Supplemental Table 1. profile of MMTV-Pax8PPARγ mice. Changes in in the mammary gland from transgenic mice are expressed as the -fold change vs. wild-type FVB mice.

Pathway Accession No. -Fold Change Gene PI3K NM_011062 13.2 Pdpk1 3-phosphoinositide dependent kinase-1 (PDK1) NM_011083 6.0 Pik3c2a phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide NM_001024955 3.8 Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) AL928653 3.4 Pip5k2a phosphatidylinositol-4-phosphate 5-kinase, type II, alpha NM_145452 3.5 Rasa1 RAS p21 protein activator 1 Receptors NM_009063 7.1 Rgs5 regulator of G-protein signaling 5 NM_008591 4.7 Met met proto-oncogene NM_010284 4.4 Ghr growth hormone receptor NM_009370 3.3 Tgfbr1 transforming growth factor, beta receptor I NM_011019 3.4 Osmr oncostatin M receptor NM_010560 4.9 IL6ST IL-6 signal transducer NM_009704 -8.0 Areg amphiregulin Kinases NM_011951 3.8 Mapk14 mitogen activated protein kinase 14 NM_009274 3.8 Srpk2 serine/arginine-rich protein specific kinase 2 NM_010237 4.3 Frk fyn-related kinase BC043660 3.6 Prkcn protein kinase C, nu NM_011518 3.1 Syk spleen tyrosine kinase Jak/Stat NM_146145 10.0 Jak1 Janus kinase 1 NM_213659 3.9 Stat3 signal transducer and activator of transcription 3 NM_011169 4.0 Prlr prolactin receptor Wnt NM_009524 3.7 Wnt5a wingless-related MMTV integration site 5A NM_008055 3.2 Fzd4 frizzled homolog 4 (Drosophila) NM_007614 5.1 Ctnnb1 catenin (cadherin associated protein), beta 1, 88kDa Angiogenesis NM_026218 4.4 Fgfr1op2 FGFR1 oncogene partner 2 NM_009640 5.2 Angpt1 angiopoietin 1 NM_025367 3.2 Sphk1 sphingosine kinase 1 Nuclear Receptors NM_008904 9.7 Ppargc1a peroxisome proliferative activated receptor, gamma, 1 alpha (PGC-1α) NM_011584 5.7 Nr1d2 nuclear receptor subfamily 1, group D, member 2 NM_008173 5.5 Nr3c1 nuclear receptor subfamily 3, group C, member 1 NM_019744 4.4 Ncoa4 nuclear receptor coactivator 4 Transport NM_013454 8.8 Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 NM_009592 4.2 Abcb7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 NM_008576 3.3 Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 NM_011994 3.2 Abcd2 ATP-binding cassette, sub-family D (ALD), member 2 Mitosis NM_173762 5.5 Cenpe centromere protein E NM_008448 3.9 Kif5b kinesin family member 5B NM_008441 3.8 Kif1b kinesin family member 1B NM_010615 3.5 Kif11 kinesin family member 11 NM_021505 3.4 Anapc5 anaphase-promoting complex subunit 5 NM_009409 5.0 Top2b topoisomerase (DNA) II beta NM_134097 4.5 Topors topoisomerase I binding, arginine/serine-rich NM_009409 3.6 Top2b topoisomerase (DNA) II beta Adhesion NM_023463 6.9 Ly6g6c lymphocyte antigen 6 complex, G6C NM_023842 5.9 Dsp desmoplakin NM_001005868 4.3 Erbb2ip Erbb2 interacting protein NM_009502 4.3 Vcl vinculin NM_009851 3.9 Cd44 CD44 antigen AL929390 3.8 Edg2 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 NM_019549 3.7 Plek pleckstrin NM_016674 3.4 Cldn1 claudin 1 NM_011519 3.5 Sdc1 syndecan 1 NM_007483 -3.2 Rhob ras homolog gene family, member B Cell Cycle NM_009829 6.6 Ccnd2 cyclin D2 NM_007631 3.9 Ccnd1 cyclin D1 NM_025950 3.8 Cdc37l1 cell division cycle 37 homolog (S. cerevisiae)-like 1 NM_013685 3.3 Tcf4 transcription factor 4 NM_010234 3.5 Fos FBJ murine osteosarcoma viral oncogene homolog NM_013672 3.3 Sp1 trans-acting transcription factor 1 NM_133966 3.6 Pcaf p300/CBP-associated factor NM_011416 3.4 Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a NM_007759 4.2 Crabp2 cellular retinoic acid binding protein II BC064079 3.2 Mll5 myeloid/lymphoid or mixed-lineage leukemia 5 NM_013842 3.4 XBP1 X-box binding protein1 NM_009875 -3.3 Cdkn1b cyclin-dependent kinase inhibitor 1B (P27) NM_030714 -3.2 Dtx3 deltex 3 homolog (Drosophila) Apoptosis BX530028 6.0 Birc4 baculoviral IAP repeat-containing 4 NM_011613 -7.2 Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 Invasion NM_011594 3.4 Timp2 tissue inhibitor of metalloproteinase 2 NM_008608 3.3 Mmp14 matrix metallopeptidase 14 (membrane-inserted) NM_080639 -3.5 Timp4 tissue inhibitor of metalloproteinase 4