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Supplementary material Gut gene p_val avg_diff pct.1 pct.2 cluster ANG 1.77E-23 1.611213989 0.675 0.173 1 NUCB2 8.23E-23 1.560241508 0.754 0.295 1 PPIC 3.53E-19 1.500679845 0.659 0.206 1 AZGP1 2.56E-18 1.803118296 0.516 0.117 1 ANPEP 3.36E-16 1.817540521 0.492 0.114 1 PCSK1 4.92E-16 1.704990672 0.627 0.228 1 FGL1 7.88E-15 3.965378645 0.294 0.033 1 MEP1A 2.20E-14 2.240233344 0.27 0.019 1 PTGER2 2.23E-12 1.637079832 0.349 0.062 1 SLC36A4 2.39E-12 1.666622267 0.357 0.073 1 C2orf69 5.48E-11 1.675791555 0.278 0.043 1 SPATA6 1.49E-10 1.531305362 0.294 0.051 1 NFYB 1.22E-09 1.89849823 0.31 0.07 1 ATP5S 5.30E-08 1.618240776 0.317 0.087 1 TM4SF4 1.22E-07 1.793282346 0.294 0.079 1 TPSB2 1.14E-51 2.91708951 0.851 0.147 2 TPSAB1 3.04E-49 3.954178442 0.737 0.063 2 MZB1 8.85E-49 2.306552887 0.895 0.286 2 JCHAIN 6.44E-47 2.256474522 0.982 0.753 2 IGLL5 6.33E-44 2.330834591 0.939 0.601 2 LCN2 1.77E-32 1.608471747 1 0.808 2 CPA3 3.10E-30 2.745159486 0.596 0.073 2 DERL3 8.10E-30 1.829185005 0.781 0.215 2 DUOX2 3.41E-29 1.945055996 0.868 0.325 2 CD79A 3.94E-29 2.139221979 0.588 0.071 2 PIM2 6.98E-21 2.000868651 0.649 0.189 2 DMBT1 1.03E-19 2.050194033 0.605 0.184 2 OLFM4 8.58E-19 3.143234512 0.386 0.042 2 CCL20 1.33E-16 1.621672697 0.623 0.202 2 RAB30 4.95E-15 1.647933066 0.447 0.087 2 SPINK1 2.22E-14 1.635407096 0.719 0.375 2 DUOXA2 3.35E-14 2.110597776 0.404 0.073 2 RGS2 5.83E-14 1.668949661 0.719 0.346 2 CD27 5.84E-14 1.848354621 0.325 0.045 2 LINC01480 2.49E-13 3.101291987 0.316 0.047 2 ALOX5AP 3.30E-13 1.979043157 0.307 0.05 2 PI3 5.00E-13 2.2328048 0.465 0.118 2 TNFRSF17 1.80E-12 2.313834825 0.298 0.039 2 CLCA1 2.51E-12 4.482967837 0.263 0.029 2 FABP1 1.81E-11 2.298824713 0.368 0.079 2 RHOH 3.97E-11 1.8455681 0.307 0.047 2 CD69 9.06E-11 1.51129071 0.386 0.113 2 TAGAP 1.30E-10 1.721643948 0.289 0.047 2 BCL2A1 5.10E-10 2.122266555 0.316 0.066 2 C10orf99 1.38E-09 2.00432171 0.333 0.136 2 SAMSN1 2.86E-09 1.863623777 0.298 0.06 2 SLAMF7 1.09E-08 1.840022323 0.272 0.06 2 Li J, et al. Gut 2019;0:1–11. doi: 10.1136/gutjnl-2019-319438 Supplementary material Gut RAC2 7.90E-08 1.608233727 0.325 0.092 2 ZNF331 2.47E-07 1.736368262 0.36 0.134 2 CD38 3.06E-07 1.507380516 0.316 0.097 2 HOXB5 4.62E-07 1.887206952 0.333 0.181 2 LAMB1 3.60E-05 1.527380126 0.377 0.181 2 CTSH 6.85E-05 1.525732644 0.325 0.139 2 UTRN 0.000242318 1.545212508 0.307 0.163 2 IDO1 0.002483373 1.570956611 0.342 0.257 2 KRT17 2.67E-62 5.94414692 0.9 0.032 3 MUC6 1.72E-58 6.21625596 0.883 0.009 3 KRT6B 1.01E-52 4.230164229 0.9 0.051 3 PTPRO 2.25E-45 3.871330733 0.817 0.028 3 BMP4 4.73E-41 3.25285692 0.85 0.085 3 CEACAM6 4.84E-37 2.23425674 0.95 0.483 3 CD24 1.52E-36 2.217321953 0.933 0.492 3 DPEP1 1.18E-35 2.812514814 0.883 0.17 3 NOTUM 1.06E-30 4.306955368 0.517 0.002 3 LRP4 6.21E-30 3.730260891 0.65 0.034 3 ASCL2 8.75E-30 2.858591972 0.7 0.048 3 PRAP1 1.64E-28 2.53409503 0.7 0.067 3 BAMBI 8.66E-28 2.821631774 0.667 0.069 3 SPON2 4.06E-26 2.770768528 0.7 0.161 3 INHBB 2.24E-25 5.080786724 0.467 0.005 3 PADI1 2.36E-24 4.309458724 0.467 0.007 3 SYT8 9.51E-24 3.10492803 0.583 0.037 3 FIBCD1 2.61E-23 3.181118494 0.5 0.016 3 PLEKHA4 2.15E-22 2.499109562 0.633 0.062 3 BST2 8.83E-22 2.789499318 0.617 0.147 3 S100A4 9.39E-22 2.319435211 0.883 0.37 3 NKD1 1.34E-21 3.081472784 0.517 0.034 3 CTNNB1 5.07E-21 1.903124499 0.817 0.395 3 WNT11 1.06E-20 5.635330596 0.35 0 3 PTMS 2.79E-20 1.848512623 0.9 0.4 3 SPRR1A 5.84E-20 4.376255143 0.383 0.005 3 SFRP5 1.24E-19 5.693120832 0.333 0 3 LCK 1.59E-19 3.35733509 0.5 0.044 3 VSNL1 3.33E-19 1.803232141 0.75 0.241 3 EPSTI1 4.38E-19 2.18422394 0.7 0.136 3 SCD 6.36E-19 2.100364985 0.8 0.267 3 CCND2 6.52E-19 2.096020275 0.7 0.14 3 APOLD1 1.27E-18 2.700849276 0.567 0.074 3 SESN1 1.94E-18 1.746431963 0.8 0.223 3 CXCL8 2.31E-18 1.997309805 0.933 0.593 3 LGR6 2.36E-18 2.422710396 0.517 0.044 3 ANXA6 5.03E-18 3.246462598 0.467 0.039 3 PSTPIP2 6.92E-18 3.047429509 0.433 0.025 3 EDAR 7.49E-18 3.860430995 0.4 0.014 3 HOXB-AS3 1.06E-17 2.014425727 0.633 0.103 3 Li J, et al. Gut 2019;0:1–11. doi: 10.1136/gutjnl-2019-319438 Supplementary material Gut MYBPC1 1.61E-17 4.724876456 0.333 0.005 3 SNAR-E 2.17E-16 4.41068356 0.35 0.009 3 RNF128 2.21E-16 1.909973815 0.55 0.092 3 RFK 2.34E-16 1.833142239 0.7 0.17 3 HOXB9 3.56E-16 3.149995617 0.467 0.048 3 TNFAIP2 6.45E-16 2.610333756 0.6 0.133 3 LOC102723854 9.10E-16 4.644340197 0.367 0.021 3 SLC2A1 1.73E-15 1.945476504 0.717 0.274 3 GGH 3.39E-15 1.861401417 0.683 0.232 3 TNNI2 3.61E-15 2.001226409 0.317 0.011 3 KRT23 5.36E-15 5.978792487 0.267 0.002 3 MORC4 6.26E-15 1.541564769 0.517 0.074 3 GALNT9 7.06E-15 4.658099817 0.3 0.005 3 RUNX3 2.27E-14 2.650796708 0.5 0.08 3 ABHD12B 3.18E-14 4.426090702 0.283 0.007 3 RUNX1 5.07E-14 1.60973605 0.617 0.129 3 ZDHHC9 6.94E-14 1.712275499 0.683 0.276 3 LINC00458 1.06E-13 1.728180868 0.6 0.149 3 EMP1 1.14E-13 2.604456192 0.483 0.08 3 MLXIPL 1.68E-13 1.824643753 0.517 0.083 3 XAF1 1.82E-13 1.556999694 0.683 0.244 3 ETV1 3.84E-13 1.660259834 0.4 0.041 3 KLK6 4.78E-13 2.778971034 0.35 0.023 3 KLK7 5.40E-13 3.305525576 0.3 0.011 3 DCAF7 6.37E-13 1.585919725 0.783 0.393 3 UBE2E2 6.87E-13 1.990726171 0.283 0.011 3 CYP4X1 8.68E-13 1.997741584 0.333 0.021 3 CNN3 8.78E-13 1.538125184 0.65 0.191 3 HMGB3 1.11E-12 1.589614852 0.667 0.191 3 NOTCH1 1.14E-12 1.689697458 0.7 0.234 3 SLCO1B3 1.22E-12 1.628335619 0.483 0.076 3 HMGA1 1.53E-12 1.561366207 0.8 0.595 3 PROX1 1.73E-12 1.874468876 0.583 0.184 3 CLDN1 1.99E-12 1.925143794 0.55 0.122 3 PLA2G2A 3.27E-12 1.855142107 0.65 0.253 3 SUPT4H1 4.43E-12 1.586325999 0.667 0.202 3 MGAT5 5.65E-12 1.811142144 0.583 0.189 3 ZAK 8.42E-12 1.698770922 0.7 0.237 3 ADAMTS14 9.06E-12 3.856186893 0.283 0.011 3 ITPR2 9.38E-12 1.561184131 0.733 0.278 3 CAB39L 1.32E-11 3.417429354 0.3 0.028 3 NMU 1.35E-11 2.56638039 0.383 0.044 3 FGFR1 1.39E-11 3.290239483 0.333 0.03 3 KRT80 1.74E-11 2.030463926 0.467 0.078 3 RGL1 3.40E-11 3.790759138 0.283 0.018 3 FLNA 5.81E-11 1.82024454 0.517 0.129 3 TRIM29 7.11E-11 1.619613644 0.6 0.2 3 FAM58A 8.90E-11 2.124759102 0.483 0.092 3 Li J, et al.