Blood Volume in Newborn Piglets: Effects of Time of Natural Cord Rupture, Intra-Uterine Growth Retardation, Asphyxia, and Prostaglandin-Induced Prematurity
Pediatr. Res. 15: 53-57 (1981) asphyxia natural cord rupture blood volume prostaglandin F 2 intra-uterine growth retardation Blood Volume in Newborn Piglets: Effects of Time of Natural Cord Rupture, Intra-Uterine Growth Retardation, Asphyxia, and Prostaglandin-Induced Prematurity 137 OTWIN LINDERKAMP, , KLAUS BETKE, MONIKA GUNTNER, GIOK H. JAP, KLAUS P. RIEGEL, AND KURT WALSER Department of Pediatrics and Department of Veterinary Gynecology, University of Munich, Munich, Federal Republic of Germany Summary (27, 29, 32). Placental transfusion is accelerated by keeping the infant below the placenta (19, 27), by uterine contractions (32), Blood volume (BV), red cell mass (RCM; Cr-51) and plasma 125 and by respiration of the newborn (19). Placental transfusion is volume ( 1-labeled albumin) were measured in lOS piglets from prevented by holding the infant above the placenta (19, 27), by 28 Utters shortly after birth. Spontaneous cord rupture in healthy maternal hypotension ( 17), by tight nuchal cord ( 13), and by acute piglets occurred during delivery (n • 25) or within 190 sec of birth intrapartum asphyxia (5, 12, 13). Intra-uterine asphyxia results in (n • 82). Spontaneous and induced delay of cord rupture resulted prenatal transfusion to the fetus (12, 13, 33). In a time-dependent Increase in BV and RCM. BV (x ± S.D.) at It is to be assumed that blood volume in newborn mammals is birth was 72.5 ± 10.5 ml/kg (RCM, 23.6 ± 4.6 ml/kg) In the 25 similarly influenced by placental transfusion as in the human piglets with prenatal cord rupture and 110.5 ± 12.9 ml/kg (RCM, neonate.
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