WUOF2015 Version July 27, 2015 agenda OLD PATHWAYS, NEW JOURNEYS IN UROLOGIC ONCOLOGY Conference Co-Chairs | Nathan Lawrentschuk, MD and Laurence Klotz, MD WELCOME & INTRODUCTIONS 7:00 Meet and Greet International Colleagues (coffee and refreshments served) 7:45 Co-Chairmen’s Welcome & Framing of Theme | Laurence Klotz & Nathan Lawrentschuk

7:50 SESSION ONE | LOCALIZED PROSTATE CANCER | Co-Moderators: Mark Frydenberg & Laurence Klotz 7:55 *USPSTF and **CTFPHE vs Consensus: How Do We Reconcile? | Nathan Lawrentschuk, MD | Australia 8:07 Neoadjuvant Therapy Before Radical Prostatectomy: Current and Future Role | James Eastham, MD | USA 8:19 Role of 5ARIs in Men on Surveillance | Neil Fleshner, MD | Canada 8:31 Should Race Impact the Decision to Offer Active Surveillance? | Judd Moul, MD | USA 8:43 DISCUSSION 8:58 High Risk Features and Genomic Instability in Men with Familial Prostate Cancer | Gail Risbridger, PhD | Australia 9:10 Focal Therapy: Current Status | Damien Bolton, MD | Australia 9:22 Is Radiation as Good as Surgery for Young Men with Intermediate and High Risk Prostate Cancer? | Laurence Klotz, MD | Canada 9:34 How Morbid is Radiation Compared to Surgery? | Robert Nam, MD | Canada 9:46 DISCUSSION

10:00 BREAK

10:10 SESSION TWO | PROSTATE CANCER | Co-Moderators: Nathan Lawrentschuk & Marcelo Bendhack 10:12 Role of PSMA PET CT in Biochemical Recurrence and High Risk Localized PCA | Nathan Lawrenstchuk, MD | Australia 10:25 Adjuvant vs Early Salvage Radiation: Still a Controversy? | Stephen Boorjian, MD | USA 10:49 The Role of Radical Prostatectomy in Men with Advanced Prostate Cancer | Manish Patel, MD | Australia 10:55 AR in Prostate Cancer | Wayne Tilley, PhD | Australia 11:10 DISCUSSION

11:25 SESSION THREE | TESTIS CANCER | Moderator: Shrawan Singh Melbourne, Australia South Wharf VIC 3006 1 Convention Centre Place Melbourne Convention and Exhibition Centre Room 204 October 15, 2015 11:30 Non-Risk Adapted Surveillance For All Clinical Stage One Testicular Cancer | Michael Jewett, MD | Canada 11:45 DISCUSSION

12:00 BREAK & LUNCH SERVICE Gourmet Catered Lunch Provided by Café Vue. Complimentary to All Seated Participants Attending Session Four Working Lunch

12:25 SESSION FOUR | A PROVOCATIVE DISCUSSION | Co-Moderators | Laurence Klotz & Peter Hammerer MAJOR OBSERVATIONS: Objectives: Three key opinion leaders will identify the single most major observation in their fi eld within the last 3 years. Each presenter will have 4 minutes to describe the observation, 4 minutes to put this into context and 4 minutes to receive and respond to comments from the Critique Panel. Critique Panel | Peter Hammerer, Laurence Klotz, James Eastham PRESENTATIONS: Observation #1 | Title | Mark Frydenberg | Australia Observation #2 | Title | Badrinath Konety | USA Observation #3 | Title | Claus Roehrborn | USA 1:05 DISCUSSION

1:15 SESSION FIVE | KIDNEY CANCER | Moderator: Michael Jewett 1:20 KIDNEY ONE: A CLINICAL CASE IN KIDNEY CANCER International Perspectives on Clinical Management of Kidney Cancer CASE: 65 Year Old Male with a 4 cm Central Renal Mass Three (5 minute) case discussions, justifying each approach. DISCUSSANTS: • Antonio Finelli, MD | Canada | (5 min) • Alessandro Volpe, MD | Italy | (5 min) • Gennady Bratslavsky, MD | USA | (5 min) DISCUSSION (15 min)

1:50 KIDNEY TWO: PANEL DISCUSSION PEARLS OF KIDNEY SURGERY: WHAT IS MY SINGLE MOST HELPFUL TECHNIQUE? Conference Co-Chairs: (Panelists: Antonio Finelli, Alessandro Volpe, Gennady Bratslavsky) Laurence Klotz, MD WUOF Chairman 2:10 BREAK (Canada) Nathan Lawrentschuk, MD 2:20 SESSION SIX | BLADDER CANCER | Co-Moderators: Maurizio Brausi & Arnulf Stenzl (Australia) 2:25 Metanomic Profi ling of Bladder Cancer | Kesavan Esuvaranathan | Singapore 2:35 The Cancer Genome Atlas Project – Translational Opportunities in Bladder Cancer | Seth Lerner, MD | USA 2:45 Management of Bladder Cancer and Urinary Diversions in Low Resource Environments | Makarand Khochikar, MD | India 2:55 DISCUSSION

3:05 Point-Counter-Point: Neo Adjuvant vs Adjuvant Bladder Cancer: Which One is Preferable? 3:15 Neoadjuvant | Wassim Kassouf, MD | Canada 3:25 Adjuvant | John Davis, MD | USA 3:35 DISCUSSION

3:45 ADJOURN +61 3 9235 8000 *USPSTF: US Preventive Service Task Fore **CTFPHE: Canadian Task Force on the Periodic Health Examination www.wuof.org WUOF2015 Member Societies This meeting has been made possible by funding from our exhibitors and sponsors: Asian-Pacifi c Society of Urologic Oncology Australian Urologic Oncology Section GOLD sponsor BAUS-Urologic Oncology Section Canadian Uro-Oncology Group Chinese Urologic Oncology Group European Society of Urologic Oncology German Society of Urological Oncology SILVER sponsors Indian Urological Society Israeli Society of Urologic Oncology Italian Society of Urologic Oncology Japanese Urological Association Korean Society of Urologic Oncology Latin American Society of Urologic Oncology BRONZE sponsors Mexican Society of Uro-Oncology With appreciation Philippines Society of Urologic Oncology Society of Urologic Oncology (North America) Turkish Urologic Oncology Society

October 15, 2015 Old Pathways, Melbourne Convention and Exhibition Centre New Journeys in 1 Convention Centre Place South Wharf VIC 3006 Urologic Oncology Melbourne, Australia

FACULTY & PARTICIPANTS: Australia Canada India Prof. Damien M Bolton, BA, MBBS, MD, Antonio Finelli, MD, MSc, FRCSC Dr. Makarand Khochikar James Eastham, MD FRCS, FRACS Urologic Oncology/Minimally Invasive MS DNB (Urology), FRCS (Urology) FEBU Chief, Urology Service Director of Urology, Austin Health Surgery Chairman and Chief of Uro-Oncology Florence and Theodore Baumritter/Enid Department of Surgical Oncology Shri Siddhi Vinayak Ganapari Cancer Hospital Ancell Chair Department of Surgery, Princess Margaret Hospital (UHN) Miraj Memorial Sloan Kettering Cancer Center Olivia Newton-John Cancer and Associate Professor, University of Toronto New York, New York Dr. Shrawan K Singh, MS, MCh, FAMS Wellness Centre, Neil Fleshner, MD, MPH, FRCSC Professor of Urology Badrinath Konety, MD, FACS, MBA Melbourne, Australia Professor of Surgery Post Graduate Professor and Chair Mark Frydenberg, MD, MBBS, Martin Barkin Chair of Urology Institute of Medical Education & Research Department of Urology FRACS (Urology) Chairman University of Toronto Chandigarh University of Minnesota Uro-oncology Special Advisory Group Head, Division of Urology Minneapolis, Minnesota Urological Society of Australia & University Health Network Italy Seth P. Lerner, MD, FACS New Zealand Associate Professor Love Chair in Prostate Cancer Prevention Maurizio Brausi, MD Professor, Scott Department of Urology Dept Surgery Faculty of Medicine Princess Margaret Hospital Professor and Chairman of Urology Beth and Dave Swalm Chairman, Michael Jewett, MD Ausl Modena, Chairman ESOU Chair in Urologic Oncology Dept Urology, Department of Surgical Oncology (Urology) Chairman Bladder Cancer Group SIU Director of Urologic Oncology Chairman, Clinical Institute of Specialty Princess Margaret Hospital/University (Italian Society of Urology) Director of the Multidisciplinary Surgery, Epworth Healthcare Health Network Faculty Member ESU Bladder Cancer Program A/Prof Nathan Lawrentschuk, Professor, Department of Surgery (Urology) (European School of Urology) Faculty Group Practice Medical Director MD, MB BS, PhD, FRACS (Urology) University of Toronto Alessandro Volpe, MD Baylor College of Medicine, University of Melbourne Houston, Texas Wassim Kassouf, MD, CM, FRCSC Associate Professor of Urology Department of Surgery Associate Professor and Program Director University of Eastern Piedmont Judd W. Moul, MD, FACS Austin Hospital and Department McGill University Health Centre Maggiore della Carità Hospital James H. Semans, MD Professor of Surgery of Surgical Oncology Montreal, Quebec Novara Director, Duke Prostate Center Peter MacCallum Cancer Centre Division of Urologic Surgery Olivia Newton-John Cancer Laurence Klotz, MD, CM Singapore Duke University Medical Center Research Institute Professor of Surgery, University of Toronto Durham, North Carolina Melbourne Chairman, WUOF Professor Kesavan Esuvaranathan, Chairman, CURC MD, FRCSED, FRCSG, FAMS (Urol) Claus G Roehrborn, MD A/Prof Manish I. Patel Associate Editor, Journal of Urology Professor & Head Department of Urology Professor and Chair MBBS MMed PhD FRACS (Urology) Division of Urology University Surgical Cluster S.T. Harris Family Chair in Medical Urological Cancer Surgeon Sunnybrook Health Sciences Centre National University Hospital of Singapore Science, in Honor of John D. McConnell, M.D. University of Sydney E.E. Fogelson and Greer Garson Fogelson Westmead and Macquarie University Robert Nam, MD, FRCSC United States of America Distinguished Chair in Urology Hospitals Ajmera Family Chair in Urologic Oncology Stephen Boorjian, MD, FACS Department of Urology Professor of Surgery Professor Gail P. Risbridger Professor of Urology UT Southwestern Medical Center at Dallas University of Toronto Prostate Cancer Research Program Vice Chair of Research, Dept of Urology Dallas, TX 75390-9110 Head, Genitourinary Cancer Site Deputy Dean, Special Projects Director, Urologic Oncology Fellowship Odette Cancer Centre MCCC Research Director Mayo Clinic Sunnybrook Health Sciences Centre Monash University, Rochester, Minnesota Melbourne Germany Gennady Bratslavksy, MD Wayne Tilley, PhD Professor Dr. Peter Hammerer Professor & Chair Director, Dame Roma Mitchell Cancer Chefarzt Klinik für Urologie Department of Urology Research Laboratories und Uroonkologie SUNY Upstate Medical University Freemasons Foundation Centre Klinikum Braunschweig Syracuse, New York for Men’s Health John W. Davis, MD, FACS School of Medicine, Faculty of Health Sciences Arnulf Stenzl, MD Associate Professor, Urology The University of Adelaide Professor and Chairman Department of Urology Director, Urosurgical Prostate Program Brasil University Medical Clinic Tuebingen MD Anderson Cancer Center Director Scientifi c Offi ce European Houston, Texas, USA Professor Marcelo L. Bendhack, MD Association of Urology Associate Editor, Urologic Oncology, Professor of Urology British Journal of Urology International Positivo University, Curitiba Director Uro-Oncologia do Brasil Clinic President Latin American Society of Uro-Oncology