The Epidemiology of Heart Failure: the Framingham Study
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JACC Vol. 22. No. 4 (SupplementA) 6A October 1!893:6A43A PART II: NEW INSIGHTS INTO THE EPIDEMIOLOGY AND PATHOPHYSIOLOGY OF HEART FAILURE BertramPitt, MD, FACC, Chairrnaro EPIDEMIOLOGY The Epidemiology of Heart Failure: The Framingham Study KALON K. L. HO, MD,*? JOAN L. PINSKY, MA,* WILLIAM B. KANNEL, MD, FACC,g DANIEL LEVY, MD, FACC*tt Boston and Framingham, Massachusettsand Bethesda, Maryland - Congestive heart failure has become an incre&@ frequent women, whereas the age-adjustedprevoience of overt heart hilure reasonforhospiQla~durin~thc~2decpdosandderrly was 24/1,000in men and 25/1,000in women. Ikpite improved npresentsa~rlM!IdthplWblem.Dat?lfWltlWFkalUi@am tr&Wnts ror ischemil! heart d&ease and hypertension,the HeartStudy~tbattbeinddenceofamgestiveheartfailure age-adjustedincidence of heart failure has declined by only increaseswithageandisbigherinmenthaninwomen.Hyper- ll%/calendar decade in men and by 17Walendar decade in temionandcoromuyhemtdkasearethetwomostcommon women during a 40-year period of observation. In addition, conditionspndrrt& its onset. Diabetesmellitus and eleckowr- eve heart failure rem&s highly lethal, with a median diograpldcleftventrkukhypcWophyarealsnassociatedwitb s~~~eaf1.7yeus~menend3.2y~inwomenanda anhnzea&riskofkartfailm~.Duringthe1!J8Os,theanmud 5-yearsurvival rate of 25% in men and 38% in women. ~ustedincidenceofcongestiveheartfailureamongpersons (J Am CoUCar&l 1993$2~trpplemeatA].&&13A) aged 245 years was 7.2 cases/l,000in men and 4.7 cases/l,000in Although there is no consensus on the criteria required to (4-8) showed a steady increase in the number of hospital establish a diagnosis of congestive heart failure, it is clear admissions for congestive heart faihue during the last 2 that congestive heart failure represents a major health prob- decades. For example, the rate of hospital discharges with a lem. It has been estimated that congestive heart failure principal diagnosis of congestive heart faihue among Amer- afilicts nearly 4 million Americans, with soO,ooOnew cases icans 265 years increased from 7.5/1,0 in I%8 to l&3/ each year (I). Congestive heart failure was listed as the 1,Oo in 1989(4,7). principal cause for 37,400 deaths in 1988and is thought to In 1989,643,OOtlhospital discharges (2% of all discharges) have been a contributing cause of another 200,OtMdeaths carried a principal diagnosis of congestive heart failure (7. (2,3). Data from the National Hospital Discharge Survey An additional 4% (1.2 million) of all discharges carried a secondary diinosis of congestive heart failure. Amon; patients 265 years, congestive heart faihue was the principal From the *CharlesA. Dana Research Institute and the Harvard- diagnosis in 5% of those discharged and a secondary diag- ThomdiheLaboratory of the Departmentof Medicine,Cardiovascular Divi- nosis in another 10%. The rate of hospital stays with any sion, Beth IsraelHospital and HarvardMedical School, Boston,Massachu- discharge diagnosis of congestive heart faihue increases setts:t’fhe Ftamh&amHeart Study of the NationalHeart, Lung, and Blood Institute,Framingham, Massachusetts; #Division of Epidemiologyand Clin- dramatically with age, rising from 6.2/l ,008 in persons aged ical Applications,National Heart, Lung, and Blood Institnte, National 45 to 64 years to 47.411,OOtlin persons 265 years of age in Institutesof Health,Bethesda, Maryland and !lDepwtmentof Epidemiology 1989.Women were mnre frequently admitted to the hospital and Reventlve Medicine,University Hospital and Boston University School for congestive heart fake than were men. In 1989,the rate of Medicine,Boston. Massachusetts. This study was suppotted by Contract NOI-HC-38038and Grant ST32 HL 0737413from the NatlonalInstitutes of of hospital admissions with any discharge diagnosis of COD Health,Bethesda, Maryland. gestive heart failure was 6.811,Oogin men and 8/l,ooO in Manuscriptreceived September 13, 1992;revised manuscriptreceived February10.1993, accepted March 22,1993. women; the rate of hospital admission with a principal for W Daniel Levy, MD, FraminghamHeart diagnosis of congestive heart faihue was 2.5/1,00 in men Study, 5 ThurberStreet, Framin8ham. Massachusetts 01701. and 2.7/1,000in women (7). 81993 by the American College of Cardiology JACC Vol. 22, No. 4 (Supplement A) HO ET AL. 7A October 1993:6A-13A EPIDEMIOLOGY OF CONGESTIVE HEAAT FAILURE Methods Table1. Ckeriafor Congestive Heart Failure* In the Framingham Heart Study, we have had the oppor- Majorcriteria tunity to examine the incidence, prevalenceand prognosisof Paroxysmalnoctutnal dyspnea congestive heart failure during four decades of observation. Neck vein distension Our study group was composed of participants in the Rales Framingham Study and the Framingham Offspring Study. In Radiographic cardiomegaly @reasing heart size on chest X-ray film) 1948,5,209residents of Framingham, Massachusetts aged 28 Acute palmorary edema Third sound gallop to 62 years were enrolled in a prospective epidemiologic Increased central wxous pressure (>I6 cm water at the right atrium) study. The selection criteria and study design have been Ciitdation time 225 L reported elsewhere (9,lO). Members of this “original co- Hepatojugular retlax hort” have subsquently been evaluated at 2-year intervals Pulmonary edema, Gsceral congestion or cardiomegaly at autopsy with medical history, physical examination and laborator= Weighloss 24.5 kg in 5 days in respottse to treat- of CfiF tests. XII19?!, children of the original study participants and Minor Criteria spouses of these children, aged 6 to 70 years, were entered in Bilateral ankle edema the Framingham Offspring Study (11). Serial evaluations Nocturnal coug!~ were performed on members of the Framingham Offspring Dyspnea on ordinary exertion Study 8 and 12years after enrollment. The 5,209 members of Hepatomegaly the original cohort and the 5,135 members of the offspring Plearal elf&n cohort were eligible for inclusion in these analyszs. To avoid Decrease in vita) capacity by 33% from maximal value recorded Tachycardia (rate ~I20 beat&in) inclusion of overly high risk subjects in the offspring study, 881 members of the offspring cohort with only one natural The diagnosis of congestive heart failure (CKF) required that two major or one major and two mittor criteria be present concarrently. Minor aiterkt parent in the original cohort were excluded; such subjects were acceptable only if they could not be attriited to aaother medical were preferentially enrolled if that parent had a high risk condition. lipid profile or premarure cardiovascular disease. Cases of congestive heart failure diagnosed at the tirst Framingham Heart Study examination were included in estimates of heart nosed if voltage criteria for left ventricularhypertrophy were failure prevalence but excluded from estimates of heart fulfilled in an ECG exhibiting lateral ST segment depression failure incidence. or T wave flattening or inversion (13). At each examination, interim cardiovascular disease Using information obtained at Fram&ham Heart Study events were identified by medical history, physical exami- examinations and from hospital and physician record:;. a nation, 12-lead electrocardiogram (ECG) and review of diagnosis of congestive heart faihm: was established by the medical records. Hospital and physician records were ob- simultaneous presence of at least tro major or one major tained for participants who did not appear for an examina- and two minor criteria for congestive heart failure (Table 1). tion. All possible cardiovascuhu events were reviewed by a Minor criteria were acceptable only if they couid not be committee of three physicians, using established Framing- attributed to another medical condition (12-14). The same ham Heart Study protocols and definitions (12,13).Coronary criteria for congestive heart failure were used throughout the heart disease events included angina pectoris, coronary N-year follow-up period for these analyses. insufficiency (unstable angina) and myocardial infarction The incidence of congestive heart faihtre was estimated (12). A patient was considered to have preexisting valvular using the cross-sectional pooling method, with each 2-year heart disease if the examining physician noted a systolic interval between successive examinations treated as an murmur grade III/VI or louder, a diastolic murmur or a independent observation. Only individuals free of heart palpable thrill at any examination before the onset of heart failure were included in a Zyear observation pool. Subjects failure. Radiographic and echocardiographic data were not who failed to appear for an examination were assigned used in the diagnosis of coronary or valvular heart disease. “hypothetical” examination dates corresponding to their Elevated blood pressure was defined as a systolic blood biennial anniversary dates; only information concerning pressure 2160 mm Hg or a diastolic blood pressure interval cardiovascular disease events was attributed to 195 mm Hg on each of two successive determinations by a these hypothetical examinations. Ail of the observations physician during a clinic examination. Hypertension was were further classified by the calendar year of the examina- defined as the presence of either elevated blood pressure or tion and the age of the subject at the time of the visit. The ongoing pharmacologic treatment of a previously elevated relations between disease incidence and calendar yew, as blood pressure. Subjects with a fasting blood glucose level well as between dichotomous risk factor measures