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2019 ISV Congress Program ORAL PROGRAM SUNDAY OCTOBER 27, 2019 08:00‐19:00 REGISTRATION (Minneplein) 09:00‐10:00 WELCOME COFFEE (SPONSORED BY GSK) (Minneplein) 10:00‐10:10 OPENING REMARKS (Auditorium) ISV Congress co‐Chairs: Linda Klavinskis, Kings College London; Ted Ross, University of Georgia; Xavier Saelens, University of Ghent 10:10‐12:00 OPENING SESSION (Auditorium) PLENARY SESSION 1: Emerging Infectious/Neglected Diseases – Are We Making Progress? Session Chairs: David Weiner, Wistar Institute; Linda Klavinskis, King’s College London 10:10‐10:45 KEYNOTE SPEAKER Creating a world in which epidemics are no longer a threat to humanity: the challenges of developing vaccines in the 21st Century Luc Debruyne, Coalition for Epidemic Preparedness Innovations (CEPI) 10:45‐11:10 [PL1.1] Rapid emerging infectious disease response utilizing a measles vaccine vector platform Katrin Ramsauer, Themis Bioscience GmbH 11:10‐11:35 [PL1.2] Viral Vectors as a Platform Technology for Emerging Pathogen Vaccines Sarah Gilbert, Jenner Institute 11:35‐12:00 [PL1.3] Recent Advances in Tuberculosis Vaccine Development Ann Ginsberg, IAVI 12:00‐13:30 LUNCH (SPONSORED BY IMBCAMS) (Banquet Room) 13:30‐15:05 PLENARY SESSION 2: Personalized Cancer Vaccines ‐ (Auditorium) Why Being Different is Good Session Chairs: Annie DeGroot, EpiVax; Jeffrey Ulmer, GlaxoSmithKline (GSK) 13:30‐13:55 [PL2.1] Development of neoantigen‐specific cancer vaccines: From prediction of neoantigens to development of a potent vaccine Karin Jooss, Gritstone Oncology, Inc. 13:55‐14:20 [PL2.2] Discovery of actionable tumor antigens presented by MHC class I molecules Claude Perreault, Université de Montréal 14:20‐14:35 [PL2.3] Nouscom personalized and off‐the‐shelf vaccines encoding many cancer neoantigens to cure large solid tumors, in combination with checkpoint inhibitors Maria Teresa Catanese, Nouscom SRL 14:35‐14:50 [PL2.4] Active immunization with PD1‐derived B cell mimotope ‐ New strategies in cancer immunotherapy against Her‐2/neu‐expressing tumors Joshua Tobias, Medical University of Vienna 14:50‐15:05 [PL2.5] In vivo expression of plasmid encoded IgG for immune check point targets by synthetic enhanced DNA as a new tool for cancer immunotherapy Kar Muthumani, The Wistar Institute 15:05‐ 15:35 COFFEE BREAK (SPONSORED BY PFIZER) (Minneplein) 15:35‐17:55 CONCURRENT SESSION 1 CONCURRENT SESSION 2 CONCURRENT SESSION 3A (Room Jan Van Eyck) (Room Hubert Van Eyck) (Room Van der Goes) Structural and Computational What’s New in Vaccine HCMV Vaccines – Current Status Vaccine Design Formulations and Delivery & Future Projects Session Chairs: Session Chairs: Session Chair: Xavier Saelens Anna‐Lise Williamson Stanley Plotkin University of Ghent University of Capetown VaxConsult LLC Lenny Moise Karl Ljungberg University of Rhode Island Eurocine Vaccines 15:35‐16:00 [O1.1] [O2.1] [O3.1] Trivalent cocktail of de novo Polymeric adjuvants for Prospects for Vaccination designed immunogens enables enhanced vaccine induced Against Cytomegalovirus the robust induction and cellular immunity Stanley Plotkin focusing of functional antibodies Ed Lavelle Vaxconsult LLC in vivo Trinity College Dublin Bruno Correia 15:35‐15:55 Laboratory of Protein Design & Immunoengineering (LPDI) 16:00‐16:25 [O1.2] [O2.2] [O3.2] Making use of human Composite Virus‐like particles CMV: State‐of‐the‐art approach monoclonal antibodies for the (VLP) by constructing to prophylaxis prevention and treatment of intelligent artificial nano/micro Fabienne Piras‐Douce viral diseases “chassis” assembled with Sanofi Pasteur Davide Corti antigens Institute for Research in Guanghui Ma 15:55‐16:15 Biomedicine (IRB) Chinese Academy of Sciences (CAS) 16:25‐16:40 [O1.3] [O2.3] [O3.3] Immunogenicity of ultrastable Bridging systemic and Clinical Immunogenicity Profile HIV‐1 native‐like envelope gastrointestinal immune of Cytomegalovirus Vaccine trimers responses for enhanced V160 Ivan del Moral Sánchez vaccinations Dai Wang Amsterdam UMC, Academic Medical Yufei Xia Merck Center Chinese Academy of Sciences (CAS) 16:15‐16:35 16:40‐16:55 [O1.4] [O2.4] [O3.4] Co‐display of hyperstabilized Microneedle vaccination against Development of a subunit based HIV‐1 envelope glycoprotein Zika virus confers enhanced CMV vaccine trimers on two‐component cellular and humoral immunity Kirsten Schneider‐Ohrum protein nanoparticles while protecting immune GSK Mitch Brinkkemper privileged compartments Amsterdam UMC Ioanna Skountzou 16:35‐16:55 Emory University 16:55‐17:10 [O1.5] [O2.5] [O3.5] Innovative HIV‐1 Nanovaccine Th17‐polarizing mucosal CTA1‐ Vaccine efficacy against genital Adjuvanted with Army Liposome DD adjuvant generates highly HSV‐1 and HSV‐2 infection and Formulation: Glycosylated V1V2 protective CD4 T‐cell responses immune correlates of Envelope Proteins Displayed on a when used in combination with a protection for an HSV‐2 Self‐Assembling Protein universal flu vaccine candidate gC2/gD2/gE2 trivalent Nanoparticle Li Ching Ong nucleoside‐modified mRNA‐LNP Zoltan Beck University of Gothenburg vaccine for genital herpes Walter Reed Army Institute of Harvey Friedman Research University of Pennsylvania Henry M Jackson Foundation 16:55‐17:10 17:10‐17:25 [O1.6] [O2.6] CONCURRENT SESSION 3B Reconstitution of a Dengue virus A built‐in adjuvant‐engineered (Room Van der Goes) neutralizing epitope mucosal vaccine against Emerging Infectious Disease Chen Piller Fusobacterium nucleatum and Vaccines: Clinical Studies Tel Aviv University Porphyromonas gingivalis inhibits dysbiotic periodontal Session Chair: diseases in a mouse model Sarah Gilbert Joon Haeng Rhee Oxford University Chonnam National University 17:25‐17:40 [O1.7] [O2.7] [O3.6] Dengue and Zika virus domain TriMix based mRNA Ad26.ZIKV.001 induces durable III‐flagellin fusion and glycan‐ immunotherapies humoral immune responses in masking E antigen for prime‐ Stefaan De Koker humans that confer high levels boost vaccine immunization eTheRNA immunotherapies of passive protection in a Suh Chin Wu murine Zika virus challenge Institute of Biotechnology model National Tsing Hua University Nadine Salisch Janssen Vaccines B.V. 17:10‐17:25 17:40‐17:55 [O1.8] [O2.8] [O3.7] Presenting novel soluble Mucosal immunity induced by Development of a single‐shot hepatitis C virus E1E2 the intranasal delivery/adjuvant live‐attenuated Chikungunya glycoproteins on a designed two‐ NanoVaxTM ‐formulated vaccine vaccine: A Phase 1 randomized component nanoparticle to protected animals from clinical trial in healthy adults. enhance immunogenicity respiratory and genital Nina Wressnigg Kwinten Sliepen infections. A promising path to Valneva Austria Amsterdam UMC improving efficacy of existing University of Amsterdam vaccines and developing a past 17:25‐17:40 overdues ones. Ali Fattom Bluewillow Biologics [O3.8] A synthetic, consensus DNA vaccine against Middle East Respiratory Syndrome coronavirus (MERS‐CoV), GLS‐ 5300, induces robust humoral and cellular immune responses in humans Emma Reuschel The Wistar Institute 17:40‐17:55 17:55‐19:00 POSTER SESSION # 1 (Minneplein) 18:30‐20:00 WELCOME RECEPTION (SPONSORED BY EPIVAX) (Minneplein) MONDAY OCTOBER 28, 2019 07:30‐08:00 MORNING COFFEE (SPONSORED BY HIVF) (Minneplein) 08:00‐09:45 PLENARY SESSION 3: Influence of the Microbiome Shaping the (Auditorium) Immune Response to Vaccines Session Chairs: Beate Kampmann, London School. of Hygiene and Tropical Medicine (LSHTM) Margaret Liu, ProTherImmune 08:00‐08:25 [PL3.1] Modulation of Host Immunity by Targeting Gut Microbiota Sin‐Hyeog Im, Pohang University of Science and Technology (POSTECH) 08:25‐08:50 [PL3.2] The Microbiome and HIV Vaccine Response Heterogeneity James Kublin, Fred Hutchinson Cancer Research Center 08:50‐09:15 [PL3.3] The intestinal microbiota and oral vaccine immunogenicity Nick Grassly, Imperial College London 09:15‐09:30 [PL3.4] Impact of the gut microbiota on rotavirus vaccine response in Indian, African and European infants: a prospective cohort study Edward Parker, London School of Hygiene and Tropical Medicine (LSHTM) 09:30‐09:45 [PL3.5] Two‐year Follow‐up Results of an Extra‐Intestinal Pathogenic E. Coli Vaccine in Healthy Adults: ESTELLA, a Phase 2 Randomized Study Wouter Haazen, Janssen Research & Development 09:45‐10:15 COFFEE BREAK (SPONSORED BY JANSSEN) (Minneplein) 10:15‐12:20 CONCURRENT SESSION 4 CONCURRENT SESSION 5 CONCURRENT SESSION 6 (Room Jan Van Eyck) (Room Hubert Van Eyck) (Room Van der Goes) Vaccines for Respiratory HIV Vaccines – Are We Making Third Generation Vaccines Infections Progress? (RNA & DNA Vaccines) Session Chairs: Session Chairs: Session Chairs: John Oxford Jerome Kim Maria Issagouliantis Queen Mary College International Vaccine Institute Karolinska Institute Stephen Kent Hanneke Schuitemaker Shan Lu Doherty Institute Jansen Vaccines & Prevention UMASS Medical School 10:15‐10:40 [O4.1] [O5.1] [O6.1] The current TB vaccine pipeline Cleavage‐independent HIV‐1 Env A novel DNA vaccine aiming to and the TB Vaccine Development trimers elicit cross‐neutralizing quench emerging pandemic Pathway antibodies at multiple sites of threats Gerald Voss vulnerability Gunnveig Grødeland Tuberculosis Vaccine Initiative Richard Wyatt University of Oslo (TBVI) The Scripps Research Institute 10:40‐11:05 [O4.2] [O5.2] [O6.2] Augmented germinal center Advancing a global HIV vaccine Infectious RNA vaccine formation underpins enhanced candidate through the protects against Chikungunya immunogenicity of self‐ development pipeline virus infection assembling protein nanoparticle Hanneke Schuitemaker Karl Ljungberg vaccines for
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