Faculty of Chemical Technology and Biotechnology Budapest University of Technology and Economics

FACULTY OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS

The education of chemical engineers and chemists has a long-standing tradition in Hungary. Hungary’s earliest chemistry department was established in 1763 at the Selmecbánya Mining School, the first school to offer practical instruction in the chemical laboratory. In 1769, a common department for chemistry and botany was founded at the University of Nagyszombat, which was resettled to Buda in 1777 and later to Pest. In 1846, the Department of General and Technical Chemistry was founded at Joseph II Industrial School, one of the Budapest University of Technology and Economics’s predecessor institutions. Education of chemical engineers, separate from that of mechanical and civil engineers, reaches back to the 1863/64 academic year. Royal Joseph Polytechnic became a technical university in 1871. The academic freedom introduced by this university-level status allowed students to freely select the subjects they wished to study. However, the need for an interrelated, logical sequence of subjects soon became evident, so in 1892 a compulsory curriculum and timetable was introduced. From the foundation of the Faculty until 1948, only a four-year- term of studies, without specialisations, was offered. Following the educational reforms of 1948, the departments of Inorganic Chemical Technology, Organic Chemical Technology, and Agricultural and Food Chemistry were established. The Inorganic Chemical Technology Department is no longer a part of the Faculty because in 1952 its tasks were taken over by the University of Chemical Industry in Veszprém. Further reforms in the 1960s extended chemical engineering studies to the M.Sc. level and introduced the range of specialised studies identified below. A Ph.D. program has also been established. Studies in English at the Faculty of Chemical Engineering began in the 1985/86 academic year. Students in the BSc program receive a thorough introduction to areas basic to chemical engineering before they begin their specialisations in the fifth semester. Courses of the following branches are available to students depending on the number of applicants (at least 3 applicants) both at the B.Sc. and M.Sc. levels: • Analytical and Structural Chemistry • Polymer Technology • Chemical and Process Engineering • Textile Technology • Industrial Pharmaceutics

The M.Sc. program will start in February 2011.

62 FACULTY OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

The Faculty of Chemical Technology and Biotechnology aims for its students to acquire a profound theoretical knowledge in mathematics, physics and physical chemistry. It also aims to have its students experience, during their studies, all the types of tasks that chemical engineers encounter in their practical every- day work. Students will acquire up-to-date laboratory skills, get acquainted with the machines and appa- rati used in the chemical industry, know the principles needed for their optimal operation, and develop expertise in a more specific technology within the chemical, food and light industries. Graduates of this Faculty will be versed in: • The operations and personnel involved in chemical processes on an industrial scale, • The development of the technology and products of industrial chemical processes, • The design of industrial chemical processes, • How a chemical product or application is introduced into the national economy, and • The elaboration of new chemical processes, operations and technologies. A three-year Ph.D. program is also available in all majors offered by the Faculty. Departments Department of Inorganic and Analytical Chemistry Department of Physical Chemistry and Materials Science Department of Organic Chemistry and Technology Department of Chemical and Environmental Process Engineering Department of Applied Biotechnology and Food Science

Budapest University of Technology and Economics Faculty of Chemical Technology and Biotechnology Faculty Office: Dean of the Faculty: Prof. Dr. György Pokol Building Z, 2nd Floor, Room No. 201. Course Director: Dr. Zoltán Hell Mailing Address: Mûegyetem rakpart 3-9. Program Co-ordinator: Ms. Gyöngyi Tamás H-1521 Budapest, P.O. Box 91. Hungary E-mail: [email protected] Phone: (+36-1) 463-4140 Fax: (+36-1) 463-2460 63 BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS

Curriculum of B.Sc. Subjects General Subjects Subject working hours / week Requisites Name Code Credits 1 2 3 4 5 6 7 8 Compulsory English I. BMEGT63A301 2 0/4/0p Compulsory English II. BMEGT63A302 2 0/4/0p BMEGT63A301 English for Engineers BMEGT63A051 2 0/2/0p BMEGT63A302 Communication Skills - English OR BMEGT63A061 2 0/2/0p BMEGT63A051 Manager Communication -English OR BMEGT63A081 2 0/2/0p BMEGT63A051 Intercultural Communication - English BMEGT63A091 2 0/2/0p BMEGT63A051 Mathematics A1a - Calculus BMETE90AX00 6 4/2/0/e General Chemistry BMEVESAA101 5 4/0/0e General Chemistry Calculations BMEVESAA102 4 0/4/0p General Chemistry Laboratory Practice BMEVESEA103 4 0/0/4p Computing BMEVESAA103 2 0/2/0p Mechanical Operations in Chemical Industry BMEGEVGAV01 3 2/0/0e Mechanical Operations in Ch. Industry Pract. BMEGEVGAV02 2 0/1/2 Micro- and Macroeconomics BMEGT30A001 4 4/0/0e Mathematics A2a - Vector Functions BMETE90AX02 6 4/2/0e BMETE90AX00 Foundations of Mathematical Statistics BMETE90AX14 2 2/0/0e Physics I Mechanics BMETE14AX10 2 2/0/0p Inorganic Chemistry BMEVESAA207 3 3/0/0e BMEVESAA101, VESAA102 Inorganic Chemistry Laboratory Practice BMEVESEA208 4 0/0/4p BMEVESAA101, VESAA102, BMEVESEA103 Organic Chemistry I BMEVESKA202 5 3/1/0e BMEVESAA101 Chemical Technology BMEVEKTA202 6 3/0/2p BMEVESAA101 English for Engineers BMEGT63A051 0 2/0/0s BMEGT63A301 Physics I Electrodynamics BMETE14AX04 2 2/0/0e BMETE90AX02, TE14AX10 Physics Laboratory BMETE14AX11 2 0/0/2p BMETE14AX10, TE90AX14 Organic Chemistry II BMEVESKA303 5 3/1/0e BMEVESKA202 Analytical Chemistry BMEVEAAA302 5 3/1/0p BMEVESAA207, VESKA202 Physical Chemistry I BMEVEFKA304 5 3/1/0e BMETE90AX02, VESAA101 Polymers BMEVEMGA306 5 2/0/2e BMEVESKA202 Organic Synthesis Laboratory Practice BMEVESKA307 5 0/0/5p BMEVESEA103, VESAA102, BMEVESKA202 Analytical Chemistry Laboratory Practice BMEVEAAA403 4 0/0/4p BMEVEAAA302, VESEA208 Physical Chemistry II BMEVEFAA405 4 2/1/0e BMEVEFKA304 Medicines BMEVESTA403 3 2/0/0p Colloid Chemical Principles of Nanotechn. BMEVEFAA409 3 3/0/0e BMEVEFKA304 Environmental Chemistry and Technology BMEVEKFA403 4 3/0/0p BMEVESAA207, VESKA303, BMEVEKTA202 Organic Chemical Technology BMEVESTA411 3 2/0/0e BMEVESKA202, GEVGAV101, BMEGEVGAV02 Organic Chemical Technology Labo. Practice BMEVESTA412 3 0/0/3p BMEVESKA202, GEVGAV01, BMEGEVGAV02 Chemical Unit Operations I BMEVEKFA410 6 3/2/0e BMETE90AX02, GEVGAV01, BMEGEVGAV02 Business Law BMEGT55A001 2 2/0/0p Biochemistry for Chemical Engineers BMEVEMBA503 4 3/0/0e BMEVESKA303 Physical Chemistry Laboratory Practice BMEVEFKA506 4 0/0/3p BMEVEFAA405, BMETE14AX11 Chemical Process Control BMEVEVMA504 5 2/1/1p BMEVEKFA410 Chemical Unit Operations II BMEVEVMA512 6 2/1/3e BMEVEKFAA410 Management and Business Economics BMEGT20A001 4 4/0/0p Safety Technology in the Chemical Industry BMEVESTA601 2 2/0/0p BMEGEVGAV01, GEVGAV02, BMEVESAA101 Quality Management BMEVEKFA615 2 2/0/0e Chemical Unit Operations Laboratory Pract. BMEVEKFA613 3 0/0/3p BMEVEVMA512 Electives (humanities) 8 4/0/0e2/0/0e2/0/0e Project work BMEVExxA777 3 0/1/0p Branch 25 7 credits9 credits9 credits Thesis BMEVExxA999 15 0/0/15 Summer Practice BMEVExxA888 0 6 weeks/s Elective 10 8/0/0e

64 FACULTY OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Curriculum of B.Sc. Branch Subjects

Subject working hours / week Requisites Name Code Credits 1 2 3 4 5678 Branch of Analytical and Structural Chemistry Analytical and Structure Determination Lab. BMEVEAAA604 3 0/0/3p BMEVEAAA302, VEAAA403, BMEVEAAA512 Elemental Analysis BMEVEAAA507 3 2/0/0e BMEVEAAA403 Chemical and Biosensors BMEVEAAA708 3 2/0/0e BMEVEAAA403 Chromatography BMEVEAAA611 3 2/0/0e BMEVEAAA403 Organic Structure Analysis BMEVEAAA512 4 3/0/0p BMEVESKA303 Structural Chemistry BMEVEFKA708 4 3/0/0e BMETE90AX02, TE14AX04 Organic Chemistry III BMEVESKA504 2 2/0/0e BMEVESKA303 Design of Experiments BMEVEVMA606 3 2/1/0p BMETE90AX14 Branch of Chemical and Process Engineering Catalysis and Hydrocarbon Proc. Lab. Pract. BMEVEKTA505 3 0/0/3p BMEVESKA303, VEKFA410, BMEVEKFA202 Hydrocarbon Processing BMEVEKTA506 3 2/0/0e BMEVESKA303, VEKFA304, BMEVEKFA202 Process Engineering BMEVEVMA605 5 3/0/2e BMEVEVMA512 Design of Experiments BMEVEVMA606 3 2/1/0p BMETE90AX14 Environmental Benign Chemical Process BMEVEVMA607 4 3/0/0e Computer Process Control BMEVEVMA709 4 2/0/1e BMEVEVMA504 Chemical Production Control BMEVEKTA707 3 2/0/1p BMEVEKFA202, VEVMA512 Branch of Industrial Pharmaceutics Organic Structure Analysis BMEVEAAA512 4 3/0/0p BMEVESKA303 Organic Chemistry III BMEVESKA504 2 2/0/0e BMEVESKA303 Organic Chemistry Laboratory Practice II BMEVESKA605 5 0/0/6p BMEVESKA303, VESKA307 Industrial Planning Practice II BMEVESTA702 1 1/0/0 Pharmaceutical technology BMEVESTA704 2 2/0/0e BMEVESTA606 Unit Processes in Ind. Drug Synth. Lab. Pract. BMEVESTA705 4 0/0/5p BMEVESTA508 Unit Processes in Ind. Drug Synthesis BMEVESTA606 2 2/0/0e BMEVESTA508 Technology of Pharmaceutical Materials BMEVESTA607 3 2/0/1e BMEVESTA411 Unit Processes of Organic Chemistry BMEVESTA508 2 2/0/0e BMEVESTA411 Branch of Material Science Physical Chemistry of Surfaces BMEVEFKA603 3 2/0/0e BMEVEFAA409 Functional and Intelligent Materials BMEVEFKA707 5 2/0/2e BMEVEFAA405, VEFAA409, BMEVEMGA306 Chemistry and Technology of Macromolecul. BMEVEMGA504 2 2/0/0p BMEVEMGA306 Experimental Methods in Materials Science BMETE12AX12 2 2/0/0e Methods in Material Science Lab. Pract. BMEVEMGA502 3 0/0/4p Material Science Laboratory Practice BMEVEMGA603 3 0/0/4p Polymer Physics BMEVEMGA511 3 2/0/0e BMEVEMGA306 Metals, Ceramics and their Associated SystemsBMEVEMGA613 4 4/0/0e Branch of Polymer Technology Experimental Methods in Materials Science BMETE12AX12 2 2/0/0e Chemistry and Technology of Macromolecules BMEVEMGA504 2 2/0/0p BMEVEMGA306 Machines and Tools for Polymer Processing BMEVEMGA705 6 2/1/1e BMEVEMGA608 Polymer Processing BMEVEMGA608 7 4/0/5e BMEVEMGA511 Polymer Physics Laboratory Practice BMEVEMGA509 3 0/0/4p BMEVEMGA306 Polymer Additives BMEVEMGA610 2 2/0/0e BMEVEMGA306 Polymer Physics BMEVEMGA511 3 2/0/0e BMEVEMGA306 Branch of Textile Technology Experimental Methods in Material Science BMETE12AX12 2 2/0/0e Chemistry and Technology of Macromolecules BMEVEMGA504 2 2/0/0p BMEVEMGA306 Fibre Forming Polymers BMEVEMGA512 2 2/0/0p BMEVEMGA306 Chemistry of Dyes and Surfactants BMEVEMGA514 2 2/0/0p Colorimetry, Color Measurement BMEVEMGA515 2 2/0/0p Textile Chemistry Laboratory Practice BMEVEMGA716 3 0/0/3p BMEVEMGA617 Chemical Technology of Textiles I BMEVEMGA617 7 3/0/4e BMEVEMGA512 Chemical Technology of Textiles II BMEVEMGA718 3 2/0/0e BMEVEMGA617 Textile Mechanical Technology BMEVEMGA619 2 2/0/0p BMEVEMGA512

65 BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS

Curriculum of M.Sc. Subjects

Subject hours/week Name Code Credits 1 2 3 4 General Subjects Differential Equations 3 2/1/0e Complex and Organometallic Chemistry BMEVESAM101 2 2/0/0p Organic Chemistry BMEVESZM101 4 3/0/0e Analytical Chemistry BMEVESAM102 4 2/0/2p Materials science: BMEVEFAM101 4 2/0/2e traditional structural materials and polymers Chemical process design and control BMEVEKFM101 4 2/0/2p Economic Analysis of Technological Processes BMEGT30MS07 2 2/0/0e Project Work I BMEVExxM100 3 0/0/4p Design of Experiments BMEVEKFM203 3 2/1/0p Modern Physics for Chemical Engineers 3 3/0/0e Physical Chemistry and Structural Chemistry BMEVEFAM201 5 5/0/0e Technologies in Organic Chemical Industry BMEVESZM201 5 2/0/2e Technology Management BMEGT20M014 2 2/0/0e Environmentally Benign and Catalytic Proc. BMEVEKMF204 5 3/0/2e Project Work II BMEVExxM200 3 0/0/4p Biology, Biotechnology BMEVEMBM301 3 2/0/0p Computational Chemistry BMEVESAM301 3 2/0/1e Social and Visual Communication BMEGT43MS07 2 2/0/0e Thesis I BMEVExxM300 15 0/0/11p Branch-depend. Eco. and Human Know. Subj. 4 Elective Subject 6 Thesis II BMEVExxM400 15 0/0/11p Branch 20 M.Sc. Total: 120 Branch of Analytical and Structural Chemistry Analytical Chemistry III BMEVESAM201 5 1/0/4p Sample preparation and sampling BMEVESAM204 3 2/0/0p Structure Elucidation of Organic Compounds II. BMEVESAM303 5 3/1/0e Modern Separation Techniques BMEVESAM106 4 2/0/2e Bioanalysis and Study of Metabolites BMEVESAM204 3 2/0/0e Branch of Chemical and Process Engineering Process Modelling and Process Design BMEVEKFM101 4 2/0/2e Energy prod. with conv. and novel methods BMEVEKFM302 4 2/0/1p Modern Separation Technologies BMEVEKFM104 3 2/0/1p Industrial Organic Chemistry BMEVESZM204 3 0/2/1p Petrochemistry BMEVEKFM402 6 2/0/3e Branch of Industrial Pharmaceutics Pesticides BMEVESZM403 3 2/0/0e Pharmaceutical Technology BMEVESZM202 4 2/1/0e Formulation of Biologically Active Materials BMEVESZM404 4 0/2/2e Industrial Organic Chemistry BMEVESZM102 3 0/2/1p Medicinal Chemistry BMEVESZM203 6 3/0/2e Branch of Polymer Technology Application of Plastics BMEVEFAM402 5 3/0/1e Machines and Technologies in Polymer Proc. BMEVEFAM305 5 3/0/1p Polymer Physics BMEVEFAM202 4 3/0/0e Polyreactions BMEVEFAM102 3 2/0/0p Composites BMEVEFAM301 3 2/0/0e Branch of Textile Technology Polyreactions BMEVEFAM102 3 2/0/0p Composites BMEVEFAM301 3 2/0/0e New Application and Technologies of Fibres BMEVEFAM302 5 3/0/1e Basic Processes in Textile Chemical Technology BMEVEFAM401 5 Polymer Physics BMEVEFAM202 4 3/0/0e Branch-depending Economic and Human Knowledge Subject Intellectual Property (IP) Management BMEVEFAM103 2 2/0/0e Patents in Pharmaceutical Industry BMEVESZM401 2 2/0/0e Control and Manag. Meth.in the Chem. Industry BMEVEKFM303 2 2/0/0e Quality assurance of drug production BMEVESZM402 2 2/0/0e Quality Control (Quality Assurance) BMEVESAM206 2 2/0/0p

66 FACULTY OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Description of B.Sc. Subjects General Subjects

Compulsory English I. Programmed spread-sheeting: Filtering measured data, auto- matic data evaluation. BMEGT63A301 Word processing, presentations: Equation Editor; Chemical structures; Handling long documents; PowerPoint presenta- Compulsory English II. tions. Www, Html: Editing a home page. BMEGT63A302 English for Engineers Mechanical Operations in Chemical Industry BMEVEVMA1O1 BMEGT63A051 Dr János Mihályi Communication Skills - English Main tasks, parts, used materials and characteristic curves BMEGT63A061 of machines. Efficiency and load. Constraints for equilibrium of rigid bodies. Influence diagrams of simple beams. Stresses Manager Communication -English and strains at different loading up conditions in elastic simple beams and thin shell bodies. Control method of these bodies BMEGT63A081 with Mohr's theory. Fluid statics. Pipes and pipe equipments. Characteristicso f fluid-flow in pipes. Conservation of mass Intercultural Communication - English and energy. Pressure loss calculation in pipes and pipe equip- BMEGT63A091 ments. Drag force, settling and floating. Selection of fluid transport machines. Operation of centrifugal pumps and pos- Mathematics A1a - Calculus itive displacement pumps. Needful pump characteristics at BMETE90AX00 the pipe system. Characteristics of fans. Operation of blowers, compressors, injectors and vacuum pumps. Transport of See descriptions at section of Common Subjects bulked materials. Laboratory measurements. Use of r.p.m.m easuringd evices, and transmissionm easuring at machines. General Chemistry Use of pressure measuring instruments. To determine the mean flow-rate with the use of different devices. Pressure loss BMEVESAA101 measurement in pipe-line and friction factor and loss coeffr- Dr. Gábor Csonka cient determination. Measurement to determine the charac- Concepts of general chemistry. Physical states and the laws teristic curves of centrifugal fan. (5 credits) of gaseous and liquid states. Basic concepts of chemical processes. Stoichiometry. Laws of mixtures and solutions. Micro- and Macroeconomics Fundamentals of thermochemistry and electrochemistry. Chemical equilibria. Properties of electrolytes and pH. BMEGT30A001 Electrolysis, galvanic cells and batteries. Fundamental concepts of colloid systems. Laws of solid state. Types and rates Mathematics A2a - Vector Functions of chemical reactions. Laws of microparticles. Structure of BMETE90AX02 atoms and molecules. Chemical bonds. See descriptions at section of Common Subjects

General Chemistry Calculations Foundations of Mathematical Statistics BMEVESAA102 BMETE90AX14 Dr Gábor Csonka Dr Márta Lázy Chemical calculations of units, concentrations, and the laws of gases and solutions. Stoichiometry. Redox reactions. Probability and combinatorics. Variables. Density func- Thermochemistry. Chemical equilibrium. Electrochemistry. tion. Discrete and continuous distributions, applications. Poisson law. Multidimensional distribution. Stochastic General Chemistry Laboratory Practice process. Conditional distribution. Estimation. Statistical assembly. Estimation. Chi square and t distribution. Statistical BMEVESEA103 probes. (2 credits) Dr. György Zsombok Laboratory devices. Basic laboratory operations. Physics I Mechanics Crystallisation. Simple preparation of precipitates and filtration. Working with acids and bases. Distillation. Sublimation. BMETE14AX10 Measurement of density. Classical determination of molecu- Dr. Zoltán Noszticzius lar mass. Electrochemistry. Buffer solutions, indicators and Vectors.Time dependent quantities, rate of changes, aver- measurement of pH. Preparation of simple inorganic com- age rate. Mechanics: mass point, rigid body, translation, rota- pounds. tion. Reference systems, coordinate systems. Mass point kinetics. Axioms of dynamics. Mechanics of the extended Computing bodies.Linear and angular momentum. Work and energy. Rigid body, elastic body. Fluids. BMEVESAA103 Dr. György Horvai Inorganic Chemistry Processing measured data. Graphs. (Excel, Matlab): Solving sets of linear equations; Linear regression; Graphs of BMEVESAA207 functions with 2 independent variables; Optimisation, solu- Dr. László Nyulászi tion of nonlinear algebric equations; Solving ordinary differ- General characterisation of elements. Non-metal ele- ential equations; Functions evaluated with a macro; ments, metals, transition metals, and f-elements. Classi- 67 BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS fication and general characterization of compounds: Dynamical systems. Optics hydrides, halides, oxides, sulphides, sulphates, carbonates, and nitrates. Organic Chemistry II BMEVESKA303 Inorganic Chemistry Laboratory Practice Dr. Lajos Novák BMEVESEA208 Synthesis and reactions of carbonic acid derivatives, dia- Dr. Ödön Wagner zomethane, azo, diazo, diazonium and related compounds, Preparation and properties of inorganic compounds. sulfur and phosphorus compounds, unsaturated acids (e.g. Solubility of elements and inorganic compounds in acid and arachidonic acid), lipids, terpenes and the steroids, substitut- base. Characteristic reactions of cations and anions of main ed acids (halo, hydroxy, oxo, amino acids), peptides and pro- group and transition metal elements. Qualitative analysis. teines, carbohydrates, five and six membered heterocycles, Combined separation and purification procedures. nucleic acids. Some heterocyclic derivatives with biochemical activity. Stereochemistry: Emil Fischer (d/l) convention in Organic Chemistry I structure determination of ?-amino acids and sugars. Stereo controlled synthesis, prochiral centers and surfaces. Methods BMEVESKA202 for enantiomeric separation. Dr. Lajos Novák In the course of these studies the students get acquainted Analytical Chemistry with the synthesis, structure and reactions of saturated and unsaturated hydrocarbons, aromatic hydrocarbons, halogen BMEVEAAA302 compounds, alcohols, phenols, ethers, nitro compounds, Dr György Horvai, Dr. Róbert Gyurcsányi amines, aldehydes, ketones, carboxylic acids and their deriv- Fundamentals of chemical analysis: sampling and sample atives. They learn the fundamentals of organic reaction mech- preparation, separation techniques, and error calculations. anism: SR, SN1, SN2, E1, E2, E1cb, SEAr, SNAr, AdE, AdN. Evaluation of analytical data. Gravimetric methods of analy- Nomenclature of organic compounds, fundamentals of stere- sis. Titrimetric methods of analysis: precipitation, acid-base, ochemistry (Cahn-Ingold-Prelog convention, specifying E/Z complex formation, and oxidation-reduction titrations. and R/S isomers etc.) are also made familiar for the students. Theory and applications of instrumental analytical methods: potentiometry, voltammetry, conductometry, thermal analy- Chemical Technology sis, liquid and gas chromatography, flame photometry, atomic absorption spectrometry, ultraviolet, visible and infrared BMEVEKTA202 molecular spectroscopy. Dr. György Pátzay Definition, role, characteristics of chemical technologies, Physical Chemistry I industrial branches using chemical technologies, characteristics of the chemical industry, classification of chemical prod- BMEVEFKA304 ucts, inorganic chemical technologies, basic concepts of Dr. András Grofcsik, Dr. Mihály Kállay energy production, energy sources, coal, crude oil, natural Thermodynamics: Characterization of thermodynamic gas, nuclear energy, renewable energy sources. Burning tech- systems. Internal energy, the first law of thermodynamics. nology. Water treatment technologies. Hydrocarbon produc- Enthalpy, thermochemistry. Ideal and real gases. Entropy, the tion and technology. Fuels and raw materials for the chemi- second law of thermodynamics. Gibbs free energy and cal industry. Helmoltz free energy. One component phase equilibria. Laboratory practice 28 hours, 7 lessons, 4 hours each: Thermodynamics of solutions, the chemical potential. Two water treatment, ion exchange, membrane filtering, measure- component liquid-vapor and solid-liquid equilibria, phase ment of boiler efficiency, analysis of exhaust gases, hydrocar- diagrams. Distribution equilibrium. Chemical equilibrium. bon tests, flammability, viscosity, engine exhaust gas analysis, Structure: Quantum mechanics. Structure of atoms. Energy corrosion test, catalytic reformation. levels of molecules. Computational chemistry. Optical spectroscopy. Photochemistry and photobiology. Structure of English for Engineers nuclei. Nuclear magnetic resonance. Structure of solids and liquids. X ray diffraction. BMEGT63A051 See descriptions at section of Common Subjects Polymers BMEVEMGA306 Physics I Electrodynamics Dr. Alfred Menyhard, Dr. Viktória Vargha BMETE14AX04 Definitions, classes of plastics, most important properties. Dr. Ferenc Márkus Radical polymerization. Polycondensation, cross-linked poly- Electrostatics.electric voltage, electric potential. Surface mers. Models of polymer physics. Polymer solutions. Phases (2D) charge distributions. Dipole momentum. and physical states. Behaviour of solid polymers, rubber elas- Magnetostatics. Stationary fields and direct current. Kirch- ticity. Uniaxial deformation, tensile testing, necking. Fracture, hoff's laws. Direct current and its magnetic field .Alternating brittle and ductile failure. Relationship of molecular and current. Capacity and inductance. Rapidly changing electric macroscopic structure. Crystalline polymers. Melting, crystal- fields and electromagnetic waves. lization, polymorphism. Correlation between crystalline structure and properties. Structure of amorphous polymers. Physics Laboratory Polymer blends and composites. Physical states and processing modes. Machining. Application of plastics. Type and BMETE14AX11 cause of degradation. Types of additives. Plastics and the Dr. Mária Wittmann environment. Plastics based on natural resources. Biodegra- Introduction: evaluation of measurements; DC and AC cir- dable polymers. Lab practice demonstrating the most impor- cuits. Control of electric current and voltage. Resistance mea- tant processing technologies and quality control methods. surement, compensation. Alternating current. Semi- conductors. Temperature measurement. Logical circuits. 68 FACULTY OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Organic Synthesis Laboratory Practice Environmental Chemistry and Technology BMEVESKA307 BMEVEKFA403 Dr. László Poppe Dr. Gábor Bajnóczy During this course the students learn the principles of Elements of the environment, dangerous factors. The experimental organic chemistry, the ways of safe handling process of pollution: emission, transmission, imission. The and disposal of chemicals, the fast identification of the syn- aim and the instruments of environmental protection. thetized compounds and the organic chemistry literature Technical solutions. Economical instruments, fees, fines, sup- searching. The students make themselves familiar with the ports. function of the equipment used in the laboratory, the most Air polluting materials (carbonmonoxide, nitrogen oxides, important procedures to prepare, separate and purify organic sulfur oxides, ozone, hydrocarbons, photochemical oxidants, compounds (crystallization, distillation both at atmospheric particulates, dioxins, water polluting materials (materials with and reduced pressures, steam distillation, extraction, drying, high oxygen demand, detergents, mineral oils, organic com- thin layer and column chromatographies etc.). All these help pounds, inorganic compounds, chemistry of their formation, to deepen their knowledge in organic chemistry and get parameters influencing their rate of formation, their chemical acquainted with the properties of organic materials. and physical interaction with the atmosphere, hydrosphere, litosphere and biosphere. Biologycal degradation of poly- Analytical Chemistry Laboratory Practice mers. Heat pollution. Techniques of air and water pollution control. Classi- BMEVEAAA403 fication of wastes, dangerous wastes, treatment and disposal Dr. Béla Koczka, Dr. Róbert Gyurcsányi technologies. Gravimetric and titrimetric (acid-base, argentometry, com- plexometry, redoxi) determinations of different inorganic ions. Organic Chemical Technology Determination of inorganic and organic compounds using various instrumental analytical (potentiometry, conductome- BMEVESTA411 try, liquid-, gas- and thin layer chromatography, flame pho- Dr. György Keglevich, Dr. Péter Bakó tometry, atomic absorption spectrometry, fluorimetry, ultravi- The subject shows the typical fields, equipment and trans- olet/visible spectroscopy, flow injection analysis) methods. formations of the organic chemical industry. The relevant fields discussed are: C1-, C2- and C3- intermediates, as well Physical Chemistry II as aromatic substrates; detergents, washing powders and environmental considerations; pesticides, such as insecti- BMEVEFAA405 cides, fungicides and herbicides, toxicity and environment; Dr. András Grofcsik features of the pharmaceutical industry, typical syntheses and Transport processes: Thermodynamic driving forces. Laws technologies illustrated by the examples of some drugs select- of diffusion. Heat conductance. Viscosity. Reaction kinetics: ed; principles of green chemistry, environmental-friend con- Homogeneous reactions. First order and second order reac- siderations; characteristics of the plastic and rubber industry, tions. Equilibrium reactions. Consecutive and parallel reac- recycling of thermoplastics; the textile and dye industry, nat- tions. Temperature dependence of reaction rates. Reactors. ural and synthetic dyes. Kinetics of heterogeneous reactions. Electrochemistry: Equilibrium in electrolytes. Thermodynamics of galvanic Organic Chemical Technology Laboratory cells. Electrode potentials. Conductivity of electrolytes. Kinetics of electrode processes. Practice BMEVESTA412 Medicines Dr. György Marosi In the framework of the laboratory practice, the students BMEVESTA403 get acquainted with typical organic chemical transformations Dr. Ferenc Faigl (eg. oxidation, hydrogenation, esterification, Friedel-Crafts The subject gives a breaf introduction to the medicinal reaction, diazotation and coupling) carried out in a suitable chemistry and pharmacology. The fundamental pharmaco- reactors, such as stirred tank reactor, tube reactor, autoclave, logical definitions and ideas as well as a historical outline of cascade reactor, ball- and tube mill and Mettler-Toledo intel- drug discovery and design are presented. Selected examples ligent reactor. Operation of the reactors should be optimized of drug action at some common target areas demonstrate the by studying the effect of the technological parameters, such importance of the special receptor-drug interactions and the as temperature, pressure and stirring. The reaction mixtures improtance of chemical modifications of the leading mole- are analysed by up-to-date techniques. cules to produce highly selective medicines. Typical examples are also discussed for drug metabolism including several organic chemicals and solvents which are important for the Chemical Unit Operations I organic chemists. BMEVEKFA410 Dr. András Deák, Dr. Endre Rév Colloid Chemical Principles of Nanotechnology Unit Operations of Chemical Engineering. Continuity equations, mass balance, component balance, energy equa- BMEVEFAA409 tion, momentum balance, equations of motions, transport Dr. Zoltán Hórvölgyi equations, equations of state, equilibrium, chemical kinetics. Short history of colloid chemistry: from colloids to nan- Fluid mechanics, concepts of fluid behaviour, steady flow, otechnology. Classification of colloid systems. Interfaces, sur- rheology, viscosity, boundary-layer formation, friction factor. face tension. Curved surfaces, capillarity. Surface tension of Navier-Stokes, Euler and Bernoulli equations. Transportation solutions. Adsorption, adsorbents. Solution of macromole- of fluids. Hydrodynamic models, flow in pipes and channels, cules. Micelles and membranes. Biological aspects of col- pressure flow through equipment, pressure drop across loids. Dispersions, micro- and macroemulsions, foams. packed towers. Mechanical unit operations: Mixing, sedi- Particle size measurements. Colloid stability. Rheology. mentation, thickeners, filtration. Electrical and magnetic Colloids in Nanotechnology methods, centrifugal separation, fluidisation, pneumatic transport, gas cleaning, cyclones. Flow of heat, conduction, 69 BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS convection, radiation. Rate of heat transfer, heating and cool- rectification with constant reflux ratio and with constant puri- ing: viscosity correlation. Dimensional analysis. Heat transfer ty. Azeotropic and extractive distillation methods. Pressure of condensation, steady and unsteady- state heat transfer. swing distillation. Absorption. Kremser-Souders-Brown equa- Heat transfer in shell and tube heat exchangers. Evaporation, tion. Liquid extraction. Equilibrium ratio, distribution ratio, boiling point rise. Standard and multiple-effect evaporators, and phase ratio. Simple extraction. Repeated extraction. vapour compression. Perkolation. Continuous countercurrent multistage extraction. Counter-solvent extraction. Devices. Computation with Business Law constant equilibrium ratio, graphical constraction with constant phase ratio and with non-constant phase ratio. BMEGT55A001 See description at section of Common Subjects Management and Business Economics BMEGT20A001 Biochemistry for Chemical Engineers Dr. Tamás Koltai BMEVEMBA503 Basic functions of management: management accounting, Dr. András Szarka cost behaviours and break-even analysis, product mix analy- Principles of bioenergetics. Enzymes. Energy sources and sis, inventory control, forecasting, and scheduling problems. main metabolic pathways of living organisms. Carbohydrate metabolism. Lipid metabolism. Protein and amino acid Safety Technology in the Chemical Industry metabolism. Metabolism of nucleotides. Integration of metabolism. Generation and storage of metabolic energy. Citric BMEVESTA601 acid cycle. Genetic information (storage, transmission and Dr. István Csontos expression). The central dogma of molecular biology. Alcohol Occupational safety, workers' protection. Employer- and drug metabolism. The regulation of metabolic pathways. employee connections and responsibilities. Fire and explosion hazards. Emergence of brisance and explosion. Physical Chemistry Laboratory Practice Substances liable to auto-ignition and peroxide formation. Principles and practice of fire and explosion prevention in BMEVEFKA506 case of various ignition sources Transport and storage of haz- Dr. János Bódiss ardous substances. R and S phrases. Material Safety Data Measurement of temperature, pressure and flow rate. Sheet. Transport and storage of incompatible substances. One component phase equilibrium. Temperature depend- Safety engineering and proprietary approach. Insurance of ence of dissociation equilibrium constant. Calorimetry. industrial plants. Special requirements of work with high pres- Electrochemical cells, electrode kinetics. Determination of sure vessels. Definition of poisoning. Permitted exposure limit order of reaction and rate constant. Determination of diffu- (PEL), threshold limit value (TLV), maximum workplace con- sion coefficient. Measurement of viscosity. centration (MAK). Poison categories. Lethal dose, lethal concentration. Toxic substances classified by effect type. Risks of Chemical Process Control toxic substances in lab, industry and environment. Protection against toxic substances. Definition of a disaster. Noteworthy BMEVEVMA504 disasters in the chemical industry. Dr. Péter Mizsey Analysis and assessment of biological risks. Prevention of Aims of the chemical process control. Areas and methods infection - general considerations, methods. of process control, feed forward control, feed back control. Mathematical basics, dynamic behaviours. Transfer function, Quality Management frequency function. Model and modelling of chemical units and process from control point of view. Stability, its definitions BMEVEKFA615 in time, frequency, and Laplace domain. Controllers, controller algorithms, different controls and their characteriza- tions. Controller tuning. Actuators, control valves. Basic con- Chemical Unit Operations Laboratory trols: level, flow, pressure, temperature controls. Cascade controls. Control of multivariable processes. Interaction Practice among control loops. Examples and solutions for the control BMEVEKFA613 of chemical units and processes. Dr. Endre Rév, Dr. András Deák, Dr. Béla Simándi Laboratory practice with pilot-scale apparatus (evapora- Chemical Unit Operations II tors, heat exchangers, mixers, filters, gas absorption, distillation, rectification, extraction etc). BMEVEVMA512 Dr. Béla Simándi, Dr. Endre Rév Characterization and calculation of liquid-liquid and gas- liquid-liquid equilibria. Equilibrium ratio, vapor tension, Antoine equation, Raoult-Dalton equation, relative volatility, bubble-point calculations, phase distribution calculations. Use of binary phase plots and equlibrium plots, use of terna- ry phase plots. Single stage equilibrium distillation and flash. Simple distillation. Rayleigh equation, vapor consumption. Steam distillation. Continuous multistage distillation. Reflux ratio. MESH equations. CMO. Upper and lower operating lines. Q-line. Graphical determination of the theoretical number of stages. Graphical determination of the minimum number of theoretical stages. Fenske equation. Minimum reflux ratio, graphical construction. Relations between number of stages, reflux ratio, and product purity. Plates and packings. Stage efficiency, HTU, NTU, HETP. Column capacity. Batch 70 FACULTY OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Description of B.Sc. Subjects Branch Subjects

Branch of Analytical and Structural Structural Chemistry Chemistry BMEVEFKA708 Dr. Miklós Kubinyi The following topics are discussed: Principles of quantum Analytical and Structure Determination mechanics. Structure of atoms. Optical spectroscopy. Laboratory Rotation and vibration of molecules. Electron structure of BMEVEAAA604 molecules. Photo electron spectroscopy. Lasers and laser Dr. János Madarász spectroscopy. Energy states of nuclei. Nuclear magnetic resonance and electron spin resonance spectroscopy. Mass spec- The measurement of various samples by UV/VIS, infrared trometry. X-ray diffraction. (IR), mass (MS) and nuclear magnetic resonance spectroscopy, powder and single crystal diffraction, scanning electron microscopy, SEM EDS and joint analytical (GC-MS, Organic Chemistry III TG/DTA-MS, TG-IR, HPLC-MS-MS) methods. A brief summa- BMEVESKA504 ry of the above techniques. Dr. László Poppe Based on the knowledge of general organic chemistry, this Elemental Analysis subject put a major emphasis on all aspects of preparation BMEVEAAA507 and analysis of optically active compounds. By systematic classification of all major stereochemical terms, this subject Dr. János Madarász, Dr. László Bezúr adds solid stereochemical knowledge to the existing under- Classification of elementanalysis methods, performances. standing of synthetic methods. In addition, students get a Foundations of atomic spectroscopic methods. Important summary on the methods for analysis of enantiomeric com- radiation and atom sources in analytical atomic spectroscopy, position. The different types of modern stereoselective trans- the processes taking place in these sources. Emission analyti- formations including various aspects of kinetic resolutions cal methods: flame photometry, arc-, spark-, ICP-OES and and asymmetric syntheses by chemical and biotransforma- GD-OES spectrometry. Atomic absorption methods: flame tions are also covered. atomic absorption, graphite furnace atomic absorption. Mass spectrometric methods: ICP-MS, GD-MS. Design and optimisation of the analytical methods. Methods and instrumenta- Design of Experiments tion of sample preparation. BMEVEVMA606 Dr. Sándor Kemény Chemical and Biosensors Principles of mathematical statistics: distributions, usage of BMEVEAAA708 tables. Testing hypotheses, estimation theory. Basics of regression analysis: Linear regression for one independent variable, Dr. Róbert Gyurcsányi repeated and unrepeated cases, weighted regression, param- Basic concepts and principles informing the design and eter estimation, splitting the sum of squares (Fisher-Cochran use of chemical and biosensing devices and systems; Signal theorem), checking the adequacy of straight line, confidence transducers with special emphasis on electrochemical and regions. Multiple linear regression: parameter estimation, sig- optical transducers; Development of bioselective layers nificance tests. Advanced regression. Fitting nonlinear mod- (immobilization strategies, patterning and types of biological els: parameter estimation if the function may or may not be components used); Applications of chemical and biosensor- transformed into linear in parameters, effect of transformation. based instrumentation in the medical, bioprocess, and envi- Design of experiments: Principles, active and passive experi- ronmental fields. ments, optimal and optimising DOE. Selection of the objec- tive function. 2p full factorial, orthogonality and rotatability, Chromatography parameter estimation, testing significance of effects. 2p-r frac- BMEVEAAA611 tional factorial designs. Discussion of implementation of the designs (width of interval of variation, deciding on factors, Dr. Jenõ Fekete interpretation of significance tests). Box-Wilson method for Basic concepts and principles of chromatography. approaching the optimum. Simplex method. Quadratic Classification of the various methods. Instrumentation (detec- designs: 3p and central composite designs. The students solve tors, stationary phases, solvents). Practical considerations. problems during classes. Optimization of the experimental parameters to achieve the best separation. Application fields of chromatography.

Organic Structure Analysis BMEVEAAA512 Dr. Áron Szöllõsy Introduction into the theory of ultraviolet, circular dicro- ism, infrared, mass and nuclear magnetic resonance spectroscopy and single crystal X-ray diffraction. Presentation of their application for the solution of practical problems. Presentation of their joint application in the elucidation of the structure of unknown compunds.

71 BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS

Branch of Chemical and Process processes are presented and analyzed. Successful applica- Engineering tions in chemical industry and energy production are introduced. Promising avenues for research, development and innovation are identified. Novel processes which make the technologies less contaminating, less harmful to sensitive Catalysis and Hydrocarbon Processing products and have low energy consumption are summarized. Laboratory Practice These include cleaner energy production technologies, high- BMEVEKTA505 ly selective catalysts and biocatalysts for new and specific Dr. György Pátzay chemicals, clean technologies using membrane separations Catalytic reforming; Modelling of catalytic reforming; or supercritical fluids. Steam cracking of gasoline; Alkylation of toluene on zeolite; Hydrogenation of toluene; XRF determination of Pd content Computer Process Control of activated carbon supported catalysts BMEVEVMA709 Dr Péter Mizsey Hydrocarbon Processing BMEVEKTA506 Chemical Production Control Dr. György Pátzay BMEVEKTA707 Definition, role, characteristics of crude production, refin- ery technologies, including distillative separation and chemi- Dr. Béla Kelemen cal and catalytic conversions. Production of fuel and lubri- cant components. Production and use of aromatic com- Branch of Industrial Pharmaceutics pounds. Basic petrochemical technologies, including steam- cracking, acetylene production, soot production. Organic Structure Analysis Process Engineering BMEVEAAA512 BMEVEVMA605 Dr. Áron Szöllõsy Dr. Endre Rév Introduction into the theory of ultraviolet, circular dicro- Basics of characterization and modelling of chemical ism, infrared, mass and nuclear magnetic resonance spec- processes consisting of several unit operations connected troscopy and single crystal X-ray diffraction. Presentation of with material, energy, and information lines are first intro- their application for the solution of practical problems. duced. Flowsheeting techniques are discussed and practiced. Presentation of their joint application in the elucidation of the Steady state processes, equilibrium based processes, and structure of unknown compounds. practical modelling of heterogeneous phase equilibria, are mainly kept in focus but dynamics are also considered. Basic approaches, algorithms, and a commercial modelling soft- Organic Chemistry III ware are presented, their application is practised. A short BMEVESKA504 overview to process design / process synthesis is also provid- Dr. László Poppe ed. Based on the knowledge of general organic chemistry, this subject put a major emphasis on all aspects of preparation Design of Experiments and analysis of optically active compounds. By systematic classification of all major stereochemical terms, this subject BMEVEVMA606 adds solid stereochemical knowledge to the existing under- Dr. Sándor Kemény standing of synthetic methods. In addition, students get a Principles of mathematical statistics: distributions, usage of summary on the methods for analysis of enantiomeric com- tables. Testing hypotheses, estimation theory. Basics of regres- position. The different types of modern stereoselective trans- sion analysis: Linear regression for one independent variable, formations including various aspects of kinetic resolutions repeated and unrepeated cases, weighted regression, param- and asymmetric syntheses by chemical and biotransforma- eter estimation, splitting the sum of squares (Fisher-Cochran tions are also covered. theorem), checking the adequacy of straight line, confidence regions. Multiple linear regression: parameter estimation, significance tests. Advanced regression. Fitting nonlinear mod- Organic Chemistry Laboratory Practice II els: parameter estimation if the function may or may not be BMEVESKA605 transformed into linear in parameters, effect of transformation. Dr. László Poppe Design of experiments: Principles, active and passive experi- Preparation of complex organic compounds in multistep ments, optimal and optimising DOE. Selection of the objec- processes involving chemical and chemoenzymatic methods. tive function. 2p full factorial, orthogonality and rotatability, Separation of mixtures of organic compounds using thin lay- parameter estimation, testing significance of effects. 2p-r frac- ers, and various preparative chromatographic methods. tional factorial designs. Discussion of implementation of the Applications of spectroscopic methods in qualitative, and designs (width of interval of variation, deciding on factors, GC, HPLC in quantitative organic analysis. Using journals, interpretation of significance tests). Box-Wilson method for reference works, advanced textbooks and electronic databas- approaching the optimum. Simplex method. Quadratic es for searching useful synthetic methods. designs: 3p and central composite designs. The students solve problems during classes.

Environmental Benign Chemical Process BMEVEVMA607 Dr Béla Simándi

Environmentally benign unit operations and chemical 72 FACULTY OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Industrial Planning Practice II edge about all steps of production of pharmaceutical products. The themes of the subject are as follows: BMEVESTA702 Basic terms of biomaterials and excipients, biological Dr. Alajos Grün transport mechanisms, toxicological aspects, in pharmaceuti- Integrated application of basic, engineering, and econom- cal technology, classification of pharmaceutical products, ic studies. Summarizes the practical process and equipment incoherent, and coherent products, micro and macro cap- design methodology; covers decision making and plant prof- sules for controlling the drug release, analysis of qualitative, itability evaluation. Student groups work on a department quantitative and structural analyses transdermal, ophtalmo- specified practical industrial problem. They chose the neces- logical and aerosol systems, aseptic production, packaging of sary equipment, plan their size, make flow-sheets and calcu- pharmaceuticals. late the time requirement of processes. During their work they have to adopt up to date requirements of the safety, GNP, Unit Processes of Organic Chemistry environmental protection and green chemistry. Their reports are validated by an industrial expert. BMEVESTA508 Dr. György Keglevich Pharmaceutical technology The subject gives an overview on the most important chemical transformations relevant to the pharmaceutical-, BMEVESTA704 pesticide- and fine chemical industry. The following basic Dr. Zoltán Hell processes are discussed systematically: alkylation and acyla- This subject gives an overview on the characteristic meth- tion including the Friedel-Crafts reactions, halogenations, sul- ods for the industrial synthesis of pharmalogically active sub- fonations, nitrations, diazotation and azo-coupling, oxida- stances based on known technologies of Hungarian and other tions, hydrogenations, CO-reactions and others. The stress is producers. The relevant fields discussed are: choice of the laid on the substrates, reagents, catalysts and optimum condi- synthesis strategy, development and permanent updating of tions, as well as on industrial examples and environmental- the industrial technology from different aspects such as the friend solutions. protection of the environment, the assurance of the quality, the safety, the thrift and the protection of the copyright. Choice of the appropriate equipment, technologies for sepa- Branch of Material Science ration of pharmacologically active substances and their intermediates from natural raw materials (plants, animals). Aspects of the diminution of the waste materials produced, waste Physical Chemistry of Surfaces treatment. BMEVEFKA603 Dr. Krisztina László Unit Processes in Industrial Drug Synthesis Fundamentals of solid/fluid interfaces. The qualitative Laboratory Practice description of the surface layer, the concept of surface excess. BMEVESTA705 Thermodynamics of the interfaces, surface tension and inter- Dr. Ferenc Faigl action potential. Interactions at solid/gas and solid/liquid In the framework of the practice typical industrial level interfaces. Adsorption isotherms, their interpretation (Lang- synthetic technologies and processes are presented for the muir, BET, Dubinin-Radushkevich and DFT models). Expe- students. The theoretical background of the unit processes rimental methods, including calorimetry. Particle size analy- applied in the presented technologies has been discussed in sis. Applied surface science: the role of interfaces in material the lectures of "Unit Processes in Drug Synthesis" and high- science, environmental and industrial processes. Hetero- lighted again during the practices. genous catalysis, Pressure/Temperature Swing Adsorption

Unit Processes in Industrial Drug Synthesis Functional and Intelligent Materials BMEVESTA606 BMEVEFKA707 Dr. Ferenc Faigl Dr. Zoltán Hórvölgyi The subject deals with the typical chemical transforma- The scope of Functional and Smart Materials relates to tions, isomer separation techniques and scale up processes of materials, both synthetic and natural. On the basis of their the pharmaceutical and fine chemical industry. Among the response to different stimuli, major distinction will be made unit processes the special N-, O- and C-alkylations, C-C bond between the structural- and functional materials. Special forming reactions (Claisen-, Dieckman-, Knoevanagel- és emphasis will be devoted to the structure and properties of Darzens-condensation, Vilsmeyer-formylation, synthesis and biomaterials. The basic properties of the synthetic functional- reactions of polar organometallics), and selective reductions , multifunctional and smart materials will also be discussed, with inorganic and organic hydrides are discussed. The theo- including electrostrictive-, magnetostrictive-, piezoelectric ry and methods for separation and enrichment optical iso- hard materials, as well as electrorheological- and magne- mers, as well as the rules of application dry technologies are torheological liquids, responsive gels, and special polymers discussed and illustrated by industrial examples. for biomedical and pharmaceutical applications

Technology of Pharmaceutical Materials Chemistry and Technology of Macromolecules BMEVESTA607 BMEVEMGA504 Dr. György Marosi Dr. Emilia Csiszár The aim of the lectures is to introduce the students into the Types of polyreactions: polymerization, polycondensation, technology of pharmaceutical products including the excipi- polyaddition and other new polymerization reactions. ents and drug delivery systems. The relevant structural and Classification of chain polymerization reactions: radical, pharmaco-kinetical relationships, production, analytical and anionic, cationic and stereospecific polymerization. Theory application methods are also covered. Completing the sub- of free radical polymerization. Elementary reactions of radical ject the students must be acquainted with the theoretical basis polymerization. Types of initiators and the characteristics of of pharmaceutical formulation and must have basic knowl- their decomposition kinetics. Mechanism of chain propaga- 73 BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS tion, termination and chain transfer reactions. Inhibition of Metals, Ceramics and their Associated Systems radical polymerization. Theory of copolymerization. Characteristics of anionic and cationic polymerization. Living BMEVEMGA613 anionic and cationic polymerization and their significance in Dr. Béla Pukánszky preparative polymer chemistry. Stereospecific polymeriza- Introduction tion. Mechanism and kinetics of polycondensation and Metals, alloys and associated metallic materials polyaddition reactions. Chemical reactions of polymers. Basics of metallurgy I. Types of cross-linking reactions. Degradation and stabiliza- Basics of metallurgy II. tion of polymers. Advanced technology Corrosion protection of metallic structural materials Experimental Methods in Materials Science Short history of the ceramic industry Main types and applications of advanced ceramics BMETE12AX12 Production of advances ceramics Dr. Ferenc Réti Ceramic composites Bonding and structure in solids (crystal geometry, glass- like materials). Properties of the electron structure in solids, formation of the bands from atomic levels in metals and iso- Branch of Polymer Technology lators. Density of states and density of optical states. Vibrations in solids. Differences between the crystalline and amorphous materials. Crystal defects, surfaces and their Experimental Methods in Materials Science effects. Methods using the excitation of the electronic struc- BMETE12AX12 ture (XPS, UPS, AES, SIMS, absorption spectroscopy of the Dr. Ferenc Réti solids. Methods using the excitation of the lattice. Bonding and structure in solids (crystal geometry, glass-like Thermoanalytique, IR and Raman spectroscopy. Methods for materials). Properties of the electron structure in solids, forma- studying the structure (XRD, SEM + EDX, SPM ((EC)-STM, tion of the bands from atomic levels in metals and isolators. (EC)-AFM, nanoidentator)). Density of states and density of optical states. Vibrations in solids. Differences between the crystalline and amorphous Methods in Material Science Laboratory Practice materials. Crystal defects, surfaces and their effects. Methods using the excitation of the electronic structure BMEVEMGA502 (XPS, UPS, AES, SIMS, absorption spectroscopy of the Dr. Béla Pukánszky solids). Methods using the excitation of the lattice. Methods using the excitation of the electronic structure Thermoanalytique, IR and Raman spectroscopy. Methods for (XPS, UPS, AES, SIMS, absorption spectroscopy of the solids). studying the structure (XRD, SEM + EDX, SPM ((EC)-STM, Methods using the excitation of the lattice (thermal analysis, (EC)-AFM, nanoidentator)). IR and Raman spectroscopy). Methods for studying the structure (XRD, SEM + EDX, SPM ((EC)-STM, (EC)-AFM, nanoiden- Chemistry and Technology of Macromolecules tator)) BMEVEMGA504 Material Science Laboratory Practice Dr. Emilia Csiszár Types of polyreactions: polymerization, polycondensation, BMEVEMGA603 polyaddition and other new polymerization reactions. Dr. Emilia Csiszár Classification of chain polymerization reactions: radical, Introduction anionic, cationic and stereospecific polymerization. Theory Characterization of plastics of free radical polymerization. Elementary reactions of radical Fracture mechanics polymerization. Types of initiators and the characteristics of Determination of mechanical properties of plastics (tensile their decomposition kinetics. Mechanism of chain propaga- and bending tests) tion, termination and chain transfer reactions. Inhibition of Thermal characterization of polymers radical polymerization. Theory of copolymerization. Fibre reinforced polymers Characteristics of anionic and cationic polymerization. Living Characterization of fibrous materials anionic and cationic polymerization and their significance in Investigations of layers preparative polymer chemistry. Stereospecific polymeriza- Electrochemical investigation of galvancorrosion tion. Mechanism and kinetics of polycondensation and Investigation of diffusion kinetics polyaddition reactions. Chemical reactions of polymers. Types of cross-linking reactions. Degradation and stabiliza- Polymer Physics tion of polymers. BMEVEMGA511 Dr. Béla Pukánszky Machines and Tools for Polymer Processing Introduction. Terms and definitions: monomer, polymer, BMEVEMGA705 homo- and copolymer. Structure of the polymer, segments, Péter Müller entanglement. Supermolecular structure, amorphous and Introduction. Extrusion: constitution of an extruder, oper- crystalline materials. The individual chain. Shape, conforma- ation of an extruder, extruder screws, choosing the proper tion, conformation distribution. The freely joined chain screw for a polymer. Characteristics of an extruder screw and model. Interactions, solutions, determination of molecular its optimal operational point, film blowing, sheet extrusion. weight. Phases and physical states, termomechanics. Rubber Wire coating, profile extrusion, filament extrusion, coextru- elastic state, thermodynamics. Rubber elastic state, kinetics. sion. Injection molding: Tool designing, simulation software. Flow, rheology. Measurement of viscosity. Glassy state, frac- Particular injection molding techniques: Gas and water injec- ture, polarization optics. Crystalline polymers, structure. tion, Injection molding on films, Injection molding on textiles Crystallization kinetics, melting. Structure-property correla- Compression moulding machines and tools Thermoforming tions, plasticization. machines and tools 74 FACULTY OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Branch of Textile Technology Polymer Processing BMEVEMGA608 Dr. Béla Pukánszky Experimental Methods in Material Science Introduction BMETE12AX12 Rheology - flow, viscosity Dr. Ferenc Réti The measurement of the characteristics of the melt (viscosity, elastic properties) Bonding and structure in solids (crystal geometry, glass- Heat transfer processes like materials). Properties of the electron structure in solids, Extrusion - equipment, basic processes formation of the bands from atomic levels in metals and iso- Extrusion - dies, products lators. Density of states and density of optical states. Injection molding - equipment, the mould filling process Vibrations in solids. Differences between the crystalline and Injection molding - the structure of injection molded prod- amorphous materials. Crystal defects, surfaces and their ucts; molds effects. Methods using the excitation of the electronic struc- Extrusion and injection blow molding, rotational molding ture Calendering (XPS, UPS, AES, SIMS, absorption spectroscopy of the Welding and other operations solids. Methods using the excitation of the lattice. Processing of thermoset resins Thermoanalytique, IR and Raman spectroscopy. Methods for Other processing technologies studying the structure (XRD, SEM + EDX, SPM ((EC)-STM, (EC)-AFM, nanoidentator)). Polymer Physics Laboratory Practice BMEVEMGA509 Chemistry and Technology of Macromolecules Dr. Béla Pukánszky BMEVEMGA504 Introduction Dr. Emilia Csiszár Preparation and reactions of polymers Types of polyreactions: polymerization, polycondensation, Qualitative analysis of polymers polyaddition and other new polymerization reactions. Rheology Classification of chain polymerization reactions: radical, IR spectroscopy anionic, cationic and stereospecific polymerization. Theory Thermal analysis I of free radical polymerization. Elementary reactions of radical Thermal analysis II polymerization. Types of initiators and the characteristics of Impact testing their decomposition kinetics. Mechanism of chain propaga- Mechanical properties of polymers tion, termination and chain transfer reactions. Inhibition of Fibre-reinforced composites radical polymerization. Theory of copolymerization. Polymer foams Characteristics of anionic and cationic polymerization. Living Welding of polymers anionic and cationic polymerization and their significance in preparative polymer chemistry. Stereospecific polymeriza- Polymer Additives tion. Mechanism and kinetics of polycondensation and polyaddition reactions. Chemical reactions of polymers. BMEVEMGA610 Types of cross-linking reactions. Degradation and stabiliza- Dr. Béla Pukánszky tion of polymers. Introduction. Changes taking place during the processing and application of plastics, chemical reactions, degradation, Fibre Forming Polymers ageing. Degradation and stabilization. Light stabilization. PVC degradation and stabilization. Degradation and stabi- BMEVEMGA512 lization of other polymers. Lubricants. Fillers, surfactants, Dr. Judit Borsa coupling agents. Polymer additives (impact modifiers, pro- Phyisical and chemical properties of fibre forming macro- cessing aids). The purpose of their application, mechanism. molecules, groups of fibre types, properties of fibres and their Flame retardants. Blowing agents, colorants. Other additives. role in the practice, natural fibres (cellulosic fibres, wool, silk), Further aspects of the application of additives. Additive pack- natural polymer based man made fibres (regenerated cellu- ages, interaction of additives - PVC, polyolefins lose fibres), synthetic fibres (polyamides, polyesters, poly- acrylnitrils), technologies of fibre manufacturing, special Polymer Physics fibres and applications. BMEVEMGA511 Dr. Béla Pukánszky Chemistry of Dyes and Surfactants Introduction. Terms and definitions: monomer, polymer, BMEVEMGA514 homo- and copolymer. Structure of the polymer, segments, Dr. András Víg entanglement. Supermolecular structure, amorphous and Colouristic knowledge will be presented based upon the crystalline materials. correlation between the colour and structure of dyes. The individual chain. Shape, conformation, conformation Systems, production, chemical and technological characteris- distribution. The freely joined chain model. Interactions, solu- tics and application of dyes and surfactants on the field of tions, determination of molecular weight. Phases and physi- macromolecular systems as specially of fibrous ones will be cal states, termomechanics. Rubber elastic state, thermody- presented. Methods of fastness property investigations of dyed namics. Rubber elastic state, kinetics. Flow, rheology. systems (e.g. light fastness, rubbing fastness, wash fastness) are Measurement of viscosity. Glassy state, fracture, polarization included. Optimal water and energy consumption as well as optics. Crystalline polymers, structure. Crystallization kinet- the reduction of environmental pollution will also be dis- ics, melting. Structure-property correlations, plasticization cussed.

75 BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS

Colorimetry, Color Measurement concepts of knitting, basics of the study of fabric construction in case of weft and warp knitted fabrics, types of knitting BMEVEMGA515 machines and their construction. Braiding and operation of Dr. Sándor Csányi braiding machines. Preparation methods of non-woven tex- Colorimetry, optics, Areas of application. Characterization tiles. and systematization of colours. Hue, lightness, saturation. Munsell system. Colour expression. Light-sources, characterization of illuminants, spectral distribution of energy, spectral distribution of the light Quantifying Colour, CIE colour system CIE 1931 and CIE 1994 systems Uniform colour spaces XYZ tristimulus values, colour coordinates Colour difference values: explanation and calculation Modern colorimeters Colour-matching functions, Kubelka-Munk equation, relations of reflection and dye concentration. Application of colour measurement for quality assurance Measurement of whiteness, whiteness indices. Fluorescent or optical brighten- ers.

Textile Chemistry Laboratory Practice BMEVEMGA716 Dr. Judit Borsa Easy care (crease resistant) finishing, testing of finished textiles, soiling and soil release ability of textiles, characterization of textile-water systems; quality tests of textiles, visit to a professional textile laboratory

Chemical Technology of Textiles I BMEVEMGA617 Dr. Emilia Csiszár Lectures: - Preparatory processes: desizing, scouring, bleaching, car- bonizing. - Mercerization and liquid ammonia treatment. - Dyeing processes: fundamentals and methods. - Textile printing Practices: - Identification of textile materials. - Preparatory processes: desizing, scouring and bleaching. - Dyeing of cellulosic fibres. - Dyeing of wool. - Dyeing of synthetic-polymer fibres. - Textile printing

Chemical Technology of Textiles II BMEVEMGA718 Dr. Emilia Csiszár Introduction Specific functional finishes (Crease resistance, Dimensional stability, Flame retardancy, Antimicrobial finishes, Shrinkproofing, Resistance to abrasion and pilling, Soil- release and repellent finishes) Laundering Coatings Environmental impact of textile wet processes Quality insurance of textiles

Textile Mechanical Technology BMEVEMGA619 Dr. Marianna Halász The system of textile products and technologies, properties of textiles. Textile raw materials and their primary processing. Preparation of spinning (decoupling, cleaning, mixing) and spinning (carding, lengthening, combing, pre- and postspin- ning) technologies. Twisted yarn, twisting technology. Preparation of weaving and knitting (winding, warping, siz- ing, threading). The principle and basic concepts of the weaving, basics of the study of fabric construction, types of weaving machines and their construction. The principle and basic 76 FACULTY OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Description of M.Sc. Subjects General Subjects

Differential Equations methods to combinatorial chemistry. This subject from one hand expands and develops further the knowledge and way of thinking of students in the area of organic chemistry and Dr. János Tóth from the other hand establishes the organic chemistry basics Explicit first order ordinary differential equartions and their in their studies of industrial, process-engineering, analytical, solution. Existence, uniqueness, continuous dependence on material, pharmaceutical, plastic, polymer, fiber and synthet- data. Estimating the error of the model and that of the meas- ic chemistries and also of stereochemistry.The theory and urements. The simplest types. Linear systems. Higher order application of the most important types of reactions: nucle- equations. Laplace transform and its applications. Elements of ophilic and electrophilic substitutions, addition to multiple the qualitative theory. Elements of partial differntial equations. carbon-carbon bonds, polymerization, elimination, nucleophilic addition and addition-elimination at carbonyl groups, Complex and Organometallic Chemistry nucleophilic addition and addition-elimination at conjugated systems, polycondensation, ring closing and ring opening BMEVESAM101 reactions, processes accompanied by rearrangements. Simple Dr. Ilona Kovács reactions and polimerizations taking place by radical mecha- History of organometallic chemistry. Definitions. Grouping nism. Static stereochemistry and dynamic stereochemistry. of organometallic compounds. General properties of Basics of planning synthesis; kinetical, molecule structural organometallic compounds. Synthesis of organometallic and stereochemical aspects in planning synthesis. Planning of compounds. Characteristic reactions. Homogen catalysis. synthesis: retrosynthetic analysis. Synthetic strategies: linear Synthesis, structure and characteristic reactions of Li- and Mg- and convergent syntheses, synthons, inverse synthons, syn- organic compounds (substitution and addition reactions, thetic equivalents, stereochemical questions. Using of hetero- metalation and transmetalation, catalytic reactions). Synthe- cycles and natural products (sugars, amino acids, alkaloids sis, structure and characteristic reactions of Al-organic com- and their synthetic analogues) in organic syntheses. Bio- and pounds (polymer catalyst, Ziegler-Natta catalyst, synthesis of chemo-catalysis: regio- and stereoselectivity. Applying of a-olefins and a-alcohols, olefin dimerization, preparation of enantioselective synthetic methods in building up of complex organometallic compounds, preparation of high purity inor- natural products containing more than one stereocenters. ganic materials). Sn-organic compounds: synthesis, structure, Special synthetic technics. Chemical syntheses using solid and characteristic reactions (hydrostannation, hydrostannoly- supports. The basics of combinatorial chemistry. The theory sis, radical reactions, organostannylenes, redistribution reac- of molecular recognition and its use in analytical and separations). Application as polymer catalyst, stabilizer, curing tion technics. agent, and pharmaceutical. Ti-organic compounds: synthesis and characteristic reactions (substitution and insertion reac- Analytical Chemistry tions of alkines, reactions of aldehydes and ketones, reductiv coupling and elimination with Ti-organic compounds, poly- BMEVESAM102 mer catalysts). Cr-organic compounds: synthesis, characteris- Dr. György Horvai tic reactions, substitution reactions, reactions on the organic ligand, rections of carben complexes. Fe-organic com- Materials science: traditional structural pounds: synthesis, characteristic reactions, Friedel-Crafts acy- lation, Mannich reaction, metalation, cyclization, polymer- materials and polymers ization. Co-organic compounds: synthesis, characteristic BMEVEFAM101 reactions, cyclization of acetylenes and olefins, Pauson- Dr. Béla Pukánszky Khand reaction, carbonylations. Rh-organic compounds: syn- 1. Definition and significance of materials science. thesis, characteristic reactions, hydrogenations, hydrometala- 2. Metals and metal matrix composites. tions, decarbonylations, carbonylations, hydroformylations, 3. Traditional and advanced engineering ceramics: cyclizations. Ni-organic compounds: sysnthesis, characteris- production, properties, application. tic reactions, substitution reactions, carbonylation, oligomer- 4. Ceramic layered structures. Ceramic-ceramic composites. ization of unsaturated hydrocarbons, catalytic reactions, cou- 5. Ceramic-metal combinations. pling reactions with organic halides. Pd-organic compounds: 6. Polymers as structural materials. synthesis, characteristic reactions, insertions, cyclic dimeriza- 7. Polymers, fibers, composites. tions, oxidative reactions with Pd(II) catalysts, Wacker 8. Nano materials. process, reactions with Pd(0) catalysts, coupling reactions, 9. Natural polymers. Heck arylation, cyclization and carbonylation, cascade reac- 10. Structural materials from wood. tions. Cu- and Zn-organic compounds: sysnthesis, character- 11. Visits at plants and institutes (TVK, MTA MFA). istic reactions (substitution, addition and transmetalation). Chemical process design and control Organic Chemistry BMEVEKFM101 BMEVESZM101 Dr. Péter Mizsey, Katalin Koczka Dr. Péter Huszthy The basics of process design, synthesis. Heuristic and algo- In the frame of this subject the teaching of basic knowl- rithmic approaches. Environmental considerations. edge in modern organic chemistry is carried out at an Flowsheeting. Chemical reactors and their modelling. advanced level. The aim of the subject is to make acquainted Modelling of separators. Utilities, energy integration, heat the M.Sc students with the theory, the molecular structures, exchanger network. Exergy and exergy analysis. Combined the stereochemistry, the kinetics and the synthetic strategies process design strategy. Batch process scheduling and design. applicable in organic chemical reactions taking place in idus- Life cycle analysis and assessment. Control of SISO and trial sytheses, in plastic industry, in biochemical processes MIMO systems. Basic control solutions, flow control, level and in the environment. The subject also deals with the the- control. pressure control, temperature control. Control of dif- ory of planning syntheses which extend from stereoselective ferent processes. 77 BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS

Economic Analysis of Technological Processes Substantial time derivative. Density, specific quantity. Local and substantial balance equations. State equations, constitu- BMEGT30MS07 tive equations. Conservation laws. Balance equations of ener- Dr. Dietmar Meyer gy, momentum, electric charge, mass, entropy, chemical After a short introduction it will be shown how basic cate- components. Chemical reactions. Balance equation for the gories could be described using empiric analysis. This will be inner energy: Fourier's heat conduction. Cross effects. followed by the detailed investigation of the special relation- Thermodynamic driving force of the membrane-transport. ship between technology and costs, again based on empirics. Convective Nernst-Planck equations in simplified forms. The next block contains questions dealing with the econom- Chemical dynamical systems. Phase field, state vector, trajec- ic consequences of technological decisions, e. g. exhausting tory. Nonlinear dynamics and nonlinear chemistry. of natural resources, transport problem, environmental deci- Conservative and border-line cycles. Dissipative structures. sions, chosing production places, etc. Finally, problems of Chemical waves and Turing-machinery. dynamics will be investigated (control of production process- Further detailed information can be found on the depart- es, economic and technological development, etc.) ment's home page.

Project Work I Physical Chemistry and Structural Chemistry BMEVExxM100 BMEVEFAM201 Dr. Miklós Kubinyi, Dr. András Grofcsik The concept and characterization of phenomenological Design of Experiments and statistical thermodynamically systems. The laws of thermodynamics. The transformed functions of internal energy BMEVEKFM203 and the chemical potential. Thermodynamics of solutions. Dr. Sándor Kemény, Dr. András Deák Partial molar quantities. Ideal and real solutions. Statistical intervals. Confidence, tolerance and prediction Thermodynamics of phase equilibrium. Homogeneous and intervals, their use and interpretation. Error propagation heterogeneous chemical equilibrium. Equilibria in elec- (measurement uncertainty) analysis. Study of error sources of trolytes. Activities and standard states. The Debye-Hückel analytical measurements according to the EURACHEM theory. Phenomenological and statistical interpretation of the Guide. Regression analysis. Parameter estimation using least rate of reaction. Molecularity and order of reaction. squares for fitting a straight line. Assumptions and checking Homogeneous and heterogeneous catalysis, autocatalysis, their validity, adequacy of the function fitted, plotting the kinetics of enzyme reactions. Collision theory activated com- residuals. Methods applied when the variance is not constant plex theory. Photochemical reactions. Kinetics of reactions in (weighted least squares and maximum likelihood). The cali- solutions. Characterization of transport processes. Global and bration problem:confidence interval for the unknown value local balance equations. Thermodynamic driving forces. of the independent variable. Multiple linear regression. Thermodynamic driving forces. The laws of diffusion (Fick's Nonlinear regression. Analysis of variance: One-way first and second law). Laws of unidirectional, radial and cylin- ANOVA, multiple comparisons (contrasts). Assumptions and drical diffusion. Microscopic theory of diffusion. Fourier's checking their validity. Cross-classification. Box-Cox transfor- laws of heat conduction. Viscosity of liquids and gases. mation. Advanced ANOVA: random factors, nested design, Viscous flow as transport of momentum. Temperature mixed model, random block. Design of factorial experiments dependence of viscosity. Newtonian and non-Newtonian liq- Two-level full and fractional designs, Experimental optimisa- uids. Conductance of electrolytes. Conductivity and molar tion using gradient and simplex method. Quadratic designs: conductivity. Electrochemical potential. Thermodynamics of 3k, Box-Behnken and central composite designs. Statistical electrochemical cells. Nernst equation. Types of electrodes. methods for method validation Repeatability and repro- Electrode potentials. Electrode kinetics. Polarization. Laws of ducibility, robustness, linearity. The seminars contain discus- electrode kinetics. Physical chemistry of biological systems. sion of case studies and solving simpler exercises, students are The following fields of structural chemistry are discussed: requested to solve problems of medium complexity alone Infrared and Raman spectroscopy. Infrared microscope. using statistical software (Statistica). Electronic spectroscopy: absorption, fluorescence and CD spectroscopy. Study of fast processes with spectroscopic Modern Physics for Chemical Engineers methods: flash photolysis, time resolved fluorescence. Nuclear magnetic resonance. NMR spectroscopy of solid and BMETE14MX00 dissolved samples. Electron spin resonance. Spin labeling. Dr. Zoltán Noszticzius Mass spectrometry. New ionization techniques: electro spray, Elastic waves. transversal and longitudinal wave. MALDI. Structure of condensed phases. Single crystal diffrac- Interference. Standing waves. Electromagnetic waves. tion, liquid diffraction. Electromagnetic field in cavity. Dipole radiation. Polarization. Complex permittivity. Absorption. Diffraction on lattice, dif- Technologies in Organic Chemical Industry fraction on slit, resolving power, Fresnel-zones, zone lens. Geometric optics as a limit of wave optics. Special relativity. BMEVESZM201 Ether-hypothesis, Michelson-experiment, principle of special Dr. György Keglevich relativity, Lorentz-transformation. Relativistic dynamics. Rest Requirements for the startting materials, solvents, products energy, total energy. Quantum mechanics. Experimental and reactions; survey of the organic chemical industry via antecedents. Hamilton's principle, Lagrange-Hamilton-for- green glasses: dangers, problems and challanges; environ- malism, canonical equations, phase field. Operators, eigen mental friendly accomplishments in the tenzide-, pesticide- values, eigen functions. Heisenberg's commutation rules. fine chemical- and pharmaceutical industry; selection of the Schrödinger's equation. Harmonic oscillator, potential valley, appropiate solvent, up-to-date solvents, solvent-free tech- H-atom. Spin. Time dependent Schrödinger's equation. nologies; microwave synthesis as an efficient and selective Physical meaning of the state function. Heisenberg's uncer- method, industrial perspectives; transition metal complexes tainty relations. Tunnel effect. Matter wave, electron micro- incorporating P-ligands, their use as catalysts, enantioselec- scope. Electric conductivity of the solid states. Super fluidity. tive transformations; solid base and solid acid catalysts, appli- Bose-condensation. Compounds of the atomic nucleus. cation of natural and artificial clays; optimization of reactions; Foundations of transport processes. Field equations. recycling of solvents, utilization of by-products, treatment of 78 FACULTY OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY wastes; development, improvement and change of technolo- methods) gies, examples from the pharmaceutical and fine chemical 8. Biotechnological waste water treatments:removal of industry. organic materials, removal of phosphorus and nitrogen. The laboratory practice includes comparison of traditional and up-to-date technologies, the accomplishment of reac- Computational Chemistry tions in intelligent reactor, monitoring reactions by in situ. BMEVESAM301 Fourier transform IR, realization of reactions in a microwave Dr. Tamás Veszprémi reactor, optimization of heterogeneous catalytic reactions, application of the ball and tube mill, regulation by the con- A./ Lecture trolled addition of the reactants, visit to pharmaceutical facto- 1./ Basic principles of quantum mechanics: The axioms, ries to get known up-to-date technologies. the hydrogen atom, the Born-Oppenheimer approximation, the independent particle model, and the MO theory. Technology Management Hyerarchy of the theoretical models: Molecular mechanics, semiempirical, Hartree-Fock and post HF methods. Oniom BMEGT20M014 and QM-MM methods. Density functional methods. The con- Dr. Béla Pataki cept of the electron density. The basic concepts of technology management. Life cycle 2./ Application possibilities. Energy and electronic struc- theories: product, technology and factory life cycles. New ture of atoms and molecules. Computation of measures relat- technologies and the organization. Managing new product ed to physico-chemical or chemical concepts. Molecular development and product innovation. Implementing new geometry, conformation, conformational space. Modeling manufacturing technologies. Auditing technological change chemical reactions, thermodynamics and transition struc- and innovation. IT management. The basics of the strategic tures. Large systems, solutions and crystal structures. management of technology: principles, tasks, typical mis- Molecular dynamics. takes. Technology portfolio analysis. Technology roadmap- B./ Practice and problem solving ping. Managing core competencies. 1./ Molecular geometry. Building of molecuéar structures by program packages. Geometry optimization by molecular Environmentally Benign and Catalytic mechanics (Isis-draw, Hyperchem and Spartan packages.) 2./ Energy-hypersurface and conformational problems Processes (Spartan). BMEVEKMF204 3./ Ab initio computations. Basis sets. Molecular Orbitals. Dr Béla Simándi Electron density maps. (Spartan package). National and international activities with respect to envi- 4./ Computation of molecular and thermodynamic proper- ronmental programs. "Clean" technologies. EU directives, ten- ties (individual molecules, chemical processes in the gas dencies, regulations. Clean air projects, activities, processes. phase, solutions. The use of the Gaussian package. Classification of air pollutants, intervention places, exhaust reduction. Water quality control, physico-chemical treatment Social and Visual Communication of waste waters, WAO, stripping with air or steam. Clean BMEGT43MS07 technologies, supercritical solvents and processes. Membrane Dr. Zsolt Bátori processes, case studies. Catalytic processes, working mode of 1. Communication theoretical framework catalysts, kinetics, catalyst preparation, testing, modification, 2. Image and perception catalyst poisons, catalytic reactors, economics of catalytic 3. Image, society and culture processes. Catalytic processes in environmental technologies, 4. The role of pictorial representation in social communi- automotive catalysis, fuel-cells, hydrogen and methanol cation economy. At the practices the students get individual tasks, 5. The role of photographic representation in social com- get acquainted with the chosen topic, carry out measure- munication ments, evaluate them and finally report about their results in 6. Communicating in space and with space: the role of written and oral form. using space in the course of social communication 7. Visual environment and meaning 8. The role of design in social communication Project Work II 9. Images and objects as artworks in social communica- BMEVExxM200 tion Biology, Biotechnology BMEVEMBM301 Dr. Andrea Jobbágy 1. Introduction, special features of biotech: de novo fermentations and biotransformations. 2. Cell biology summary: cell structure and function 3. Microbiology and physiology survey: kinds of industrial microorganisms, their biochemistry: aerobes és anaerobes, basic microbial metabolic paths. 4. Introduction to enzyme engineering. 5. Techniques and unit operations applied in bioindustries: cultivation methods of microorganisms, culture media, steril- ization, bioreactors: mass transfer. 6. Special methods of product isolation and purification: cell homogenization, affin (biocpecific) methods. 7. Some examples in white and green biotechnology: ethanol, citric acid, lactic acid fermentations, etc., biotransformations (semisynthetic antibiotics, enzymatic resolution 79 BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS

Description of M.Sc. Branch Subjects

Branch of Analytical and Structural Modern Separation Techniques Chemistry BMEVESAM106 Dr. Jenõ Fekete Analytical Chemistry III 1. Coupling gas chromatograph to mass spectrometer (GC- MS). BMEVESAM201 2. Using of high resolution GC coupled with low resolu- Dr. György Horvai tion MS (LRMS) in environmental, food and biological sam- The lectures present the most up-to-date analytical meth- ple analysis. ods ont he basis of recent literature. 3. Principles of high resolution MS (HRMS) and coupling The laboratory exercises consist of three units: the first pro- to high resolution GC (HRGC). vides experience in making precise analytical measurements, 4. Selectivity and sensitivity of HRGC-LRMS and HRGC- the second makes the students acquainted with several sur- HRMS. face analysis methods like XRD, ESCA, SIMS, AFM, EDX, 4. Application of HRGC-HRMS in different fields SEM), the third introduces into the solution of a complex ana- 5. SFC-MS and CE-MS coupling advantages and draw- lytical problem. backs. 6. HPLC-MS coupling, principles and application areas. Sample preparation and sampling 7. Modern samples preparation methods for determination of trace and ultratrace organic compounds in different matrices. BMEVESAM204 Practical work: Dr. László Bezúr 1. Determination of proteins by conventional methods and Planning of quantitative analytical methods: analyte, the electrophoretic techniques. analytical sample, sampling, analytical methods, financial 2. Use of CE and LOC. aspects. Sampling, storage of samples, preparation of samples 3. Sample preparation by pressurized liquid extraction. related to the analytical task. General rules of sampling, sta- 4. Identification of unknown compounds in a sample tistical principle, representative sample, point sample, com- extraction by HS-GC-MS and ATD-GC-MS (LRMS) posite sample, average sample, continuous and discrete sam- 5. Identification of unknown compounds in a sample pling. Typical cases of sampling, standard methods: direct extraction by HRGC-HRMS. sampling from gases, liquids, solid materials, sampling of waters, sampling of soils, sampling of waste, sampling of air, Bioanalysis and Study of Metabolites sampling of point sources, sampling of cereals, sampling in the steps of chemical processes. BMEVESAM204 Storage of samples, pretreatment of samples, homogeniza- Dr. György Pokol tion, size reduction, milling, crushing, grinding, dividing, unit Sample preparation, special types of detectors. Analysis of operations and instrumentation. Drying of samples: dry con- biological samples of very low drug concentration. tent, loss on dry, freeze drying. Ashing of samples, loss on ash, Regulations of health authorities concerning bioanalytical ash content. Filtration of samples, filters, vacuum and pres- methods and pharmacokinetic studies. Pharmacogenetics, sure filtration, apparatus for filtration. polymorfism and their methods of anaysis. Monitoring of indi- General and specific extraction: extraction, evaporation, vidual drug level and its methods of analysis. The role of lab- selective evaporation. Separation, liquid-liquid extraction, oratory in clinical pharmacological studies. supercritical extraction. Dissolution of samples: dissolution, liquid extraction, high pressure, ultra-sonic extraction. Degradation of organic mate- Branch of Chemical and Process rials: dry ashing and acid digestion. Application of different Engineering acids and acid mixtures for digestion. Microwave digestion. Flux methods for minerals. Process Modelling and Process Design Structure Elucidation of Organic Compounds II. BMEVEKFM101 BMEVESAM303 Dr. Endre Rév Dr. Áron Szöllõsy, Dr. András Simon After a short overview of problems and applicable The NMR experiment. The most important NMR parame- methodologies in process modelling, the most frequently ters: the chemical shift, the coupling constant and the relax- used problem types and their solution methods are discussed. ation time. The connection of the chemical structure with the Energy exchange and heat exchanger network synthesis, as NMR parameters. One- and two-dimensional NMR meth- well as material exchange network synthesis problems and ods.and their application in the structure determination. methods are discussed in details. as well as the problems of Recent results in Mass Spectroscopy. Diffraction Methods. X- synthesizing non-conventional distillation systems involving Ray and electron diffraction methods and their application to energy saving and separation of highly non-ideal mixtures. A organic compounds modern methodology for exploring feasibily regions of batch Practice: guided evaluation of one- and two-dimensional extractive distillation is also treated. Basic scheduling prob- NMR spectra. lems in chemical and related industries are discussed.

80 FACULTY OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Branch of Industrial Pharmaceutics Energy production with conventional and novel methods BMEVEKFM302 Pesticides Dr. György Pátzay BMEVESZM403 Energy definitions, role of energy, forms of energy. Energy Dr. Imre Petneházy transformations, efficiencies, losses. Energy resources, techni- The subject gives an overview in the most important basic cal systems in energetics, Energy supply in the world, EU and knowledge.The most important herbicides, insecticides and Hungary. Fossile energy resources and transformation tech- fungicides are discussed together with the synthetic proce- nologies. Environmental and economical aspects. Fuels. Gas dures of the agents and a short description of the agent's bio- hydrates. Energy statistical data, tendencies, resources and logical effect. Synthetic methods for carbonic acides deriva- reserves. Energy transportation and storage technologies. tives, phosphoric esters and heterocyclic compounds will be Renewables and their future role. Carbon dioxide capture discusse in detail. The basic formulation methods and enviro- technologies. Thermodynamic aspects of energy production mental aspects will also be mentioned. Carnot, Rankine and Brayton cycles. Efficiencies and devel- opmenets, cogeneration and combined cycles. Water in energy production. Role of hydrogen int he future energy produc- Pharmaceutical Technology tion. Heat pumps and fuel cells. Nuclear energy production, BMEVESZM202 fission and fusion. Dr. Zoltán Hell Comparison of different production strategies of a pharma- Modern Separation Technologies cologically active substance. Modification of the technologies BMEVEKFM104 for the sake of the raw material source, of the thrift, of new operational methods, etc.) Environmental safety in the pro- Dr. Edit Székely duction of pharmacologically active substances, the ques- Separaion technologies in vacuum: sublimation, liofilisa- tions of the reusability of solvents and reagents. Technological tion, short path distillation, molecular distillation. Membrane and operational problems during the production. The stu- separation: microfiltration, ultrafiltration, nanofiltration, dents can design synthesis lines for a selected active com- reverse osmosis, gaspermeation, pervaporation, membrane- pound. distillation, liquid membranes, modeling and scale up. Supercritical fluids: GRAS (generally regarded as save) solvents, physio-chemical properties of supercritical solvents, high pres- Formulation of Biologically Active Materials sure phase-equilibria, extraction and separation, connection to BMEVESZM404 other separation processes, fractionated separation, preparative Dr. György Marosi supercritical fluid chromatography (simulated moving bed Introduction, basic terms, mechanisms of biological trans- chromatography), modeling and scale up. Applications in port, toxicological aspects in the technology of pharmaceuti- chemical, food and pharma industries, in biotechnology and cals and other biomaterials, classification of the products, enviromental applications. Special applications. characteristics of incoherent, coherent systems considering their characteristic materials, control of drug-release, qualita- Industrial Organic Chemistry tive, quantitative and structural analysis. Sustained and con- BMEVESZM204 trolled release from capsules, micro- and nanocapsules, implants, transdermal systems, products of ophtalmology and Dr. György Keglevich, Dr. Alajos Grün inhalation aerosols. Technology of aseptic production, pack- Systematic discussion of the most important basic process- aging of pharmaceutical products. es in industrial organic chemistry, such as alkylation, acyla- tion, halogenation, nitration, sulfonation, oxidation, reduction, hydrogenation, hydroformylation, reactions with CO, diazota- Industrial Organic Chemistry tion and coupling.. The role of technological parameters like BMEVESZM102 stirring, temperature, cooling, portioning of the reactants, pres- Dr. György Keglevich, Dr. Alajos Grün sure, shift of equilibrium. Connection of basic processes to A short summary is offered on the most important basic form technologies on the example of processing poliuretanes, processes used in the pharmaceutical industry. These are epoxy resins and a few effective substances of drugs. alkylations, acylations, sulfonations, nitrilations, halogenations, reductions, oxidations and special transformations. The Petrochemistry possibilities for the application of the basic processes are discussed in details via the relevant steps of the synthesis of BMEVEKFM402 medicinal effective substances. C-, O-, and N- alkylations, O- Dr. György Pátzay and N- acylations, chlorosulfonations, reductions, hydro- Introduction, raw materials arising from the crude oil dis- genations, oxidations, Darzens condensations, cyclinations tillation, natural gas utilization in the chemical industry, syn- and special transformations are discussed. A special stress is thesis gas production, steam-cracking, processing of its prod- laid on the point of views of the selection of the appropriate ucts, methanol synthesis, formaldehyde production, carbony- synthetic methods and on environmental friendly approaches. lation of methanol, MTBE, ETBE, oxo-synthesis, acetalde- hyde, acetic acid, vinylacetate, metacrylate, vinylchloride, ethylene oxide-glycol-ethanolamine, propylene oxide, acry- Medicinal Chemistry lonitrile, butadiene, isoprene, linear olefins, ALFOL, SHOP. BMEVESZM203 Processing of aromatic compounds, benzene-cyclohexa- Dr. Ferenc Faigl ne, phenol-cyclohexanone, PAH, TPA, MAA, adipic acid, Fundamental conceptions in medicinal chemistry. hexamethylene diamine, caprolactam. Communications among the human cells, primary and sec- At the lab practice the students get individual tasks, they ondary messengers. The four families of receptors, mechnism collect information about one process, they carry out meas- of function. Dugs of neurotransmitters and their receptors. urements in a lab-scale apparatus, evaluate the results and Drugs of hormons and their receptors. Other mechanisms of report about them in written and oral form at the end of the drug action. Cell membranes, drug actions on the nucleic semester. 81 BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS acids. Vitamines and medicines of the blood formation sys- Theory of copolymerization. Characteristics of anionic tem. In the framework of laboratory practice the students and cationic polymerization. Stereospecific polymerization. have to prepare biologically active compounds in multistep Mechanism and kinetics of polycondensation and polyaddi- synthesis to learn the required functionalisation of lead mole- tion reactions. Chemical reactions of polymers. Types of cules. The students has to determine the structure of the syn- cross-linking reactions. Degradation and stabilization of poly- thetised compounds using NMR and other spectroscopic mers. techniques. Composites Branch of Polymer Technology BMEVEFAM301 Dr. Béla Pukánszky The importance of polymer blends and composites, fields Application of Plastics of application, trends and directions in development. BMEVEFAM402 Particulate filled polymers. Interfacial interactions. The struc- Dr. Erika Bódi Fekete ture of particulate filled polymers. Nanocomposites. Introduction. State and growth of the plastic industry, role Miscibility of polymers, phase diagrams. Correlation between of plastics in the economy. Physical characteristics and the miscibility, structure and blend properties. Compatibilization determination of the processability of plastics. Thermal char- by physical and chemical methods, blending agents, modi- acteristics of plastics and their measurement. Mechanical fied polymers. Specific groups and reactions. Components of properties of plastics and their determination. Solution of fiber reinforced composites. The use of natural fibers in com- practical problems with the help of the techniques presented posites. Structure of fiber reinforced composites, long and above. Plastics in packaging. Plastics in construction. Plastics short fiber reinforcement. Stress concentration, thermal stress- in the automotive and machine industry. Other application es, adhesion. areas of plastics. Introduction of a new product, product design. Laboratory practice Branch of Textile Technology Machines and Technologies in Polymer Processing Polyreactions BMEVEFAM305 BMEVEFAM102 Dr. Alfréd Menyhárd Dr. Emilia Csiszár Introduction. Extrusion: constitution of an extruder, operation of an extruder, extruder screws, choosing the proper Types of polyreactions: polymerization, polycondensation, screw for a polymer. Characteristics of an extruder screw and polyaddition and other new polymerization reactions (tem- its optimal operational point, film blowing, sheet extrusion. plate polymerization, metathesis polymerization). Wire coating, profile extrusion, filament extrusion, coextru- Classification of chain polymerization reactions: radical, sion. Injection molding: Tool designing, simulation software. anionic, cationic and stereospecific polymerization. Theory Particular injection molding techniques: Gas and water injec- of free radical polymerization. Mechanism of chain propagation, Injection molding on films, Injection molding on textiles tion, termination and chain transfer reactions. Inhibition of Laboratory practice: Visits in plants. radical polymerization. Kinetics of radical polymerization. Theory of copolymerization. Characteristics of anionic and cationic polymerization. Stereospecific polymerization. Polymer Physics Mechanism and kinetics of polycondensation and polyaddi- BMEVEFAM202 tion reactions. Chemical reactions of polymers. Types of Dr. Béla Pukánszky cross-linking reactions. Degradation and stabilization of poly- Introduction. Terms and definitions: monomer, polymer, mers. homo- and copolymer. Structure of the polymer, segments, entanglement. Supermolecular structure, amorphous and Composites crystalline materials. The individual chain. Shape, conforma- BMEVEFAM301 tion, conformation distribution. The freely joined chain model. Interactions, solutions, determination of molecular Dr. Béla Pukánszky weight. Phases and physical states, termomechanics. Rubber The importance of polymer blends and composites, fields elastic state, thermodynamics. Rubber elastic state, kinetics. of application, trends and directions in development. Flow, rheology. Measurement of viscosity. Glassy state, frac- Particulate filled polymers. Interfacial interactions. The structure, polarization optics. Crystalline polymers, structure. ture of particulate filled polymers. Nanocomposites. Crystallization kinetics, melting. Structure-property correla- Miscibility of polymers, phase diagrams. Correlation between tions, plasticization. miscibility, structure and blend properties. Compatibilization by physical and chemical methods, blending agents, modified polymers. Specific groups and reactions. Components of Polyreactions fiber reinforced composites. The use of natural fibers in com- BMEVEFAM102 posites. Structure of fiber reinforced composites, long and Dr. Emilia Csiszár short fiber reinforcement. Stress concentration, thermal stress- Types of polyreactions: polymerization, polycondensation, es, adhesion. polyaddition and other new polymerization reactions (tem- plate polymerization, metathesis polymerization). Classi- New Application and Technologies of Fibres fication of chain polymerization reactions: radical, anionic, BMEVEFAM302 cationic and stereospecific polymerization. Theory of free radical polymerization. Mechanism of chain propagation, ter- Dr. Judit Borsa mination and chain transfer reactions. Inhibition of radical Modification of natural fibres (plasma treatment, chemical polymerization. Kinetics of radical polymerization. reactions, production of copolymers by grafting); manufacture of man made fibres in traditional and new fibre-forming processes, micro- and nanofibres, high performance (high 82 FACULTY OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY modulus, high tenacity) fibres (aramid, polyethylene gel, car- Polymer Physics bon, ceramics, glas), chemicals resistant fibres, heat resistant fibres; new technologies in textile finishing (biotechnologies, BMEVEFAM202 supercritical fluids, ultrasound); functional textiles (e.g. super- Dr. Béla Pukánszky absorbent, antimicrobial, conductive, UV absorber). Introduction. Terms and definitions: monomer, polymer, Laboratory practice: application of enzymes; modification of homo- and copolymer. Structure of the polymer, segments, natural fibre, characterization of modified fibre; manufacture entanglement. Supermolecular structure, amorphous and of fibre reinforced composite and its investigation. crystalline materials. The individual chain. Shape, conformation, conformation distribution. The freely joined chain Basic Processes in Textile Chemical model. Interactions, solutions, determination of molecular weight. Phases and physical states, termomechanics. Rubber Technology elastic state, thermodynamics. Rubber elastic state, kinetics. BMEVEFAM401 Flow, rheology. Measurement of viscosity. Glassy state, frac- Dr. Judit Borsa ture, polarization optics. Crystalline polymers, structure. The most important methods for study the structure of Crystallization kinetics, melting. Structure-property correla- fibres; the role of fibre structure in the processes of textile tions, plasticization. technology; adsorption, wetting, diffusion in textile chemical technology; theory of dyeing. Laboratory practice: investigation of supermolecular structure of natural and synthetic fibres (X-ray, FTIR), determination of dyes' diffusion coeffi- cients Description of M.Sc. Subjects Branch-depending Economic and Human Knowledge Subject

Intellectual Property (IP) Management Quality assurance of drug production BMEVEFAM103 BMEVESZM402 Dr. Béla Pukánszky, Jenõ Kürtössy Dr. István Csontos, Dr. Csaba Kovács IP Management in the Innovation Process. Economical Historical review, concepts, comparing GMP and ISO, basics of the IP Management. IP protection categories: patent personal conditions, keymans, trainings, quality assurance of -, utility model-, design-, trademark protection, etc. The role rooms and apparatus (IQ, OQ, PQ), documentation of of the patents in the Plastic Industry. The patenting process. method development in laboratory, development and valida- Case studies in the field of production and preparation. tion of analytical methods, documentation system of scale International IP agreements: the European Patent Convention, up, documentation system of routine production, validation the Patent Cooperation Treaty, etc. The importance of the util- of processes, validation of apparatus, quality control, quality ity model and the design protection. Definition of the trade- assurance, certificate, self checking, inspections, audits, mark protection, case studies in the field of the Plastic process control systems Industry. Hungarian and international IP databases. Quality Control (Quality Assurance) Patents in Pharmaceutical Industry BMEVESAM206 BMEVESZM401 Dr. György Pokol Dr. Ferenc Faigl, Dr. János Õri Principles and history of quality systems, the important Conceptual classes and types of patents. Possibilities for quality models. ISO 9000:2000 standard. Complex quality the legal protection of inventions developed during pharma- systems, the TQM model. Special quality models: GMP, GHP ceutical research projects. Relevant rules in Hungary, EU and and GLP in the pharmaceutical industry, in agriculture, in several other countries (USA). Licence agreements for sale of food industry end in the service sector. patents and know-hows. Patent applications, patent affairs in Food safety, HACCP, hazard analysis and critical control the practice, examples. point method in the food production and in entertainment sector. Audit and certification. Special quality control systems Control and Management Methods in the of laboratories, quality systems based on GLP standard and ISO 17025 standard, accreditation and certification. Chemical Industry Requirements of ISO 17025 standard on the control of BMEVEKFM303 administration and technical fields. Documentation, refer- Dr. Péter Mizsey, Dr. Béla Kelemen ence book of quality control and appendixes. Quality assur- Demonstration of the production chain on oil industrial ance of analytical methods, method validation. Principals, examples. Overview of the connected industrial sector and analytical parameters of performance and methods of its relations. The tools of the production control. Maximising of determination. Documentation of analytical methods, valida- profit for the long term production management. The philos- tion protocol, documentation of validation. Examples ophy of the Supply Chain Management. Model building and production control on the plant and factory levels. Overview of the operator training softwares and their targets. Case study problems and their individual solutions.