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American Endurance Ride Conference Rule 13 Appendices Revised October, 2019, for the 2019 AERC ride season

Appendix A. Prohibited Substances

Acebutolol...... Sectral Beclomethasone ...... Propaderm Carbromol ...... Mifudorm ...... Tercian Belladonna ...... Cyclospasmol Acenocoumarol ...... Megimide, Mikedimide ...... Rela, Soma ...... Merazine ...... Atrovet, Notensil, PromAce® Benazeprilat, Benazepril and MC-tab ...... Lotrel, Carphenazine ...... Proketazine ...... Phanodorm Acetaminophen ()..Tylenol, Tempra, etc. Lotensin ...... Prazinil ...... Flexeril Acetanilid ...... Naturetin ...... Rimadyl Cyclomethylcaine ...... Surfacaine ...... Diamox, Vetamox ...... Cartrol ...... Anhydron, Renazide ...... Tindal Benoxinate ...... Dorsacaine Carticaine (see ) ...... Septocaine; Cycrimine ...... Pagitane Acetophenetidin () ...... Anquil Ultracaine, etc. ...... Periactin Acetylpromazine ...... Tiadipona ...... Coreg ...... Danocrine Acetylsalicylic acid () Benzactizine ...... Deprol, Bronchodiletten (khat, kat, qat, quat, chat, catha, ...... Dantrium Abyssinian tea, African tea) Darbepoetin ...... Aranesp Albuterol ()...... Proventil, Ventolin ...... Celebrex ...... Syncurine ...... Naxcel, Kefzol Dembroxol (Dembrexine) Aclomethasone ...... Aclovate ...... Didrex (including ceftiofur, cefazolin) Demethylpyrilamine...... Sputolysin Alcuronium ...... Alloferin Benzthiazide ...... Aldocortin, Electrocortin Benztropine ...... Cogentin Chamomile...... Zyrtec Deoxycorticosterone ...... Percortin, DOCA, ...... Alfenta (BZP) betaine ...... Beta-Chlor Descotone, Dorcostrin ...... Axert ...... Bepadin ...... Nactec, Oridrate, etc. Derecoxib ...... Deremaxx Alphaprodine...... Nisentil ...... Betasone, etc. Chloraldehyde (chloral) ...... Norpromine, Pertofrane ...... Anaxyl ...... Kerlone (Alpha-Chloralose) Desonite ...... Des Owen ...... Xanax ...... Urecholine, Duvoid Chlorbutanol ...... Topicort ...... Esbatal ...... Librium ...... Dormosedan Althesin ...... Saffan ...... Akineton Chlorhexidol 2 Devil’s Claw Ambenonium ...... Mytelase, Myeuran Biriperone ...... Neohydrin ...... Azium, etc. ...... Ambril, etc. ...... Zebeta, Bisobloc, etc. ...... Trancopal ...... Cyclocort ...... Effectin 2 ...... Palfium, Narcolo ...... Moduretic; Midamor Boldenone ...... Equipoise Chlorophenesin ...... Maolate ...... Darvon Aminocaproic acid ...... Amicar, Caprocid ...... Bretylol ...... Nesacaine ...... Dalgan ...... Alphagan ...... Avloclor Diamorphine .....Gentocin, Amiglyde, Tobrex, ...... Lexotan, Lectopam ...... Diuril ...... Valium Biosol, Adspec (including , ...... Duract Chlorpheniramine ...... Chlortriemton, etc. ...... Proglycem amikacin, tobramycin, , spectinomycin ...... Oletor, etc. ...... Newiplege Dibucaine ...... Nupercainal, 2-Aminoheptane ...... Tuamine Bromisovalum ...... Diffucord, etc. ...... Thorazine, Largactil ...... Febenol, Isocom ...... Aminophyllin, etc. ...... Parlodel ...... Taractan Dichlorphenamide ...... Daramide Aminopyrine Bromodiphenhydramine Chlorthalidone ...... Hydroton ...... Surpass, Voltaren, Voltarol Amisometradine ...... Rolictron ...... Bromidol ...... Paraflex Dicumarol ...... Dicumarol ...... Solian ...... Dimetane, Disomer Cilostazol ...... Pletal Diethylpropion ...... Tepanil, etc. ...... Mitaban ...... Brotocol Cimeterol ...... Themalon ...... Elavil, Amitril, Endep ...... Pulmacort, Rhinocort ...... Tagamet ...... Florone, Maxiflor ...... Ammivin, Norvasc Bufotenine Cinchocaine ...... Nupercaine ...... Flu-Cortinest, etc. ...... Amytal ...... Bumex ...... Celex ...... Asendin ...... Marcaine ...... Tavist ...... Crystodigin ...... Temgesic ...... Ventipulmin ...... Lanoxin ...... Wellbutrin Clibucaine ...... Batrax ...... Parcodin ...... Buspar Clidinium ...... Quarezan, Clindex, etc. Amyl (Secbutobarbitone) ...... Butacaps, ...... Urbanyl Dilorazepam ...... Briantum ...... Leritine Butasol, etc. ...... Temovate ...... Cardizem ...... Anisine ...... Butyn Anisindione () ...... Fiorinal ...... Cloderm Dimethisoquin ...... Quotane Anisotropine ...... Valpin (butyl aminobenzoate) ...... Butesin Clodronate...... Osphos DMG Antipyrine ...... Hostacain Dimethylsulfoxide (DMSO) ...... Domoso Apazone () ...... Rheumox ...... Repoise (Chlormethiazole) Butoctamide ...... Listomin ...... Anafranil ...... Benadryl ...... Stadol, Torbugesic ...... Klonopin ...... , Lomotil ...... Alurate Butoxycaine ...... Stadacain ...... Catapres Dipremorphine ...... M50/50 N-butylscopolammonium .....Buscopan ...... Tranxene Dipyridamole ...... Persantine Arnica Clormecaine ...... Placacid Dipyrone ...... Novin, Methampyrone Calusterone ...... Methosorb Clothiapine ...... Entermin ...... Norpace Articaine ...... Septocaine; Ultracaine, etc. ...... Paxor ...... Trecalmo, Rize Divalproex ...... Depakote Ashwaghanda ...... Enadel, Sepazon, Tolestan ...... Esucos ...... Tenormin ...... Clozaril, Leponex ...... Dobutrex ...... Strattera (CBD) ...... Intropin Atracurium ...... Tracrium ...... Atcand ...... Aricept ...... Covatine Doxacurium ...... Nuromax Azacylonol ...... Capolen Comfrey ...... Dopram ...... Stresnil, Suicalm, Fentaz (with ...... Carbacel, Conducton Conorphone ) ...... Lentin, Doryl Corticaine ...... Ultracain ...... Doxans Bacitracin Carbamezapine ...... Tegretol ...... Cortone, etc. ...... Adapin,Sinequan ...... Lioresal + levodopa ...... Sinemet Cromolyn ...... Intel ...... Decapryn ...... Veronal ...... Clistin Crotetamide Dromostanolone ...... Drolban A. Prohibited Substances . . . Fluoroquinolones... Baytril, Cipro, Ciloxan, A180 ...... Ketalar, Ketaset, Vetalar Methandriol ...... Probolic ...... Inapsine, Droleptan, Innovar-Vet (including , , .....Anxon, Laftram, Solatran, Loftran Methandrostenolone ...... Dianabol (with Fentanyl) ) Nizoral ...... Banthine Dyclonine ...... Dyclone ...... Prozac ...... Orudis ...... Histadyl, etc. Dyphylline ...... Halotestin ...... Toradol ...... Quaalude Edrophonium ...... Tensilon Flupenthixol ...... Depixol,Fluanxol ...... Normodyne ...... Gemonil Eletripan ...... Relpax ...Prolixin, Permitil, Anatensol, etc. ...... Lamictal ...... Naptazane Eltenac ...... Katadolone Lansoprazole (metabolite enaloprilat) ...... Vasotec ...... Alphadrol Laurel ...... Tacaryl Flurandrenolide ...... Cordran Lavender Methixene ...... Trest Endorphins ...... Dalmane ...... Robaxin ...... Froben ...... Elanone-V ...... Brevital ...... Imap, Redeptin Leopard’s bane Methotrexate ...... Folex, Nexate, etc. Epinephrine ...... Flixonase, Flutide Letosteine ...... Viscotiol, Visiotal Methotrimeprazine ....Levoprome, Neurocil, etc. Epoetin alfa ...... Restas ...... Vasoxyl Ergonovine ...... Ergotrate ...... Dumirox, Faverin, etc. ...... Betagan ...... Orthoxide ...... Gynergen, Cafergot, etc. ...... Altram Methscopolamine ...... Pamine Erthrityl tetranitrate ...... Cardilate , metabolite, Fosinoprilat .....Monopril ...... Levo-Dremoran Methsuximide ...... Celontin Erythropoietin (EPO) ...... Epogen, Procrit, etc. ...... Cerebyx ...... Eltroxin, Synthroid, Soloxine, ...... Brevibloc ...... Lasix Thyro-Tabs, Thyro-Form Methylchlorthiazide ...... Enduron Esomeprazole ...... Nexium GABA (see gamma aminobutyric acid) ...... Xylocaine ...... Aldomet ...... Domnamid, Eurodin, Nuctalon ...... Neurontin Lisinopril ...... Prinivil, Zestril Methylergonovine ...... Methergine ...... Reminyl ...... Lithizine, Duralith, etc. ...... Ritalin Etanercept ...... Enbrel Gallamine ...... Flaxedil ...... Medrol Ethacrynic acid ...... Edecrin Gamma aminobutyric acid (GABA) Methylsulfonomethane ...... MSM Ethamivan Gamma-oryzanol (other than naturally occurs Loflazepate, Ethyl ...... Victan Methyltestosterone ...... Metandren ...... Placidyl in equine feeds such as rice bran/rice bran oil) ...... Imodium ...... Noludar ...... Valmid ...... Dormonort, Havlane ...... Sansert ...... Zactane ...... Doriden Loratidine ...... Claritin Ethopropazine ...... Parsidol Glycopyrrolate ...... Robinul ...... Ativan ...... Reglan ...... Zarontin ...... Noctamid ...... Metubine ...... Peganone ( guiacolate) ...... Gecolate Losartan ...... Hyzaar ...... Cardrase, Ethamide ...... Hylorel ...... Laxitane ...... Hypnodil Ethyl ...... Ismelin LSD (methyldihydromorphinone) Ethylaminobenzoate (Benzocaine) ..Semets, etc. ...... Wytensin ...... Lopressor ...... Maxibolin, Organon ...... Paxipam Macrolides...... Zithromax, Biaxxin (including Flagyl Ethylisobutrazine ...... Diquel ...... Halog , azithromycin, ) ...... Melex ...... Dionin Halobetasol ...... Ultravate sulphate administered for the Mexilitine ...... Mexilil Ethylnorepinephrine ...... Bronkephrine ...... Haldol purpose of and at the levels of providing ...... Posicor a calming/tranquilizing effect. Magnesium ...... Duranest ...... Somelin ...... Versed sulphate administered as an electrolyte Hemoglobin glutamers .....Oxyglobin Hemopure ...... Pro-Amiline Etifoxin ...... Stresam supplementation is allowed. Milenperone ...... Depas, Pasaden ...... Ludiomil ...... Corofundol ...... Lodine ...... Sanorex ...... Loniten ...... Indunox ...... Axiten, Dormate, Capla Hexafluorenium ...... Myalexen Mirtazepine ...... Remeron ...... Inversine ...... Evipal ...... Cytotec HCl ...... M99 ...... Antivert, Bonine ...... Tral Mivacurium ...... Mivacron ...... Arquel ...... Cyclaine ...... Provigil ...... Gaster, Pepcid ...... Lucidiril, etc. ...... Homapin Moexipril (metabolite, moexiprilat) ...... Uniretic ...... Felbatol ...... Nobrium, etc. Homophenazine ...... Pelvichthol ...... Moban ...... Plendil ...... Domitor Hops ...... Elocon Fenarbamate ...... Tymium ...... Medriusar, etc. ...... Singulair ...... Cincopal ...... Ponstel ...... Apresoline ...... Luvatren ...... Myalex ...... Mobic Hydrochlorthiazide ...... Hydrodiuril ...... Pondimin ...... Eunerpan (dihydrocodienone) ...... Hycodan Mosaprimine ...... Corlopam ...... Namenda () ...... Cortef, etc. ...... Nalfon ...... Saluron ...... Anthraxan, Relafen, Reliflex ...... Berotec Meparfynol ...... Oblivon ...... Dilaudid Nadol ...... Corgard ...... Respiride, Respan, etc. Mepazine ...... Pacatal Hydroxyamphetamine ...... Paradrine Naepaine ...... Amylsine Fentanyl ...... Sublimaze ...... Cantil ...... Atarax ...... Nubain Meperidine ...... Demerol Hyoscine ...... Allegra ...... Tolserol Ibomal ...... Noctal ...... Nalline, Lethidrone ...... Equioxx ...... Control, etc. ...... Motrin, Advil, Nurpin, etc. ...... Narcan ...... Idalon ...... Wyamine ...... Corvert ...... Revia ...... Idalon, Idarac ...... Mesantoin ...... Ventavis ....Nandrolin, Laurabolin, Durabolin ...... Sedalande Mephobarbital () .Mebaral ...... Imavate, Presamine, Tofranil ...... Privine Flucinolone ...... Synalar, etc. ...... Carbocaine Indomethacin ...... Indocin ...... Equiproxen, Naprosyn ...... Erispam ...... Equanil, Miltown Infliximab ...... Remicade ...... Amerge ...... Alforone, etc. Ipratropium ...... Tilade ...... Mercuhydrin Irbesarten ...... Avapro ...... Serzone Flumethasone ...... Flucort, etc. Merbaphen ...... Novasural Isapirone Flumethiazide ...... Ademol Mercaptomerin ...... Thiomerin ...... Marplan ...... Prostigmine ...... Sibelium Mercumalilin ...... Cumertilin Isoetharine ...... Bronkosol ...... Cardine ...... Bronilide, etc. ...... Salyrgan ...... Predef ...... Procardia .... Rohypnol, Narcozep, Darkene, Mesalamine ...... Asacol Hypnodorm ...... Nifluril ...... Serentil ...... Banamine ...... Octin, Octon Night shade ...... Talis ...... Synalar ...... Darbid ...... Coramine Metaproterenol ...... Alupent, Metaprel ...... Licon, Lidex Isoproterenol ...... Isoprel ...... Aramine Fluopromazine ...... Psyquil, Siquil ...... Isordil Nitazoxanide Navigator ...... Skelaxin Fluoresone ...... Caducid ...... Maxicam ...... Erimin ...... FML ...... Vasodilan ...... Nemotop Methachloline Fluoroprednisolone ...... Predef-2X ...... DynaCirc Nitrazepam...... Mogadon ...... Dolophine Itraconcazole Sporanox ointment kava ...... Desoxyn A. Prohibited Substances . . . ...... Propadrine Rifampin ...... Italprid, Luxoben, etc. Nitroglycerin ...... Dilantin ...... Surgam ...... Axid ...... Eserine ...... Component of Telazol Nordiazepam...... Calmday, Nordaz, etc. Tiludronate...... Tildren ...... Alvodine, Cimadon ...... Yutopar ...... Tolopelon Norethandrone ...... Orap Rivastigmine ...... Exelon ...... Blocardrin Nortestosterone ...... Domar Rizatripan ...... Maxalt ...... Tonocard ...... Aventyl, Pamelor ...... Viskin Rocuronium ...... Zemuron ...... Grandaxain, Seriel Nylidrine...... Arlidin ...... Dipiperon ...... Vioxx ...... Priscoline Olanzepine...... Zyprexa Pipecuronium ...... Arduan ...... Sedivet ...... Tolectin Olmesartan...... Benicar ...... Naropin Topirimate ...... Topamax Olsalazine...... Dipentum ...... Psymod, Quide Torsemide () ...... Demadex Omeprozole administered in any amount ...... Metycaine Salicylate ...... Ultram higher than the preventive dose of 1.1 mg/kg ...... Lonseren, Piportil Trandolapril (and metabolite, trandolaprilat) per day ...... Gastroguard, Ulcerguard, ...... Dataril, Gerondyl, etc. (Hyoscine) ...... Triptone Tarka Prilosec, Losec (Quinalbarbitone) ...... Seconal Tranexamic acid ...... Norlfex ...... Maxair ...... Eldepryl, Jumex, etc. ...... Parnate Oxandrolone...... Anavar ...... Lustral, Zoloft ...... Desyrel ...... Daypro, Deflam Pirenzapine ...... Gastrozepin ...... Meridia ...... Finoplix ...... Serax ...... Arelix, Tauliz ...... Viagra ...... Inolin ...... Serenal Skullcap ...... Vetalog, etc. ...... Trileptal ...... Feldene Snake Venoms ...... Dyrenium ...... Trasicor cacodylate ...... Halcion PolymixinB Somatropin ...... Nutropin Tribromethanol ...... Percodan ...... Renese Somatrem ...... Protropin Tricaine methanesulfonate ...... Finquel ...... Afrin Ponazuril Marquis ...... Betapace, Sotacor ...... Naqua, Naquasone Oxymetholone...... Adroyd, Anadrol Pramoxine ...... Tronothaine Spiclomazine Trichloroethanol ...... Numorphan ...... Verstran, Centrax Tricholoethylene ...... Trilene, Trimar Oxyperitine...... Forit, Integrin ...... Minipress Spirapril, metabolite Spiraprilat ...... Renomax ...... Triclos ...... Tandearil ...... Delta-Cortef, etc. Spironalactone ...... Aldactone ...... Pathilon ...... Daricon ...... Meticorten, etc. Stanozolol ...... Winstrol-V Trifluomeprazine ...... Nortran Oxyphenonium...... Antrenyl ...... Stelazine Pancuronium...... Pavulon ...... Citanest Succinylcholine ...... Sucostrin, Quelin, etc. ...... Triperidol Pantoprazole...... Protonix ...... Mysoline ...... Carafate, Sulcrate ...... Vetame, Vesprin ...... Pavagen, etc. ...... Sufenta Trihexylphenidyl ...... Artane ...... Paral ...... Pronestyl Sulfasalazine ...... Azulfidine, Azaline Trimeprazine ...... Temaril ...... Paradione Sulfonamides and Potentiated Sulfonamides .... ...... Tridione ...... Haldrone Procaine Tribrissen, Septra, TMS (sulfamethazine, Trimethaphan ...... Arfonad ...... Eutonyl ...... ProAir /) ...... Surmontil ...... Paxil, Seroxat ...... Darbazine, Compazine Sulfondiethylmethane ...... PBZ Passion flower ...... Kemadrin ...... Actidil ...... Cylert ...... Sparine ...... Inofal ...... Phenergan ...... Clinoril Tubocurarine () ...... Metubin (including procaine penicillin G, sodium or ...... Rythmol ...... Aiglonyl, Sulpitil ...... Benvil, Nospan, etc. penicillin G, ampicillin) ...... Barnetil ...... Levatol Propantheline ...... Pro-Banthine ...... Imitrex Urethane ...... Cyperon Proparacaine ...... Ophthaine Tadalasil ...... Cialis Pentaerythritol tetranitrate ...... Duotrate Propentophylline ...... Karsivan Talbutal ...... Lotusate ...... Nirvanyl ...... Talwin ...... Largon ...... Diovan ...... Nembutal Propionylpromazine ...... Tranvet Telmisartin ...... Micardis ...... Levitra Pentoxyfylline ...... Trental, Vazofirin ...... Restoril ...... Metrazol, Nioric ...... Diprivan, Disoprivan ...... Alganex, etc. ...... Efflexor ...... Taxilan ...... Ravocaine ...... Hytrin ...... Accional, Veralipril Perfluorodecolin Propoxyphene ...... Brethine, Bricanyl ...... Calan, Isoptin Perfluorodecahydronophthalene ...... Inderal ...... Seldane, Triludan Vercuronium ...... Norcuron Perfluorooctylbromide ...... Benzedrex Testolactone ...... Teslac Vervain Perfluorotripropylamine ...... Dominal ...... Catatrol, Vivalan, etc. Perfluorocarbons ...... Ventaire ...... Nitoman ...... Delvinol ...... Alodept, etc. ...... Concordin, Triptil ...... Pontocaine ...... Optanox, Speda Perindopril ...... Biprel ...... Axeen, Centralgol ...... Coumadin, Coufarin ...... Hypnodin ...... Cenafed, Novafed (including oxytetracycline, doxycycline) ...... Rompun, Bay Va 1470 ...... Trilafon Pyridostigmine ...... Mestinon, Regonol (THC) Xylocaine ...... Phenurone Pyrilamine ...... Neoantergan, Equihist Tetrahydrozoline ...... Tyzine ...... Otrivin ...... Acalo, Alcamid, etc. Pyrimethamine Daraprim ...... Musaril, Myolastin ...... Narphen ...... Hybersulfan, Sonodor THC Yucca other than as a feed additive for the (PCP) ...... Sernylan Quazipam ...... Doral purpose of and at the levels of ...... Bontril, etc. ...... Seroquel reduction and intestinal health. ...... Nardelzine, Nardil Quinapril, metabolite Quinaprilat ...... Accupril ...... Aqualphyllin, etc. ...... Accolate (B-phenyl gamma aminobutyric acid) ...... Quinidex, Quinicardine ...... Kemithal ...... Sonata Phenicols Nuflor Rabeprazole ...... Aciphex ...... Ralgro (including , florfenicol) Racemethorphan ...... Surital ...... Zyflo Phenindione ...... Hedulin ...... Torecan ...... Geoden ...... Preludin Thiopental ...... Pentothal ...... Luminal ...... Raylean ...... Dartal ...... Zomig ...... Dibenzyline , metabolite Ramiprilat ...... Altace ...... Majeptil ...... Ambien, Stilnox Phenprocoumon ...... Liquamar ...... Zantac ...... Mellaril ...... Zomax ...... Milontin Rauwolfia Thiosalicylate ...... Zonegran ...... Iomamin Red poppy Thiothixene ...... Navane ...... Imovan ...... Regitine ...... Ultiva Thiphenamil ...... Trocinate ...... Lodopin ...... Butazolidin ...... Roxiam Thymosin Beta-4...... Vecta TB-1000 ...... Ciatyl, Cesordinol ...... Isophrin, Neo- ...... Serpasil Appendix B. Categories of Prohibited Substances

1. Anti-inflammatory (steroidal and/or non- cept for or similar acting progestagens 24. Respiratory steroidal) or other substances that have similar phar- in only, administered for the purpose of con- 25. Bronchodialators and products used for the macological actions trolling the estrus cycle. treatment of recurrent airway disease, mucolytics and 2. , anti-epilectic and antihypertensive 13. Pharmacological substances designed and mar- cough suppressants substances keted primarily for human use or use in other species 26. Muscle relaxants and for which alternative and generally accepted 3. such as selective reup- 27. Anti-coagulants take inhibitors, inhibitors and products are available for use in 28. substances antidepressants 14. Hypersensitizing or desensitizing agents 29. Evacuants and laxatives 4. Tranquilizers and including benzodiaz- 15. carriers 30. Topical agents, including ophthalmic, otic, der- epines and 16. mal and wound ointments or liniments that contain 5. 17. Antiprotozoal antimicrobials any prohibited substance 6. and opiod 18. 31. Any substance administered while competing 7. Amphetamines and other central nervous system 19. pump inhibitors administered at thera- in an endurance ride by nasogastric tube or syringe/ stimulants including cocaine and related psychotic drugs peutic levels and H2 antagonists needle. 8. Beta-blockers 20. Masking agents 32. Yucca administered for the purpose of and at 9. 21. Substances designed, marketed, and/or admin- the levels of ammonia reduction and intestinal health. 10. Anabolic and growth promoters istered to affect the behavior of an equine in a calm- Yucca administered for any other purpose or at levels to provide anti-inflammatory effect is prohibited. 11. Peptides and genetically recombinant substanc- ing (tranquilizing) or energizing (stimulating) manner. es such as erythropoietin, growth factor and This is to include herbal and/or natural products. 33. Bisphosphonates growth hormone 22. Local anaesthetics 34. Cannabidiol (CBD), tetrahydrocannabinol (THC) 12. Hormonal products (natural or synthesized) ex- 23. Sympathomimetic cardiac stimulants and all derivatives of the Sativa family

Appendix C. Allowed Substances

1. Vitamins (other than thiamine administered for the as altrenogest (Regumate) only in mares to control 12. Magnesium sulphate admistered for the purpose purpose of providing a calming/tranquilizing effect) estrus cycles. of electrolyte supplementation. Magnesium sulphate 2. Minerals 8. The following chondroprotective agents: glucos- administered for the purpose of and at the levels of providing a calming/tranquilizing effect is prohibited. 3. Electrolytes administered orally , chondroitin , polysulfated glycosami- noglycan, hyaluronate. Not to be administered by 13. (Prascend) – 1 mg/kg/day 4. Topical agents such as liniments and wound dressings needle/syringe while competing in an endurance ride that do not contain a prohibited substance 14. Vaccines and immunostimulants* (see Appendix B item 31). 5. Topically applied 15. administered at a preventative dose 9. Acid neutralizers including aluminum hydroxide no higher than 1 mg/kg/day 6. Ice and ice administered orally and/or topi- (Maalox, Neighlox) cally *There is insufficient information available to advise 10. Antihelmentics (dewormers) as to the timing of administration close to the time 7. Progesterone and similar acting progestagens such 11. Probiotics of competition.

Appendix D. Threshold Levels Urinary thresholds refer to the parent and/or metabolite. (S = stallions, G = , M = mares) In the absence of a listed threshold in Appendix D, AERC rule 13 will default to the Racing and Testing Consortium (RMTC) existing thresholds. Acepromazine...... 25 ng/ml...... urine Dipyrone...... 1,000 ng/ml...... plasma Naproxen...... 5,000 ng/ml...... plasma Albuterol...... 1 ng/mlu...... urine Estranediol...... 45 ng/ml (S)...... urine Oxyphenbutazone...... 1,000 ng/ml...... plasma Arsenic...... 200 ng/ml...... urine Firocoxib...... 20 ng/ml...... plasma Pentazocine...... 50 ng/ml...... urine Atropine...... 10 ng/ml...... urine Flumethasone...... 10 ng/ml...... urine Phenylbutazone...... 1,000 ng/ml...... plasma Benzocaine...... 50 ng/ml...... urine Flunixin (Banamine)...... 50 ng/ml...... plasma Prednisolone...... 1,000 ng/ml...... urine Boldenone...... 15 ng/ml (S)...... urine Furosemide...... 100 ng/ml...... plasma* Prednisone...... 100 ng/ml...... urine Hydrocortisone...... 1,000 ng/ml...... urine Procaine...... 50 ng/ml...... urine BZE (Benzoylecgonine)...... 50 ng/ml...... urine Imipramine...... 20 ng/ml...... plasma Promazine...... 25 ng/ml...... urine Betamethasone...... 60 ng/ml...... urine Isoflupredone...... 60 ng/ml...... urine Pyrilamine...... 50 ng/ml...... urine Bupivacaine...... 5 ng/ml...... urine Isoxsuprine...... 1,000 ng/ml...... urine Salicylates...... 750,000 ng/ml...... urine Butorphanol...... 10 ng/ml...... urine Ketoprofen...... 20 ng/ml...... plasma ...... 625,000 ng/ml...... urine Caffeine...... 100 ng/ml...... plasma Lidocaine...... 50ng/ml...... urine ...... 5,400 ng/ml...... plasma ...... 300 ng/ml...... urine Meclofenamic Acid...... 1,000 ng/ml...... plasma Terbutaline...... 10 ng/ml...... urine Clenbuterol...... 25 pg/ml...... plasma Mephenesin...... 200 ng/ml...... plasma Testosterone Dantrolene...... 100 ng/ml...... plasma Mepivacaine...... 10 ng/ml...... urine (epitestosterone)...... 20 ng/ml (G)...... urine Dexamethasone...... 60 ng/ml...... urine Methocarbamol...... 1,000 ng/ml...... plasma Testosterone...... 55 ng/ml (M)...... urine Diclofenac sodium...... 1.5 ng/ml...... plasma Methoxytramine...... 4,000 ng/ml...... urine Tetramisole...... 80 ng/ml...... plasma ...... 100 ng/ml...... urine Methylprednisolone...... 1,000 ng/ml...... urine Theobromine...... 2,000 ng/ml...... urine Dimethylsulfoxide (DMSO).... 15,000 ng/ml...... urine Morphine...... 50 ng/ml...... urine *The threshold for furosemide applies only if the urine ...... 1,000 ng/ml...... plasma specific gravity is less than 1.010. Appendix E. Known Detection Times for Substances Used Therapeutically in the Provided as a guideline only

Typical Dose/Route* for Elimination Detection Limit Drug______(Brand Name) Therapeutic Indication 1000 lb. (450kg) Horse Half-Life Source of Info. ______Tranquilizers/Sedatives acepromazine (Atravet®, PromAce®) Tranquilizer used for calming horses. Has no pain-relieving action 25 mg IV, IM; 30 mg IM 3 hr (IV), 36 hr (Canada), 120 hr (AAEP) ______50 mg Orally 6 hr (Orally) 72 hr () butorphanol______(Torbugesic®) with pain-relieving action, used frequently to treat colic in horses 5 mg IV 4 hr 72 hr (Canada) dantrolene______(Dantrium®) used in horses with myopathies (“tying-up”) 1 gram Orally 2 hr 36 hr (Canada) detomidine______(Dormosedan®) Sedative with pain-relieving action, used frequently to treat colic in horses 5 mg IV 1 hr 48 hr (Australia, FEI), 72 hr (Canada) guaifenesin______(Guailaxin®, Gecolate®) Muscle relaxant used in horses with myopathies (“tying-up”) 2 gram IV, Orally 1.5 hr 24 hr (Canada), 48 hr (Australia) methocarbamol______(Robaxin®) Muscle relaxant used in horses with myopathies (“tying-up”) 5 grams IV, Orally 1 hr 24 hr (Canada) romifidine______(Sedivet®) Sedative with pain-relieving action, used frequently to treat colic in horses 30 mg IV N/A** 48 hr (Australia) ______Anti-inflammatories/Pain Relievers aspirin Orally or pain-reliever in the horse. Sometimes used to treat periodic ophthalmia 11.7 grams Orally 1 hr 24 hr (Canada) ______(“moon blindness”), , and colic due to parasite damage. diclofenac sodium (Surpass) Applied topically as an anti-inflammatory agent Five-inch ribbon of 1% cream N/A** 72 hr (Idexx) applied twice daily for up to ______10 days dimethylsulfoxide (DMSO) Applied topically as an anti-inflammatory agent, given IV to treat myopathies 19.8 grams topically 9 hr 36 hr (Canada), 72 hr (AAEP) ______and increase urination 450 mg IV 96 hr (AAEP) firocoxib (Equioxx®) anti-inflammatory drug used to treat musculoskeletal pain 0.1 mg/kg/day 7 days (USEF) ______and inflammation flunixin (Banamine®) Nonsteroidal anti-inflammatory drug used to treat colic and 450 mg IV, Orally 1.6 hr 72 hr (Canada), 72 hr (Australia) ______musculoskeletal pain and inflammation 15 days (ELISA - AAEP), 144 hr (FEI) ketoprofen (Ketofen®, Anafen®) Nonsteroidal anti-inflammatory drug used to treat colic 1 gram IV 1.5 hr 48 hr (Canada), 72 hr (Australia, ______and musculoskeletal pain and inflammation AAEP), 96 hr (FEI) lidocaine______(Xylocaine®) Local used to block nerves 150 mg SC 1 hr 24 hr (Canada) meclofenamic acid (Arquel®) Nonsteroidal anti-inflammatory drug used to treat colic and 1 gram Orally 8 hr 48 hr (Canada), 72 hr (Australia) ______musculoskeletal pain and inflammation mepivicaine______(Carbocaine®) used to block nerves 300 mg SC, IA 3 hr 48 hr (Canada, Australia, FEI) naproxen (Equiproxen, Aleeve®) Nonsteroidal anti-inflammatory drug used to treat colic and 2 grams Orally 4 hr 120 hr (Canada) ______musculoskeletal pain and inflammation. phenylbutazone (“Bute”) Nonsteroidal anti-inflammatory drug used to treat colic and 3 grams, IV, Orally 11 hr 96 hr (Canada), 120 hr (Australia), musculoskeletal pain and inflammation 8.8 mg/kg twice daily on Day 1 168 hr (FEI) then 4.4 mg/kg twice daily ______on Days 2-11 procaine (Novocaine®) Local anesthetic used to block nerves 200 mg SC 2 hr IM 48 hr (Canada) ______1 hr SC procaine penicillin G Combined with penicillin to make the slowly absorbed from the 4 million Interational 10 hr 425 hr (Canada) ______injection site, to give it a long duration of antibacterial action Units IM ______Corticosteroids betamethasone______(Betasone®, Celestone®) Anti-inflammatory; allergic reactions 35 mg IM NA 24 hr (Canada), > 7 days (Australia) dexamethasone (Azium®) Anti-inflammatory; allergic reactions 25 mg IV, IM 4 hr 24 hr (Canada), 48 hr (Australia) ______10 mg Orally 144 hr (ELISA - AAEP) flumethasone______(Flucort®) Anti-inflammatory; allergic reactions 5 mg IV, IM NA 24 hr (Canada) isoflupredone______(Predef 2X®) Anti-inflammatory; allergic reactions. 24 mg IM NA 48 hr (Canada) methylprednisolone Anti-inflammatory; allergic reactions 200 mg IA, IM 9 days 96 hr (Canada), 222 hr (ELISA ______(Depo-Medrol®) - AAEP), > 45 days (Australia) prednisolone______Anti-inflammatory; allergic reactions. 150 mg IV 1.65 hr 24 hr (Canada) prednisone______Anti-inflammatory; allergic reactions 1 gram Orally 2 hr 24 hr (Canada) triamcinolone______(Vetalog®) Anti-inflammatory; allergic reactions 24 mg IM 2 hr 24 hr (Canada), 15 days (Australia) ______Miscellaneous Drugs aminophylline______Opens airways in horses with “heaves” 1.5 grams IV NA 96 hr (Canada) clenbuterol______(Ventipulmin®) Opens airways in horses with “heaves” 0.4 mg Orally NA 72 hr (Canada) dembrexine______(Sputolysin®) Expectorant for horses with “heaves” 150 mg Orally NA 72 hr (Canada) diphenhydramine______(Benadryl®) 500 mg Orally NA 48 hr (Canada, Australia) isoxuprine (Vasodilan®) Dilates blood vessels, used for treatment of navicular disease 300 mg Orally 3 hr 36 hr (Canada), weeks-months ______(ELISA - AAEP) omeprazole (Gastrogard®, Ulcergard®) Proton pump inhibitor used for the treatment and prevention of 1.1 mg/kg once daily (preventive) Orally N/A N/A ______esophagitis, erosive gastritis and gastric ulcers 4 mg/kg once daily (therapeutic) Orally N/A 24 hr (Merial) theophylline______Opens airways in horses with “heaves” 6 grams Orally NA >7 days (Australia) * IV - intravenous, IM - Intramuscular, SC - Subcutaneous, IA - Intra-articular (into the joint); ** No information available. Appendix F. Prohibited Treatments

1. Acupuncture, or any procedure involving the 5. Extracorporeal Shockwave therapy or similar 7. Administration of a local anesthetic, either insertion of a needle into the equine. device to produce a temporary or permanent topical, injectable or oral to any part of the horse 2. Osseous manipulation (chiropractic). analgesia. This would also include radiofrequency or any procedure that results in desensitization (RF) neurectomy. Extracorporeal shockwave of any part of the equine. 3. Any manipulative procedure using an ex- therapy is not permitted within 7 days of com- 8. Pinfiring/pinfreezing – visible active, open ternal device or instrument such as devices to petition. manipulate or stimulate acupressure or response lesions from such a procedure would prohibit a points, including but not limited to bioscans, laser 6. Any external magnetic field device or elec- horse from competition. lights or magnetic stimulation. tropulse generator device applied either over the 9. The use of substances or devices that cool entire body or specifically on pressure points. This below 0 degrees Celsius. 4. Any procedure involving the placement of a would include but not be limited to P3 machines. tube or other instrument into the equine (other The use of external magnetic field devices and 10. Equivibe and similar whole body vibration than the oral cavity using a dosing syringe, see electropulse generating devices on equines shall treatments. Appendix G item 4) for the purpose of administer- be allowed up to 72 hours prior to the pre-ride 11. Kinesiology taping. ing a substance or to stimulate a response. veterinary exam at AERC sanctioned rides, but use within 72 hours of the pre-ride veterinary exam and during a ride shall be prohibited.

Appendix G. Allowable Treatments

1. Massage, deep massage/acupressure using digital (hand/finger) pres- ice water. The use of devices or substances that cool below 0 degrees sure only. Celsius are prohibited. 2. The use of instruments commonly know as grooming instruments. 4. The oral administration of permitted substances by means of dosing 3. The use of ice boots and other means of applying ice/ice water topically. syringe. Can include the use of compression wraps as well as devices that circulate 5. Healed scars from pinfiring are allowed.

2019_DrugAppendix 1.5.5 Rev. 10/19