Supplementary Table S1. Primers Pairs Used in Qpcr

Supplementary Table S1. Primers pairs used in qPCR

Gene Primer Sequence 5'-3' IL32 Forward AATCAGGACGTGGACAGGTGATGT Reverse TGCTCCTCATAATAAGCCGCCACT IL8 Forward AGAAACCACCGGAAGGAACCATCT Reverse AGAGCTGCAGAAATCAGGAAGGCT IL17C Forward CTTCCAGCCCTTAAAGCTGCAGAA Reverse GTACTTCCAAGGAGGTTGGGAAGA IL10RA Forward ACCAGATGTGCTGAAGAGAAGGCA Reverse TCATCAACCAGGCATCTCCCGAAT CCL2 Forward CAGCAAGTGTCCCAAAGAAGCTGT Reverse TGGAATCCTGAACCCACTTCTGCT BMP7 Forward TGAACTCCTACATGAACGCCACCA Reverse TGACGTTGGAGCTGTCATCGAAGT AKT3 Forward TCTGAGGACCGCACACGTTTCTAT Reverse TGGCTGCATCTGTGATCCCTTCTT LCN2 Forward GTGAGCACCAACTACAACCAGCAT Reverse TTCCGAAGTCAGCTCCTTGGTTCT NOS3 Forward ACACAAGACTCCAGGGAAGCACAT Reverse CACGCTCTTCAAGTTGCCCATGTT PAGE4 Forward TCTCAGCAAGAGGAACCACCAACT Reverse TTACATCAGAGCCATCTCCACGCT CXCR2 ForwardForward AGAAGTTTCGCCATGGACTCCTCA Reverse AGTGGAAGTGTGCCCTGAAGAAGA CXCR7 Forward TTCGTCATCGGCATGATTGCCAAC Reverse ATGTAGCAGTGCGTGTCATAGCCT IRS1 Forward TTCTAGTGGTGCCTGAGCTGGTTT Reverse AAACCCTTCGTGTCGCCAGAGTAT NQO1 Forward AAGGATGGAAGAAACGCCTGGAGA Reverse GGCCCACAGAAAGGCCAAATTTCT NPM2 Forward TCTCCATGGTAGGAGTGCAGCTTT Reverse ATAACGTTCCTGGCCACTGAGGAA DBC1 Forward TCTGTGAGTTCCGTCCTTCTGCAA Reverse AGGCCGACTGGACAAACTTCTCTT IGFBP3 Forward CCAAACCCAAGAAGGTCTGGCAAA Reverse TTCAAGGAGAGCTCTATGCAGCGT AR Forward AGGAGGAAGGAGAGGCTTCC Reverse GAGCAAGGCTGCAAAGGAGT PSA Forward AATCGATTCCTCAGGCCAGGTGAT Reverse AGAACTCCTCTGGTTCAATGCTGC Supplementary Table S2: List of upregulated genes in NQO1 knockdown LNCaP cells

adj. p- Fold SeqName Earray_Refseq p-value value change Description CCL2 NM_002982 2.63E-03 1.27E-01 11.651 Homo sapiens chemokine (C-C motif) ligand 2 (CCL2) COL12A1 NM_004370 2.88E-03 1.30E-01 10.921 Homo sapiens collagen, type XII, alpha 1 (COL12A1), transcript variant long OR51E1 NM_152430 1.21E-02 1.57E-01 10.820 Homo sapiens olfactory receptor, family 51, subfamily E, member 1 (OR51E1) OR51E1 NM_152430 9.72E-03 1.50E-01 8.646 Homo sapiens olfactory receptor, family 51, subfamily E, member 1 (OR51E1) C8orf47 NM_173549 3.63E-03 1.32E-01 8.076 Homo sapiens chromosome 8 open reading frame 47 (C8orf47), transcript variant 1 DIO3 NM_001362 2.86E-02 1.99E-01 6.118 Homo sapiens deiodinase, iodothyronine, type III (DIO3) KCNU1 NM_001031836 1.30E-02 1.60E-01 6.063 Homo sapiens potassium channel, subfamily U, member 1 (KCNU1) DIO3 NM_001362 1.42E-02 1.64E-01 5.843 Homo sapiens deiodinase, iodothyronine, type III (DIO3) KLK8 NM_144505 3.15E-03 1.31E-01 5.707 Homo sapiens kallikrein-related peptidase 8 (KLK8), transcript variant 2 anion_exchanger NM_000342 2.65E-04 9.90E-02 5.501 Homo sapiens solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) (SLC4A1) UBD NM_006398 2.00E-02 1.79E-01 5.148 Homo sapiens ubiquitin D (UBD) FIGNL2 NM_001013690 2.31E-02 1.85E-01 4.788 Homo sapiens fidgetin-like 2 (FIGNL2) IL8 NM_000584 9.57E-03 1.49E-01 4.440 Homo sapiens interleukin 8 (IL8) KCNJ12 NM_021012 2.02E-02 1.79E-01 4.429 Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 12 (KCNJ12) TSHZ3 NM_020856 3.93E-02 2.23E-01 4.300 Homo sapiens teashirt zinc finger homeobox 3 (TSHZ3) KCNJ3 NM_002239 3.94E-04 1.02E-01 4.235 Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 3 (KCNJ3) SPATS1 NM_145026 1.04E-03 1.17E-01 4.149 Homo sapiens spermatogenesis associated, serine-rich 1 (SPATS1) LCN2 NM_005564 1.03E-02 1.51E-01 4.091 Homo sapiens lipocalin 2 (LCN2) P2RX6 NM_005446 7.04E-03 1.42E-01 3.996 Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 6 (P2RX6), transcript variant 1 SGCE NM_001099401 4.28E-03 1.33E-01 3.964 Homo sapiens sarcoglycan, epsilon (SGCE), transcript variant 1 CCL20 NM_004591 7.37E-04 1.13E-01 3.952 Homo sapiens chemokine (C-C motif) ligand 20 (CCL20), transcript variant 1 STMN4 NM_030795 1.74E-02 1.73E-01 3.891 Homo sapiens stathmin-like 4 (STMN4) COL13A1 NM_080801 2.74E-02 1.97E-01 3.747 Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 5 SH2D3C NM_170600 3.35E-02 2.10E-01 3.687 Homo sapiens SH2 domain containing 3C (SH2D3C), transcript variant 1 DPY19L1 NM_015283 4.84E-03 1.35E-01 3.654 Homo sapiens dpy-19-like 1 (C. elegans) (DPY19L1) PAGE4 NM_007003 3.08E-02 2.04E-01 3.564 Homo sapiens P antigen family, member 4 (prostate associated) (PAGE4) CAMKV NM_024046 4.08E-02 2.26E-01 3.550 Homo sapiens CaM kinase-like vesicle-associated (CAMKV) OR1N1 NM_012363 7.29E-03 1.43E-01 3.494 Homo sapiens olfactory receptor, family 1, subfamily N, member 1 (OR1N1) AKT3 NM_181690 2.51E-02 1.91E-01 3.465 Homo sapiens v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) (AKT3), transcript variant 2 CD70 NM_001252 1.86E-02 1.75E-01 3.398 Homo sapiens CD70 molecule (CD70) ANGPT2 NM_ 001147 4.76E4.76E-03-03 1.35E1.35E-01-01 3.3453.345 Homo sapiens angiopoietin 2 (ANGPT2),(ANGPT2), transcript variant 1 C2orf61 NM_173649 3.76E-02 2.20E-01 3.343 Homo sapiens chromosome 2 open reading frame 61 (C2orf61), transcript variant 2

SLC1A3 NM_004172 2.63E-03 1.27E-01 3.333 Homo sapiens solute carrier family 1 (glial high affinity glutamate transporter), member 3 (SLC1A3), transcript variant 1 KIAA2022 NM_001008537 1.90E-02 1.76E-01 3.310 Homo sapiens KIAA2022 (KIAA2022) FAM65B NM_014722 2.17E-03 1.23E-01 3.268 Homo sapiens family with sequence similarity 65, member B (FAM65B), transcript variant 1 C11orf41 NM_012194 2.04E-02 1.80E-01 3.251 Homo sapiens chromosome 11 open reading frame 41 (C11orf41) CXCL2 NM_002089 4.80E-02 2.42E-01 3.230 Homo sapiens chemokine (C-X-C motif) ligand 2 (CXCL2) PDE4DIP NM_022359 4.61E-03 1.34E-01 3.220 Homo sapiens phosphodiesterase 4D interacting protein (PDE4DIP), transcript variant 3 LCN8 NM_178469 6.70E-03 1.41E-01 3.204 Homo sapiens lipocalin 8 (LCN8) CES1 NM_001025195 1.51E-02 1.67E-01 3.160 Homo sapiens carboxylesterase 1 (CES1), transcript variant 1 LOC728137 NM_001077697 3.80E-03 1.33E-01 3.120 Homo sapiens testis specific protein, Y-linked 3 (TSPY3) MAF NM_001031804 4.91E-04 1.09E-01 3.106 Homo sapiens v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) (MAF), transcript variant 2 NPPC NM_024409 1.22E-04 8.70E-02 3.081 Homo sapiens natriuretic peptide C (NPPC) PDE4D NM_001165899 1.94E-02 1.77E-01 3.075 Homo sapiens phosphodiesterase 4D, cAMP-specific (PDE4D), transcript variant 3 TSPY3 NM_022573 2.29E-02 1.85E-01 3.053 Homo sapiens testis specific protein, Y-linked 2 (TSPY2) IKZF1 NM_006060 2.05E-02 1.80E-01 3.031 Homo sapiens IKAROS family zinc finger 1 (Ikaros) (IKZF1), transcript variant 1 IRS1 NM_005544 8.81E-03 1.47E-01 3.004 Homo sapiens insulin receptor substrate 1 (IRS1) PRKCB NM_002738 2.81E-02 1.98E-01 2.976 Homo sapiens protein kinase C, beta (PRKCB), transcript variant 2 PDGFC NM_016205 3.35E-02 2.10E-01 2.952 Homo sapiens platelet derived growth factor C (PDGFC), transcript variant 1 NAV3 NM_014903 2.90E-02 2.00E-01 2.946 Homo sapiens neuron navigator 3 (NAV3) CAMK1D NM_020397 3.43E-03 1.32E-01 2.944 Homo sapiens calcium/calmodulin-dependent protein kinase ID (CAMK1D), transcript variant 1 PPP4R4 NM_058237 4.09E-02 2.26E-01 2.894 Homo sapiens protein phosphatase 4, regulatory subunit 4 (PPP4R4), transcript variant 1 IER3 NM_003897 2.54E-02 1.92E-01 2.882 Homo sapiens immediate early response 3 (IER3) CHODL NM_024944 2.11E-02 1.81E-01 2.818 Homo sapiens chondrolectin (CHODL), transcript variant 1 ADRA2C NM_000683 1.27E-02 1.59E-01 2.813 Homo sapiens adrenergic, alpha-2C-, receptor (ADRA2C) TMSL3 NM_021109 9.07E-03 1.48E-01 2.782 Homo sapiens thymosin beta 4, X-linked (TMSB4X) PLA2G2A NM_000300 2.14E-02 1.82E-01 2.782 Homo sapiens phospholipase A2, group IIA (platelets, synovial fluid) (PLA2G2A), transcript variant 1 MECOM NM_001164000 2.14E-02 1.82E-01 2.779 Homo sapiens MDS1 and EVI1 complex locus (MECOM), transcript variant 6 D4S234E NM_014392 6.95E-03 1.42E-01 2.777 Homo sapiens DNA segment on chromosome 4 (unique) 234 expressed sequence (D4S234E), transcript variant 1 ELMOD1 NM_018712 1.96E-02 1.78E-01 2.775 Homo sapiens ELMO/CED-12 domain containing 1 (ELMOD1), transcript variant 1 TMEM100 NM_018286 3.32E-03 1.32E-01 2.771 Homo sapiens transmembrane protein 100 (TMEM100), transcript variant 2 FOXL2 NM_023067 1.30E-02 1.60E-01 2.759 Homo sapiens forkhead box L2 (FOXL2) PLXNC1 NM_005761 8.71E-04 1.17E-01 2.757 Homo sapiens plexin C1 (PLXNC1), transcript variant 1 TNNT1 NM_003283 2.59E-02 1.93E-01 2.741 Homo sapiens troponin T type 1 (skeletal, slow) (TNNT1), transcript variant 1 BEX5 NM_001012978 1.97E-03 1.23E-01 2.701 Homo sapiens brain expressed, X-linked 5 (BEX5), transcript variant 1 PIGR NM_002644 3.01E-02 2.02E-01 2.679 Homo sapiens polymeric immunoglobulin receptor (PIGR) TMEM151B NM_001137560 1.67E-02 1.72E-01 2.666 Homo sapiens transmembrane protein 151B (TMEM151B) MBNL2 NM_144778 6.32E-03 1.40E-01 2.627 Homo sapiens muscleblind-like 2 (Drosophila) (MBNL2), transcript variant 1 SHC3 NM_016848 2.64E-02 1.95E-01 2.627 Homo sapiens SHC (Src homology 2 domain containing) transforming protein 3 (SHC3) ANKRD34B NM_001004441 4.27E-02 2.30E-01 2.613 Homo sapiens ankyrin repeat domain 34B (ANKRD34B) PLCB2 NM_004573 2.19E-02 1.83E-01 2.607 Homo sapiens phospholipase C, beta 2 (PLCB2) F5 NM_000130 3.27E-02 2.09E-01 2.606 Homo sapiens coagulation factor V (proaccelerin, labile factor) (F5) PEG10 NM_001040152 3.13E-02 2.05E-01 2.560 Homo sapiens paternally expressed 10 (PEG10), transcript variant 1 GIPR NM_000164 4.35E-03 1.33E-01 2.540 Homo sapiens gastric inhibitory polypeptide receptor (GIPR) SYN2 NM_133625 8.78E-03 1.47E-01 2.529 Homo sapiens synapsin II (SYN2), transcript variant Iia SPACA5 NM_205856 4.87E-02 2.44E-01 2.522 Homo sapiens sperm acrosome associated 5 (SPACA5) ASPHD2 NM_020437 2.44E-02 1.89E-01 2.522 Homo sapiens aspartate beta-hydroxylase domain containing 2 (ASPHD2) FRY NM_023037 5.24E-03 1.37E-01 2.519 Homo sapiens furry homolog (Drosophila) (FRY) BMP7 NM_001719 1.26E-02 1.58E-01 2.518 Homo sapiens bone morphogenetic protein 7 (BMP7) PRX NM_181882 8.59E-03 1.47E-01 2.497 Homo sapiens periaxin (PRX), transcript variant 2 AKAP14 NM_001008535 2.88E-02 2.00E-01 2.496 Homo sapiens A kinase (PRKA) anchor protein 14 (AKAP14), transcript variant 3 PTPRC NM_002838 4.96E-02 2.46E-01 2.494 Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1 IL32 NM_001012631 3.26E-03 1.31E-01 2.489 Homo sapiens interleukin 32 (IL32), transcript variant 1 PI3 NM_002638 1.96E-03 1.23E-01 2.483 Homo sapiens peptidase inhibitor 3, skin-derived (PI3) ACSS1 NM_032501 3.58E-02 2.15E-01 2.483 Homo sapiens acyl-CoA synthetase short-chain family member 1 (ACSS1), nuclear gene encoding mitochondrial protein TMSB4X NM_021109 4.58E-03 1.33E-01 2.482 Homo sapiens thymosin beta 4, X-linked (TMSB4X) GNAI1 NM_002069 1.71E-04 9.50E-02 2.446 Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (GNAI1) SERPINA3 NM_001085 3.41E-02 2.11E-01 2.441 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 (SERPINA3) FCHSD2 NM_014824 2.76E-03 1.29E-01 2.432 Homo sapiens FCH and double SH3 domains 2 (FCHSD2) PLCG2 NM_002661 2.96E-02 2.01E-01 2.419 Homo sapiens phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2) OR9A2 NM_001001658 1.80E-02 1.75E-01 2.418 Homo sapiens olfactory receptor, family 9, subfamily A, member 2 (OR9A2) C20orf201 NM_001007125 2.20E-02 1.83E-01 2.403 Homo sapiens chromosome 20 open reading frame 201 (C20orf201) ENST00000372045 NM_001143981 3.74E-02 2.19E-01 2.400 Homo sapiens chordin-like 1 (CHRDL1), transcript variant 1 C18orf62 NM_001037331 9.15E-03 1.48E-01 2.395 Homo sapiens chromosome 18 open reading frame 62 (C18orf62) TMEM59L NM_012109 1.43E-02 1.64E-01 2.394 Homo sapiens transmembrane protein 59-like (TMEM59L) TECRL NM_001010874 3.10E-02 2.05E-01 2.388 Homo sapiens trans-2,3-enoyl-CoA reductase-like (TECRL) MRC2 NM_006039NM 006039 3.66E-023 66E 02 2.17E-012 17E 01 2.3832 383 HomoH sapiens i mannose receptor, t C type t 2 (MRC2) BIRC3 NM_001165 1.68E-02 1.72E-01 2.371 Homo sapiens baculoviral IAP repeat containing 3 (BIRC3), transcript variant 1 SOHLH2 NM_017826 1.03E-04 8.50E-02 2.365 Homo sapiens spermatogenesis and oogenesis specific basic helix-loop-helix 2 (SOHLH2) MAGEC2 NM_016249 3.79E-04 1.02E-01 2.360 Homo sapiens melanoma antigen family C, 2 (MAGEC2) ABCC8 NM_000352 5.65E-03 1.39E-01 2.359 Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (ABCC8) REEP1 NM_022912 1.94E-02 1.77E-01 2.357 Homo sapiens receptor accessory protein 1 (REEP1), nuclear gene encoding mitochondrial protein, transcript variant 2 LAMA3 NM_198129 1.20E-03 1.17E-01 2.354 Homo sapiens laminin, alpha 3 (LAMA3), transcript variant 1 MAGEC2 NM_016249 3.50E-03 1.32E-01 2.346 Homo sapiens melanoma antigen family C, 2 (MAGEC2) GUCY1B3 NM_000857 1.52E-02 1.67E-01 2.342 Homo sapiens guanylate cyclase 1, soluble, beta 3 (GUCY1B3) BEX1 NM_018476 4.43E-05 7.00E-02 2.341 Homo sapiens brain expressed, X-linked 1 (BEX1) BDKRB2 NM_000623 3.61E-02 2.16E-01 2.336 Homo sapiens bradykinin receptor B2 (BDKRB2) IL17C NM_013278 2.26E-02 1.84E-01 2.332 Homo sapiens interleukin 17C (IL17C) SNAI3 NM_178310 2.39E-02 1.88E-01 2.330 Homo sapiens snail homolog 3 (Drosophila) (SNAI3) OR10V1 NM_001005324 1.99E-02 1.79E-01 2.297 Homo sapiens olfactory receptor, family 10, subfamily V, member 1 (OR10V1) SYNE1 NM_182961 2.06E-02 1.80E-01 2.287 Homo sapiens spectrin repeat containing, nuclear envelope 1 (SYNE1), transcript variant 1 FUNDC1 NM_173794 2.50E-02 1.91E-01 2.287 Homo sapiens FUN14 domain containing 1 (FUNDC1) ARG1 NM_000045 9.02E-03 1.48E-01 2.286 Homo sapiens arginase, liver (ARG1) ADCY2 NM_020546 4.67E-03 1.34E-01 2.284 Homo sapiens adenylate cyclase 2 (brain) (ADCY2) GRIN3A NM_133445 1.64E-04 9.40E-02 2.282 Homo sapiens glutamate receptor, ionotropic, N-methyl-D-aspartate 3A (GRIN3A) C5orf42 NM_023073 1.79E-02 1.74E-01 2.280 Homo sapiens chromosome 5 open reading frame 42 (C5orf42) MAGEH1 NM_014061 3.13E-02 2.05E-01 2.264 Homo sapiens melanoma antigen family H, 1 (MAGEH1) AGXT2L1 NM_031279 2.33E-02 1.86E-01 2.254 Homo sapiens alanine-glyoxylate aminotransferase 2-like 1 (AGXT2L1), transcript variant 1 FAM65B NM_015864 1.62E-03 1.22E-01 2.253 Homo sapiens family with sequence similarity 65, member B (FAM65B), transcript variant 2 MEIS1 NM_002398 3.06E-03 1.30E-01 2.247 Homo sapiens Meis homeobox 1 (MEIS1) SLC30A3 NM_003459 1.15E-02 1.55E-01 2.228 Homo sapiens solute carrier family 30 (zinc transporter), member 3 (SLC30A3) PPP1R14C NM_030949 1.14E-02 1.54E-01 2.225 Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 14C (PPP1R14C) ZSWIM5 NM_020883 1.28E-02 1.59E-01 2.206 Homo sapiens zinc finger, SWIM-type containing 5 (ZSWIM5) SERPINA9 NM_175739 3.83E-02 2.21E-01 2.206 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 (SERPINA9), transcript variant A TNFAIP3 NM_006290 1.86E-02 1.75E-01 2.198 Homo sapiens tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) ZNF257 NM_033468 4.68E-02 2.39E-01 2.198 Homo sapiens zinc finger protein 257 (ZNF257) GDPD5 NM_030792 1.58E-02 1.69E-01 2.183 Homo sapiens glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) IL32 NM_001012633 2.02E-02 1.79E-01 2.169 Homo sapiens interleukin 32 (IL32), transcript variant 4 FAM198B NM_016613 1.01E-03 1.17E-01 2.168 Homo sapiens family with sequence similarity 198, member B (FAM198B), transcript variant 2 SYTL2 NM_206927 4.93E-03 1.35E-01 2.160 Homo sapiens synaptotagmin-like 2 (SYTL2), transcript variant c IL10RA NM_001558 2.98E-02 2.01E-01 2.159 Homo sapiens interleukin 10 receptor, alpha (IL10RA), transcript variant 1 GJB2 NM_004004 1.34E-02 1.61E-01 2.142 Homo sapiens gap junction protein, beta 2, 26kDa (GJB2) OLIG1 NM_138983 3.86E-02 2.22E-01 2.125 Homo sapiens oligodendrocyte transcription factor 1 (OLIG1) MANEA NM_024641 3.92E-03 1.33E-01 2.125 Homo sapiens mannosidase, endo-alpha (MANEA) GPR37L1 NM_004767 2.17E-02 1.82E-01 2.118 Homo sapiens G protein-coupled receptor 37 like 1 (GPR37L1) ATP1B1 NM_001677 3.26E-03 1.31E-01 2.101 Homo sapiens ATPase, Na+/K+ transporting, beta 1 polypeptide (ATP1B1) CXCR7 NM_020311 2.75E-03 1.29E-01 2.098 Homo sapiens chemokine (C-X-C motif) receptor 7 (CXCR7) GABBR1 NM_001470 1.86E-02 1.75E-01 2.095 Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1), transcript variant 1 TSHZ2 NM_173485 1.87E-02 1.75E-01 2.086 Homo sapiens teashirt zinc finger homeobox 2 (TSHZ2), transcript variant 1 RGS2 NM_002923 2.28E-02 1.85E-01 2.081 Homo sapiens regulator of G-protein signaling 2, 24kDa (RGS2) LZTS1 NM_021020 1.71E-02 1.73E-01 2.075 Homo sapiens leucine zipper, putative tumor suppressor 1 (LZTS1) NOS3 NM_000603 1.73E-02 1.73E-01 2.073 Homo sapiens nitric oxide synthase 3 (endothelial cell) (NOS3), transcript variant 1 NKX2-4 NM_033176 3.24E-02 2.08E-01 2.066 Homo sapiens NK2 homeobox 4 (NKX2-4) C2orf72 NM_001144994 2.69E-03 1.27E-01 2.065 Homo sapiens chromosome 2 open reading frame 72 (C2orf72) CAPN12 NM_144691 9.82E-03 1.50E-01 2.050 Homo sapiens calpain 12 (CAPN12) ZNF846 NM_001077624 3.79E-02 2.20E-01 2.049 Homo sapiens zinc finger protein 846 (ZNF846) GALNAC4S-6ST NM_015892 1.82E-02 1.75E-01 2.029 Homo sapiens carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 (CHST15), transcript variant 1 NPC1 NM_000271 9.16E-03 1.48E-01 2.025 Homo sapiens Niemann-Pick disease, type C1 (NPC1) NDRG4 NM_022910 1.78E-02 1.74E-01 2.021 Homo sapiens NDRG family member 4 (NDRG4), transcript variant 3 RALYL NM_173848 1.14E-03 1.17E-01 2.013 Homo sapiens RALY RNA binding protein-like (RALYL), transcript variant 3 CA5A NM_001739 2.72E-02 1.96E-01 2.010 Homo sapiens carbonic anhydrase VA, mitochondrial (CA5A), nuclear gene encoding mitochondrial protein PTGER4 NM_000958 1.91E-02 1.77E-01 2.010 Homo sapiens prostaglandin E receptor 4 (subtype EP4) (PTGER4) SAA2 NM_030754 4.61E-02 2.38E-01 2.006 Homo sapiens serum amyloid A2 (SAA2), transcript variant 1 FAM110C NM_001077710 2.43E-02 1.89E-01 2.005 Homo sapiens family with sequence similarity 110, member C (FAM110C) FRY NM_023037 1.66E-04 9.40E-02 2.004 Homo sapiens furry homolog (Drosophila) (FRY) NUDT7 NM_001105663 2.44E-02 1.89E-01 2.000 Homo sapiens nudix (nucleoside diphosphate linked moiety X)-type motif 7 (NUDT7), transcript variant 1 Supplementary Table S3: List of downregulated genes in NQO1 knockdown LNCaP cells

adj. p- Fold SeqName Earray_Refseq p-value value change Description NPM2 NM_182795 1.89E-04 9.90E-02 -66.349 Homo sapiens nucleophosmin/nucleoplasmin 2 (NPM2) CTAG1A NM_139250 2.18E-03 1.23E-01 -15.534 Homo sapiens cancer/testis antigen 1A (CTAG1A) DBC1 NM_014618 9.47E-04 1.17E-01 -11.377 Homo sapiens deleted in bladder cancer 1 (DBC1) MAGEC1 NM_005462 4.31E-03 1.33E-01 -10.051 Homo sapiens melanoma antigen family C, 1 (MAGEC1) NQO1 NM_000903 2.87E-03 1.29E-01 -7.532 Homo sapiens NAD(P)H dehydrogenase, quinone 1 (NQO1), transcript variant 1 NAP1L5 NM_153757 2.10E-02 1.81E-01 -7.483 Homo sapiens nucleosome assembly protein 1-like 5 (NAP1L5) RNF186 NM_019062 3.55E-02 2.15E-01 -6.176 Homo sapiens ring finger protein 186 (RNF186) CTAG2 NM_020994 1.40E-03 1.21E-01 -5.944 Homo sapiens cancer/testis antigen 2 (CTAG2), transcript variant 2 C5orf23 NM_001204375 2.93E-03 1.30E-01 -4.150 Homo sapiens natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) (NPR3), transcript variant 1 ID1 NM_002165 4.70E-04 1.07E-01 -4.105 Homo sapiens inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (ID1), transcript variant 1 NLGN1 NM_014932 4.55E-02 2.36E-01 -4.011 Homo sapiens neuroligin 1 (NLGN1) IGFBP3 NM_001013398 2.83E-04 9.90E-02 -3.749 Homo sapiens insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 1 IGFBP5 NM_000599 3.98E-02 2.24E-01 -3.656 Homo sapiens insulin-like growth factor binding protein 5 (IGFBP5) HPGD NM_000860 6.68E-04 1.12E-01 -3.572 Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), transcript variant 1 EAF2 NM_018456 6.34E-05 7.70E-02 -3.319 Homo sapiens ELL associated factor 2 (EAF2) PCDH20 NM_022843 1.72E-03 1.22E-01 -3.311 Homo sapiens protocadherin 20 (PCDH20) SEMA6A NM_020796 1.05E-02 1.51E-01 -3.271 Homo sapiens sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A (SEMA6A) KIF27 NM_017576 2.81E-02 1.98E-01 -3.237 Homo sapiens kinesin family member 27 (KIF27) SPAG17 NM_206996 2.98E-02 2.01E-01 -3.201 Homo sapiens sperm associated antigen 17 (SPAG17) ZDHHC15 NM_001146257 2.93E-02 2.01E-01 -3.180 Homo sapiens zinc finger, DHHC-type containing 15 (ZDHHC15), transcript variant 3 FMR1NB NM_152578 8.07E-03 1.45E-01 -3.118 Homo sapiens fragile X mental retardation 1 neighbor (FMR1NB) UBE3B NM_183415 2.92E-02 2.01E-01 -3.023 Homo sapiens ubiquitin protein ligase E3B (UBE3B), transcript variant 3 S100A10 NM_002966 3.63E-02 2.16E-01 -2.868 Homo sapiens S100 calcium binding protein A10 (S100A10) LAMC1 NM_002293 4.29E-04 1.03E-01 -2.845 Homo sapiens laminin, gamma 1 (formerly LAMB2) (LAMC1) ADRA2A NM_000681 2.75E-04 9.90E-02 -2.821 Homo sapiens adrenergic, alpha-2A-, receptor (ADRA2A) IGF1 NM_000618 1.57E-02 1.69E-01 -2.756 Homo sapiens insulin-like growth factor 1 (somatomedin C) (IGF1), transcript variant 4 CSGALNACT2 NM_018590 1.64E-02 1.71E-01 -2.746 Homo sapiens chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) GPR133 NM_198827 1.13E-03 1.17E-01 -2.718 Homo sapiens G protein-coupled receptor 133 (GPR133) DLX3 NM_005220 4.76E-02 2.41E-01 -2.677 Homo sapiens distal-less homeobox 3 (DLX3) EMID2 NM_133457 2.74E-02 1.97E-01 -2.676 Homo sapiens EMI domain containing 2 (EMID2) TARP NM_001003799 5.30E-03 1.37E-01 -2.668 Homo sapiens TCR gamma alternate reading frame protein (TARP), nuclear gene encoding mitochondrial protein, transcript variant 1 NEK10 NM_199347 1.29E-02 1.59E-01 -2.633 Homo sapiens NIMA (never in mitosis gene a)- related kinase 10 (NEK10) HES1 NM_005524 1.54E-02 1.68E-01 -2.574 Homo sapiens hairy and enhancer of split 1, (Drosophila) (HES1) FAR2 NM_018099 4.94E-02 2.45E-01 -2.566 Homo sapiens fatty acyl CoA reductase 2 (FAR2) HGD NM_000187 4.74E-04 1.07E-01 -2.549 Homo sapiens homogentisate 1,2-dioxygenase (HGD) MDGA1 NM_153487 6.03E-03 1.39E-01 -2.539 Homo sapiens MAM domain containing glycosylphosphatidylinositol anchor 1 (MDGA1) PLEKHG4B NM_052909 4.64E-02 2.38E-01 -2.535 Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 4B (PLEKHG4B) XAGE1D NM_001097592 4.37E-05 7.00E-02 -2.498 Homo sapiens X antigen family, member 1A (XAGE1A) GPC6 NM_005708 4.77E-02 2.41E-01 -2.455 Homo sapiens glypican 6 (GPC6) LPHN2 NM_012302 1.63E-02 1.71E-01 -2.440 Homo sapiens latrophilin 2 (LPHN2) TRPM8 NM_024080 9.52E-03 1.49E-01 -2.408 Homo sapiens transient receptor potential cation channel, subfamily M, member 8 (TRPM8) FAM135A NM_020819 3.56E-02 2.15E-01 -2.406 Homo sapiens family with sequence similarity 135, member A (FAM135A), transcript variant 2 TMEM154 NM_152680 4.58E-02 2.37E-01 -2.383 Homo sapiens transmembrane protein 154 (TMEM154) GNB4 NM_021629 2.23E-03 1.24E-01 -2.369 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 4 (GNB4) FN1 NM_054034 2.54E-03 1.26E-01 -2.341 Homo sapiens fibronectin 1 (FN1), transcript variant 7 CHRND NM_000751 8.10E-03 1.45E-01 -2.321 Homo sapiens cholinergic receptor, nicotinic, delta (CHRND) LYG2 NM_175735 1.87E-03 1.22E-01 -2.317 Homo sapiens lysozyme G-like 2 (LYG2) CYP1A1 NM_000499 1.10E-02 1.52E-01 -2.297 Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) SERPIND1 NM_000185 1.56E-02 1.69E-01 -2.297 Homo sapiens serpin peptidase inhibitor, clade D (heparin cofactor), member 1 (SERPIND1) ARMC4 NM_018076 4.56E-02 2.37E-01 -2.292 Homo sapiens armadillo repeat containing 4 (ARMC4)

ST6GALNAC1 NM_018414 1.26E-02 1.58E-01 -2.277 Homo sapiens ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (ST6GALNAC1) ZMAT3 NM_022470 1.81E-03 1.22E-01 -2.277 Homo sapiens zinc finger, matrin-type 3 (ZMAT3), transcript variant 1 FAM19A2 NM_178539 1.97E-02 1.78E-01 -2.262 Homo sapiens family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 (FAM19A2) C16orf71 NM_139170 4.53E-02 2.36E-01 -2.252 Homo sapiens chromosome 16 open reading frame 71 (C16orf71) NLGN1 NM_014932 1.62E-02 1.70E-01 -2.245 Homo sapiens neuroligin 1 (NLGN1) APOF NM_001638 3.07E-02 2.04E-01 -2.225 Homo sapiens apolipoprotein F (APOF) STAG1 NM_005862 1.44E-02 1.65E-01 -2.225 Homo sapiens stromal antigen 1 (STAG1) MT2A NM_005953 5.87E-03 1.39E-01 -2.216 Homo sapiens metallothionein 2A (MT2A) SPTBN4 NM_020971 1.21E-03 1.17E-01 -2.199 Homo sapiens spectrin, beta, non-erythrocytic 4 (SPTBN4), transcript variant sigma1 TARP NM_001003799 2.21E-03 1.24E-01 -2.197 Homo sapiens TCR gamma alternate reading frame protein (TARP), nuclear gene encoding mitochondrial protein, transcript variant 1 ALB NM_000477 2.92E-05 7.00E-02 -2.175 Homo sapiens albumin (ALB) ZNF367 NM_153695 3.68E-02 2.17E-01 -2.161 Homo sapiens zinc finger protein 367 (ZNF367) CR610885 NM_001008495 1.21E-03 1.17E-01 -2.134 Homo sapiens transmembrane protein 64 (TMEM64), transcript variant 1 UPB1 NM_016327 5.46E-03 1.38E-01 -2.122 Homo sapiens ureidopropionase, beta (UPB1) SPINK8 NM_001080525 3.60E-03 1.32E-01 -2.108 Homo sapiens serine peptidase inhibitor, Kazal type 8 (putative) (SPINK8) PRDM16 NM_199454 3.33E-02 2.10E-01 -2.107 Homo sapiens PR domain containing 16 (PRDM16), transcript variant 2 EPM2A NM_001018041 3.42E-02 2.11E-01 -2.101 Homo sapiens epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) (EPM2A), transcript variant 2 TBX15 NM_152380 2.93E-02 2.01E-01 -2.099 Homo sapiens T-box 15 (TBX15) PRNP NM_000311 2.57E-04 9.90E-02 -2.093 Homo sapiens prion protein (PRNP), transcript variant 1 FAM135A NM_020819 2.14E-02 1.82E-01 -2.091 Homo sapiens family with sequence similarity 135, member A (FAM135A), transcript variant 2 C6orf57 NM_145267 3.86E-03 1.33E-01 -2.076 Homo sapiens chromosome 6 open reading frame 57 (C6orf57) NBL1 NM_001204088 6.98E-03 1.42E-01 -2.068 Homo sapiens C1ORF15-NBL1 readthrough (C1orf15-NBL1), transcript variant 1 ARL4A NM_005738 1.71E-02 1.73E-01 -2.061 Homo sapiens ADP-ribosylation factor-like 4A (ARL4A), transcript variant 1 PLAC1 NM_021796 4.70E-02 2.40E-01 -2.050 Homo sapiens placenta-specific 1 (PLAC1) C6orf25 NM_025260 5.67E-03 1.39E-01 -2.030 Homo sapiens chromosome 6 open reading frame 25 (C6orf25), transcript variant 1 NAT8B NM_016347 2.89E-02 2.00E-01 -2.022 Homo sapiens N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene) (NAT8B) MON2 NM_015026 1.10E-02 1.52E-01 -2.012 Homo sapiens MON2 homolog (S. cerevisiae) (MON2) FAM3B NM_058186 1.48E-03 1.21E-01 -2.006 Homo sapiens family with sequence similarity 3, member B (FAM3B), transcript variant 1