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Aichi Industry & Labor Center The 37th Annual Meeting of the Japanese Society for Biomedical Mass Spectrometry Program October 25th(Thu) – 26th(Fri), 2012 Aichi Industry & Labor Center (WINC AICHI), 5F Small Hall and 6F Exhibition Space 4-38 Meieki-4, Nakamura-ku, Nagoya-city, Aichi, Japan Akira Ishii, MD. , Ph.D. President of the 37th Annual Meeting of the Japanese Society for Biomedical Mass Spectrometry Department of Legal Medicine and Bioethics Nagoya University Graduate School of Medicine 65 Tsurumai-cho, Showa-ku, Nagoya-city, Aichi, Japan Tel: +81-52-744-2117 Fax: +81-52-744-2121 E-mail: [email protected] Time Schedule October 25 (Thursday) 9:25- 9:30 Opening Remarks 9:30- 11:30 Symposium 1 11:40- 12:20 Luncheon Seminar / Board Meeting 12:20- 12:50 JSBMS General Meeting 13:00- 14:00 Poster Presentation 14:00- 15:00 Oral Session 1 15:10- 17:10 Symposium 2 17:30- 19:30 Banquet October 26 (Friday) 9:10-10:40 Symposium 3 10:50-11:50 Invited lecture 12:00-12:40 Luncheon Seminar 12:50-13:20 Isamu Matsumoto” Prize lecture 13:20-14:40 Oral Session 2 14:50-15:50 Technical workshop1 15:50-16:35 Technical workshop2 16:35 Closing Remarks Program September 25(Thursday) 9:25- 9:30 Opening Remarks (Akira Ishii) 9:30- 11:30 Symposium 1 Organizer: Fumio Nomura (Chiba University), Toyofumi Nakanishi (Osaka Medical College) S1-1 The ”ABC” of proteomics focused on post-translational modifications. Naoshi Dohmae1 1RIKEN Advanced Science Institute S1-2 Identifications of amyloidogenic proteins in FFPE tissue sections of amyloidoses and traceabilities of drugs/medicine histories in sliced hair sections by MALDI-imaging Toyofumi Nakanishi Department of Clinical and Laboratory Medicine, Osaka Medical College S1-3 Quantitative proteomics of serum for diagnostic applications. Mamoru Satoh1,2,4, Yusuke Kawashima3, Kazuyuki Sogawa1,2, Tatsuya Saito3, Sayaka Kado4, Fumio Nomura1,2 1Clinical Proteomics Research Center, Chiba University Hospital 2Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University 3Center for Disease Proteomics, School of Science, Kitasato University 4Chemical Analysis Center, Chiba University S1-4 In vitro diagnostics - development to medical reimbursement Masahiro Hashiguchi Medical and Biologocal Laboratories Co.,LTD. Sales and Marketing Division 11:40- 12:20 Luncheon Seminar / Board Meeting Application of a triple quadrupole mass spectrometer on the forensic medicine Toshikazu Minohata (Shimadzu Corporation) 12:20- 12:50 JSBMS General Meeting 13:00- 14:00 Poster Presentation P-1 Apolipoprotein E Serotyping Motoi Nishimura1,2,3, Satomi Nishimura1, Mamoru Satoh1,3, Syoko Kakinuma1, Kenichi Sato2, Setsu Sawai1,2, Sayaka Kado4, Yoshio Kodera3,5, Fumio Nomura1,2,3 1Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University 2Division of Laboratory Medicine and Clinical Genetics, Chiba University Hospital 3Clinical Proteomics Research Center, Chiba University Hospital 4Chemical Analysis Center, Chiba University 5Laboratory of Biomolecular Dynamics, Department of Physics, School of Science, Kitasato University P-2 Search for novel lung cancer biomarkers by proteomic analysis of exosomal membrane Takuya Yamashita1,2,3, Kazuya Nagano2, So-ichiro Kanasaki2,3, Yuka Maeda2,3, Hiromi Nabeshi2,3, Tomoaki Yoshikawa2,3,Yasuo Yoshioka2,3,4, Masaki Inoue2, Yasuhiro Abe2, Haruhiko Kamada2,4, Fumiyo Kasuya1, Yasuo Tsutsumi2,3,4,Shin-ichi Tsunoda2,3,4 1 Faculty of Pharmaceutical Sciences, Kobegakuin University. 2 National Institute of Biomedical Innovation. 3 Graduate School of Pharmaceutical Science, Osaka University. 4 The Center for Advanced Medical Engineering and Informatics, Osaka University. P-3 Calculation of O-glycosylation site occupancy based on the peak intensity of peptide/glycopeptide ions in MALDI mass spectrum Yoshinao Wada、Machiko Kadoya Osaka Medical Center and Research Institute for Maternal and Child Health P-4 Optimization of rapid identification of microorganism by MALDI-TOFMS and its application for diagnosis of severe infectious disease Toyofumi Nakanishi1, Tomohiro Higashiyama2, Yumiko Matsuyama3, Takayuki Takubo1 1Department of Clinical and Laboratory Medicine, Osaka Medical College 2Central Clinical Laboratory, Osaka Medical College Hospital 3Technical Support Center, Bruker Daltonics K. K. P-5 Discrimination between methicillin-sensitive and methicillin-resistant Staphylococcus aureus by MALDI-TOF mass spectrometry Kazuyuki Sogawa1, Masaharu Watanabe2, Fumie Iida1,Syunsuke Segawa2, Akiko Miyabe2, Syota Murata2, Tomoko Saito2, and Fumio Nomura1,2,3 1Clinical Proteomics Research Center, Chiba University Hospital 2Department of Clinical Laboratory, Chiba University Hospital 3Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University P-6 Exploring of blood markers in early stages of chronic renal failure in rat Toshihiro Kobayashi1, Yuriko Matsumura1, Atsuo Iwasawa1, Toshihiko Ozawa1, Toshiaki Kamachi1, Tatsuya Fujisawa2, Kouichi Fujiwara2, Masahiro Kohno1, Noriaki Tanaka2 1Tokyo Institute of Technology 2Tanaka-Kitanoda Hospital P-7 Characterization of phase II metabolism of tetrahydrocorticosteroids in human liver by LC/MS Kuniko Mitamura1, Mami Kamibayashi1, Kanta Sato1, Sachi Fujioka1, Masataka Nakajima1, Rika Satoh (née Okihara)2, Takashi Iida2, Shigeo Ikegawa1 1 Faculty of Pharmaceutical Sciences, Kinki University 2 College of Humanities & Sciences, Nihon University P-8 Analysis of Steroid Hormones in Human Saliva and Serum using Column-switching Ultra-fast LC/MS/MS Yukiko Hirabayashi 1, Takashi Shinagawa 2, Joji Suzuki 2, Toshio Kaji 2 1 Central Research Laboratory, Hitachi, Ltd. 2 Hitachi Yokohama Hospital, Hitachi, Ltd. P-9 TBARS does not reflect the level of phosphatidylcholine hydroperoxides in oxidized lipoproteins Shu-Ping Hui1, Toshihiro Sakurai1, Shigeki Jin1, Hirotoshi Fuda1, Seiji Takeda1, Takao Kurosawa2, Hitoshi Chiba1 1Faculty of Health Sciences, Hokkaido University, Japan 2Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan P-10 Simultaneous analysis of 16 plasma isoflavone metabolites in 5 age-matched young women by liquid chromatography tandem mass spectrometry Kaori Hosoda1, Akitomo Yokokawa2, Hiromi Shibasaki2, Takashi Furuta2, Kazuo Ishii1 1Kyorin University, School of Health Sciences 2Tokyo University of Pharmacy and Life Sciences, School of Pharmacy P-11 Determination of pyrimidine metabolites for inborn error of pirimidine metabolism by UPLC-MS/MS Yasuhiro Maeda1, Ayumi Kato1, Tetsuya Ito2, Yoko Nakajima2, Sayaka Kato2, Shinji Saito2, Kazunori Kimura1 1 Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University 2 Department of Pediatrics, Graduate School of Medical Sciences, Nagoya City University P-12 Mass spectrometric identification of epitiostanol metabolite: In vitro metabolism using human cryopreserved hepatocytes and human embryonic stem cell (hESC)-derived hepatocytes, and in vivo excretion study in human Mitsuhiko Sato1, Masato Okano1, Tomoharu Osada2, Ayako Uchiyama2, Shinji Kageyama1 1Anti-Doping Laboratory, Mitsubishi Chemical Medience Corporation 2Advanced Medical Science Research Department, Mitsubishi Chemical Medience Corporation P-13 Analysis of metabolites in body fluid by gas chromatography-tandem mass spectrometry Shuichi Kawana1, Katsuhiro Nakagawa1, Haruhiko Miyagawa1, Yuki Hasegawa2 and Seiji Yamaguchi2 1 Analytical & Measuring Instruments Division, SHIMADZU CORPORATION 2 Department of Pediatrics, Shimane University School of Medicine P-14 A novel serum metabolomics-based diagnostic approach for canine progressive myelomalacia Maho Sumita1, Hidetaka Nishida1,2, Reo Tamai1, Katsuhiro Tanaka1, Masayuki Komori1, Masanari Nakayama2 and Shigeo Takenaka1 1Dept. Vet. Sci. Osaka Pref. Univ, 2Nakayama Animal Hospital. P-15 The measurement of serum uremic toxins in chronic kidney disease patients under conservative therapy with LC/MS/MS Kaori Kikuchi1, Yoshiharu Itoh1, Jun Usami2, Tsukasa Nakamura3, Toshimitsu Niwa4 1Kureha Corporation 2Aichi Medical University 3Shinmatsudo Central General Hospital 4Nagoya University Graduate School of Medicine P-16 Development of ultra high sensitive method of sphingosine-1-phosphate by LC/MS/MS Tomohiro Takahashi, Daisuke Saigusa, Daisuke Jinno, Asuka Inoue, Michiyo Okutani, Junken Aoki, Naoto Suzuki, Yoshihisa Tomioka Graduate School of Pharmaceutical Sciences, Tohoku University P-17 Ultra-high sensitive determination analysis of sphingosine-1-phosphate in mice brain by LC/MS/MS Daisuke Saigusa1, Tomohiro Takahashi1, Shiori Ootaku1, Asuka Inoue1, Michiyo Okutani1, Naoto Suzuki1, Nariyasu Mano2, Junken Aoki1, Yoshihisa Tomioka1 1 Graduate School of Pharmaceutical Sciences, Tohoku University 2 Department of Pharmaceutical Sciences, Tohoku University Hospital P-18 Direct analysis of lipid molecular species in localized areas from tissue slices and segmented membrane by liquid extraction surface analysis (LESA) Ryo Taguchi1, Akinori Mizuno1, Yoshiki Mizuno1, Mana Yamaguchi1 and Kazutaka Ikeda2 1Chubu University, College of Life and Health Sciences 2Keio University, Institute for Advanced Biosciences P-19 Analysis of prostanoids in rat brain microdialysis sample by liquid chromatography ion trap tandem mass spectrometry Masahiko Tachi, Fumio Kondo, Minoru Fukayama, Kazuhiro Yoshikawa, Shoshiro Okada1 Graduate School of Medicine, Aichi Medical University P-20 Discovery of novel therapeutic agents for inflammatory diseases via metabolomics Shin Nishiumi1, Yoshihiro Izumi 1, Atsuki Matubara1, Takeshi Azuma1, Masaru Yoshida1 1Kobe
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