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AAP / ASCI / APSA Joint Meeting 2017 Meeting Program & Abstracts THE PREMIER ANNUAL MEETING FOR PHYSICIAN-SCIENTISTS April 21 – 23, 2017 Fairmont Chicago Millennium Park This activity is jointly provided by Harvard Medical School. Chicago, Illinois www.jointmeeting.org Special Events At The 2017 AAP/ASCI/APSA Joint Meeting Friday, April 21 Saturday, April 22 ASCI President’s Reception ASCI Food & Science Evening 6:15 p.m. – 7:15 p.m. (ID required) Gold Room 6:30 p.m. – 9:00 p.m. Mid-America Club, Aon Center (off-site) ASCI Dinner & Featuring Poster Presentations by the ASCI’s 2017 New Member Induction Ceremony Young Physician-Scientist Award Recipients and Howard (Ticketed event) Hughes Medical Institute Medical Research Fellows. 7:30 p.m. – 9:45 p.m. AAP Member Banquet Rouge, Lobby Level (Ticketed event) How to Earn a Nobel Prize 7:00 p.m. – 10:00 p.m. Speaker: Michael S. Brown, MD Imperial Ballroom, Level B2 UT Southwestern Medical Center Can Science Avert the Decline and Fall of the APSA Welcome Reception American Empire? (Ticketed event, ID required) Speaker: Roberta B. Ness, MD, MPH University of Texas School of Public Health 9:00 p.m. – Midnight Mid-America Club, Aon Center (off-site) APSA Dinner & Founder’s Award Presentation (Ticketed event) 7:30 p.m. – 9:00 p.m. Rouge, Lobby Level Founder’s Award Recipient: Joseph Bast, PhD Founding Director, ASPA Board of Directors Charting Your Path as a Physician Scientist Dinner Speaker: Kirsten Bibbins-Domingo, MD, PhD, MAS University of California, San Francisco Dessert Reception The Premier Annual Meeting (Open to all attendees) 10:00 p.m. – Midnight For Imperial Lobby, Level B2 Physician-Scientists Sunday, April 23 APSA Residency Luncheon 12:00 p.m. – 2:00 p.m. Rouge, Lobby Level Program Contents General Program Information 2 ____________________________________________________________________________________ Continuing Medical Education Information 3 ____________________________________________________________________________________ Joint Program Planning Committee & APSA Events Committee 4 ____________________________________________________________________________________ Scientific Program Schedule 5 ____________________________________________________________________________________ Speaker Biographies 12 ____________________________________________________________________________________ Call for Nominations: 2018 Harrington Prize for Innovation in Medicine 21 ____________________________________________________________________________________ 2017 AAP/ASCI/APSA Leadership 22 ____________________________________________________________________________________ Travel Award Recipients 23 ____________________________________________________________________________________ Call for Nominations: George M. Kober Medal 25 ____________________________________________________________________________________ Joint Meeting Oral and Poster Abstracts 27 ____________________________________________________________________________________ Joint Meeting Oral and Poster Abstract Author Index 119 ____________________________________________________________________________________ Hotel Floor Plans 132 ____________________________________________________________________________________ Joint Meeting Sponsors Inside Back Cover ____________________________________________________________________________________ Future Joint Meeting Dates Back Cover ____________________________________________________________________________________ www.jointmeeting.org 1 General Program Information Registration Desk Hours Poster Session Schedule Friday, April 21 7:00 a.m. – 6:30 p.m. Friday, April 21 Saturday, April 22 7:00 a.m. – 5:00 p.m. 1:00 p.m. – 3:00 p.m. Poster Setup 6:15 p.m.– 9:30 p.m. Informal Viewing: presenters do not Sunday, April 23 7:30 a.m. – 10:00 a.m. need to be at poster Saturday, April 22 Americans with Disabilities Act TWO Poster Presentation Sessions Event staff will be glad to assist you with any special needs 8:00 a.m. – 9:00 a.m. Poster Session with (i.e., physical, dietary, etc.). Please contact the Registration Continental Breakfast Desk at the meeting if you require any special assistance. ODD numbered posters presented Joint Meeting Evaluations 11:45 a.m. – 1:30 p.m. Poster Session with Lunch EVEN numbered posters presented The AAP/ASCI/APSA Joint Meeting Planning Committee relies 1:30 p.m. – 2:00 p.m. Poster Dismantle on your input to enhance its meetings. Following the Joint Meeting, an online meeting evaluation will be emailed to all 2:45 p.m. – 3:00 p.m. Outstanding Poster Awards attendees. APSA attendees will receive a separate survey to (during Plenary III in help its planning committee enhance APSA-sponsored events International Ballroom) at future AAP/ASCI/APSA Joint Meetings. Your participation in Poster presenters should plan to be available on Saturday for this survey is greatly appreciated. their appointed poster presentation session and the resulting awards program later in the afternoon. AAP/ASCI/APSA Joint Meeting Code of Conduct Best Poster Awards We value your attendance. Our conference is dedicated Best Poster Awards will be given in the amount of $1,000 each. to providing a harassment-free experience for everyone, Members of the AAP, ASCI and APSA will judge posters on regardless of gender, gender identity and expression, age, scientific novelty, quality and clarity of presentation. Awards will sexual orientation, disability, physical appearance, body size, be presented on Saturday, April 22, from 2:45 – 3:00 p.m. race, ethnicity, or religious preference. AAP/ASCI/APSA do not tolerate harassment of conference participants in any form. A participant engaging in harassing behavior will be warned and may be asked to leave the conference with no refund. If you are being harassed, notice that someone else is being harassed, or have any other concerns, please contact a member of conference staff at the registration desk immediately. Conference staff and organizers are dedicated to making all participants feel safe for the duration of the conference. 2 AAP / ASCI / APSA Joint Meeting 2017 Continuing Medical Education Information Continuing Medical Education (CME) Accreditation Statement Information This activity has been planned and implemented in The AAP/ASCI/APSA Joint Meeting annually brings together accordance with the accreditation requirements and policies physician-scientists of all backgrounds to highlight some of the Accreditation Council for Continuing Medical Education of the best examples of translational biomedical research, (ACCME) through the joint providership of Harvard Medical to celebrate new members elected to the AAP and ASCI in School and the Association of American Physicians, the recognition of their research and leadership contributions, and American Society for Clinical Investigation, and the American to recognize the careers of physician-scientists who have had Physician Scientists Association. The Harvard Medical School major impact on their fields. is accredited by the ACCME to provide continuing medical education for physicians. Meeting Learning Objectives AMA Credit Designation Statement Upon completion of this activity, participants will be able to: The Harvard Medical School designates this live activity for a • Evaluate important recent advances in the scientific basis of maximum of 7.50 AMA PRA Category 1 Credits™. Physicians disease and therapy. should claim only the credit commensurate with the extent of their participation in the activity. • Consider novel strategies to address challenges to the physician-scientist. Claiming CME Credit and Obtaining • Determine the roles that improved understanding of these advances and strategies can play in the potential treatment Certificates of human disease. Participants will be sent a link to the online evaluation before the start of the meeting and will be required to complete the Target Audience online evaluation to receive CME credit. Once the evaluation This activity is targeted towards physician-scientists, trainees is completed, participants may print, save, or email their CME and students across a broad range of specialties including certificates or certificates of attendance (for non-physicians). basic research, cardiology/cardiovascular research, cell and Questions related to this activity or on completing this online molecular biology, endocrine and metabolism, hematology, evaluation may be directed to [email protected]. immunology, infectious diseases, nephrology, pulmonology, and others. Disclaimer CME activities sponsored by Harvard Medical School are HMS Disclosure Policy offered solely for educational purposes and do not constitute any form of certification of competency. Practitioners should HMS adheres to all Accreditation Council for Continuing always consult additional sources of information and exercise Medical Education (ACCME) Accreditation Criteria and Policies. their best professional judgment before making clinical It is HMS’s policy that those who have influenced the content decisions of any kind. The content of each presentation does of a CME activity (e.g. planners, faculty, authors, reviewers not necessarily reflect the views of Harvard Medical School. and others) disclose all relevant financial relationships with commercial entities so that HMS may identify and resolve any conflicts of interest prior to the activity. These disclosures will be provided in the activity materials for the learners along with disclosure of any commercial
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