Gregory M. Miller Ph.D

Curriculum Vitae Gregory M. Miller Ph.D.

Home Address 21 Curtiss Circle, Sudbury, Ma 01776 Cell: 508-930-8027; Home: 978-443-8280; [email protected]

Work Address Northeastern University, Mugar Hall 338, 360 Huntington Ave., Boston, MA 02115 Ph.: 617-373-6985; [email protected]; https://bouve.northeastern.edu/directory/greg-miller/ Education 1986 B.A. Psychology, Ithaca College, Ithaca NY 1991 M.A. Psychology-Neuropsychology, Queens College, City University of New York, NY 1993 Ph.D. Biomedical Sciences, Mount Sinai School of Medicine (MSSM), New York, NY Postdoctoral Training 1993/94 Endocrinology and Metabolism, MSSM 1994/97 Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA Faculty and Center Appointments 1995/97 Assistant in Biochemistry, Massachusetts General Hospital, Boston, MA 1997 Instructor in Medicine, Harvard Medical School, Boston, MA 1997/04 Instructor in Psychiatry, Harvard Medical School, Boston, MA 2005/12 Assistant Professor in Psychiatry, Harvard Medical School, Boston, MA 2012/14 Associate Professor in Psychiatry, Harvard Medical School, Boston, MA 2014/16 Visiting Associate Professor in Psychiatry, Harvard Medical School, Boston, MA 2014- Associate Professor in Pharmacology, Northeastern University, Boston MA 2014- Faculty, Center for Drug Discovery, Northeastern University, Boston MA 2016- Affiliated Faculty, Chemical Engineering, Northeastern University, Boston MA Administrative Leadership Positions/Appointments 1997/05 Manager, Div. of Neurochemistry, New England Primate Research Center, Harvard Medical School (NEPRC) 2006/08 Acting Chair, Division of Neurochemistry, NEPRC 2006/14 Director, Primate Genetics Core, NEPRC 2007/11 Director of Research and Compliance, Mouse Behavioral Laboratory, NEPRC 2012/14 Director, Summer Undergraduate and Summer Veterinary Training Programs, NEPRC 2016- Fellow, College on Problems of Drug Dependence (CPDD); see cpdd.org

TEACHING Classroom 1988, 1989 Psychology 101 (Undergraduate) City University of New York 1998 Substance Abuse ABS PS521 4th yr med.stud. Harvard Medical School 2014-2018 PHSC6300 Pharmaceutical Science Seminar Northeastern University 2014-2016 PHSC6984 Pharmaceutical Science Research Northeastern University 2015, 2017 PMCL6261 Pharmacology 2 Northeastern University 2015-2018 PHSC4502 Pharmacology/Med Chemistry 2 Northeastern University 2015-2017 PHSC 4501 Pharmacology/Med Chemistry 1 Northeastern University 2015 PHSC6984 Pharmaceutical Science Research Northeastern University 2015/16/17/18 PHSC6990; PHSC 4992; PHSC 4971 Thesis Northeastern University 2016/17/18 PHSC4850 Capstone supervision Northeastern University 2016/17/18 PHSC5976 Directed Study Northeastern University 2016/2018 PMCL6260 Pharmacology 1 Northeastern University 2016/2018 PMCL6262 Receptor Pharmacology Northeastern University 2017/2018 PHSC2650 Introduction to Health Science. Res. Northeastern University 2017/2018 PHMD 5600 Nutrition in Pharmacy Capstone Northeastern University

Assistantships, Lecture Series 1991-1992 Neuroendocrinology Mount Sinai School of Medicine, NY 2003, 2005 Cell Biology of Addiction Cold Spring Harbor, NY 2008 Psychiatry Residents/Neuroscience Beth Israel Deaconess Medical Center, MA

Teaching, Continuing Medical Education Courses 1997/08 CME: Neurobiology of Addiction (taught twice) Harvard Medical School, MA

Postdoctoral Fellows (under my mentorship) 1996/97 Joseph Pinzone, MD (Funded under Klibanski, PI) 1997/05 Richard De La Graza, PhD, Martin Goulet, PhD, Larry Gracz, PhD, Jeffrey Brown, PhD, Servet Yatin, PhD, Danqing Xiao, PhD, Christopher Vericco, PhD, Amy Jassen, PhD (Funded under Madras, PI) 2005/13 Guo-lin Chen, Ph.D., Zhihua Xie, Ph.D., Eric J. Vallender, Ph.D., Spencer Lynn, Ph.D. (Funded under Miller, PI)

Post-Bachelorette Research Technicians in my Lab that Transitioned to Graduate School 2001/04 Jacob Bendor->Rockefeller University with Paul Greengard; now at UCSF School of Medicine 2005/08 Sara Hakim-> The Albert Einstein College of Medicine; New Bioengineering TT faculty, Northeastern University 2006/08 Cassandra Priddy->Carnegie Mellon University; PhD candidate 2011/13 Caroline Sweeney->UMass Amherst, PhD candidate 2012/14 Lisa Ogawa->Yale University, PhD candidate

Undergraduate Student Cohorts 1997/13 Supervision and training of undergraduate summer students at NEPRC; dozens of students 2014/15 “Skunkworks” undergraduates in research at NU, 25 Freshman (self-sponsored, see student comments) 2015- Undergraduate students working in my lab at NU, see Funding Obtained for Student Mentees

SERVICE

Service, National Consortiums/Organizational Committees 2007/14 Genomic Banking Consortium, National Center for Research Resources, National Institute of Health 2007/14 Genetics Consortium, National Center for Research Resources, National Institute of Health 2008/16 Member, Chair and Senior Oversight, Publications Committee, College on Problems of Drug Dependence 2012/15 Member, Nominations Committee, College on Problems of Drug Dependence 2012/16 Elected Board Member, Board of Directors, College on Problems of Drug Dependence

Service, Foundation/Institute Study Section Activities 2007 Neurological Foundation of New Zealand 2007/08 Mount Sinai Center for Personalized Medicine, Bronfman Philanthropies, New York, NY (2) 2008 National Science Foundation, The Hague, Netherlands 2008 Netherlands Genomic Initiative 2008/10 National Science Foundation (NSF) (3) 2009 B/START, NIH 2010-15 ZDA1 GXM-A (09) 1, ZAA1 GG (21), ZRG1 NMB-A (02) S, ZRG1 MDCN-B(05), NIH 2011 INIA WEST, INIA STRESS, National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH (2) 2011 Health Research Council of New Zealand 2012 Harvard Catalyst, HMS 2013 The Leverhulme Trust, London, UK 2014 Boston College Ignites, Boston College, MA 2016 ZDA1 JXR-G (06), NIH

Service, Journal Reviewer Activities (reviewed manuscripts for >35 Journals) Editorial Roles: 2009 Genetic Tools for Understanding the Primate Genome, Methods 2009/12 Editor, News and Views Section, Drug and Alcohol Dependence

3 Service, Education of Patients and Service to the Community 2010/15 Member, Executive Committee, Community Connections Outreach on Substance Abuse, Sudbury, MA 2012 Organizer, “What were you thinking?” Presentation of the teen brain, Sudbury, MA 2015 Invited Speaker, Nu Rho Psi National Honor Society in Neuroscience, NU Chapter, Boston, MA 2015 Invited Speaker, Science Café, Franklin High School, Franklin, MA

Service, University Committees 2010/11 Chair, Search Committee - Genetics Faculty, NEPRC 2012 Member, Animal Records Information Technology Team, NEPRC 2013 Member, IACUC, NEPRC 2015 Honors Education Inquiry Group, NU 2015/17 Member, Graduate Committee, School of Pharmacy, NU 2015 Department Chair Search Committee, School of Pharmacy, NU 2015 Member, Bylaws Committee, School of Pharmacy, NU 2016/18 Chair, Bylaws Committee, School of Pharmacy, NU 2017/18 Member, Faculty Search Committees (3), School of Pharmacy, NU 2017/18 Presenter, Accepted Students Welcome Receptions (5), Bachelor of Science in Pharmaceutical Sciences (BSPS) recruitment, Bouve College of Health Sciences, NU 2017/18 Chair, Bouve Research Committee, Bouve College of Health Sciences, NU 2017/18 Member, Admissions Committee, School of Pharmacy, NU 2018 Renewed Term Member, Graduate Committee, School of Pharmacy, NU 2017/18 Bachelors Program in Pharmaceutical Sciences, Program Co-Director, School of Pharmacy, NU 2018 Organizer, Summer High School Student Lab Experience, School of Pharmacy, NU

Service, Students 2015/17 Ph.D. Qualifying Exam Committees, Department of Pharmaceutical Sciences, NU (8) Hiral Patel, Wen Zhang, Ziyi Xu, Khadijah Mohammad, Lipin Ji, Anthony Mannion, Lisa Fleischer, Katlynn Gwilt

2015/17 Ph.D. Thesis Committees, Department of Pharmaceutical Sciences, NU (5) Amirah Aly, Hiral Patel, Anthony Mannion, Charles Perry, Jimit Raghav

2015/17 Masters Thesis Mentor, Department of Pharmaceutical Sciences, NU (2) Anthony Mannion, Katlynn Gwilt

2015/18 Capstone Supervisor, School of Pharmacy, NU (46) Krista Vaccarella, Melissa Axelrod, Kevin Pao, Adam Cosby, Alessia Passannanti, Eric Chen, Stephanie Mortel, Xida Zou, Eun Choi, Danielle Connolly, MaryRose Maiullari, Michelle Wang, Janice Lin, Winnie Wan, Zoe Paiva, Mina Nayeri, Alexis Huang, Justin Kim, Shelby Song, Joyce Lo, Jihyun Park, Anh Ho, Paulina Phan, Avani Patel, Daniel Havkins, Emily Bitton, Elizabeth Marcus, Nadiyah Ali, Tejumade O Abeeb, Aki Lin, Cosette Yu, Kelsey Turner, Juri Chung, Kristine Zhang, Sharon Zhu, Allen Zhou, Jennie Chang, Amelia Kim, Benji Pun, Ryan Voelker, Tianyi Cao, MinFei Sun, Cindy Wu, Bertilla Liew, Julian Park, Solmi Park

2015- Ph.D Candidate Mentor, Department of Pharmaceutical Sciences, NU (3) Lisa Fleischer, Katlynn Gwilt, Anthony Mannion

2015/17 Directed Studies Mentor, Department of Pharmaceutical Sciences, NU (8) Kristianna Laccetti (G), Jianyu Shang (G), Shilan Dong (G), Rachana Deven Somaiya (G), Ronan Talty (U), Rachel Hoffing (U), Lisa Fleischer (G), Gregory Riley (G)

2016/17 Co-op Student Supervisor, Rachel Hoffing, Behavioral Neuroscience (BNS), Department of Psychology, NU

2017/18 Undergraduate Honors Thesis Supervisor, Vasileios Kreouzis, (BNS), Department of Psychology, NU; Rachel Hoffing (BNS), Department of Psychology, NU

Funding Obtained for Student Mentees while at Harvard Medical School: 2006 Irene and Eric Simon Brain Research Foundation to Liz Calder, undergraduate 2007/12 Six summer students funded through Department of Psychology Univ. of MA 2009 NIH R21 Supplement 022323-02S1 for Kate Sullivan, undergraduate 2011 CPDD Travel Award to Kiran Akila, foreign student from India

4 Funding Obtained for Student Mentees while at Northeastern University: 2015 NU Provost Undergraduate Research and Creative Endeavors, Paige Dickson ($2625) 2015 NU Undergraduate Honors Program Early Research Assistantships Nina Tamashunas, Kevin Freeman, Nicholas Mortillaro, Lauren Abbott ($1000 each) 2015 NU Scholars Independent Research Fellowships (SIRFs) Jared Ontko and Cindy Wu, Kristen Brown and Christine Boutros, Honors Scholars ($20,000) 2015 Nu Rho Psi Undergraduate Research Grant and Travel Award – 1 of 2 National Awards - Kristen Brown and Christine Boutros, Honors Scholars ($1000) 2015 Brain, Behavior and Chemistry Travel Award, Lisa Fliescher ($1000) 2017 NU Provost Undergraduate Research and Creative Endeavors, Vasileios Kreouzis ($3000) 2017 Nu Rho Psi Undergraduate Research Grant, Vasileios Kreouzis ($400) Travel award to attend and present at Society for Neuroscience Meeting 2017 2017 Matz Family Scholarship, Rachel Hoffing ($15,000) 2018 NU Provost Undergraduate Research and Creative Endeavors, Rachel Hoffing ($3000) 2018 NU Undergraduate Honors Program Early Research Assistantship, Neva Olliffe ($1000) Travel award to attend 2018 NCHC Annual Conference 2018 NU Scholars Independent Research Fellowships (SIRFs), Rachel Hoffing ($5000) 2018 NU Provost Undergraduate Research and Creative Endeavors, Nitali Thakur ($1000)

SCHOLARSHIP

Local Presentations (14) 2000- NEPRC (10), McLean Hospital, Belmont, MA (4), Massachusetts General Hospital, Boston, MA

Regional Presentations (5) 2008- Boston University Medical School, The Massachusetts College of Pharmacy and Health Sciences, Center for Drug Discovery, Northeastern University, Boston, MA

National Presentations (28) 1999/08 Oral presentations, Society for Neuroscience Annual Meetings (5) 2001/13 Oral presentations, College on Problems of Drug Dependence Annual Meetings (3) 2001/03 Oral presentation, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (2) 2006 Invited Presentation, Lundbeck Research USA Inc., Mahwah, NJ 2006 Invited Presentation, NCRR Workshops on the Rhesus Monkey Genome, NIH, Bethesda, MD 2006 Invited Presentation, Eli Lilly, Indianapolis, IN 2007 Invited Presentation, NCRR Workshops on the Rhesus Monkey Genome, NIH, Bethesda, MD 2008 Session 314, Session Chair, Society for Neuroscience Annual Meeting, Washington, DC 2008 Session Organizer/Invited Presentation, 41st Winter Conf. on Brain Research, Snowbird, UT 2008 Graduate Student-selected annual invited speaker, Oregon Health & Science University, Portland, OR 2008 Invited Talk, 116th Annual Meeting of the American Psychological Association 2009 Invited NIDA-sponsored Presentation, 42st Winter Conf. on Brain Res. Copper Mountain, CO 2009 Invited Presentation, Oregon National Primate Research Center, Beaverton, OR 2010 Session 16, Session Chair, College on Problems of Drug Dependence, Scottsdale, AZ 2011 Oral Comm. 2, Session Chair, College on Problems of Drug Dependence Hollywood, Florida 2011 Invited Presentation, Emory School of Medicine, Atlanta, GA 2013 Invited Presentation, Washington State University, Pullman, WA 2013 Invited Presentation, Sunovion Pharmaceuticals Inc., Marlborough, MA 2013 Invited Speaker/Session Chair, Amer. Col. Neuropsychopharm., Hollywood, Florida 2015 Invited Plenary Symposium Speaker, Brain, Biology and Chemistry, San Antonio, TX 2015 Invited Symposium Speaker/Chair, Amer. Soc. for Pharmacol. and Exp. Therap. Boston, MA

5 International Presentations (10) 2002 Oral presentation, College on Problems of Drug Dependence. Quebec, Canada 2005/12 Invited Speaker, Int. Conf. on Primate Genomics & Human Disease (3) 2010 Program Committee Member/Invited Session Speaker, 4th ICPGHD, Seattle, WA 2010/12 Session Chair, Int. Conf. on Primate Genomics & Human Disease 2010 Invited Presentation, 14th Biennial Int. Amine Oxidase Workshop, Edmonton, Alberta, Canada 2011 Invited Speaker, Target Meeting 1st World Drug Disc. Online Conference, targetmeeting.com 2012 Invited Speaker, Theme B, 10th Int. Catecholamine Symposium, Pacific Grove, California 2013 Invited Symposium Speaker, Dopamine 2013, Alghero, Italy

FUNDING Awarded Grants (NIH) 1991/94 NIDDK/ T32DK07645 Graduate Trainee, Terry Davies, MD (PI) 1994/95 NIDDK/ P32DK07028 Postdoctoral Trainee, Anne Klibanski, MD (PI) 1996/97 NIDDK/ NRSA F32DK09281, Postdoctoral NRSA, Miller (PI) 1997/06 NIDA/R01 11558, Miller (co-I), Bertha K. Madras (PI) 1998/08 NIDA/ R01 06303, Miller (co-I,1998/06), Madras (PI), Miller (PI,2006/08; $731,859) 2004/14 P51OD011103, NEPRC Base grant, Miller (Core Scientist), Jeffrey Flier (Dean, HMS, PI; ~$37M/yr) 2004/10 NIDA/ R01 016606, Miller (PI, $1,160,534) 2006/09 NIDA/ R21 021180, Miller (PI, $457,399) 2007/10 NIAAA/ R21 016194, Miller (PI, $443,823); NIAAA/ R21 016194-02S1, Miller (PI, $111,749) 2007/10 NIDA/R21 022323, Miller (PI, $472,788) 2008/11 NIMH/ R21 077995, Miller (PI, $429,413) 2009/11 NIDA/ R03 025802, Miller (PI, $173,500) 2009/13 NIAAA/ R21 016194-02S1, Miller (PI, $111,749) 2009 NIDA/ R21 022323-02S1, Miller (PI, $11,267) 2009/14 NIDA/ K02 025697, Independent Scientist Award, Miller (PI, $615,275) 2009/14 NIAAA/ R01 016828, Miller (co-I), Donna Platt (PI), $2.060,315 2012/14 NIDA/ 1R21DA034420, Miller (PI, $437,500) 2010/15 NIDA/ R21 030177, Miller (PI, $947,744) 2010/15 NIAAA/ 5R01AA19688, Miller (co-I), Eric Vallender (PI, mentee) $1,956,412

Competitive Institutional Awards 2005/07 NEPRC New Lab Start-up Package/Assistant Professor, Miller (PI, $100,000) 2007/09 NEPRC Pilot Project (competitive), Miller (PI, $80,000 Direct Cost) 2009/11 NEPRC Pilot Project (competitive), Miller (PI, $100,000 Direct Cost) 2010/11 NEPRC Pilot Project (competitive), Miller (PI, $40,000 Direct Cost) 2015- Unrestricted Faculty Research Funds, gift from HMS, Miller (PI, $187,000) 2016/17 Tier 1 Interdisciplinary Grant Application, NU, Brenhouse $50,000/Miller $0

Peer reviewed publications (72); h-index 35; i10-index 62; Citations 4020 PubMed: https://tinyurl.com/y88yl9vl Google Scholar: https://tinyurl.com/y7gwyf8w

1. Gibson MJ, Miller GM, Silverman A-J. Pulsatile luteinizing hormone secretion in normal female mice and hypogonadal female mice with preoptic area implants. Endocrinology 1991;128:965-71.

2. Wu TJ, Segal AZ, Miller GM, Gibson MJ, Silverman A-J. FOS expression in gonadotropin-releasing hormone neurons: enhancement by steroid treatment and mating. Endocrinology 1992;131:2045-50.

6 3. Silverman A-J, Roberts JL, Dong KW, Miller GM, Gibson MJ. Intrahypothalamic injection of a cell line secreting gonadotropin-releasing hormone results in cellular differentiation and reversal of hypogonadism in mutant mice. Proceedings of the National Academy of Sciences (USA) 1992;89:10668-72. PMCID: PMC50402

4. Miller GM, Silverman A-J, Roberts JL, Dong KW, Gibson MJ. Functional assessment of intrahypothalamic implants of immortalized gonadotropin-releasing hormone secreting cells in female hypogonadal mice. Cell Transplantation 1993;2(3):251-7.

5. Miller GM, Gibson MJ. Opioidergic modulation of N-methyl-D,L-aspartic acid (NMA)-stimulated LH release in young adult but not older male mice. Neuroendocrinology 1994;59:277-84.

6. Miller GM, Silverman A-J, Gibson MJ. Neuromodulation of transplanted GnRH neurons in male and female hypogonadal mice with preoptic area brain grafts. Biology of Reproduction 1995;52:572-83.

7. Miller GM, Alexander JM, Bikkal HA, Katznelson L, Zervas NT, Klibanski A. Somatostatin receptor subtype gene expression in pituitary adenomas. Journal of Clinical Endocrinology and Metabolism 1995;80:1386-92.

8. Miller GM, Alexander JM, Klibanski A. Gonadotropin-releasing hormone mRNA expression in gonadotroph tumors and normal human pituitary. Journal of Clinical Endocrinology and Metabolism 1996;81:80-3.

9. Gibson MJ, Wu TJ, Miller GM, Silverman A-J. What nature's knockout teaches us about GnRH Activity: Hypogonadal mice and neuronal grafts. Hormones and Behavior 1997;31(3):212-220.

10. Madras BK, Miller GM, Meltzer PC, Brownell A-L, Fischman AJ. Molecular and regional targets of cocaine in primate brain: liberation from prosaic views. Addiction Biology 2000;5:351-9.

11 Miller GM, De La Garza R, Novak MA, Madras BK. Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles in primates: Implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disorders. Molecular Psychiatry 2001;6:50-8.

12 Miller GM, Yatin SM, De La Garza R, Goulet M, Madras BK. Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Molecular Brain Reserach 2001;87(1):124-43.

13 Goulet M, Miller GM, Bendor J, Liu S, Meltzer PC, Madras BK. Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates? Synapse 2001;42:129-40.

14 Miller GM, Madras BK. Polymorphisms in the 3’-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression. Molecular Psychiatry 2002;7(1):44-55.

15 Madras BK, Miller GM, Fischman AJ. The dopamine transporter: Relevance to attention deficit hyperactivity disorder (ADHD). Behavioral Brain Research 2002;130(1-2):57-63.

16 Yatin SM, Miller GM, Norton C, Madras BK. Dopamine transporter-dependent and –independent c-fos induction by dopamine transporter substrates and inhibitors. Synapse 2002;45(1):52-65.

17 Madras BK, Fahey MA, Miller GM, De La Garza R, Spealman RD, Meltzer PC, George SR, O’Dowd BF, Bonad AA, Livni E, Fischman AJ. Non-amine based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors. European Journal of Pharmacology 2003;479:41-51

7 18 Miller GM, Bendor J, Tiefenbacher S, Yang H, Novak M, Madras BK. A Mu-opioid receptor single nucleotide polymorphism in rhesus monkey: Association with stress response and aggression. Molecular Psychiatry 2004;9(1):99-108.

19 Madras BK, Miller GM, Yatin SM. Dopamine and norepinephrine transporter-dependent immediate early gene production in vitro: new insights into psychostimulant-induced presynaptic neuroadaptation. Journal of Neuroscience Methods 2005;143(1):69-78.

20 Madras BK, Miller GM, Fischman AJ. The Dopamine Transporter and Attention Deficit Hyperactivity Disorder (ADHD). Biological Psychiatry 2005;57(11):1397-1409.

21 Jassen AK, Brown JM, Panas HN, Miller GM, Xiao D, Madras BK. Variants of the primate vesicular monoamine transporter-2. Molecular Brain Research 2005;139(2):251-7.

22 Yatin SM, Miller GM, Madras BK. Dopamine and norepinephrine transporter-dependent c-Fos production in vitro: relevance to neuroadaptation. Journal of Neuroscience Methods 2005;143(1):69-78.

23. Miller GM, Verrico CD, Jassen A, Konar M, Yang H, Panas H, Bahn M, Johnson R and Madras BK. Primate trace amine receptor 1 modulation by the dopamine transporter. Journal of Pharmacology and Experimental Therapeutics 2005;313(3):983-994.

24. Xiao D, Miller GM, Jassen AK, Westmoreland SV, Pauley D, Madras BK. Ephrin/Eph Receptor Expression in Brain of Adult Nonhuman Primates: Implications for Neuroadaption. Molecular Brain Research, 2006;1067(1):67-77.

25. Jassen AK, Yang H, Miller GM, Calder E, Madras BK. Receptor regulation of axon guidance molecule gene expression. Molecular Pharmacology 2006;70(1):71-7.

26. Kumar, R, Orsoni1 S, Norman1 L, Tirado1 G, Verma1 AS, Staprans S, Miller G, Buch SJ, Kumar A. Morphine Addiction Causes Pronounced Virus Replication in Cerebral Compartment and Accelerated Onset of AIDS in SIV/SHIV-infected Indian Rhesus Macaques. Virology 2006;354(1):192-206.

27. Chen GL, Novak MA, Hakim S, Xie Z, Miller GM. Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression. Molecular Psychiatry 2006;11(10):914-28.

28. Madras BK, Xie Z, Lin Z, Jassen AJ, Panas H, Lynch L, Johnson RS, Livni E, Spencer TJ, Bonab AA, Miller GM, Fischman AJ. Modafinil Occupies Dopamine and Norepinephrine Transporters in vivo and Modulates the Transporters and Trace Amine Activity in vitro. Journal of Pharmacology and Experimental Therapeutics 2006;319(2):561-9.

29. Newman RM, Hall L, Connole M, Chen G-l, Sato S, Yuste E, Diehl W, Hunter E, Kaur A, Miller GM and Johnson WE. Balancing selection and the evolution of functional polymorphism in old world monkey trim5alpha. Proceeding of the National Academy of Science (USA), 2006;103(50):19134-9. PMCID: PMC1679755

30. Verrico CD, Miller GM, Madras BK. MDMA (Ecstasy) and Human Dopamine, Norepinephrine and Serotonin Transporters: Implications for MDMA-Induced Neurotoxicity and Treatment. Psychopharmacology 2007;189(4):489-503.

31. Xie, Z, Westmoreland S, Bahn ME, Chen G-L, Yang H, Vallender E, Yao WD, Madras BK, Miller GM. Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and 8 attenuation by the D2 autoreceptor in vitro. Journal of Pharmacology and Experimental Therapeutics 2007;321(1):116-27.

32. Xie Z and Miller GM. Trace Amine-Associated Receptor 1 is a Modulator of the Dopamine Transporter. Journal of Pharmacology and Experimental Therapeutics 2007;321(1):128-36.

33. Zhang JP, Vinuela A, Neely MH, Grant SG, Miller GM, Isacson O, Caron MG, Yao WD. Inhibition of the Dopamine D1 Receptor Signaling by PSD-95. Journal of Biological Chemistry. 2007;282(21):15778-89. PMCID: PMC2649122

34. Chen GL and Miller GM. Rhesus Monkey Tryptophan Hydroxylase-2 Coding Region Haplotypes Affect mRNA Stability. Neuroscience 2008;155(2):485-91. PMCID: PMC2644555

35. Chen G-L, Vallender EJ, Miller GM. Functional Characterization of the Human TPH2 5' Regulatory Region: Untranslated Region and Polymorphisms Modulate Gene Expression In Vitro. Human Genetics 2008;122(6):645- 57. PMCID: PMC2734478

36. Lee AS, Gutierrez-Arcelus M, Perry GH, Vallender EJ, Johnson WE, Miller GM, Korbel JO and Lee C. Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studies. Human Molecular Genetics 2008; 17(8):1127-36.

37. Xie Z and Miller GM. -Phenylethylamine Alters Monoamine Transporter Function via Trace Amine- Associated Receptor 1: Implication for Modulatory Roles of Trace Amines in Brain. Journal of Pharmacology and Experimental Therapeutics 2008;325(2):617-628.

38. Xie Z, Westmoreland SV, Miller GM. Modulation of Monoamine Transporters by Common Biogenic Amines via Trace Amine-Associated Receptor 1 and Monoamine Autoreceptors in HEK293 Cells and Brain Synaptosomes. Journal of Pharmacology and Experimental Therapeutics 2008;325(2):629-640.

39. Vallender EJ, Priddy CM, Chen G-L, Miller GM. Human Expression Variation in the mu Opioid Receptor is Paralleled in the Rhesus Macaque. Behavior Genetics 2008;38(4):390-395.

40. Vallender EJ, Priddy CM, Hakim S, Yang H, Chen G-L, Miller GM. Functional variation in the 3’ UTR of the serotonin transporter in human and rhesus macaque. Genes, Brain and Behavior 2008;7(6):690-7.

41. Xie Z, Vallender EJ, Yu N, Kirstein S, Yang H, Bahn M, Westmoreland SV, Miller GM. Cloning, expression and functional analysis of rhesus monkey trace amine-associated receptor 6: Evidence for lack of monoaminergic association. Journal of Neuroscience Research 2008;86(15):3435-46. PMCID: PMC2644554

42. Verrico CD, Lynch L, Fahey MA, Fryer A-K, Miller GM and Madras BK. MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitor. Journal of Psychopharmacology 2008;22(2):187-202. 43. Vallender EJ, Lynch L, Novak MA, Miller GM. Polymorphisms in the 3' UTR of the serotonin transporter are associated with cognitive flexibility in rhesus macaques. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2009;150B(4):467-75. PMCID: PMC2702718

44. Chen GL and Miller GM. 5'-Untranslated Region of the Tryptophan hydroxylase-2 Gene Harbors an Asymmetric Bidirectional Promoter but not Internal Ribosome Entry Site in vitro. Gene 2009;435(1-2):53-62. PMCID: PMC2670360

9 45. Xie Z and Miller GM. A Receptor Mechanism for Methamphetamine Action in Dopamine Transporter Regulation in Brain. Journal of Pharmacology and Experimental Therapeutics 2009;330(1):316-25. PMCID: PMC2700171

46. Ferguson B, Capitanio J, Folks T, Hotchkiss C, Johnson Z, Kean L, Kubisch HM, Lank S, Lyons L, Miller GM, Nylander J, O'Connor D, Vallender EJ, Wiseman R. Resource brief: the National Non-Human Primate DNA Bank. Methods. 2009;49(1):3-4. PMCID: PMC3172814

47. Kanthaswamy S, Capitanio JP, Dubay CJ, Ferguson B, Folks T, Ha JC, Hotchkiss CE, Johnson ZP, Katze MG, Kean LS, Kubisch HM, Lank S, Lyons LA, Miller GM, Nylander J, O’Connor DH, Palermo RE, Smith DG, Vallender EJ, Wiseman RW, Rogers J. Resources for Genetic Management and Genomics Research on Non-Human Primates at the National Primate Research Centers (NPRCs). Journal of Medical Primatology 2009;38 Suppl 1:17-23.

48. Xie Z and Miller GM. Trace amine-associated receptor 1 as a monoaminergic modulator in brain. Biochemical Pharmacology 2009 78(9);1095-04. Review. PMCID: PMC2748138

49. Chen GL, Novak MA, Meyer JS, Kelly BJ, Vallender EJ, Miller GM. The Effect of Rearing Experience and TPH2 Genotype on HPA Axis Function and Aggression in Rhesus Monkeys: a Retrospective Analysis. Hormones and Behavior 2010;57(2):184-91. PMCID: PMC2815197

50. Vallender EJ, Ruedi-Bettschen D, Miller GM*, Platt DM. A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys. Drug and Alcohol Dependence 2010;109(1-3):252-6. PMCID: PMC2875311 *Corresponding author

51. Vallender EJ, Xie Z, Westmoreland SV, Miller GM. Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs. BMC Evolutionary Biology 2010;10:51. PMCID: PMC2838891

52. Chen GL, Novak MA, Meyer JS, Kelly BJ, Vallender EJ, Miller GM. TPH2 5'- and 3'-Regulatory Polymorphisms Are Differentially Associated with HPA Axis Function and Self-Injurious Behavior in Rhesus Monkeys. Genes, Brain and Behavior 2010;9(3):335-347. PMCID: PMC2990963

53. *Panas H, *Lynch L, Vallender E, Xie Z, Chen GL, Lynn S, Scanlan T and Miller GM. Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice. Journal of Neuroscience Research 2010;88(9):1962-9. PMC Journal - In Process *Shared first-authorship; both are Research Assistant III’s in my lab.

54. Miller GM. The Emerging Role of Trace Amine Associated Receptor 1 in the Functional Regulation of Monoamine Transporters and Dopaminergic Activity. Journal of Neurochemistry 2011;116(2):164-76. PMCID: PMC3005101 Review, contains new data not published elsewhere.

55. Karmacharya R, Lynn SK, Demarco S, Ortiz A, Wang X, Lundy MY, Xie Z, Cohen BM, Miller GM, Buttner EA. Behavioral effects of clozapine: Involvement of trace amine pathways in C. elegans and M. musculus. Brain Research 2011, Jun 1;1393:91-9. PMCID: PMC3107707

10 56. Westmoreland SV, Annamalai L, Lentz MR, Ratai EM, Assaf B, Boisvert K, Huynh T, Vallender EJ, Miller GM, Madras BK, Gonzalez RG. Growth associated protein-43 and Ephrin B3 Induction in the Brain of Adult SIV-infected Rhesus Macaques. Journal of Neurovirology 17(5):455-68. 2011.

57. Lewin AH, Miller GM, Gilmour B. Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class. Bioorganic & Medicinal Chemistry Dec 1;19(23):7044-8, 2011. PMCID: PMC3236098

58. Achat-Mendes C, Lynch LJ, Sullivan KA, Vallender EJ, Miller GM. Augmentation of methamphetamine- induced behaviors in transgenic mice lacking the trace amine-associated receptor 1. Pharmacol Biochem Behav. Apr;101(2):201-207, 2012. PMCID: PMC3288391

59. Chen G-L and Miller GM. Advances in Tryptophan Hydroxylase-2 Gene Expression Regulation: New Insights into Serotonin-Stress Interaction and Clinical Implications. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. Mar;159B(2):152-171, 2012

60. Miller GM. Avenues for the Development of Therapeutics That Target Trace Amine Associated Receptor 1 (TAAR1). Journal of Medicinal Chemistry, Mar 8;55(5):1809-1814, 2012. PMCID: PMC3618978

61. Panas MW, Xie Z, Panas HN, Hoener MC, Vallender EJ, Miller GM. Trace Amine Associated Receptor 1 Signaling in Activated Lymphocytes. Journal of Neuroimmune Pharmacology Dec;7(4):866-76, 2012

62. Chen GL, Miller GM. Tryptophan Hydroxylase-2: An Emerging Therapeutic Target for Stress Disorders. Biochem Pharmacol. 85(9):1227-33, 2013.

63. Chen GL, Miller GM. Extensive Alternative Splicing of the Repressor Element Silencing Transcription Factor Linked to Cancer. PLOSOne 2013 Apr 16;8(4):e62217. PMCID: PMC3628349

64. Lynch J*, Sullivan KA*, Vallender EJ, Rowlett JK, Platt DM, Miller GM. Trace Amine Associated Receptor 1 Modulates Behavioral Effects of Ethanol. Substance Abuse: Research and Treatment. 2013, Jun 4;7:117-126. * both are Research Assistant III’s in my lab.

65. Vallender EJ and Miller GM. Non-Human Primate Models in the Genomic Era: A Paradigm Shift. Institute for Laboratory Animal Research Journal 2013 54: 154-165.

66. Goswami DB, Ogawa LM, Ward JM, Miller GM, Vallender EJ. Large-scale polymorphism discovery in macaque G-protein coupled receptors. BMC Genomics 2013, 14:703.

67. Cho JA, Zhang X, Miller GM, Lencer WI, Nery FC. 4-phenylbutyrate attenuates the ER Stress Response and Decreases Cyclic AMP Accumulation in DYT1 Dystonia Cell Models. PLOSOne 2014, Nov 7;9(11):e110086. PMCID: PMC4224384

68. Yasuda K, Oh K, Ren B, Tickle TL, Franzosa EA., Wachtman LM., Miller AD, Westmoreland SV, Mansfield KG, Vallender EJ, Miller GM, Rowlett JK., Gevers D, Huttenhower C. Morgan XC. Biogeography of the intestinal mucosal and lumenal microbiome in the rhesus macaque. Cell Host and Microbe 2015, 17(3):385-91.

69. Grandy DK, Miller GM, Li J-X. “TAARgeting Addiction” The Alamo Bears Witness to Another Revolution. An Overview of the Plenary Symposium of the 2015 Behavior, Biology and Chemistry Conference. Drug and Alcohol Dependence, 2016 Feb 1;159:9-16.

11 70. Sweeney CG, Rando JM, Panas HN, Miller GM, Platt DM, Vallender EJ. Convergent Balancing Selection on the Mu-Opioid Receptor in Primates. Molecular Biology and Evolution, 2017 Mol Biol Evol. 2017 Jul 1;34(7):1629-1643.

71. Chandlera CM, Follett ME, Porterd NJ, Liangd KY, Vallender EJ, Miller GM, Rowlett JK, Platt DM. Persistent negative effects of alcohol drinking on aspects of novelty-seeking behavior in rhesus macaques. Alcohol, 2017 63:19-26. 72. Chen G-L, Ma Q, Goswami D, Shang J, Miller GM. Modulation of Nuclear REST by Alternative Splicing: A Potential Therapeutic Target for Huntington’s Disease. Journal of Cellular and Molecular Medicine, 2017, J Cell Mol Med. 2017 May 19.

Non-peer reviewed scientific or medical publications/materials in print or other media

1. Madras B, Miller GM, De La Garza R, Dougherty DD, Bonab AA, Spencer TJ, Rauch SL, Fischman AJ. Brain Imaging of the dopamine transporter in ADHD. 6th International World Congress for Biomedical.Sciences 2000;113. PMC Journal - In Process

2. Gibson MJ, Saitoh Y, Miller GM, Silverman A-J. Functional GnRH neuronal transplants in the hypogonadal mouse. In: Crowley WF Jr, Conn PM, editors. Modes of Action of GnRH and GnRH analogs. New York, New York: Springer-Verlag, 1992:144-57.

3. Miller GM, Zhang X, Klibanski A. Pituitary tumors: future perspectives. In: Kovacs, K. editors. Diagnosis and management of pituitary tumors. Totowa, New Jersey: Humana Press Inc., 2001, pgs 462-6.

4. Miller GM and Madras BK. Genetic Variations and Phenotypic Associations Common to Rhesus Monkeys and Humans. In: SA Wolfe-Coote, editor. The Laboratory Primate. Tygerberg, South Africa: Medical Research Council of South Africa, Elsevier Publishing Inc., 2005.

5. Ferguson B, Miller GM. Genetic tools for understanding the primate genome. Methods 2009;49(1):1-2. Editorial.

Thesis

1. Miller GM. Neuromodulation of luteinizing hormone secretion in the mouse [dissertation]. New York (NY): City Univ. New York, 1993.