Anti-EMR2 Monoclonal Antibody, Clone 2A1 [FITC] (CABT-52823MH) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-EMR2 monoclonal antibody, clone 2A1 [FITC] (CABT-52823MH) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Mouse anti Human CD312 antibody, clone 2A1 recognizes human EMR2, a member of the epidermal growth factor-seven transmembrane (EGF-TM7) family of proteins, which is closely related to CD97. EMR2, also known as CD312, is predominantly expressed on myeloid dendritic cells, monocytes and tissue macrophages. Various isoforms of EMR2 have been documented. The ligand for the largest isoform of EMR2 has recently been identified as chrondroitin sulphate, which binds to the fourth EGF-like module of EMR2. Clone 2A1 specifically recognizes the stalk region of EMR2. Flow Cytometry Use 10ul of the suggested working dilution to label 106 cells in 100ul.

Specificity EMR2

Immunogen NIH-3T3 cells stably transfected with EMR2 (EGF1-5) cDNA

Isotype IgG1

Source/Host Mouse

Species Reactivity Human

Clone 2A1

Conjugate FITC

Applications FC

Procedure Conjugated Antibodies

Format Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid

Size 100 μg

Preservative See individual product datasheet

Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Warnings For research purposes only

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Gene Name EMR2 egf-like module containing, mucin-like, hormone receptor-like 2 [ Homo sapiens (human) ]

Official Symbol EMR2

Synonyms EMR2; egf-like module containing, mucin-like, hormone receptor-like 2; CD312; EGF-like module-containing mucin-like hormone receptor-like 2;

Entrez Gene ID 30817

Protein Refseq NP_001257981

UniProt ID Q9UHX3

Chromosome Location 19p13.1

Pathway Class B/2 (Secretin family receptors); Defective ACTH causes Obesity and Pro- opiomelanocortinin deficiency (POMCD); Disease; GPCR ligand binding; GPCRs, Class B Secretin-like; GPCRs, Other; Metabolic disorders of biological oxidation enzymes; Signal Transduction;

Function G-protein coupled receptor activity; calcium ion binding; chondroitin sulfate binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]