Nootropics: Boost Body and Brain? Report #2445

NOOTROPICS: BOOST BODY AND BRAIN? REPORT #2445 BACKGROUND: Nootropics were first discovered in 1960s, and were used to help people with motion sickness and then later were tested for memory enhancement. In 1971, the nootropic drug piracetam was studied to help improve memory. Romanian doctor Corneliu Giurgea was the one to coin the term for this drug: nootropics. His idea after testing piracetam was to use a Greek combination of “nous” meaning mind and “trepein” meaning to bend. Therefore the meaning is literally to bend the mind. Since then, studies on this drug have been done all around the world. One test in particular studied neuroprotective benefits with Alzheimer’s patients. More tests were done with analogues of piracetam and were equally upbeat. This is a small fraction of nootropic drugs studied over the past decade. Studies were done first on animals and rats and later after results from toxicity reports, on willing humans. (Source: https://www.purenootropics.net/general-nootropics/history-of-nootropics/) A COGNITIVE EDGE: Many decades of tests have convinced some people of how important the drugs can be for people who want an enhancement in life. These neuro-enhancing drugs are being used more and more in the modern world. Nootropics come in many forms and the main one is caffeine. Caffeine reduces physical fatigue by stimulating the body’s metabolism. The molecules can pass through the blood brain barrier to affect the neurotransmitters that play a role in inhibition. These molecule messengers can produce muscle relaxation, stress reduction, and onset of sleep. Caffeine is great for short–term focus and alertness, but piracetam is shown to work for long-term memory. Piracetam enhances brain oxygen supply and the removal of the inhibitory transmitter GABA, thus theoretically improving attention, memory, and learning. While, there are supplements such as alpha GPC or choline bitartrate for piracetam users, choline is also found in some foods such as vegetables and eggs leading to the theory that a vegetarian diet leads to mental acuity. Modafinil is a prescription drug traditionally used to treat narcolepsy. Narcolepsy is an uncommon neurological disorder where individuals are susceptible to repeated sleep throughout the day. Modafinil elevates levels of histamine in the hypothalamus. This leads to a greater amount of alertness. Military pilots have been given this medication for long missions. (Source: https://www.purenootropics.net/general-nootropics/history-of-nootropics/) and https://www.psychologytoday.com/blog/the-fallible-mind/201610/silver-bullets-your-brain-nootropics-are-now- hand) PRECAUTIONS: Nootropics are sold as nutritional supplements and natural products and refrain from making health claims causing them to avoid close government scrutiny. Piracetam is only one of many formulations in the racetam drug family. Newer ones include aniracetam, phenylpiracetam and oxiracetam and all are available on line where their efficacy and safety are debated and reviewed on message boards and in podcasts. If you are taking Adderall, albuterol or piracetam, you could be at risk for high blood pressure and heart problems. Vinh Ngo, MD, a San Francisco family practice doctor who specializes in hormone therapy, requires his patients to sign waivers acknowledging possible health risks in taking nootropics. While studies have found short-term benefits, Professor Murali Doraiswamy, who has led several trials of cognitive enhancers at Duke University Health System, told The New York Times “there is no evidence that what are commonly known as smart drugs, of any type, improve thinking or productivity over the long run. That’s because when you up one circuit in the brain, you’re probably impairing another system.” (Source: https://www.psychologytoday.com/blog/the-fallible-mind/201610/silver-bullets-your-brain-nootropics- are-now-hand) For More Information, Contact: Vinh Ngo, MD Smart Medicine SF www.smartmedsf.com [email protected] 415-598-7633 Free weekly e-mail on Medical Breakthroughs from Ivanhoe. To sign up: http://www.ivanhoe.com/ftk.

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