Management of Refractive Surgery in Refractive Abnormalities
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History of Refractive Surgery
History of Refractive Surgery Refractive surgery corrects common vision problems by reshaping the cornea, the eye’s outermost layer, to bend light rays to focus on the retina, reducing an individual’s dependence on eye glasses or contact lenses.1 LASIK, or laser-assisted in situ keratomileusis, is the most commonly performed refractive surgery to treat myopia, hyperopia and astigmatism.1 The first refractive surgeries were said to be the removal of cataracts – the clouding of the lens in the eye – in ancient Greece.2 1850s The first lensectomy is performed to remove the lens 1996 Clinical trials for LASIK begin and are approved by the of the eye to correct myopia.2 Food & Drug Administration (FDA).3 Late 19th 2 Abott Medical Optics receives FDA approval for the first Century The first surgery to correct astigmatism takes place. 2001 femtosecond laser, the IntraLase® FS Laser.3 The laser is used to create a circular, hinged flap in the cornea, which allows the surgeon access to the tissue affecting the eye’s 1978 Radial Keratotomy is introduced by Svyatoslov Fyodorov shape.1 in the U.S. The procedure involves making a number of incisions in the cornea to change its shape and 2002 The STAR S4 IR® Laser is introduced. The X generation is correct refractive errors, such as myopia, hyperopia used in LASIK procedures today.4 and astigmatism.2,3 1970s Samuel Blum, Rangaswamy Srinivasan and James J. Wynne 2003 The FDA approves the use of wavefront technology,3 invent the excimer laser at the IBM Thomas J. Watson which creates a 3-D map of the eye to measure 1980s Research Center in Yorktown, New York. -
Perioperative Assessment for Refractive Cataract Surgery
642 REVIEW/UPDATE Perioperative assessment for refractive cataract surgery Kendall Donaldson, MD, MS, Luis Fernandez-Vega-Cueto, MD, PhD, Richard Davidson, MD, Deepinder Dhaliwal, MD, Rex Hamilton, MD, Mitchell Jackson, MD, Larry Patterson, MD, Karl Stonecipher, MD, for the ASCRS Refractive–Cataract Surgery Subcommittee As cataract surgery has evolved into lens-based refractive surgery, decisions regarding the power of the IOL to be implanted during cata- expectations for refractive outcomes continue to increase. During ract surgery. However, with all the available technology, it can be diffi- the past decade, advancements in technology have provided new cult to decipher which of the many technologies is necessary or best ways to measure the cornea in preparation for cataract surgery. for patients and for practices. This article reviews currently available The increasing ability to accurately estimate corneal power allows options for topography, tomography, keratometry, and biometry in determination of the most precise intraocular lens (IOL) for each pa- preparation for cataract surgery. In addition, intraoperative aberrom- tient. New equipment measures the anterior and posterior corneal etry and integrated cataract suites are reviewed. surfaces to most accurately estimate corneal power and corneal ab- errations. These measurements help surgeons make the best J Cataract Refract Surg 2018; 44:642–653 Q 2018 ASCRS and ESCRS ver the past 2 decades, we have experienced an only the anterior corneal surface with the use of topo- evolution in cataract surgery from simply the graphic devices; however with discovery of the impact of O removal of the cloudy lens to a refractive proced- posterior corneal astigmatism, we can now achieve higher ure that provides patients with increasingly higher levels degrees of accuracy by taking into account the effect of the of spectacle independence. -
Effects of Depth of Incision on Final Outcome in Radial Keratotomy N
Effects of Depth of Incision on final outcome in Radial Keratotomy N. Raja, M. K. Niazi B-35, PAF Complex, Sector E-9, Islamabad. Abstract Objective: To assess the effect of depth of incision on the final outcome of radial keratotomy for correction of myopia. Methods: Sixty-five eyes with preoperative uncorrected myopia between 2.5-6.0D in subjects with a mean age of 29.2 (+7) years underwent radial keratotomy between Sept 1999--July 2002 in department of Ophthalmology, Military Hospital, Rawalpindi. Based on their preoperative depth of incision the eyes were divided into group-A (twenty-five eyes), with an incision depth of 500-530 µm, and Group-B (forty eyes), with an incision depth of 531- 560 µm. The comparison between the postoperative visual acuity of two groups was made at the end of study after one years` follow up. Results: A total of Sixteen eyes in Group-A (64%) that were within one diopter of emmetropia at first follow-up reverted back to their preoperative myopic state after one year of surgery as compared to only two eyes (5%) in Group-B (p<0.05). Hyperopic shift occurred in two eyes (8%) in Group-A, as compared to four eyes (10%) of Group-B (p >0.05). After one year, refraction showed that only 24% cases of Group-A were within 1 diopter of emmetropia as compared to 85% cases in Group-B. Similarly, 40% cases of Group-A were within 2 diopters of emmetropia as compared to 90% cases of Group-B. Glare and variation of vision in the initial four weeks were the most frequently reported complications in both groups. -
Iol Calculations for Patients with Keratoconus
s THE LITERATURE IOL CALCULATIONS FOR PATIENTS WITH KERATOCONUS Work continues to improve refractive accuracy in this patient population. BY ALICE ROTHWELL, MBCHB, AND ANDREW M.J. TURNBULL, BM, PGCERTMEDED, PGDIPCRS, FRCOPHTH INTRAOCULAR LENS POWER CALCULATION TABLE 1. CLASSIFICATION OF KERATOCONUS SEVERITY IN EYES WITH KERATOCONUS Stage Keratometry Reading Savini G, Abbate R, Hoffer KJ, et al1 1 ≤ 48.00 D Industry support: K.J.H. licenses 2 > 48.00 D registered trademark name Hoffer to various companies 3 > 53.00 D ABSTRACT SUMMARY spherical equivalent. Myopic and stage 1 disease. Accuracy decreased Savini and colleagues compared hyperopic surprises were indicated by with more advanced keratoconus, with the prediction errors (PEs) of negative and positive PEs, respectively. a MedAE of greater than 2.50 D in all five standard formulas: Barrett Mean error (ME), median absolute stage 3 eyes. Universal II (BUII), Haigis, Hoffer Q, error (MedAE), mean absolute error, Holladay 1, and SRK/T. The study and percentage of eyes achieving within DISCUSSION included 41 consecutive keratoconic ±0.50 D, ±0.75 D, and ±1.00 D of the Keratoconus presents multiple eyes undergoing phacoemulsification refractive target were also calculated. challenges to IOL selection. First, and IOL implantation. Eyes were A hyperopic ME was found across all the standard keratometric index classified by disease severity (Table 1). five formulas. Across the whole dataset, cannot reliably be applied to these A subjective refraction was obtained the lowest ME (0.91 D) and MedAE eyes because this index depends on for each eye at 1 month postoperatively. (0.62 D) and the highest percentage a normal ratio between the anterior The PE for each eye was calculated by (36%) of eyes within ±0.50 D of target and posterior corneal surfaces, but subtracting the predicted spherical were achieved with the SRK/T formula. -
Analysis of Human Corneal Igg by Isoelectric Focusing
Investigative Ophthalmology & Visual Science, Vol. 29, No. 10, October 1988 Copyright © Association for Research in Vision and Ophthalmology Analysis of Human Corneal IgG by Isoelectric Focusing J. Clifford Woldrep,* Robin L. Noe,f and R. Doyle Stulringf Parameters which regulate the localization and retention of IgG within the corneal stroma are complex and poorly understood. Although multiple factors are involved, electrostatic interactions between IgG and anionic corneal tissue components, ie, proteoglycans (PG) and glycosaminoglycans (GAG) may regulate the distribution of antibodies within the corneal stroma. Isoelectric focusing (IEF) and blotting analysis of IgG revealed a restricted pi profile for both central and peripheral regions of the normal cornea. Similar analysis of pathological corneas from keratoplasty specimens in Fuchs' dys- trophy and keratoconus reveal a variable IEF profile. In the majority of keratoplasty specimens from patients with corneal edema or graft rejection, there was generally little or no IgG detectable. These results suggest that in edematous corneas where there is altered PG/GAG in the stroma and modified fluid dynamics, there is a concomitant loss of IgG. These findings may have implications for immuno- logic surveillance and protection of the avascular cornea. Invest Ophthalmol Vis Sci 29:1538-1543, 1988 The humoral immune system plays an important the soluble plasma proteins through ionic interac- role in mediating immunologic surveillance and pro- tions. The PGs and GAGs have long been known to -
Management Modalities for Keratoconus an Overview of Noninterventional and Interventional Treatments
REFRACTIVE SURGERY FEATURE STORY EXCLUSIVE ONLINE CONTENT AVAILABLE Management Modalities for Keratoconus An overview of noninterventional and interventional treatments. BY MAZEN M. SINJAB, MD, PHD anagement of keratoconus has advanced TAKE-HOME MESSAGE during the past few years, and surgeons can • When evaluating patients with keratoconus, ask now choose among numerous traditional and them to stop using RGP contact lenses at least 2 modern treatments. Traditional modalities weeks before evaluation to achieve correct Msuch as spectacle correction, contact lenses, penetrating measurement of the corneal shape. keratoplasty (PKP), and conductive keratoplasty (CK) • Interventional management modalities include CK, are still effective; however, demand for the last two has PKP, DALK, ICRSs, CXL, phakic IOLs, or some decreased with the advent of modern alternatives, specifi- combination of these treatments. cally intrastromal corneal ring segments (ICRSs) and cor- • Making the right management decision depends neal collagen crosslinking (CXL). Caution should be used on the patient’s corneal transparency and stress when considering these newer treatment modalities, and lines, age, progression, contact lens tolerance, surgeons should be aware of their indications, contraindi- refractive error, UCVA and BCVA, K-max, corneal cations, conditions, and complications before proceeding thickness, and sex. with treatment. Keratoconus treatments can be divided into two cate- Some patients achieve good vision correction and comfort gories, interventional and noninterventional. In this article, with this strategy. particular attention is given to ICRSs and CXL, as they are Advances in lens designs and materials have increased the the most popular emerging interventional management proportion of keratoconus patients who can be fitted with modalities for keratoconus. -
Managing a Patient with Post-Radial Keratotomy and Sjogren's Syndrome with Scleral Contact Lenses
Managing a patient with Post-Radial Keratotomy and Sjogren's Syndrome with Scleral Contact Lenses Case Report 1 Candidate #123 Abstract: Surgeons used radial keratotomy (RK) in the past as an attempt to flatten the corneal shape and reduce refractive myopia in a patient. In the present day, many post-RK patients suffer from poor, fluctuating vision due to an irregular corneal shape induced from this procedure. Rigid gas permeable lenses, such as scleral lenses, are an excellent solution to improve and stabilize vision. Scleral lenses help recreate an optimal refractive surface to enhance vision for the patient. Patients with specific dry eye symptoms can receive a therapeutic benefit from scleral lens use as the lens acts as a protective barrier for corneal hydration. This is a case report on a patient suffering from both ocular and systemic conditions resulting in decreased vision and discomfort from severe dry eye. She has been successfully fit with scleral lenses to improve signs and symptoms. Key Words: Radial keratotomy (RK), dry eye, Sjogren's syndrome, scleral lens 2300 East Campbell Avenue, Unit 316 Phoenix, AZ 85016 [email protected] (480) 815-4135 1 Introduction: Patients may present to their eye care provider with multiple conditions impacting 2 both their ocular and systemic health. Ocular comorbidities frequently lead to visual impairment 3 and decreased quality of life. To suitably manage these coinciding ailments, it is essential to 4 obtain an early and proper diagnosis. [1] In some instances, similar approaches can help alleviate 5 patient symptoms in managing these comorbidities. 6 7 The goal of refractive surgery is to eliminate the dependency on glasses and contact lenses. -
Radial Keratotomy: a Review of 300 Cases Br J Ophthalmol: First Published As 10.1136/Bjo.76.10.586 on 1 October 1992
586 British JournalofOphthalmology 1992; 76: 586-589 Radial keratotomy: a review of 300 cases Br J Ophthalmol: first published as 10.1136/bjo.76.10.586 on 1 October 1992. Downloaded from A K Bates, S J Morgan, A D McG Steele Abstract were utilised depending on degree of myopia. Three hundred consecutive cases of radial Finally the incisions were carefully irrigated with keratotomy performed between 1985 and 1990 sterile saline, topical antibiotics were instilled, were reviewed. There were no sight and the eye was padded. threatening complications of surgery and no Postoperatively all patients received patient lost one or more lines of corrected prednisolone sodium drops 0 3% and chloram- Snelien acuity. Overall 78*7% saw 6/12 or phenicol drops four times daily for 4 weeks. better unaided postoperatively and 51*7% saw Patients were routinely reviewed at 2 and 6 6/6 or better. Refraction showed 61*3% to be weeks after surgery and then at 3, 6, 12, and 18 within 1 dioptre ofemmetropia and 86*7% were months. within 2 dioptres. Further analysis demon- strated that results of unaided acuity and proximity to emmetropia were much better for Results low (<-2.87 D) and moderate (-3.0 to -5*87 Three hundred procedures were performed on D) than for high (>-6-0 D) myopes. 169 patients ofwhom 100 were male. All were 21 (BrJ Ophthalmol 1992; 76: 586-589) years of age or older. The age of the patients at surgery is shown in Figure 1 and it may be seen that the majority fall within the 21-30 years age Currently myopia is being treated by radial group. -
Scleral Lenses and Eye Health
Scleral Lenses and Eye Health Anatomy and Function of the Human Eye How Scleral Lenses Interact with the Ocular Surface Just as the skin protects the human body, the ocular surface protects the human Scleral lenses are large-diameter lenses designed to vault the cornea and rest on the conjunctival tissue sitting on eye. The ocular surface is made up of the cornea, the conjunctiva, the tear film, top of the sclera. The space between the back surface of the lens and the cornea acts as a fluid reservoir. Scleral and the glands that produce tears, oils, and mucus in the tear film. lenses can range in size from 13mm to 19mm, although larger diameter lenses may be designed for patients with more severe eye conditions. Due to their size, scleral lenses consist SCLERA: The sclera is the white outer wall of the eye. It is SCLERAL LENS made of collagen fibers that are arranged for strength rather of at least two zones: than transmission of light. OPTIC ZONE The optic zone vaults over the cornea CORNEA: The cornea is the front center portion of the outer Cross section of FLUID RESERVOIR wall of the eye. It is made of collagen fibers that are arranged in the eye shows The haptic zone rests on the conjunctiva such a way so that the cornea is clear. The cornea bends light the cornea, overlying the sclera as it enters the eye so that the light is focused on the retina. conjunctiva, and sclera as CORNEA The cornea has a protective surface layer called the epithelium. -
Anterior Segment Surgery and Complications CATARACT EXTRACTION and INTRAOCULAR LENS IMPLANTATION
10 Anterior Segment Surgery and Complications CATARACT EXTRACTION AND INTRAOCULAR LENS IMPLANTATION Complications PENETRATING KERATOPLASTY Complications Correction of Astigmatism in a Corneal Graft LAMELLAR KERATOPLASTY SUPERFICIAL KERATECTOMY EXCIMER LASER PHOTOTHERAPEUTIC KERATECTOMY CONJUNCTIVAL FLAP LIMBAL STEM CELL TRANSPLANTATION PTERYGIUM EXCISION AND CONJUNCTIVAL AUTOGRAFT CONJUNCTIVAL AND CORNEAL TUMOR EXCISION CORNEAL PERFORATION SURGERY PERMANENT KERATOPROSTHESIS REFRACTIVE SURGERY Radial Keratotomy Excimer Laser Photorefractive Keratectomy Laser In Situ Keratomileusis CONCLUSION Anterior segment surgery ranges from routine cataract extraction and lens implantation, one of the most common surgical operations in the United States, to rarely performed surgery such as permanent keratoprosthesis. It also encompasses surgery first performed centuries ago, such as rudimentary pterygium excision, to the latest in keratorefractive surgery. CATARACT EXTRACTION AND INTRAOCULAR LENS IMPLANTATION The many reasons for the development of cataracts are discussed in detail in Chapter 8. Most cataracts are acquired, but they can also be congenital. This section focuses primarily on the treatment of acquired cataracts in adults. Cataracts in adults are generally age related, but some lens opacities may result from other causes such as trauma, inflammation, systemic illness such as diabetes, or medications such as corticosteroids. Cataracts generally advance slowly over years but can advance rapidly over months, or even faster in some patients. The primary indication for cataract extraction is diminished vision caused by the cataract, significantly affecting the patient's lifestyle. The exact point at which this hardship occurs depends on the patient. Certain patients require little visual function and may delay cataract surgery for years or indefinitely. Other patients with high visual needs seek cataract surgery with much smaller degrees of visual loss. -
Association Between Visual Field Damage and Corneal Structural
www.nature.com/scientificreports OPEN Association between visual feld damage and corneal structural parameters Alexandru Lavric1*, Valentin Popa1, Hidenori Takahashi2, Rossen M. Hazarbassanov3 & Siamak Yousef4,5 The main goal of this study is to identify the association between corneal shape, elevation, and thickness parameters and visual feld damage using machine learning. A total of 676 eyes from 568 patients from the Jichi Medical University in Japan were included in this study. Corneal topography, pachymetry, and elevation images were obtained using anterior segment optical coherence tomography (OCT) and visual feld tests were collected using standard automated perimetry with 24-2 Swedish Interactive Threshold Algorithm. The association between corneal structural parameters and visual feld damage was investigated using machine learning and evaluated through tenfold cross-validation of the area under the receiver operating characteristic curves (AUC). The average mean deviation was − 8.0 dB and the average central corneal thickness (CCT) was 513.1 µm. Using ensemble machine learning bagged trees classifers, we detected visual feld abnormality from corneal parameters with an AUC of 0.83. Using a tree-based machine learning classifer, we detected four visual feld severity levels from corneal parameters with an AUC of 0.74. Although CCT and corneal hysteresis have long been accepted as predictors of glaucoma development and future visual feld loss, corneal shape and elevation parameters may also predict glaucoma-induced visual functional loss. While intraocular pressure (IOP), age, disc hemorrhage, and optic cup characteristics have been long identifed as classic risk factors for development of primary open-angle glaucoma (POAG)1,2, the Ocular Hypertension Treatment Study (OHTS) suggested central corneal thickness (CCT) as a new risk factor for development of POAG3. -
Cataract Post RK the Problems
2/26/2017 By Alaa El Zawawi Prof. of Ophthalmology - Alexandria University EGYPT Radial Keratotomy (RK) was a popular refractive surgical procedure to correct myopia in the 1980s before the advent of excimer laser for refractive treatment. Today, these patients are at least 30 years older and some of them have developed cataract. 1 2/26/2017 • Biometry after RK is fundamentally different. • The problem is in the keratometric measurement. • RKs result in corneal flattening in the center and corneal steepening, or bulging, in the periphery. • The more the cuts the more the effect (4, 8, 16) • The smaller the optical zone the more the effect 2 2/26/2017 • In some eyes, this central flattening progressed with time resulting in hyperopic shifts and also progressive against- the-rule astigmatism* *Holladay JT, Lynn M, Waring GO, et al. The relationship of visual acuity, refractive error and pupil size after radial keratotomy. Arch Ophthalmol 1991:109:70-76. 1- Manual Keratometry: Measures at 3.2 mm optical zone missing the central flatter zone of effective corneal power. The available instruments, such as the Javal-Schiotz keratometer, make too many assumptions, not taking into account irregular corneal astigmatism. Least accurate method in RK cases. 3 2/26/2017 2- Automated Keratometry: More accurate than manual keratometers in corneas with small optical zone (< = 3 mm) RKs, because they sample a smaller central area of the cornea (2.6 mm). It almost always gives a central corneal power that is greater than the true refractive power of the cornea. This error occurs because the samples at 2.6 mm are very close to the paracentral knee of the RK.