and quisqualate. 314 Altered expression in vitro of human W. H. Shaw, W. V. See Day, P. J.; Thomas, breast tumor associated glycopro• Schulz, G. E. C. D. teins by hormone additives. 1026 ; Karplus, P. A. ; Day, P.; Lewendon, A.; Murray, I. High resolution structure and catalyt3 A. ic action of human glutathione Tinkering with antibiotic resistance: Sadler, P. J. See Bell, J. D. reductase. 81 chloramphenicol acetyltransferase Saeed, S. A. Schurmans, S. See Stott, D. I. and its substrates. 939 Purification of human lactate dehy• Schuster, W. See Martin, F. Shearman, M. S. drogenase isoenzymes by preparative Schwarz, R. T. See Menon, A. K. ; Ase, K.; Saito, N.; Sekiguchi, K.; gel electrophoresis, gel chromatogra3 Scobie, G. See Llewellyn, D. H. Ogita, K.; Kikkawa, U.; Tanaka, C; phy and ion-exchange chromatogra3 Scott, A. K. See Pennington, J. Nishizuka, Y. phy. 18 Scott, D. L. See French, R. C. Molecular heterogeneity and differen3 Tissue-specific regulation of platelet Scott, I. R. See Richards, S. tial expression of multiple protein aggregation: inhibition of rat liver Scott, J. E. kinase C subspecies in central nerv3 cytosol. 898 ; Haigh, M.; Ali, P. ous tissue. 460 ; Gilani, A. H. Keratan sulfate is unevenly distribute ; Kosaka, Y.; Ase, K.; Kikkawa, U.; Differential effects of anticholinergic ed from back to front of bovine Nishizuka, Y. drugs on platelet aggregation in3 cornea. 333 Type I (7) protein kinase C subspe3 duced by platelet-activating factor Scragg, A. H. cies appears to be located exclusively and other agents. 815 ; Morris, P.; Bond, P.; Ashton, S.; in central nervous tissues. 307 ; Karimi, S. J.; Atta-ur-Rahman; Cresswell, R. C; Fowler, M. W. . Sheerin, N. See Moreland, B. H. Suria, A. Production of alkaloids in large-scale Sheldon, P. S. Inhibitors of human platelet aggrega3 cultures of Catharanthus roseus. ; Safford, R.; Slabas, A. R.; Kek3 tion in barley extracts. 19 65 wick, R. G. O. ; Nasreen, R.; Amirali, S.; Suria, A. Scrutton, N. S. See Per ham, R. N. 2-Oxoacyl-[acyl carrier protein] Inhibition of arachidonate lipoxyge3 Seaton, P. See Hunt, A. reductase: a component of plant nase by ketotifen. 814 ; Hunt, A.; Patel, A. J. fatty acid synthase. 392 Safford, R. See Sheldon, P. S. Production by astrocytes of a tropic Shelton, J. B. Sagar, K. A. factor for cholinergic neurons. 296 ; Chegwidden, W. R. ; Masterson, B. F. Seddon, C. E. See Nasseri-Sina, P. Activation of carbonic anhydrase III Stability of the heme of oxyhemoglo3 by phosphate. 853 bin denatured by alkali. 386 1118 AUTHOR INDEX

Shepherd, I. M. See Turnbull, D. M. Plant host-pathogen interaction: vesicles prepared with sterol ex= Shepherd, J. See Shallal, A. elicitation of phenylalanine ammonia tracts from fenpropimorph-grown Sheridan, M. lyase activity and its mediation by fungi. 350 ; Wilton, D. calcium. 1069 Steele, G. See Toth, C. A. Dansylaminodecyl agarose - a novel Smith, D. E. See Fisher, P. A. Stefani, L. A. J. affinity column for rat liver fatty Smith, G. D. See Christensen, J. R.; ; Palmer, A. V.; Galt, J.; Ferguson-- acid binding protein. 719 Fawcett, J. Smith, M. A.; Nevin, N. C. Sherratt, H. S. A. Smith, J. M. A. The expression of sequences which The enzymology of ß-oxidation. 409 ; Ford, G. C; Harrison, P. M. map to chromosome 21 in normal Sheth, B. See Dransfield, I. Very-low-resolution structure of a and Down's syndrome tissues. 171 Shibuya, A. See Yoshida, A. bacterioferritin. 836 Stegeman, J. J. See Livingstone, D. Shields, D. Smith, K. R. See Booth, A. G. R. ; McConnell, D. J.; Winder, F. G. Smith, L. D. Steven, F. S. Cloning of part of the gene for bovine ; Bungard, S. J.; Danson, M. J.; ; Griffin, M. M.; Maier, H. deoxyribonuclease I. 195 Hough, D. W. Inhibition of a tumor-associated Shone, C. C. See Wadsworth, J. D. F. Archaebacterial dehydrogenases with protease. 556 Shori, D. K. dual cofactor specificity: glucose Stevens, A. F. See Rosseil, R. J. ; Bradbury, N. A.; Goodchild, M. dehydrogenase from Thermoplasma Stewart, G. S. A. B. See Ahmad, K. G.; Dormer, R. L.; McPherson, M. acidophilum. 864 A.; Iwanejko, L. A. A. Smith, M. See Davies, A. M. Stewart, J. C. See Grant, G. Altered calmodulin function in cystic Molecular genetic studies on alcohol Stirling, J. M. fibrosis. 345 and aldehyde dehydrogenase: indi= ; Cross, A. J.; Green, A. R. Short, K. C. vidual variation, gene mapping and [3H]l-[l-(2-Thienyl)-cyclohexyl]pi- A public sector viewpoint of research analysis of regulation. 227 peridine binding to the N-methyl-- 128 Smith, P. E. See Bunn, D. N. D-aspartic acid receptor complex. Siddall, R. M. Smith, R. See King, G. F. 300 Career opportunity for postgraduate Smith, T. A. Stirling, Y. See Cook, M. students. 128 ; Marshall, J. H. A. Stoecker, G. Siddle, K. See Tavare, J. M. Oxidative decarboxylation of amino ; Greiling, H.; Wagener, C. Sim, R. B. See Malhotra, R. acids by plant extracts. 972 Rapid identification of biotinylated Simon, J. M. Smith, T. P. See Lockhart, B. P. proteoglycans from human aorta by ; Duffy, M. J. Smithers, S. R. See Simpson, A. J. G. enzymic digestion and Western Distribution, characterization and Smyth, D. G. See Cockle, S. M. blots. 159 clinical significance of a cathepsin Smyth, H. See McGuinness, M. Stott, D. I. B-like enzyme in breast cancer. Smyth, P. P. A. See Corcoran, A. E. ; Hassman, R.; Neilson, L.; McGre= 192 Snell, K. gor, A. M. Simpson, A. J. G. ; Barnett, C. R. Isoelectric focusing spectrotypes of ; Ali, P. O.; Yi, X.; Smithers, S. R. Serine metabolism in lectin-activated anti-thyroglobulin autoantibodies Schistosome glycoconjugates as anti= human lymphocytes. 622 in autoimmune thyroiditis: an gens and their relevance in experi3 Sohal, P. S. AUG rat model. 728 mental and human schistosomiasis. ; Roesler, W. J.; Khandelwal, R. L.; Isoelectric focusing spectrotypes of 264 Angel, J. F. anti-thyroglobulin autoantibodies Simpson, K. J. Age-related changes in hepatic malic in autoimmune thyroiditis: a PVG ; Venkatesan, S.; Peters, T. J. enzyme activity and plasma thyroid rat model. 729 Effect of acute alcohol dosage on hormone levels in the genetically ; Merino, J.; Schurmans, S.; Lam• hepatic acetyl-CoA carboxylase and diabetic (db/db) mouse. 31 bert, P. H. fatty acid synthase activities. 580 Hormonal regulation of malic enzyme Analysis of the autoimmune response Simpson, R. J. See Dorey, C. and glucose-6-phosphate dehydro• to DNA in tolerant mice by isoelec• Singh, A. See Hitzeman, R. A. genase in adult rat liver. 33 tric focusing and reverse immunob3 Singh, J. See Thornton, J. M. Soler, G. See Bautista, J. M. lotting. 1: Clonal restriction and Singh, S. See Barlow, D. J. Spencer, I. M. See Hughes, G. M. time course. 147 Sinha, A. K. See Ruiz de Elvira, M. ; Hargreaves, I.; Chegwidden, W. R. Analysis of the autoimmune response C. Effect of the carbonic anhydrase to DNA in tolerant mice by isoelec• Sinnett-Smith, P. A. See Harrison, inhibitor acetazolamide on lipid tric focusing and reverse immunob- L. M. synthesis in the locust. 973 lotting. 2: The role of helper T-cells Sjoeberg, B. M. See Nilsson, O. Spencer, P. See Perry, N. and major histocompatibility com• Skacel, P. O. ; Bown, K.; Scawen, M.; Atkinson, plex antigens. 148 ; Watkins, W. M. T.; Gore, M. Strain, J. J. See Eason, S. a-3-Fucosyltransferase expression in Interaction between the apo-glycerol Strange, P. G. See Williamson, R. A. leukemia. 1034 dehydrogenase from Bacillus stear- Street, G. Skidmore, C. J. See Faruque, S. M.; othermophilus and zinc ions. 975 The impingement of biochemistry on Ferrie, R. M.; Patel, B. N.; Perry, Spencer, S. chemical engineering. 516 B. N. ; Burnet, F. Strike, A. J. See Khodr, H. Skilleter, D. N. Developmental changes in avian Strupish, J. See Cooke, A. M. ; Price, R. J. hepatic testosterone metabolism. Stuart, R. A. Effects of beryllium ions on tyrosine 22 ; Nicholson, D. W.; Harmey, M. A.; phosphorylation. 1047 Spiegel, A. M. See McKenzie, F. R. Neupert, W. Slabas, A. R. See Sheldon, P. S. Spiro, S. Biogenesis of mitochondrial proteins. Slaughter, R. S. See Kaczorowski, G. ; Todd, M. H.; Artymiuk, P. J.; 701 J. Guest, J. R. Stubberfield, C. R. Slayter, H. S. See Hutton, D. A. A proposal for the DNA-binding ; Forrow, S. M. A.; Zaera, E.; Co• Slow, Y. See Baker, P. R. specificity of the FNR protein of hen, G. M. Small, C. A. Escherichia coli. 755 Redox cycling quinones induce an ; Garton, A. J.; Yeaman, S. J. Sprandel, U. interconversion of hepatocyte pyri• Evidence for the presence of hor= ; Zoellner, N. dine nucleotides. 866 mone-sensitive lipase in heart mus= Biochemical studies of glucosidase Stubbs, M. cle. 1038 encapsulated in erythrocytes. 1051 ; Vanstapel, F.; Rodrigues, L. M.; Small, G. M. See Lazarow, P. B. Stace, B. C. See Dorr, A. W. Griffiths, J. R. Smallwood, A. E. See Makoff, A. J. Staehelin, M. See Box, R. J. Phosphate metabolites in rat skin. Smeaton, L. A. See Lynn, A. G. Stanton, A. W. B. See Piper, P. J. 324 Smith, B. W. See King, D. J. Stapleton, A. See Brown, M. C. S. Stutchfield, J. Smith, C. A. See James, H. M. Stebbing, A. See Winterbourne, D. J. ; Cockcroft, S. Smith, C. J. Steel, C. C. See Long, M. T. Effects of phorbol ester on inositol ; Newton, R. P.; Mullins, C. J.; ; Mercer, E. I. trisphosphate production and se~ Walton, T. J. Glucose permeability of liposome cretion in permeabilized HL 60 cells. 994 AUTHOR INDEX 1119

Sudbery, P. E. Taggart, M. J. ; Hughes, M. S.; Partridge, S.; Olu- ; Gleeson, M. A.; Veale, R. A.; Lede- ; Marston, S. B. funwa, R. I.; Marr, G.; Birch, N. J. boer, A. M.; Zoetmulder, M. C. M. Caldesmon can relax 'desensitized' Nuclear magnetic resonance studies Hansenula polymorpha as a novel skeletal muscle fibers. 360 of lithium ion transport in isolated yeast system for the expression of Tait, G. H. See Seymour, M. A. rat hepatocytes. 208 heterologous genes. 1081 Tait, S. See Martin, F. Thomas, H. See Davies, T. G. E.; Suer, A. H. See Wali, F. A. Takahashi, N. See Jefferis, R. Nock, L. P. Sugden, M. C. See Cox, D. J.; Holness, Talwar, D. See Olufemi, O. S. Thomas, J. H. M. J.; Jin, D. Y. Tarn, R. C. The 'R. H. A. Plimmer Collection' at ; French, T. J.; Holness, M. J. ; Bedwell, J.; Reed, P. J.; Cotes, P. St. Thomas's Hospital. 601 Insulin affects hepatic carnitine me= M. Thomas, P. See Toth, C. A. tabolism after the administration of Anomalous radioimmunoassay esti— Thomas, P. K. See Patel, N. J. glucose to 48-h-starved rats. 1014 mates of submaxillary gland eryth= Thomas, S. See Winterbourne, D. J. ; Holness, M. J.; Jin, D. Y.; Ma= ropoietin. 564 Thompson, G. G. See Herrick, A. L.; cLennan, P. A.; Goode, A. W. Tanaka, C. See Shearman, M. S. Houston, T. Cardiac pyruvate dehydrogenase Tanner, V. Thompson, M. G. complex activity after aortic con= ; Knox, P. ; Hickman, J. A. striction. 772 Fibronectin does not enhance the Elevation of HL-60 cell intracellular ; Maclennan, P. A.; Holness, M. J. endocytosis of fibrin breakdown calcium by the cytotoxic ether lipid Effects of substrate supply on hepatic peptides. 559 SRI 62-834 and antagonism by fructose 2,6-bisphosphate concen- Tarbit, M. H. See Disney, G. 12-O-tetradecanoylphorbol 13-ace- trations in vivo. 1015 Tashian, R. E. See Chegwidden, W. tate. 278 Sugrue, R. R. Thompson, M. H. See Wait, R. ; Freedman, R. B.; Lowe, P. A.; Tavare J Thompson, R. J. See Bassett, J. H. Marston, F. A. O. ; O'Brien, R. M.; Pillay, T. S.; Dick- D.; Day, I. N. M. Reversible and irreversible denatura= ens, M.; Siddle, K.; Denton, R. M. Thompson, R. P. H. See Berry, R. M. tion: rationale for a process for Analysis of the sites of phosphoryla- Thomson, A. J. See Armstrong, F. A. recovery of recombinant prochymo- tion of the insulin receptor in vitro Thorne, B. sin. 59 and in vivo. 1065 ; Irons, J.; Lunt, G. G.; Wonnacott, Suleiman, M. S. Tax, W. J. M. See Van de Winkel, J. S.; Dunkley, P. R. Towards understanding the role of G. J. Comparison of methods for rapid the sodium-calcium exchanger in Taylor, C. W. isolation of synaptosomes from cardiovascular activities: utilization ; Berridge, M. J.; Cooke, A. M.; brain regions, for uptake and release of harmaline. 539 Potter, B. V. L. studies. 309 Effect of variation in external sodium A stable analog of inositol trisphosp3 Thorneley, R. N. F. See Barker, P. D. concentration on ileal smooth mus- hate which mobilizes intracellular Thorniley, M. S. cle of the rabbit, guinea pig and the calcium. 995 ; Wickramasinghe, Y. A. B. D.; rat. 588 Taylor, D. J. Rolfe, P. Sodium-calcium exchanger and the ; Evanson, J. M.; Woolley, D. E. Near infra-red spectroscopy: a new origin of spontaneous contractions Comparison of the mechanistic effects technique for the non-invasive in intestinal smooth muscle: utiliza= of cytokines and a phorbol ester on monitoring of tissue and blood tion of harmaline. 589 synovial cell and chondrocyte glycol oxygenation in vivo. 978 Suria, A. See Saeed, S. A. lysis. 889 Near infra-red spectroscopy: moni• Sutherland, I. A. See Hey wood-Wad= Taylor, D. S. toring cerebral tissue oxygenation dington, D. ; Green, A. K.; Fisher, M. J. non-destructively in the rat and Sutherland, J. L. Impact of experimental diabetes on rabbit brain. 980 ; Coleman, G. phenylalanine hydroxylase express Thornton, J. M. A comparison of exotoxin patterns of sion in rat liver. 1057 ; Singh, J.; Campbell, S.; Blundell, Staphylococcus aureus strains isolat= Taylor, G. E. T. L. ed from osteomyelitic lesions with ; Blackburn, G. M.; Prescott, M.; Protein-protein recognition via side-- those from topical infections. 1000 McLennan, A. G. chain interactions. 927 Sutton, C. M. Phosphonate analogs of bis(5'-adeno- Threlfall, D. R. ; Botham, K. M. syl)tetraphosphate. 713 ; Whitehead, I. M. Comparison of the effect of dietary Taylor, G. W. See Watson, D. The use of biotic and abiotic elicitors cholesterol on bile acid synthesis in Taylor, J. to induce the formation of secondary isolated hepatocytes in suspension ; Gordon-Weeks, P. R. plant products in cell suspension and in culture. 1001 An investigation into the develop3 cultures of solanaceous plants. 71 Swann, I. D. ment of calcium-dependent neuro• Thurgood, A. G. P. See Davies, A. M. ; Ashford, A.; Bailey, G. S. transmitter release from isolated Tippins, J. R. See Garlick, P. B. An investigation of the kallikrein-ki- growth cones. 444 Tipton, K. F. See Harrington, M. C. nin system in normal and ischemic Taylor, P. W. See Hughes, W. M. Tirapegui, J. O. See Yahya, Z. A. H. rat hearts. 1011 Tebb, G. See Howard, T. D. Titheradge, M. A. See Jones, C. G. Swanson, T. Tezapsidis, N. Todd, M. H. See Spiro, S. ; Kalsheker, N.; Neale, M. L.; Mat- ; Eaton, S. J.; Parish, D. C. Tombs, M. P. See Roberts, G. A. thews, N. Purification of secretory vesicles Tomkin, G. See Devery, R.; Owens, D. ai-Antitrypsin messenger RNA pro= from ovine adrenal medulla and Tomkin, G. H. See O'Meara, N. duction is stimulated by tumor neurointermediate pituitary. 51 Tomlinson, S. See Best, L.; Bone, E. necrosis factor and an additional Thieret, R. L. See Zhang, H. A.; Tuersley, M. D. transcript is produced. 1055 Thieringer, R. See Kunau, W. H. Tones, M. A. Sweetman, A. J. See James, H. M. Thoegersen, H. C. See Nagai, K. ; Bootman, M. D.; Pay, G. F. Symington, P. R. Thomas, C. D. Effect of inositol tetrakisphosphates ; Ashford, A.; Bailey, G. S. ; Balson, D. F.; Shaw, W. V. on inositol 1,4,5-trisphosphate bind• Effect of bradykinin and insulin on Identification of the tyrosine residue ing to rat liver microsomes. 593 glucose oxidation in adipocytes involved in bond formation between Torrance, M. R. See Hodgson, J. A. from normal and streptozotocin replication origin and initiator pro• Tosh, D. diabetic rats. 1012 tein of plasmid pC221. 758 ; Agius, L. Szabo, E. F. P. ; Shaw, W. V.; Lawson, D. M.; Tref- Heterogeneity of fatty acid metabolism Dimethylaminoethyl acetate - the fry, A.; Artymiuk, P. J.; Harrison. and glucagon action in hepatocytes hormone of the adrenal gland with P. M. from different acinar zones of rat parasympathetic effects and the Expression and purification of the liver. 1007 neurovegetative transmitter. 565 rat liver ferritin light chain after Toth, C. A. cloning in Escherichia coli. 838 ; Kowal, A.; Thomas, P. Thomas, G. M. H. See Hughes, M. S.; Interferon-induced modulation of Taggart, M. See Marston, S. Partridge, S. cellular growth and antigen expres• sion by human colon tumor cells. 1049 1120 AUTHOR INDEX

; Rapoza, A.; Kowal, A.; Steele, G.; Vanden Abeele, C. O. Thomas, P. ; Vandenheede, J. R.; Merlevede, Roles of the constituent chains of Receptor-mediated endocytosis by W. botulinum neurotoxin type A in the human Kupffer ceils. 1027 Polyclonal antibodies to the modula= blockade of neuromuscular trans• Towbin, H. tor protein of the ATP,magnesium-= mission in mice. 886 Immunoblotting - an update. 131 dependent protein phosphatase. Wagener, C. See Stoecker, G. Tracey, B. M. 720 Wahle, K. W. J. See Macdonald, A. ; Cheng, K. N.; Chalmers, R. A. Vandenheede, J. R. See Vanden G.; Peacock, L. I. L. Mass spectrometric identification of Abeele, C. Wait, R. dicarboxylic acid glucuronide esters Vanderkerckhove, J. ; Leach, S. A.; Hill, M. J.; Thomp= in patients with dicarboxylic acidu= Amino acid analysis and sequencing son, M. H. ria. 744 of blotted proteins. 140 Fast atom bombardment mass spec= Trautmann, A. Van der Vies, S. M. See Ellis, R.J. trometry of some N-nitroso pep= Functions of gap junction channels Van de Winkel, J. G. J. tides. 740 in the open and closed states. 534 ; Van Duijnhoven, H. L. P.; Van Wajner, M. Tray burn, P. See Milner, R. E. Ommen, R.; Tax, W. J. M. ; Harkness, R. A. Treacy, M. See Martin, F. Characteristics and inter-relation of Distribution of xanthine dehydroge= Treffry, A. See Andrews, S. C; 0*Con= two types of immunoglobulin G Fc nase and oxidase activities in human nell, M. J.; Thomas, C. D. receptors on human monocytes. and rabbit tissues. 358 Trombetta, S. See Bosch, M. 734 Wakelam, M. J. O. See Black, F. M.; Tsai, M. J. See Conneely, O. M. Van Duijnhoven, H. L. P. See Van Palmer, S. Tubbs, P. K. See Quant, P. A. de Winkel, J. G. J. Wakeling, A. E. See Wiseman, L. R. Tuersley, M. D. Van Hoof, F. Wali, F. A. See Makinde, V. ; Best, L.; Tomlinson, S. ; Vamecq, J.; Draye, J. P.; Veitch, Comparative neuromuscular blocking Inositol uptake and metabolism in K. effects due to prolonged intermit= molluskan neuronal tissue. 316 The catabolism of medium- and tent nerve stimulation and to d-tu= Tuite, M. F. See Prescott, C. D. long-chain dicarboxylic acids. 423 bocurarine in the rat diaphragm ; Izgu, F.; Grant, CM.; Crouzet, Vanhoof, G. See Hendriks, D. preparation. 747 M. Van Ommen, R. See Van de Winkel, ; Brain, A. I. J. Allosuppressor genes and the control J. G. J. Conduction block in frog isolated of translational fidelity in yeast. 30 Van Sande, M. See Hendriks, D. sciatic nerve-gastrocnemius muscle Tunwell, R. E. A. See Mata, A. M. Van Schie, R. See Kempen, H.J. preparation due to electromagnetic Turco, S. J. Vanstapel, F. See Stubbs, M. stimulation. 1020 Proposal for a function of the Leish^ Vaughan, P. F. T. See Ong, M. L.; ; Greenidge, E. mania donovani lipophosphoglycan. Woods, M. D. Comparative effects of phenyleph= 259 Veale, R. A. See Sudbery, P. E. rine, Clonidine and potassium chlo• Turnbull, D. M. Veech, R. L. See Gitomer, W. L.; ride on tone and contractility of rat ; Shepherd, I. M.; Aynsley-Green, Reed, B. Y. isolated seminal vesicle. 1021 A. Vehar, G. See Hitzeman, R. A. ; Hayter, A. P.; Suer, A. H. Inherited defects of mitochondrial Veitch, K. See Van Hoof, F. Interaction of ethanol with calcium fatty acid oxidation. 424 Venables, P. J. W. See Horsfall, A. C. channel blockers: nimodipine, ni^ Turner, A. J. See Hooper, N. M. Venkatesan, S. See Preedy, V. R.; trendipine, nifedipine in isolated Turner, D. M. See Holland, D. B. Simpson, K. J. vas deferens preparation of the rat. Turner, R. See Jackson, P. J. Venter, D. J. See Tuzi, N. L. 381 Turner, R. C. See Hathaway, D. R. Verkerk, R. See Hendriks, D. ; Suer, A. H. Tuzi, N. L. Veys, P. A. Use of glycopyrrolate, atropine, in ; Venter, D. J.; Reidlinger, J. A.; ; Macey, M.; Newland, A. C. mixtures with neostigmine, to re= Dean, C. J.; Gullick, W. J. Autoimmune neutropenia and the verse neuromuscular blockade pro= Production and characterization of neutrophil FcR. 732 duced by atracurium in man. 746 monoclonal antibodies to the c-= Vicario, P. P. ; Suer, A. H.; Altinel, A. erbB-2 proto-oncogene protein ; Saperstein, R.; Bennun, A. Fatigue of the adductor pollicis mus= using a synthetic peptide immuno= Regulation of insulin receptor tyro= cle and the effect of a skeletal mus= gen. 675 sine kinase by divalent metal cat• cle relaxant, atracurium. 336 ions, metal-ATP substrate and free Effects of laudanosine and atracurium ATP. 40 at the rat neuromuscular junction. Uhlen, M. Interactions of insulin receptor tyro^ 336 ; Moks, T.; Abrahmsen, L. sine kinase with heavy metals. 896 ; Suer, A. H.; Hayter, A. P.; Green= Protein engineering to optimize re= Vincent, J. B. idge, E.; Dark, C. H. combinant protein purification. ; Folting, K.; Huffman, J. C; Chris= Twitch and tetanic fatigue in the rat Ill tou, G. diaphragm preparation stimulated Umiel, T. See Hendriks, D. Dinuclear manganese-oxide complex= indirectly at 1-100 Hz. 382 Underwood, B. See Dorr, A. W. es as models for manganese cata= Walker, B. See Beattie, R. E.; Doug= Unitt, J. F. läse. 822 las, A. J.; Nunn, J. D. ; McCormack, J. G.; England, P. J. Vinson, G. P. See Watson, D. Walker, C. H. See Borlakoglu, J. T. Effects of ruthenium red on oxygen Virmaux, N. See Urban, P. F. Walker, J. H. uptake and lactate and carbon diox= Voaden, M. J. See Arden, G. B.; Hus= Inexpensive equipment for polyacry= ide production by the perfused rat sain, A. A.; Willmott, N. J. lamide-slab-gel electrophoresis and heart in the absence and presence Vogel, U. S. See Bassett, J. H. D. flat-bed electroblotting. 762 of isoprenaline. 591 Von Bahr-Lindstroem, H. See Joern= Walker, K. A. Unson, C. G. See McKenzie, F. R. vail, H. ; Ridley, S. M.; Har.wood, J. L. Urban, J. P. G. See Hall, A. C. Von Stockar, U. See Marison, I. W. Inhibition of fatty acid synthesis in Urban, P. F. Voss, U. See Rahman, K. plants by a selective herbicide, ; Ancel, R.; Virmaux, N. Voss, U. B. fluazifop. 277 A soluble protein in rod outer seg= ; Malcolm, A. D. B. Walker, M. E. See Reid, G. A. ments stained blue by Stains-all. The immobilization of oligonucleo= Walker, M. R. 299 tides and their hybridization proper• ; Woof, J. M.; Burton, D. R.; Brug= Urquhart, A. See Llewellyn, D. H. ties. 216 geman, M.; Jefferis, R. Urwin, N. A. R. A simple and efficient method for Immunoglobulin G subclass specificity ; Nicholl, D. S. T covalently attaching oligonucleotides of human Fc receptor II determined Analysis and cloning of Chlorella to a cellulose support matrix. 367 using human chimeric anti-5-io= fusca DNA: the effects of methyla= dio-4-hydroxy-3-nitroph en acetyl tion and repetitive sequences. 759 monoclonal antibodies. 725 Wade, V. See Ward, R. J. Walker, P. A. See Fairbrother, W. J. Wadsworth, J. D. F. Walker, R. A. See Rye, P. D. Vamecq, J. See Van Hoof, F. ; Shone, C. C; Meiling, J.; Dolly, J. AUTHOR INDEX 11

Walker, S. W. See Bird, I. M. from mammary glands of the lactat= Anti-Borrelia antibody in human Wallace, H. M. See Nuttall, M. E. ing rat. 285 Lyme disease. 161 Effect of NSD-1055 on BHK-21/C13 Wattiaux, R. See Carbonnelle, V. Williams, K. M. See Marshall, T. cells. 211 Wattiaux-De Coninck, S. See Car• Williams, R. Wallis, M. See Boyd, R. S. bonnelle, V. ; Howell, R. M. Walsh, C. Watton, J. Improved procedure for the purifica3 ; Distefano, M.; Moore, M. ; Docherty, M.; Bradford, H. F. tion of thromboplastin apoprotein Mutagenesis of paired cysteine resi= Membrane-bound glutamate decar= from porcine brain. 570 dues in the disulfide-containing boxylase may be present in synaptic Williams, R. J. P. See Fairbrother, flavoprotein mercuric ion reductase plasma membranes as an integral W. J.; Rowatt, E. from mercury-resistant bacteria. membrane protein. 321 The principles of molecular recogni= 90 Weakley, L. J. See Kashfi, K. tion. 923 Walsh, F. S. See Barton, C. H. Weaver, K. See Brammer, M. Williams, S. P. Walton, A. R. See Lindley, P. F. ; Campbell, I. C. ; Mason, R. M. Walton, F. See King, D. J. ß-Adrenoceptor desensitization stud• Effect of heparin on proteoglycan Walton, T. J. See Smith, C. J. ies in rat lung. 569 synthesis by proliferating vascular Walz, D. A. See Chegwidden, W. R. Webber, A. N. See Gray, J. C. smooth muscle cells. 17 Waqar, M. A. Wegener, G. See Schmidt, H. Williams, T. C. Simian virus 40 DNA replication in Weitzman, P. D. J. See Jenkins, T. ; Jarvis, S. M. vitro. 545 M.; Lloyd, A. J.; O'Neil, S.; Ruther• Further characterization of sodium-- Separation of replicating simian ford, D. M. dependent uridine transport in virus 40 chromosomes according to Wertman, E. See Michaelson, D. M. rabbit renal cortex. 768 extent of replication. 546 Wessel W. L. Williamson, D. J. See Khodr, H. Replicating simian virus 40 chromo= ; Clare, K. A.; Gibbons, W. A. Williamson, F. B. See Grant, D. some structure. 604 Purification and characterization of Williamson, R. A. Warburton, M. J. See Hayman, A. R. He toxin synthetase from Helmint- ; Worrall, S.; Chazot, P. L.; Strange Ward, J. B. See Gladwin, A. M. hosporium carbonum. 401 P. G. Ward, R. J. See O'Connell, M. J.; Biosynthesis of L-Aeo, the toxic de• Partial purification of the D2 dopa• Peters, T. J. terminant of the phytotoxin pro• mine receptor from bovine caudate ; Jutla, J.; Duane, P. D.; Peters, T. duced by Helminthosporium carbo= nucleus. 450 J. num. 402 Willis, R. G. See Baker, P. R.; Lind• Reduced antioxidant status in pa= West, D. W. See Shand, J. H.; Wal• say, R. M. tients with chronic alcoholic myopa= ters, C. D. Willmott, N. J. thy. 581 Fast atom bombardment-mass spec• ; Hussain, A. A.; Voaden, M. J. ; O'Connell, M. J.; Mann, S.; Wade, troscopy in the structural analysis Biochemical and electrophysiological V.; Dickson, D. P. E.; Reid, N.; of acidic peptides derived from abnormalities in the photoreceptors Bomford, A.; Peters, T. J. bovine caseins. 745 of mice heterozygous for the rd Heterogeneity of the iron cores in Westley, B. R. See Wiseman, L. R. gene. 1074 hepatic hemosiderins from primary Weston, A. H. See Duty, S. Willson, R. See Dorey, C. and secondary hemochromatosis. Wharton, C. W. See Chittock, R. S. Wilson, A. S. 830 Wheeler, K. P. See Parker, J. R. ; Phillips, J. D.; Birch, N. J. Wardale, R. J. See Maciewicz, R. A. Whelan, J. See Martin, F. Effects of lithium on mouse osteo• Wardlaw, A. C. Whish, W. J. D. See Sharif, M. A. clasts and on the biomechanical A science and engineering research White, C. J. B. See Sharif, M. A. properties of long bone in the rat. council perspective on the supervi= Whitehead, I. M. See Threlfall, D. R. 826 sion of research students and on Whitley, G. See Johnstone, A. Wilson, M. J. completion rates for Ph.D. thesis. ; Johnstone, A.; Nussey, S. ; Freedman, R. B.; Fitton, J. E. 117 An immortalized human thyroid cell Recovery, refolding and purification Warren, M. J. line, SGHTL-34, responsive to of recombinant «2-interferon. 58 ; Jordan, P. M. thyrotropin and autoantibodies. Wilton, D. See O'Connor, D.; Sheri• An absolute requirement for 5-ami- 196 dan, M. nolevulinic acid in the formation of Whittaker, P. A. See Kavanagh, K. Winder, F. G. See Shields, D. catalytically active porphobilinogen A. Winkler, M. A. See Dorr, A. W. deaminase. 962 Wibley, K. S. See Barlow, D. J. Winston, G. W. See Livingstone, D. Further evidence for the involvement Wickramasinghe, Y. A. B. D. See R. of a dipyrromethane cofactor at the Thorniley, M. S. Winter, P. C. active site of porphobilinogen deam• Wiech, H. See Mueller, G. ; Wisdom, G. B. inases. 963 Wigley, C. B. See Johnson, A. R. Detection of galactosyltransferase Watkins, W. J. See Rennie, P. J. Wikstroem, A. C. See Denis, M. isoenzymes by immunoblotting. Watkins, W. M. See Skacel, P. O. Wilcox, D. 158 Watmough, N. J. See Bartlett, K. ; Mason, R. W. Winterbourne, D. J. Watson, D. Identification of active cysteine pro• ; Thomas, S.; Stebbing, A.; Her= ; Murray, S.; Taylor, G. W.; Gower, teinases in cellular systems. 811 mon-Taylor, J. D. B.; Ruparelia, B.; Vinson, G. P.; Wilkin, G. P. See Cholewinski, A. J. A procedure for selection of cells Anderson, E. Wilkinson, R. with suppressed growth in suspen= Gas chromatography-electron capture ; Nicholls, D. sion after gene transfection. 1018 mass spectrometry of steroids of Compartmentation of calcium-de= Electroporation or electro-injection? human origin. 737 pendent pools of glutamate and 1018 Watson, H. A. aspartate in isolated cerebral corti• Wisdom, G. B. See Winter, P. C. ; Gooderham, N. J. cal nerve terminals by isotopic The determination of antibody clon= Polyriboinosinic acid»polyribocytidylic exchange and fractionation. 879 ality using biotinylated antigen. acid depresses mouse extrahepatic Wilkinson, S. E. See Davis, P. D. 158 cytochrome P-450 systems and Willcocks, A. L. See Cooke, A. M. Wise, P. H. See Lyons, P. A. alleviates chloroform nephrotoxicity Willey, D. L. See Gray, J. C. Wise, P. J. See Cooper, P. J. 631 Williams, A. C. See Bhatti, A. R. Wiseman, A. See Dorr, A. W.; Jafelice, Watson, H. C. See Fairbrother, W. J. Williams, A. J. See Crescenzi, K. L. L. R. S. Watson, J. See Langlands, J. M. Williams, B. C. See Bird, I. M. Wiseman, L. R. Watt, F. M. Williams, C. H. See Backwell, F. R. ; Wakeling, A. E.; May, F. E. B.; Proliferation and terminal differentia• C; Beattie, R. E.; Nunn, J. D. Westley, B. R. tion of human epidermal keratino= Williams, D. See Olufemi, O. S. Effects of the antiestrogen ICI 164,= cytes in culture. 666 Williams, D. G. 384 on estrogen-induced RNAs in Watt, W. B. See Grant, G. The immunoblot in autoimmune MCF-7 cells. 1063 Watters, C. D. connective tissue disease. 162 Withers, R. M. ; West, D. W. ; Muhlemann, M. F.; Wright, D. J. ; Buttery, P. J.; Haynes, N. B. Phosphorylation of Golgi membranes M. Evidence for the involvement of 1122 AUTHOR INDEX

glucocorticoids in the action of Woof, J. ML See Walker, M. R. between aldolase and phosphocellu- ß-agonists in sheep skeletal muscle. Woolf, D. A. See Davies, S. E. C. lose. 543 1073 Woolley, D. E. See Taylor, D. J. Yoshida, A. Witts, H. Wootton, J. C. See Jones, K. M. ; Hsu, L. C; Ikuta, T; Kikuchi, I.; ; Masterson, B. Worrall, S. See Williamson, R. A. Shibuya, A.; Mohandas, T. K. Library-user education at the second^ Wright, D. J. M. See Hayes, L. J.; Molecular genetics of alcohol-metab^ ary literature level for biochemistry Williams, D. G. olizing enzymes. 230 undergraduates. 379 Wright, D. W. See Patel, N. J. Young, D. See Mehlert, A. Wong, C. See Evans, R. W. Wu, Z. Young, D. B. Wonnacott, S. See Thome, B. ; Maddy, A. H. Immunoblotting and the immune Wood, A. M. See Morrison, J. N. Identification of antigens by high—= response to leprosy. 143 Wood, D. See Moreland, B. H. performance liquid chromatography Young, J. D. See Fincham, D. A. Wood, E. J. See Holland, D. B.; 769 Young, P. See Higgins, S. J. Owusu, S.; Raxworthy, M. J. Yaacob, H. B. See Piper, P. J. Biochemistry in the biological sci= Yahya, Z. A. H. ences undergraduate curriculum. ; Bates, P. C; Tirapegui, J. O.; Zaera, E. See Stubberfield, C. R. 509 Morrell, D.; Buchanan, C.; Millward, Zajdel, M. E. B. See Blair, G. E. ; Raxworthy, M. J.; Holland, D. B. D. J. Zeman, S. See Fletcher, E. J. Retinoids and the epidermis. 668 IGF-1 concentrations in protein Zhang, H. Woodley, J. F. deficient rat plasma and tissues in ; Hammer, J. L.; Thieret, R. L.; ; Prescott, A. R. relation to protein and proteoglycan Johnson, P. Effect of brain glycolipids and size synthesis rates. 624 Effects of calmidazolium on calpain on the uptake of distearylphosphati= Yaron, A. See Hendriks, D. activity and the calpain-calpastatin dylcholine/cholesterol liposomes by Yarranton, G. T. See King, D. J. interaction. 44 rat intestine in vitro. 342 Yasui, A. See Douglas, A. J. ; Johnson, P. Body distribution of liposome-en^ Yates, J. See Preedy, V. R. Effects of trifluoperazine, compounds trapped iodine-125-labeled insulin Yates, M. G. See Armstrong, F. A. W-7 and W-13 on chicken gizzard after oral administration to rats. Yea, C. M. See Cross, A. R. calpain II. 1043 343 Yeaman, G. R. See Kerr, M. A. Zhang, L. Woodman, A. C. Yeaman, S. J. See Small, C. A. ; Roberts, G. M.; Hallett, M. B. ; Gooderham, N. J. Yeoman, M. M. See Holden, M. A. Diphenyliodonium-sensitive killing Effects of polyriboinosinic acid«polyri= Yesufu, H. M. I. of K562 tumor cells by blood mono= bocytidylic acid administration on ; Kuo, Y. M.; Adams, R. L. P. nuclear cells. 902 mouse hepatic flavin-containing Nuclear DNA methylase from Pisum Zimmermann, R. See Mueller, G. mono-oxygenase activity. 630 sativum. 757 Zoeilner, N. See Sprandel, U. Woods, M. D. Yi, X. See Simpson, A. J. G. Zoetmulder, M. C. M. See Sudbery, ; Freshney, R. I.; Pilkington, G.; Yon, R. J. See Clark, T. R. P. E. Vaughan, P. F. T. Computer modeling of multivalent Zupanska, B. See Merry, A. H. Expression of receptors, linked to affinity partitioning. 542 cyclic AMP formation by cultures A reexamination of the interaction of human fetal astrocytes. 432 KEYWORD INDEX

Abnormal Acyltransferase chromatog protein engineering purifn antithrombin III plasma 374 cholesterol mammary pregnancy 111 Acetaldehyde lactation 1013 chromatog protein mitochondria liver toxicity liver review 241 lecithin cholesterol secretion hepato• 602 Acetate cyte 155 chromatog tyrosine protein kinase inorg ion liver 577 Adductor liver 780 Acetoacetate pollicis muscle fatigue atracurium partition protein computer simulation creatinine detn Jaffe reaction 549 336 542 Acetyl Adenine Agarose CoA carboxylase liver ale 580 nucleotide analog glutamate dehydro3 dansylaminodecyl affinity chromatog CoA chloramphenicol acetyltransfer3 genäse 861 protein 719 ase binding site 715 Adenoma Age Acetylation colon mucus glycoprotein carcinoma collagen metab heart 749 aminobenzoate blood erythrocyte 581 genetic diabetes enzyme thyroid hemolysis 1024 Adenosine hormone 31 aniline phenetidine blood 1071 cholinergic nerve terminal 442 Aging sulfamethazine blood erythrocyte kinase inhibitor cytotoxicity structure cell glycolysis growth 617 health diabetes 786 756 Ajmalicine Acetylbenzoquinoneimine vasodilation review 479 compartmentation vacuole Catharan3 toxicity hepatocyte dimethyl PGE2 Adenovirus thus 63 641 transformation antigen gene tran3 Alamethicin Acetylcholine scription 605 sodium efflux liposome 594 acidosis calcium salivary gland 993 Adenylate Alanine blood vessel inositol trisphosphate cyclase desensitization adrenergic glyoxylate aminotransferase liver 488 receptor internalization 308 hyperoxaluria 1 627 receptor gene cloning locust 463 Adhesion racemase inhibition vinylglycine synapse brain adenosine ATP 442 cell polystyrene surface hydration phosphonate analog 606 Acetylcholinesterase 1029 transport erythrocyte horse 567 immunocytochem localization sarco3 cell serum lipoprotein atherosclerosis transporter sodium protein proteoli3 lemma muscle 770 560 posome 344 Acetyltransferase Adhesive Ale blood erythrocyte health diabetes protein blotting analysis 144 acetyl CoA carboxylase liver 580 786 Adipocyte aldehyde dehydrogenase human ge3 blood hemolysis 1024 fetus brown culture lipogenesis 274 netics review 227 chloramphenicol active site review glucose oxidn bradykinin 1012 aldehyde dehydrogenase human review 939 Adipose 230 chloramphenicol CoA binding site brown mitochondria biochem cold antioxidant plasma myopathy 581 715 obesity 1009 calcium channel blocker vas deferens Acid ADP 381 collagenase osteoclastoma 1064 ribose poly formation inhibitor 869 calcium channel review 527 phosphatase tartrate resistant osteo3 ribose transferase tegument tapeworm carnitine palmitoyltransferase I liver clastoma 895 868 649 secretion stomach pertussis toxin ribosylation inhibitor NAD metab cytochrome c oxidn kinetics cold 281 869 846 Acidosis ribosylation protein botulin 883 dehydrogenase ethanol metab liver acetylcholine calcium salivary gland Adrenal 239 993 aldosterone formation dopamine 387 dehydrogenase isoenzyme review Aciduria chromaffin granule sodium proton 223 dicarboxylic glucuronide ester urine exchange 595 dehydrogenase NAD cofactor analog 744 congenital hyperplasia review 691 binding 862 Acinetobacter medulla secretory vesicle purifn 51 dependence glyceride liver review isocitrate dehydrogenase isoenzyme methylaminoethyl acetate neurovege3 251 AMP hysteresis 870 tative transmitter 565 glucose metab review 247 metabolic pathway evolution 153 steroidogenesis adrenaline angiotensin insulin endocytosis liver 573 Acne 983 liver toxicity acetaldehyde review keratin formation pilosebaceous duct Adrenaline 241 330 adrenal steroidogenesis 983 manuf review 1079 Acrosome Adrenergic metab microsome review 232 sperm hyaluronidase staining 643 agonist glucocorticoid muscle 1073 metabolizing enzyme genetics review Actin antagonist insulin secretion 1005 230 monoclonal antibody 163 receptor astrocyte cell 432 muscle bone circulation 576 substance P neuron nerve injury 465 receptor desensitization lung 569 protein muscle 571 Active receptor internalization adenylate toxicity cardiac muscle 783 site carbonic anhydrase III chicken cyclase desensitization 308 toxicity muscle review 250 974 Adsorption transferrin iron uptake hepatocyte site chloramphenicol acetyltransferase Chromobacter lipase heptane water 575 review 939 interface 273 tryptophan metab review 254 site dipyrromethane cofactor porpho3 cytochrome c peroxidase electrode Alcaligenes bilinogen deaminase 963 aminoglycoside 842 polyhydroxybutyrate polyhydroxyal3 site Klenow fragment replication Aeromonas kanoate formation enzyme 1046 fidelity 947 exoprotein antibody salmon brown Aldehyde site monoamine oxidase photoaffinity trout 999 ale dehydrogenase human genetics label 214 Affinity review 227 Acute chromatog dansylaminodecyl agarose ale dehydrogenase human review intermittent porphyria porphobilino3 protein 719 230 gen deaminase mRNA 799 chromatog dopamine D2 receptor dehydrogenase ethanol metab liver Acyl 450 239 carnitine detn urine plasma 796 chromatog glutamate binding protein dehydrogenase isoenzyme review CoA dehydrogenase review 416 446 223 CoA detn review 410

1123 1124 KEYWORD INDEX

dehydrogenase liver cytosol kinetics nase formation 962 auto DNA helper T lymphocyte 148 mechanism 856 857 synthase liver antidepressant 847 auto immunoblotting connective Aldolase Aminopeptidase tissue disease 162 detection tetrazolium salt electropho= brain inhibition amino acid 849 auto thyroid cell line 196 resis 750 dipeptidyl IV T lymphocyte stimula= Borrelia protein detection immunob^1 detn tetrazolium salt 753 tion 365 lotting 161 glyceraldehyde phosphate dehydroge^ leucine brain cortex human 850 calsequestrin prepn 380 nase reaction coupling 752 leucine inhibition leucine thioamide differentiation antigen monocyte phosphocellulose interaction model 185 Chemotaxis inhibition 966 543 leucine inhibition methylleucine E allergenicity lactoglobulin rat 338 Aldosterone chloromethyl ketone 186 Fc region effector function review formation dopamine adrenal 387 Aminotransferase 953 Alfalfa alanine glyoxylate liver hyperoxaluria G protein receptor review 434 medicarpin elicitation calcium 1069 1 627 monoclonal actin 163 Algae aspartate phosphonate substrate monoclonal ATPase inhibition sarco= lipid heavy metal 275 analog 611 plasmic reticulum 967 Aliph Ammonia monoclonal ATPase sarcoplasmic substrate aldehyde dehydrogenase lyase phenylalanine calcium phytoa= reticulum 771 856 lexin 1069 monoclonal brain tumor cell 373 Alk Ammonium monoclonal cerbB2 oncogene protein phosphatase uterus pregnancy 848 transport Aspergillus 969 675 picrate creatinine glucose spectra AMP monoclonal creatinine kinase epitope 394 isocitrate dehydrogenase hysteresis localization 717 picrate glucose creatinine 395 Acinetobacter 870 monoclonal idiotypy IgGl Fc region picrate glucose spectra 393 nucleotidase adenosine vasodilation 747 soln bilirubin spectrophotometry review 479 monoclonal leukemia cell 376 550 Amylase neurofilament antigen Alzheimer Alkali alpha Penicillium fermn property disease 855 oxyHb heme stability 386 181 ovalbumin signal peptide 36 Alkaloid fermn Clostridium 184 phosphoprotein phosphatase modula• recovery plant cell culture review 67 Amyloglucosidase tor 720 Alkylamine Penicillium fermn 181 protein mitochondria biliary cirrhosis long chain phospholipase A2 inhib= Amylolytic 151 ition 816 enzyme Penicillium fermn 181 purifn immunoblotting Sepharose Allergenicity Anchor chromatog 134 milk lactoglobulin rat 338 phosphoatidylinositol membrane repertoire detn biotinylated antigen Allosuppressor enzyme detergent solubilization 158 gene SAL3 SAL4 Saccharomyces 30 583 response infection immunoblotting Alpaca Androgen 132 detn wool fiber mixt 639 gonadotropin pituitary LH RH 170 Staphylococcus protein endocarditis Alveolar receptor regulation fibroblast skin 997 macrophage collagenase 391 172 ubiquitin protein detection nucleus Alzheimer responsive gene 695 1059 disease antibody neurofilament anti= Androstene Anticholinergic gen 855 metabolite bacteria axilla 738 drug platelet aggregation factor 815 disease brain analysis death 472 Androstenone Anticonvulsant polyphosphoinositide ornithine decar= detn electron capture mass spectros= carbamazepine inositol lipid hydroly^ boxylase cholinergic denervation copy 737 sis hippocampus 986 467 Angiotensin Antidepressant Amine adrenal steroidogenesis 983 aminolevulinate synthase liver 847 oxidase plasma MPTP analog 335 converting enzyme brain synaptosome Antigen Amino 191 biotinylated antibody repertoire detn acid decarboxylase detn plant ext liver metab 636 158 972 Anhydrase carcinoembryonic colon tumor inters acid inhibition aminopeptidase brain carbonic expression liver region 572 feron 1049 849 carbonic III activation phosphate carcinoembryonic receptor endocyto^ acid metab transamination history 853 sis Kupffer cell 1027 600 carbonic III active site chicken 974 class I gene transcription transforma^ acid neurotransmitter function aspar= carbonic lipogenesis grasshopper 973 tion 605 täte 315 Aniline detn gel chromatog antibody 769 acid parenteral heart protein forma• acetylation blood 1071 differentiation antibody monocyte tion 782 transacetylation phenacetin blood Chemotaxis inhibition 966 acid replacement transferrin variant 742 histocompatibility DNA autoantibody 834 Animal formation 148 acid sequencing blotted protein 140 cell polyphosphoinositide phosphodi= leprosy immunoblotting review 143 acid sulfur aspartate uptake brain esterase PMA 994 lymphocyte activation assocd protein 302 cell selection suppressed growth 383 acid transport erythrocyte harmaline 1018 mitochondria peptide mapping immu= 567 species sodium ileum muscle contract noblotting 151 Aminobenzoate tion 588 neurofilament Alzheimer disease acetylation blood erythrocyte hemoly• Anion antibody 855 sis 1024 binding blood plasma NMR 714 protein immunoelectroblotting mito= Aminoepoxyoxodecanoate prealbumin interaction Remazol chondria heart 53 formation Helminthosporium synthe= Yellow GGL 603 protein staining immunoblotting tase 402 Anoxia single gel 149 Aminoglycoside calcium glutamate synaptosome 880 Rh monoclonal IgG leukocyte rosette Azotobacter flavodoxin electrochem Antibody 727 graphite electrode 959 Aeromonas exoprotein salmon brown Schistosoma carbohydrate immunity cytochrome c peroxidase graphite trout 999 264 electrode 842 antigen detn gel chromatog 769 Sm nRNP autoantibody detection Aminoimidazoarene apolipoprotein E glycoprotein IRBP immunoblotting 162 mutagen microsome activation inhib= 318 Antioxidant ition methylxanthine 620 auto clonality thyroglobulin autoim= cell oxygen uptake detn 284 Aminolevulinate mune thyroiditis 728 729 heparan extracellular matrix disease requirement porphobilinogen deami= auto DNA clonality time course 147 977 plasma ethanol myopathy 581 KEYWORD INDEX 1125

Antirheumatic Assessment 341 drug interleukinl synovial cell 892 monitoring research student project neutropenia neutrophil FcR 732 Antiserum 118 thyroiditis thyroglobulin autoantibody fibroblast extracellular protein 375 Astrocyte clonality 728 729 G protein receptor review 434 cell receptor adrenergic purinergic Autophosphorylation Antithrombin 432 site insulin receptor kinase 1065 III Dublin 2 variant plasma 374 development nerve cell 295 Autoreceptor Antitrypsin peptide receptor 429 glutamate brain synaptosome 881 mRNA monocyte tumor necrosis trophic factor cholinergic neuron Autoxidn factor 1055 296 oxyHb alkali heme stability 386 Aorta Atherosclerosis Avocado constriction pyruvate dehydrogenase hypercholesterolemia diabetes rabbit oxoacyl acyl carrier protein reductase heart 772 lipoprotein blood 200 392 media lipid distribution senescence lipoprotein serum cell adhesion 560 Axilla 164 plaque collagen glycosaminoglycan bacteria androstene metabolite 738 proteoglycan detection 159 rupture 1033 Axon Apoglycerol Atherosclerotic retina ganglion cell regeneration dehydrogenase reactivation zinc Ba3 plaque cap connective tissue 1032 laminin 440 cillus 975 Atomic Azotobacter Apolipoprotein absorption spectroscopy lithium ferredoxin I redox potential 840 E antibody glycoprotein IRBP 318 transport erythrocyte 827 flavodoxin electrochem graphite E rich lipoprotein receptor platelet ATP electrode aminoglycoside 959 154 adenosine cholinergic nerve terminal Bacillus surfactant lung metab 276 442 apoglycerol dehydrogenase reactiva• Apoprotein cation insulin receptor kinase regula• tion zinc 975 thromboplastin purifn brain 570 tion 40 endotoxin interaction liposome 39 Applied synthase phosphorylation bifurcation plasmid maintenance expression 194 biol education biochem 587 hysteresis 645 plasmid stability gene expression Arachidonate synthase presequence mitochondrial 192 lipoxygenase inhibition ketotifen targeting 709 Bacteria 814 thylakoid protein phosphorylation alpha glucosidase specificity reclassi3 metab corticosteroid leukocyte 279 fluorescence 46 fication 184 synovium interleukin 1 286 ATPase androstene metabolite axilla 738 Arginine Aspergillus proton ammonium trans• evolution immunoelectroblotting 153 active site carbonic anhydrase III port 969 protein disulfide isomerase 57 974 inhibition thiocyanate methylphenyl- protein inclusion body purifn 102 cleavage atriopeptin carboxypeptidase methoxyimidazopyridineacetonitri- Bacterioferritin N 359 le stomach 27 structure Escherichia 836 glucagon secretion pancreas 1017 peripheral nervous tissue galactosemia Barium iso 1 cytochrome c structure 844 diabetes 306 calcium sensitive dehydrogenase Arom potassium site photoaffinity labeling mitochondria 590 substrate aldehyde dehydrogenase stomach 823 Barley 856 sarcoplasmic reticulum inhibition inhibitor human platelet aggregation Aromatase monoclonal antibody 967 19 ovary placenta inhibition ketoconazole sarcoplasmic reticulum monoclonal Base 29 antibody 771 exchange pathway phospholipid for3 Arsenazo sarcoplasmic reticulum oleate 347 mation channelling 1036 III lipopolysaccharide cation binding self assocn lipid membrane 346 Bass 716 structure function liposome 914 liver glucose phosphate dehydroge3 Artery transport nerve diabetes mellitus nase inactivation 903 contraction calcium phenylephrine 878 Batten 493 Atracurium disease dolichol linked oligosaccharide endothelium derived relaxing factor adductor pollicis muscle fatigue 336 brain 1031 486 neuromuscular blockade glycopyrro3 Beer pulmonary sarcoplasmic reticulum late atropine neostigmine 746 protein electrophoresis 167 sarcolemma sepn 356 neuromuscular junction laudanosine Beneckea Arthritis 336 microbiol education 767 cathepsin B L synovial fluid 812 toxicity liver 614 Benzamide rheumatoid collagen hydroxypyridini3 Atrial ADP ribosylation inhibition 869 urn crosslink urine 817 natriuretic peptide receptor heart Benzoate Arylamide 1022 metab fish 24 deacetylation reacetylation blood Atriopeptin metab metabolite review 1021 743 arginine cleavage carboxypeptidase N Benzodiazepine Arylamine 359 receptor ganglion grasshopper 310 transacetylation blood 742 cGMP review 490 Benzopyrene Aspartate receptor heart sarcolemma 1022 metab Mytilus microsome oxygen amino acid neurotransmitter function Atrophy radical 779 315 retina cGMP taurine Tibetan terrier Beryllium aminotransferase phosphonate sub• 317 tyrosine phosphorylation 1047 strate analog 611 Atropine Beta brain nerve terminal 879 neostigmine neuromuscular blockade bend pyrrolidinone gastrin peptide essential glutamate dehydrogenase atracurium 746 175 Escherichia 874 ATTT oxidn fatty acid intermediate review glycated urine 29 consensus sequence gene human 410 transcarbamoylase essential tyrosine mouse 366 oxidn fatty acid review 418 wheat germ 615 Autoantibody Betaine uptake brain sulfur amino acid 302 clonality thyroglobulin autoimmune urine newborn development 788 Aspergillus thyroiditis 728 729 Bethanechol carbon metab 791 DNA clonality time course 147 pepsin gastric juice 26 growth lipase esterase 790 DNA helper T lymphocyte 148 Beverage NADP glycerol dehydrogenase bicar• Sm nRNP antigen detection immu= ale manuf review 1079 bonate 976 noblotting 162 Bicarbonate proton ammonium transport 969 thyroid cell line 196 iron binding transferrin review 825 Assembly Autoimmune NADP glycerol dehydrogenase Asper3 self myosin phosphorylation filament disease human idiotype distribution gillus 976 regulation 501 1126 KEYWORD INDEX

secretion stomach thiocyanate nonenzymic glycated protein cataract potassium channel phencyclidine methylphenylmethoxyimidazopyri= 648 analog 200 dineacetonitrile 27 oxygenation detn spectrometry 978 protein reconstitution liposome extru= Bifurcation plasma anion binding NMR 714 sion 352 ATP synthase phosphorylation hys= platelet aggregation pyridoxal phos= succinate thiokinase metabolic role teresis 645 phate 385 795 Bile platelet calcium lipoprotein 287 synaptosome polyphosphoinositide acid breast cyst fluid 741 serum galactosyltransferase isoenzyme carbachol depolarization 320 acid hepatocyte culture cholesterol detection 158 synaptosome sepn centrifugation diet 1001 vessel inositol trisphosphate acetyl^ neurotransmitter 309 acid liver low density lipoprotein choline 488 thromboplastin apoprotein purifn 566 vessel purine nucleotide review 480 570 salt dihydroxy trypsinogen trypsin vessel relaxation cGMP 497 tumor cell monoclonal antibody 373 inhibitor 168 vessel smooth muscle proteoglycan Branched Biliary heparin 17 chain phospholipid liposome phase cirrhosis antibody mitochondria pro= Blotting transition 348 tein 151 analysis adhesive protein 144 Breast Bilirubin protein gel isoelec focusing 154 cancer cathepsin B like enzyme 192 creatinine detn Jaffe reaction 551 protein receptor ligand interaction cancer EGF receptor hormone 173 spectrophotometry alk soln 550 138 cancer human estrogen mRNA cDNA Biliverdin Southern DNA detection probe 139 169 reductase chloride substrate inhibition Western proteoglycan detection 159 cyst fluid bile acid 741 403 Bone tumor glycoprotein hormone 1026 Binding long osteoclast development newborn Bromodeoxyuridine protein gene receptor androgen pros= lithium 826 neg selection CHO cell 1018 täte 695 muscle circulation ethanol 576 Bronchoalveolar Biochem Borrelia fluid collagenase elastase sarcoidosis applied biol education 587 protein antibody detection immunob^ 390 education biol science undergraduate lotting 161 fluid fibronectin tobacco smoke 378 509 511 segmented DNA genome 544 Brown education undergraduate curriculum Botulin adipocyte fetus culture lipogenesis 513 A light chain heavy chain 886 274 engineering education 516 A protein phosphorylation nerve 885 adipose mitochondria biochem cold example phys science education 508 ADP ribosylation protein 883 obesity 1009 history UK 507 Bradford trout Aeromonas exoprotein antibody neurochem periodical 599 membrane protein detn detergent 999 phys science education 515 382 Brush Biog Bradykinin border iron uptake carrier size 832 Plimmer 601 glucose oxidn adipocyte 1012 border kidney calcium metab gentam= Biol Brain icin 213 applied education biochem 587 acetylcholine synapse adenosine ATP border kidney lipid peroxidn iron 20 mol education computer 764 442 border membrane protein proteolipo= mol education model simulation 765 aminopeptidase inhibition amino some 344 science undergraduate biochem edu= acid 849 border uridine transport kidney sodi= cation 509 511 angiotensin converting enzyme synap= urn 768 Bioluminescence tosome 191 Butylbicyclophosphorothionate phosphate dependence lux gene aspartate uptake sulfur amino acid GABA receptor ganglion insect 475 Streptococcus 1068 302 B16F10 Biomedical calmodulin dependent phosphoprotein cell adhesive protein blotting 144 science postgraduate education New phosphatase detn 297 Cadmium Zealand 120 cortex leucine aminopeptidase human glutathione midgut gland Procamba= Biotinylated 850 rus 23 antigen antibody repertoire detn 158 cyclic nucleotide phosphodiesterase insulin receptor kinase 896 Biotinylation formation 212 Calcitonin proteoglycan detection 159 cytosol microsome luliberinase 209 recombinant secretion yeast review Bird diacylglycerol lipase 293 1083 erythrocyte taurine transport stoi= dolichol linked oligosaccharide Batten Calcium chiometry 555 disease 1031 acetylcholine acidosis salivary gland hydroxy steroid dehydrogenase liver dopamine D2 receptor purifn 450 993 microsome 22 enkephalin mRNA 313 activation nucleoside diphosphatase Bisadenosyl glutamate binding protein sepn 446 Golgi 561 tetraphosphatase interaction substrate glutamate release presynaptic regular artery contraction phenylephrine analog 713 tion 881 493 Bladder glutathione transferase subunit 386 binding protein p9Ka gene rat 1061 neoplasm diagnosis glucose phosphate glycogen Phosphorylase hypoxia fish binding protein rod outer segment dehydrogenase 555 621 299 Blood growth cone neurotransmitter calcium binding protein thin filament 355 aminobenzoate acetylation hemolysis 444 calpain II conformation calmodulin 1024 high mol wt multicatalytic protease 1045 aniline phenetidine acetylation 1071 852 carbonate crystn membrane interface arylamide deacetylation reacetylation methylaspartate receptor thienylcy- 824 743 clohexylpiperidine 300 channel alpha2 subunit carbohydrate arylamine transacetylation 742 nerve terminal glutamate aspartate 452 cell plasma metallothionein I inflam= 879 channel blocker ethanol vas deferens mation 820 neurochem detn postmortem 472 381 erythrocyte sulfamethazine acetylation neurotensin degrdn metalloendopepti^ channel ethanol review 527 health diabetes 786 dase 851 channel smooth muscle review 492 fibrinogen human genetics 541 oxygenation detn IR spectrometry creatine kinase muscle hypoxia ultra^ fucosyltransferase leukemia chemo= 980 structure 1052 therapy substrate 1034 parvalbumin mRNA localization 313 epidermis keratin 327 IgG copper deficiency diet lactose periaqueductal grey morphine chole= erythrocyte membrane potassium 54 cystokinin 538 transport neomycin 598 lipoprotein hypercholesterolemia polyphosphoinositide ornithine decar= glutamate synaptosome brain 879 diabetes atherosclerosis rabbit boxylase cholinergic denervation glutamate synaptosome ischemia 200 467 anoxia hypoglycemia 880 KEYWORD INDEX 1127

heparin interaction model 1028 Candida Cataract homeostasis excitable cell review estradiol binding protein 789 nonenzymic glycated protein blood 519 recycle xylose fermn ethanol 198 lens 648 hormone vascular relaxation cGMP Capsaicin Catharanthus 497 prodn Capsicum culture 66 ajmalicine compartmentation vacuole hydroxytryptamine synaptosome Capsicum 63 sodium 803 culture capsaicin prodn 66 cell culture serpentine 65 isoprenaline heart respiration glycoly• Carbachol Cathepsin sis 591 polyphosphoinositide depolarization B L synovial fluid arthritis 812 leukemia cell SRI 62 834 278 brain synaptosome 320 B like enzyme breast cancer 192 LH RH protein kinase C 597 Carbamazepine L B detection cell culture 811 lung parenchyma 35 inositol lipid hydrolysis hippocampus L precursor activation 1056 metab kidney brush border gentami- 986 Cation ein 213 Carbohydrate ATP insulin receptor kinase regula3 mitochondria function review 523 antigen Schistosoma immunity 264 tion 40 mobilization cell inositol trisphospho- binding proacrosin sperm 1035 binding arsenazo III lipopolysacchar— rothioate 995 calcium channel alpha2 subunit 452 ide 716 neurotransmitter growth cone brain diet glucose phosphate dehydrogenase exchange intestine contraction harma• 444 899 line 589 neutrophil cytosol activation threshold Carbon Cattle 37 metab Aspergillus 791 DNase gene cloning 195 phytoalexin phenylalanine ammonia tetrachloride toxicity liver interferon Caudate lyase 1069 632 nucleus enkephalin mRNA 313 platelet low density lipoprotein 287 13 serine enzymic prepn 179 cCMP pump phosphoprotein Golgi mam= Carbonic phosphodiesterase effector sensitivity mary 285 anhydrase expression liver region liver 774 receptor muscle nerve review 520 572 cDNÄ release myoinositol diphosphate phos= anhydrase III activation phosphate citrate synthase yeast cloning Eschert phorothioate 992 853 ichia 718 sensitive dehydrogenase barium mito• anhydrase III active site chicken 974 diacylglycerol lipase brain 293 chondria 590 anhydrase lipogenesis grasshopper estrogen mRNA human breast cancer sodium exchange cardiovascular har• 973 169 maline review 539 Carboxykinase heat shock protein human 174 sodium exchange excitable cell review phosphoenolpyruvate hepatocyte NCAM glycoprotein sequence human 529 gluconeogenesis propionate sheep 457 sodium exchange intestine contraction 204 nicotinic acetylcholine receptor clon= 589 Carboxyl ing locust 463 thin filament review 494 group binding site glutamate deny3 probe epitope enolase human 305 transport endothelium derived relax• drogenase 860 protein PGP95 enolase human neuron ing factor 486 Carboxylase 454 transport salivary inositol phosphate acetyl CoA liver ale 580 Cefotaxime fly 988 Carboxylate resistance Enterobacter beta lacta• trypsinogen activation immunoassay transition metal ion complex depro- mase kinetics 404 337 tonation 406 Cell Caldesmon Carboxylation adhesion polystyrene surface hydra• muscle contraction regulation 360 pyruvate dexamethasone vasopressin tion 1029 Calliphora liver 1075 aging glycolysis growth 617 salivary potential oscillation inositol Carboxypeptidase calcium mobilization inositol trisphos- phosphate 988 N atriopeptin arginine cleavage 359 phorothioate 995 Calmidazolium Carcinoembryonic culture Catharanthus serpentine 65 calpain calpastatin 44 antigen colon tumor interferon 1049 culture cathepsin L B detection 811 Calmodulin antigen receptor endocytosis Kupffer culture plant product recovery review antagonist calpain II 1043 cell 1027 67 calpain II conformation calcium Carcinoma differentiation inositol phosphate 1045 mucus glycoprotein colon adenoma 985 dependent phosphoprotein phospha• 581 division plasmid loss 193 tase detn fluorometry 297 Cardiac envelope filaggrin skin newborn 324 function cystic fibrosis 345 vascular muscle regulation 503 epithelium transformation oncogene NAD metab tegument tapeworm Cardiovascular fos 1019 868 sodium calcium exchange harmaline growth polyamine NSD 1055 211 thin filament calcium sensitivity 355 review 539 immunoaffinity partition 968 Calpain system leukotriene review 482 membrane ischemia protein lipid calpastatin calmidazolium 44 Career 537 II calmodulin antagonist 1043 opportunity postgraduate student nerve astrocyte development 295 II conformation calcium calmodulin 128 proliferation thymidine kinase leakage 1045 Carnitine 55 Calpastatin acyl detn urine plasma 796 selection suppressed growth 1018 calpain calmidazolium 44 metab insulin liver starvation 1014 transformation electroporation elec- Calsequestrin palmitoyltransferase I liver ethanol troinjection 1018 muscle sarcoplasmic reticulum 380 649 Cellulose cAMP palmitoyltransferase liver mitochond3 immobilization oligonucleotide 367 astrocyte peptide receptor 429 ria membrane diabetes 1010 Central histamine stomach parietal cell 808 Cartilage nervous system myelin protein immu- lipoprotein receptor fibroblast vein proteoglycan hyaluronate binding nochem 614 1008 fragment 188 nervous system protein kinase C 307 noradrenaline occipital cortex 311 Casein Centrifugation platelet calcium lipoprotein 287 alpha gene mapping mouse 624 chromosome replication sepn 546 protein kinase activity ratio detn beta gene rabbit 623 endoplasmic reticulum liver 34 355 bound lactoferrin milk 215 protein inclusion body 102 thyroid polyamine 397 gene sequence mouse 1064 sucrose secretory vesicle purifn 51 Cancer sequence phosphoserine localization synaptosome sepn brain neurotran• breast cathepsin B like enzyme 192 745 smitter 309 breast EGF receptor hormone 173 Catalase CerbB2 human breast estrogen mRNA cDNA model dinuclear manganese oxide oncogene protein monoclonal antibody 169 complex 822 675 skin retinoid review 668 1128 KEYWORD INDEX

Cerebral 201 enterotoxin gene cloning 1069 cortex enkephalin degrading metallo= reverse transport spleen 282 glutamate dehydrogenase substrate peptidase 405 serum copper deficiency lactose diet site lysine 875 cGMP 54 CoA blood vessel relaxation 497 Cholinergic acyl detn review 410 calcium hormone vascular relaxation denervation polyphosphoinositide binding site chloramphenicol acetyl^ 497 ornithine decarboxylase brain 467 transferase 715 nitrovasodilator review 490 nerve terminal adenosine ATP 442 Codon retina atrophy Tibetan terrier 317 neuron antigen Alzheimer disease initiation interferon gene mutation Channel 855 Escherichia 48 blocker calcium ethanol vas deferens neuron astrocyte trophic factor 296 Coenzyme 381 Chondrocyte site glycerol dehydrogenase Bacillus calcium alpha2 subunit carbohydrate potassium transport 637 976 452 proline transport sodium 894 Cold calcium smooth muscle review 492 Chorionic cytochrome c oxidn kinetics ale 846 gap junction function review 534 gonadotropin immunosuppression protein GDP mitochondria obesity potassium regulation review 532 horse 793 1009 Channelling Chromaffin Collagen phospholipid endoplasmic reticulum granule sodium proton exchange gene structure review 661 1036 adrenal 595 glycosaminoglycan atherosclerosis Cheese Chromatog plaque rupture 1033 protein electrophoresis 165 affinity dansylaminodecyl agarose hydroxypyridinium crosslink urine Chelator protein 719 rheumatoid arthritis 817 metal computer modeling 835 affinity dopamine D2 receptor 450 lattice contraction fibroblast metab Chemiluminescence affinity glutamate binding protein 328 assay modulating factor phagocyte 446 like quaternary structure pullulanase 289 affinity protein computer model 542 Klebsiella 722 Chemotaxis affinity protein engineering purifn meat cooking 169 monocyte inhibition antibody differ^ 111 metab heart age 749 entiation antigen 966 affinity protein mitochondria liver muscle growth hormone 177 Chemotherapy 602 platelet aggregation fatty acid isomer leukemia fucosyltransferase 1034 affinity tyrosine protein kinase liver 291 Chicken 780 structure assembly skin review 663 monkey estrogen receptor gene clon= gel antigen detn antibody 769 Collagenase ing 388 liq acyl carnitine 796 acid osteoclastoma 1064 progesterone receptor gene 683 liq fast protein DNA 368 alveolar macrophage 391 Chloramphenicol liq iron heme protoporphyrin 831 dermis equiv remodeling 326 acetyltransferase active site review liq thromboplastin apoprotein 570 elastase bronchoalveolar fluid sarcoi• 939 Sepharose antibody purifn immunob= dosis 390 acetyltransferase CoA binding site lotting 134 Colon 715 Chromobacter adenoma mucus glycoprotein carcino^ Chlorella lipase adsorption heptane water inters ma 581 DNA cloning mapping 759 face 273 tumor growth inhibition interferon Chloride Chromosome 1049 biliverdin reductase substrate inhib= human 766 Colorimetry ition 403 replication sepn centrifugation 546 nucleoside diphosphatase detn Golgi channel butyibicyclophosphorothion^ 21 Down syndrome gene 171 561 ate ganglion insect 475 Cimaterol Compartmentation flux GABAergic inhibition insecticide glucocorticoid muscle 1073 ajmalicine vacuole Catharanthus 63 303 Circulation Complement Chloroform muscle bone ethanol 576 Clq receptor purifn monocyte 735 kidney toxicity polyriboinosinic poly= Cirrhosis C3 fragment biol fluid PAGE 160 ribocytidylic acid 631 biliary antibody mitochondria protein Completion Chloromethyl 151 rate PhD research student supervision methylleucine ketone inhibition leu= primary biliary antigen mitochondria 117 cine aminopeptidase 186 53 Computer Chloroplast Citrate education mol biol 764 assembly disassembly mechanism synthase cDNA yeast cloning Eschert modeling metal chelator 835 Festuca 1053 ichia 718 protein sequence analysis education cytochrome f senescence Festuca Class 764 1054 I antigen gene transcription transform simulation protein affinity partition gene transcription photoregulation mation 605 542 review 711 Clonidine Conduction membrane protein gene review 704 noradrenaline cAMP occipital cortex block frog electromagnetic stimulation protein processing assembly review 311 1020 703 seminal vesicle contraction phenyl Conformation Chloroquine lephrine potassium 1021 calpain II calcium calmodulin 1045 insulin receptor liver 1040 Cloning glucose phosphate dehydrogenase CHO citrate synthase cDNA yeast Escher= NADP NADPH 903 cell transformant selection 1018 ichia 718 protein gamma turn review 50 Cholecystokinin DNase gene cattle 195 protein PGP95 nerve review 323 morphine brain periaqueductal grey enterotoxin gene Clostridium 1069 Congenital 538 estrogen receptor gene chicken mon= adrenal hyperplasia review 691 Cholera key 388 Connective toxin diacylglycerol insulin fibroblast lux gene Vibrio Lactobacillus Strepto= tissue atherosclerotic plaque cap 283 coccus 1068 1032 Cholesterol mapping DNA Chlorella 759 tissue disease autoantibody immunob= acyltransferase mammary pregnancy mol eukaryote protein Escherichia lotting 162 lactation 1013 review 108 Consensus diet hepatocyte culture bile acid nicotinic acetylcholine receptor cDNA sequence ATTT gene human mouse 1001 locust 463 366 lecithin acyltransferase secretion restriction mapping casein gene Contraction hepatocyte 155 mouse 624 muscle myosin phosphorylation regu• lymphocyte mitogenesis 202 Clostridium lation review 499 metab sympathetic nervous system amylase fermn 184 KEYWORD INDEX 1129

Cooking 958 ria 590 meat collagen elastin 169 c b5 interaction NMR 844 dihydrolipoamide membrane trans3 Copper c b5 plastocyanin complex electrochem port function review 87 binuclear complex monooxygenase 957 glucose phosphate detn urine neoplasm model 821 c iso 1 structure arginine 844 555 deficiency lactose diet immunity 54 c oxidn kinetics ale cold 846 glucose phosphate hormone liver 33 insulin receptor kinase 896 c peroxidase graphite electrode ami• glucose phosphate NADP NADPH Cornea noglycoside 842 conformation 903 eye keratan sulfate distribution 333 f chloroplast senescence Festuca glucose Thermoplasma 864 Corticosteroid 1054 glutamate carboxyl group binding arachidonate metab leukocyte 279 NADPH reductase Escherichia 872 site 860 Cortisol oxidase IR spectrometry brain 980 glutamate Escherichia lysine 876 prostate growth 389 oxidase IR spectrometry organ 978 glutamate essential lysine Escherichia Cotransport P 450 liver organ 642 874 sodium phosphate proximal tubule P 450 yeast genotoxicity review 1086 glutamate pyridoxal phosphoadenine 353 P450 mutagen activation inhibition nucleotide 861 Coumarin methylxanthine 620 glutamate substrate site lysine Clos3 deriv lysosome disease diagnosis P450 Saccharomyces oxygen 370 tridium 875 review 11 P450 tissue polyriboinosinic polyribo- glyceraldehyde phosphate aldolase Creatine cytidylic acid 631 reaction coupling 752 kinase muscle hypoxia ultrastructure Cytokine glyceraldehyde phosphate gene retro3 calcium 1052 skin immunoregulation review 677 poson Trypanosoma 1067 Creatinine synovial cell glycolysis 889 glyceraldehyde phosphate resonance detn Jaffe reaction 393 395 Cytoprotection Raman 49 detn Jaffe reaction acetoacetate 549 dimethyl PGE2 hepatocyte 641 glycerate liver hyperoxaluria 2 626 detn Jaffe reaction bilirubin 550 Cytosol glycerol apo reactivation zinc Bacillus 551 brain luliberinase 209 975 glucose alk picrate spectra 394 calcium neutrophil activation thresh3 hydroxy steroid liver microsome bird kinase epitope localization monoclon• old 37 22 al antibody 717 liver aldehyde dehydrogenase kinetics IMP GMP reductase homol Escheric3 Cryokinetics mechanism 856 857 hia 858 cytochrome c oxidn ale 846 liver platelet aggregation inhibitor isocitrate heart mitochondria 873 Cryoprotectant 898 isocitrate isoenzyme AMP hysteresis erythrocyte liposome 354 Cytotoxicity Acinetobacter 870 Crystal adenosine kinase inhibitor structure isocitrate NAD Methylophilus 871 structure bacterioferritin Escherichia 756 lactate fibroblast dodecylimidazole 836 Dairy 43 structure ferritin light chain mutant product protein electrophoresis 165 lactate isoenzyme purifn heart liver 838 Dansylaminodecyl 18 structure refinement glutathione agarose affinity chromatog protein liver development 899 reductase review 81 719 mandelate Rhodotorula 865 Crystn Deacetylation NADP glycerol bicarbonate Aspergil3 calcium carbonate membrane inter• reacetylation arylamide blood 743 lus 976 face 824 Deaminase phosphogluconate interference hexok3 protein lattice contact 961 porphobilinogen dipyrromethane inase detn 867 Culture cofactor active site 963 pyruvate fatty acid plasma 553 axon regeneration substratum compn porphobilinogen formation aminole3 pyruvate heart aorta constriction 440 vulinate requirement 962 772 fetus brown adipocyte lipogenesis porphobilinogen mRNA acute inter3 pyruvate lipoyl group desensitization 274 mittent porphyria 799 ethylmaleimide 775 hepatocyte bile acid cholesterol diet Death pyruvate liver starvation refeeding 1001 brain analysis Alzheimer disease 472 773 oligodendrocyte differentiation cyclic Decarboxylase pyruvate Saccharomyces 776 nucleotide phosphohydrolase 900 amino acid detn plant ext 972 sorbitol erythrocyte diabetes mellitus plant terpene formation review 61 glutamate synaptic membrane bound 363 Curriculum 321 xanthine tissue ischemia 358 undergraduate biochem education ornithine brain cholinergic denerva3 Demyelinating 513 tion 467 disease metalloproteinase myelin Cyanocinnamate ornithine epidermis psoriasis 329 469 affinity chromatog protein liver 602 Decarboxylation Denaturation Cyclase pyruvate dexamethasone vasopressin prochymosin reversibility purifn 59 adenylate desensitization adrenergic liver 1075 Dense receptor internalization 308 Defibrotide vesicle phosphodiesterase activation Cyclic endothelium function 540 protein kinase 1025 nucleotide phosphodiesterase forma• Deglycosylation Dephosphorylation tion brain neuroglia 212 dihydropyridine receptor calcium enzyme glycogen formation liver 579 nucleotide phosphohydrolase oligo• channel subunit 452 Depolarization dendrocyte differentiation culture Degranulation carbachol polyphosphoinositide brain 900 response neutrophil development synaptosome 320 nucleotide phosphohydrolase se3 128 Deprotonation quence homol mammal 304 Dehydrogenase carboxylate transition metal ion com3 Cyst acyl CoA deficiency 796 plex 406 breast fluid bile acid 741 acyl CoA flavoprotein review 416 Dermis Cysteine ale aldehyde human review 230 equiv contraction fibroblast metab essential mercuric reductase site ale aldehyde isoenzyme review 223 328 mutation 90 ale ethanol metab liver 239 equiv remodeling collagenase 326 proteinase active form detection cell aldehyde ale human genetics review Desaturase 811 227 linoleate liver PCB species 1072 Cystic aldehyde liver cytosol kinetics media3 Desensitization fibrosis calmodulin function 345 nism 856 857 adenylate cyclase adrenergic receptor Cystine binding NAD cofactor analog 862 internalization 308 fibroblast dodecylimidazole 43 binding theazolecarboxamide adenine Desmin Cytochrome dinucleotide 862 intermediate filament monoclonal bl structure Escherichia 836 calcium mitochondria review 523 antibody 52 b5 electrochem peptide gold electrode calcium sensitive barium mitochond3 1130 KEYWORD INDEX

Desuccinylation Dinuclear D2 receptor purifn brain 450 hydroxymethylglutarylCoA synthase manganese oxide complex model prolactin secretion G protein 887 glucagon mannoheptulose 633 catalase 822 Down Desulfovibrio Dipeptide syndrome chromosome 21 gene 171 hydrogenase inactivation mercurial uptake lysosome mechanism 42 Drug 178 Dipeptidyl carrier liposome erythrocyte review Detergent aminopeptidase IV T lymphocyte 917 membrane protein detn Bradford stimulation 365 delivery liposome review 910 382 Diphenyleneiodonium design protein blotting 138 protein detn turbidimetry 640 superoxide oxidase inhibition phago= Dysplasia solubilization membrane enzyme cyte 888 rod hereditary photoreceptor biochem phosphoatidylinositol anchor 583 Diphosphatase electrophysiol 1074 Development nucleoside detn calcium activation Dysprosium betaine urine 788 Golgi 561 shift reagent lithium NMR biochem liver dehydrogenase 899 Dipyrromethane 207 osteoclast long bone newborn lithium cofactor active site porphobilinogen D2 826 deaminase 963 dopamine receptor purifn brain 450 testosterone metab liver bird 22 cofactor formation aminolevulinate Ectonucleotidase Dexamethasone porphobilinogen deaminase 962 acetylcholine synapse brain 442 glutamine synthetase liver region Disease Education 572 diagnosis DNA Southern blotting postgraduate biomedical science New pyruvate metab liver 1075 139 Zealand 120 Dextran heparan extracellular matrix antioxi= postgraduate Europe 122 iron liver subcellular processing 854 dant 977 postgraduate student view 125 PEG phase microsome partition 34 lysosome diagnosis fluorescence review Efflux Diabetes 11 sodium liposome alamethicin hemoly^ ATPase peripheral nervous tissue skin eicosanoid review 680 sin melittin 594 galactosemia 306 Dismutation EFTu carnitine palmitoyltransferase liver superoxide heparin 1030 elongation factor kirromycin interact mitochondria membrane 1010 Disulfide tion 761 genetic malic enzyme thyroid hor= bond glutathione reductase review EGF mone 31 81 enzyme mammary gland lactation health sulfamethazine acetylation isomerase protein mechanism function 778 blood erythrocyte 786 review 96 histamine cAMP parietal cell 808 hypercholesterolemia rabbit lipopro^ isomerase protein solubilization mi= peptide structure activity review 671 tein blood atherosclerosis 200 crosome 58 phenylalanine hydroxylation liver mellitus ATPase transport nerve protein isomerase lymphocyte matu^ insulin 897 878 ration 56 prostate growth 389 mellitus complication polyol pathway redox mechanism thioredoxin glutare= receptor breast cancer hormone 173 363 doxin 95 Eicosanoid phenylalanine hydroxylase liver Dithiothreitol lipoxygenase substrate inhibition 38 mRNA 1057 protein mitochondria solubilization skin review 680 succinate thiokinase insulin 795 53 Elastase Diacylglycerol DMN collagenase bronchoalveolar fluid acetylcholine blood vessel 488 oncogene expression liver 1058 sarcoidosis 390 insulin cholera toxin fibroblast 283 DNA Elastin lipase brain 293 autoantibody clonality time course meat cooking 169 Diagnosis 147 Electroblotting disease DNA Southern blotting 139 autoantibody helper T lymphocyte adhesive protein 144 disease lysosome fluorescence review 148 IgG lab expt 762 11 binding specificity FNR protein Es= Electrochem Diaphragm cherichia 755 Azotobacter fiavodoxin graphite neuromuscular transmission tubocu= cloning mapping Chlorella 759 electrode aminoglycoside 959 rarine 747 detection Southern blotting probe cytochrome b5 peptide gold electrode rat twitch tetanic fatigue 382 139 958 Dicarboxylate fast protein liq chromatog 368 protein complex graphite electrode metab mitochondria peroxisome 423 hybridization oligodeoxyribonucleo- 957 Dicarboxylic tide immobilization 216 Electrode aciduria glucuronide ester urine 744 initiator protein REP D tyrosine gold peptide cytochrome b5 electro^ Dienoyl 758 chem 958 CoA reductase review 420 methylase pea 757 graphite Azotobacter fiavodoxin Differentiation methylase type I evolution review electrochem aminoglycoside 959 antigen antibody monocyte chemotax= 942 graphite cytochrome c peroxidase is inhibition 966 methyltransferase structure mammal aminoglycoside 842 keratinocyte review 666 944 graphite protein complex electrochem oligodendrocyte culture cyclic nucleo^ polymerase Klenow fragment replica= 957 tide phosphohydrolase 900 tion fidelity 947 Electroinjection Digestion replication SV40 virus 545 cell transformation 1018 phaseolin peptidase 612 resolvase mechanism substrate supers Electromagnetic Dihydrofolate coiling 760 stimulation conduction block frog reductase mutation mol recognition resolvase mechanism transposon Tn3 1020 ligand 925 754 Electron Dihydrolipoamide segmented genome Borrelia 544 capture mass spectroscopy steroid dehydrogenase membrane transport SV40 virus replication structure 604 detn 737 function review 87 DNase transport flavoprotein review 416 Dihydropyridine gene cattle cloning 195 Electrophoresis receptor calcium channel subunit Dodecylimidazole aldolase detection tetrazolium salt deglycosylation 452 cystine lactate dehydrogenase fibrob^ 750 Dihydroxy last 43 gel adhesive protein 144 bile salt trypsinogen trypsin inhibitor Dolichol IgG lab expt 762 168 formation Trypanosoma review 268 milk protein 165 Dimethylhexadecanoylphosphatidylchol= linked oligosaccharide brain Batten protein beer 167 ine disease 1031 wool silver staining 639 liposome phase transition 348 Dopamine Electroporation aldosterone formation adrenal 387 cell transformation 1018 KEYWORD INDEX 1131

Elongation ornithine decarboxylase psoriasis dependence glyceride liver review factor EFTu kirromycin interaction 329 251 761 retinoid review 668 fatly acid synthase liver 580 Encapsulation Epidermolytic glucose metab review 247 glucosidase erythrocyte 1051 toxin binding epidermis 334 heart muscle protein formation 783 Endocarditis Epithelium insulin endocytosis liver 573 Staphylococcus protein antibody cell transformation oncogene fos liver toxicity acetaldehyde review 997 1019 241 Endocytosis rat mammary p9Ka gene mRNA metab liver ale dehydrogenase 239 carcinoembryonic antigen receptor 1061 metab microsome review 232 Kupffercell 1027 reproductive tract reprogramming muscle bone circulation 576 fibrinopeptide macrophage fibronectin gene expression 810 protein muscle 571 559 Epitope toxicity muscle review 250 insulin liver ethanol 573 enolase cDNA probe human 305 transferrin iron uptake hepatocyte transferrin iron transport hepatocyte localization creatinine kinase mono• 575 618 clonal antibody 717 tryptophan metab review 254 Endonuclease Erythrocyte xylose fermn Pachysolen Candida restriction type I evolution review amino acid transport harmaline 567 recycle 198 942 aminobenzoate acetylation hemolysis Ethylmaleimide Endoplasmic 1024 pyruvate dehydrogenase lipoyl group reticulum liver partition centrifuga— blood sulfamethazine acetylation desensitization 775 tion 34 health diabetes 786 Etomoxir reticulum phospholipid formation cryoprotectant 354 ketone body metab 797 channelling 1036 drug carrier review 917 Eukaryote reticulum protein import review 708 glucosidase encapsulation 1051 protein expression solubilization Endosome immunoaffinity partition 968 refolding Escherichia 108 insulin degrdn liver 574 iron oxygen radical 292 Evolution Endothelium lithium transport 205 bacteria immunoelectroblotting 153 derived relaxing factor cGMP review lithium transport NMR 827 ferret mammal Hb sequence 608 490 membrane potassium transport calci• GMP reductase IMP dehydrogenase derived relaxing factor inositol phos= um neomycin 598 Escherichia 858 phate 486 peptide transport detn NMR 635 mandelate dehydrogenase microor• derived relaxing factor review 484 peroxide oxygen uptake detn 284 ganism 865 function defibrotide 540 phosphate compartmentation 781 type I restriction enzyme review 942 vascular acetylcholine inositol diacyl= sorbitol dehydrogenase diabetes mel= Exchange glycerol 488 litus 363 sodium proton adrenal chromaffin Endotoxin taurine transport stoichiometry pigeon granule 595 Bacillus interaction liposome 39 555 Excitable Engineering Erythropoietin cell calcium homeostasis review 519 biochem education 516 RIA submaxillary gland 564 cell sodium calcium exchange review protein purifn affinity chromatog Escherichia 529 111 bacterioferritin structure 836 Exoprotein Enkephalin citrate synthase cDNA yeast cloning Aeromonas antibody salmon brown degrading metallopeptidase cerebral 718 trout 999 cortex 405 eukaryote protein expression solubili3 Exotoxin mRNA brain 313 zation refolding 108 enzyme Staphylococcus osteomyelitis Enolase FNR protein DNA binding specificity 1000 cDNA probe epitope human 305 755 Explosion protein PGP95 cDNA human neuron glutamate dehydrogenase essential enzyme hysteretic hormone action 454 lysine 874 562 Enterobacter glutathione reductase mechanism 84 Explosive beta lactamase kinetics cefotaxime GMP reductase IMP dehydrogenase reaction hormone action 562 resistance 404 homol 858 Expt Enterotoxin inclusion body 101 IgG electrophoresis electroblotting gene Clostridium cloning 1069 interferon gene expression 48 762 Enzyme NADP glutamate dehydrogenase Extension ale metabolizing genetics review 230 lysine 876 Capsicum culture capsaicin prodn amylolytic Penicillium fermn 181 NADPH cytochrome reductase 872 66 benzoate metab review 1021 protein inclusion body recovery 102 Extracellular dephosphorylation glycogen formation recombinant prochymosin purifn matrix heparan antioxidant disease liver 579 112 977 exotoxin Staphylococcus osteomyelitis ribonucleotide reductase large subunit protein fibroblast antiserum 375 1000 review 91 Extrusion fatty acid beta oxidn review 418 uroporphyrinogen III synthase 965 brain protein reconstitution liposome hysteretic hormone action explosion Esterase 352 562 lipase growth Aspergillus 790 Eye lipogenic liver hormone 33 Estradiol cornea keratan sulfate distribution malic genetic diabetes 31 binding protein Candida 789 333 mammary gland lactation EGF 778 Estrogen retina calcium binding protein 299 plasma immunoblotting review 140 detn electron capture mass spectros3 Factor polyhydroxybutyrate polyhydroxyal - copy 737 EFTu kirromycin interaction 761 kanoate formation Alcaligenes mRNA cDNA human breast cancer III apoprotein pptn 570 1046 169 Fast proteoglycan detection 159 receptor gene cloning chicken monkey protein liq chromatog DNA 368 reactor biochem engineering education 388 Fasting 516 receptor gene human 388 insulin processing liver 1041 Enzymic RNA ICI 164384 mammary neoplasm Fatigue prepn carbon 13 serine 179 1063 twitch tetanic rat diaphragm 382 Enzymol Ethanol Fatness oxidn 409 antioxidant plasma myopathy 581 genetics insulin lipogenesis 1037 Epidermis calcium channel blocker vas deferens Fatty epidermolytic toxin binding 334 381 acid beta oxidn enzyme review 410 keratin calcium vitamin A 327 calcium channel review 527 acid beta oxidn intermediate review keratin hydroxyvitamin D3 psoriasis carnitine palmitoyltransferase I liver 410 331 649 acid beta oxidn review 418 1132 KEYWORD INDEX

acid binding protein purifn liver 719 drolysis 987 GABAergic acid fluidity microsome pyrene 349 lipoprotein receptor cAMP 1008 chloride flux inhibition insecticide acid formation Fusilade inhibition metab collagen lattice contraction 303 mechanism 277 328 Galactosemia acid isomer platelet aggregation colla= Fibronectin ATPase peripheral nervous tissue gen 291 bronchoalveolar fluid tobacco smoke diabetes 306 acid liver fructose bisphosphate 378 Galactoside 1015 fibrinopeptide endocytosis macros beta extracellular Paecilomyces 183 acid metab hepatocyte glucagon phage 559 Galactosyltransferase 1007 Fibrosis isoenzyme detection immunoblotting acid metab hepatocyte sheep 203 cystic calmodulin function 345 158 acid metab liver hormone 1002 Filaggrin Gamma acid oxidn defect mitochondria review cell envelope skin newborn 324 turn review protein conformation 50 424 Filament Ganglion acid plasma pyruvate dehydrogenase intermediate desmin monoclonal benzodiazepine receptor grasshopper 553 antibody 52 310 acid polyunsatd blood platelet aggre= myosin phosphorylation self assembly butylbicyclophosphorothionate GABA gation 385 regulation 501 receptor insect 475 acid polyunsatd oxidn mechanism thin calcium binding protein 355 cell retina axon regeneration laminin review 420 Fish 440 acid short chain prostaglandin syn= glycogen Phosphorylase brain hypoxia Gap thase 398 621 junction channel function review acid substrate inhibition lipoxygenase phenoxybenzoate metab 24 534 38 Fiavodoxin Gastric acid synthase component plant 392 Azotobacter electrochem graphite acid secretion gastrin analog 628 acid synthase liver ethanol 580 electrode aminoglycoside 959 juice pepsin pentagastrin bethanechol Fc Flavoprotein 26 receptor function leukocyte lipocortin electron transport review 416 mucin subunit size 585 1 730 superoxide oxidase inhibition diphe^ Gastrin receptor IgG subtype monocyte 734 nyleneiodonium 888 analog gastric acid secretion 628 receptor monoclonal IgG Rh antigen Fluid peptide pyrrolidinone beta bend 175 733 complement C3 fragment biol 160 Gastrocnemius receptor subtype IgG isotype binding Fluorescence muscle conduction block frog 1020 725 activated cell sorting receptor 363 GDP region antibody effector function lysosome disease diagnosis review 11 binding mitochondria cold obesity review 953 thylakoid ATP protein phosphoryla= 1009 region IgGl monoclonal antibody tion 46 Gel idiotypy 747 Fluorescent chromatog antigen detn antibody FcR probe pyrene fluidity microsome 349 769 neutrophil autoimmune neutropenia Fluorometry electrophoresis adhesive protein 144 732 calmodulin dependent phosphoprotein electrophoresis app 762 Fenpropimorph phosphatase detn 297 isoelec focusing blotting protein 154 fungicidal activity membrane permea= Fly Gelatinase bility 350 salivary potential oscillation inositol gingiva fibroblast 893 Fermenter phosphate 988 Gene biochem engineering education 516 FNR acetylcholine receptor locust cloning Fermn protein DNA binding specificity 463 amylolytic enzyme Penicillium 181 Escherichia 755 active inactive nucleosome micrococ= beta galactosidase Paecilomyces 183 Folding cal nuclease 1060 Ferredoxin tailspike maturation aggregation aldehyde ale dehydrogenase human I redox potential Azotobacter 840 phage P22 105 review 227 Ferret Follicle alpha casein mapping mouse 624 Hb beta chain sequence 608 fluid ovary inhibin 212 androgen responsive 695 Ferritin Fos ATTT consensus sequence human hemosiderin 828 oncogene epithelium cell transforma= mouse 366 iron liver hemochromatosis hemoside• tion 1019 beta casein rabbit 623 rin 830 Frog calcium binding protein p9Ka 1061 Ferrochelatase conduction block electromagnetic casein mouse sequence 1064 detnHPLC 831 stimulation 1020 cerbB2 protein monoclonal antibody Festuca Fructose 675 chloroplast assembly disassembly bisphosphate liver substrate 1015 chloroplast transcription photoregula= mechanism 1053 Fucosyltransferase tion review 711 cytochrome f chloroplast senescence blood leukemia cell chemotherapy chromosome 21 Down syndrome 171 1054 substrate 1034 class I antigen transcription transfor• Fetus Fungi mation 605 astrocyte receptor adrenergic puri= fatty acid beta oxidn review 418 collagen structure review 661 nergic 432 He toxin synthetase 401 DNase cattle cloning 195 brown adipocyte culture lipogenesis Fungicidal EGF receptor hormone cancer 173 274 activity fenpropimorph membrane enterotoxin Clostridium cloning Fibrinogen permeability 350 1069 blood human genetics 541 Fusilade estrogen receptor cloning chicken Fibrinopeptide inhibition mechanism fatty acid for= monkey 388 endocytosis macrophage fibronectin mation 277 estrogen receptor human 388 559 Fusion expression plasmid stability Bacillus Fibroblast membrane osmotic force 882 192 androgen receptor regulation skin G expression reproductive tract epitheli= 172 protein hormone receptor review urn reprogramming 810 cell aging glycolysis 617 434 437 glyceraldehyde phosphate dehydroge= , cystine lactate dehydrogenase dode= protein prolactin growth hormone nase retroposon Trypanosoma cylimidazole 43 887 1067 diacylglycerol insulin cholera toxin GABA growth hormone glucocorticoid re^ 283 calcium growth cone brain 444 sponse 176 extracellular protein antiserum 375 receptor butylbicyclophosphorothion= hemolysin Vibrio 638 gingiva gelatinase 893 ate ganglion insect 475 heterologous expression Hansenula growth factor phosphoinositide hy= receptor grasshopper 310 review 1081 KEYWORD INDEX 1133

hspl08 protein human 174 phosphate dehydrogenase detn urine Glycerate interferon expression Escherichia 48 neoplasm 555 dehydrogenase liver hyperoxaluria 2 lux Vibrio cloning Lactobacillus phosphate dehydrogenase hormone 626 Streptococcus 1068 liver 33 Glyceride lymphokine expression human RNase phosphate dehydrogenase Leuconos3 liver ethanol dependence review 251 367 toe hexokinase detn 867 Glycerol parvalbumin expression brain 313 phosphate dehydrogenase liver devel• dehydrogenase apo reactivation zinc progesterone receptor chicken 683 opment 899 Bacillus 975 prolactin growth hormone regulation phosphate dehydrogenase NADP NADP dehydrogenase bicarbonate rat 699 NADPH conformation 903 Aspergillus 976 protein PGP95 structure review 323 phosphate glycogen cycling muscle Glycinebetaine protein p68 sequence lipocortin 813 uremia 578 cryoprotectant erythrocyte liposome SAL3 SAL4 allosuppressor Saccharo3 refeeding starvation liver glycogen 354 myces 30 579 Glycoconjugate UDP glucuronosyltransferase isoen• refeeding starvation skin glycogen parasite mammal review 257 zyme human liver 157 332 Glycodeoxycholate Genetic transporting protein microvessel trypsinogen trypsin inhibitor 168 diabetes malic enzyme thyroid hor• liposome 352 Glycogen mone 31 Glucosidase formation liver gluconeogenic precur3 recombination mechanism resolvase alpha specificity reclassification bac3 sor 579 754 teria 184 glucose phosphate cycling muscle recombination resolvase DNA super- alpha Streptomyces maltase sepn uremia 578 coiling 760 specificity 180 muscle hyperthyroidism starvation transformation cell selection 1018 encapsulation erythrocyte 1051 refeeding rat 554 Genetics Phanerochaete 369 Phosphorylase brain hypoxia fish ale metabolizing enzyme review 230 Glucuronide 621 aldehyde ale dehydrogenase human ester dicarboxylic aciduria urine 744 skin glucose refeeding starvation 332 review 227 Glucuronosyltransferase Glycolipid antithrombin III Dublin 2 374 UDP isoenzyme gene human liver anchor VSG protein membrane 996 fibrinogen blood human 541 157 liposome uptake intestine 342 insulin lipogenesis fatness 1037 UDP liver hypothyroidism substrate Glycolipoprotein Genome 802 VSG formation Trypanosoma 996 human sequence mapping 766 Glutamate Glycolysis segmented DNA Borrelia 544 binding protein sepn brain 446 cell aging growth 617 Genotoxicity brain nerve terminal 879 heart isoprenaline calcium 591 yeast cytochrome P 450 review 1086 decarboxylase synaptic membrane synovial cell lymphokine cytokine Gentamicin bound 321 889 calcium metab kidney brush border dehydrogenase carboxyl group binding Glycoprotein 213 site 860 breast tumor hormone 1026 Gingiva dehydrogenase Escherichia lysine formation Trypanosoma review 268 fibroblast gelatinase 893 876 IRBP apolipoprotein E antibody Gland dehydrogenase essential lysine Es• 318 midgut Procambarus glutathione cherichia 874 mucus colon adenoma carcinoma cadmium 23 dehydrogenase NAD cofactor analog 581 Glia binding 862 NCAM sequence human 457 protein kinase C TPA 294 dehydrogenase pyridoxal phosphoade- Tamm Horsfall kidney review 547 Gliadin nine nucleotide 861 Trypanosoma review 257 alpha wheat gluten isoelec focusing dehydrogenase substrate site lysine variant surface formation Trypanoso3 748 Clostridium 875 ma review 261 Glucagon receptor solubilization methylaspar3 variant surface glycolipid formation fatty acid metab hepatocyte 1007 täte quisqualate 314 Trypanosoma 996 hydroxymethylglutarylCoA synthase release brain presynaptic regulation variant surface membrane anchor liver 633 881 review 265 phenylalanine hydroxylation EGF synaptosome calcium ischemia anoxia VSG eukaryote phospholipase review liver 897 hypoglycemia 880 271 secretion arginine pancreas 1017 Glutamine Glycopyrrolate triiodothyronine lipogenic enzyme synthetase expression liver region neostigmine neuromuscular blockade liver 33 572 atracurium 746 Glucocorticoid Glutamyltranspeptidase Glycosaminoglycan adrenergic agonist muscle 1073 midgut gland Procambarus cadmium collagen atherosclerosis plaque rup3 insulin sensitivity muscle 174 23 ture 1033 receptor heat shock protein review Glutaredoxin rod outer segment phagocytosis 319 688 redox mechanism property review Glycosylation response growth hormone gene 176 95 IgG4 heterogeneity 340 Gluconeogenesis Glutathione lecithin cholesterol acyltransferase liver angiotensin 636 midgut gland Procambarus cadmium secretion hepatocyte 155 propionate hepatocyte sheep phos3 23 Glycosylphosphatidylinositol phoenolpyruvate carboxykinase reductase mechanism Escherichia 84 eukaryote membrane protein review 204 reductase structure mechanism review 271 Gluconeogenic 81 membrane anchor Trypanosoma precursor glycogen formation liver transferase subunit brain 386 review 265 579 Gluten Glyoxylate Glucose wheat alpha gliadin isoelec focusing reductase liver hyperoxaluria 2 626 alk picrate creatinine 395 748 Glyoxysome alk picrate spectra 393 Glycated formation protein body review 706 creatinine alk picrate spectra 394 aspartate lysine urine 29 GMP dehydrogenase Thermoplasma 864 protein blood lens cataract 648 reductase IMP dehydrogenase homol insulin carnitine liver starvation Glyceraldehyde Escherichia 858 1014 pancreas GTP insulin 809 Gold liver fructose bisphosphate 1015 phosphate dehydrogenase aldolase electrode peptide cytochrome b5 metab ethanol review 247 reaction coupling 752 electrochem 958 oxidn bradykinin adipocyte 1012 phosphate dehydrogenase gene retro3 Golgi pancreas GTP insulin 809 poson Trypanosoma 1067 membrane protein phosphorylation parenteral heart protein formation phosphate dehydrogenase resonance mammary lactation 285 782 Raman 49 nucleoside diphosphatase detn calcium activation 561 1134 KEYWORD INDEX

Gonadoliberin sarcolemma atriopeptin receptor Histocompatibility pituitary gonadotropin androgen 170 1022 antigen DNA autoantibody formation Gonadotropin Heat 148 chorionic immunosuppression horse shock protein cDNA human 174 HL60 793 shock protein glucocorticoid receptor cell biochem granulocyte model 400 pituitary LHRH androgen 170 review 688 HOE33258 Gossypol Heavy neg selection CHO cell 1018 tumor cell respiration uncoupler 616 metal insulin receptor protein kinase Hormone Granule 896 action explosive reaction 562 secretion platelet protein phosphory= metal lipid algae 275 calcium mitochondria function review lation 804 Helminthosporium 523 Granulocyte aminoepoxyoxodecanoate formation glycoprotein breast tumor 1026 model HL60 cell biochem 400 synthetase 402 growth gene glucocorticoid response Graphite He toxin synthetase 401 176 electrode Azotobacter fiavodoxin Helper growth prolactin gene regulation rat electrochem aminoglycoside 959 T lymphocyte DNA autoantibody 699 electrode cytochrome c peroxidase 148 lipogenic enzyme liver 33 aminoglycoside 842 Heme protooncogene prostate growth 389 electrode protein complex electrochem iron protoporphyrin HPLC 831 receptor activation review 437 957 stability oxyHb alkali 386 receptor G protein review 434 Grasshopper Hemochromatosis sensitive lipase heart 1038 benzodiazepine receptor ganglion iron hemosiderin ferritin liver 830 thyroid genetic diabetes 31 310 Hemolysin vascular relaxation calcium cGMP lipogenesis carbonic anhydrase 973 delta sodium efflux liposome 594 497 Growth gene Vibrio 638 Horse cell NSD 1055 211 Hemolysis alanine transport erythrocyte 567 cone neurotransmitter calcium brain aminobenzoate acetylation blood placenta immunosuppressive factor 444 erythrocyte 1024 793 hormone G protein 887 Hemosiderin HPLC hormone gene glucocorticoid response ferritin 828 ion exchange oligodeoxyribonucleotide 176 iron liver hemochromatosis ferritin 368 hormone muscle collagen 177 830 iron heme protoporphyrin 831 hormone prolactin gene regulation HEP reversed phase acyl carnitine 796 rat 699 G2 hepatoma mixed function oxidase HSP90 lipase esterase Aspergillus 790 801 protein interaction glucocorticoid GTP Heparan receptor review 688 pancreas insulin nutrient 809 extracellular matrix antioxidant dis— Human Guanidinobenzoatase ease 977 acute intermittent porphyria 799 inhibitor tumor 556 Heparin ale aldehyde dehydrogenase review Guinea calcium interaction model 1028 230 pig ileum contraction sodium 588 superoxide dismutation 1030 aldehyde ale dehydrogenase genetics Hansenula Hepatocyte review 227 heterologous gene expression review culture bile acid cholesterol diet autoimmune disease idiotype distri= 1081 1001 bution 341 Harmaline fatty acid metab sheep 203 breast cancer estrogen mRNA cDNA amino acid transport erythrocyte gluconeogenesis propionate sheep 169 567 phosphoenolpyruvate carboxyki- enolase cDNA probe epitope 305 cardiovascular sodium calcium ex= nase 204 estrogen receptor gene 388 change review 539 inositol trisphosphate detn 991 genetics fibrinogen blood 541 intestine contraction cation exchange iron transport transferrin endocytosis genome sequence mapping 766 589 618 leucine aminopeptidase brain cortex Hb lecithin cholesterol acyltransferase 850 beta chain sequence ferret 608 secretion 155 lymphokine gene expression RNase inositol hexaphosphate phosphorus paracetamol toxicity methylprosta— 367 31 NMR 839 glandin E2 641 mouse gene ATTT consensus se^ He transferrin iron uptake ethanol 575 quence 366 toxin synthetase Helminthosporium Hepatoerythropoietic NCAM glycoprotein sequence 457 401 porphyria biochem pathophysiol 829 neuron protein PGP95 enolase cDNA Health Hepatoma 454 hazard antidepressant porphyria 847 HEP G2 mixed function oxidase 801 platelet aggregation inhibitor barley Heart HepG2 19 calcium sensitive dehydrogenase cell lipoprotein receptor detn 363 protein hspl08 gene 174 barium mitochondria 590 Heptane Hyaluronate collagen metab age 749 water interface Chromobacter lipase binding proteoglycan fragment carti^ hormone sensitive lipase 1038 adsorption 273 läge 188 kallikrein kinin system ischemia Hereditary Hyaluronidase 1011 rod dysplasia photoreceptor biochem sperm acrosome staining 643 lactate dehydrogenase isoenzyme electrophysiol 1074 Hybridization purifn 18 Hexokinase DNA oligodeoxyribonucleotide immo• leukotriene vasoconstriction 361 detn phosphogluconate dehydrogenase bilization 216 mitochondria isocitrate dehydrogenase interference 867 Hybridoma 873 High infected mycoplasma elimination mitochondria protein antigen immu= mol wt multicatalytic protease brain mouse 398 noelectroblotting 53 852 Hydration muscle protein formation ethanol mol wt nonlysosomal proteinase liver polystyrene surface cell adhesion 783 629 1029 muscle regulation 503 Hippocampus Hydrogenase protein formation parenteral amino inositol lipid hydrolysis anticonvul^ inactivation mercurial Desulfovibrio acid 782 sant carbamazepine 986 178 pyruvate dehydrogenase aorta con= Histamine Hydrogenated striction 772 cAMP stomach parietal cell 808 oil platelet aggregation collagen 291 pyruvate dehydrogenase fatty acid Histochem Hydroxy 553 hexokinase phosphogluconate dehy= steroid dehydrogenase liver micro= respiration glycolysis calcium isopre^ drogenase interference 867 some bird 22 naline 591 KEYWORD INDEX 1

Hydroxylase Ileum optic nerve axon regeneration laminin phenylalanine liver mRNA diabetes muscle contraction sodium animal 440 1057 species 588 Inorg Hydroxylation Immobilization ion liver acetate 577 phenylalanine liver EGF insulin 897 oligodeoxyribonucleotide DNA hy• Inositol Hydroxymethylase bridization 216 hexaphosphate Hb phosphorus 31 serine prepn 179 oligonucleotide cellulose 367 NMR 839 Hydroxymethylglutaryl Immunity lipid hydrolysis hippocampus carba3 CoA reductase sympathetic system copper deficiency lactose diet 54 mazepine anticonvulsant 986 201 Mycobacterium stress protein 721 metab nerve mollusk 316 HydroxymethylglutarylCoA Schistosoma carbohydrate antigen phosphatase myelocyte 557 synthase glucagon mannoheptulose 264 phosphate cell differentiation 985 liver 633 Immunoaffinity phosphate endothelium derived relax3 Hydroxytryptamine partition erythrocyte 968 ing factor 486 synaptosome sodium calcium 803 Immunoassay phosphate formation neutrophil Hydroxyvitamin trypsinogen activation calcium 337 thrombin 280 D3 psoriasis epidermis keratin 331 Immunoblotting phosphate lung parenchyma contrac3 Hymenolepis antibody purifn Sepharose chromatog tion 35 tegument NAD metab calmodulin 134 phosphate PGF2alpha ras neoplastic 868 antibody response infection 132 transformation 990 Hyperalgesia antigen protein staining single gel phosphate salivary potential oscilla3 protein kinase C prostaglandin 818 149 tion Calliphora 988 Hypercholesterolemia autoantibody Sm nRNP antigen tetrakisphosphate vasopressin 984 diabetes rabbit lipoprotein blood detection 162 trisphosphate acetylcholine blood atherosclerosis 200 Borrelia protein antibody detection vessel 488 Hyperoxaluria 161 trisphosphate detn hepatocyte 991 1 alanine glyoxylate aminotransferase enzyme protein plasma review 140 trisphosphate tetrakisphosphate liver 627 galactosyltransferase isoenzyme de• microsome liver 593 2 liver enzyme 626 tection 158 trisphosphorothioate calcium mobili3 Hyperplasia leprosy antigen review 143 zation cell 995 adrenal congenital review 691 peptide antigen mitochondria 151 Insect Hyperthyroidism protein review 131 ganglion butylbicyclophosphorothion3 glycogen muscle starvation refeeding Immunocytochem ate GAB A receptor 475 rat 554 localization acetylcholinesterase sar• Insecticide Hypoglycemia colemma muscle 770 GABAergic chloride flux inhibition calcium glutamate synaptosome 880 Immunoelectroblotting 303 Hypothalamus evolution bacteria 153 Insulin TRH processing prostate 784 protein antigen mitochondria heart bradykinin glucose adipocyte 1012 Hypothyroidism 53 carnitine metab liver starvation UDP glucuronosyltransferase liver Immunoregulation 1014 substrate 802 skin cytokine review 677 degrdn endosome liver 574 Hypoxia Immunosuppression diacylglycerol cholera toxin fibroblast glycogen Phosphorylase brain fish placenta protein 14 interleukin 2 283 621 794 endocytosis liver ethanol 573 muscle creatine kinase ultrastructure Immunosuppressive fatty acid metab liver 1002 calcium 1052 factor placenta horse 793 IG Fl plasma tissue protein proteogly Hysteresis IMP can 624 ATP synthase phosphorylation bifur3 dehydrogenase GMP reductase homol lipogenesis genetics fatness 1037 cation 645 Escherichia 858 liposome oral distribution 343 isocitrate dehydrogenase AMP Acine3 Import pancreas GTP nutrient 809 tobacter 870 protein endoplasmic reticulum review phenylalanine hydroxylation liver Hysteretic 708 EGF 897 enzyme hormone action explosion Inclusion processing liver fasting 1041 562 body Escherichia 101 pyruvate dehydrogenase refeeding ICI body protein purifn bacteria 102 773 164384 estrogen RNA mammary Indium receptor chloroquine liver 1040 neoplasm 1063 interaction transferrin ovotransferrin receptor kinase autophosphorylation Idiotype 833 site 1065 distribution human autoimmune Indolepropionylleucylaspartylphenethyl- receptor kinase zinc cadmium copper disease 341 amide 896 Idiotypy stomach acid secretion 628 receptor tyrosine kinase regulation monoclonal antibody IgG 1 Fc region Infection liver 40 747 antibody response immunoblotting secretion adrenergic antagonist 1005 IgA 132 secretion intracellular pH 807 receptor neutrophil opsonization 731 Inflammation sensitivity glucocorticoid muscle 174 IGF1 metallothionein I 820 succinate thiokinase diabetes 795 insulin plasma tissue protein proteo• Inherited Interface glycan 624 defect fatty acid oxidn review 424 heptane water Chromobacter lipase IgG Inhibin adsorption 273 blood copper deficiency diet lactose ovary follicle fluid 212 Interferon 54 Inhibition alpha 2 recombinant purifn refolding electrophoresis electroblotting lab substrate biliverdin reductase chloride 58 expt 762 403 antigen class I gene transcription Fc receptor subtype monocyte 734 Inhibitor 605 isotype Fc receptor subtype binding human platelet aggregation barley carbon tetrachloride toxicity liver 725 19 632 monoclonal Rh antigen Fc receptor platelet aggregation liver cytosol 898 colon tumor growth inhibition 1049 733 Initiation gene expression Escherichia 48 monoclonal Rh antigen leukocyte codon interferon gene mutation Es• Interleukin rosette 727 cherichia 48 1 beta three dimension structure Fc region monoclonal antibody idio• factor eIF2 Saccharomyces 45 949 typy 747 Initiator 1 synovium arachidonate 286 IgG4 protein REP D DNA tyrosine 758 2 placenta protein 14 immunosup3 glycosylation heterogeneity 340 Injury pression 794 nerve actin substance P neuron 465 1136 KEYWORD INDEX

Interleukinl protein disulfide solubilization micro= thymidine leakage cell proliferation synovial cell antirheumatic drug 892 some 58 55 Internalization Isoprenaline tyrosine insulin receptor regulation adrenergic receptor adenylate cyclase heart respiration glycolysis calcium liver 40 desensitization 308 591 tyrosine protein affinity chromatog Interphotoreceptor Isotope liver 780 retinoid binding protein apolipopro^ stable ketone body turnover 736 Kinin tein E 318 Jaffe kallikrein system heart ischemia Intestine reaction creatinine detn 393 394 1011 brush border iron transport 832 395 Kirromycin contraction sodium calcium exchange reaction creatinine detn acetoacetate elongation factor EFTu interaction 589 549 761 liposome uptake glycolipid 342 reaction creatinine detn bilirubin Klebsiella pancreas enlargement diet soybean 550 551 pullulanase collagen like quaternary protein 610 Kallikrein structure 722 Intracellular kinin system heart ischemia 1011 pullulanase core structure function messenger polyamine thyroid 397 Keratan 723 pH insulin secretion 807 sulfate eye cornea distribution 333 Klenow Ion Keratin fragment DNA polvmerase replication affinity metal complex 835 epidermis calcium vitamin A 327 fidelity 947 exchange HPLC oligodeoxyribonu^ epidermis hydroxyvitamin D3 psoria= Kluyveromyces cleotide 368 sis 331 fermn control calorimetry 1091 inorg liver acetate 577 formation pilosebaceous duct acne Kupffer transport stomach mucosa thiocya= 330 cell carcinoembryonic antigen recep= nate methylphenylmethoxyimidaz^ Keratinocyte tor endocytosis 1027 opyridineacetonitrile 27 proliferation differentiation review Lab IR 666 expt IgG electrophoresis electroblot^ spectrometry brain oxygenation detn Ketoconazole ting 762 980 inhibition aromatase ovary placenta expt recombinant plasmid 763 spectrometry tissue oxygenation 978 29 Label Iron Ketoisocaproate photoaffinity monoamine oxidase binding ferritin light chain mutant pancreas GTP insulin 809 active site 214 838 Ketone Lactamase binding transferrin bicarbonate review body metab etomoxir 797 beta kinetics Enterobacter cefotaxime 825 body succinate thiokinase metabolic resistance 404 dextran liver subcellular processing role 795 beta structure kinetics review 934 854 body turnover detn 736 Lactate erythrocyte oxygen radical 292 Ketotifen dehydrogenase fibroblast dodecylimi^ heme protoporphyrin HPLC 831 arachidonate lipoxygenase inhibition dazole 43 hemosiderin ferritin liver hemochro= 814 dehydrogenase isoenzyme purifn matosis 830 Kidney heart liver 18 lipid peroxidn kidney brush border brush border calcium metab gentami^ formation heart isoprenaline calcium 20 ein 213 591 transferrin uptake hepatocyte ethanol brush border lipid peroxidn iron 20 Lactation 575 cortex membrane uridine transport cholesterol acyltransferase mammary transport hepatocyte transferrin 768 1013 endocytosis 618 failure uteroglobin like protein urine Golgi membrane mammary protein uptake carrier size brush border 832 970 phosphorylation 285 Ischemia rubidium transport detn NMR 596 mammary gland enzyme EGF 778 calcium glutamate synaptosome 880 rubidium 87 NMR lineshape analysis Lactobacillus cell membrane protein lipid 537 806 bioluminescence phosphate depen= heart kallikrein kinin system 1011 Tamm Horsfall glycoprotein review dence lux gene 1068 xanthine dehydrogenase oxidase 547 Lactoferrin tissue 358 toxicity chloroform polyriboinosinic casein bound milk 215 Iso polyribocy tidy lie acid 631 Lactoglobulin 1 cytochrome c structure arginine tubule resorption phosphate depletion milk allergenicity rat 338 844 785 Lactose Isocitrate tubule sodium phosphate cotransport diet copper deficiency immunity 54 dehydrogenase heart mitochondria 353 Laminin 873 Kinase axon retina ganglion cell regeneration dehydrogenase isoenzyme AMP hys= adenosine inhibitor cytotoxicity struct 440 teresis Acinetobacter 870 ture 756 Lattice dehydrogenase NAD Methylophilus creatine muscle hypoxia ultrastruc= contact protein crystn 961 871 ture calcium 1052 Laudanosine Isoelec creatinine epitope localization mono^ neuromuscular junction atracurium focusing gel blotting protein 154 clonal antibody 717 336 focusing wheat gluten alpha gliadin insulin receptor autophosphorylation Lecithin 748 site 1065 cholesterol acyltransferase secretion Isoenzyme insulin receptor zinc cadmium copper hepatocyte 155 ale aldehyde dehydrogenase review 896 Lectin 223 myosin light chain regulation review activity serine proteinase 1035 galactosyltransferase detection immu= 499 interaction Leishmania Trypanosoma noblotting 158 phosphoglycerate substrate binding 586 isocitrate dehydrogenase Acinetobac= site NMR 724 Leishmania ter AMP hysteresis 870 protein activation dense vesicle phos= lectin interaction 586 lactate dehydrogenase purifn heart phodiesterase 1025 lipophosphoglycan function review liver 18 protein C activator platelet secretion 259 UDP glucuronosyltransferase gene 804 Lens human liver 157 protein C glia TPA 294 nonenzymic glycated protein cataract Isomerase protein C hyperalgesia prostaglandin 648 protein disulfide bacteria 57 818 Leprosy protein disulfide lymphocyte matura= protein C nervous system review 460 antigen immunoblotting review 143 tion 56 protein C subspecies organ 307 Leucine protein disulfide mechanism function protein cAMP activity ratio detn aminopeptidase brain cortex human review 96 355 850 KEYWORD INDEX 1137

aminopeptidase inhibition leucine Liposome fatty acid synthase ethanol 580 thioamide 185 ATPase structure function 914 fructose bisphosphate substrate aminopeptidase inhibition methylleu3 Bacillus endotoxin interaction 39 1015 cine chloromethyl ketone 186 cryoprotectant 354 gluconeogenesis propionate sheep Leuconostoc drug carrier review 917 phosphoenolpyruvate carboxyki3 glucose phosphate dehydrogenase insulin oral distribution 343 nase 204 hexokinase detn 867 lithium transport NMR 207 glyceride ethanol dependence review Leukemia malaria sporozoite vaccine review 251 cell calcium SRI 62 834 278 921 glycogen formation gluconeogenic cell monoclonal antibody 376 membrane model therapeutic applica3 precursor 579 fucosyltransferase blood cell chemo3 tion 909 high mol wt nonlysosomal proteinase therapy substrate 1034 model membrane lipid diversity review 629 Leukocyte 912 human UDP glucuronosyltransferase arachidonate metab corticosteroid phosphatidylcholine phase transition isoenzyme gene 157 279 348 hydroxymethylglutarylCoA synthase Fc receptor function lipocortin 1 730 prepn property drug delivery review glucagon mannoheptulose 633 oxygen radical formation penicilla3 910 inorg ion acetate 577 mine 891 protein brain reconstitution extrusion insulin degrdn endosome 574 Rh antigen rosette monoclonal IgG 352 insulin endocytosis ethanol 573 727 sodium efflux alamethicin hemolysin insulin processing fasting 1041 Leukotriene melittin 594 insulin receptor chloroquine 1040 cardiovascular system review 482 uptake intestine glycolipid 342 insulin receptor tyrosine kinase regu3 heart vasoconstriction 361 Lipoxygenase lation 40 LHRH arachidonate inhibition ketotifen iron dextran subcellular processing calcium protein kinase C 597 814 854 gonadotropin pituitary androgen 170 fatty acid substrate inhibition 38 iron hemosiderin ferritin hemochro3 Ligand Lipoyl matosis 830 mol recognition dihydrofolate reduc3 group pyruvate dehydrogenase desen3 lactate dehydrogenase isoenzyme tase mutation 925 sitization ethylmaleimide 775 purifn 18 protein mol recognition review 927 Liq lecithin cholesterol acyltransferase receptor interaction protein blotting chromatog acyl carnitine 796 secretion 155 138 chromatog fast protein DNA 368 linoleate desaturase PCB species Lignin chromatog iron heme protoporphyrin 1072 Capsicum culture capsaicin prodn 831 lipogenic enzyme hormone 33 66 chromatog thromboplastin apoprotein lithium transport 208 peroxidase Phanerochaete 369 570 malic enzyme genetic diabetes 31 Linoleate Literature metab angiotensin 636 desaturase liver PCB species 1072 retrieval vol education 379 microsome hydroxy steroid dehydro3 Lipase Lithium genäse bird 22 Chromobacter adsorption heptane NMR biochem dysprosium shift microsome inositol trisphosphate water interface 273 reagent 207 tetrakisphosphate 593 diacylglycerol brain 293 osteoclast long bone development mitochondria protein affinity chroma3 esterase growth Aspergillus 790 newborn 826 tog 602 hormone sensitive heart 1038 transport erythrocyte 205 mixed function oxidase 801 Lipid transport erythrocyte NMR 827 monooxygenase polyriboinosinic algae heavy metal 275 transport liver 208 polyribocytidylic acid 630 aorta media distribution senescence Liver oncogene expression DMN 1058 164 acetaldehyde toxicity review 241 phenylalanine hydroxylase mRNA cell membrane ischemia 537 acinus fatty acid glucagon 1007 diabetes 1057 diversity membrane liposome model alanine glyoxylate aminotransferase phenylalanine hydroxylation EGF review 912 hyperoxaluria 1 627 insulin 897 inositol hydrolysis hippocampus aminolevulinate synthase antidepres3 polyunsatd fatty acid oxidn review carbamazepine anticonvulsant sant 847 420 986 atracurium toxicity 614 protein isoelec focusing blotting 154 manuf yeast review 1088 bass glucose phosphate dehydrogenase pyruvate dehydrogenase fatty acid membrane ATPase self assocn 346 inactivation 903 553 NMR spectrometry 1 bile acid low density lipoprotein 566 pyruvate dehydrogenase starvation peroxidn iron kidney brush border calcium sensitive dehydrogenase refeeding 773 20 barium mitochondria 590 pyruvate metab dexamethasone Lipocortin carbon tetrachloride toxicity interfer3 1075 protein p68 sequence 813 on 632 quinone redox cycle pyridine nucleo3 1 leukocyte Fc receptor function 730 carnitine metab insulin starvation tide 866 Lipogenesis 1014 recombinant ferritin light chain mu3 carbonic anhydrase grasshopper 973 carnitine palmitoyltransferase I etha3 tant 838 fetus brown adipocyte culture 274 nol 649 region glutamine synthetase expres3 insulin genetics fatness 1037 carnitine palmitoyltransferase mito3 sion 572 Lipogenic chondria membrane diabetes tyrosine protein kinase affinity chro3 enzyme liver hormone 33 1010 matog 780 Lipophosphoglycan cCMP phosphodiesterase effector UDP glucuronosyltransferase hypo3 function Leishmania review 259 sensitivity 774 thyroidism substrate 802 Lipopolysaccharide cytochrome P 450 642 Locust arsenazo III cation binding 716 cytosol aldehyde dehydrogenase ki3 acetylcholine receptor gene cloning Lipoprotein netics mechanism 856 857 '463 apolipoprotein E rich receptor platel3 cytosol platelet aggregation inhibitor Long et 154 898 chain alkylamine phospholipase A2 blood hypercholesterolemia diabetes dehydrogenase development 899 inhibition 816 atherosclerosis rabbit 200 endoplasmic reticulum partition Low low density bile acid liver 566 centrifugation 34 density lipoprotein lymphocyte mito3 low density lymphocyte mitogenesis enzyme hyperoxaluria 2 626 genesis 202 202 ethanol metab ale dehydrogenase density lipoprotein platelet calcium low density platelet calcium 287 239 287 receptor detn HepG2 cell 363 fatty acid binding protein purifn density lipoprotein receptor detn receptor fibroblast vein cAMP 1008 719 363 serum cell adhesion atherosclerosis fatty acid metab hormone 1002 Luliberinase 560 fatty acid metab sheep 203 brain cytosol microsome 209 1138 KEYWORD INDEX

Lung rus 1019 ase 321 adrenergic receptor desensitization cholesterol acyltransferase pregnancy vesicle sialoglycoprotein release tryp• 569 lactation 1013 sin tumor 189 metab apolipoprotein surfactant 276 epithelium rat p9Ka gene mRNA Mercurial parenchyma contraction inositol 1061 hydrogenase inactivation Desulfovi^ phosphate 35 gland enzyme lactation EGF 778 brio 178 Lux lactation Golgi membrane protein Mercuric gene Vibrio cloning Lactobacillus phosphorylation 285 reductase essential cysteine site mu2 Streptococcus 1068 neoplasm estrogen RNA ICI 164384 tation 90 Lyase 1063 Messenger phenylalanine ammonia calcium Mandelate metab control phosphoinositide review phytoalexin 1069 dehydrogenase Rhodotorula 865 657 Lyme Manganese Metab disease diagnosis antibody Borrelia oxide complex dinuclear model cata- control messenger phosphoinositide protein 161 läse 822 review 657 Lymphoblast Mannoheptulose Metabolic iron transport transferrin endocytosis hydroxymethylglutarylCoA synthase pathway evolution Acinetobacter 618 liver 633 153 Lymphocyte Mannose Metal activation assocd antigen protein VSG glycolipid formation Trypanoso• chelator computer modeling 835 383 ma 996 heavy insulin receptor protein kinase activation serine metab 622 Mapping 896 helper T DNA autoantibody 148 cloning DNA Chlorella 759 heavy lipid algae 275 IgG Fc receptor Rh antigen 733 peptide antigen mitochondria 151 ion carboxylate complex deprotona= maturation protein disulfide isomer^ restriction cloning casein gene mouse tion 406 ase 56 624 Metalloendopeptidase mitogenesis cholesterol low density restriction expression casein gene neurotensin degrdn brain 851 lipoprotein 202 rabbit 623 Metallopeptidase T stimulation dipeptidyl aminopepti= sequence human genome 766 enkephalin degrading cerebral cortex dase IV 365 Mass 405 Lymphokine spectrometry peptide nitrosation Metalloproteinase gene expression human RNase 367 detn 740 myelin demyelinating disease 469 synovial cell glycolysis 889 spectroscopy electron capture steroid Metallothionein Lysine detn 737 I inflammation 820 essential glutamate dehydrogenase Maturation Methylaminoethyl Escherichia 874 lymphocyte protein disulfide isomer^ acetate neurovegetative transmitter glycated urine 29 ase 56 adrenal 565 NADP glutamate dehydrogenase Meat Methylase Escherichia 876 collagen elastin cooking 169 DNA pea 757 substrate site glutamate dehydroge= Media DNA type I evolution review 942 nase Clostridium 875 aorta lipid distribution senescence Methylaspartate Lysosome 164 glutamate receptor solubilization dipeptide uptake mechanism 42 Medicarpin 314 fluorescence disease diagnosis review elicitation alfalfa calcium 1069 receptor thienylcyclohexylpiperidine 11 Melittin brain 300 sarcoplasmic reticulum muscle 786 sodium efflux liposome 594 Methylglyoxal Lysosomotropic Membrane guanylhydrazone cell uptake 210 agent muscle 786 anchor glycosylphosphatidylinositol Methylleucine Macaca Trypanosoma review 265 chloromethyl ketone inhibition leu• pregnenolone metab testis 1003 brush border protein proteoliposome cine aminopeptidase 186 testis steroidogenesis oxytocin 1004 344 Methylophilus Macaque cell ischemia protein lipid 537 NAD isocitrate dehydrogenase 871 pregnenolone metab testis 1003 dihydrolipoamide dehydrogenase Methylphenylmethoxyimidazopyridinea^ testis steroidogenesis oxytocin 1004 transport function review 87 cetonitrile Macrophage enzyme phosphoatidylinositol anchor inhibition ATPase stomach 27 alveolar collagenase 391 detergent solubilization 583 Methylprostaglandin fibrinopeptide endocytosis fibronectin erythrocyte potassium transport E2 paracetamol toxicity hepatocyte 559 calcium neomycin 598 641 Major fusion osmotic force 882 Methyltransferase histocompatibility complex detn 769 glutamate binding protein 446 DNA structure mammal 944 Malantide glycolipid anchor VSG protein 996 Methylxanthine cAMP protein kinase activity ratio Golgi protein phosphorylation mam= inhibition microsome activation ami= 355 mary lactation 285 noimidazoarene mutagen 620 Malaria interface calcium carbonate crystn Mevinolin sporozoite vaccine liposome review 824 lymphocyte mitogenesis cholesterol 921 lipid ATPase self assocn 346 202 Malic lipid diversity liposome model review Microbiol enzyme genetic diabetes 31 912 education Beneckea 767 enzyme hormone liver 33 lysosome dipeptide translocation Micrococcal Malignant mechanism 42 nuclease active inactive gene nucleo^ effusion galactosyltransferase isoen= model therapeutic application lipo= some 1060 zyme detection 158 some 909 Microsome Maltase NMR spectrometry 1 activation aminoimidazoarene muta= Streptomyces alpha glucosidase sepn permeability fenpropimorph fungici = gen inhibition methylxanthine specificity 180 dal activity 350 620 Mammal permeability squalene Saccharomyces brain luliberinase 209 calcium mitochondria function review naftifine 1044 fluidity fatty acid pyrene 349 523 phospholipid ATPase oleate 347 inositol trisphosphate tetrakisphosp^ cyclic nucleotide phosphohydrolase prepn sarcoplasmic reticulum sarco^ hate liver 593 sequence homol 304 lemma 356 liver hydroxy steroid dehydrogenase DNA methyltransferase structure protein detn Bradford detergent 382 bird 22 944 protein gene chloroplast review 704 Mytilus oxygen radical benzopyrene Hb sequence evolution 608 synapse peptidase neurotensin degrdn metab 779 Mammary 851 partition dextran PEG phase 34 cell transformation oncogene retrovi= synaptic bound glutamate decarboxyl^ polyunsatd fatty acid oxidn review KEYWORD INDEX 1139

420 antibody ATPase sarcoplasmic reticu3 uremia 578 protein disulfide isomerase solubiliza• lum 771 glycogen hyperthyroidism starvation tion 58 antibody brain tumor cell 373 refeeding rat 554 Microvessel antibody cerbB2 oncogene protein heart protein formation ethanol 783 glucose transporting protein liposome 675 hypoxia creatine kinase ultrastructure 352 antibody creatinine kinase epitope calcium 1052 Midgut localization 717 ileum contraction sodium animal gland Procambarus glutathione cad• antibody desmin intermediate fila• species 588 mium 23 ment 52 insulin sensitivity glucocorticoid 174 Milk antibody idiotypy IgGl Fc region lysosomotropic agent 786 casein bound lactoferrin 215 747 myosin phosphorylation regulation galactosyltransferase isoenzyme de• antibody leukemia cell 376 contraction review 499 tection 158 IgG Rh antigen Fc receptor 733 protein ethanol 571 lactoglobulin allergenicity rat 338 IgG Rh antigen leukocyte rosette relaxant adductor pollicis muscle protein electrophoresis 165 727 fatigue 336 Mineralization Monocyte sarcolemma acetylcholinesterase stereochem stearate interface crystn antitrypsin mRNA tumor necrosis immunocytochem localization 770 824 factor 1055 sarcoplasmic reticulum 380 Mitochondria Chemotaxis inhibition antibody differ• skeletal oxygen paradox 1050 antigen peptide mapping immunob• entiation antigen 966 smooth blood vessel proteoglycan lotting 151 complement Clq receptor purifn heparin 17 brown adipose biochem cold obesity 735 smooth calcium channel review 492 1009 IgG Fc receptor Rh antigen 733 smooth myosin phosphorylation fila= calcium sensitive dehydrogenase IgG Fc receptor subtype 734 ment assembly 501 barium 590 tumor killing reactive oxygen species smooth thin filament calcium review dicarboxylate metab 423 902 494 fatty acid oxidn defect review 424 Monooxygenase smooth thin filament regulation 355 function calcium review 523 liver polyriboinosinic polyribocytidylic smooth vein lipoprotein receptor heart protein antigen immunoelec- acid 630 cAMP 1008 troblotting 53 model binuclear copper complex 821 vascular cardiac regulation 503 isocitrate dehydrogenase heart 873 Monophosphoglycerate vascular relaxation cGMP 497 liver protein affinity chromatog 602 mutase Neurospora 558 Mussel membrane carnitine palmitoyltransf• Morphine benzopyrene metab microsome oxygen erase liver diabetes 1010 cholecystokinin brain periaqueductal radical 779 phosphate transporter Saccharomyces grey 538 Mustela 776 Mouse Hb beta chain sequence 608 protein targeting signal 709 casein gene sequence 1064 Mutagen protein transport review 701 cloning restriction mapping casein aminoimidazoarene microsome activa= Mitogen gene 624 tion inhibition methylxanthine prostate growth regulation 389 mycoplasma elimination infected 620 Mixed hybridoma 398 Mutant function oxidase HEP G2 hepatoma MPTP recombinant ferritin light chain liver 801 analog amine oxidase plasma 335 838 Model mRNA Mutase aldolase phosphocellulose interaction antitrypsin monocyte tumor necrosis monophosphoglycerate Neurospora 543 factor 1055 558 calcium heparin interaction 1028 deaminase porphobilinogen acute Mutation catalase dinuclear manganese oxide intermittent porphyria 799 dihydrofolate reductase mol recogni= complex 822 enkephalin brain 313 tion ligand 925 mol recognition review 923 estrogen cDNA human breast cancer site essential cysteine mercuric reduc= monooxygenase binuclear copper 169 tase 90 complex 821 parvalbumin brain localization 313 Mycobacterium simulation mol biol education 765 phenylalanine hydroxylase liver dia= stress protein immunity 721 Modulator betes 1057 Mycoplasma phosphoprotein phosphatase antibody p9Ka gene rat mammary epithelium elimination infected hybridoma mouse 720 1061 398 Mohair retina oocyte photosensitivity Xeno- Myelin detn wool fiber mixt 639 pus 299 basic protein oligodendrocyte differ• Mol Mucin entiation 900 biol education computer 764 gastric subunit size 585 metalloproteinase demyelinating biol education model simulation 765 structure stomach 584 disease 469 cloning eukaryote protein Escherichia Mucosa protein immunochem central nervous review 108 stomach ion transport thiocyanate system 614 recognition ligand dihydrofolate methylphenylmethoxyimidazopyri- Myelocyte reductase mutation 925 dineacetonitrile 27 inositol phosphatase 557 recognition model review 923 Mucus Myoinositol recognition oligosaccharide review glycoprotein colon adenoma carcino• diphosphate phosphorothioate 992 930 ma 581 Myopathy recognition protein ligand review Multicatalytic ethanol antioxidant plasma 581 927 high mol wt protease brain 852 Myosin Mollusk proteinase complex liver 629 light chain kinase regulation review inositol metab nerve 316 Muscle 499 Monitoring adductor pollicis fatigue atracurium phosphorylation filament self assem3 assessment research student project 336 bly regulation 501 118 bone circulation ethanol 576 Myristate Monkey calcium receptor review 520 VSG glycolipid formation Trypanoso• chicken estrogen receptor gene clon• collagen growth hormone 177 ma 996 ing 388 contraction regulation caldesmon Mytilus Monoamine 360 microsome oxygen radical benzopyr• oxidase active site photoaffinity label ethanol toxicity review 250 ene metab 779 214 gastrocnemius conduction block frog NAD Monoclonal 1020 cofactor analog dehydrogenase bind• antibody actin 163 glucocorticoid adrenergic agonist ing 862 antibody ATPase inhibition sarco= 1073 isocitrate dehydrogenase Methylophi3 plasmic reticulum 967 glycogen glucose phosphate cycling lus 871 1140 KEYWORD INDEX

metab ADP ribosylation inhibitor Neurochem Nitrovasodilator 869 detn brain postmortem 472 cGMP review 490 metab calmodulin tegument tapeworm periodical 599 NMR 868 Neurodegenerative alanine racemase vinylglycine phos- NADP glucose dehydrogenase Ther= disease postmortem brain analysis phonate analog 606 moplasma 864 472 anion binding blood plasma 714 NADH Neurofilament cytochrome c b5 interaction 844 site glycerol dehydrogenase Bacillus 976 antigen Alzheimer disease antibody erythrocyte peptide transport detn NADP 855 635 glutamate dehydrogenase Escherichia Neuroglia lineshape analysis kidney rubidium lysine 876 cyclic nucleotide phosphodiesterase 87 806 glycerol dehydrogenase bicarbonate formation 212 lithium biochem dysprosium shift Aspergillus 976 Neuromuscular reagent 207 NAD glucose dehydrogenase Thermo= blockade atracurium glycopyrrolate lithium transport erythrocyte 827 plasma 864 atropine neostigmine 746 phosphoglycerate kinase substrate NADPH glucose phosphate dehydro^ junction laudanosine atracurium 336 binding site 724 genäse conformation 903 transmission diaphragm tubocurarine phosphorus 31 Hb inositol hexa= NADPH 747 phosphate 839 cytochrome reductase Escherichia 872 Neuron rubidium transport detn kidney 596 formation liver quinone 866 actin substance P nerve injury 465 spectrometry lipid membrane 1 NADP glucose phosphate dehydroge^ cholinergic antigen Alzheimer disease spectrometry peptide induced ion nase conformation 903 855 transport 594 oxidase flavoprotein inhibition diphe- cholinergic astrocyte trophic factor Nonenzymic nyleneiodonium 888 296 glycated protein blood lens cataract Naftifine human protein PGP95 enolase cDNA 648 Saccharomyces squalene membrane 454 Nonidet permeability 1044 Neuroparalysis P40 protein detn Bradford 382 NCAM botulin A chain 886 Nonlysosomal glycoprotein sequence human 457 Neuropeptidase high mol wt proteinase liver 629 Near drug release peptide prodrug 214 Nonmuscle IR spectrometry brain oxygenation Neuropeptide myosin phosphorylation filament 980 degrdn leucine aminopeptidase brain assembly 501 IR spectrometry tissue oxygenation 850 Noradrenaline 978 Neurospora cAMP occipital cortex 311 NEM2 monophosphoglycerate mutase 558 phenylalanine hydroxylation EGF cell receptor adrenergic purinergic Neurotensin liver 897 432 degrdn metalloendopeptidase brain nRNP Neomycin 851 antigen autoantibody detection im• Azotobacter fiavodoxin electrochem Neurotransmitter munoblotting 162 graphite electrode 959 amino acid function aspartate 315 NSD erythrocyte membrane potassium brain postmortem 472 1055 cell growth polyamine 211 transport calcium 598 brain synaptosome sepn centrifugation Nuclease Neoplasm 309 micrococcal active inactive gene nu- bladder diagnosis glucose phosphate calcium growth cone brain 444 cleosome 1060 dehydrogenase 555 Neurovegetative Nucleic mammary estrogen RNA ICI 164384 transmitter methylaminoethyl acetate acid sequence analysis education 1063 adrenal 565 764 Neoplastic Neutropenia Nucleoside transformation ras PGF2alpha inosi• autoimmune neutrophil FcR 732 diphosphatase detn calcium activation tol phosphate 990 Neutrophil Golgi 561 Neostigmine activation threshold calcium cytosol Nucleosome glycopyrrolate atropine neuromuscu^ 37 active inactive gene micrococcal nu= lar blockade atracurium 746 degranulation response development clease 1060 NEP2 128 Nucleotidase cell receptor adrenergic purinergic FcR autoimmune neutropenia 732 AMP adenosine vasodilation review 432 IgA receptor opsonization 731 479 Nerve inositol phosphate formation throm= placenta trophoblast 1042 ATPase transport diabetes mellitus bin 280 Nucleotide 878 Newborn purine blood vessel review 480 calcium receptor review 520 betaine urine 788 pyridine quinone redox cycle liver cell astrocyte development 295 filaggrin cell envelope skin 324 866 injury actin substance P neuron 465 lithium osteoclast long bone develops Nucleus inositol metab mollusk 316 ment 826 ubiquitin protein detection antibody optic injury axon regeneration laminin Nicotinamide 1059 440 ADP ribosylation inhibition 869 Nutrient protein PGP95iconformation review Nicotinic insulin secretion intracellular pH 323 acetylcholine receptor cDNA cloning 807 protein phosphorylation botulin A locust 463 pancreas insulin GTP 809 885 Nifedipine Obesity sciatic conduction block frog 1020 ethanol vas deferens 381 brown adipose mitochondria biochem terminal brain glutamate aspartate Nimodipine cold 1009 879 ethanol vas deferens 381 insulin lipogenesis genetics 1037 terminal cholinergic adenosine ATP Nitrate Occipital 442 reductase Rhodobacter periplasm cortex noradrenaline cAMP 311 Nervous 182 Oil system central myelin protein immu- Nitrendipine hydrogenated platelet aggregation nochem 614 ethanol vas deferens 381 collagen 291 system central protein kinase C 307 Nitric Oleate system protein kinase C review 460 oxide reductase Paracoccus review ATPase sarcoplasmic reticulum 347 system sympathetic cholesterol metab 187 platelet phosphoinositide metab 288 201 Nitroprusside Oligodendrocyte system tocopherol deficiency 466 calcium inositol phosphate artery differentiation culture cyclic nucleo= Neural 486 tide phosphohydrolase 900 proteinase demyelinating disease Nitrosation Oligodeoxyribonucleotide 469 peptide detn mass spectrometry 740 immobilization DNA hybridization KEYWORD INDEX 1141

216 Oxoacyl Pentagastrin ion exchange HPLC 368 acyl carrier protein reductase plant pepsin gastric juice 26 Oligonucleotide 392 Pepsin immobilization cellulose 367 Oxygen detn semiautomated 26 Oligosaccharide paradox skeletal muscle 1050 Peptidase dolichol linked brain Batten disease protonated intermediate monooxyge3 DD structure kinetics review 934 1031 nase model 821 phaseolin digestion 612 mol recognition review 930 radical formation leukocyte penicilla3 synapse membrane neurotensin Oncogene mine 891 degrdn 851 cerbB2 protein monoclonal antibody radical iron erythrocyte 292 Peptide 675 radical Mytilus microsome benzopyr- antigen mitochondria mapping immu3 expression liver DMN 1058 ene metab 779 noblotting 151 fos epithelium cell transformation reactive species tumor killing mono3 astrocyte receptor 429 1019 cyte 902 gold electrode cytochrome b5 electro3 transfection thyroid cell 197 Saccharomyces cytochrome P450 chem 958 Ontogeny 370 induced ion transport NMR spec3 reproductive tract epithelium repro3 uptake detn peroxide erythrocyte trometry 594 gramming 810 284 nitrosation detn mass spectrometry Oocyte Oxygenation 740 photosensitivity retina mRNA Xeno3 detn blood tissue spectrometry 978 prodrug neuropeptidase drug release pus 299 detn brain IR spectrometry 980 214 Opsonization OxyHb signal ovalbumin antibody 36 IgA receptor neutrophil 731 heme stability alkali 386 transport detn erythrocyte NMR Optic Oxytocin 635 nerve injury axon regeneration lami3 steroidogenesis testis macaque 1004 Periaqueductal nin 440 Pachysolen grey brain morphine cholecystokinin Oral recycle xylose fermn ethanol 198 538 liposome insulin distribution 343 Paecilomyces Periodical Organ extracellular beta galactoside 183 biochem neurochem 599 cytochrome oxidase IR spectrometry PAGE Peripheral 978 SDS protein wool 639 nervous tissue ATPase galactosemia cytochrome P 450 642 Palmitoyltransferase diabetes 306 protein kinase C subspecies 307 carnitine I liver ethanol 649 Periplasm Origin carnitine liver mitochondria mem3 Rhodobacter nitrate trimethylamine replication interaction initiator pro• brane diabetes 1010 oxide reductase 182 tein tyrosine 758 Pancreas Permeability Ornithine enlargement diet soybean protein membrane fenpropimorph fungicidal decarboxylase brain cholinergic den• 610 activity 350 ervation 467 glucagon secretion arginine 1017 membrane lipid diversity review 912 decarboxylase epidermis psoriasis insulin adrenergic antagonist 1005 membrane squalene Saccharomyces 329 insulin GTP nutrient 809 naftifine 1044 Osmolality Paracetamol Peroxidase potassium transport chondrocyte toxicity hepatocyte methylprostaglan3 cytochrome c graphite electrode ami3 637 din'E2 641 noglycoside 842 Osmotic Paracoccus cytochrome kinetics ale cold 846 force membrane fusion 882 nitric oxide reductase review 187 lignin Phanerochaete 369 Osteoclast Parasite Peroxide long bone development newborn mammal glycoconjugate review 257 erythrocyte oxygen uptake detn 284 lithium 826 Parasympathetic selective electrode cytochrome peroxi3 Osteoclastoma dimethylaminoethyl acetate adrenal dase aminoglycoside 842 acid collagenase 1064 565 Peroxidn tartrate resistant acid phosphatase Parenchyma lipid iron kidney brush border 20 895 lung contraction inositol phosphate Peroxisome Osteomyelitis 35 beta oxidn enzyme formation review Staphylococcus exotoxin enzyme Parenteral 410 1000 amino acid heart protein formation dicarboxylate metab 423 Ovalbumin 782 polyunsatd fatty acid oxidn review signal peptide antibody 36 Parietal 420 Ovary cell stomach cAMP histamine 808 Pertussis aromatase inhibition ketoconazole Parotid toxin acid secretion stomach 281 29 proline rich protein processing 798 PGE2 follicle fluid inhibin 212 Partition synovial cell interleukin 1 antirheu3 Ovotransferrin affinity protein computer simulation matic drug 892 interaction indium 833 542 PGF2alpha Oxidase endoplasmic reticulum liver 34 inositol phosphate ras neoplastic amine plasma MPTP analog 335 immunoaffinity erythrocyte 968 transformation 990 cvtochrome IR spectrometry organ Parvalbumin PH ' 978 mRNA brain localization 313 intracellular insulin secretion 807 mixed function HEP G2 hepatoma PCB Phage 801 linoleate desaturase liver species P22 tailspike maturation folding monoamine active site photoaffinity 1072 aggregation 105 label 214 Pea Phagocyte superoxide inhibition phagocyte di- DNA methylase 757 chemiluminescence assay modulating phenyleneiodonium 888 wheat chloroplast gene review 704 factor 289 xanthine tissue ischemia 358 PEG diphenyleneiodonium superoxide Oxidn dextran phase microsome partition oxidase inhibition 888 beta enzyme formation peroxisome 34 Phagocytosis review 410 Penicillamine rod outer segment glycosaminoglycan beta fatty acid intermediate review isomer leukocyte chemiluminescence 319 410 891 Phanerochaete beta fatty acid review 418 Penicillin glucosidase lignin peroxidase 369 enzymol 409 recognizing enzyme review 934 Phase fatty acid mitochondria defect review Penicillium dextran PEG microsome partition 424 amylolytic enzyme fermn 181 34 polyunsatd fatty acid mechanism transition phosphatidylcholine lipo3 review 420 some 348 1142 KEYWORD INDEX

Phaseolin Phosphoinositide Placenta digestion peptidase 612 astrocyte peptide receptor 429 aromatase inhibition ketoconazole PhD fibroblast growth factor hydrolysis 29 completion rate research student 987 immunosuppressive factor horse 793 supervision 117 metab control messenger review 657 protein 14 immunosuppression inters Phenacetin metab kidney brush border gentami^ leukin 2 794 aniline transacetylation blood 742 ein 213 trophoblast nucleotidase 1042 Phencyclidine metab platelet oleate 288 uterus alk phosphatase 848 analog potassium channel brain 200 Phospholipase Plant Phenetidine A2 inhibition long chain alkylamine cell culture product recovery review acetylation blood 1071 816 67 Phenobarbital VSG glycoprotein eukaryote review ext amino acid decarboxylase detn cytochrome P 450 induction 642 271 972 Phenoxybenzoate Phospholipid oxoacyl acyl carrier protein reductase metab fish 24 branched chain liposome phase tran^ 392 Phenylalanine sition 348 Plasma ammonia lyase calcium phytoalexin formation channelling endoplasmic acyl carnitine detn 796 1069 reticulum 1036 amine oxidase MPTP analog 335 Capsicum culture capsaicin prodn membrane ATPase oleate 347 antioxidant ethanol myopathy 581 66 Phosphonate antithrombin III Dublin 2 variant hydroxylase liver mRNA diabetes analog bisadenosyl tetraphosphate 374 1057 interaction enzyme 713 enzyme protein immunoblotting hydroxylation liver EGF insulin 897 substrate analog aspartate amino= review 140 Phenyldodecane transferase 611 fatty acid pyruvate dehydrogenase metab species 25 vinylglycine analog alanine racemase 553 Phenylephrine inhibition 606 insulin IGF1 tissue protein proteogly= artery contraction calcium 493 Phosphoprotein can 624 seminal vesicle contraction Clonidine phosphatase calmodulin dependent Plasmid potassium 1021 detn fluorometry 297 loss cell division 193 Phorbol phosphatase modulator antibody maintenance expression Bacillus 194 ester polyphosphoinositide phosphor 720 recombinant lab expt 763 diesterase 994 Phosphorus stability gene expression Bacillus ester protein kinase C glia 294 31 NMR Hb inositol hexaphosphate 192 histamine cAMP parietal cell 808 839 transfection thyrocyte immortalization Phosphatase Phosphorylase 197 acid tartrate resistant osteoclastoma glycogen brain hypoxia fish 621 Plastocyanin 895 Phosphorylation cytochrome c complex electrochem alk uterus pregnancy 848 ATP synthase bifurcation hysteresis 957 inositol myelocyte 557 645 Platelet phosphoprotein calmodulin depend^ myosin filament self assembly regular aggregation collagen fatty acid isomer ent detn fluorometry 297 tion 501 291 phosphoprotein modulator antibody myosin regulation contraction muscle aggregation factor anticholinergic 720 review 499 drug 815 Phosphate protein Golgi membrane mammary aggregation inhibitor liver cytosol activation carbonic anhydrase III lactation 285 898 853 protein nerve botulin A 885 apolipoprotein E rich lipoprotein compartmentation erythrocyte 781 protein platelet secretion 804 receptor 154 dependence bioluminescence Strepto= thylakoid protein ATP fluorescence calcium low density lipoprotein 287 coccus lux gene 1068 46 human aggregation inhibitor barley depletion kidney tubule resorption tyrosine beryllium 1047 19 785 Phosphoserine phosphoinositide metab oleate 288 metabolite skin 324 localization casein sequence 745 secretion protein kinase C activator sodium cotransport proximal tubule Photoaffinity 804 353 label monoamine oxidase active site Plimmer transporter mitochondria Saccharo^ 214 biog 601 myces 776 labeling ATPase potassium site stom= PMA Phosphatidylcholine ach 823 polyphosphoinositide phosphodiester• liposome phase transition 348 Photoreceptor ase animal cell 994 Phosphoatidylinositol biochem electrophysiol hereditary Poly anchor membrane enzyme detergent rod dysplasia 1074 ADP ribose formation inhibitor 869 solubilization 583 Photosensitivity Poiyamine Phosphocellulose oocyte retina mRNA Xenopus 299 cell NSD 1055 211 aldolase interaction model 543 Phys intracellular messenger thyroid 397 Phosphodiesterase science biochem education 515 Polyhydroxybutyrate cCMP effector sensitivity liver 774 science education biochem example polyhydroxyalkanoate formation cyclic nucleotide formation brain 508 enzyme Alcaligenes 1046 neuroglia 212 Phytoalexin Polymerase dense vesicle activation protein kinase calcium phenylalanine ammonia DNA Klenow fragment replication 1025 lyase 1069 fidelity 947 polyphosphoinositide animal cell sesquiterpene elicitor Solanaceae 71 Polyol PMA 994 Picrate pathway diabetes mellitus complica= Phosphoenolpyruvate alk creatinine glucose spectra 394 tion 363 carboxykinase hepatocyte gluconeo= alk glucose creatinine 395 Polyphosphoinositide genesis propionate sheep 204 alk glucose spectra 393 carbachol depolarization brain synap= Phosphogluconate Pigeon tosome 320 dehydrogenase interference hexoki• erythrocyte taurine transport stoi- ornithine decarboxylase brain choli= nase detn 867 chiometry 555 nergic denervation 467 Phosphoglycerate Pilosebaceous phosphodiesterase animal cell PMA kinase substrate binding site NMR duct keratin formation acne 330 994 724 Pisum Polyribocytidylic Phosphohydrolase DNA methylase 757 polyriboinosinic acid liver monoox= cyclic nucleotide oligodendrocyte Pituitary ygenase 630 differentiation culture 900 calcium LHRH protein kinase 597 polyriboinosinic acid tissue cyto= cyclic nucleotide sequence homol cell hormone receptor review 437 chrome P450 631 mammal 304 gland secretory vesicle purifn 51 gonadotropin LHRH androgen 170 KEYWORD INDEX 11

Polyriboinosinic Progesterone formation heart parenteral amino polyribocytidylic acid liver monoox3 EGF receptor breast cancer 173 acid 782 ygenase 630 receptor gene chicken 683 formation initiation factor eIF2 Sac3 polyribocytidylic acid tissue cyto• Project charomyces 45 chrome P450 631 research student monitoring assess3 G hormone receptor review 434 437 Polystyrene ment 118 G prolactin growth hormone 887 surface hydration cell adhesion 1029 Prolactin gel isoelec focusing blotting 154 Polyunsatd G protein 887 glutamate binding sepn brain 446 fatty acid blood platelet aggregation gene glucocorticoid response element hspl08 gene human 174 385 176 HSP90 interaction glucocorticoid fatty acid oxidn mechanism review growth hormone gene regulation rat receptor review 688 420 699 immunoblotting review 131 Porphobilinogen Proline import endoplasmic reticulum review deaminase dipyrromethane cofactor rich protein processing parotid 798 708 active site 963 transport chondrocyte sodium 894 inclusion body purifn bacteria 102 deaminase formation aminolevulinate Promyelocyte initiator REP D DNA tyrosine 758 requirement 962 iron transport transferrin endocytosis interphotoreceptor retinoid binding deaminase mRNA acute intermittent 618 apolipoprotein E 318 porphyria 799 Propionate kinase activation dense vesicle phos3 Porphyria gluconeogenesis hepatocyte sheep phodiesterase 1025 acute intermittent porphobilinogen phosphoenolpyruvate carboxyki3 kinase C activator platelet secretion mRNA deaminase 799 nase 204 804 hepatoerythropoietic biochem patho- Prostaglandin kinase C glia TPA 294 physiol 829 protein kinase C hyperalgesia 818 kinase C hyperalgesia prostaglandin Postgraduate synthase short chain fatty acid 398 818 education biomedical science New Prostanoid kinase C LHRH 597 Zealand 120 platelet calcium lipoprotein 287 kinase C nervous system review 460 education Europe 122 Prostate kinase C subspecies organ 307 education student view 125 binding protein gene androgen recep3 kinase cAMP activity ratio detn 355 student career opportunity 128 tor 695 kinase insulin receptor zinc 896 Potassium growth regulation mitogen 389 ligand mol recognition review 927 artery contraction calcium 493 TRH processing hypothalamus 784 liver platelet aggregation inhibitor channel brain phencyclidine analog Protease 898 200 high mol wt multicatalytic brain 852 lymphocyte activation assocd antigen channel regulation review 532 Protein 383 seminal vesicle contraction pheny3 adhesive blotting analysis 144 manuf yeast 1081 lephrine Clonidine 1021 ADP ribosylation botulin 883 membrane anchor structure detergent site ATPase photoaffinity labeling affinity partition computer simulation solubilization 583 stomach 823 542 membrane eukaryote glycosylphos3 transport chondrocyte osmolality antigen immunoelectroblotting mito3 phatidylinositol review 271 637 chondria heart 53 membrane gene review chloroplast transport erythrocyte membrane beer electrophoresis 167 704 calcium neomycin 598 blotting receptor ligand interaction milk electrophoresis 165 Potential 138 mitochondria antibody biliary cirrho3 oscillation salivary inositol phosphate body formation glyoxysome review sis 151 Calliphora 988 706 mitochondria liver affinity chromatog redox ferredoxin I Azotobacter 840 Borrelia antibody detection immu3 602 Poxvirus noblotting 161 muscle ethanol 571 EGF skin tumor review 671 brain reconstitution liposome extru3 myelin basic oligodendrocyte differen Pptn sion 352 tiation 900 apoprotein factor III 570 calcium binding p9Ka gene rat 1061 myelin immunochem central nervous Prealbumin calcium binding rod outer segment system 614 interaction Remazol Yellow GGL 299 NMR membrane 1 anion 603 calcium binding thin filament 355 nonenzymic glycated blood lens cata3 Precursor cell membrane ischemia 537 ract 648 cathepsin L activation 1056 cerbB2 oncogene monoclonal antibody PGP95 conformation nerve review Pregnancy 675 323 alk phosphatase uterus 848 chloroplast processing assembly review PGP95 enolase cDNA human neuron cholesterol acyltransferase mammary 703 454 1013 complex electrochem graphite elec3 phosphorylation Golgi membrane immunosuppression placenta factor trode 957 mammary lactation 285 horse 793 conformation gamma turn review 50 phosphorylation nerve botulin A 885 Pregnenolone crystn lattice contact 961 phosphorylation thylakoid ATP metab oxytocin testis macaque 1004 detn Bradford membrane detergent fluorescence 46 metab testis macaque 1003 382 placenta 14 immunosuppression inter3 Presequence detn turbidimetry detergent TCA leukin 2 794 ATP synthase mitochondrial targeting 640 plasma anion binding NMR 714 709 disulfide isomerase bacteria 57 plasma immunoblotting review 140 Presynaptic disulfide isomerase lymphocyte matu3 proline rich processing parotid 798 regulation glutamate release brain ration 56 proteoliposome sodium alanine trans3 881 disulfide isomerase mechanism func3 porter 344 Primary tion review 96 p68 sequence lipocortin 813 biliary cirrhosis antigen mitochondria disulfide isomerase solubilization recombinant secretion yeast review 53 microsome 58 1083 Proacrosin engineering purifn affinity chromatog sequence analysis computer education sperm carbohydrate binding 1035 111 764 Procambarus estradiol binding Candida 789 soybean diet intestine pancreas en3 midgut gland glutathione cadmium eukaryote expression solubilization largement 610 23 refolding Escherichia 108 staining antigen immunoblotting Prochymosin fatty acid binding purifn liver 719 single gel 149 denaturation reversibility purifn 59 fibroblast extracellular antiserum Staphylococcus endocarditis antibody recombinant purifn Escherichia 112 375 997 Prodrug FNR DNA binding specificity Escher3 stress Mycobacterium immunity 721 peptide neuropeptidase drug release ichia 755 targeting signal mitochondria 709 214 formation heart muscle ethanol 783 tissue plasma insulin IGF1 624 1144 KEYWORD INDEX

transport mitochondria review 701 tion 772 388 tyrosine kinase affinity chromatog dehydrogenase lipoyl group desensiti^ estrogen gene human 388 liver 780 zation ethylmaleimide 775 Fc function leukocyte lipocortin 1 ubiquitin detection antibody nucleus dehydrogenase liver starvation refeed= 730 1059 ing 773 Fc monoclonal IgG Rh antigen 733 uncoupling mitochondria cold obesity dehydrogenase Saccharomyces 776 Fc subtype IgG isotype binding 725 1009 metab dexamethasone liver 1075 GABA butylbicyclophosphorothionate VSG glycolipid anchor membrane Quaternary ganglion insect 475 996 structure collagen like pullulanase glucocorticoid heat shock protein Wolfgram formation brain neuroglia Klebsiella 722 review 688 212 Quinone glutamate solubilization methylaspar= wool SDS PAGE 639 redox cycle pyridine nucleotide liver täte quisqualate 314 Proteinase 866 hormone activation review 437 cysteine active form detection cell Quisqualate hormone G protein review 434 811 glutamate receptor solubilization IgA neutrophil opsonization 731 high mol wt nonlysosomal liver 629 314 IgG Fc subtype monocyte 734 neural demyelinating disease 469 Rabbit insulin autophosphorylation site serine lectin activity 1035 beta casein gene 623 1065 Proteoglycan ileum contraction sodium 588 insulin chloroquine liver 1040 blood vessel smooth muscle heparin lipoprotein blood hypercholesterole= insulin kinase zinc cadmium copper 17 mia diabetes atherosclerosis 200 896 detection enzyme Western blotting Racemase insulin tyrosine kinase regulation 159 alanine inhibition vinylglycine phos= liver 40 hyaluronate binding fragment carti= phonate analog 606 interleukin 2 placenta protein 14 läge 188 Radioligand 794 tissue plasma insulin IGF1 624 binding assay inositol phosphate 991 ligand interaction protein blotting Proteolipid Rainbow 138 protein myelin immunochem analysis trout phenyldodecane metab 25 lipoprotein detn HepG2 cell 363 614 Raman lipoprotein fibroblast vein cAMP Proteoliposome resonance glyceraldehyde phosphate 1008 protein sodium alanine transporter dehydrogenase 49 methylaspartate thienylcyclohexylpi= 344 Rape peridine brain 300 Proton oxoacyl acyl carrier protein reductase nicotinic acetylcholine cDNA cloning sodium exchange adrenal chromaffin 392 locust 463 granule 595 Ras peptide astrocyte 429 transport Aspergillus 969 neoplastic transformation PGF2alpha progesterone gene chicken 683 Protooncogene inositol phosphate 990 Recognition prostate growth hormone 389 Rat mol ligand dihydrofolate reductase Protoporphyrin androgen receptor prostate protein mutation 925 iron heme HPLC 831 gene 695 mol model review 923 Proximal calcium binding protein p9Ka gene mol oligosaccharide review 930 tubule sodium phosphate cotransport 1061 mol protein ligand review 927 353 diaphragm twitch tetanic fatigue Recombinant Psoriasis 382 ferritin light chain mutant liver 838 hydroxyvitamin D3 epidermis keratin glycogen muscle hyperthyroidism plasmid lab expt 763 331 starvation refeeding 554 protein secretion yeast review 1083 ornithine decarboxylase epidermis ileum contraction sodium 588 Recombination 329 prolactin growth hormone gene regu= genetic mechanism resolvase 754 Public lation 699 genetic resolvase DNA supercoiling sector viewpoint research 128 Reacetylation 760 Pullulanase deacetylation arylamide blood 743 type I restriction enzyme review 942 core structure function Klebsiella Reactive Redox 723 oxygen species tumor killing mono= mechanism thioredoxin glutaredoxin Klebsiella collagen like quaternary cyte 902 disulfide 95 structure 722 Reactor potential ferredoxin I Azotobacter Pulmonary enzyme biochem engineering educa• 840 artery sarcoplasmic reticulum sarco- tion 516 state liver angiotensin 636 lemma sepn 356 Receptor Reductase Pump adrenergic desensitization lung 569 biliverdin chloride substrate inhibition calcium phosphoprotein Golgi mam= adrenergic internalization adenylate 403 mary 285 cyclase desensitization 308 dienoyl CoA review 420 Purine androgen prostate binding protein dihydrofolate mutation mol recogni= nucleotide blood vessel review 480 gene 695 tion ligand 925 Purinergic androgen regulation fibroblast skin glutathione mechanism Escherichia receptor astrocyte cell 432 172 84 Putamen apolipoprotein E rich lipoprotein glutathione structure mechanism enkephalin mRNA 313 platelet 154 review 81 Pyrene astrocyte cell adrenergic purinergic glyoxylate liver hyperoxaluria 2 626 fatty acid fluidity microsome 349 432 GMP IMP dehydrogenase homol Pyridine atriopeptin heart sarcolemma 1022 Escherichia 858 nucleotide quinone redox cycle liver benzodiazepine ganglion grasshopper mercuric essential cysteine site muta= 866 310 tion 90 Pyridinoline binding myoinositol diphosphate NADPH cytochrome Escherichia urine rheumatoid arthritis 817 phosphorothioate 992 872 Pyridoxal calcium LHRH protein kinase 597 nitrate trimethylamine oxide Rhodo- phosphate blood platelet aggregation calcium muscle nerve review 520 bacter periplasm 182 385 carcinoembryonic antigen endocytosis nitric oxide Paracoccus review 187 phosphoadenine nucleotide glutamate Kupffercell 1027 oxoacyl acyl carrier protein plant dehydrogenase 861 complement Clq purifn monocyte 392 Pyrrolidinone ribonucleotide Bl sequence Escheric= . 735 gastrin peptide beta bend 175 dihydropyridine calcium channel hia 91 Pyruvate subunit deglycosylation 452 thioredoxin glutaredoxin redox mech= dehydrogenase fatty acid plasma dopamine D2 purifn brain 450 anism 95 553 EGF breast cancer hormone 173 Refeeding dehydrogenase heart aorta constrict estrogen gene cloning chicken monkey glucose starvation skin glycogen 332 KEYWORD INDEX 1145

starvation liver pyruvate dehydroge• 953 187 nase 773 benzoate metab metabolite 1021 NMR spectrometry lipid membrane Refolding calcium channel smooth muscle 492 1 eukaryote protein Escherichia 108 calcium homeostasis excitable cell oligosaccharide mol recognition 930 Regeneration 519 penicillin recognizing enzyme 934 axon retina ganglion cell laminin calcium mitochondria function 523 peroxisome beta oxidn enzyme forma• 440 calcium receptor muscle nerve 520 tion 410 Remazol catalase manganase oxide complex phosphoinositide metab control mes= Yellow GGL interaction prealbumin model 822 senger 657 anion 603 cGMP nitrovasodilator 490 phospholipase VSG glycoprotein Replication chloramphenicol acetyltransferase eukaryote 271 DNA virus SV40 545 active site 939 plasma enzyme protein immunoblot^ origin interaction initiator protein chloroplast gene transcription phot- ting 140 tyrosine 758 oregulation 711 polyunsatd fatty acid oxidn mecha= structure SV40 virus DNA 604 chloroplast membrane protein gene nism 420 Reproductive 704 potassium channel regulation 532 tract epithelium reprogramming gene chloroplast protein processing assem• product recovery plant cell culture expression 810 bly 703 67 Research collagen gene structure 661 protein body glyoxysome formation public sector viewpoint 128 collagen structure assembly skin 663 706 student project monitoring assess• congenital adrenal hyperplasia 691 protein conformation gamma turn ment 118 dihydrofolate reductase mol recogni• 50 student supervision PhD completion tion ligand 925 protein disulfide isomerase mechanism rate 117 dihydrolipoamide dehydrogenase function 96 Resolvase membrane transport function 87 protein immunoblotting 131 DNA mechanism substrate supercoil3 EGF peptide structure activity 671 protein import endoplasmic reticulum ing 760 eicosanoid skin disease 680 708 DNA mechanism transposon Tn3 endothelium derived relaxing factor protein kinase C nervous system 460 754 484 protein transport mitochondria 701 Resonance ethanol calcium channel 527 purine nucleotide blood vessel 480 Raman glyceraldehyde phosphate ethanol dependence glyceride liver recombinant protein secretion yeast dehydrogenase 49 251 1083 Resorption ethanol glucose metab 247 retinoid epidermis skin disease 668 kidney tubule phosphate depletion ethanol toxicity muscle 250 ribonucleotide reductase large subunit 785 ethanol tryptophan metab 254 Escherichia 91 Respiration ethanol xenobiotic metab microsome skin immunoregulation cytokine 677 heart isoprenaline calcium 591 232 small nuclear ribonucleoprotein 943 tumor cell gossypol uncoupler 616 fatty acid beta oxidn 418 sodium calcium exchange excitable Restriction fatty acid beta oxidn intermediate cell 529 enzyme type I evolution review 942 410 Tamm Horsfall glycoprotein kidney mapping cloning casein gene mouse gap junction channel function 534 547 624 genetic engineering brewing yeast terpene formation plant cell culture mapping expression casein gene rab• 1077 61 bit 623 glucocorticoid receptor heat shock thin filament calcium 494 Retina protein 688 thioredoxin glutaredoxin redox mech= apolipoprotein E antibody plasma glutathione reductase structure mech= anism property 95 318 anism 81 transferrin iron binding bicarbonate atrophy cGMP taurine Tibetan terri• glycoconjugate parasite mammal 257 825 er 317 glycosylphosphatidylinositol mem• Trypanosoma dolichol glycoprotein calcium binding protein 299 brane anchor Trypanosoma 265 formation 268 cyclic nucleotide phosphohydrolase Hansenula heterologous gene expres= type I restriction enzyme evolution sequence 304 sion 1081 942 ganglion cell axon regeneration lami• harmaline cardiovascular sodium variant surface glycoprotein formation nin 440 calcium exchange 539 Trypanosoma 261 mRNA oocyte photosensitivity Xeno- hormone receptor activation 437 yeast cytochrome P 450 genotoxicity pus 299 hormone receptor G protein 434 1086 pigment epithelium phagocytosis keratinocyte proliferation differentia• Rh glycosaminoglycan 319 tion 666 antigen monoclonal IgG Fc receptor Retinoid leprosy antigen immunoblotting 143 733 binding protein interphotoreceptor leukotriene cardiovascular system antigen monoclonal IgG leukocyte apolipoprotein E 318 482 rosette 727 epidermis skin disease review 668 lipid manuf yeast 1088 Rheumatoid Retrieval lipophosphoglycan function Leishma3 arthritis collagen hydroxypyridinium literature vol education 379 nia 259 crosslink urine 817 Retroposon liposome erythrocyte drug carrier synovial phospholipase A2 inhibition glyceraldehyde phosphate dehydroge• 917 alkylamine 816 nase gene Trypanosoma 1067 liposome malaria sporozoite vaccine Rhodobacter Retrovirus 921 periplasm nitrate trimethylamine oncogene mammary cell transforma• liposome model membrane lipid div= oxide reductase 182 tion 1019 ersity 912 Rhodotorula Reversed liposome prepn property drug delivery mandelate dehydrogenase 865 phase HPLC acyl carnitine 796 910 RIA Review lysosome fluorescence disease diagno• erythropoietin submaxillary gland acetaldehyde toxicity liver 241 sis 11 564 acyl CoA flavoprotein dehydrogenase mitochondria fatty acid oxidn defect Ribonucleoprotein 416 424 small nuclear review 943 adenosine vasodilation 479 mol cloning eukaryote protein Escher• Ribonucleotide ale aldehyde dehydrogenase isoen• ichia 108 reductase Bl sequence Escherichia zyme 223 mol recognition model 923 91 ale manuf 1079 mol recognition protein ligand 927 Ribosylation ale metabolizing enzyme genetics myosin light chain kinase regulation ADP inhibitor NAD metab 869 230 499 protein ADP botulin 883 aldehyde ale dehydrogenase human nerve protein PGP95 conformation RNA genetics 227 323 estrogen ICI 164384 mammary neo• antibody Fc region effector function nitric oxide reductase Paracoccus plasm 1063 1146 KEYWORD INDEX

RNase Seminal Small lymphokine gene expression human vesicle contraction phenylephrine nuclear ribonucleoprotein review 367 Clonidine potassium 1021 943 Ro vesicle epithelium reprogramming Smoke 15 1788 benzodiazepine receptor 810 tobacco fibronectin bronchoalveolar grasshopper 310 Senescence fluid 378 Rod collagen metab heart 749 Smooth dysplasia hereditary photoreceptor cytochrome f chloroplast Festuca muscle blood vessel proteoglycan biochem electrophysiol 1074 1054 heparin 17 outer segment calcium binding protein lipid aorta media distribution 164 muscle calcium channel review 492 299 Sepharose muscle myosin phosphorylation fila^ outer segment phagocytosis glycosam- chromatog antibody purifn immunob^ ment assembly 501 inoglycan 319 lotting 134 muscle thin filament calcium review Rubidium oligonucleotide immobilization 216 494 transport detn kidney NMR 596 Sequence muscle thin filament regulation 355 87 kidney NMR lineshape analysis analysis nucleic acid education 764 muscle vein lipoprotein receptor 806 cyclic nucleotide phosphohydrolase cAMP 1008 Saccharomyces homol mammal 304 Sodium allosuppressor gene SAL3 SAL4 30 Hb beta chain ferret 608 alanine transporter protein proteoli^ citrate synthase cDNA cloning 718 mapping human genome 766 posome 344 cytochrome P450 oxygen 370 mouse casein gene 1064 calcium exchange cardiovascular naftifine squalene membrane permea• NCAM glycoprotein human 457 harmaline review 539 bility 1044 protein PGP95 human 454 calcium exchange excitable cell review protein formation initiation factor protein p68 lipocortin 813 529 eIF2 45 pullulanase Klebsiella 722 723 calcium exchange intestine contraction pyruvate dehydrogenase mitochondria Serine 589 phosphate transporter 776 carbon 13 enzymic prepn 179 efflux liposome alamethicin hemolysin Salivary metab lymphocyte activation 622 melittin 594 gland acetylcholine acidosis calcium proteinase lectin activity 1035 hydroxytryptamine synaptosome 993 Serotonin calcium 803 potential oscillation inositol phos= secretion platelet protein phosphory= ileum muscle contraction animal phate Calliphora 988 lation 804 species 588 proline rich protein processing 798 synaptosome sodium calcium 803 phosphate cotransport proximal tu= Salmo Serpentine bule 353 phenyldodecane metab 25 Catharanthus cell culture 65 proline transport chondrocyte 894 Salmon Serum proton exchange adrenal chromaffin Aeromonas exoprotein antibody 999 cell adhesion lipoprotein atherosclero^ granule 595 Sarcoidosis sis 560 uridine transport kidney brush border collagenase elastase bronchoalveolar cholesterol copper deficiency lactose 768 fluid 390 diet 54 Solanaceae Sarcolemma Sesquiterpene sesquiterpene phytoalexin elicitor 71 heart atriopeptin receptor 1022 phytoalexin elicitor Solanaceae 71 Solubilization muscle acetylcholinesterase immuno- Sheep glutamate binding protein 446 cytochem localization 770 gluconeogenesis propionate hepato= glutamate receptor methylaspartate sarcoplasmic reticulum membrane cyte phosphoenolpyruvate carbox= quisqualate 314 prepn 356 ykinase 204 protein mitochondria SDS 53 Sarcoplasmic hepatocyte fatty acid metab 203 Soly reticulum ATPase inhibition mono• Shift substrate lipoxygenase product inacti— clonal antibody 967 reagent dysprosium lithium NMR vation 38 reticulum ATPase monoclonal anti= biochem 207 Somatomammotropin body 771 Short gene glucocorticoid response element reticulum ATPase oleate 347 chain fatty acid prostaglandin syn^ 176 reticulum calsequestrin muscle 380 thase 398 Somatostatin reticulum muscle lysosome 786 Sialoglycoprotein somatotropin secretion G protein reticulum sarcolemma membrane release membrane vesicle tumor tryp= 887 prepn 356 sin 189 Somatotropin Schistocerca Siderosome fatty acid metab liver 1002 lipogenesis carbonic anhydrase 973 iron dextran processing liver 854 prolactin gene regulation rat 699 Schistosoma Signal secretion G protein somatostatin carbohydrate antigen immunity 264 peptide ovalbumin antibody 36 887 Sciatic targeting protein mitochondria 709 Sorbitol nerve conduction block frog 1020 Silver dehydrogenase erythrocyte diabetes Science staining wool electrophoresis 639 mellitus 363 phys biochem education 515 Simian Southern phys education biochem example virus 40 chromosome sepn 546 blotting DNA detection probe 139 508 virus 40 DNA replication 545 Soybean SDS Simulation protein diet intestine pancreas en• PAGE protein wool 639 computer mol biol education 764 largement 610 solubilization protein mitochondria mol biol education 765 Species 53 Skin PCB linoleate desaturase liver 1072 Second cell envelope filaggrin newborn 324 Spectra messenger hormone receptor review collagen structure assembly review creatinine glucose alk picrate 394 437 663 glucose alk picrate 393 Secretion disease retinoid review 668 Spectrometry bicarbonate stomach thiocyanate eicosanoid review 680 IR brain oxygenation detn 980 methylphenylmethoxyimidazopyri^ fibroblast androgen receptor regular mass peptide nitrosation detn 740 dineacetonitrile 27 tion 172 NMR lipid membrane 1 Secretory glycogen glucose refeeding starvation NMR peptide induced ion transport protein protein disulfide isomerase 332 594 review 96 immunoregulation cytokine review oxygenation detn blood tissue 978 vesicle purifn sucrose centrifugation 677 Spectrophotometry 51 phosphate metabolite 324 bilirubin alk soln 550 Semiautomated tumor poxvirus EG F review 671 creatinine detn 549 551 pepsin detn 26 Sm protein detn detergent 382 antigen autoantibody detection im= munoblotting 162 KEYWORD INDEX 1147

Spectroscopy analysis protein immunoblotting Synovium atomic absorption lithium transport review 140 arachidonate interleukin 1 286 erythrocyte 827 lipid membrane NMR 1 Synthase mass electron capture steroid detn three dimension interleukin 1 beta aminolevulinate liver antidepressant 737 949 847 Sperm Student ATP phosphorylation bifurcation acrosome hyaluronidase staining 643 postgraduate career opportunity 128 hysteresis 645 proacrosin carbohydrate binding research project monitoring assess3 ATP presequence mitochondrial 1035 ment 118 targeting 709 Spleen research supervision PhD completion citrate cDNA yeast cloning Escheric3 cholesterol reverse transport 282 rate 117 hia 718 prostaglandin synthase inhibition view postgraduate education 125 fatty acid component plant 392 398 Submaxillary fatty acid liver ethanol 580 Sporozoite gland erythropoietin RIA 564 hydroxymethylglutarylCoA glucagon malaria vaccine liposome review 921 Substance mannoheptulose liver 633 Squalene P actin neuron nerve injury 465 prostaglandin short chain fatty acid membrane permeability Saccharo3 Substrate 398 myces naftifine 1044 inhibition biliverdin reductase chlo3 uroporphyrinogen III Escherichia SRI ride 403 965 62 834 calcium leukemia cell 278 Subunit Synthetase Stable alpha2 calcium channel carbohydrate glutamine expression liver region isotope ketone body turnover 736 452 572 Staining gastric mucin size 585 He toxin Helminthosporium 401 antigen protein immunoblotting single high mol wt proteinase liver 629 Helminthosporium aminoepoxyoxode3 gel 149 Succinate canoate formation 402 hyaluronidase sperm acrosome 643 thiokinase metabolic role 795 T wool silver electrophoresis 639 Sucrose lymphocyte helper DNA autoantibody Staphylococcus centrifugation secretory vesicle purifn 148 exotoxin enzyme osteomyelitis 1000 51 lymphocyte stimulation dipeptidyl protein endocarditis antibody 997 Sulfamethazine aminopeptidase IV 365 Starvation acetylation blood erythrocyte health Tailspike glucose refeeding liver glycogen 579 diabetes 786 maturation folding aggregation phage glucose refeeding skin glycogen 332 Sulfur P22 105 insulin carnitine metab liver 1014 amino acid aspartate uptake brain Tamm insulin processing liver 1041 302 Horsfall glycoprotein kidney review pyruvate dehydrogenase fatty acid Supercoiling 547 553 DNA transposon Tn21 resolvase Tapeworm refeeding glycogen muscle hyperthy3 mechanism 760 NAD metab tegument calmodulin roidism rat 554 Superoxide 868 refeeding liver pyruvate dehydroge3 dismutation heparin 1030 Targeting nase 773 oxidase inhibition phagocyte dipheny3 signal protein mitochondria 709 Stearate leneiodonium 888 Tartrate interface crystn mineralization stereo3 Supervision resistant acid phosphatase osteoclas3 chem 824 research student PhD completion toma 895 platelet phosphoinositide metab 288 rate 117 Taurine Stereochem Surface retina atrophy Tibetan terrier 317 mineralization stearate interface polystyrene hydration cell adhesion transport stoichiometry erythrocyte crystn 824 1029 pigeon 555 Steroid Surfactant TCA dehydrogenase hydroxy liver micro3 apolipoprotein lung metab 276 protein detn turbidimetry 640 some bird 22 SV40 Tegument detn electron capture mass spectros3 virus DNA replication 545 NAD metab calmodulin tapeworm copy 737 virus DNA replication structure 604 868 uterus alk phosphatase 848 Sympathetic Terpene Steroidogenesis nervous system cholesterol metab formation plant cell culture review adrenal adrenaline angiotensin 983 201 61 testis oxytocin macaque 1004 Synapse Terrier Stoichiometry acetylcholine brain adenosine ATP Tibetan retina atrophy cGMP taurine taurine transport erythrocyte pigeon 442 317 555 membrane peptidase neurotensin Testis Stomach degrdn 851 pregnenolone metab macaque 1003 acid secretion indolepropionylleucyla3 Synaptic steroidogenesis oxytocin macaque spartylphenethylamide 628 membrane bound glutamate decar3 1004 acid secretion pertussis toxin 281 boxy läse 321 Testosterone ATPase inhibition thiocyanate Synaptosome metab liver development bird 22 methylphenylmethoxyimidazopyri3 angiotensin converting enzyme brain metab oxytocin testis macaque 1004 dineacetonitrile 27 191 metab testis macaque 1003 ATPase potassium site photoaffinity brain depolarization carbachol poly3 prostate growth 389 labeling 823 phosphoinositide 320 Tetanic mucin structure 584 brain sepn centrifugation neurotran3 twitch fatigue rat diaphragm 382 mucin subunit size 585 smitter 309 Tetraphosphatase parietal cell cAMP histamine 808 glutamate calcium brain 879 bisadenosyl interaction substrate Streptococcus glutamate calcium ischemia anoxia analog 713 bioluminescence phosphate depend hypoglycemia 880 Tetrazolium dence lux gene 1068 hydroxytryptamine sodium calcium salt aldolase detection electrophoresis Streptomyces 803 750 alpha glucosidase maltase sepn specify Synovial salt aldolase detn 753 icity 180 cell glycolysis lymphokine cytokine Theazolecarboxamide Stress 889 adenine dinucleotide dehydrogenase protein Mycobacterium immunity cell interleukin 1 antirheumatic drug binding 862 721 892 Therapeutic Structure fluid cathepsin B L arthritis 812 application membrane model lipo3 activity EGF peptide review 671 rheumatoid phospholipase A2 inhib3 some 909 adenosine kinase inhibitor cytotoxici3 ition alkylamine 816 Thermoplasma ty 756 glucose dehydrogenase 864 1148 KEYWORD INDEX

Thienylcyclohexylpiperidine Transcription Trophic methylaspartate receptor brain 300 chloroplast gene photoregulation factor astrocyte cholinergic neuron Thin review 711 296 filament calcium binding protein class I antigen gene transformation Trophoblast 355 605 nucleotidase 1042 filament calcium review 494 Transfection Trout Thioamide plasmid thyrocyte immortalization brown Aeromonas exoprotein anti= leucine inhibition leucine aminopepti^ 197 body 999 dase 185 Transferase Trypanosoma Thiobenzamide ADP ribose tegument tapeworm 868 dolichol glycoprotein formation review hepatotoxicity monooxygenase polyri= glutathione midgut gland Procamba^ 268 boinosinic polyribocytidylic acid rus cadmium 23 glycoprotein review 257 630 glutathione subunit brain 386 glycosylphosphatidylinositol mem^ Thiocyanate Transferrin brane anchor review 265 inhibition ATPase stomach 27 endocytosis iron transport hepatocyte lectin interaction 586 Thiokinase 618 retroposon glyceraldehyde phosphate succinate metabolic role 795 interaction indium 833 dehydrogenase gene 1067 Thioredoxin iron binding bicarbonate review 825 variant surface glycoprotein formation homol protein disulfide isomerase iron uptake hepatocyte ethanol 575 review 261 review 96 variant amino acid replacement 834 variant surface glycoprotein glycolipid redox mechanism property review Transformation formation 996 95 cell electroporation electroinjection Trypsin Thrombin 1018 inhibitor trypsinogen dihydroxy bile neutrophil inositol phosphate forma= epithelium cell oncogene fos 1019 salt 168 tion 280 genetic cell selection 1018 sialoglycoprotein release membrane Thromboplastin neoplastic ras PGF2alpha inositol vesicle tumor 189 apoprotein purifn brain 570 phosphate 990 Trypsinogen Thylakoid transcription class I antigen gene activation immunoassay calcium 337 protein phosphorylation fluorescence 605 dihydroxy bile salt trypsin inhibitor ATP 46 Transforming 168 Thymidine growth factor prostate 389 Tryptophan kinase leakage cell proliferation 55 Transition metab ethanol review 254 Thyrocyte metal ion carboxylate complex depro= TSH immortalization transfection plasmid tonation 406 thyroid cell line 196 197 Translocation thyroid polyamine 397 Thyroglobulin dipeptide lysosome membrane mecha• Tubocurarine autoantibody clonality autoimmune nism 42 neuromuscular transmission dia= thyroiditis 728 729 Transmitter phragm 747 Thyroid neurovegetative methylaminoethyl Tumor cell line TSH autoantibody 196 acetate adrenal 565 breast glycoprotein hormone 1026 cell oncogene transfection 197 Transport cell brain monoclonal antibody 373 hormone genetic diabetes 31 amino acid erythrocyte harmaline cell respiration uncoupler gossypol polyamine intracellular messenger 567 616 397 ammonium proton Aspergillus 969 colon growth inhibition interferon Thyroiditis calcium salivary inositol phosphate 1049 autoimmune thyroglobulin autoanti= fly 988 guanidinobenzoatase inhibitor 556 body clonality 728 729 calcium smooth muscle review 492 killing monocyte reactive oxygen Tibetan ion stomach mucosa thiocyanate species 902 terrier retina atrophy cGMP taurine methylphenylmethoxyimidazopyri= membrane vesicle sialoglycoprotein 317 dineacetonitrile 27 release trypsin 189 Tissue iron hepatocyte transferrin endocylo= necrosis factor antitrypsin mRNA connective atherosclerotic plaque cap sis 618 monocyte 1055 1032 iron intestine brush border 832 skin poxvirus EGF review 671 cytochrome P450 polyriboinosinic lithium erythrocyte 205 Turbidimetry polyribocytidylic acid 631 lithium liposome NMR 207 protein detn detergent TCA 640 mineralization membrane recognition lithium liver 208 Twitch 824 membrane dihydrolipoamide dehy= tetanic fatigue rat diaphragm 382 oxygenation detn spectrometry 978 drogenase function review 87 Type protein proteoglycan plasma insulin peptide detn erythrocyte NMR 635 I restriction enzyme evolution review IGF1 624 potassium chondrocyte 637 942 xanthine dehydrogenase oxidase potassium erythrocyte membrane Tyrosine ischemia 358 calcium neomycin 598 essential aspartate transcarbamoylase Tobacco proline chondrocyte sodium 894 wheat germ 615 smoke fibronectin bronchoalveolar protein mitochondria review 701 glutathione reductase mechanism fluid 378 reverse cholesterol spleen 282 Escherichia 84 Tocopherol rubidium detn kidney NMR 596 initiator protein REP D DNA 758 deficiency nervous system 466 taurine stoichiometry erythrocyte kinase insulin receptor regulation Toxicity pigeon 555 liver 40 paracetamol hepatocyte methylpros= uridine kidney cortex membrane 768 phosphorylation beryllium 1047 taglandin E2 641 Transposon protein kinase affinity chromatog Toxin Tn21 resolvase mechanism DNA liver 780 botulin A neurotransmission 886 supercoiling 760 Ubiquitin cholera diacylglycerol insulin fibrob= Tn3 DNA resolvase mechanism 754 protein detection antibody nucleus last 283 TRH 1059 epidermolytic binding epidermis 334 processing hypothalamus prostate UDP pertussis acid secretion stomach 281 784 glucuronosyltransferase isoenzyme TPA Trifluoperazine gene human liver 157 protein kinase C glia 294 calpain II 1043 glucuronosyltransferase liver hypothy= Transacetylation NAD metab tegument tapeworm roidism substrate 802 arylamine blood 742 868 Uncoupling Transamination Triiodothyronine protein mitochondria cold obesity amino acid metab history 600 fatty acid metab liver 1002 1009 Transcarbamoylase glucagon lipogenic enzyme liver 33 Undergraduate aspartate essential tyrosine wheat Trimethylamine curriculum biochem education 513 germ 615 oxide reductase Rhodobacter peri^ plasm 182 KEYWORD INDEX 1149

Uptake Vas Western dipeptide lysosome mechanism 42 deferens ethanol calcium channel blotting proteoglycan detection 159 iron carrier size brush border 832 blocker 381 Wheat Urea Vascular germ aspartate transcarbamoylase protein detn Bradford 382 cardiac muscle regulation 503 essential tyrosine 615 Uremia endothelium acetylcholine inositol gluten alpha gliadin isoelec focusing muscle glycogen glucose phosphate diacylglycerol 488 748 cycling 578 muscle relaxation cGMP 497 pea chloroplast gene review 704 Uridine Vasoconstriction Wolfgram transport kidney cortex membrane leukotriene heart 361 protein formation brain neuroglia 768 Vasodilation 212 Urine adenosine review 479 Wool acyl carnitine detn 796 Vasopressin electrophoresis silver staining 639 betaine newborn development 788 hepatocyte inositol phosphate 991 Wound collagen hydroxypyridinium crosslink inositol tetrakisphosphate 984 healing collagen lattice fibroblast rheumatoid arthritis 817 pyruvate metab liver 1075 328 dicarboxylic aciduria glucuronide Vein W13 ester 744 smooth muscle lipoprotein receptor calpain II 1043 glucose phosphate dehydrogenase cAMP 1008 W7 detn neoplasm 555 Vesicle calpain II 1043 glycated aspartate lysine 29 secretory purifn sucrose centrifugation Xanthine uteroglobin like protein kidney failure 51 dehydrogenase oxidase tissue ischemia 970 seminal contraction phenylephrine 358 Uroporphyrinogen Clonidine potassium 1021 Xenobiotic III synthase Escherichia 965 Vibrio metab microsome review 232 Uteroglobin hemolysin gene 638 Xenopus like protein urine kidney failure 970 lux gene cloning Lactobacillus Strep• oocyte photosensitivity retina mRNA Uterus tococcus 1068 299 alk phosphatase pregnancy 848 Vinylglycine Xylose UV phosphonate analog alanine racemase fermn ethanol Pachysolen Candida irradn neg selection CHO cell 1018 inhibition 606 recycle 198 Vaccine Virus Yeast malaria sporozoite liposome review adeno transformation antigen gene citrate synthase cDNA cloning Es• 921 transcription 605 cherichia 718 Vacuole chromosome sepn 546 cytochrome P 450 genotoxicity review ajmalicine compartmentation Cathar• SV40 DNA replication 545 1086 anthus 63 SV40 DNA replication structure 604 lipid manuf review 1088 Valine Vitamin protein formation initiation factor Capsicum culture capsaicin prodn A epidermis keratin 327 eIF2 45 66 protein manuf 1081 Variant Vol literature retrieval education 379 recombinant protein secretion review surface glycoprotein formation Trypa• 1083 nosoma review 261 Water heptane interface Chromobacter Zinc surface glycoprotein glycolipid forma• apoglycerol dehydrogenase reactiva• tion Trypanosoma 996 lipase adsorption 273 Weaning tion Bacillus 975 surface glycoprotein membrane an• insulin receptor protein kinase 896 chor review 265 liver dehydrogenase 899 624th MEETING, DUBLIN

Biogenesis of Organelles and Membrane Proteins

Bioenergetics Group/Membrane Group Joint Colloquium Organized and Edited by M. A. Harmey (University College, Dublin)

Biogenesis of mitochondrial proteins

ROSEMARY A. STUART * DONALD W. NICHOLSON,* involved in the initial recognition process of the precursors MATTHEW A. HARMEYt and WALTER NEUPERT* (Hennig & Neupert, 1981; Zwizinski et al, 1984; Pfaller & *Institut für Physiologische Chemie der Universität München, Neupert, 1987). The high-affinity binding of precursors to Goethestrasse 33, 8000 München 2, F.R.G. andt Botany both porin and cytochrome c have been studied in detail Department, University College Dublin, Republic of Ireland (Hennig etal, 1983; Pfaller & Neupert, 1987). In the case of porin, Scatchard analysis has indicated the existence of high- Eukaryotic cells, in contrast to procaryotic cells, are divided affinity binding sites present at 5-10 pmol/mg of mitochon• 8 1 into a number of compartments, each surrounded by one or drial protein and having a Ka of (l-5)xl0 M" , while more membranes. As a consequence of creating this com- binding studies with cytochrome c indicated that there were partmentalization (i.e. organelles), eukaryotic cells have 90 pmol of high-affinity binding sites per mg of mitochon• evolved a host of new capabilities compared with simple pro- drial protein. These sites had an association constant of karyotic systems. Each compartment contains a unique set of 2.2 x 107. The binding of porin to mitochondria was sensitive proteins that enables it to carry out specific functions. Thus to pretreatment of mitochondria with very low concentra• the accurate and efficient delivery of each protein to its tions of trypsin, indicating that the binding sites are of a pro• correct compartment is an important step in the maintenance teinaceous nature. These high-affinity binding sites could be and development of the cell. Here we discuss the biogenesis solubilized with detergent and reconstituted into liposomes. of mitochondria, in particular with reference to the events It has also been suggested that this porin 'receptor1 may also involved in the import of proteins into these organelles (for be involved in mediating the import of other precursor pro• other reviews see Zimmermann, 1986; Nicholson & teins such as the ADP/ATP carrier, an inner membrane pro• Neupert, 1988). tein. Less than 10% of the mitochondrial proteins are encoded Transport of precursors across the two mitochondrial for by the mitochondrial genome; the remainder being speci• membranes occurs in a single step at contact sites between fied by nuclear genes (Neupert & Schatz, 1981). In general, the outer and inner membranes (Schleyer & Neupert, 1985; these proteins are synthesized on free ribosomes as precur• Schwaiger et al, 1987). These contact sites have been shown sors, containing /V-terminal extensions, which are released to be stable structures the formation of which was not into the cytoplasm (Hallermayer et al, 1977). These precur• mediated by the presence of the precursor proteins them• sors are subsequently imported into one of the four mito• selves. Precursor proteins trapped in these contact sites chondrial subcompartments: namely, outer membrane, (translocation intermediates) have been labelled by immuno• intermembrane space, inner membrane or matrix. Although cytochemical techniques and visualized by electron micro• binding and import of mitochondrial precursors proteins scopy (Schwaiger et al, 1987). The insertion into and does not depend on a coupled translational event, it is still translocation across the outer and inner membranes are quite possible that under certain physiological conditions in dependent on an electrochemical potential (Ai/>) across the vivo, mitochondrial precursors could be imported in a co- inner membrane (Schleyer et al, 1982; Gasser et al, 1982; translational manner (Schleyer & Neupert, 1985). Pfanner & Neupert, 1986). It is possible that the Aip pro• The /V-terminal prepiece present on most mitochondrial duces an electrophoretic driving force on the positively precursor proteins contains the necessary information to charged parts of the precursor protein, which serves to target the protein to mitochondria (Hurt et al, 1984A, b\ van mediate penetration into or through the inner membrane Loon & Young, 1986). As will be discussed later, these pre- (Pfanner & Neupert, 1986; Roise etal, 1986). pieces can also play an important role in subsequent intra• The role of nucleoside triphosphates (NTPs) in the trans• mitochondrial sorting (van Loon et al, 1987; Hartl et al., port of proteins into the mitochondrion has also been investi• 1986, 1987). It is important to note, however, that some pre• gated (Pfanner & Neupert, 1986; Pfanner et al, 1987). For cursor proteins do not contain /V-terminal extensions. For example, the import of the F0Fj-ATPase subunit ß (F,/3) was example, the outer membrane proteins porin and the 70 kDa dependent on both Aip and NTPs. Non-hydrolyzable ATP protein from yeast (Mihara & Sato, 1985; Kleene et al., analogues were not able to fulfil the NTP requirement indi• 1987; Riezman, 1983; Hase et al, 1984) and cytochrome c cating that actual cleavage of a phosphodiester bond is of the intermembrane space (Zimmermann et al, 1981; necessary. It was demonstrated that the sensitivity of precur• Stuart et al, 1987) are not proteolytically processed upon sor proteins in reticulocyte lysate to non-specific proteases is import. Clearly specific targeting information for these pre• greater in the presence of NTPs (Pfanner et al, 1987). Thus, cursor proteins must reside within the mature part of the it was postulated that the hydrolysis of NTPs is involved in polypeptide itself, although it is not known whether such modulating the folding of precursors in the cytosol, and targeting information operates on the level of the primary thereby conferring a conformation that is competent for

structure or if it is dependent on a critical conformational import. A series of fusion proteins between the F0-ATPase arrangement of the protein (Nicholson etal, 1987). subunit 9 and mouse dihydrofolate reductase were con• Proteinaceous components (import receptors) on the structed which demonstrated that the import of precursors outer surface of the outer mitochondrial membrane are having identical presequences, but different mature protein

Vol. 16 701 702 BIOCHEMICAL SOCIETY TRANSACTIONS parts, required different levels of NTPs. These results are Eilers, M., Oppliger, W. & Schatz, G. (1987) EMBO J. 6. consistent with the view that the NTPs are required to confer 1073-1077 an import competent conformation on the precursor during Gasser, S. M, Ohashi, A., Daum, G., Böhni, P. C, Gibson, J., Reid. the processes of recognition and binding to the mitochondrion G. A., Yonetani, T. & Schatz, G. (1982) Proc. Natl Acad. Sei. USA 79, 267-271 (Pfanner et al., 1987; Eilers et al, 1987). Hallermayer, G., Zimmermann, R. & Neupert, W. (1977) Eur. J. During or shortly following the translocation process, pre• Biochem. 81, 523-532 cursor proteins with N-terminal presequences are proteolyti- Hartl, F.-U., Schmidt, B., Wächter, E., Weiss, H. & Neupert, W. cally processed by a metal-dependent processing peptidase (1986) Ce//47, 939-951 located in the matrix (Böhni et al, 1980; Miura et al., 1982; Hartl, F.-U., Ostermann, J., Guiard, B..& Neupert, W. (1987) Cell Schmidt et al, 1984; Hawlitschek et al, 1988). The process• 51,1027-1037 ing peptidase has recently been purified from Neurospora Hase, J., Müller, U„ Riezman, H. & Schatz, G. (1984) EMBO J. 3, crassa (Hawlitschek et al., 1988). The enzyme has been 3157-3164 shown to consist of two polypeptides of 57 kDa and 52 kDa Hawlitschek, G., Schneider, H., Schmidt, B., Tropschug, M., Hartl, F. U. & Neupert, W. (1988) Cell53, 795-806 apparent molecular mass. The peptidase activity is asso• Hennig. B. & Neupert, W. (1981) Eur. J. Biochem: SI, 533-544 ciated with the 57 kDa component and it is thought that the Hennig, B, Köhler, H. & Neupert, W. (1983) Proc. Nad. Acad. Sei. 52 kDa component is required as an 'assistant protein' which USA 80,4963-4967 functions to increase the catalytic rate and specificity of the Hurt, E. C, Pesold-Hurt, B. & Schatz, G. (1984«) EMBO J. 3, processing reaction. It is also suggested that the 52 kDa com• 3149-3156 ponent is equivalent to the product of the mas-1 gene in Hurt, E. C, Pesold-Hurt, B. & Schatz, G. (1984/?) FEBS Lett. 178, yeast, a mutant of which lacks precursor processing activity 306-310. at restrictive temperatures (Witte et al., 1988). Kleene, R., Pfanner, N., Pfaller, R., Link, T. A., Sebald, W., Neupert, Once specifically directed to mitochondria, imported pre• W. & Tropschug, M. (1987) EMBO J. 6, 2627-2633 Mihara, K. & Sato, R. (1985) EMBO J. 4,769-77'4 cursor proteins must then be correctly sorted to their func• Miura, S., Mori, M., Amaya, Y. & Tatibana, M. (1982) Eur. J. Bio• tional intramitochondrial location. Generally, sorting of chem. 122,641-647 precursors is accomplished by direct transfer to their correct Neupert, W. & Schatz, G. (1981) Trends Biochem. Sei. 6, 1 -4 mitochondrial subcompartments. In some cases, however, Nicholson, D. W. & Neupert, W. (1988) in Protein Transfer and sorting occurs by a more sophisticated mechanism (for Organelle Biogenesis (Das, R. C. & Robbins, P. W., eds.), pp. example, the precursor to the Fe/S protein of the ubiqui- 677-746, Academic Press, New York Nicholson, D. W., Stuart, R. A., Hergersberg, C. & Neupert, W. nol-cytochrome c reductase complex, cytochrome b2 and cytochrome c, (Hartl et al., 1987), all of which function in (1987) Biochem. Soc. Bull. 9, No. 3 the intermembrane space and contain a presequence which is Pfaller, R. & Neupert, W. (1987) EMBO J. 6,2635-2642 Pfanner, N. & Neupert, W. (1985) EMBO J. 4, 2819-2825 processed in two distinct steps). In these cases, the precur• Pfanner, N. & Neupert, W. (1986) FEBS Lett. 209,152-156 sors are first imported completely into the matrix where the Pfanner, N., Tropschug, M. & Neupert, W. (1987) Cell49, 815-823 first part of the presequence is removed by the processing Riezman, H., Hase, T, van Loon, A. P. G. M., Grivell, L. A., Suda, peptidase to generate an intermediate-size product. This is K. & Schatz, G. (1983) EMBO J. 2,2161-2168 then redirected back across the inner membrane to the inter• Roise, D., Hovath, S. J., Tomich, J. M., Richards, J. H. & Schatz, G. membrane space where the second half of the presequence is (\9&6) EMBO J. 5,1327-1334 proteolytically removed. Contrary to the stop-transfer model Schleyer, M. & Neupert, W. (1985) Cell43, 339-350 (van Loon & Schatz, 1987; van Loon et al., 1987), hydro• Schleyer, M., Schmidt, B. & Neupert, W. (1982) Eur. J. Biochem. phobic stretches of amino acids in the second half of the pre- 125,109-116 piece appear to act as transport signals to direct export from Schmidt, B., Wächter, E., Sebald, W. & Neupert, W. (1984) Eur. J. Biochem. 144,581-588 the matrix into the intermembrane space (Hartl et al., 1987). Schwaiger, M., Herzog, V. & Neupert, W. (1987) J. Celt Biol. 105, In summary, the import of proteins into mitochondria 235-246 involves a number of consecutive steps which act in concert Stuart, R. A., Neupert, W. & Tropschug, M. (1987) EMBO J. 6, to efficiently and specifically direct proteins to their correct 2131-2137 intracellular and intramitochondrial location. While many of van Loon, A. P. G. M. & Schatz, G. (1987) EMBO J. 6,2441 -2448 these steps are common for a large number of mitochondrial van Loon, A. P. G. M. & Young, E. T. (1986) EMBO J. 5, 161 -16 5 protein constituents (i.e. shared receptors, contact sites, Ay van Loon, A. P. G. M., Brändli, A., Pesold-Hurt, B., Blank, D. & and NTP requirements, proteolytic processing events), the Schatz, G. (1987) EMBO J. 6,2433-2439 Witte, C, Jensen, R. E., Yaffe, M. R. & Schatz, G. (1988) EMBO J. overall import pathway often varies significantly between dif• 7, 1439-1447 ferent proteins. Most of these variations are characteristic of Zimmermann, R., Hennig, B. & Neupert, W. (1981) Eur. J. Biochem. the protein's final intramitochondrial location and the events 116,455-460 which are necessary to deliver properly a protein to its Zimmermann, R. (1986) in Protein Compartmentalization (Strauss, correct functional location. The individual molecules involved A. W, Boime, I. & Kreil, G., eds.), pp. 119-136, Springer Verlag, m these processes are now the subject of current research New York interest. Zwizinski, X., Schleyer, M. & Neupert, W. (1984) J. Biol. Chem. 259,7850-7856 Böhni, P., Gasser, S., Leaver, C. & Schatz, G. (1980) in Organisation and Expression of the Mitochondrial Genome (Kroon, A. M. & Saccone, C, eds.), pp. 432-433, Amsterdam, Elsevier/North Holland Received 11 January 1988

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