bioRxiv preprint doi: https://doi.org/10.1101/149153; this version posted June 13, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers Authors: Meier B*1, Volkova N*2, Hong Y1, Schofield P1,3, Campbell PJ 4, 5, 6 Gerstung M2 and A Gartner1 * these authors contributed equally. Institutions: 1 Centre for Gene Regulation and Expression, University of Dundee, Dundee, UK. 2 European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL- EBI), Hinxton, Cambridgeshire, UK. 3 Division of Computational Biology, University of Dundee, Dundee, UK. 4 Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. 5 Department of Haematology, University of Cambridge, Cambridge, UK. 6 Department of Haematology, Addenbrooke’s Hospital, Cambridge, UK. Correspondence: Dr Anton Gartner Centre for Gene Regulation and Expression University of Dundee Dow Street Dundee, DD1 5EH UK. Tel: +44 (0) 1382 385809 E-mail:
[email protected] Dr Moritz Gerstung European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Hinxton, CB10 1SA Cambridgeshire UK. Tel: +44 (0) 1223 494636 E-mail:
[email protected] Keywords: DNA mismatch repair, mutational signatures, hypermutation, replication errors, POLE-4, genome integrity, C. elegans 1 bioRxiv preprint doi: https://doi.org/10.1101/149153; this version posted June 13, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission.