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Acute Pleurisy in Sarcoidosis

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Acute Pleurisy in Sarcoidosis Thorax: first published as 10.1136/thx.33.1.124 on 1 February 1978. Downloaded from Thorax, 1978, 33, 124-127 Acute pleurisy in sarcoidosis I. T. GARDINER AND J. S. UFF From the Departments of Medicine and Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London W12 OHS, UK Gardiner, I. T., and Uff, J. S. (1978). Thorax, 33, 124-127. Acute pleurisy in sarcoidosis. A 47-year-old white man with sarcoidosis presented with a six-week history of acute painful pleurisy. On auscultation a loud pleural rub was heard at the left base together with bilateral basal crepitations. The chest radiograph showed hilar enlargement as well as diffuse lung shadowing. A lung biopsy showed the presence of numerous epithelioid and giant-cell granulomata, particularly subpleurally. A patchy interstitial pneumonia was also present. He was given a six-month course of prednisolone, and lung function returned to normal. Pleural involvement by sarcoid was thought to be were unhelpful, an open lung biopsy was per- very infrequent (Chusid and Siltzbach, 1974) until formed on 19 July 1974. Small white nodules, one recent report which gave an incidence of 1 mm across, were scattered over the visceral nearly 18% (Wilen et al., 1974). However, histo- pleura, and the lung felt firmer than normal. The logically confirmed cases remain small in number, hilar lymph nodes were enlarged and a biopsy even from very large series. Beekman et al. (1976) specimen was taken from one. have stressed that it is so unusual that pleural Two weeks later he was started on prednisolone, disease in a patient with sarcoidosis is very likely 30 mg per day. This was gradually reduced and to be due to a condition other than the sarcoidosis. stopped six months later when the lung eventually http://thorax.bmj.com/ We present the case of a European man with function (Table) had returned to normal levels; acute painful pleurisy in whom the diagnosis of it has remained so since that time. sarcoidosis was confirmed histologically. Case report Table Lung function 26 June 17 July 8 Nov. Predicted A 47-year-old white man presented with a six- '74 '74 '74 values week history of right parasternal pleuritic pain Forced expiratory with nQ other respiratory symptoms. He was given volume (1 sec) 3 5 2 7 3-4 3-2-4 2 litres on October 2, 2021 by guest. Protected copyright. and the subsided one week Vital capacity 4'3 3-2 4-2 4-1-5-3 litres antibiotics, pain but Alveolar volume 4*2 4 0 4-7 later 4ppeared on the left side. A chest radiograph Transfer coefficient showed left middle and lower lobe shadowing, (Kco) 1-44 1-31 1-61 1 54-2 12 mmol/min/kPa thought to be infective in nature. He was given Total lung capacity 6-6 4.7 6-2 6'1-7-9 litres further antibiotics, but one month later the radio- graph showed the shadows to be bilateral. He had Conversion factor: CO uptake ml/min/mmHgx l 36=mmol/min/ an unproductive cough and complained of 'not kPa. being able to get enough air into the chest'. He was admitted to hospital for investigation, and a Material and method recurrence of pleural pain was accompanied by a loud pleural rub at the left base, together with Lung and lymph node tissue for light microscopy bilateral basal crepitations. The chest radiograph was fixed in formalin, processed in the standard showed bilateral hilar enlargement and there was way, and embedded in paraffin. Sections were a diffuse haze around both hila. The middle and stained with haematoxylin and eosin, Weigert's lower zone lung fields had a fine granular 'ground- impregnation for elastin counterstained with van glass' appearance. A Mantoux test was negative Gieson, reticulin stain (Gordon and Sweet), and (100 TU) and, because all sputum and blood tests Ziehl-Neelsen's stain. 124 Thorax: first published as 10.1136/thx.33.1.124 on 1 February 1978. Downloaded from Acute pleurisy in sarcoidosis 125 Lung tissue for electron microscopy was fixed in Electron microscopy confirmed that these cells glutaraldehyde, post-fixed in osmium tetroxide, were macrophages and that the alveolar septa and embedded in resin. were lined by type II pneumocytes. Direct im- munofluorescence showed an occasional fleck of Results IgG within the granulomata and numerous inflam- matory cells with intracytoplasmic IgG, IgM, and The lymph node contained numerous small epi- IgA around the granulomata and in the alveolar thelioid and giant-cell granulomata, typical of septa. No complement components were detected, sarcoid. There was no caseation and no tubercle and there was no evidence of immunoglobulins bacilli were identified. Macroscopically the lung within vessels, even in areas showing vasculitis. was peppered with numerous small, firm, white nodules, the largest 1 mm in diameter. These were Discussion present throughout the specimen but were particu- larly noticeable on the pleural surface. The lung The literature suggests that the typical patient contained numerous granulomata, similar to those with pleural involvement by sarcoid is a negress in the lymph node, both subpleurally (Fig. 1) and who has had sarcoidosis diagnosed for some years, adjacent to pulmonary arteries (Fig. 2). The granu- who has extensive radiological pulmonary involve- lomata in the lung parenchyma were larger and ment, and who presents with pleural effusions were surrounded by a zone of inflammatory cells, (Sharma and Gordonson, 1975; Chusid and Siltz- which were mainly lymphocytes with small num- bach, 1974). Pleural involvement does not neces- bers of macrophages, eosinophils, and plasma sarily cause symptoms and may be found only if cells. This infiltrate extended into the surrounding specifically sought (Beekman et al., 1976; Wilen tissue, frequently producing a localised non- et al., 1974). Classical pleural pain has been des- destructive vasculitis in the adjacent pulmonary cribed in sarcoidosis (Wilen et al., 1974), but more vessels (Fig. 2). Unassociated with the granulo- common is an atypical pain thought to be due to mata, there was a patchy interstitial pneumonitis. mediastinal lymph node enlargement (Mayock et The septa contained a mild chronic inflammatory al., 1963). Chronic asymptomatic pulmonary in- infiltrate, and there were many macrophages with- volvement is unlikely in our patient because a in the alveoli (Fig. 3). chest radiograph taken for unrelated reasons a http://thorax.bmj.com/ on October 2, 2021 by guest. Protected copyright. ~.:47~~ Fig. 1 Multiple small granulomata (some of which have coalesced) beneath the visceral pleura (Haematoxylin and eosin X45). Thorax: first published as 10.1136/thx.33.1.124 on 1 February 1978. Downloaded from 126 I. T. Gardiner and J. S. Ufi 4~~~~~~~~~~~~~~~~- Fig. 2 A granuloma adjacent to a medium-sized pulmonary artery. Inflammation in the intervening wall is well seen with preservation of the elastic plates (H and E X300). http://thorax.bmj.com/ on October 2, 2021 by guest. Protected copyright. * ~~~~~~~~A Fig. 3 Many macrophages lying free in alveolcr spaces surrounding a well-formed granuloma (H and E X300). Thorax: first published as 10.1136/thx.33.1.124 on 1 February 1978. Downloaded from Acute pleurisy in sarcoidosis 127 few months before the onset of the presenting ill- sarcoidal angiitis, as there was no necrosis of the ness was normal. vessel wall, no intimal proliferation, nor vascular The hilar haze and 'ground-glass' appearance occlusion. seen on our patient's chest radiograph, suggesting an alveolar and acinar filling process (Ziskind et We are grateful to Dr. G. W. Poole for permission al., 1963), are unusual but have been described as to publish details of a patient under his care. We highly suggestive of sarcoidosis (Rabinowitz et al., also thank Mr. W. Hinks for the photomicro- 1974). The nature of this alveolar filling process graphs and Mrs. P. Weller for secretarial help. has been unclear. Sahn and colleagues (1974) have described a case of pulmonary sarcoid with an References 'acinar' pattern on the chest radiograph. Lung biopsy revealed multiple granulomata, and the Beekman, J. F., Zimmet, S. M., Chun, B. K., Miranda, alveoli to A. A., and Katz, S. (1976). Spectrum of pleural in- adjacent these were filled with mono- volvement in sarcoidosis. Archives of Internal nuclear cells. These authors could not determine Medicine, 136, 323-330. whether the cells were blood-borne or shed from Chusid, E. L., and Siltzbach, L. E. (1974). Sarcoidosis alveolar walls. Our patient showed similar radio- of the pleura. Annals of Internal Medicine, 81, graphic appearances, and electron microscopy has 190-194. shown these cells in alveolar spaces to be Mayock, R. L., Bertrand, P., Morrison, C. E., and macrophages. Scott, J. H. (1963). Manifestations of sarcoidosis. The return of the lung function to normal sug- American Journal of Medicine, 35, 67-89. gests that steroids induced clearing of macro- Rabinowitz, J. G., Ulreich, S., and Soriano, C. (1974). phages from the alveoli, and that there was no The usual (sic) unusual manifestations of sarcoidosis and the 'hilar-haze'-a new diagnostic aid. American significant loss of pulmonary microvasculature due Journal of Roentgenology, Radium Therapy, and to the vasculitis. Nuclear Medicine, 120, 821-831. In the case reported here the histological ap- Sahn, S. A., Schwarz, M. I., and Lakshminarayan, S. pearance of the granulomata and their distribution (1974). Sarcoidosis: the significance of an acinar within the lung were typical of those described in pattern on chest roentgenogram. Chest, 65, 684-687. sarcoidosis. The granulomata were small and dis- Sharma, 0. P., and Gordonson, J. (1975). Pleural crete with no evidence of central necrosis; no effusions in sarcoidosis: a report of six cases. tubercle bacilli nor fungal elements were demon- Thorax, 30, 95-101.
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