A Publication of The Cancer Institute of New Jersey Winter 2 012

Examining the ‘Circle of Health’

ompared to Cauca- current research efforts as part the evaluation of these poten - sian women, African- of a new consortium of four tial risk factors, the research- CAmerican women are studies in African-American ers hope to deter mine how more likely to be diagnosed women. they relate to the early devel - with breast cancer at a younger The Women’s Circle of opment of breast cancer in the age and at a later stage, and Health Study, the Carolina African-

have more aggressive features Breast Cancer Study, the Black K American i m S associated with poor progno - o Women’s Health Study, and k population. o l o

f Dr. Elisa Bandera sis. However, the reasons for the Multiethnic Cohort Study f “Most these differences remain un- will examine 5,500 women on this subject. In all, the studies known. To address these issues, with breast cancer and 5,500 National Cancer Institute of The Cancer Institute of New women without cancer, repre - awarded $19.3 million to breast Jersey (CINJ) is expanding its senting the largest study to date support the collaborative cancer effort, which is being led by have been con - Christine Ambrosone, PhD, ducted in Caucasian women. Inside the CINJ Foundation Roswell Park Cancer Institute; Therefore, there is great need Julie Palmer, ScD, Boston Uni- for studies like this, focusing Celebrating a ‘Spectrum of Promise’ versity; and Robert Millikan, on African-American women PhD, University of North and with large enough num - Carolina at Chapel Hill. bers to be able to study the The Women’s Circle of rare breast cancer subtypes, Health Study, based at CINJ which tend to be more com - and led by epidemiologist Elisa mon in African- American Bandera, MD, PhD , will receive women,” noted Dr. Bandera, $1.6 million in funding to con- who is also an associate tinue recruiting women from professor of epidemiology at

K an expanded target area across UMDNJ-Robert Wood y o M

o New Jersey . Johnson Medical School and r i s h i m

a Investigators are gathering UMDNJ-School of Public P h o t

o demographic and medical in- Health. g r a p

h formation, as well as repro - y To learn more, visit: ductive, lifestyle and diet his - t was a night of celebration, as the CINJ Foundation recently honored pillars http://cinjweb.umdnj.edu/ tories. Saliva and tumor sam - in the cancer community at its annual Award of Hope Gala. Turn to page 12, CircleofHealth, or call Iwhere you’ll see more of this special evening. ples are also collected for 732-235-9874 molecular analyses. Through Go to Contents Page 1 Director’s Corner

Winter 2012 In this Issue: “

iscovery consists of seeing what everyone J o

1 h Examining the ‘Circle of Health’ ...... n

D E else has seen and thinking what no one else has m e r s o Research thought.” That sentiment by Nobel Prize-winning n physicist Albert Szent-Györgyi captures the essence Menthol Cigarettes May Make it Tougher of what physician-scientists at The Cancer Institute of to Quit Smoking for Certain Populations ...... 3... New Jersey strive for each and every day – to engage in new ways of looking Energy Boost ...... 3... at the biology of cancer. Additionally, and most importantly; however, physician- Faculty Feature: Edmund C. Lattime, PhD ...... 4... scientists at CINJ work passionately at the process of discovery for a purpose: to cure and prevent cancer. Treatme nt In fact, we are well on this road to the cure. Not too long ago, deciphering the Clinical Trials Corner: sequence of a single human gene was difficult; today, we know the sequence of the Direct Injection Vaccine Treatment entire human genome. A few years ago, we knew little of what made a cancer cell for Pancreas Cancer Associated with Stable Disease ...... 5... different from a normal one; today, we know almost every one of those differences. Such scientific discoveries could be described as a ‘spectrum of promise,’ with each Building a Better Predictor ...... 6... new finding continuing to advance our collective knowledge in the oncology field. Robotic Surgery and Gynecologic Cancers ...... 6... At CINJ, our investigators remain on the cutting-edge of cancer research, unlocking new clues that will serve as a strong foundation for future scientific advancements. Prevention As you’ll read in our cover story, the Women’s Circle of Health study, led by CINJ The Time is Right to Save your Life ...... 7... epidemiologist Dr. Elisa Bandera , aims to further examine the mysteries of breast ‘Jersey Girl’ Study at CINJ Looks at cancer by studying the disease in African-American women. Information collected Understudied Hormone Disruptors ...... 8... from this study will be merged with findings from three other large studies from Another Successful Prostate Cancer Screening Event ...... 8... across the nation. Upon completion, researchers will have a data set of more than ten-thousand from which to draw conclusions relating to this segment of the popu - Education lation, which is more likely to be diagnosed with breast cancer at a younger age and at a later stage than compared to Caucasian women. Outreach Director at CINJ Tapped for National Program ...... 8... And we’re breaking new ground in the area of cancer vaccine therapy. Led by CINJ Deputy Director Dr. Edmund Lattime and CINJ’s co-director of the Sharing a Survivor’s Moment ...... 8... Gastrointestinal/Hepatobiliary Oncology Program, Dr. Elizabeth Poplin , investiga - Save the Date ...... 9... tors are in the midst of a unique clinical trial that aims to harness the body’s own On Tour ...... 9... defense mechanisms in fighting pancreatic cancer. Early results are showing an association with stable disease, following a direct vaccine injection into the tumor Inside CINJ itself (see page 5) . Kudos! ...... 9... None of these discoveries happen without collaboration. CINJ investigators are CINJ Network Spotlight: working closely with CINJ member Dr. Anant Madabhushi of Rutgers, The State New Treatment and Support Services University of New Jersey, in helping to bring new imaging technologies to the at Steeplechase Cancer Center ...... 10.... patient bedside. As you’ll read on page 6, Dr. Madabhushi recently was awarded a New Leadership for CINJ Hamilton ...... 10.... grant to develop a better tool to predict breast cancer aggressiveness.

CINJ Physicians Voted “Tops” ...... 11.... It is advancements such as these that we recently celebrated with the CINJ Foundation during its annual Award of Hope Gala, which boasted the theme — ever Inside the CINJ Foundation so appropriately — ‘Spectrum of Promise’ (see page 12) . It is through the support of our collaborators and all of you that we are able to fulfill our mission. We hope you Award of Hope Gala Brings Promise ...... 12.... will continue with us on this journey. Training Future Breast Cancer Surgeons ...... 13.... Sincerely, New Trustees Join Board ...... 14....

On the Road to a Cure ...... 14.... Robert S. DiPaola, MD Students and Communities for a Cause ...... 15.... Director, CINJ; Associate Dean for Oncology Programs and Professor A Giving Spirit at Exit 109 ...... 16.... of Medicine, UMDNJ-Robert Wood Johnson Medical School

2 R • Research e s e a r

Energy Boost c Menthol Cigarettes May h Make it Tougher to Quit Smoking he metabolism of cancer cells has attracted great attention in the last few for Certain Populations T years. Energy metabolism is an essen - tial function sustaining the increase in cancer cells by division, the movement of cancer cells ould a mint-flavored addi - investiga tors focused on white, black from one place to another, and survival of cancer tive to cigarettes have a neg - and Hispanic “ever-smokers,” who were cells. Both normal and cancer cells utilize two Cative impact on smoking defined as current smokers and former major pathways to satisfy cessation efforts? Recent research smokers who quit in the past five years. their energetic demands. from investigators at The Cancer Overall, menthol smoking was more One is glycolysis, the Institute of New Jersey and common among females and young conversion of the simple L i n adults, ages 18 to 24. Menthol z UMDNJ-School of Public Health P sugar glucose into lactate. h o t o

smoking varied considerably by race/ g finds that menthol cigarettes are r The other is mitochondrial a p h associated with decreased quitting in ethnicity; among blacks, 71.8 percent y respiration. Both path - the United States and that this effect smoked menthols, which is significantly Alexei Vazquez, PhD ways can generate energy is more pronounced for blacks and greater than whites (21 percent) and from glucose, however mitochondrial respiration Puerto Ricans. The findings Hispanics (28.1 percent). However, is sixteen times more efficient in terms of how appeared in the American Journal of among Hispanics there were wide much energy is produced per molecule of glucose . Preventive Medicine (doi:10.1016/ variations. Men thol smoking was more About a century ago, it was observed that j.amepre.2011.06.039) in October. common among those of Puerto Rican cancer cells have an increased use of glycolysis Previous studies regarding the descent (62 percent) than among those relative to normal cells. However, the reason of impact of smoking menthol cigarettes of Mexican (19.9 percent) and other why cancer cells rely more on this inefficient and smoking cessation efforts have Hispanic origins (26.5 percent). pathway has remained a puzzle until today. produced mixed results. For instance, The study further found that CINJ systems biologist Alexei Vazquez, some research did not take into menthol cigarette smoking was PhD , and his collaborators have observed that account the overall population of associated with lower levels of smoking glycolysis is a simpler pathway, with fewer steps smokers, while other studies lacked cessation compared to non-menthol and broken down by enzymes of smaller size focus on periods of successful smoking smokers. than those required for mitochondrial respiration . cessation and instead targeted attempts CINJ Member Cristine Delnevo, In a loose space, those size differences would to quit. This current study, Smoking PhD, MPH , director of the Center for not be an issue. However, the intracellular make - Cessation Prevalence among Menthol Tobacco Surveillance and Evaluation up is a crowded environment and the cell is very and Non-Menthol Smokers in the Research Program and interim chair, sensitive to any attempt of overcrowding. To United States , looks at whether those Department of Health Education and handle this physical constraint, cancer cells who smoke menthol cigarettes are less Behavioral Science at UMDNJ-School switch from mitochondrial respiration to likely to quit than smokers of non- of Public Health, is the lead author of glycolysis. menthol cigarettes and whether these the study. The work by Dr. Vazquez’s group has also findings differ by race/ethnicity as well shown that the switch to glycolysis is aided by as among various subgroups of smok - The research was supported by a concurrent increase of the protein building ers, such as those trying to quit. the FDA Center for Tobacco Products; block known as glutamine, which is another Utilizing data from the 2003 and however, the work and conclusions hallmark of cancer cell metabolism. More sur - 2006-2007 National Cancer Institute of this study are solely prisingly, it has predicted that there is a third Tobacco Use Supplement to the those of the authors pathway that lies between glycolysis and Current Population Survey, and not the FDA. mitochondrial respiration in terms of energy yield and crowding. Vazquez, who is also an assistant professor of radiation oncology at UMDNJ-Robert Wood Johnson Medical School, and his group are investigating the inhibition of these pathways as a potential anticancer therapy. Go to Contents Page 3 • Research

FACULTY FEATURE: Robert S. DiPaola, MD Edmund C. Lattime, PhD Director Edmund C. Lattime, PhD Deputy Director and Associate Director Edmund C. Lattime, PhD , is the deputy director at The Cancer Institute of for Education and Training New Jersey, as well as the associate director for education and training. He also is a Joseph Aisner, MD professor of surgery, director of surgical oncology research and professor of molecular Associate Director for Clinical Science genetics, microbiology and immunology at UMDNJ-Robert Wood Johnson David A. August, MD Chief, Surgical Oncology Medical School. Linda Barker r. Lattime is well known for his work in When recruited to CINJ in 1998, Dr. Lattime and Chief Administrative Officer and Associate Director for Administration tumor immunology. His laboratory studies colleagues continued building on these previous and Planning Dthe interaction between the tumor and findings. They completed a first-in-human Phase I Joseph R. Bertino, MD immune response with the ultimate goal of devel - clinical trial sponsored by the National Cancer Chief Scientific Officer oping effective immunotherapeutic approaches. Institute (NCI) Cancer Therapy Evaluation Program, Kevin Coyle Executive Director of Finance During his postdoctoral fellowship and subse - which focused on the treatment of advanced blad - quent ten years as a faculty member at Memorial der cancer tumors with a human-engineered Richard Drachtman, MD Interim Chief, Pediatric Sloan-Kettering Cancer Center, Dr. Lattime carried fowlpox virus. Most recently, Dr. Lattime’s laborato - Hematology/Oncology out the defining studies into the identification and ry has identified the effectiveness of intratumoral Susan Goodin, PharmD, FCCP, BCOP regulation of natura l cytotoxic cells shown to have immunization with a related vaccinia-based tumor Assistant Director for Clinical Science significant antitumor activity. Also at vaccine. Teaming with the CINJ John J. Graff, PhD, MS Chief, Bioinformatics and Sloan-Kettering, his laboratory Gastrointestinal Tumor Study Group, Surveillance and Director, began studying the interaction they have translated these latest New Jersey State Cancer Registry between tumor and the immune findings to an innovative Phase I Bruce G. Haffty, MD response in patients with bladder study, also sponsored by the NCI, Chair, Radiation Oncology cancer. These studies identified the where patients are immunized Isaac Yi Kim, MD, PhD Chief, Urologic Oncology tumor microenvironment as a target directly into the pancreas using an Sharon Manne, PhD for therapy. In the late 1980s when engineered poxvirus containing Chief, Population Studies K

he was recruited to Thomas i m tumor markers (antigens) expressed Guna Rajagopal, PhD S o

k Executive Director, Bioinformatics Jefferson University, Dr. Lattime used o on pancreatic cancer. Early results of l o f data from these clinical and pre- f this study, presented this past Lorna Rodríguez, MD, PhD Edmund C. Lattime, PhD Chief, Gynecologic Oncology clinical studies to further explore the November at a national scientific modulation of antitumor immunity via drug/gene meeting showed that in four out of six participants, Roger Strair, MD, PhD Chief, Hematological Malignancies/ delivery to the tumor microenvironment. the direct-injection vaccine treatment was shown Hematopoietic Stem Cell Transplantation Building from this work, his group ultimately to be associated with clinically stable disease (see Deborah L. Toppmeyer, MD developed a genetically engineered version of the page 5) . Chief Medical Officer Chief, Solid Tumor Oncology smallpox vaccine virus (vaccinia) containing the gene While research is a main component of his work, Eileen White, PhD for GMCSF – a substance naturally produced by in his role as Deputy Director at CINJ, Lattime also is Associate Director for the body’s immune system that stimulates immune responsible for the Education and Training Programs Basic Science recognition. They took the virus from preclinical at the center. This includes, The Governor’s Conference Helmut Zarbl, PhD, ATS validation to the genera tion and regulatory on Effective Partnering in Cancer Research, which Associate Director for Public Heath Science approval of a human grade virus used in their was started in 2003, with the goal of raising the first-in-man study in melanoma. The virus was visibility of cancer research in New Jersey, and the

patented and ultimately licensed to the Jennerex Annual Retreat on Cancer Research in New Jersey, is published by Biotherapeutics Company. It is currently in Phase II/III which brings together cancer researchers from CINJ’s Office of Communications. study in patients with liver cancer. Most recently, across the state to present their findings and build If you would like to be added to or removed from the mailing list please results from a Jennerex clinical trial of the virus was statewide collaborations. He is also responsible for contact us at 732-235-9871 or the focus of a publication in the journal Nature overseeing Faculty Affairs at CINJ. [email protected] . demonstrating for the first time a gene therapy Candace E. Botnick, MS given intravenously that localized and preferentially Dr. Lattime’s research is supported by grants Director of Communications targeted tumor metastases. from the National Cancer Institute. Copy: Michele Fisher Design: Barbara Walsh Graphic Design 4 Go to Contents Page reatment

T 5 s , is f ent y pox l or m b ent ch into which te had tsel 5 other that re- ow i he ient ati that ed um 1 or t eatm wo F t on. ery, p sys r t ee vaccine at whi w ng y) dy, t , shown r es o no er p r y ond a t vi h une um pl ected e ive and d mor V, ft ne urg t t it ox l cancer r accine wo r stu ressi ec ei s tional a F ollo ft c u , m ere v s a f en g T tu lp inj a s e io her (a ulti of xi di t d . w r t e m e on se rec C- al y ro eived gh im e, o is d th o p as e . giv additiv er m t ll nia A a p d r u und. an m c ea ) m f , onths c ien i ec a in t e er re Th r s o o t y r s whose ecti e t o is an n C-F tu b l , r NVAC- a s m cci ’s en s an s d ng a ing fo a A af NV d still t io p Th c e se th inj es t ea it e gene um va ely. n the op A iseas PA r – ltip b t – a c panc 12 t. h a is ed i i s P iv pr ultraso u t ble u ien crui t e e t d ns a d pants can vel ect a pha er en e D ved h ANV t at a fo emc m person are ic ac c en in eat ir of t d s r the m P g p lua r de b th d g a pec e a . is m tm rus kened sease. pi rus r d an ro i i h of ta f first a nc l lly c in artici es onths, emo u n not i v vi ag ev ea r di r nd a a r contai nd er. p a n rm who s o ia into ate c a c e m p l f e reg tr a e i s a wea wit i o o e he ed ft ai tr t s, u t he r a uring t e b d 3 at th n can ne emc th t d six in s i m e ov e d u l he t 1 t e r on on m g o endoscop fo e n wer and sam r t e he i c t b Stable o u nize b e VAC n o ng t r ti at ti c si o h t m a s a d e h d st t s pant e n a a n rs ing t t hat e e e i e N e hs, og e t he gh r v e m s f n n an n uri rm of i t ci iv tr h d ici A k iv l e k tm a ht n l p e t e ec nt gr t t h ci ci i r O e oug ha ean D e r e P a r g us r r t u c c o p f a a r c as e e e v a ir o o r hr he o pa pa nine mo t t va c w va fo re O w w m pr pa c looked t t v gi (m is uses sponse t mi with s s e - es in an fic y. c R- c y e y’ d a p c dy he t e . e ti t d i s y om u t in va - i eci t ka e: Treatment o ger in C c fr AC g th c n st r s er. s r eas b c un i ha nd sp e n a c s o o s A peu lt t e INJ ew i loc a t su e c h a n VA m va u ng th ki t r d b two ssociated a mo h C N or- in c ell wa g eren t o he iven c es N m Th u f ne or t al n ine g ts f t i r le t mi g t i f w A s lo . a a ne o n n a t gs es s c ein b s n Ther ht n u on s PA a cc um t ab . tum h u zi e er es th a t io b n e. fi g a t t o f em t a r t nes t t i i C s t c m o l er is v o r fi er acc f l t ili a co d as u er i nc t S ed a s a a or t l ec o ga d h tut t i – a a it m i al ta o i g i V ut her nc n h ri i t th r t c s ia t ti t n a wide d. t sp g st l ien jec by en w in it o en l wit e ns re nd f ra anc t ic C n ns tum ea fur I sc al v a tio i d o na ent es I tin skin no l ca – d ica Fr tem ic t e duc in te rs k pres Canc s er ed e rs na pr t spr ted n by epos reat n jec body- e n itio pot e a o in ina c cer to or en elf d sy li er th ly nc c clin t in n c to cia is e pro ge ig a ch Sa th ter f c e ad ies its r o s a a ets o In esign s th Pa C ar tr tiga at pan ent o jection va upp s Th in Can of d e un are ity- c s cer s rg is po mall e a e a of tud e th l s as a s s es r o of nt y, he e i ld site h an In is h o th or. T velopm t ts n g R t s c Th b l umor na inves te f r RTC rc k re us y e t imm he a th mun m t ul o wh te de ing e r o in of o s ancreas a ri a on f to ea o g ti n e tu at e we ula s er y ts C th how vi o im NJ re tr al s P ion d c s c w n n th e s in s e unit tl n -EO t y th e r re e o e t r y rect I n ow c e t s Na l t h s e e CI e us i e r e s Pr a t e di se rl d mi t u c e o n r c i a a av uc th a ir row i a l n hi ev o o r e how mm G c by f t c e g i t a r t a o h me Mo NC J d E p s d fo Di th Thi A s l e r o y a n e. es se re u. to t er of of at e o nt er. ng on ve. nts nts th u are als, ent ls@ s di su ls ri visit ve nc n ey tha ers nsive stat tie ia ce rs j.ed rs ancer J tri k tm ia re e bout stu ca e n 675 l he C p clinica ways cancers. l_trials, a atment atme tr pa ltr numb l ake is ea ding or effecti atio art, th Office e -8 ew re l a r ca of tr p a ca m to h c er s t ea m tre tre to Servi arche arche N l uncove f umd g tte nd J' Th o rc e g h o ions nc se se orm ys t ke ou reatment 235 a d ion is t f rious of a clini ew be st t inica ar in comp re rch c IN e ta l sea J Re medi 2- e jclini c n in wa va r c nd J g dyin Wit ods C ugh t re o st war t a in ut ive sea to saf e que l 73 er re w t org/clinica er. T c th es even ro exist c t to are stu c t al CIN tit is al Re w • er Mo ac ew rea ne g hes CIN c th pr t y il: ls t ic mo t t me an l A n inj. an ns ay i n a c 0 ho c I d r of ia men .c rovidin w nt w lin tha n nsw nd e usin p tr c 14 nd -m at a a Fo r a e ne for a ww tre ur w Huma c • Treatment

Building a Better Predictor Robotic Surgery

eveloping technology that is and Gynecologic Cancers designed to predict how Daggressive a common form of breast cancer is likely to be, is getting a A gynecologic oncologist at The Cancer Institute of New Jersey, boost thanks to a National Institutes of Mira Hellmann, MD , is specially trained in the area of robotic surgery. Health grant. Cancer Institute of New Utilizing the tiniest of instruments, Dr. Hellmann, who is also an assistant Jersey member Anant Madabhushi, PhD , and Ibris, Inc., which is a start-up professor of obstetrics, gynecology and reproductive sciences at UMDNJ- company co-founded by Dr. Madabhushi, Robert Wood Johnson Medical School, operates in fine precision through the use of controllers has received a one-year, $207,000 award on a console that is steps away from the patient. to develop a quick and economical analysis of tissue from breast cancer What is What are the benefits of biopsies. robotic surgery? this procedure versus Madabhushi’s technology examines a Q: Q: traditional surgery? high-resolution digital image of biopsy specimens, using computerized image Robotic surgery is a form of analysis tools to reveal difficult-to-discern A: minimally invasive surgery There are several, but one of characteristics that indicate the disease’s (similar to laparoscopy) that utilizes the A: the main benefits is patients grades of severity. It builds on earlier assistance of a “robot” to increase the ease experience significantly less pain post oper - research to detect and grade prostate of the surgery. The instruments are inserted atively and therefore recover faster. This cancer by analyzing magnetic resonance into the patient via very small incisions — usually allows the patients to leave the hos - images of the gland. a centimeter or less in size — then attached pital after only one night’s stay – compared “Each year, about 120 thousand to a robot. The precise movements of the to the routine three or four nights in the hos - women in the U.S. and a million women robot are controlled by the surgeon pital. worldwide are diagnosed with estrogen- through controls present on a console, receptor positive breast cancer,” said usually located in the same room, directly • • • Madabhushi, who also is an associate at the patient’s bedside. professor of biomedical engineering at Is everyone a candidate for Rutgers University. Those with less • • • Q: robotic surgery? aggressive forms of the disease may respond solely to hormonal therapy, What are some Unfortunately, not everyone is typically tamoxifen, but those with more examples of how this Q: a candidate for robotic surgery. aggressive forms will also require method is being used to A: Consultation with a robotic surgeon is chemotherapy. treat gynecologic cancers? necessary in order to determine who is and “By determining how aggressive the who is not an appropriate candidate, as tumor is, we can help those with less The technology is used many factors are considered, including type aggressive cancer avoid chemotherapy for lymph node dissection, of cancer and general health of the patient. with its side-effects and expense, and at A: radical hysterectomy, radical trachelectomy, the same time, we can help those with and complicated hysterectomy (including • • • more aggressive cancer get immediate pelvic masses). Therefore, women with access to the treatment they need to CINJ’s entire team of gynecologic endometrial and cervical cancer (and oncologists is trained in robotic surgery and fight the disease,” he said. pre-cancer) are primary candidates for this has performed more than 100 of these CINJ medical oncologist, Shridar type of surgery. In addition, women with procedures within the past year. To learn Ganesan, MD, PhD , who is an ovarian masses, and/or early stage ovarian more about robotic surgery or CINJ’s assistant professor of medicine and cancer may benefit from this surgery Fannie E. Rippel Center for Women’s pharmacology at UMDNJ-Robert Wood Reproductive Cancers/Gynecologic as well. Johnson Medical School, is the clinical Oncology Program, call 732-235-2465 principal investigator for this project. • • • or visit www.cinj.org. 6 Go to Contents Page revention

P 7

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Outreach Director ‘Jersey Girl’ Study at CINJ Tapped for at CINJ Looks at Understudied National Program Hormone Disruptors iameesha Evans, MPH, MCHES , program director of the Office of shown in studies to increase the risk K Community Outreach at The Cancer of breast cancer. The Jersey Girl Study , Institute of New Jersey, has been selected to which aims to examine factors affect - take part in a unique pilot program for cancer ing puberty in girls and is based at control practitioners The Cancer Institute of New Jersey, through the National has shown that estrogen- like sub - Cancer Institute. stances produced by fungi may act As one of only six as a hormone disrupter. participants selected Led by CINJ epidemiologist Elisa nationwide, Evans is taking Bandera, MD, PhD , a multidisciplinary part in the Research to team of investigators recently found Kiameesha Evans, Reality (R2R) Mentorship detectable levels of these fungal com - MPH, MCHES Program for one year. pounds, known as mycoestrogens, in The R2R Program aims to strengthen the urine samples donated by girls par - ability of public health professionals to effec - ticipating in the Jersey Girl Study . The tively navigate and execute evidence-based findings suggest that the presence of cancer control and prevention interventions in uberty is a time in a girl’s life these mycoestrogens may delay community or clinical settings under the considered highly sensitive to height growth and the onset of guidance of a mentor. Pstimulation by the hormone breast development in young girls. As a mentee, Evans will work with Evelyn estrogen and a critical window dur - The findings were published in Gonzalez, MA, from Fox Chase Cancer Center ing which estrogen exposure could the November 15 print edition of on the implementation and evaluation of the greatly influence the risk of breast the journal Science of the Total Body & Soul Program. The program will provide cancer later in life. An early onset of Environment (doi:10.1016/ resources such as healthy recipes and exercise puberty also has been consistently j.scitotenv.2011.09.029). DVDs to leaders at New Jersey houses of worship to help them build awareness of healthier living within their congregations.

Another Successful Prostate Cancer Screening Event

he Cancer Institute of New Jersey and its Flagship hospital Robert Wood Sharing a Survivor’s Johnson University Hospital (RWJUH) reached a significant landmark in Moment Ttheir annual prostate screening event this past year, having tested more than 700 men over a three-day period. This figure surpasses the number of attendees who participated in previous years and brings the total number of men checked over the past s we look ahead to five years to around 3,000. A our National Cancer CINJ urologic oncologist Thomas L. Jang, MD, MPH , who led the clinical compo - Survivors Day celebration this nent of this year’s screening, noted that the best available studies show that screening June, we at The Cancer men for prostate cancer saves lives. “The goal is to find aggressive cancers that are Institute of New Jersey want potentially curable at an early stage, so these men can have a successful outcome while to thank all of those who limiting over-detection and over-treatment of less harmful cancers,” said Dr. Jang, who is shared the story of their personal journey with also an assistant professor of surgery at UMDNJ-Robert Wood Johnson Medical School. us at last year’s event. The segments, “Sharing a Survivor’s Moment,” are now available at This screening was funded in part by a special gift from the Robert Wood Johnson Foundation www.cinj.org/SurvivorsMoment.html. and co-sponsored by Panera Bread.

8 Go to Contents Page • Inside CINJ

Kudos!

usan Goodin, PharmD, FCCP, BCOP , Sassistant director for clinical science at The Cancer Institute of New Jersey and professor of medicine at UMDNJ-Robert Wood Johnson Medical School, recently received the Distinguish- ed Service Award at the 2011 American Society of Health- K i m Systems Pharmacists Midyear S o k o l o Clinical Meeting. This award f f spotlighted her volunteer activities and contributions which supported the mission of the Section of Clinical Specialists and Scientists. Dr. Goodin was one of six individuals to receive this prestigious honor.

ruce G. Haffty, MD , chair of radiation Boncology at CINJ, and chair and professor of radiation oncology at the I UMDNJ-Robert Wood Johnson

Medical School was recently n s

recognized by the New York i d

Roentgen Society at its 2011 e S t e C v e

H Annual Meeting for his vast I On Tour o c N k s t

e contributions to the radiation i

r. Guna Rajagopal (bottom, far right), Executive Director of Bioinformatics J n Dat CINJ, recently gave a tour to several students involved in programs at oncology field. the Center for Discrete Mathematics and Theoretical Computer Science (DIMACS) at Rutgers University. The students, who are studying how math, science and computers come together to measure and analyze large data sets, had a tif Khan, MD , radiation oncologist at chance to visit CINJ’s zebrafish lab, as well as the radiation oncology clinic. A CINJ, and assistant professor of radiation oncology at UMDNJ-Robert Wood Johnson Medical School, was named a recipient of the 2011 Educator of the Year Award. Sponsored by the S t e v e

H American Society for Radiation o c k s t

e Oncology and the Association i n of Residents in Radiation th Sa We hope you’ll e D ve Oncology, this award recognizes outstanding join us for our 2012 at teachers and mentors of radiation oncology Survivors Day Celebration: e! students. K

i “iThrive...iSurviv e” m S o k

o When: Sunday, June 10, 2012 l o f f Where: CINJ Breast cancer 195 Little Albany Street Follow us on survivor Dorothy Reed New Brunswick prepares to go Facebook: Become a “fan” of CINJ’s Facebook page at on camera. Visit www.CINJ.org/survivorship www.facebook.com/TheCINJ or go to www.cinj.org for more information. and click on the Facebook icon to get started!

Go to Contents Page 9 • Inside CINJ

CINJ NETWORK potlight : New Treatment and Support Services at Steeplechase S Cancer Center

omerset Medical Center’s Steeplechase SCancer Center has launched a specialized Lung Cancer Clinic dedicated to the early diagnosis of lung cancer. Low-dose CT scans are offered for current or former smokers over 50 years old with 30 or more “pack years.” Results are evaluated by a pulmonologist The Steeplechase Cancer and patients with positive Center recently received a grant findings have access to the from the Central and South cancer center’s Lung Cancer Jersey Affiliate of Susan G. Institute, a multidisciplinary Komen for the Cure ® to pro - team of specialists that mote annual mammograms includes pulmonologists, among older women. The cance r oncologists, a nurse navigator center also promotes annual and thoracic surgeons. screenings among medical cent er

New Leadership for CINJ Hamilton

oard-certified oncolo - Johnson Medical School started advanced cancer therapies, and gist and hematologist more than 13 years ago – first patient-physician com munication BBiren S araiya, MD ’02 , as a medical student and resident , makes him the best choice for (left) of Lawrence ville has been then as a hematology-oncology developing CINJ Hamilton into named medical director of The fellow, and most recently as an the “premiere, patient- centered Cancer Institute of New Jersey assistant professor of medicine. cancer program in Mercer Hamilton (CINJ Hamilton) – For the past three years, County.” the oncology program at Saraiya has also served as a mem- “I’m excited to help expand Robert Wood Johnson Univer- ber of the Thoracic Oncology the current infrastructure and sity Hospital Hamilton (RWJ and Hematologic Malignancies services offered at CINJ Hamilton). Programs at The Cancer Institute Hamilton, and I look forward “I view this position as an of New Jersey in New Brunswick. to collaborating with my col - oppor tunity to give back to the According to Skip Cimino, leagues in New Brunswick to community in which I live,” says president and CEO of RWJ develop a more integrated pro - Dr. Saraiya, whose association Hamilton, Saraiya’s research and gram here in Hamilton,” noted with UMDNJ-Robert Wood expertise on end-of-life care, Saraiya.

10 Go to Contents Page Inside CINJ 11 e g k; a or P its over , or , w s are t ion ect n hief , or Net hief C e t C Dir , or , , , t ect , , ations Radiat al ion ec ief ief CINJ healthc , n o C Dir ir h h , MD , air ic ic C C linic D PhD or o t h t , , essor C ogram , adiat -art public C atulate congr , o , R of ec Pr of , MD s G of , – y Pr u to or opoiet opoiet Dir e MD or PhD PhD of MD, o e MD i , m sor MD iat u MD or ess e ik olog iat T l ion r a v fes oc of Oncology oc MD ess MD, MD, Hemat Hemat of of f n / / Pr Onc i Pro Ass , yer oppme T t - state-of-the Ass Solid ion , Kearney ies ies Pro MS Radiat ue , c c y l h t n o M L. Goydos, , fty Haf would ive 1 1 0 2 iat f d INJ; of INJ; Gibbon, J. essor essor s r e e iss ief and INJ; istan o C ” C T p h ad an RWJ of of , Jabbour S. C t , Strair , Strair or Rodriguez, Gabel, , y G. - MS R C , y r , y s , UMDNJ s Pr Pr g Ass g f g oduct , CINJ d i e ; ; alignan alignan ; es es provide y o WJ Soft f lo hair p lo y e s r e J men g olo R t M M o h t o an o C d INJ INJ or lo o ; ec ar Repr Pr y C C CINJ al al o er UMDNJ an Darlene Roger Thomas Lorna Roger Deborah Molly James Bruce Salma S b , , , Servic e d Onc ess , Onc ic t DNJ- INJ f a gic gic M Jersey I I I I I I w e N r e b m e v o N I I I I Gyn Dep MS C J o “T ic an ic ion ion Onc m ery lo lo gis , , ciat Off are . patients , y UM y Pr o g o o W o n lo WJ C r h c u s tat tat gy log s log R ew al o , y at at rics t io o d o -R c log lo ic Su N , As lan lan olog n iate s a o ec f tet ec ; em em c c eas their O n o ief n Melan sp sp r olog r of eco o n H H S y S adiat y te s B Med d e INJ Onc O s to R ; ; an an G to Obs Ch G M ion ief C r r S S UMDNJ- sor J JM A f , r S n UMDNJ ief, Onc T T Gyn ec h , al al , o t o v o INJ INJ M M of , iat h io im C J J n ic ic , r fes s, t C C gy JM C r o V ell ell Dir , es g g o ery , er ad -RW -RW io , , ect ic iat , c lo C C t r g en so R e cated Pro 2011 r o or or i ief Institute In -RW -RW iat ect t t ad c et Sur Sur Dir m ; -RW es e r e w s ien h d t iat t , f r MD R n , , Su , em em s c , air sor ec ec e ad C o Dir PhD o Sc ar f O b INJ o h R St St d ce , ief ief s , o h Pr C UMDNJ C O UMDNJ e Dir Dir n h h ep y MD and and of an , , MD w , , As C C Program, D tiv e, UMDNJ UMDNJ poietic UMDNJ , , , Ca c Profes gy ssl ” o y or MD or PhD of in MD, , , y , y f e, e, e s g e lo s October e l r ; at ic ams ams m du MD o MD MD e o er er in in lo h es u o . s c r c – re f gr gr so MD g g MD MD T r T o ic ic sici ciat o n of o o o ti t s th CINJ es o Med MD, S Hem ep r ien O octors f s Pr a lid Pr Pr Sur Sur – R es o , y Onc , oppmeyer T re D ; M f f f on Sc Med Med y y e J hy g As So , Kearney ies/ a o o o Pr e g g al c m ; esso L. lo INJ WJMS u W r r Goydos, iat f , fty Haf Pr d d op ic tors J. s P o c of C R R o o Drachtman, S S an ; Living olo olo n ief, , Aisner , Aisner DiPaola, DiPaola, o uctive , r c c 2011 n lin an S. h “T oc a , Strair s MS Pro y is T August, August, Rodriguez, CINJ M M G. d o MS J ess ess few C J J INJ C g ; J s t , f f Onc o e, J Jersey / As On On r r DNJ- C air W o o alig lo d y es W es st , r r h INJ R f o RW RW fo g Sof Pr Pr R ep a M e, o o ic - - icin c C C o an f f r UM c ; ; R p lo d ; Savvy , o Pr IN ed o t d , y er Robert Deborah Joseph David Thomas Lorna Roger David Robert d Richar James Bruce Joseph MD On e INJ; DNJ- INJ INJ ical DNJ DNJ ien an Serv e DNJ- S INJ at S M ic ion h C er ec g C C f ic an I I NJ I I I I I I I I I I Inside October I C t C a f Sc D g M Dean Dean M g at lo r y J UM o J , y , y e, t UM UM ciat m Of Dir UM are , y o e e al g lo c , g g r o o Hem S g C e e W s Su W o s ic , y o al lo lan lo lo R t R iat iat s f ic lo ic g - ien o - o o ic r c c ec JM r As o lin o sp icin icin S S es lo o o ; Sc C ec r f eas s s iat W o iat Hemat r n o an ed ed r Melan S R JM JM Onc Onc r S s Gyn B Med - Onc INJ As As T Pro M M fo M Gy Ped C M W W Ped J MS Onc f f J fes UMDNJ UMDNJ , J R R f ell o o - - , y o DNJ , n W o W C g W r r ics e, R Pr r R io r - R o o - ery lo ; o in - s s UM DNJ DNJ et s g o iat ic t r es es INJ es f f Stem f ad UM UM Su C R Onc Obs f Med Pro Pro UMDNJ o Pro UMDNJ UMDNJ , e, e, in es in c ic ic ien Med Sc Med it n vis m o c . a in h t ter en C ’ ts l ay r e t n e e d about e r o ien u f s , ter en C urs ed s m s e e l echase on n am pat u c c o cer an C gr g epl p u o d e n u s o tiq dicat e tw se r g a tin m rmati te S de ine can edica M d e r c ee e , er nter i Bou a s r t o r am t c r e c n a c e s a h c e l m info k r ce dic l e h Th m wo o ted ess t

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Award of Hope Gala Brings Promise

he 2011 Award of Hope Gala was a wonderful Tcelebration of all that makes The Cancer Institute of New Jersey great! Three terrific honorees and an inspiring young philanthropist were applauded by an appreciative crowd of nearly 400 CINJ donors, P

supporters, patients and well- h o t o s b

wishers. y K y o

As they were seated in the ball- M o r i s h

room at the Hyatt Regency New i m a P h

Brunswick, guests celebrated the o t o g r a

outstanding contributions to p h advancing cancer research and y CINJ’s Dr. Roger Strair sports his Century for the Cure jersey as he presents hree terrific honorees Aileen and Scott Glickman their Award of “T Hope for Philanthropic Leadership. and an inspiring young philanthropist were founders of the Century for the applauded by an apprecia- Cure annual bike ride. Scott and Aileen created the ride as a way to tive crowd of nearly 400 give back to the institute that saved CINJ donors, supporters, his life and to fund research so patients and well-wishers.” others may have better treatment options in the future. The amazing sion and humility that are hallmarks efforts of this couple have resulted of this incredible couple. in more than $825,000 for cancer Finally, guests were introduced to research and programs at CINJ since an outstanding young man, Dan 2004. Scott and Aileen’s heartfelt Hertz, who received the Young acceptance underscored the compas- Philanthropist Award for his efforts to bring awareness Long-time CINJ treatment that have been made by to and raise funds supporter Award of Hope for Leadership in for cancer research Val Skinner (left) Research recipient, Eileen P. White, while at Rutgers with CINJ’s PhD Dr. Eileen White, , who is associate director for University. He recipient of the basic science at CINJ as well as a described his Award of Hope professor of molecular biology and motivation to for Leadership in biochemistry at Rutgers University. become involved Research. Dr. White’s groundbreaking discov- with a poignant eries have translated into the devel- recollection of his opment of new cancer therapies and mother, in her mid- novel clinical trials for patients. thirties, taking his A special video was then shown highlighting Award of Hope for CINJ’s Dr. Susan Goodin presents the Young Philanthropic Leadership honorees Philanthropist Award Scott and Aileen Glickman, to Dan Hertz.

12 Go to Contents Page Training Future Breast Cancer Surgeons hand as an eight-year-old child and pressing it against a lump found in ighteen months ago, Dr. Naik is eager to share his her chest during a routine physical. Archit Naik, MD, clinical research focus, stating, She passed away four years later in EMBA, submitted his “I recently submitted an abstract 1996, not knowing whether her breast application to the Society of to the American Society of cancer and cancers in her mother Surgical Oncology (SSO), Breast Surgeons researching and grandfather were connected. the organization which the role of post mastectomy Dan noted that today her story Invited to “purchase” reviews and pproves radiation in research minutes, would be quite different – advances guests bid with surgical fellowship patients with three in prevention, treatment and patient extraordinary training programs or less positive care now provide young mothers generosity, raising in the United States lymph nodes. more than $75,000 and conducts a The project was who find a lump with more options in a few short, but and hope. Dan’s commitment to very memorable Matching Program conducted with fighting cancer didn’t end when he moments! to match qualified several different candidates with departments, SSO-approved including medical training program. oncology and Of the outcome, Archit Naik, MD, MBA radiation oncology.” Dr. Naik, the C.R. Bard Fellowships like this are made Surgical Breast Oncology possible through the generosity Fellow, says, “After six of donors who recognize the months, I feel that I could not importance of training the have matched at a better place next generation of physician- than The Cancer Institute of scientists. In describing the New Jersey.” fellowship experience made

The one-year fellowship at possible by the investment of I CINJ provides surgeons who C.R. Bard, Inc., Dr. Naik notes,

have completed their general “I enjoy working with all the n s i

surgery residency with advanced attendings of CINJ. They are d training and experience that all from different training e t

prepares them to provide state- backgrounds, which makes CINJ h e left Rutgers with a PharmD from of-the-art care specifically for an invaluable place to learn the C the Ernest Mario School of patients with breast disease. intricacies of breast surgery.” I N

Pharmacy. He is currently a third Through the program, they In fact, the surgical breast J

year PhD candidate at the University learn how to apply a multi- oncology fellowship at CINJ F o

of North Carolina, Chapel Hill, disciplinary approach to the is one of the most desirable u continuing his education in trans- prevention, diagnosis, treatment placements by SSO. In 2010, n d lational oncology pharmacoge- and rehabilitation of breast over 70 candidates applied a t i nomics research, with a specific cancer patients in a compas- for positions in 32 approved o focus on breast cancer. sionate manner. In addition, programs and CINJ received n Dinner, dancing, a live auction and CINJ fellows participate in 41 applications for the one the unveiling of CINJ Foundation’s clinical and/or laboratory available position. newest video, “Spectrum of Hope” research with opportunities to wrapped up the evening. Visit design and implement clinical www.cinjfoundation.org to view protocols, and train in basic the video, which underscores the methodology for conducting mission of CINJ. clinical trials.

Go to Contents Page 13 • Inside the CINJ Foundation

New Trustees Join Board

he Cancer Institute of practiced healthcare law extensively Michael E. Lubowitz, Esq. New Jersey (CINJ) during her career. She currently The co-head of Weil, Gotshal & TFoundation has named serves as a member of the Horizon Manges’ New Colleen D. Brennan and Michael E. BCBSNJ Corporate Compliance York Private Lubowitz the newest members of and Integrity Program and as Equity and its Board of Trustees. Assistant Secretary to the Board of Mergers and Directors for Horizon BCBSNJ Acquisitions Colleen D. Brennan, Esq. and its subsidiaries. Brennan also Department, Colleen D. held positions as Vice President, Michael E. Brennan is a Legal Affairs; and Deputy General Lubowitz is a Vice President Counsel at Horizon BCBSNJ. noted attorney, and Chief In these roles she advised senior representing public and private Compliance management on legal and companies in a broad range of Officer at regulatory issues relating to transactions. Lubowitz has advised Horizon Blue insurance, health maintenance clients that include CBS Corpora- Cross Blue organizations, and pharmacy. tion, C.R. Bard, DIRECTV, Shield of She previously served as Assistant Lehman Brothers, and Verizon Inc. New Jersey (Horizon BCBSNJ), General Counsel at Prudential among others. Lubowitz is an which serves approximately 3.6 Financial, Inc., and as Counsel active participant in various pro million members. Brennan has at Aetna, Inc. bono and not-for-profit matters. Various areas of participation include providing counsel to youth organizations, services to Holocaust survivors, and counsel to an Iraqi citizen who provided valuable On the assistance to the U.S. government.

Road to Subha V. Barry , chair of the CINJ a Cure Foundation Board of Trustees says the two newest members will be great assets to the CINJ William Foundation. “The extensive health Ballinger (front row, second from and business law expertise from right) , President Ms. Brennan and Mr. Lubowitz of Allstate New complements the vast collective Jersey Insurance Company, and experience held by our Board. the team of In propelling the CINJ mission Allstate agents of conducting ground-breaking from around the state present research, providing innovative a check for $50,000 cancer treatment, and facilitating from their “Quotes prevention and education for a Cure“ pro - programs, these new members gram to support research, treat - surely will help make an impact on ment, prevention that progress.” and education programs at CINJ.

14 Go to Contents Page Students and Communities for a Cause

he inaugural Golf for a helped me to get where I am Cure , sponsored by Nutley today, CURED!”…Despite THigh School Football the September rain, support - Alumni, brought together 55 people ers gathered in Roosevelt Park to raise $13,000 for prostate cancer in Edison for the 3rd Annual research. Understanding why the Pancreatic Cancer Walk lead people of Nutley came together is by the Mayor of Edison, just as touching as the tremendous Antonia Ricigliano; Acting efforts put forth by event Clockwise organizer Mario Cocchiola, from Above: who was treated for prostate Members of the cancer at The Cancer Insti- Roselle Catholic tute of New Jersey. Grateful Volleyball Team. for the incredible care he Piscataway Cheerleaders received, Mr. Cocchiola Marissa Nagy wanted to support CINJ’s (left) , Amanda efforts to find a cure, as well Stasyshyn (center) , and Rebecca as provide the community the Director of the Stasyshyn (right) opportunity to remember Nutley Middlesex County which included a present checks head football coach, Sandy Phillips, Office of Public bake sale, gift auc - at CINJ. who led the school’s football team to Health, Katherine tion, and a pumpkin Denim Day event its 1960 state champ ionship and lost Antonitis; and organizers Janet decorating contest – Gonzalez (left) , his battle with prostate cancer…A Chairperson from raising over $2,000 Barbara Lemley crisp fall Saturday provided the back- the Middlesex to benefit cancer (center) and Debbie drop for the neigh bors of Sayerville County Committee of Public Health research. During the past year, three Rubio (right) . I to join in the Leprechauns 1st Cancer and Education, Carol Barrett Bellante . employees were diagnosed with can - “Go Jane Go” participants take Walk . The Sayerville Leprechauns The walk raised more than $2,500 cer making this event even closer to a break on the n s

Football and Cheerleading Associa- for pancreatic cancer research at CINJ. home… Roselle Catholic High boardwalk. i d tion spearheaded the effort which had Special thanks to ParamCARE for School held its 4th annual Spike e t hundreds of supporters gathered to helping to organize the event… St. Breast Cancer volley ball tournament h take steps forward towards a cure… Joseph High School in Metuchen in October. With the Central Jersey e After celebrating her sixth year as a was rocking and rolling in October C Police and Fire Depart ment enter - I breast cancer survivor, Jane O’Brien to find a cure! The Student Council taining the roaring crowd with their N J thought the time had come for her, sponsored a record-setting concert

drum band, the Roselle Catholic F as well as others, to give back to those featuring “Audio Insight” with alumni varsity team defeated its rival Bishop o u who spend day and night searching band members Anthony Celi, Mike Ahr. According to coach Jamie n d for a cure at CINJ. This past October, Deverin, and Dan Sullivan. Tickets Godfrey, winning was just an addi - a t

Jane rallied her closest family and were $5 each and all proceeds went tional benefit to raising money to i o friends to join her in the “Go Jane to support cancer research at CINJ… fund breast cancer research at n Go” breast cancer walk in Bradley It was more than just a casual Friday CINJ... The Piscataway Braves Pop Beach – raising more than $1,500 when employees at DiFrancesco, Warner Cheering Squads took their dollars. “My doctor and team are Bateman, Coley, Yospin, Kunzman, spirit to the stands on a Saturday in great – there are none better. They Davis, Leher & Flaum in Warren cele - October to collect $400 for breast explained all that was happening to brated Denim Day . Employees contri- cancer awareness and research me while I was receiving treatment. buted $5 for the privilege of wearing (including a gift from the Piscataway I walked to thank all the people who denim and participated in activities Braves Parent’s Auxiliary).

Go to Contents Page 15 Non Profit Org. U.S. Postage PAID 120 Albany Street CINJ Foundation Tower Two • Fifth Floor New Brunswick, NJ 08901

• Inside the CINJ Foundation

A Giving Spirit at Exit 109

here’s nothing like coming ‘home’ for the holidays, and Tthat’s what a number of the Garden State’s most notable musicians T h e C

did recently in performing a special o u n t B

concert in Red Bank to support the a s i e T h

incredible work being done at The e a t r Cancer Institute of New Jersey. Under e the musical direction of Jersey Shore From left: CINJ Foundation Board of Trustees member Ed McKenna accepts a $175,000 check from Bobby Bandiera as Q104.3 radio personality Ken Dashow looks on. notable Bobby Bandiera and headlined by Jon Bon Jovi, the Hope Concert services to the cause. Bandiera and the Tim McLoone and the Shirleys, and featured a cast of the state’s finest musi - Jersey Shore Rock-N-Soul Revue, others served up classic hits to an cians, who – along with the host venue, Bon Jovi, Southside Johnny, Gary U.S. audience of about 1,500 and helped the Count Basie Theatre – donated their Bonds, Nicole Atkins, Brian Fallon, raise $175,000 for CINJ!

16 Go to Contents Page