September 23, 1986 Vol. XXXVIII No. 19

U.S. Department of Health and Human Services

National Institutes of Health Recori� Dr. Gordon Wallace Retires; Dr. Phillip Gorden Named Director of NIDDK Gets Commendation Medal Dr. Phillip Gorden has been appointed Di­ Dr. Gordon Wallace, scientist-administrator rector of the National Institute of Diabetes and with the National Institute of Allergy and In­ Digestive and Kidney Diseases, a bureau of the fectious Diseases for the past 26 years, retired National Institutes of Health, Dr. James B. recently from Federal service. At his retirement Wyngaarden, NIH Director, has announced. celebration, Dr. Anthony S. Fauci, Director of Dr. Gorden, an internationally recognized NIAID, presented the PHS Commissioned Of­ expert in diabetes, endocrinology and metabo­ ficers' Commendation Medal to Dr. Wallace lism, assumed his new position Sept. 5. Dr. "for outstanding accomplishments during 32 Gorden had been chief of the diabetes branch of years in the Public Health Service in NIDDK since 1983 and also served as clinical biomedical research, public health, and science director, NIDDK Division of Intramural Re­ administration." search. Dr. Gorden had also been chief of the section on clinical and cellular biology of the diabetes branch since 1978. For the past 8 years, Dr. Gorden also held appointments as clinical professor of medi­ cine, Uniformed Services Medical School, Bethesda, Md., and clinical associate professor, Howard University School of Medicine, Wash­ Dr. Gorden ington, D.C. sulin secretion, heterogeneity of circulating Dr. Gorden has been a research scientist polypeptide hormones, hypoglycemic states and with NIDDK for the past 20 years. From 1976 disorders of growth hormone secretion. In col­ to 1978, he was a visiting professor at the In­ laboration with leading scientists in the diabe­ stitute of Histology and Embryology at the tes field, he has extensively studied insulin­ University of Geneva School of Medicine, Ge­ resistent states in man, espec;:ially those neva, Switzerland. Dr. Gorden was recently characterized by disorders of the insulin recep­ presented an honorary doctor's degree by the tor and has pioneered work on receptor medi­ university for collaborative research relating to cated endocytosis of polypeptide hormones. diabetes and the mechanisms of insulin action, Dr. Gorden was born in Baldwin, Miss., which has been conducted with the university Dec. 22, 1934. He received his M.D. degree over the past 10 years. from Vanderbilt University in Nashville, Dr. Anthony S. Fauci, NIAID Director ( /), con­ His research interests include disorders of in- gratulates Dr. Gordon W a/lace at a recent retire­ (See APPOINTMENT, Page 7) ment celebration. Dr. Wallace is holding his PHS Commissioned Officers' Commendation Medal. Gallo Wins Lasker Prize Dr. Robert C. Gallo, chief of NCI's Labora­ Dr. Wallace began his distinguished career tory of Tumor Cell Biology, has won the 1986 as an epidemic intelligence service officer for Lasker Clinical-Medical Research Award. the Communicable Disease Center (CDC), now Dr. Gallo is being recognized "for his intel­ the Centers for Disease Control, in Atlanta, lectual and scientific leadership in researching Ga. He joined NIAID in 1962 as a staff mem­ AIDS (Acquired Immune Deficiency Syndrome) ber of the Institute's Pacific Research Section in and for proving this disease is caused by a Honolulu, HA. There he studied eosinophilic retorvirus," the Albert and Mary Lasker Foun­ meningitis, a central nervous system disease of dation announcement indicated. man. Dr. Wallace was responsible for the dis­ He will share the clinical-medical award covery of the etiologic agent (a rat nematode) with Dr. Myron Essex (DVM-Harvard School and helped to elucidate the natural history, of Public Health) and Dr. Luc Montagnier of mode of transmission, and clinical spectrum of the Pasteur Institute in Paris. this disease. The 1982 award is the second Lasker award He and his associates were also responsible Dr. Gallo has received. for the discovery that felines are the definitive In 1982, he won the basic research award for hosts for Toxoplasma gondii, a common proto­ "his pioneering studies that led to the discovery zoan parasite that produces serious central nerv­ of the first human RNA tumor virus and its as­ ous system disease in humans when congeni­ sociation with certain leukemias and tally transmitted. Until these studies, only one lymphomas." I mode of transmission (consumption of the cyst Dr. Gallo is the first scientist to win both Dr. Mary Lou Pardue, professor of biology at the stage in raw or poorly cooked meat) of the par- the Lasker basic and clinical-medical awards. Massachusetts Institute of Technology, will deliver Since the Lasker awards were established in the fifth annual DeWitt Stetten Jr. Lecture on (See DR. WALLACE, Page 6) 1944, 42 Lasker award recipients have gone on Wednesday, Oct. 8, at 3:30 p.m. in the Masur to win Nobel Prizes. D Auditorium at the Clinical Center. Page 2 The Record September 23, 1986

TRAINING TIPS Training for Investigators On Research Animal Use THE NIH TRAINING CENTER, Division of Personnel Management offers the following: A training course on "Using Animals in In­ tramural Research: Guidelines for Investiga­ Courses and Programs Dates tors" will be presented on Thursday, Oct. 30 Management and Supervisory 496-6371 from 8:30 a.m. to 12:30 p.m. Working with Personal Differences 10/28 The course will be jointly presented by the Strategic Planning for Productive 10/24 NIH Animal Research Committee and the Results NIH Training Center. This is the sixth session Interpersonal Relationships in the Work 10/14 of a regularly scheduled course designed to help Environment NIH Managing Behavior in the Work 10/29 the Institutes obtain training for staff in Environment policies and guidelines. Using Animals in Intramural Research: 10/30 Topics covered will include: The National Institutes of Health was awarded the Guidelines for Investigators • Public interest and humane treatment of 1986 Distinguished Service Award of the Lupus Office Skills 496-6211 animals, Foundation of America "for its (NIH's) ongoing, Advanced Typing 10/14 • Principles and polices for animal use at NIH, vigorous support of biomedical research and clinical Introduction to Working at NIH 10/15 • Investigator responsibilities, investigations of immunologic diseases, specifically Time & Attendance 10/15 • Technical information and training opportuni­ lupus." Dr. James B. Wyngaarden (r) is shown ac­ Travel Orders & Vouchers 10/20 ties for NIH animal users, and Intro to Basic Microcomputers for 10/27 cepting the award emblem as Dr. Lawrence E. • Panel discussion of audience questions. Shulman, Acting Director of NIAMS, looks on. Professionals The October class can accomodate 100 per­ Special Programs 496-6211 sons. A sign-language interpreter will be avail­ Adult Education Continuously able for the hearing impaired. Announcements Training & Development Services Available Singles' Party Oct. 2 Program are available from Institute personnel offices and chairpersons of Institute animal research SHARE TRAINING: An online catalog committees. Registration is requested by Oct. "Fun For One," the R&W club forsingles, is available by accessing WYLBUR. Enter 10. having a New Year's Eve party Thursday, Oct. SHARE TRAINING. First-time users only, For more information, contact Dr. James 2 from 5 to 7 p.m. called "Let's Get Fiscal." enter: x fr &agslugL.@@share(setup) on file Harwell, 496-1076, or the NIH Training Cen­ The party will be held at the FAES house on 37. ter, 496-6371. D Cedar La. and Old Georgetown Rd. Light refreshments will be served. Admis­ sion will be $1 for members; $2 for those who NCI Scientists Win Biometric Award haven't joined by the end of the evening. D The American Sratistical Association recently NIH Science Writers' Guild presented its annual George w·. Snedecor Award to Drs. Mitchell H. Gail and Richard To Hold Meeting October 3 Simon of the National Cancer Institute. The Snedecor Award is given each year for TheNIH Record The NIH Science Writers' Guild will hold Published biweekly at Bethesda, Md., by the Edirorial Operations the best publication in the field of biometry. Branch, Division of Public Information, for the information of its first meeting of the new season on Friday, The winning paper, entitled "Testing for Qual­ employees of the National Institutes of Health, Department of Oct. 3, from 12:15 to 1: 15 p.m., Bldg. 31, irative Interactions Between Treatment Effects Health and Human Services, and circulated by request ro writers NIH Rm. 8A28. Ann Cahill, Audiovisual and Patient Subsets" appeared in Biometrics in and to researchers in biomedical and related fields. The content is Branch, OD, will describe her recent experi­ reprintable without permission. Pictures may be available on 1985. This paper presents a simple test for de­ request. ence working as an intern with TV-Channel 9's termining whether a new treatment is benefi­ medical news team and explain what it is like cial, compared to control therapy, for some NIH Record Office Staff Correspondents: to cover NIH from the other side of the camera subsets of patients and harmful for other Bldg. 31, Room 2B-03 CC, Richard McManus Phone 496-2125 DCRT, Joan P. Sobel and microphone. subsets of patients. The NIH Science Writers' Guild, formed in DPM, Harry Marshall Dr. Gail heads the Epidemiological Methods Editor DRG, Sue Meadows 1985, pursues high standards of professional­ Section, Biostatistics Branch, in the Division of Herschel Cribb DRR, Barbara Menick ism in science writing and health Cancer Etiology. Dr. Simon is chief of the DRS, Jim Doherty NIH, Staff Writers communications throughout fosters good Biometric Research Branch in the Division of FIC, Susan P. Stark relations between the NIH information offices, Joyce F. McCarthy NCI, Patricia A. Newman Cancer Treatment. D Anne Barber NE!, Marsha Corbett the NIH scientific community, and the press, NHLBI, Larry Blaser and promotes camaraderie and information ex­ Editorial Assistant NIA, Claire McCullough change among writers at NIH. Apnea Study Volunteers Sought Marilyn Berman NIAID, Jeanne Winnick Meetings are open to anyone. Questions or NIADDK, Eileen Corrigan suggestions may be addressed to members of NIMH is seeking people with sleep apnea for NICHD, James Hadley The NIH Record reserves the right NIDR, Jody Dove the guild's steering committee: Lynn Cave pharmacological research. Participants must be NIEHS, Hugh J. Lee (NINCDS), Claudia Feldman (NEI), Maureen between the ages of 25 and 60. Females of to make corrections, changes, or deletions in submitted copy in NIGMS, Wanda Warddell Gardner and Tineke Haase (NICHD), Bill Hall childbearing potential are not eligible. conformity with the policies of NIMH, Marilyn Sargent (NIAMS/NIDDK), Sandy Hecker (NIAID), For more information call Holly, the paper and HHS. NINCDS, Carol Rowan and Clementine Sessoms (NIAMS/NIDDK). 496-1057. NLM, Roger L. Gilkeson 0 0 ORS, Sylvia Funk Page 3 The Record September 23, 1986

Memorial Service for NI NCDS World Congress on Medical Informatics Scientist, Dr. Choh-Luh Li Will Be Held in Washington, Oct. 26-30

A memorial service will be held Oct. 5 at 5 Forty-nine scientific demonstrations covering • The HELP System: A System for Clinical p.m. in the 14th floor auditorium of Bldg. 10 decision support, expert systems, medical edu­ Decisionmaking for Dr. Choh-Luh Li, a former neurosurgeon cation, medical research, and many other areas, • H.E.A.R.T: Heart Emergencies Rules for Triage and neurophysiologist with the NINCDS Sur­ will be presented at MEDINFO 86. • Let the Computer Analyze Your Nursing Decisions gical Neurology Branch. Dr. Li, 72, died Aug. MEDINFO, the fifth World Congress on • ELIAS, A System for the General Practitioner 23 at his home in Bethesda after a heart attack. Medical Informatics, will be held in the U.S. • An Intelligent Information Retrieval System for Laser Disc Medical Archives Dr. Li retired in 1983 after 29 years with for the first time from Oct. 26-30 at the • Decision-Making 6.0: Update of a Microcomputer NINCDS. His career with the Institute com­ Washington Sheraton Hotel. System for Decision Analysis bined research on patients who had epilepsy, MEDINFO is the largest meeting of its • The ONCOCIN and OPAL Systems brain tumors, or Parkinson's disease with basic kind, bringing together major worldwide med­ • A Workstation for Interactive Display and Quantita­ laboratory studies on pain and epilepsy. ical societies, health care associations and com­ tive Analysis of 3-D and 4-D Biomedical Images In his early years at NINCDS, he performed puter organizations. Two NIH Directors have a • The AI/RHEUM Knowledge-Based Consultant Sys­ surgery on many epilepsy patients to remove major role in MEDINFO 86. Dr. Donald tem in Rheumatology the brain cells causing seizures. His study of A. B. Lindberg, NLM Director, will chair the • AI/LEARN: An Interactive Rheumatology Teaching another neurological disorder-Parkinson's organizing committee; Dr. Arnold W. Pratt, Videodisk disease--resulted in the development of an im­ DCRT Director, will serve as government liai­ • Patient Management Simulation Illustrated with a Laservision Disc portant diagnostic tool. He and his associates son for the committee. • Interactive Video for Combat Trauma Training designed recording electrodes which they used Featuring equipment from major systems to • Myocardial Infarct Size Estimation by Microcomputer to find the part of the brain responsible for the microcomputers, the scientific demonstrations • AIDA: Applied Interactive Design of Application. tremor characteristic of parkinsonism. will be aimed at three audience sizes and deliv­ For a copy of the program or for additional Dr. Li was also a clinical professor in the de­ ered as large, cheater-style presentations, information, contact: MEDINFO 86, Secretar­ partment of neurosurgery at the George Wash­ smaller lectures, or as hands-on sessions. iat: Office of CME, George Washington Uni­ ington University School of Medicine. Born in The demonstrations will include: versity, 2300 K St., NW., Washington, DC Kwangchow, China, he received his M.D. de­ • RECONSIDER: A Diagnostic Prompting Aid 20037. 0 gree from the National Medical College of • The Johns Hopkins Oncology Clinical Information Shanghai. He also had an M.S. degree in System neuroanatomy and a Ph.D. in neurophysiology Shape-Up at Lunchtime from McGill University. He is survived by his wife, Julia Ying-Ru Weekend Sailing Sept. 27-28 The NIH Fitness Center has expanded its Li; three children, Claire Ming, Anne Ling, services to include a lunch-hour exercise class, and David; two stepchildren, Kai-Yu Wang, Explore the Bay in a 44' sailboat. Board m ALIVE' and William Wang; four brothers, and five Annapolis, Saturday, Sept. 27, at 8 a.m. After ALIVE is a real lunchtime pick-me-up with sisters. breakfast, set sail to St. Michaels, approxi­ a total body workout including warmup, isola­ mately 7 hours, and enjoy an evening in the tions, standing exercises, aerobics, floor exer­ historic town char James Michener wrote abour cises, cool-down and relaxarion. The co-ed class in Chesapeake. is held on the 14th floor of the Clinical Center On Sunday, cruise back to Annapolis. The on Tuesdays and Thursdays from 12: 15 to crew (you) helps the captain to navigate the 12:45. Bay. Cost is $127 per person and includes sail­ Cose for the 9-week session is $36. Coupons boat rental, two breakfasts, and two lunches. for five exercise class drop-ins ($15) are also Sign up at the Activities Desk, Bldg. 31, available. Rm. B 1W30 for this relaxing weekend. D Register for the class or purchase the drop-in coupons at the NIH Fitness Center (Bldg. T-39), R&W Activities Desk (Bldg. 31, Room BlW30), or the R&W Gift Shop in Bldg. 10, Workshop Planned on Catalysis B 1 level. For more information call the NIH Fitness The Medicinal Chemistry Study Section is Center, 496-TRIM. 0 sponsoring a workshop on "Biomimecic and Organometallic Catalysis" on Oct. 9 from 1 to 6 p.m. and October 10 from 8 a.m. to 5 p.m. R&W Business Office Relocating Edward Driscoll has been named chief of the Edito­ in the conference theater of the Crowne Plaza rial Operations Branch, OC, OD. A 1970 gradu­ Holiday Inn, 1750 Rockville Pike, Rockville, During October, November and December, ate of the University of Maryland, he majored in Md. The hotel can be reached by Metro and is the R&W Business Office will be relocated to journalism and English. He joined NIH the follow­ located at the Twinbrook stop on the Red Line. the R&W Gift Shop, Bldg. 38A, B 1 level. ing year as a staff writer on the NIH Record. After The workshop is open to anyone who wants Major renovations will occur in Bldg. 3l's 2 years with private industry, Mr. Driscoll returned to attend, space permitting. If you want to at­ gift shop resulting in a larger store area. The to NIH in 1976 as assistant branch chief, a posi­ tend, contact Dr. Ronald J. Dubois at score and Activities Desk will remain open dur­ tion he held until his recent promotion. 496-7107. 0 ing reconstruction. D Page 4 TheRecord September 23, 1986

Scholars-in-Residence Arrive at Fogarty Center Dr. Harold Scheraga, Todd professor of Dr. Carafoli's early interest in mitochondria chemistry at Cornell University, Ithaca, N.Y. led to his more recent work on calcium trans­ returned to the Fogarty Internacional Center to port systems, both in plasma membranes and resume his scholarship-in-residence. endoplasmic reticulum. He is one of the Prof. Scheraga is well-known for his work on world's experts on calcium transport systems. the physical chemistry of macromolecules, es­ He will be working in Dr. Claude Klee's pecially the physical chemistry of proteins and laboratory during his 5-month stay at the NIH. of aqueous solutions of macromolecules. In re­ He can be reached at the Stone House on cent years he has devoted his attention to the 496-3682. relationship between the amino acid sequence Dr. Akira Kobara, professor and chairman, of proteins and their three-dimensional department of biochemistry, Kobe University structure. School of Medicine, Japan, is returning to the During his second term as a Fogarty Scholar, NIH for a second term as a Fogarty Scholar. Dr. Scheraga will continue his association with He is one of the world's leading carbohydrate the Laboratory of Chemical Biology, NIDDK. biochemists and his work is of interest to many He can be reached in the Stone House where he laboratories at the NIH. He is best known for has an office, 496-873 5. his work on the enzymatic basis for blood types The first compact disc containing the National Li­ Dr. Roger Monier, former director, Divi­ in man, for structural studies on brary of Medicine's MEDLIN£ database is pre­ sion of Biological Sciences, CNRS, Paris, oligosaccharides and glycoproteins and for the sented to Dr. A. B. Lindberg, Director of the NLM France, who is presently chief of the Molecular development of many methods for structural ( r) by Philip E. Hixon, president of Cambridge Sci­ Oncology Laboratory at the Institut Gustav analysis of carbohydrates that are widely used entific Abstracts, which contributed the technology to Roussy in Villejuif, also returned to resume his throughout the world. produce MEDLIN£ on CD-ROM (Compact Disc­ Scholarship-in-Residence. During his 3-month stay at the NIH, Dr. Read Only Memory). The Cambridge firm will Dr. Monier has published extensively on the Kobara will work in Dr. Victor Ginsburg's lab­ market the new "Compact Cambridge/MEDLIN£" structure of SV40 and has made important con­ oratory and can be reached on 496-4161. product to researchers and librarians who may now tributions co our knowledge of its role in trans­ Dr. Vulimiri Ramalingaswami, director of use MEDLIN£ without going online. formation. Early in his career he purified trans­ the Indian Council of Medical Research in New fer RNA from E. coli in collaboration with Dr. Delhi, arrived recently to complete the second Paul Zamecnik, Massachusetts General Hospi­ term of his scholarship. tal. He was one of the first scientists to study He is known throughout India and the world the molecular properties of oncogenic viruses. for his outstanding contributions to experimen­ reached on 496-4161. He will be associated with the Laboratory of tal pathology, clinical nutrition and medical Dr. Leon Heppel, professor of biochemis­ Biology of Viruses, NIAID, where he will col­ education. try, molecular and cell biology at Cornell Uni­ laborate with his sponsor, Dr. Norman During his stay he will write a book on liver versity, arrived in September to complete his Salzman. He can be reached in his office at the disease in the tropics, which will cover nutri­ scholarship. During his tenure he will deliver Stone House, 496-8733. tional and toxic liver injuries coupled with lectures on: fura-2 and quantitative video fluo­ Dr. Chen Lu Tsou, professor at the Insti­ some syndromes of liver disease of uncertain rescence microscopy of individual cells and oxi­ tute of Biophysics, Academia Sinica, Beijing, etiology (origin) seen in the tropics. This work dative phosphorylation and photo arrived to begin his first term as a will involve discussions with scientists at the phosphorylation. Fogarty Scholar-in-Residence. His current in­ NIH. Professor Heppel is well-known for his terests concern structure-function activities in Dr. Ramalingaswami can be reached at his earlier work on polynucleoutides and in recent enzymes and he is using a variety of tech­ office in Stone House, 496-4161. years has been concerned with membrane bio­ niques, especially new chromophores and Dr. Abraham Patchornik, department of chemistry, particularly protein kinases depend­ fluorosphores, chemical modifications and de­ organic chemistry, Weizmann Institute of Sci­ ent on cyclic-AMP. tailed kinetic analyses, to investigate ence, Rehovot, Israel, arrived in September, to He will be associated with Dr. Claude Klee, conformational changes in proteins. In addi­ begin his first term as a Scholar. He will be in NCI, and will also have an office at Stone tion, he is also using x-ray crystallographic residence until January 1987. House where he can be reached on 496-4161. techniques to study enzyme conformation. He has been a consistent contributor in the Dr. Bruce Fraser, division of protein chem­ Dr. Tsou will be working in Dr. A. field of organic chemistry and its application to istry, CSRIO, in Parkville, Victoria, Australia, Schechcer's laboratory and will also have an of­ problems in biology. Much of his work has ad­ will be at NIH Sept. 15-28, for the sympo­ fice at Stone House, 496-2087. dressed the study of peptides and proteins, in­ sium on "Intermediate Filaments" which he or­ Dr. Ernesto Carafoli, professor of biochem­ cluding chemical synthesis of biologically ac­ ganized during his last term as a Scholar. istry at the Swiss Federal Institute of Technol­ tive peptides and selective cleavage and other Dr. Fraser's basic interest has been in fibrous ogy, Zurich, arrived for his second term as a chemical modifications of polypeptides. He has proteins. He has made major contributions to Fogarty Scholar-in-Residence. established a variety of uses of soluble polymers understanding the role of intermediate fila­ For many years, he has been at the forefront and polymeric reagents in the organic synthesis ments. His work produced publications in re­ of the biochemistry of ion transport systems of biomolecules. lated areas of neurobiology, epithelial differen­ and bioenergetics. His studies established the Dr. Patchornik will be associated with the tiation and myofilament morphology. existence of two different pathways for calcium Laboratory of Chemistry, NIDDK. He will also He also can be reached at the Stone House uptake and release from mitochonria. have an office at Stone House where he can be on 496-4161. D Page 5 TheRecord September 23, 1986

John T. Fitzgerald, GMLB, Retires After 30 Years Alexander M. Dolgun, FIC, Former Soviet Prisoner, Dies John T. Fitzgerald, chief, Heavy Equipment and Paving Section, Grounds Maintenance and Alexander M. Dolgun, 59, program analyst Landscaping Branch, Division of Engineering at the Fogarty International Center and former Services, recently retired after 30 years service Soviet prisoner, died of kidney failure Aug. 26. at NIH. He was responsible for the heavy Born in New York City, Mr. Dolgun accom­ equipment used for all grounds maintenance panied his parents and his sister to the USSR in work, including excavating for utility failures, 1934 when his father took a position as an en­ pavement cleaning and repairs, grading, plant­ gineer in the automotive industry in Moscow. ing of large trees, and snow removal. World War II prevented the family from re­ Mr. Fitzgerald is well-known and respected turning to the United States, and he was em­ for his quick response, expertise, thoroughness, ployed as a messenger by the American Em­ and pleasant personality while carrying our his bassy in Moscow, later becoming head of the responsibilities. He received several awards and files division of the consular section. One day acknowledgements over the years for his out­ in 1948, during his lunch hour, he was ab­ standing work efforts and dedication. In 1985 ducted on the street and thrown into a car by he was a recipient of the NIH Merit Award for two men. his work record and for participating in the es­ Mr. Dolgun's 1975 book, Alexander Do/gun's tablishment of a program for cleaning the Story: An American in the Gulag, details his ar­ ACRF parking garage. rest by the Soviet secret police on espionage Many NIH employees who may not have charges and subsequent years of torture under known his name will remember seeing him the Soviet prison system. He spent a year in driving the large dump trucks, loaders with 16 Mr. Fitzgerald receives a plaque showing the solitary confinement at Lefortov prison in ft. wide snow baskets, a backhoe, or street GMLB ID patch from his coworkers at his retire­ Moscow. sweeper. ment luncheon. When he continued to refuse to confess to A luncheon was held recently in Mr. espionage, he was transferred to Sukhanovka Fitzgerald's honor at Bish Thompson Restau­ prison, where he was beaten daily. Eventually rant in Bethesda to celebrate his "coming of He then accepted a position as engineering he was sent to a labor camp in Central Asia, age" and retirement. Many of his friends and helper with Fairfax Village performing many near one in which Alexander Solzhenitsyn, the family attended to wish him well in his next plumbing and electrical maintenance duties un­ subsequently famous Russian novelist, was be­ adventure, which includes visits to the til he came to NIH in 1956. His entire govern­ ing held. Danville, Va., area, other travels and extensive ment service was with NIH in the Grounds Although the two men did not meet until visiting with convalescent members of his Maintenance and Landscaping Branch. years later, Alexander Solzhenitsyn, in his book church. Mr. Fitzgerald lives in Washington, D.C. about the Gulag Archipelago, referred to Mr. Born on a farm in Java, Va., near Danville, with his wife and two of their seven children. Dolgun as the only man he ever heard of Mr. Fitzgerald grew up in Blairs, Va. He came He also has seven grandchildren. He is an ex­ emerging sane from interrogation in the to the Washington area in 1951 and worked for ceptionally active member of the Star of Bethle­ Sukhanovka prison. a contracting firm moving furniture until 1954 hem Church where he has been a deacon for 21 Mr. Dolgun was released from prison in when he worked for Hot Shoppes for a while. years. D 1956 under Nikita Khrushchev's general am­ nesty program and lived in Moscow for the next 15 years, where he was kept under surveil­ lance. Negotiations between the Soviet Govern­ NEI Grantee Chosen ment and the U.S. State Department enabled As MacArthur Fellow him to return to the United States in 1971. He settled in Potomac, Md., and came to work at the FIC in 1973 where he served as a focal An NEI grantee has received one of the point for coordinating cooperative activities MacArthur Foundation's coveted "genius with the Soviet Union and Eastern block award" fellowships. Dr. Robert M. Shapley, a countries. vision scientist and associate professor of neuro­ He is survived by his wife, a son, and a physiology at the Rockefeller University in sister. New York City, received $208,000. Dr. Shapley was cited by the foundation for Dr. Palmer W. Taylor of the University of discoveries which "have significantly altered the The "no-strings," 5-year fellowship grants, California, San Diego, talks to NIGMS pharma­ conventional understanding of how we see." He the foundation says, are to enable fellows to cology research associate Dr. Nancy Ostrowski at a has been a pioneer in using analytical tools of "focus their energies on the issues and problems poster session following his lecture on molecular per­ mathematical neurobiology to study visual cells they find important or critical." Awards range spectives on acetylcholinesterase and acetylcholine re­ and has raised new questions about the means from $164,000 to $300,000 depending on the ceptor function. Dr. Taylor, a member of the first by which information is encoded in the visual age of the recipient. D group of pharmacology associates who entered the pro­ pathway, the foundation said. Dr. Shapley was gram just over 20 years ago, has been an NIGMS one of 23 winners selected in this year's cycle of Everything has been figured out except hr;w to grantee since 19 71. foundation awards. live.-Jean-Paul Sartre Page 6 The Record September 2 3, 1986

Five Clinical Signs Flag Incorrect Diagnosis of MS DR. WALLACE

If it looks like multiple sclerosis-look Schiffer and Robert M. Herndon, and Kathleen (Continued from Page 1) again. M. Schwetz, R.N., of the University of Physicians can avoid incorrect diagnoses of Rochester (N. Y.) School of Medicine and Den­ asite was known. However, observations by Dr. multiple sclerosis by checking for five "red tistry, wrote the MS report. Their work was Wallace and his colleagues showed that the flags" that warn the disease may be something supported in part by the National Institute of parasite undergoes a sexual reproductive cycle other than MS, say four scientists writing in Neurological and Communicative Disorders in the cat, resulting in an oocyst stage, shed in the June 1986 Archives of Neurology. and Stroke--June Wyman 0 cat feces that is highly infectious to man and The authors report on 10 patients who met other animals. This work led to prevention and clinical criteria for MS but in fact had other FAES' Concerts Announced control of this important disease-­ neurologic problems, 3 of which were directly toxoplasmosis. treatable. Among the disorders mistaken for The Foundation for Advanced Education 1n Dr. Wallace came to the Bethesda campus in MS were spinal cord tumor, spinocerebellar de­ the Sciences will present eight concerts in its 1978 to serve for 4 years as NIAID's assistant generation, complicated migraine, and MS-like 1986-87 Chamber Music Series. scientific director. He then returned to the lab­ symptoms associated with a mental The dates for the concerts, to be held at 4 oratory to conduct research on epidemiology disturbance. p.m., Sundays in the Masur Auditorium are: and biology of mousepox (ectromelia). These About 10 percent of patients diagnosed as Oct. 5, Autyn String Quartet studies provided data and techniques (including having multiple sclerosis do not have the dis­ Nov. 2, Paula Robison, flute, and Eliot the development of a sensitive and specific ease, according ro recent estimates. These pa­ Fisk, guitar ELISA assay) that have improved surveillance tients may be treated with the wrong drugs or Nov. 23, Stephen Hough, piano and control of this disease when it occurs in erroneously entered into clinical trials of experi­ Dec. 7, New York Vocal Arts Ensemble laboratory mice. He also demonstrated that a mental drugs for MS, while their true illness Jan. 11, Lillian Kallir and Claude Frank, strain of vaccinia virus used to immunize goes untreated. duo-piano against mousepox was not effective in pre­ From their analysis, the authors derived five Mar. l, Salvatore Accardo, violin venting infection and transmission. clinical signs that should raise questions about Mar. 15, Peter Serkin, piano Following a 1-year assignment as senior pol­ an MS diagnosis: Mar. 29, Gabrieli Sering Quartet. icy analyst in the Office of Science and Tech­ • Absence of eye problems that are common Tickets are sold by subscription only and nology Policy, Executive Office of the Presi­ in MS patients such as optic nerve damage and cost $70 for the season. dent, Dr. Wallace returned to NIAID in 1984. oculomotor abnormalities. For further information, contact the Founda­ He served as acting deputy director of the In­ • Steady disease progression with no remis­ tion for Advanced Education in the Sciences, stitute, and the following year served as acting sions, especially in a younger patient. Al­ Bldg. 10, Rm. 2C207A, 496-7976. scientific director of the Institute's Intramural though 30 percent of MS patients become pro­ □ Research Program. At the time of his retire­ gressively disabled, progressive disease is far ment, he was the program's associate more common as a sign of degenerative diseases director. 0 and tumors. • Disease that is localized in a particular part of the nervous system, especially in the posterior fossa, at the craniocervical junction, or in the spinal cord. "Dissemination within Disoriented Patients Sought the nervous system is the rule in MS," the au­ By NINCDS Study Group thors point out. • Features not typical of MS such as normal Patients with spatial or geographical disori­ sensory and bladder function (sensory impair­ entation due to focal brain lesions or early-stage ment and bladder dysfunction are nearly uni­ progressive dementia are being sought for a versal in MS). Normal sensory function with study at the National Institute of Neurological advanced motor disability may indicate a vascu­ Marie Phillips, director of AARP's Minority Af­ and Communicative Disorders and Stroke. lar disease, as in three of the study's "not-MS" fairs Initiative (r), presents NIA EEO manager Prospective patients must be between 18 and cases. Also, progressive dementia, seizures, and Vivian Betton (/) with a cos ponsor's check as ( l to r) 75 years old, speak English as a first language, aphasias are unusual in MS and should suggest NIA deputy director Dr. Edward Schneider; Dr. and have had a recent neurological examina­ other diagnoses. T. Franklin Williams, NIA Director; and Dr. tion. Patients will undergo neuropsychological • Absence of abnormalities in the cerebro­ Herbert Nickens, DHHS Office of Minority Health, testing and, if physically able, they will be spinal fluid. Abnormal lgG antibody appears in look on. The NIA, AARP, and DHHS Office of asked to walk specified routes to test their abil­ the CSF fluid of up to 95 percent of patients Minority Health are cosponsors of the "Research on ity to follow a given course. The goal of the with MS. Aging Black Populations" workshop, which will be study is to clarify the cognitive processes in­ The authors suggest that their system also held September 25-26 in Con/ Rm. 10, Bldg. 31 volved in observing and remembering routes, has negative value: it can be used to spare MS beginning at 9 a.m. each day. landmarks, and maps. patients from extensive laboratory testing to Physicians who want to have patients consid­ confirm the diagnosis. When the MS diagnosis ered for admission should contact Dr. Jordan is clear on clinical grounds and there are no red One of the symptoms of an approaching nervous breakdown Grafman, NINCDS, Medical Neurology flags, neuroimaging studies and CSF analysis is the belief that one's work is terribly Branch, Bldg. 10, Rm. 4N246, Bethesda, MD are unnecessary, they suggest. important.-Ber,trand Russell 20892; telephone: (301) 496-5138. D Drs. Richard A. Rudick, Randolph B. Page 7 The Record September 23, 1986

NICHD Scientists Develop Computer Programs To Help Diabetics Control Disease at Home

By Leslie Fink measuring device. A numerical display on the New programs for personal computers may device cells the patient how much glucose the one day help diabetes patients manage their ill­ sample contains. ness with less day-co-day dependence on doc­ Currently, a patient keeps crack of chis infor­ tors and hospirals. By helping patients keep a mation by jotting it down in a logbook, which normal balance of blood glucose and insulin, he presents co his physician during office visits, researchers hope the technology will help chem about once every 3 months. "This results in an cackle the special problems chat face adolescent enormous amount of small bits of hand-written diabetes patients and diabetic women during information chat may be lose or misinter­ pregnancy. preted," says Dr. Rodbard. By entering the in­ Maintaining better control of glucose levels formation into a home computer, the patient in the blood may also help prevent blindness can instead prepare graphs and tables and reduce ocher long-term complications of summarizing his condition. diabetes chat can result from large swirigs in in­ Among the most important of these rabula­ sulin and glucose levels. cions, says of Dr. Rodbard, is the "glucose pro­ Dr. Anne (Ball) Sassaman has been named associate "Computers are becoming a part of all as­ file," an average of the patient's blood glucose director for extramural program at NIEHS, Re­ pects of our lives," says software developer Dr. at any time of day for the past week or two. search Triangle Park, N.C. As associate director she David Rodbard of NICHD. "We expect co see This profile helps docrors crack trends in how will have administrative responsibility for more than chat happen in medicine as well." the patient responds co his insulin doses. After a third of the NIEHS annual budget of more than In an article published in the January­ reviewing the profile, the doctor can type any $192 million. The Extramural Program is devoted February issue of Diabetes Care, Dr. Rodbard changes in the treatment regimen onto the pa­ to providing individual research grants to scientists and coworker Dr. Nat Pernick describe diabe­ tient's computer disk. at universities, colleges, and other non-profit research tes management programs for the IBM personal Although the computer programs are aimed institutions, grants to Environmental Health Sciences computer. The programs are '"user-friendly,' ultimately at the patient, Dr. Rodbard believes Centers and Marine and Freshwater Biomedical easy co learn and easy ro use," the report says. it will be some time before many of chem actu­ Centers, environmental health sciences training and Along with Mitchell Jaffe, Dr. Rodbard has ally use chis kind of software at home. This is career development grants and programs. Dr. also developed a second program for the Apple mainly because many physicians themselves Sassaman comes to NIEHS from the National Ile, Ile, and II+ computers. need general computer training and special Heart, Lung, and Blood Institute in Bethesda, "We have cried co make these programs rela­ training in these particular programs. Md., where she was chiefof the Blood Diseases tively easy," says Dr. Rodbard, "so people can "Physicians are actively educating themselves Branch in the Division of Blood Diseases and just put in the floppy disk, turn on the ma­ about computers. But right now, I would say 5 Resources. chine, and follow the instructions." co 10 percent of physicians are comfortable enough with computers co be enthusiastic 'Electronic Notebooks' about these new approaches co medical manage­ APPOINTMENT The programs serve as "electronic note­ ment," says Dr. Rodbard. So far, the programs (Continued from Page 1) books,'' recording daily blood glucose levels, are available only co physicians. insulin doses, and ocher information about the Memory Meters Tenn., and performed his internship and resi­ patient's health and diet. The software also dency at Yale University, New Haven, Conn. evaluates the recorded information and, based As the programs do become available co pa­ He began his biomedical research career as a on a physician's advice, can suggest adjust­ tients, they will be able co use the glucose pro­ Public Health Service clinical fellow and re­ ments in insulin dose. file and other analyses at home ro help them search fellow in metabolism at Yale University. The programs are a sequel co modern tech­ adjust insulin doses co maintain the normal The author of more than 200 scientific pa­ niques for measuring blood glucose at home, amount of glucose in the blood. Now being pers, Dr. Gorden has received numerous awards which a diabetes patient may do two ro four reseed in the clinic, blood glucose meters con­ for his work. In April 1986, Dr. Gorden was times a day. Most patients use a small, spring­ taining "memory" chips will transfer informa­ awarded the Distinguished Service Medal of the loaded lancet co prick a finger; they then dab a tion about blood glucose directly co the com­ Public Health Service for "outstanding scien­ drop of blood onto a chemically treated paper puter. These memory meters will bypass the tific reserach in diabetes and related endocrine strip and place it into an electronic glucose- need for entering dara into the computer by diseases and for excellent administrative direc­ hand. D tion of the NIDDK's intramural clinical program. Dr. Gorden will be leading a major research Male Hypertensives Needed institute with responsibility for conducting and Correction supporting research in diabetes, endocrinology The Laboratory of Neurosciences is currently and metabolic diseases; digestive diseases and seeking male volunteers over the age of 45 with Dr. Roland B. Scott is director of the nutrition; and kidney, urologic and hema­ a 10-year history of hypertension. Participants Howard University Center for Sickle Cell Disease, tologic diseases. muse be in good health and free of other medi­ not director of the Howard University College of NIDDK conducts both basic and clinical re­ cal problems. For information call (301) Medicine as was stated in the Aug. 12 issue of search at its facilities in Bethesda, Md. and 496-1272. 0 The NIH Record. □ Phoenix, Ariz. D Page 8 The Record September 23, 1986

Eminent Pioneers in History of Child Health Care Infantile Apnea: Topic Will Join in Pediatric Research Review at NIH Of Upcoming Conference A consensus development meeting on "Infan­ Dr. Albert Sabin, developer of the oral vac­ elude presentation of this year's Healthy tile Apnea and Home Monitoring" will be held cine against polio, Dr. Robert Haggerty, past Mothers, Healthy Babies Coalition awards. On Sept. 29 through Oct. 1 in the Clinical Cen­ president of the American Academy of Pediat­ behalf of the Surgeon General of the U.S. Pub­ ter's Masur Auditorium. rics, and several other pioneers in the history of lic Health Service, special recognition awards The conference will focus on whether on ap­ child health care will participate in a sympo­ will be presented to six members of the Coali­ nea (the brief cessation of breathing during sium, "Pediatric Research: A Century in Re­ tion whose programs excelled in promoting the sleep) is related to sudden infant death syn­ view," to be held Oct. 6th at 2 p.m. at the health of mothers and babies during 1985. drome and the usefulness of home apnea moni­ National Institutes of Health (NIH), Bldg 1, This year's Child Health Day takes place toring devices. Wilson Hall, in Bethesda, MD. during the first month of the NIH Centennial Apnea occurs in up to 50 percent of all pre­ The symposium, sponsored by the National year. The Child Health Day symposium is mature babies, and some 90 percent of all ba­ Institute of Child Health and Human Develop­ one of the first official NIH centennial com­ bies born at 28 or 29 weeks of pregnancy are ment, celebrates Child Health Day. Child memorative activities. It is open to all inter­ affected. Many infants are discharged from the Health Day is traditionally declared to be the ested individuals. No reservation is required. nursery on home monitoring but specific first Monday in October each year by Presiden­ For information call the NICHD Office of Re­ guidelines for its use and for its discontinuation tial Proclamation. search Reporting at (301) 496-5133. D have never been developed. Children in the United States have never A 14-member consensus panel has for the been healthier. Over the past 100 years, Clinical Immunology Conference past year looked at such questions as the effi­ biomedical research has drastically changed the Set for October in Baltimore cacy and safety of currently available home de­ nature and scope of pediatric care. Antibiotics vices for detecting infant apnea and what evi­ and preventive vaccines, developed since the The first Annual Conference of Clinical Im­ munology will be held Oct. 10-12 at the dence there is that home monitoring is effective turn of the century, have conquered many fatal in reducing infant mortality. childhood diseases. Major advances in the treat­ Hyatt Regency in Baltimore, Md. This is the charter meeting of the Society for Clinical Im­ Based on their findings, the panel will issue ment of premature and low birth-weight new­ a set of recommendations regarding the use of borns have significantly reduced infant mortal­ munology and is cosponsored by the American Association of Immunologists. home apnea monitoring. ity and morbidity. The conference will bring together pediatri­ Main topics will be AIDS and Soluble Regu­ In addition to Drs. Sabin and Haggerty, Dr. cians, neonatologists, family practitioners, epi­ lators of the Immune Response. Harry Gordon of the Albert Einstein College of demiologists, medical engineers, nurses, par­ Featured speakers will include Drs. Samuel Medicine, will share his experiences in the field ents and other members of the public. The Broder, Anthony Fauci, Robert Gallo, Edward of neonatology. Dr. Ruth Whittemore of the panel will hear 2 days of presentations by panel Goetz[, Robert A. Good, William Hazeltine, Yale University School of Medicine will discuss members and other experts and discussion from Brian Issel, Dan Longo, Thomas Merigan, progress made in the area of pediatric cardiol­ the audience. The panel is chaired by Dr. Frank Polk, Steven Rosenberg, Thomas ogy. She took care of the first Blalock-Taussig George A. Little, professor and chairman, de­ Waldman, and Joel Weinstock. shunt (blue baby) patient. Dr. Harold Harrison of maternal and child health at For more information, call Jack Wyatt at partment of Johns Hopkins University Hospital, who re­ Dartmouth Medical School in Hanover, N.H. 262-7902 or Dr. Noel Rose's office at (301) ceived the John Howland Award for his re­ The NIH has certified this conference as 955-3457. search on vitamin D, will discuss advances in □ meeting the criteria for 15 credit hours in cate­ nutrition and metabolic disorders in children. gory 1 of the physicians' recognition award of Dr. Judson Randolph, chief of surgery at Chil­ Retirement Planning Program Set the American Medical Association. dren's Hospital National Medical Center, will The Recruitment and Employee Benefits "Infantile Apnea and Home Monitoring" is relate progress in pediatric surgery and his ex­ Branch, DPM, is offering another "Retirement cosponsored by the National Institute of Child periences training under the founder of that Planning Program" for NIH employees on Oct. Health and Human Development, the National specialty, Dr. Robert Gross. 29 and 30. Heart, Lung, and Blood Institute, the Division The 2-hour symposium will be moderated by A personnel bulletin will be distributed of Maternal and Child Health in the Health pediatrician Sidney Gellis of the New England desk-to-desk giving more detailed Resources and Drug Administration and the Medical Center in Boston. information. D NIH Office of Medical Applications of The Child Health Day program will also in- U.S. GOVERNMENT PRINTING OFFICE 1986--491-282/20043 Research. D

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