Principles of Radiopharmacology

edited by Ha raid Deckart Nuclear Clinic, Berlin-Buch, German Democratic Republic

Peter HXox Department of , Rotterdamsch Radio-Therapeutisch Instituut, Rotterdam, The Netherlands

1987 MARTINUS NIJHOFF PUBLISHERS a member of the KLUWER ACADEMIC PUBLISHERS GROUP DORDRECHT / BOSTON / LANCASTER Contents

Chapter 1: Fundamentals of Radioactivity 12 Guenter K. Vormum Chapter 2: Modern Trends in Production with Small Accelerators ... 29 Gerd-Juergen Beyer and Rudolf Muenze Chapter 3: Generator Systems 46 Harold Deckart Chapter 4: : A Review 51 Harold Deckart Chapter 5 ; Historical Development of Radiopharmaceuticals: Bibliography . . 75 Harold Deckart Chapter 6 : Agents: Recent Developments 83 Malcolm Frier Chapter 7: Technetium-99m Radiopharmaceuticals: Structure-Activity-Relation- ships 100 Rudolf Muenze Chapter 8: Technetium-99m Radiopharmaceuticals: Their Chemical Potential and Limitations 117 Bernd Johannsen Chapter 9: Chemistry of Indium Complexes 128 Ingrid Kaempfer Chapter 10: Labelling and Analysis of Protein-Based Radiopharmaceuticals . . . 137 Gyozo A. Jdnoki Chapter 11: Labelling of Proteins with Iodine-125 as RIA-indicators 143 Eberhard H. Schmidt and Guenter K. Vormum

7 Chapter 12: Biological Aspects of Radiopharmacokinetics 155 Annemarie Blottner Chapter 13: Principles, Problems and Trends in Radiopharmacology 166 Bernd Johannsen Chapter 14: Basic Principles in Clinical Use of Stable Isotope Pharmaceuticals . . 183 Peter Krumbiegel Chapter 15: Requirements for the Development and Evaluation of New Radiophar- maceuticals 191 Gertrude Pfeiffer Chapter 16: Good Radiopharmacy Practice 199 Knud Kristensen Chapter 17: Quality Control and Effect. Technical Aspects of Electrophoresis, Paper and Thin-layer Chromato- graphy, Column Chromatography 207 Ingrid Kaempfer Chapter 18: Adverse Reactions to Radiopharmaceuticals 217 Harald Deckart Chapter 19: Pharmaceutical Interaction with Radiopharmaceuticals: I. Radioiodine-, Pertechnetate Kinetics in Endocrinology . . 224 Harald Deckart Chapter 20: Pharmaceutical Interaction with Radiopharmaceuticals: II. Various Labelled Compounds 230 Harald Deckart and Peter H. Cox Chapter 21: Radiopharmaceuticals Toxicity and Safety 240 Peter H. Cox Chapter 22: Absorbed Dose Calculations for Biologically Distributed Radiophar- maceuticals 246 Manfred Tautz Index 257