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Cedars-Sinai Neurosciences 2020 Annual Report

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Cedars-Sinai Neurosciences 2020 Annual Report CEDARS-SINAI NEUROSCIENCES 2020 ANNUAL REPORT 200513_Neuro_Report_rev2_pro Split.indd 1 5/13/20 5:34 PM 200513_Neuro_Report_rev2_pro Split.indd 2 5/13/20 5:34 PM 1 Dear Colleague, We are delighted to share our annual report with you. As our colleague and supporter, you play an essential role in our current success and ongoing eorts to combat neurological disease and disability. It’s been an extraordinary year. Our departments have made great strides in research and patient care as well as in training the next generation of neurologists and neurosurgeons. Every day, we see our clinicians, researchers and sta embody Cedars-Sinai’s tradition of excellence and compassion. From personalized care to life-changing inventions and discoveries, they make a di erence in the lives of thousands of patients who come to us from throughout the region, the nation and the world. Our commitment and achievements are reected in the many accolades and awards our departments have recently garnered. You can read about them in this report. You will also learn about the breakthroughs we are making in every subspecialty of neurology and neurosurgery. We are honored to present these highlights. Keith Black, MD Nancy Sicotte, MD, FAAN Chair, Department of Chair, Department of Neurosurgery Neurology Ruth and Lawrence Harvey Women’s Guild Chair in Neuroscience Distinguished Chair in Neurology 2020 Annual Report 200513_Neuro_Report_rev2_pro Split.indd 3 5/13/20 5:34 PM 2 2019 HIGHLIGHTS Neurosciences at a Glance Ranking Full-Time Faculty in the nation in Neurology and Neurosurgery No. 12 in U.S. News & World Report 20 Neurosurgery Patient Visits 21 40,000+ Neurosurgery and Neurology Neurology Cedars-Sinai expanded our telestroke program to In June, a gift from the family of the late real help community hospitals provide advanced stroke estate developer Jona Goldrich founded the Jona care at the bedside within minutes. Emergency Goldrich Center for Alzheimer’s and Memory department physicians can access an on-call team Disorders, where physician-scientists will work on of stroke experts hours a day via videoconferencing developing new patient-care therapies that address to consult on urgent cases. This collaboration allows the challenges of the rapidly growing population of eligible stroke patients to receive recanalization patients with Alzheimer’s disease and other treatment as soon as possible at their local hospital. memory disorders. Videoconferencing enables our experts to remotely view and examine patients in real time, ask questions, In September, Cedars-Sinai was named the interpret imaging results and coordinate care coordinating center for a National Institutes of with local hospital teams. For complex stroke Health-funded, multicenter study that will assess cases, the Cedars-Sinai Transfer Center can help the effectiveness of six potential stroke therapies. coordinate higher-level-of-care evaluations in our The study will also examine whether applying closed-method neuro intensive care unit. higher standards of rigor to early phases of research might produce results that are more likely The Ray Charles Foundation provided a generous to succeed in human clinical trials. gift to establish the Ray Charles Foundation Scholars Fund in Neurosurgery, a scholarship that The Women’s Guild Neurology Project launched oers recipients opportunities for research, in 2019 to support innovative research and mentorship and career guidance under the education for the understanding and treatment leadership of Cedars-Sinai’s neurosciences faculty. of complex neurological disorders. This comprehensive project supports the Women’s Julia Ljubimova, MD, PhD, published a mouse study Guild Distinguished Chair in Neurology, held by in the journal Nature Communications showing the Nancy Sicotte, MD, chair of the Department of use of immunothera py to ­ght some of the most Neurology, as well as a fund for programmatic deadly brain tumors using innovative nanomedicine expansion and enrichment of the department’s to pass through the blood-brain barrier. clinical and research activities. Cedars-Sinai Neurosciences 200513_Neuro_Report_rev2_pro Split.indd 4 5/13/20 5:34 PM 3 LATE-BREAKING RESEARCH Parkinson’s Investigators at Cedars-Sinai precancers of the skin—reduced the Disease engineered induced pluripotent stem elevated levels of alpha-synuclein in cells (iPSCs) from cells of patients both the dopamine neurons in the with young-onset Parkinson’s disease dish and in laboratory mice. The drug to produce dopamine neurons and also countered another abnormality analyze their functions. The team they found in the patients’ dopamine detected two key abnormalities: an neurons: elevated levels of an active accumulation of a protein called version of protein kinase C—although alpha-synuclein, which occurs in the role of this enzyme version in most forms of Parkinson’s disease, Parkinson’s is not clear. and malfunctioning lysosomes—cell The research, published in structures that allow the cell to break Nature Medicine, is being led by down and dispose of proteins. This Clive Svendsen, PhD, director of the malfunction could cause a buildup of Cedars-Sinai Board of Governors alpha-synuclein. Regenerative Medicine Institute and The team also used the iPSC the Kerry and Simone Vickar Family model to test a number of drugs that Foundation Distinguished Chair in might reverse the abnormalities they Regenerative Medicine, and Michele had observed. They found that one Tagliati, MD, vice chair of Neurology of the drugs, PEP—which is at Cedars-Sinai and the Caron and already approved by the Food and Steven D. Broidy Chair in Movement Drug Administration for treating Disorders. Memory The neuronal mechanisms that allow temporal lobe employs a “phase Disorders us to actively remember multiple code” to achieve this. The study, to items are referred to as working be published in Neuron, revealed that memory. A critical question for such neurons become active at particular memory is how we tell the dierent parts of an ongoing brain oscillation. items apart that we are holding in This work provides critical new our mind—e.g., which number insights into the mechanisms of was rst and which was second? working memory and continues an A research team under the earlier discovery of persistently leadership of Ueli Rutishauser, PhD, active cells, published in Nature the Board of Governors Chair in Neuroscience in . The new team Neurosciences and director of studied the same type of cells, but in Human Neurophysiology Research, the context of how dierent items discovered that a specic class of are simultaneously held in memory. neurons in the human medial 2020 Annual Report 200513_Neuro_Report_rev2_pro Split.indd 5 5/13/20 5:34 PM At age , Albert Parisi was coaching his son’s T-ball game when pain cracked through the back of his head. Eventually, an MRI revealed a brain tumor. Today, Parisi has been cancer-free for years. He found inspiration in his illness, writing books and serving as a counselor and volunteer to support cancer su­erers. Parisi credits his longevity to three factors: his faith, his attitude and the skill of his surgeon, Keith Black, MD. Cedars-Sinai Neurosciences 200513_Neuro_Report_rev2_pro Split.indd 6 5/13/20 5:34 PM 5 BRAIN TUMOR Keith L. Black, MD The Brain Tumor Center at Cedars-Sinai is Ruth and Lawrence Harvey Chair in Neuroscience internationally recognized for innovative Chair, Department of Neurosurgery treatments, including discoveries that enable Director, Maxine Dunitz Neurosurgical Institute anticancer drugs to be delivered directly into the brain. Our physicians are at the helm of new research being tested in clinical trials and adopted into new treatment options that directly benet patients. When possible, we employ the latest in minimally invasive neurosurgery techniques and technology, including radiosurgery and NICO BrainPath. Cedars-Sinai was the rst medical facility on the West Coast to o er the Radionics ConforMAX Mini-Multileaf Collimator and the rst center in California to use Synaptive Medical’s BrightMatter Guide exoscope system. 38 The Cedars-Sinai Brain Investigators at Cedars-Sinai, led by neurosurgeon Adam Tumor Center has 38 Mamelak, MD, completed a Phase I trial in 2019 of a unique open clinical trials and substance derived from scorpion venom, which, used in three additional trials in combination with a special high-sensitivity, near-infrared development. camera developed at Cedars-Sinai, allows neurosurgeons to better detect boundaries between brain tumor tissue and healthy brain. Technologies like this have the potential to help surgeons better remove some of the most deadly types of brain tumors. 2020 Annual Report 200513_Neuro_Report_rev2_pro Split.indd 7 5/13/20 5:35 PM Lisa Simmons was suering from horric headaches and began to have hearing loss. Specialists misdiagnosed her or said there was nothing they could do. She nally found Wouter I. Schievink, MD, and traveled from Seattle to see him. Schievink treated the problem with blood patches. It worked. Simmons felt instant relief from the crushing pain. Her hearing came back as well. “It was the most amazing moment of my life,” she recalls. “I wish I lived closer so all my medical needs could be taken care of at Cedars-Sinai.” Cedars-Sinai Neurosciences 200513_Neuro_Report_rev2_pro Split.indd 8 5/13/20 5:35 PM 7 CSF LEAK Wouter I. Schievink, MD A cerebrospinal uid (CSF) leak is di cult to Director, Microvascular Neurosurgery Program diagnose, and highly specialized care is paramount for patients whose condition does not resolve on its own. The dedicated CSF Leak Program at Cedars-Sinai focuses on advanced diagnostics and intervention to stop the debilitating pain and impediments associated with the illness. Our specialized team uses advanced imaging techniques to provide the best information for treatment planning, including cisternography and digital subtraction myelography to identify the location of a suspected CSF leak. 2,000 In the year 2000, Cedars- Wouter I. Schievink, MD, is one of the world’s most renowned Sinai was the first hospital pioneers in intracranial hypotension and CSF leak.
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