The University of sydney.edu.au/medicine

Contact us sydney.edu.au/medicine Research at Sydney [email protected] +61 2 9351 3132 Forest Stewardship Council (FSC®) is a globally recognised certification overseeing all fibre sourcing standards. This provides guarantees for the consumer that products are made of woodchips from well-managed forests and other controlled sources with strict environmental, economical and social standards. Research at Sydney Sydney at Research Medical School

About the ��� 2 Sydney Medical School ��������������� 3 Contact us sydney.edu.au/medicine [email protected] 3132 2 9351 +61 Cross-disciplinary research �������� 4 Research at Sydney Medical School ����������������������������7 Cancer ��������������������������������������� 8 Obesity, diabetes and cardiovascular disease ��������������10 Infection and immunity ������������� 12 Neuroscience and mental health ���������������������������� 14 Lifespan research ��������������������� 16 Meet our most highly cited scholars ��������������������������� 19 Research training ��������������������� 20 Research partners and collaborations ������������������� 22 Achieving our vision through philanthropy ��������������� 23 sydney.edu.au/medicine

About the University of Sydney

Australian innovation and research is recognised on the international stage. The University of Sydney is regularly ranked in the top 50 universities worldwide.*

Research at Sydney Medical School By uniting expertise across disciplines, we make a real difference to our understanding of today’s world.

Our 60,000 students – including Since 1850, the University of Key facts international students from more Sydney has led the way in setting than 140 countries – benefit new directions for society. −− year of foundation: 1850 from exceptional facilities and Leadership has always been at the −− student enrolments: 60,000 our innovative edge and drive core of our values. Our aim is to −− academic staff: more than 3400 to challenge traditional ways of make lives better – by producing thinking. They have opportunities leaders who can meaningfully −− All of our research performed to contribute to research that serve all of our communities at above or well above world pushes the boundaries and makes every level. standard in the most recent a meaningful, real-world impact. The cross-disciplinary nature Excellence in Research Our partners and students join of our faculties allows us to for rankings

The University of Sydney an inspiring network of leading offer the widest range of −− number of alumni worldwide: academics and distinguished academic programs of any more than 300,000 alumni. We’ve taught more than Australian university. −− student union clubs and 140 Olympians, seven prime societies: more than 200, ministers, two Nobel laureates, including 43 sporting clubs. three astronauts, 110 Rhodes scholars and one Pulitzer

Page 2 Prize winner. *QS World University Rankings 2016-17 Sydney Medical School

Since 1856 Sydney Medical School has been working to improve human health and welfare through education, research and the provision of healthcare.

Education Research Healthcare Sydney Medical School is Sydney Medical School is Nationally and internationally, dedicated to the development dedicated to improving health Sydney Medical School aims to of caring, clinically outstanding, through excellence in research, advocate for and take a leadership research-capable and globally creating new knowledge and role in contributing to high-quality aware graduates who have the fostering innovation and healthcare and wellbeing. capabilities to become leaders research at the highest level, in medicine, public health across the disciplines of basic Our staff play a major role in the and research. science, clinical medicine and provision of healthcare to the public health. people of , and Each year we teach more than in a number of countries in our 2000 undergraduate students Our large research portfolio region. They are leading clinicians across science, medical crosses the full spectrum, from who are actively involved in science and health science. the molecular basis of disease the evolution of care and hold Another 1200 are enrolled in to public health measures and key roles in government and our specialist graduate medical control of epidemics. non-government organisations, program, with more than 1100 hospitals and other major training to become postgraduate Our research is focused on health providers. researchers. both discovery and translating Sydney Medical School discoveries into improved We teach a large number of healthcare, with major programs postgraduate courses that provide of research into diseases and continuing education for medical health challenges of national and and other health professionals. international significance. Page 3 Cross-disciplinary research sydney.edu.au/medicine Research at Sydney Medical School

Sydney Medical School produces Clinical schools high-impact research that Our clinical schools based at major affiliated teaching hospitals in Sydney and across NSW addresses the most important include: global health issues in our areas −− Royal Prince Alfred Hospital of research strength. −− Royal North Shore Hospital −− Our multidisciplinary research approach brings −− Children’s Hospital at Westmead together the complementary expertise of −− Concord Hospital the University of Sydney’s faculties, centres −− Nepean Hospital and institutes with that of our affiliated teaching hospitals, institutes and international −− Sydney Adventist Hospital

The University of Sydney research partnerships. −− Dubbo Base Hospital −− Orange Hospital −− Lismore Hospital −− Broken Hill Hospital. Page 4 Multidisciplinary centres and institutes Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders Our scholars, students and partners also benefit The Boden Institute is a joint initiative of the from the facilities of our affiliated centres. faculties of Health Sciences, Medicine and Science, administered through Sydney Medical School. This centre seeks to find solutions to some of The institute is committed to reducing the individual humanity’s greatest health challenges: obesity, and societal impact of obesity, eating disorders and diabetes, cardiovascular disease and related lifestyle-related chronic diseases such as type 2 conditions. At the centre’s heart is a $385 million diabetes, heart disease, hypertension, cancer, research and education hub. mental illness and osteoarthritis. −− sydney.edu.au/perkins −− sydney.edu.au/medicine/research/units/boden

Brain and Mind Centre Bosch Institute This centre reduces the burden of disease due This institute is a major centre for medical research to brain and mind disorders through research, at the University of Sydney. It brings together basic education and clinical services. It develops new and clinical research scientists to tackle major procedures, technologies and medicines and unsolved questions about the human body in health provides access to the most advanced treatments and in illness. for mental and neurological disorders. −− sydney.edu.au/medicine/bosch −− sydney.edu.au/brain-mind Centre for Education and Research on Ageing The Poche Centre for Indigenous Health The centre is Australia’s premier academic Following a generous donation from philanthropist organisation for the study of ageing and age-related and Aboriginal health advocate Mr Greg Poche, the diseases. Through innovative and multidisciplinary Poche Centre for Indigenous Health was established research, the centre aims to expand and share Cross-disciplinary research in 2008 at the University of Sydney. knowledge of human ageing, so that the health and quality of life for older people can be improved. The centre works across the University’s health −− sydney.edu.au/medicine/research/units/cera/ faculties in three key areas:

−− Healthy kids Centre for Values, Ethics and the Law in Medicine −− Healthy teeth (VELiM) −− Healthy hearts. VELiM is a centre for academic research, teaching and learning in bioethics and the medical In each of these areas, the centre supports clinical humanities, and for ethical consultation and services, training, scholarships and research with discussion. The centre stimulates creative thought, the express purpose of improving the health of dialogue and action, engaging different disciplinary Aboriginal and Torres Strait Islander people and perspectives, and fosters a community based on communities. It provides specialist services free of collegiality and critical inquiry. charge to thousands of Aboriginal people each year −− sydney.edu.au/medicine/velim/ and their program of research ensures that the work they do genuinely makes a difference. −− sydney.edu.au/medicine/poche Page 5 sydney.edu.au/medicine

Marie Bashir Institute for Infectious Diseases Pain Management Research Institut and Biosecurity Established in 1990, the institute is a joint initiative This institute is committed to meeting the between the University of Sydney and Royal North challenge of emerging and re-emerging infectious Shore Hospital. The institute pursues its broad diseases, major causes of morbidity and mortality, goal of improving human health by conducting socioeconomic disruption and economic instability. basic and clinical research programs, operating a national and international education program and, The institute’s vision is to improve understanding in collaboration with the Pain Management and of complex interactions that fuel the emergence Research Centre, treating patients with acute pain, and spread of infectious diseases, and, as a result, cancer pain, and chronic non-cancer pain. combat and lessen their resulting health and −− sydney.edu.au/medicine/pmri socioeconomic impacts. −− sydney.edu.au/mbi Save Sight Institute The Save Sight Institute is a not-for-profit Menzies Centre for Health Policy organisation working with government and This centre is the leading independent academic community to save sight. It incorporates the Research at Sydney Medical School voice on health policy in Australia. It brings together University of Sydney’s Discipline of Clinical scholars and practitioners with broad expertise Ophthalmology, Lions NSW Eye Bank, Foresight in health policy, economics and health services Australia and Sight for Life Foundation. research to produce high-quality analyses of current health policy issues, deliver annual public seminars, The Save Sight Institute is one of the top three education programs and undertake comprehensive ophthalmic research institutes in Australia research projects. The centre’s research program and is internationally recognised as a centre addresses five themes: policies for health futures, of innovative research into ophthalmology and value in healthcare, serious and continuing illness, as a centre of excellence for clinical research, equity and governance. learning and teaching. −− sydney.edu.au/medicine/public-health/ −− www.savesightinstitute.org.au menzies-health-policy

NHMRC Clinical Trials Centre This centre runs large mulitcentre investigator‑initiated clinical-trials, works with Australasian and international collaborative research

The University of Sydney groups, investigates evidence, develops new clinical research methods, and offers clinical research education programs. The centre aims to translate research evidence into improved health outcomes. −− ctc.usyd.edu.au/ Page 6 Research at Sydney Medical School Tackling global health issues

At Sydney Medical School we are dedicated to Global rankings improving human health through translational research and innovation at the highest level. Our performance in national and international rankings reflects our status as a leading medical Sydney Medical School has a large research portfolio school. We’re placed: spanning basic science to the genetic causes −− 17th in the medicine category of the 2016-17 of disease, clinical medicine and public health QS World University Rankings by subject campaigns that could save millions of lives. −− 35th in the clinical, pre-clinical and health category of the Times Higher Education We are the most research-intensive faculty at the World University Rankings 2016-17 University of Sydney, generating close to half of −− at the highest level (5) in the Excellence the University’s total research income. In 2015 the in Research for Australia ratings for school’s researchers published more than 4000 clinical medicine, public health, publications and were awarded research and and health services research. fellowships worth $170 million.

Our research strength lies in our multidisciplinary Latest achievements approach, which unites the complementary −− The University of Sydney received $22 million expertise of the University’s faculties, centres and of the $190 million awarded by the National institutes with that of our major affiliated teaching Health and Medical Research Council (NHMRC) hospitals and international research partnerships. in 2016, with 34 successful applications to advance research-led discoveries and improve The University has enormous expertise in the the diagnosis, treatment and cure of illnesses. enabling sciences, including physics, chemistry Research at Sydney Medical School and biology and across the University’s four other −− In the major category of NHMRC project health-related faculties: Health Sciences, Pharmacy, grants, the University was awarded $57.2 Dentistry and Nursing. million with 53 projects supported. −− We have more than 1100 higher degree research students and more than 1600 active researchers. Page 7 Cancer Reducing risk, improving detection, better patient care and increasing survival

Sydney Medical School’s Research highlights sydney.edu.au/medicine cancer researchers cover the spectrum, from fundamental −− Professor Diona Damian recently led a study which found that a year of treatment with nicotinamide, cell biology, which sheds light a form of vitamin B3, significantly lowered the on cancer initiation, to cancer risk of common, non-melanoma skin cancer in high-risk patients, a breakthrough that could control and survival. save the nation more than $500 million annually. −− Professor Graham Mann and his team are Our researchers run major programs looking internationally recognised for their work at the causes of cancer, including the impact on mapping and isolating new genetic risk of cancer-causing agents such as chemicals, factors for melanoma, a disease that kills radiation, viruses and human behaviour. The about 2000 Australians annually and takes a school also runs programs examining biological disproportionately high toll on young adults. factors that can reduce or increase cancer risk, −− In partnership with the Northern Sydney Cancer such as inflammation and DNA damage. Centre, we are leading a world-first clinical trial using a GPS-like tracking system to improve The University’s cancer research programs prostate cancer radiotherapy treatment. The focus on clinical and translational excellence. approach could see cancer patients cured Our current NHMRC grants highlight cancer with radiation in just one to two weeks of Research at Sydney Medical School prevention and screening, cancer genetics, and treatment, with very low side effects. the development of new drug, cell and radiation treatments, with application in a wide number of −− Our researchers are fundamentally advancing cancers including leukaemia, melanoma, cervical, our understanding of ageing and cancer liver and breast cancer. by demonstrating the structure of active chromosomal telomeres and the role of the alternative pathway for telomere lengthening. −− Researchers in the School of Public Health are leading the world in tobacco control. Evidence they gathered to support plain packaging of cigarettes was highly instrumental in introducing Australia’s pioneering plain packaging legislation, which has helped reduce smoking rates in Australia to their lowest ever levels. The legislation has also been adopted by a number of other countries around the world. The University of Sydney Page 8 Meet our researchers

Professor Stephen Clarke Professor Graham Mann Stephen Clarke is a Professor of Medicine at Sydney Graham Mann is a Professor of Medicine at Sydney Medical School and a Senior Staff Specialist in Medical School and an internationally acclaimed

Medical Oncology at Royal North Shore Hospital. researcher in the field of cancer genetics. Cancer

Having led research to identify how inflammatory While leading melanoma research programs for the factors impact response to cancer drug treatment NHMRC, Westmead Institute for Medical Research, and survival, Professor Clarke’s work has evolved to Cancer Institute NSW and the Melanoma Institute of look at how interventions before treatment might Australia, Professor Mann and his team have recently improve patient wellbeing, the effectiveness of isolated new genetic risk factors for melanoma in treatment and survival. the Australian population.

Professor Mann is currently investigating the molecular determinants of risk, progression and treatment response in melanoma, supported by major NHMRC program grants. He chairs the University of Sydney’s Cancer Research Network. Page 9 Obesity, diabetes and cardiovascular disease Better prevention and treatment of these conditions, with medical and lifestyle approaches sydney.edu.au/medicine Sydney Medical School’s obesity, −− A study led by Professor Chris Semsarian involving genetic testing revealed new insights into the diabetes and cardiovascular causes of sudden death in young Australians disease research programs and New Zealanders. The study found a cause of death in 60 percent of cases by reviewing include basic biology, clinical information from autopsies, coronial and police medicine and policy research reports. The remaining 40 percent of cases were initially unexplained at autopsy. Further testing into the most effective ways of found that one in four unexplained sudden containing risk factors. cardiac deaths had a clinically relevant genetic mutation, despite these people having structurally normal hearts. Identifying the hidden genetic We have a number of world-renowned programs causes of sudden cardiac deaths has important in the causes, prevention and treatment of heart benefits. For example, genetic testing of surviving and vascular disease, and in preventative public family members provides information that can health measures. inform prevention and reproductive options.

The Charles Perkins Centre is based in a $385 million −− A major clinical trial involving University of research and education facility at the University of Sydney researchers changed practice by

Research at Sydney Medical School Sydney dedicated to reducing the impact of obesity, showing that the drug fenofibrate reduced diabetes and cardiovascular disease. The centre the risk of amputation and need for retinal brings together research groups from the enabling laser treatment in people with diabetes. The sciences, biomedical sciences, bioinformatics, Therapeutic Goods Administration subsequently clinical research, clinical trials and health policy. approved fenofibrate in diabetic retinopathy. −− A home-visiting program to new mothers in China, supported by Sydney Medical School, Research highlights remains the only successful intervention, internationally, in preventing obesity in early life. The program also forms part of the Early −− Professor David Celermajer’s research on Prevention of Obesity in Childhood (EPOCH) early detection of cardiovascular disease has prospective meta-analysis of obesity prevention included the discovery of endothelial function trials in Australia and New Zealand. testing by non-invasive ultrasound, enabling the −− In a world first, University of Sydney and detection of vascular disease in children and University of Washington affiliate scientists young adults. This methodology has since been have collaborated successfully to grow heart used by hundreds of research groups worldwide muscle cells in sufficient quantity to repair the to diagnose and treat early atherosclerosis. The University of Sydney damaged heart of a primate after myocardial infarction. The significant breakthrough is a major step towards solving the growing epidemic of chronic heart failure, which kills more than 20,000 Australians annually. Page 10 Meet our researchers

Professor Louise Baur Professor David Celermajer Obesity, diabetes and cardiovascular disease Louise Baur is Professor in Paediatrics and Child David Celermajer is the Scandrett Professor of Health at Sydney Medical School and is one of Cardiology at Sydney Medical School and Royal Australia’s leaders in the field of research on child Prince Alfred Hospital and one of the few practising and adolescent obesity. cardiologists who is a Fellow of the Australian Academy of Science. Her research has looked at prevention of childhood obesity, the precursors of obesity, the complications Professor Celermajer’s groundbreaking research of paediatric obesity and the effective management has demonstrated that the earliest stages of of obesity and related disorders. atherosclerotic heart disease can be detected in children 10 years and younger. Professor Baur is a member of numerous government and health advisory groups, including More recently, he and his team have developed new the key NHMRC Prevention and Community Care ultrasound and MRI scanning techniques to enable Committee, and is a consultant paediatrician at the early detection of vascular disease in children and Children’s Hospital at Westmead, NSW. young adults, potentially leading to prevention of heart disease later in life.

Professor Celermajer has published more than 350 papers in the area of heart research and is the Clinical Director of the Heart Research Institute. Page 11 Infection and immunity Reducing the global impact of infectious diseases through research, capacity building and expert advice sydney.edu.au/medicine Sydney Medical School has Research highlights expertise in infectious diseases and immunological conditions, −− The Centre for Research Excellence into Critical Infections, led by Professor Jon Iredell and with cutting-edge programs based at Westmead Hospital, has developed new rapid diagnostic tests which allow in HIV, influenza, tuberculosis antibiotic treatment to be provided quickly to and malaria, as well as people in severe sepsis, dramatically reducing immunopathology and the mortality of those with critical infections. −− Our researchers informed clinical practice mechanisms of inflammation. guidelines relating to the use of intravenous immunoglobulin in suspected or proven Other areas of expertise include epidemic viral neonatal sepsis. This international neonatal diseases, infections of animal origin, multi-drug immunotherapy study saves the Australian resistance, and vaccine and drug development. health system $1 million a year. −− Research by Professor Warwick Britton and The University of Sydney’s Institute his team at the affiliated for Infectious Diseases and Biosecurity is a

Research at Sydney Medical School include programs to decrease the incidence national, Asia-Pacific and global leader in the field of tuberculosis through: early recognition and of infectious diseases and biosecurity. It brings treatment to reduce transmission; development together leading research and expertise across of new vaccines; understanding the influence a wide range of disciplines to increase capacity of genetic factors impacting its development; to detect and respond to infectious disease and developing biological markers that not only outbreaks in humans and animals. help discriminate between active infectious and latent non-infectious tuberculosis, but also help monitor the response to antibiotic therapy. The University of Sydney Page 12 Meet our researchers

Professor Tania Sorrell Associate Professor Ben Marais Infection and immunity Tania Sorrell is Professor of Clinical Infectious Ben Marais is Associate Professor in Paediatrics Diseases and Deputy Dean at Sydney Medical and Child Health at Sydney Medical School and at School and Director of the Marie Bashir Institute for the Children’s Hospital at Westmead and Deputy Infectious Diseases and Biosecurity at the University Director of the Marie Bashir Institute for Infectious of Sydney. Diseases and Biosecurity.

Professor Sorrell is also the Director of the Centre Associate Professor Marais serves on the regional for Infectious Diseases and Microbiology, Westmead World Health Organization committee that focuses Institute for Medical Research. She was a pioneer on the control of drug-resistant tuberculosis in the in the establishment of infectious diseases as a Asia Pacific region. With colleagues, he established discipline of internal medicine in Australia and is the NHMRC-funded Centre for Research Excellence Director of Infectious Diseases and Sexual Health in Tuberculosis Control (TB-CRE), which brings Services, Western Sydney Local Health District. together research interests and skills, from basic science to public health and policy implementation. Professor Sorrell serves on state and national advisory committees in infectious disease, pandemic planning for influenza, approval of therapeutic agents, and research and human ethics committees of the NHMRC. Page 13 Neuroscience and mental health Understanding the brain and nervous system, and converting discovery into treatment

Sydney Medical School’s Research highlights sydney.edu.au/medicine research into neuroscience and mental health spans the −− Research led by Associate Professor Michael Valenzuela aims to understand the competing structure and function of the forces of neuroplasticity and degeneration brain, spinal cord, peripheral in the human brain and use this knowledge to help prevent and treat dementia. His nerves and muscle. most recent research includes the use of stem cell therapy to successfully reverse the The Sydney Neuroscience Network brings signs of canine cognitive dysfunction in dogs together a pan-university, multidisciplinary (similar to Alzheimer’s disease in humans). team of researchers dedicated to pursuing and −− Professor Ian Hickie and his team’s research into developing collaborative research projects in the use of e-mental health services by young neuroscience and mental health research and Australians to manage anxiety and depression teaching across the University of Sydney. is giving young people the power to improve their own wellbeing and protect themselves It unites experts in genetics, biochemistry from lifelong mental health problems. and physiology, as well as pharmacology and −− Research by the International Multiple Sclerosis pathology, and includes all relevant faculties and Genetics Consortium – led in Australia and New affiliated teaching hospitals and institutes. Zealand by the University of Sydney – identified Research at Sydney Medical School more than 50 genetic variants associated with developing multiple sclerosis. Further work extended ‘MS genes’ to 110, refined previous associations and defined genetic overlap with other autoimmune disorders. −− Professor Tim Lambert and colleagues at the Concord Centre for Cardiometabolic Health in Psychosis are assessing the scope and severity of physical health problems in people with severe mental illness. Their research aims to identify the risk and protective factors that could be used to predict those who are most likely to develop life‑limiting physical illnesses, such as cardiovascular disease, and develop ways to determine who is most likely to benefit from early intervention. −− Professor of Psychiatry at Royal North Shore The University of Sydney Hospital, Gin Malhi has developed scans that detect early signs of depression and anxiety in young teenagers, before symptoms are apparent. Page 14 Meet our researchers

Professor Ian Hickie Professor Matthew Kiernan Ian Hickie is Professor of Psychiatry at Sydney Matthew Kiernan holds the Bushell Chair of Medical School and Co-Director, Health and Policy Neurology at Sydney Medical School, is the Head at the University of Sydney’s . of Clinical Neuroscience Research at Royal Prince Neuroscience and mental health He is one of the most influential voices in community Alfred Hospital and is Co-Director, Discovery and recognition of the burden of mental illness and Translation at the Brain and Mind Centre. Professor improved funding of mental health services, Kiernan is also the Vice-President of the Australian especially for young people. Brain Foundation.

Professor Hickie’s research and clinical and health Professor Kiernan is currently investigating services development work focuses on expansion the mechanisms and possible prevention of of population-based mental health research, neurodegeneration in motor neurone disease; improved mental health services and development chemotherapy-induced neurotoxicity; stroke; of international mental-health strategies. His current Machado-Joseph disease; spinal muscular atrophy research includes testing and delivering early and other inherited neuropathies. His team’s interventions for young people with depression, and research is intrinsically linked to the provision of improving suicide prevention in Australia. clinical services, particularly the multidisciplinary Motor Neurone Disease Clinic and diagnostic neurophysiology clinics.

Page 15 Lifespan research A whole-of-life approach to health and medical research

Sydney Medical School’s Research highlights sydney.edu.au/medicine lifespan focus brings together clinicians and researchers −− An NHMRC grant worth $2.5 million was awarded to Professor Kate Conigrave to lead a Centre working from one extreme for Research Excellence in Indigenous Health of life to the other. We have to build Aboriginal and Torres Strait Islander research capacity and progress solutions specialists from antenatal to alcohol-related health problems. medicine, neonatology, −− A global collaboration involving Sydney Medical School researchers established that paediatrics and adolescent low-dose aspirin reduced the risk of pre- medicine through to geriatrics. eclampsia in pregnancy for at-risk mothers. −− A major randomised trial involving University of Each stage of life presents opportunities for Sydney researchers established the benefits of interventions that save lives, establish healthy blood pressure lowering for the prevention of behaviours, and ensure age-appropriate recurrent stroke, irrespective of the presence management of chronic illness. Our or absence of hypertension. These results were multidisciplinary approach leads to research subsequently incorporated in all major guidelines, that improves outcomes at some of the most and have altered clinical practice worldwide. vulnerable stages of life.

Research at Sydney Medical School −− The first systematic international review of childhood vaccinations led by researchers Current highlights include: the study of from the University of Sydney found no maternal‑to‑child transmission of viruses, evidence of a link to the development of biological changes during puberty and their autism or autism spectrum disorders. effect on adolescent behaviour, and stroke −− Professor Elizabeth Elliott’s research into Fetal management in the frail and elderly. Alcohol Syndrome Disorder (FASD) has included studies on the incidence of FASD; knowledge and attitudes of health professionals and women regarding alcohol use in pregnancy and FASD; services and treatments; birth defects associated with alcohol exposure in utero; and evaluation of educational materials for health professionals and communities. Professor Elliott was the chief investigator on the Lililwan project, the first major assessment of the impact of FASD in Aboriginal communities. The University of Sydney Page 16 Meet our researchers

Professor Richard Lindley Professor Kate Steinbeck Richard Lindley is a Professor of Geriatric Medicine Kate Steinbeck is an endocrinologist and adolescent at Sydney Medical School and a Professorial Fellow at medicine physician. She is the Medical Foundation the George Institute for Global Health. Chair in Adolescent Medicine at the University of Lifespan research Sydney and a Professor and Clinical Academic in Professor Lindley’s research focuses on new the Discipline of Paediatrics and Child Health at treatments for older people, especially stroke the Department of Adolescent Medicine at the medicine. He has been an investigator in many Children’s Hospital at Westmead. clinical trials that have changed clinical practice, such as immediate aspirin for people with acute Professor Steinbeck’s research examines adolescent ischaemic stroke (International Stroke Trial), statins health trajectories and chronic illness. She leads for older people (Heart Protection Study), and a research team to address gaps in evidence in clot‑busting treatment for acute stroke (IST-3). the field, and is working to integrate research and teaching to promote youth health issues and Professor Lindley’s recent work includes a wide educate and support doctors who treat young variety of projects, from vaccination trials for people. Current research interests include puberty frail, older people to studies of influenza control hormones and their effects on health and wellbeing in nursing homes, physiotherapy techniques in adolescence, obesity in adolescents and young after stroke, and affordable stroke rehabilitation adults, the transition from paediatric to adult care, programs in India and China. He co-leads Sydney and the management of complex chronic illness. Medical School’s Healthy Lifespan Research Network and remains in clinical practice at Blacktown Professor Steinbeck co-leads the Lifespan Research Hospital in Sydney. Network, is a member of the National Youth Information Advisory Group (AIHW), and Chair of the RACP Specialist Advisory Committee for Adolescent and Young Adult Medicine. Page 17 sydney.edu.au/medicine

Professor Cheryl Jones Professor Jonathan Morris Cheryl Jones is a Professor of Paediatrics and Jonathan Morris is Director of the Kolling Institute Deputy Dean of Sydney Medical School. She is also of Medical Research and Professor of Obstetrics a paediatric infectious diseases physician at the and Gynaecology at Sydney Medical School. He also Children’s Hospital at Westmead, where she is Head holds a number of competitive grants in pregnancy of the Centre for Perinatal Infection Research. and childbirth.

Professor Jones’s main research interests are in the Professor Morris has been based at Royal North field of childhood infectious diseases, particularly Shore Hospital since 1998 where he has built up mother-to-child transmission of infections, and is director of the perinatal research group that mother‑to-child during pregnancy, and emerging extends from basic science to population health. Research at Sydney Medical School central nervous system infections. She leads a national study of encephalitis in Australian children Professor Morris’s major research interests are (the ACE study). the prediction, prevention and management of pregnancy complications. His clinical Professor Jones holds a number of NHMRC grants practice specialises in high-risk pregnancies for research into critical and emerging infectious and complications. diseases, and is a chief investigator of two NHMRC Centres for Research Excellence. Professor Jones is also an executive team member of the Marie Bashir Institute for Infectious Diseases and Biosecurity. The University of Sydney Page 18 Meet our most highly cited scholars

Four Sydney Medical School scholars are among the world’s most influential scientists in their fields as determined by the Thomson Reuters Highly Cited Researchers list for 2016.

The list names 3266 scholars whose research ranked in the top one percent of most referenced papers in their field from 2004 to 2014.

Our highly cited researchers

Professor Bruce Armstrong is Emeritus Professor Professor Robert G Cumming is Professor of in the School of Public Health. A leader in cancer Epidemiology and Geriatric Medicine in the research, Professor Armstrong is an authority School of Public Health. Professor Cumming on the causes and prevention of skin cancer and has an international reputation for his research melanoma. He has made important contributions on osteoporosis, falls and fractures. In the last to understanding the causes and control of other decade he has expanded his research to include cancers, high blood pressure and heart disease. non‑communicable diseases and ageing in He has written some 400 scientific publications developing countries in Asia and Africa. He is the and has presented at numerous national and Director of the Master of International Public international conferences. Health program, and has published more than 300 peer‑reviewed papers. Professor Cumming

Professor Adrian Bauman is Sesquicentenary is one of only 16 highly cited researchers in social Meet our most highly cited scholars Professor of Public Health, Director of the sciences at an Australian university, and one of Prevention Research Collaboration and Theme only 170 worldwide. Leader, Physical Activity, Exercise and Energy Expenditure at the Charles Perkins Centre. For Professor Mark Woodward is a Professor of more than 30 years Professor Bauman has been Biostatistics at the University of Sydney and a world leader in the study of chronic disease Director of Epidemiology and Biostatistics at the prevention and the development and assessment of George Institute for Global Health. He has led four prevention research methods. He was instrumental major international studies and directed analytical in identifying the health benefits of moderate research on three landmark collaborative studies. physical activity and reduced sitting time. His His work on cardiovascular risk scores formed the research demonstrates the need for intersectoral basis of national guidelines in Scotland, and his contributions to physical activity promotion recent work on kidney disease was used to produce programs, including sectors such as sports, new staging criteria for this disease. His total transport and urban planning. career grant awards are more than $93 million from 39 successful applications. He has written more than 400 peer-reviewed publications and two textbooks on statistical methods in medical research. Page 19 Research training

Each year, more than 200 PhD students graduate from Sydney Medical School, going on to play roles at the forefront of

sydney.edu.au/medicine health fields around the world.

Research training Research higher degrees One of Sydney Medical School’s essential roles is to We offer two research degrees for both medical and provide high-quality research training and skills to non-medical graduates: our large cohort of research students. −− Master of Philosophy (MPhil) −− Doctor of Philosophy (PhD). Our students are supervised by outstanding and committed clinicians and researchers in our centres, The Doctor of Clinical Surgery and the Master of schools and affiliated institutes and hospitals. Surgery (by research) are available for medical graduates only.

Our research teaching mission is twofold: −− to train young investigators so they are well prepared to secure successful and rewarding positions in health and medical research −− to increase the number who choose Research at Sydney Medical School careers as clinician scientists or become involved in clinical research.

In pursuit of our goal to increase the number of clinician scientists, all medical students undertake research projects as part of their medical studies. The school has also been working with the royal colleges to incorporate research as part of specialist training programs.

Sydney Medical School provides an outstanding environment for postgraduate research. With our partners in Local Health Districts and affiliated research institutes, students have access to the latest technology and up-to-date facilities.

We currently have more than 1100 research

The University of Sydney students, the majority of whom are doctoral students who have come to us from a wide range of first degrees. Page 20 Research strengths Our research strengths encompass five main Medical sciences health areas, all led by internationally acclaimed −− physiology researchers and clinicians: −− pathology −− cancer −− anatomy and histology −− obesity, diabetes and cardiovascular disease −− pharmacology −− infection and immunity −− molecular biosciences −− neuroscience and mental health −− brain and mind sciences −− lifespan. −− genetics.

Our research strengths are supported by a Public health range of enabling disciplines: −− biostatistics Clinical research −− Indigenous health

−− imaging −− global health Research training −− medicine −− rural health −− surgery −− clinical trial design −− paediatrics −− bioethics −− sleep medicine −− health promotion −− addiction medicine −− health economics −− anaesthesia −− epidemiology. −− ophthalmology −− ear, nose and throat −− emergency medicine −− general practice −− intensive care −− psychiatry −− kidney disease and transplantation −− liver and gastroenterology −− musculoskeletal health −− obstetrics and gynaecology. Page 21 Research partners and collaborations sydney.edu.au/medicine

Affiliated medical research International research institutes partnerships

−− ANZAC Research Institute Sydney Medical School has a wide −− University of Cambridge, UK international network. More than −− Centenary Institute −− University of California, 40 percent of its publications San Diego, US −− Children’s Medical

Research at Sydney Medical School have international collaborators, −− University of California, Research Institute including: San Francisco, US −− Chris O’Brien Lifehouse −− Boston University School −− University College London, UK −− George Institute for of Medicine, US −− University of Edinburgh, UK Global Health −− Chinese University of Hong Kong −− University of Glasgow, UK −− Heart Research Institute −− Fudan University, China −− University of Leicester, UK −− Melanoma Institute of Australia −− Harvard University, US −− University Medical Centre, −− Westmead Institute for −− Hong Kong University Medical Research Utrecht, Netherlands −− Imperial College London, UK −− Woolcock Institute of −− University of Otago, NZ −− Karolinska Instituet, Sweden Medical Research. −− University of Oxford, UK −− McMaster University, Canada −− University of Southern Denmark −− National University of Singapore −− University of Toronto, Canada −− Shanghai Jiao Tong −− VU University, Amsterdam, University, China Netherlands −− Stanford University, US −− University of Washington, US The University of Sydney −− University of Auckland, NZ −− University of Virginia, US −− University of Calgary, Canada Page 22 Achieving our vision through philanthropy

Sydney Medical School is deeply grateful for the financial support it receives from alumni and friends. Private donations are more important than ever as a building block of our success.

Our donors provide scholarships for students, fund By donating to Sydney Medical School Foundation novel research programs and enable us to employ you can help improve the health and wellbeing of specialist researchers and clinical leaders. both Australians and our international neighbours.

While innovative research programs provide For further information or to support the University, opportunities for the next generation of please contact: researchers, a lack of funding can prove the difference between a promising yet untested idea Division of Alumni and Development and successful treatment. +61 2 8627 8818 [email protected] The Sydney Medical School Foundation plays −− inspired.sydney.edu.au/giving an integral part in transforming ideas into internationally recognised research with real-world applications. The foundation has been the main Achieving our vision through philanthropy fundraising arm of the school for more than half a century and has contributed to myriad research and scholarship programs that specialise in areas such as cardiovascular disease, diabetes, melanoma, burn medicine, paediatrics and child health, adolescent medicine, Ménière’s disease and Alzheimer’s disease, to name a few.

The foundation has also invested in the training and education of medical students from developing countries such as Timor-Leste, and allowed students from Sydney Medical School to travel abroad to experience first hand the challenges of their international peers. Page 23 Sydney Medical School Edward Ford Building (A27) University of Sydney NSW 2006 +61 2 9351 3132 [email protected] sydney.edu.au/medicine sydney.edu.au/medicine The University of Sydney CRICOS 00026A

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16/6255 the right to make alterations to any information contained within this publication without notice.