The 37th Annual Meeting of the Japanese Society for Biomedical Mass Spectrometry

Program

October 25th(Thu) – 26th(Fri), 2012

Aichi Industry & Labor Center (WINC AICHI), 5F Small Hall and 6F Exhibition Space 4-38 Meieki-4, Nakamura-ku, -city, Aichi, Japan

Akira Ishii, MD. , Ph.D.

President of the 37th Annual Meeting of the Japanese Society for Biomedical Mass Spectrometry

Department of Legal Medicine and Bioethics Nagoya University Graduate School of Medicine

65 Tsurumai-cho, Showa-ku, Nagoya-city, Aichi, Japan Tel: +81-52-744-2117 Fax: +81-52-744-2121 E-mail: [email protected]

Time Schedule

October 25 (Thursday) 9:25- 9:30 Opening Remarks 9:30- 11:30 Symposium 1 11:40- 12:20 Luncheon Seminar / Board Meeting 12:20- 12:50 JSBMS General Meeting 13:00- 14:00 Poster Presentation 14:00- 15:00 Oral Session 1 15:10- 17:10 Symposium 2 17:30- 19:30 Banquet

October 26 (Friday) 9:10-10:40 Symposium 3 10:50-11:50 Invited lecture 12:00-12:40 Luncheon Seminar 12:50-13:20 Isamu Matsumoto” Prize lecture 13:20-14:40 Oral Session 2 14:50-15:50 Technical workshop1 15:50-16:35 Technical workshop2 16:35 Closing Remarks

Program September 25(Thursday) 9:25- 9:30 Opening Remarks (Akira Ishii) 9:30- 11:30 Symposium 1 Organizer: Fumio Nomura (Chiba University), Toyofumi Nakanishi ( Medical College)

S1-1 The ”ABC” of proteomics focused on post-translational modifications. Naoshi Dohmae1 1RIKEN Advanced Science Institute

S1-2 Identifications of amyloidogenic proteins in FFPE tissue sections of amyloidoses and traceabilities of drugs/medicine histories in sliced hair sections by MALDI-imaging Toyofumi Nakanishi Department of Clinical and Laboratory Medicine, Osaka Medical College

S1-3 Quantitative proteomics of serum for diagnostic applications. Mamoru Satoh1,2,4, Yusuke Kawashima3, Kazuyuki Sogawa1,2, Tatsuya Saito3, Sayaka Kado4, Fumio Nomura1,2 1Clinical Proteomics Research Center, Chiba University Hospital 2Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University 3Center for Disease Proteomics, School of Science, Kitasato University 4Chemical Analysis Center, Chiba University

S1-4 In vitro diagnostics - development to medical reimbursement Masahiro Hashiguchi Medical and Biologocal Laboratories Co.,LTD. Sales and Marketing Division

11:40- 12:20 Luncheon Seminar / Board Meeting Application of a triple quadrupole mass spectrometer on the forensic medicine Toshikazu Minohata (Shimadzu Corporation)

12:20- 12:50 JSBMS General Meeting 13:00- 14:00 Poster Presentation

P-1 Apolipoprotein E Serotyping Motoi Nishimura1,2,3, Satomi Nishimura1, Mamoru Satoh1,3, Syoko Kakinuma1, Kenichi Sato2, Setsu Sawai1,2, Sayaka Kado4, Yoshio Kodera3,5, Fumio Nomura1,2,3 1Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University 2Division of Laboratory Medicine and Clinical Genetics, Chiba University Hospital 3Clinical Proteomics Research Center, Chiba University Hospital 4Chemical Analysis Center, Chiba University 5Laboratory of Biomolecular Dynamics, Department of Physics, School of Science, Kitasato University

P-2 Search for novel lung cancer biomarkers by proteomic analysis of exosomal membrane Takuya Yamashita1,2,3, Kazuya Nagano2, So-ichiro Kanasaki2,3, Yuka Maeda2,3, Hiromi Nabeshi2,3, Tomoaki Yoshikawa2,3,Yasuo Yoshioka2,3,4, Masaki Inoue2, Yasuhiro Abe2, Haruhiko Kamada2,4, Fumiyo Kasuya1, Yasuo Tsutsumi2,3,4,Shin-ichi Tsunoda2,3,4 1 Faculty of Pharmaceutical Sciences, Kobegakuin University. 2 National Institute of Biomedical Innovation. 3 Graduate School of Pharmaceutical Science, Osaka University. 4 The Center for Advanced Medical Engineering and Informatics, Osaka University.

P-3 Calculation of O-glycosylation site occupancy based on the peak intensity of peptide/glycopeptide ions in MALDI mass spectrum Yoshinao Wada、Machiko Kadoya Osaka Medical Center and Research Institute for Maternal and Child Health

P-4 Optimization of rapid identification of microorganism by MALDI-TOFMS and its application for diagnosis of severe infectious disease Toyofumi Nakanishi1, Tomohiro Higashiyama2, Yumiko Matsuyama3, Takayuki Takubo1 1Department of Clinical and Laboratory Medicine, Osaka Medical College 2Central Clinical Laboratory, Osaka Medical College Hospital 3Technical Support Center, Bruker Daltonics K. K.

P-5 Discrimination between methicillin-sensitive and methicillin-resistant Staphylococcus aureus by MALDI-TOF mass spectrometry Kazuyuki Sogawa1, Masaharu Watanabe2, Fumie Iida1,Syunsuke Segawa2, Akiko Miyabe2, Syota Murata2, Tomoko Saito2, and Fumio Nomura1,2,3 1Clinical Proteomics Research Center, Chiba University Hospital 2Department of Clinical Laboratory, Chiba University Hospital 3Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University

P-6 Exploring of blood markers in early stages of chronic renal failure in rat Toshihiro Kobayashi1, Yuriko Matsumura1, Atsuo Iwasawa1, Toshihiko Ozawa1, Toshiaki Kamachi1, Tatsuya Fujisawa2, Kouichi Fujiwara2, Masahiro Kohno1, Noriaki Tanaka2 1Tokyo Institute of Technology 2Tanaka-Kitanoda Hospital

P-7 Characterization of phase II metabolism of tetrahydrocorticosteroids in human liver by LC/MS Kuniko Mitamura1, Mami Kamibayashi1, Kanta Sato1, Sachi Fujioka1, Masataka Nakajima1, Rika Satoh (née Okihara)2, Takashi Iida2, Shigeo Ikegawa1 1 Faculty of Pharmaceutical Sciences, Kinki University 2 College of Humanities & Sciences, Nihon University

P-8 Analysis of Steroid Hormones in Human Saliva and Serum using Column-switching Ultra-fast LC/MS/MS Yukiko Hirabayashi 1, Takashi Shinagawa 2, Joji Suzuki 2, Toshio Kaji 2 1 Central Research Laboratory, Hitachi, Ltd. 2 Hitachi Hospital, Hitachi, Ltd.

P-9 TBARS does not reflect the level of phosphatidylcholine hydroperoxides in oxidized lipoproteins Shu-Ping Hui1, Toshihiro Sakurai1, Shigeki Jin1, Hirotoshi Fuda1, Seiji Takeda1, Takao Kurosawa2, Hitoshi Chiba1 1Faculty of Health Sciences, Hokkaido University, Japan 2Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan

P-10 Simultaneous analysis of 16 plasma isoflavone metabolites in 5 age-matched young women by liquid chromatography tandem mass spectrometry Kaori Hosoda1, Akitomo Yokokawa2, Hiromi Shibasaki2, Takashi Furuta2, Kazuo Ishii1 1Kyorin University, School of Health Sciences 2Tokyo University of Pharmacy and Life Sciences, School of Pharmacy

P-11 Determination of pyrimidine metabolites for inborn error of pirimidine metabolism by UPLC-MS/MS Yasuhiro Maeda1, Ayumi Kato1, Tetsuya Ito2, Yoko Nakajima2, Sayaka Kato2, Shinji Saito2, Kazunori Kimura1 1 Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University 2 Department of Pediatrics, Graduate School of Medical Sciences, Nagoya City University

P-12 Mass spectrometric identification of epitiostanol metabolite: In vitro metabolism using human cryopreserved hepatocytes and human embryonic stem cell (hESC)-derived hepatocytes, and in vivo excretion study in human Mitsuhiko Sato1, Masato Okano1, Tomoharu Osada2, Ayako Uchiyama2, Shinji Kageyama1 1Anti-Doping Laboratory, Mitsubishi Chemical Medience Corporation 2Advanced Medical Science Research Department, Mitsubishi Chemical Medience Corporation

P-13 Analysis of metabolites in body fluid by gas chromatography-tandem mass spectrometry Shuichi Kawana1, Katsuhiro Nakagawa1, Haruhiko Miyagawa1, Yuki Hasegawa2 and Seiji Yamaguchi2 1 Analytical & Measuring Instruments Division, SHIMADZU CORPORATION 2 Department of Pediatrics, Shimane University School of Medicine

P-14 A novel serum metabolomics-based diagnostic approach for canine progressive myelomalacia Maho Sumita1, Hidetaka Nishida1,2, Reo Tamai1, Katsuhiro Tanaka1, Masayuki Komori1, Masanari Nakayama2 and Shigeo Takenaka1 1Dept. Vet. Sci. Osaka Pref. Univ, 2Nakayama Animal Hospital.

P-15 The measurement of serum uremic toxins in chronic kidney disease patients under conservative therapy with LC/MS/MS Kaori Kikuchi1, Yoshiharu Itoh1, Jun Usami2, Tsukasa Nakamura3, Toshimitsu Niwa4 1Kureha Corporation 2Aichi Medical University 3Shinmatsudo Central General Hospital 4Nagoya University Graduate School of Medicine

P-16 Development of ultra high sensitive method of sphingosine-1-phosphate by LC/MS/MS Tomohiro Takahashi, Daisuke Saigusa, Daisuke Jinno, Asuka Inoue, Michiyo Okutani, Junken Aoki, Naoto Suzuki, Yoshihisa Tomioka Graduate School of Pharmaceutical Sciences, Tohoku University

P-17 Ultra-high sensitive determination analysis of sphingosine-1-phosphate in mice brain by LC/MS/MS Daisuke Saigusa1, Tomohiro Takahashi1, Shiori Ootaku1, Asuka Inoue1, Michiyo Okutani1, Naoto Suzuki1, Nariyasu Mano2, Junken Aoki1, Yoshihisa Tomioka1 1 Graduate School of Pharmaceutical Sciences, Tohoku University 2 Department of Pharmaceutical Sciences, Tohoku University Hospital

P-18 Direct analysis of lipid molecular species in localized areas from tissue slices and segmented membrane by liquid extraction surface analysis (LESA) Ryo Taguchi1, Akinori Mizuno1, Yoshiki Mizuno1, Mana Yamaguchi1 and Kazutaka Ikeda2 1Chubu University, College of Life and Health Sciences 2Keio University, Institute for Advanced Biosciences

P-19 Analysis of prostanoids in rat brain microdialysis sample by liquid chromatography ion trap tandem mass spectrometry Masahiko Tachi, Fumio Kondo, Minoru Fukayama, Kazuhiro Yoshikawa, Shoshiro Okada1 Graduate School of Medicine, Aichi Medical University

P-20 Discovery of novel therapeutic agents for inflammatory diseases via metabolomics Shin Nishiumi1, Yoshihiro Izumi 1, Atsuki Matubara1, Takeshi Azuma1, Masaru Yoshida1 1Kobe University Graduate School of Medicine

P-21 A quantitation method of antiepileptic drugs (valproic acid and gabapentin), in patient plasma obtained using dried blood spot, by GC-EI-MS: Aiming at the clinical application to “micro TDM” Kayo Ikeda1, Kazuro Ikawa1, Yukari Imai1, Satoko Yokoshige1, Norifumi Morikawa1 1Department of Clinical Pharmacotherapy, Hiroshima University

P-22 MALDI-TOF mass spectrometric determination of gold and platinum in tissues Kayoko Minakata1, Masako Suzuki2, Hideki Nozawa1, Itaru Yamagishi1, Kunio Gonmori1, Koutaro Hasegawa1, Amin Wurita1, Kanako Watanabe1, Osamu Suzuki1 1Department of Legal Medicine, Hamamatsu University School of Medicine 2Research Equipment Center, Hamamatsu University School of Medicine

P-23 A rapid and simultaneous analysis of melatonin receptor agonists in human blood by ultra-performance liquid chromatography tandem mass spectrometry Tadashi Ogawa1, Masae Iwai1, Hideki Hattori1, Kenjiro Ito1, Tetsuya Arinobu1, Akira Ishii2, Osamu Suzuki3, Hiroshi Seno1 1 Aichi Medical University School of Medicine 2 Nagoya University Graduate School of Medicine 3 Hamamatsu University School of Medicine

P-24 Metabolism of methoxyamphetamines and fluoroamphetamines by human and mouse liver microsomes Kazuna Miyamoto1,2, Takuya Yamashita1, Mai Date1, Yukiko Nakazono3,2, Kenji Kuwayama3, Kenji Tsujikawa3, Yasuyoshi Miki4, Hiroyuki Inoue3, Fumiyo Kasuya1 1 Faculty of Pharmaceutical Sciences, Kobegakuin University, 2 Hitec, Inc., 3 National Research Institute of Police Science, 4 School of Pharmaceutical Sciences, Kinki University

P-25 A case of postmortem detected a designer drug , α -PVP and its metabolite Hiroshi Ochi1, Kazuo Igarashi1,2, Takeshi Hayashi1, Morio Iino1 1Osaka University Graduate School of Medicine Department of Legal Medicine, 2Association of Medicinal Analysis

P-26 Analysis of alpha-amanitin, beta-amanitin and Picrotoxin by High Resolution and Accurate Mass LC-MS/MS Miho Tada1, Hideki Hattori2, Tadashi Ogawa2, Akira Ishii3 1 K.K. AB SCIEX, 2Aichi Medical University, 3Nagoya University Graduate School of Medicine

P-27 Visualization of metabolite change in skeletal muscle by contraction using imaging mass spectrometry Naoko Goto-Inoue1, Yasuko Manabe1, Shouta Miyatake1, Ai Morishita1, Shinya Ogino1, Mitsutoshi Setou2, Nobuharu L. Fujii1 1Tokyo Metropolitan University 2Hamamatsu University School of Medicine

P-28 Analysis of phosphatidylcholines distribution in oral squamous cell carcinoma by imaging mass spectrometry Yoshiyuki Uchiyama1, Takahiro Hayasaka2, Noritaka Masaki2, Tetsuji Nagata1, Fuminori Katou1, Mitsutoshi Setou2 1Department of Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine. 2Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine.

P-29 Imaging mass spectrometric analyses of teeth section Hirokazu Hirano1, Takahiro Hayasaka2, Noritaka Masaki2, Yoshiko Watanabe1, Kazuma Masumoto1, Tetuji Nagata1, Fuminori Katou1 and Mitsutoshi Setou2 1 Department of Oral and Maxillofacial surgery, Hamamatsu Univ. Sch. of Med. 2 Department of Cell biology and anatomy, Hamamatsu Univ. Sch. of Med.

P-30 Visualization of lipid species on human retina using Mass Microscope

Takahiro Hayasaka1, Naoko Goto-Inoue1,2, Noritaka Masaki1, Norihiro Ogawa3, Takeshi Kanesaka3, Akira Hori3, Hiroyasu Akatsu3, Mitsutoshi Setou1 1Hamamatsu University School of Medicine 2Tokyo Metropolitan University 3Fukushimura Hospital

P-31 Development of Mass++ : A “Platform viewer” for mass spectrometry analysis Shinichi Utsunomiya1, Satoshi Tanaka1, Masaki Murase1, Tsuyoshi Tabata2, Ken Aoshima2, Yoshiya Oda2, Shigeki Kajihara1, Koichi Tanaka1 1 Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu corp. 2 Biomarkers and Personalized Medicine, Eisai Co. LTD.

14:00- 15:00 Oral Session 1 Chairperson: Kiyofumi Asai (Nagoya City University), Kazuo Takahashi (Fujita Health University School of Medicine)

O1-1 Synthesis of galactose-deficient IgA1 O-glycans by GalNAc-transferases expressed in IgA1-producing cells: implications for the pathogenesis of IgA nephropathy KazuoTakahashi1,3, Yoshiyuki Hiki2, Yukio Yuzawa1, Matthew B. Renfrow3, Jan Novak3 1Fujita Health University School of Medicine 2Fujita Health University School of Medical Science 3University of Alabama at Birmingham

O1-2 3-Deoxyglucosone trapping activity of pyridoxal 5’-phosphate as analyzed by electrospray ionization mass spectrometry Roumyana Mironova1, Ivaylo Ivanov2, Valentin Lozanov3, Silvia Russeva3, Svetlana Simova4, Ivan Ivanov1, Toshimitsu Niwa5 1Institute of Molecular Biology Roumen Tsanev, Sofia, Bulgaria 2University of Sofia St. Kliment Ohridski, Sofia,Bulgaria 3Medical University, Sofia, Bulgaria 4Institute of Organic Chemistry with Centre of Phytochemistry, Sofia, Bulgaria 5Nagoya University Graduate School of Medicine, Nagoya, Japan

O1-3 Detection of long-acting erythropoiesis stimulating agent darbepoetin alfa in human urine by ultra-performance liquid chromatography tandem mass spectrometry Masato Okano, Mitsuhiko Sato, Shinji Kageyama Anti-Doping Laboratory, Mitsubishi Chemical Medience Corporation

O1-4 Study of relation between the effect of bezafibrate and results of in vitro probe acylcarnitine assay in neonatal onset type of glutaric acidemia type II Kenji Yamada1, Hironori Kobayashi1, Jamiyan Purevsuren1, Tomoo Takahashi1, Yuki Hasegawa1, Seiji Yamaguchi1 1Shimane University faculty of medicine

15:10- 17:10 Symposium 2 Organizer: Tetsuya Itou (Nagoya city University) Yosuke Shigematsu (Fukui University) S2-1 Gas chromatography/mass spectrometric measurement of organic acids in dried blood spots for newborn screening by tandem mass spectrometry Yosuke Shigematsu1, Ikue Hata2 1Department of Health Science, University of Fukui 2Department of Pediatrics, University of Fukui

S2-2 Selective screening for high risk infants with metabolic disorders in Sapporo city Junji Hanai1, Miwa Yoshinaga1, Yu Ota1, Hiroo Takahashi1, Taiko Sasaki1, Shosuke Nomachi2, Masayoshi Nagao3, Mitsuru Kubota4 1Sapporo City Institute of Public Health 2Environmental Bureau, Sapporo City 3Hokkaido Medical Center 4Saitama Childeren’s Medical Center

S2-3 Neonatal screening for inherited metabolic disorders by GC/MS using urine samples Takahiro Inokuchi1, Kumiko Aoki1, Kyoko Tashiro1, Misa Inaba1, Kaori Inoue1, Chihiro Yanagiuchi1, Yuri Suzutani1, Yoriko Watanabe1,2, Toyojiro Matsuishi1,2 Research Institute of Medical Mass Spectrometry, Kurume University School of Medicine 2Department of Pediatrics and Child Health, Kurume University School of Medicine

S2-4 Urinary organic acids analysis using GC/MS in Shimane University Yuki OMURA-HASEGAWA, Jamiyan PUREVSUREN, Kenji YAMADA, Tomoo TAKAHASHI, Hironori KOBAYASHI, Seiji YAMAGUCHI Department of Pediatrics, Shimane University, School of Medicine

S2-5 Metabolic profile analysis and pathological analysis by GC/MS Chunhua Zhang Department of research & development of MILS International

17:30- 19:30 Banquet

September 26(Friday)

9:10-10:40 Symposium 3 Organizer: Hiroshi SENO (Aichi Medical University) Fumio Moriya (Kawasaki University of Medical Welfare)

S3-1 Some difficulties peculiar to postmortem analysis of drugs and chemicals Kei Yoshitome1、Satoru Miyaishi1、Fumio Moriya1,2 1 Department of Legal Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 2 Department of Nursing, Kawasaki University of Medical Welfare

S3-2 Development of standardized screening system in Japan for forensic samples Keiko Kudo, Noriaki Ikeda Graduate School of Medical Sciences, Kyushu University

S3-3 LC/MS/MS and QTOF confirmation method of benzodiazepines in autopsy sample Makiko Hayashida1, Hiroko Abe2, Masahiko Takino3, Youkichi Ohno1 1 Department of Legal Medicine, Nippon Medical School, ，2 MST, Tokyo，3 Agilent Technologies, Tokyo

10:50-11:50 Invited lecture

Matsumoto and Tokyo Subway Sarin Attack from the Viewpoint of Toxicology Tamie Nasu1 1Chubu University

12:00-12:40 Luncheon Seminar

The Improvement of Peak Separation Capacity in Comprehensive Measurement and Data Processing Methodology Using LC/MS -Chromatography and Ion Mobility Futoshi Sato Nihon Waters K.K. Marketing Development Technology Center

12:50-13:20 Isamu Matsumoto” Prize lecture

Study on clinical application of mass spectrometry: detection and evaluation of metabolic disorders of organic and fatty acids using GC/MS and MS/MS Seiji Yamaguchi Department of Pediatrics, Shimane University School of Medicine

13:20-14:40 Oral Session 2 Chairperson: Fumio Kondo (Aichi Medical University), Makiko Hayashida (Nippon Medical School)

O2-1 Establishment of the colorectal cancer screening system via serum metabolome analysis Masaru Yoshida1, Shin Nishiumi1, Yoshihiro Izumi1, Atsuki Matsubara1, Takeshi Azuma1 1Kobe University Graduate School of Medicine

O2-2 An assay of methylmalonyl-CoA-mutase by Ultra-performance liquid chromatography tandem mass spectrometry Tetsuya Nasu1, Yasuhiro Maeda1, Yuji Hotta1, Tetsuya Ito２, Yoko Nakajima2, Sayaka Kato2, Sinji Saito2, Kazunori Kimura1 1Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University 2Department of Pediatrics, Graduate School of Medical Sciences, Nagoya City University

O2-3 Proteomic analysis of ligamentum flavum with hypertrophy from lumbar spinal canal stenosis patients Yuichiro Goda1, Takako Taniguchi2, Nori Sato1、Natsuo Yasui1, Hisaaki Taniguchi2 1Department of Orthopedics, Tokushima University 2Division of Disease Proteomics, Institute for Enzyme Research, Tokushima University

O2-4 A Systematic Approach to Avoid the Matrix Effect during LC-ESI-MS/MS Analysis by Using Chemical Property Parameters of Compounds Masato Iwaya1, Ken-ichi Harada1, 2 1Meijo University, Faculty of Pharmacy 2Meijo University, Graduate School of Environmental and Human Sciences

O2-5 Metabolomics of urine and blood plasma in rat models of drug addiction on the basis of conditioned place preference Kei Zaitsu1, Izuru Miyawaki2, Tomoaki Tochitani2, Kiyoko Bando2, Yasushi Horie2, Noriaki Shima1, Munehiro Katagi1, Michiaki Tatsuno1, Takeshi Bamba3, Hitoshi Tsuchihashi4, Eiichiro Fukusaki3 1Forensic Science Laboratory, Osaka Prefectural Police H.Q. 2Dainippon Sumitomo Pharma, Toxicology, Safety Research Laboratories 3Department of Biotechnology, Graduate School of Engineering, Osaka University 4Department of Legal Medicine, Osaka Medical College

14:50-15:50 Technical workshop1 Chairperson: Ikai Yoshitomo (Aichi Prefectural Institute of Public Health),

WS-1 Fast and Selective Screening of Drugs in Urine using LDTD-Qq-TOF mass spectrometry Tetsuo Kokaji1, Miho Tada1, Toshiyuki Yamazaki1 1K.K AB SCIEX

WS-2 About the possibility of the DBS and other flat surface ample ( Microtome Tissue Sample, TLC Plate, Membrane, others ) analysis by LESA ( Liquid Extraction Surface Analysis ). Yoshiharu Naito1 1Advion Japan k.k.

WS-3 Comprehensive screening approach by LC/Q-TOFMS using exact mass database, MSMS library and Molecular structure correlation (MSC) for forensic toxicological samples Masahikio Takino1, Hirokazu Sawada1, Makiko Hayashida2 1Agilent Technologies Japan, Ltd. 2 Department of Legal Medicine, Nippon Medical School

WS-4 LC-MS/MS analysis of drug and metabolites from Dry Blood Spot Yasuhiko Bando1, Souki Kanda1, Takatomo Kawamukai1, Hiroshi Hike2, Amane Sakurai1 1AMR, Inc. 2Toray Research Center, Inc.

15:50-16:35 Technical workshop2

WS-5 Marker discovery research using multivariate analysis software "SIMCA" Shigetoshi Yoshikawa INFOCOM CORPORATION

WS-6 Stable Isotopes in Bio Mass Spectrometry Yoshinori Fujimine Otsuka Pharmaceutical Co., LTD Diagnostic Division.

WS-7 The Shimadzu LC/MS product portfolio Ichiro Hirano1, Natsuyo Asano1, Shinjiro Fujita1, Daisuke Okumura2, Kazuo Mukaibatake1 1Mass Spectrometry Business Unit, Shimadzu Corporation

16:35 Closing Remarks

The 37th Annual Meeting of the Japanese Society for Biomedical Mass Spectrometry President of the 37th Annual Meeting: Akira Ishii, MD. , Ph.D. Professor, Department of Legal Medicine and Bioethics , Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, Aichi, 466-8550, JAPAN Tel: +81-52-744-2117 Fax: +81-52-744-2121 E-mail: [email protected]

Japanese Society for Biomedical Mass Spectrometry President: Niwa Toshimitsu Professor, Department of Advanced Medicine for Uremia, 65 Tsuruma-cho, Showa-ku, Nagoya, Aichi, 466-8550, JAPAN Tel: +81-52-744-1980 Fax: +81-52-744-1954 E-mail: [email protected] URL: http://www.jsbms.jp/english/