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Public Version Filed: February 14, 2019
EFiled: Feb 14 2019 05:12PM EST Transaction ID 62972723 Case No. 2018-0740-SG IN THE COURT OF CHANCERY OF THE STATE OF DELAWARE IN RE OPKO HEALTH, INC. ) Consol. C.A. No. 2018-0740-SG DERIVATIVE ACTION ) CONFIDENTIAL FILING VERIFIED CONSOLIDATED DERIVATIVE COMPLAINT Court-appointed Co-Lead Plaintiffs Jamie Gewirtz, Emily Gewirtz Stiebel, Richard Tunick, Esther Susan Lutzker, and Vivian Davis, and additional plaintiffs Ivan Pawlenko and Martin Breuninger (collectively, "Plaintiffs"), by their attorneys, allege upon personal knowledge as to their own acts and upon information and belief as to all other matters, based upon the investigation conducted by counsel, which included, inter alia, review and analysis of: (a) internal, non-public documents provided by OPKO Health, Inc. ("OPKO or "Company") in response to demands under 8 Del. C. §220; (b) the public filings of OPKO and related non-parties with the U.S. Securities and Exchange Commission ("SEC"); (c) press releases and other public statements disseminated or caused to be made or issued by defendants and related non-parties; (d) media reports concerning the Company; (e) the Complaint and related filings in the action filed by the SEC on September 7, 2018 in the United States District Court for the Southern District of New York, captioned SEC v. Honig, et al., 18-cv-8175, charging a number of entities and persons, including OPKO and its Chief Executive Officer ("CEO") and Chairman of the Board, Phillip Frost ("Frost"), with violations of the federal securities laws (the "SEC Action"); and (f) other publicly available information, as follows: NATURE AND SUMMARY OF THE ACTION 1. -
United States District Court Southern District Of
Case 1:18-cv-24137-XXXX Document 1 Entered on FLSD Docket 10/08/2018 Page 1 of 33 UNITED STATES DISTRICT COURT SOUTHERN DISTRICT OF FLORIDA CIVIL ACTION NO. 1:18cv24137 PAUL CAMHI, Individually and on Behalf of ) CLASS ACTION All Others Similarly Situated, ) ) Plaintiff, ) ) vs. ) ) OPKO HEALTH, INC. and PHILLIP FROST, ) ) Defendants. ) ) DEMAND FOR JURY TRIAL COMPLAINT FOR VIOLATIONS OF THE FEDERAL SECURITIES LAWS Case 1:18-cv-24137-XXXX Document 1 Entered on FLSD Docket 10/08/2018 Page 2 of 33 Plaintiff Paul Camhi (“plaintiff”) alleges the following based upon the investigation of plaintiff’s counsel, which included a review of U.S. Securities and Exchange Commission (“SEC”) filings by OPKO Health, Inc. (“Opko” or the “Company”), as well as regulatory filings and reports, securities analysts’ reports and advisories about the Company, press releases and other public statements issued by the Company, media reports about the Company, and the complaint in the enforcement action filed by the SEC, SEC vs. Honig, No. 18-cv-08175 (S.D.N.Y. Sept. 7, 2018) (the “SEC Complaint”) as detailed herein. Plaintiff believes that substantial additional evidentiary support will exist for the allegations set forth herein after a reasonable opportunity for discovery. NATURE OF THE ACTION 1. This is a securities class action on behalf of all purchasers of Opko common stock between October 8, 2013 and September 7, 2018, inclusive (the “Class Period”) seeking to pursue remedies under the Securities Exchange Act of 1934 (“1934 Act”). JURISDICTION AND VENUE 2. The claims asserted herein arise under and pursuant to §§10(b) and 20(a) of the 1934 Act (15 U.S.C. -
Congressional Record—Senate S1132
S1132 CONGRESSIONAL RECORD — SENATE February 13, 2006 Hospital of the University of Pennsylvania. care Corporation, Cellular Technical Serv- Office Building will now be held on He then served as a lieutenant commander in ices Co., Inc., and Ladenburg Thalmann Fi- Wednesday, February 15, 2006 at 10:30 the U.S. Public Health Service at the Na- nancial Services Inc. Dr. Frost also is co-vice a.m. in the same room. tional Cancer Institute and completed a one- chairman of the American Stock Exchange’s The purpose of the hearing is to re- year senior residency at Jackson Memorial board of governors, chairman of the board of Hospital in Miami. He joined the faculty of trustees of the University of Miami, and a ceive testimony regarding S. 2197, to the University of Miami School of Medicine trustee of Scripps Research Institute. He improve the global competitiveness of in 1966 and then moved to Mount Sinai Med- previously served as chairman of the board the United States in science and en- ical Center of Greater Miami, chairing its of directors of Key Pharmaceuticals, Inc., ergy technology, to strengthen basic Department of Dermatology from 1972 to chairman of Whitman Education Group, Inc., research programs at the Department 1990. and vice chairman of the board of directors of Energy, and to provide support for While at Mt. Sinai, Dr. Frost sold a dispos- of American Vaccine, Inc. able instrument for skin biopsies to Miles mathematics and science education at Dr. Frost and his wife, Patricia, are ardent all levels through the resources avail- Laboratory. -
Opko Health: the Placebo Effect
Opko Health: The Placebo Effect Lakewood Capital Management December 2013 /placebo effect/ (plah-se’bo ĕ-fekt’), noun [L.]: 1. the beneficial effect that occurs following a treatment administered to a group that arises simply from that group’s faith or preconceptions that the treatment will work. 2. an ineffectual treatment intended to deceive the recipient. Table of Contents A.) Executive Summary ................................................................................................... 1 B.) A Dizzying History Of Deals and Disappointment .................................................. 8 C.) Poor Financial Results… Yet A Soaring Market Capitalization ............................. 15 D.) Latin American Drug Distribution ........................................................................... 17 E.) Exploratory Alzheimer’s Diagnostic ...................................................................... 18 F.) Claros Diagnostics ................................................................................................... 19 G.) 4Kscore™ Exploratory Prostate Cancer Screening Test ......................................... 22 H.) Rayaldy .................................................................................................................... 26 I.) Prolor Biotech .......................................................................................................... 30 J.) A Web Of Stock Promotion ..................................................................................... 33 K.) Insider Share Purchases -
2019 CIBF Annual Report Interactive
ANNUAL REPORT 2019ARC CENTRE OF EXCELLENCE FOR INTEGRATIVE BRAIN FUNCTION The ARC Centre of Excellence for Integrative Brain Function acknowledges the support of the Australian Research Council 3 INTRODUCTION About 4 Strategic objectives 5 Messages 6 Highlights 8 Governance 9 RESEARCH PROGRAM Research reports 11 Publications 26 Presentations 29 CENTRE PROGRAMS Early career researchers 33 Education 36 The Brain Dialogue 38 Neuroethics 39 Neuroinformatics 40 Equity and diversity 40 Government, international and industry 41 engagement EVENTS Centre events 42 Sponsored events 44 PERSONNEL 45 KEY PERFORMANCE INDICATORS 51 FINANCE 52 ACRONYMS 54 Cover image courtesy of Tahlia H, QLD. 2016 Art competition winner. ARC CoE FOR INTEGRATIVE BRAIN FUNCTION Annual Report 2019 4 INTRODUCTION about • strategic objectives • messages • highlights • governance About Understanding how the brain interacts with the world is one of the greatest challenges of the 21st century. The ARC Centre of Excellence for Integrative Brain Function (Brain Function CoE) was established in 2014 to address this challenge by facilitating collaborations amongst Australia’s leading brain researchers in the fields of brain anatomy and physiology, neural networks, neural circuits, brain systems, human behaviour and neurotechnologies. Led by Monash University, the Centre brings together researchers from The University of Queensland, The University of New South Wales, The University of Sydney, The Australian National University, and The University of Melbourne, alongside QIMR Berghofer, and eleven international Partner Organisations across Europe, Asia and North America. By focusing on the complex brain functions that underlie three VISION To understand how the brain interacts with the world. key integrative daily-life functions of attention, prediction and decision-making, Centre researchers are undertaking fundamental Undertake fundamental investigations into the principles of brain structure and investigations into the principles of brain structure and function. -
Miller School Celebrates the Naming of the Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery
Julie Levin March 27, 2019 Miller School Celebrates the Naming of the Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery After slipping on crisp, new white lab coats, Dr. Phillip and Patricia Frost formally launched a new era for the University of Miami Leonard M. Miller School of Medicine’s prestigious Department of Dermatology. The lab coats featured a new name and logo – the Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery – a symbol of the tremendous impact the renowned South Florida philanthropist and physician has had on the department throughout its storied history. https://physician-news.umiamihealth.org/miller-school-celebrates-the-naming-of-the-dr-phillip-frost-department-of-dermatology-and-cutaneous-surgery/ 1 / 6 Julie Levin March 27, 2019 Dr. Phillip and Patricia Frost put on new lab coats with the logo of the Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery. Thanks to the Frosts’ generosity, the department will receive a $10 million endowment, which will help advance innovative treatments and cures in dermatology. The gift celebrates Dr. Frost’s lifetime of dedication to medicine, education, and medical entrepreneurship. “We hope this gift commemorates the debt that we feel to not only the department, school, and the city, but it makes us feel as though we will have a stake in its future,” said Dr. Frost, who spoke alongside his wife, Patricia, at a March 6 naming ceremony at the Miller School. https://physician-news.umiamihealth.org/miller-school-celebrates-the-naming-of-the-dr-phillip-frost-department-of-dermatology-and-cutaneous-surgery/ 2 / 6 Julie Levin March 27, 2019 One of the earliest departments founded at the Miller School, the Dr. -
World Premier International Research Center Initiative (WPI) FY 2019 WPI Project Progress Report
World Premier International Research Center Initiative (WPI) FY 2019 WPI Project Progress Report Host Institution Kyoto University Host Institution Head YAMAGIWA Juichi Res e ar ch C en t er Institute for the Advanced Study of Human Biology Center Director SAITOU Mitinori Administrative Director OGAWA Ta dashi Common instructions: * Unless otherwise specified, prepare this report based on the current (31 March 2020) situation of your WPI center. * So as to execute this fiscal year’s follow-up review on the “last” center project plan, prepare this report based on it. * Use yen (¥) when writing monetary amounts in the report. If an exchange rate is used to calculate the yen amount, give the rate. Prepare this report within 10-20 pages (excluding the appendices, and including Summary of State of WPI Center Project Progress (within 2 pages)). Summary of the State of WPI Center Project Progress (write within 2 pages) We have been making endeavors to firmly establish the Institute for the Advanced Study of Human Biology (ASHBi) as one of the WPI Centers since its launch in October 2018. Over FY2019, we held an executive board meeting every two weeks and a PI meeting every month to accelerate the establishment of the Institute. We have organized an ASHBi colloquium every month from June 2019, in addition to periodic ASHBi seminars (20 seminars in FY2019) and an ASHBi Retreat (February 2020) to strengthen interactions and create collaborations among the ASHBi PIs. A major renovation of the main building for ASHBi (Building B of the Faculty of Medicine Campus) has been completed, creating a total space of 1700 m2 for the Single-Cell Ge nome Information Analysis Core (SignAC), interaction (lounge)/seminar rooms, administrative office (ground floor), and experimental areas/offices for overseas/new PIs (1st and 2nd floors). -
Alumni History and Hall of Fame Project
Los Angeles Unified School District Alumni History and Hall of Fame Project Los Angeles Unified School District Alumni History and Hall of Fame Project Written and Edited by Bob and Sandy Collins All publication, duplication and distribution rights are donated to the Los Angeles Unified School District by the authors First Edition August 2016 Published in the United States i Alumni History and Hall of Fame Project Founding Committee and Contributors Sincere appreciation is extended to Ray Cortines, former LAUSD Superintendent of Schools, Michelle King, LAUSD Superintendent, and Nicole Elam, Chief of Staff for their ongoing support of this project. Appreciation is extended to the following members of the Founding Committee of the Alumni History and Hall of Fame Project for their expertise, insight and support. Jacob Aguilar, Roosevelt High School, Alumni Association Bob Collins, Chief Instructional Officer, Secondary, LAUSD (Retired) Sandy Collins, Principal, Columbus Middle School (Retired) Art Duardo, Principal, El Sereno Middle School (Retired) Nicole Elam, Chief of Staff Grant Francis, Venice High School (Retired) Shannon Haber, Director of Communication and Media Relations, LAUSD Bud Jacobs, Director, LAUSD High Schools and Principal, Venice High School (Retired) Michelle King, Superintendent Joyce Kleifeld, Los Angeles High School, Alumni Association, Harrison Trust Cynthia Lim, LAUSD, Director of Assessment Robin Lithgow, Theater Arts Advisor, LAUSD (Retired) Ellen Morgan, Public Information Officer Kenn Phillips, Business Community Carl J. Piper, LAUSD Legal Department Rory Pullens, Executive Director, LAUSD Arts Education Branch Belinda Stith, LAUSD Legal Department Tony White, Visual and Performing Arts Coordinator, LAUSD Beyond the Bell Branch Appreciation is also extended to the following schools, principals, assistant principals, staffs and alumni organizations for their support and contributions to this project. -
Creem As Vice Provost
VOLUME 14, NUMBER 18 MAY 23, 2008 USC taps medical center expert Mitchell Creem as Vice Provost By Jon Nalick University officials have named Mitchell R. Creem, an experienced administrator widely known for his experience in revitalizing academic medical centers, to the new position of vice provost, effective June 1. Provost C. L. Max Nikias, announced the appointment in a May 16 letter to the campus com- munity and said Creem would pro- vide crucial expertise as the University negotiates to reacquire USC University Hospital and USC Norris Cancer Hospital from Tenet Healthcare Corporation. “Vice Provost Creem will provide y h p expert leadership and guidance, a r g drawing on his vast experience… I o t o h am confident he will serve as an P k o invaluable resource for the universi- o r B ty during this transitional time,” a s i L Nikias said. © s o t Creem, who will report directly o h P to the Provost, comes to USC with NEWEST GRADS, READY FOR TAKE-OFF—Above, graduate Rian Hasson jumps for joy following the Keck a decade of success in turning School of Medicine’s commencement on May 18. around aca- demic medical HSC kicks off graduation celebration centers and with a stellar By Katie Neith Assistant Program and the School of track record of Keck School Dean Carmen A. Pharmacy were held on May 16. achievements Puliafito graduated his first class of At the Keck School ceremony, at the teaching medical students during commence- Puliafito kicked off his speech by recog- hospitals of Mitchell R. -
2009-2010 NS Student Guide
STUDENT GUIDE GRADUATE TRAINING IN NEUROSCIENCE EMORY UNIVERSITY i Revised: August 2009 TABLE OF CONTENTS Page I. Purpose and Goals of the Graduate Program ....................................................2 II. Philosophy of Graduate Training ........................................................................2 III. Admission . .............................................................................................................3 A. Criteria..............................................................................................................3 1. Undergraduate Curriculum ..........................................................................3 2. Research Experience ....................................................................................3 3. Graduate Record Examination .....................................................................3 4. Recommendations ........................................................................................3 5. Statement of Goals .......................................................................................3 6. Evaluation ....................................................................................................3 B. On Arrival ........................................................................................................4 C. International Students and Language Requirements...................................4 IV. Program Administration.......................................................................................4 V. Advising…………………………………………………………………………..4 -
YEN2021 E-Booklet
[Type here] - 2 - [Type here] About YEN The Young Embryologist Network (YEN), is an academic body aiming to bring together early career scientists within the wide field of developmental biology, in order to provide opportunities to present talks and posters, network and collaborate, and gain research or career advice. YEN was set up in 2008 by graduate students in the prestigious Department of Cell and Developmental Biology at University College London. Every year, the YEN hosts an annual conference at a UK research institution with great success. The conference is entirely organised by graduate students and junior post-doctoral scientists, and has remained free to attend since 2008, due to the generosity of sponsors and grants. The annual YEN conference is continually growing and expanding. This year, as our conference has gone virtual, we are excited to welcome over 400 attendees from all over the world! We have invited speakers and selected talks and posters to reflect the diversity of questions in the field as well as capture the range of techniques used to address them. We hope that this unique opportunity of having a global audience fosters interactions between early career researchers in the field of developmental biology, expanding the Young Embryologist Network. Acknowledgements We would like to thank all of the sponsors, speakers, talk and poster presenters, judges, Karen Lee and guests, attendees and people involved in the organisation of the YEN conference. Committee: Sergio Menchero, Maddy Demuth, Nikolaos Angelis, Michelle Neumann, Ollie Inge, Eren Akademir, Jack Morgan, Eva Kane, Luca Zanieri, Ferran Garcia Llagostera, Daniele Kunz, Jeremie Subrini, Haskan Kaya, Richard Clayton, Foteini Papaleonidopoulou & Oliver Bower. -
Annual Report Spring 2017
LEE KUM SHEUNG CENTER FOR HEALTH AND HAPPINESS Annual Report Spring 2017 CONTENTS 1 Welcome 2 Building a Science of Positive Health and Resilience 6 Advancing Rigorous and Interdisciplinary Science of Health and Happiness 12 Building Interfaculty Initiatives at Harvard University 17 Center Members and Affiliates “‘Si Li Ji Ren’ (considering others’ interests) is Lee Kum Kee’s core value, so we are very proud to support scientific advancement for the good of people around the globe. This new Center is dedicated to the science of health and happiness, which is a fitting tribute to my great-grandfather Lee Kum Sheung. Through the Center’s efforts in the field of health and happiness, we hope more people can increase their awareness, take more preventive measures, and eventually, become healthier and happier.” —Sammy Lee, Chairman & Managing Director of LKK Health Products Group On May 10 and 11, the opening of the Lee Kum Sheung Center for Health and Happiness at the Harvard T.H. Chan School of Public Health was celebrated with a ribbon-cutting ceremony, luncheon, tour of the new Center, and a reception and dinner on the Harvard University campus. Greetings from the Center Directors We are delighted to share the first annual report on the activities and accomplishments of the Lee Kum Sheung Center for Health and Happiness at the Harvard T.H. Chan School of Public Health. We are grateful to the Lee Kum Kee family for the generosity they provided to establish the Center, which will foster important insights and new discoveries regarding the relationship between physical health and emotional well-being.