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1 TRP About Online a TR P to Spain International Workshop on Transient Receptor Potential Channels 12th – 14th September 2012 Valencia, Spain www.trp2012.com SCHEDULE and ABSTRACTS BOOK September 2012 Dear participants, Travelling to faraway places in search of spiritual or cultural enlightenment is a millennium old human activity. In their travels, pilgrims brought with them news, foods, music and traditions from distant lands. This friendly exchange led to the cultural enrichment of visitors and the economic flourishing of places, now iconic, such as Rome, Santiago, Jerusalem, Mecca, Varanasi or Angkor Thom. The dissemination of science and technology also benefited greatly from these travels to remote locations. The new pilgrims of the Transient Receptor Potential (TRP) community are also very fond of travelling. In the past years they have gathered at various locations around the globe: Breckenridge (USA), Eilat (Israel), Stockholm (Sweden) and Leuven (Belgium) come to mind. These meetings, each different and exciting, have been very important for the dissemination of TRP research. We are happy to welcome you in Valencia (Spain) for TRP2012. The response to our call has been extraordinary, surpassing all our expectations. The speakers, the modern bards, readily attended our request to communicate their new results. At last count we were already more than 170 participants, many of them students, and most presenting their recent work in the form of posters or short oral presentations. At least 25 countries are sending TRP ambassadors to Valencia, making this a truly international meeting. We like to thank the staff of the Cátedra Santiago Grisolía, Fundación Ciudad de las Artes y las Ciencias for their dedication and excellence in handling the administrative details of the workshop. We also like to thank all the institutional and private sponsors for their generous support. In the rather depressed economic climate that we happened to be immersed in, we know that their effort is specially valuable and significant. Thanks to them we were able to balance our budget and offer 30 travel fellowships. Finally, we thank you all for coming and wish that you will find your stay in Valencia fruitful and enriching, not only in the academic but also at the personal level. We are firmly convinced that the field of TRP channels will continue to expand, with new and exciting discoveries, and we hope to learn about them from all of you in future meetings. Welcome to Valencia and we wish you have a very pleasant stay, The Scientific Committee TRP2012 International Workshop on Transient Receptor Potential (TRP) Channels i ii International Symposium on Clinical and Basic Investigation in Glioblastoma II Symposium Seve Ballesteros Foundation International Workshop on Transient Receptor Potential (TRP) Channels September 12 th - 14 th , 2012 Valencia, Spain Scientific Committee Antonio Ferrer-Montiel Universidad Miguel Hernández, Elche, Spain. Sven-Eric Jordt Yale University, New Haven, USA. Rosa Planells-Cases Leibniz-Institut für Molekulare Pharmakologie (FMP) and Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany. Félix Viana Instituto de Neurociencias de Alicante, UMH-CSIC, Alicante, Spain. Thomas Voets KULeuven, Leuven, Belgium. TRP Workshop Secretariat Cátedra Santiago Grisolía Fundación Ciudad de las Artes y las Ciencias – Comunitat Valenciana Telephone: 0034 96 197 4670 Fax: 0034 96 197 4598 E-mail: [email protected] Web: www.trp2012.com Venue Santiago Grisolía Auditorium Science Museum Príncipe Felipe City of Arts and Sciences Avinguda del Professor López Piñero (Historiador de la Medicina) nº 7 46013 - Valencia (Spain) International Workshop on Transient Receptor Potential (TRP) Channels iii iv International Symposium on Clinical and Basic Investigation in Glioblastoma II Symposium Seve Ballesteros Foundation Index Schedule ................................................................................................... 2 Lectures .................................................................................................... 7 Opening ............................................................................................................................. 8 Session 1 ........................................................................................................................... 9 Session 2 ........................................................................................................................... 15 Session 3 ........................................................................................................................... 24 Session 4 ........................................................................................................................... 31 Posters ...................................................................................................... 39 Alphabetical list of authors ..................................................................... 139 Alphabetical list of participants .............................................................. 143 International Workshop on Transient Receptor Potential (TRP) Channels Schedule Wednesday 12 th , September 2012 17.30 - 19.00 Registration 19.00 - 19.15 Opening 19.15 - 20.15 David Julius. Dept. of Physiology, University of California, San Francisco, CA, USA. Probing the structural basis of TRP channel thermo- and chemo- sensitivity 20.15 Cocktail Thursday 13 th , September 2012 Session 1 Chair: Aziz Moqrich. Dept. of Neurobiology, Institut of Developmental Biology Marseille, CNRS, Marseille, France. 09.00 - 09.40 Rachelle Gaudet. Dept. of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA. Structural determinants of TRPV channel activation and desensitization 09.40 - 10.20 Daniel Minor. Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA. Structural insights into ion channel structure and modulation 10.20 - 11.00 Jorg Grandl. Ion Channel Research Unit & Dept. of Neurobiology, Duke University Medical Center, Durham, NC, USA. The temperature-activation mechanism of TRP channels 11.00 - 11.30 Coffee break and posters view 11.30 - 12.10 Stuart Bevan. School of Biomedical Sciences, King's College London, London, UK. TRP channel-mediated sensory transduction in normal and pathophysiological conditions 12.10 - 12.50 Michael J. Caterina. Dept. of Biological Chemistry and Dept. of Neuroscience, Center for Sensory Biology. The Johns Hopkins School of Medicine, Baltimore, MD, USA. TRP channels in the skin 12.50 - 13.30 Diana Bautista. Dept. of Molecular & Cell Biology, University of California, Berkeley, CA, USA. Roles of TRP channels in itch transduction 13.30 - 15.00 Lunch 2 International Symposium on Foundation Schedule Session 2 Chair: Viktorie Vlachova. Dept. of Cellular Neurophysiology, Institute of Physiology AS CR, Prague, Czech Republic. 15.00 - 15.20 Indu S. Ambudkar. Molecular Physiology and Therapeutics Branch, NIDCR, NIH, Bethesda, MD, USA. Resolving the contributions of TRPC1 and Orai1 to regulation of salivary gland fluid secretion 15.20 - 15.40 Albert Gonzales. Vascular Physiology Research Group, Dept. of Biomedical Science, Colorado State University, Fort Collins, CO, USA. STIM1 is essential for the coupling of sarcoplasmic reticulum calcium stores to TRPM4 and BK Ca channel activity 15.40 - 16.40 Peter Zygmunt. Dept. of Laboratory Medicine, Clinical Chemistry & Pharmacology, Lund University, Lund, Sweden. Paracetamol hits the TRPs V1 and A1 16.40 - 17.20 Coffee break and posters view 17.20 - 17.40 Vera Y. Moisenkova-Bell 1 / Gregorio Fernández Ballester 2 1Dept. of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, USA. / 2Instituto de Biologia Molecular y Celular, Universidad Miguel Hernández, Elche, Alicante Spain. Structural insights into the dynamics of the TRPA1 activation mechanism 17.40 - 18.00 Víctor Meseguer. Instituto de Neurociencias de Alicante, Universidad Miguel Hernández y CSIC, Alicante, Spain. TRPA1 channels are neuronal sensors for bacterial endotoxins 18.00 - 18.20 Susan D. Brain. Vascular Biology Group and Centre for Integrative Biomedicine; Cardiovascular Division, King’s College London, London, UK. TRPA1: A link between pain exacerbation in the arthritic joint in cold environments 18.20 - 18.40 Debapriya Ghosh. Laboratory of Ion Channel Research, Dept. of Molecular Cell Biology, Katholieke Universiteit Leuven, Leuven, Belgium. Characterization of the trafficking of human transient receptor potential melastatin 8 (hTRPM8) channel by total internal reflection fluorescence (TIRF) microscopy 18.40 - 19.00 Xuming Zhang. Dept. of Pharmacology, University of Cambridge, Cambridge, UK. Modulation of the cold-activated TRPM8 channel: The role of Gq protein and PIP2 19.00 - 19.20 Rosa Señarís. Dept. of Physiology (CIMUS), Universidad de Santiago de Compostela, Spain. TRPM8-deficient mice develop obesity and metabolic syndrome. Role of TRPM8 in the regulation of energy homeostasis 19.20 - 19.25 Announcements International Workshop on Transient Receptor Potential (TRP) Channels 3 Schedule Friday 14 th , September 2012 Session 3 Chair: Scott Earley. Vascular Physiology Research Group, Dept. of Biomedical Science, Colorado State University, Fort Collins, CO, USA. 09.00 - 09.40 Miguel A. Valverde. Laboratory of Molecular Physiology and Channelopathies, Universitat Pompeu Fabra, Barcelona, Spain. TRPV4 regulation and population genetics 09.40 - 10.20 Maria G. Belvisi. Imperial College London, London, UK. TRP channels
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