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Zhen Gu, Ph.D Curriculum Vitae ZHEN GU, PH.D. Professor, Department of Bioengineering Director, NIH Biotechnology Training in Biomedical Sciences and Engineering Program University of California, Los Angeles (UCLA) 4121-J Engineering V, Los Angeles, CA 90095, USA Phone: (310) 206-3114 Fax: (310) 794-5956 Email: [email protected] Website: https://imedicationlab.net POSITIONS AND EMPLOYMENT Full Professor 2018- Department of Bioengineering Jonsson Comprehensive Cancer Center California NanoSystems Institute Center for Minimally Invasive Therapeutics University of California, Los Angeles (UCLA) Director 2019- NIH Biotechnology Training in Biomedical Sciences and Engineering Program University of California, Los Angeles (UCLA) Founding Director 2016-2018 Biomedical Engineering Translational Innovation (BME-TraIn) Practice Master of Science Program University of North Carolina at Chapel Hill | North Carolina State University Endowed Chair Associate Professor 2017-2018 Associate Professor 2016-2017 Assistant Professor 2012-2016 Joint Department of Biomedical Engineering, Pharmacoengineering Program University of North Carolina at Chapel Hill | North Carolina State University (Joint Position) Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery Eshelman School of Pharmacy (Joint Position) Department of Medicine, Division of Endocrinology and Metabolism University of North Carolina at Chapel Hill EDUCATION AND TRAINING Massachusetts Institute of Technology (MIT) | Harvard Medical School (HMS) Cambridge, MA Postdoctoral Fellow, Advisor: Robert S. Langer 2010-2012 Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, MIT Children’s Hospital Boston, HMS University of California, Los Angeles (UCLA) Los Angeles, CA Ph.D., Chemical /Biomolecular Engineering, Nanobiotechnology, Advisor: Yi Tang 2006-2010 Department of Chemical and Biomolecular Engineering | Department of Mechanical and Aerospace Engineering School of Engineering and Applied Science (2010/12/10) Nanjing University (NJU) Nanjing, China M.S., Polymer Chemistry and Physics, Advisor: Qundong Shen 2003-2006 Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering (2006/07/01) Nanjing University (NJU) Nanjing, China B.S., Chemistry, Advisors: Qundong Shen | Changzheng Yang 1999-2003 Department of Chemistry, School of Chemistry and Chemical Engineering (2003/07/01) HONORS AND AWARDS Felix Franks Medal, Royal Society of Chemistry, 2019 Highly Cited Researcher, Web of Science Group, 2019 Small Young Innovator Award, 2019 Fellow, American Institute for Medical and Biological Engineering (AIMBE), 2019 Biomaterials Science Lectureship Award, 2018 Jackson Family Distinguished Professorship of Biomedical Engineering, UNC/NC State, 2018 (relinquished) CV of Zhen Gu Young Investigator Award, Controlled Release Society (CRS), 2017 Research Achievement Award, ALCOA Foundation, 2017 Runner-up of APEC Science Prize for Innovation, Research, and Education (ASPIRE), U.S. Dept. State, 2017 Annual Health Care Hero, Triangle Business Journal, 2017 Sloan Research Fellow, Alfred P. Sloan Foundation, 2016 National Academy of Engineering (NAE) Frontiers in Engineering Invitee, 2016 GOOD 100- “100 Global Creative Individuals”, GOOD Magazine, 2016 University Faculty Scholar Award, NC State, 2016 NC TraCS 4D (Drugs, Devices and Diagnostics Development) Research Award, 2016 TR35-Global Top Innovator under 35 (Pioneer in Biomedicine and Materials), MIT Technology Review, 2015 Top 10 Science Images in Science Magazine, 2015 ACCLAIM Fellow, Program of Academic Career Leadership Academy in Medicine at UNC, 2015 Young Innovator Award of Cellular and Molecular Bioengineering (CMBE), Biomedical Engineering Society (BMES), 2015 The First Prize of Surgery-Engineering Speed Dating Award, UNC, 2015 “Young Talents in Polymer Science” Highlight, Macromolecular Chemistry and Physics, 2015 Pathway Award, American Diabetes Association, 2015 Young Faculty Research Award, Sigma Xi Chapter of the Scientific Research Society, 2014 Junior Faculty Award, American Diabetes Association, 2014 NC State Research Innovative Award, 2013, 2015 NC TraCS $50K Translational Science Pilot Award, UNC, 2013, 2015 NC State Faculty Research and Professional Development Award, 2013 Specially-Appointed Full Professor in Jiangsu Province, Nanjing University, China, 2012 (relinquished) Excellent Publication Award of Key Laboratory of Mesoscopic Chemistry, China, 2011 Chinese Government Award for Outstanding Ph.D. Students Abroad, Los Angeles, 2010 Fellowship of “Functional Engineered Nano Architectonics” (FENA), UCLA, 2008 Distinguished Graduate Student, NJU, 2006 Finalist for DSM Business Course-“2006-ZHUO”, Shanghai, 2006 Scholarship of National Distinguished Graduate Student, China, 2005 Dai An-Bang Scholarship for Excellent Experimental Abilities, China, 2003 Distinguished Youth Leadership Award in Jiangsu Province, China, 2003 Distinguished Model Student of NJU, 2002 GuangHua Scholarship for Outstanding Undergraduate Students, China, 2002 The First Prize of People’s Scholarship for Distinguished Students in NJU, 2002 The First Prize of People’s Scholarship for Distinguished Students in NJU, 2001 The First Prize of 6th Academic Paper Competition in NJU, 2001 The First Prize of 10th Youth Creativity Competition in Jiangsu Province, China, 1999 PUBLICATIONS JOURNAL PAPERS (*: corresponding author; †: equal contribution) 1. Jicheng Yu, Jinqiang Wang, Yuqi Zhang, Guojun Chen, Weiwei Mao, Yanqi Ye, Anna R. Kahkoska, John B. Buse, Robert Langer and Zhen Gu*, “Glucose-responsive smart insulin patch for blood glucose regulation in mice and pigs”, Nature Biomedical Engineering, in press, 2020. 2. Qian Chen, Chao Wang, Xudong Zhang, Guojun Chen, Quanyin Hu, Hongjun Li, Jinqiang Wang, Di Wen, Yuqi Zhang, Guang Yang, Yifei Lu, Chen Jiang, Gianpietro Dotti, Jun Wang, Zhen Gu*, “In situ Sprayed Bioresponsive Immunotherapeutic Gel for Post-Surgical Cancer Treatment”, Nature Nanotechnology, 14(89), 2019. (Cover Feature) 3. Jinqiang Wang, Jicheng Yu, Yuqi Zhang, Anna R.Kahkoska, Zejun Wang, Jun Fang, Julian P. Whitelegge, Song Li, John B. Buse, and Zhen Gu*, “Glucose Transporter Inhibitor-Modified Insulin Mitigates Hypoglycemia”, Proceedings of the National Academy of Sciences U.S.A. (PNAS), 22(10744), 2019. 4. Quan Zhou+, Shiqun Shao+, Jinqiang Wang, Changhuo Xu, Jiajia Xiang, Ying Piao, Zhuxian Zhou, Qingsong Yu, Jianbin Tang, Xiangrui Liu, Zhihua Gan, Ran Mo, Zhen Gu*, and Youqing Shen*, “Enzyme-Activatable Polymer-Drug Conjugate Augments Tumour Penetration and Treatment Efficacy”, Nature Nanotechnology, 14(799), 2019. - 2 - CV of Zhen Gu 5. Jinqiang Wang+, Jicheng Yu+, Yuqi Zhang, Xudong Zhang, Anna R. Kahkoska, Guojun Chen, Zejun Wang, Wujin Sun, Lulu Cai, Zhaowei Chen, Chenggen Qian, Qundong Shen, Ali Khademhosseini, John B. Buse, and Zhen Gu*, “Charge-Switchable Polymeric Complex for Glucose-Responsive Insulin Delivery in Mice and Pigs”, Science Advances, 5(eaaw4357), 2019. 6. Di Wen, Jinqiang Wang, George Van Den Driessche, Qian Chen, Yuqi Zhang, Guojun Chen, Hongjun Li, Jennifer Soto, Ming Liu, Masao Ohashi, Zejun Wang, Peter Abdou, Quanyin Hu, Gianpietro Dotti, Song Li, Denis Fourches, and Zhen Gu*, “Leverage Lipid Metabolism for Anticancer Drug Delivery”, Matter, in press, 2019. 7. Guojun Chen, Zhen Gu*, “A prophylactic and a therapeutic against AML”, Nature Biomedical Engineering, in press, 2020. (News & Views) 8. Jian Jiang, Na Shen, Tianyuan Ci, Zhaohui Tang*, Zhen Gu*, Gao Li, and Xuesi Chen*, “Combretastatin A4 nanodrug-induced MMP9-amplification boosts tumor-selective release doxorubicin prodrug”, Advanced Materials, in press, 2019. 9. Xiao Han, Shufang Shen, Qin Fan, Guojun Chen, Edikan Archibong, Gianpietro Dotti, Zhuang Liu*, Zhen Gu*, and Chao Wang*, “Red Blood Cell-Derived Nanoerythrosome for Antigen Delivery with Enhanced Cancer Immunotherapy”, Science Advances, in press, 2019. 10. Jinqiang Wang, Zejun Wang, Jicheng Yu, Yuqi Zhang, Anna R. Kahkoska, John B. Buse, and Zhen Gu*, “A Forskolin-Conjugated Insulin Analog Targeting Endogenous Glucose-Transporter for Glucose-Responsive Insulin Delivery”, Biomaterials Science, in press, 2019. 11. Da Huo, Jianfeng Zhu, Guojun Chen, Qian Chen, Chao Zhang, Xingyu Luo, Wei Jiang, Xiqun Jiang*, Zhen Gu*, Yong Hu*, “Eradication of Unresectable Liver Metastasis Through Induction of Tumour Specific Energy Depletion”, Nature Communications, 10(3051), 2019. 12. Tingxizi Liang, Zhaowei Chen, Zejun Wang, Jun-Jie Zhu and Zhen Gu*, “Nanotechnology against Diabetes”, Journal of Physics D: Applied Physics, in press, 2020. 13. KangJu Lee, Marcus J. Goudie, Peyton Tebon, Wujin Sun, Zhimin Luo, Junmin Lee, Shiming Zhang, Kirsten Fetah, Han-Jun Kim, Yumeng Xue, Mohammad Ali Darabi, Samad Ahadian, Einollah Sarikhani, WonHyoung Ryu, Zhen Gu, Paul S. Weiss, Mehmet R. Dokmeci, Nureddin Ashammakhi*, Ali Khademhosseini*, “Non-transdermal Microneedles for Advanced Drug Delivery”, Advanced Drug Delivery Reviews, in press, 2020. 14. Cong-Fei Xu+,Guo-Jun Chen+,Ying-Li Luo,Yue Zhang, Gui Zhao, Zi-Dong Lu, Anna Czarnah, Zhen Gu*, Jun Wang*, “Rational designs of in vivo CRISPR-Cas delivery systems”, Advanced Drug Delivery Reviews, in press, 2020. 15. Yi Zeng, Jinqiang Wang*, Zhongze Gu, and Zhen Gu*, “Engineering Glucose-Responsive Insulin”, Medicine in Drug Discovery, in press, 2020. 16. Shuangjiang Yu*, Zhaowei Chen, Xuan Zeng, Xuesi Chen*, and Zhen Gu*, “Advances in nanomedicine for cancer
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