Hiding in Plain Sight Treating Tobacco in NHS the Dependency

Total Page:16

File Type:pdf, Size:1020Kb

Hiding in Plain Sight Treating Tobacco in NHS the Dependency Hiding in plain sight sight plain in Hiding Treating tobacco dependency the NHS in tobacco Treating Hiding in plain sight Treating tobacco dependency in the NHS A report by the Tobacco Advisory Group of the Royal College of Physicians Royal College of Physicians 11 St Andrews Place Regent’s Park London NW1 4LE www.rcplondon.ac.uk June 2018 Hiding in plain sight Treating tobacco dependency in the NHS A report by the Tobacco Advisory Group of the Royal College of Physicians June 2018 Title page.indd 1 07/06/2018 15:12 Acknowledgments The Tobacco Advisory Group acknowledges the help of the UK Centre for Tobacco and Alcohol Studies (www.ukctas.net), which is funded by the UK Clinical Research Collaboration, for supporting much of the original research and literature reviews contained in this report; and thanks Priscilla Sharland for copyediting and Hannah Cole and the team in the Royal College of Physicians Publications Department for their work in producing the report. The Royal College of Physicians The Royal College of Physicians (RCP) plays a leading role in the delivery of high-quality patient care by setting standards of medical practice and promoting clinical excellence. The RCP provides physicians in over 30 medical specialties with education, training and support throughout their careers. As an independent charity representing 34,000 fellows and members worldwide, the RCP advises and works with government, patients, allied healthcare professionals and the public to improve health and healthcare. Citation for this document Royal College of Physicians. Hiding in plain sight: treating tobacco dependency in the NHS. London: RCP, 2018. Copyright All rights reserved. No part of this publication may be reproduced in any form (including photocopying or storing it in any medium by electronic means and whether or not transiently or incidentally to some other use of this publication) without the written permission of the copyright owner. Applications for the copyright owner’s written permission to reproduce any part of this publication should be addressed to the publisher. Copyright © Royal College of Physicians 2018 ISBN 978-1-86016-731-7 eISBN 978-1-86016-732-4 Royal College of Physicians 11 St Andrews Place Regent’s Park London NW1 4LE www.rcplondon.ac.uk Registered Charity No 210508 Typeset by Cambrian Typesetters, Camberley, Surrey Printed and bound in Great Britain by The Lavenham Press, Suffolk Contents Members of the Tobacco Advisory Group vii Contributors viii Foreword xii 1 Introduction 1 1.1 Tobacco smoking and health 1 1.2 Policies to prevent smoking in the UK 1 1.3 Services to help people to quit smoking 4 1.4 Objectives of this report 6 1.5 Summary 6 2 Associations between smoking and disease 9 2.1 Introduction 9 2.2 Smoking, mortality and life expectancy 9 2.3 Smoking and the risks of specific diseases and disorders 10 2.4 UK national cohort analysis of morbidity and mortality from smoking 31 2.5 Effects of smoking cessation after diagnosis on disease natural history or other outcomes 39 2.6 Summary 43 3 The financial cost of smoking to NHS secondary care 53 3.1 Introduction 53 3.2 Secondary care costs in the general adult population 54 3.3 Effects of maternal smoking during pregnancy 65 3.4 Passive smoking effects on child health 68 3.5 The cost of surgical complications due to smoking 70 3.6 Secondary care costs from smoking among people with mental disorders 72 3.7 Costs arising from smoking by NHS staff 82 3.8 Summary 93 © Royal College of Physicians 2018 iii Treating tobacco dependency in the NHS 4 Providing stop smoking services and treatment for tobacco dependency in the NHS 98 4.1 Introduction 98 4.2 Treatments for tobacco dependence and their effectiveness 98 4.3 Harm reduction 104 4.4 Smoking reduction 104 4.5 Novel approaches 105 4.6 Approaches and cautions with treatment of tobacco dependency in patient subgroups 107 4.7 Treating smokers who use the NHS 110 4.8 Cost-effectiveness of smoking cessation in relation to therapies used routinely to treat diseases caused by smoking 117 4.9 Summary 117 5 Commissioning stop smoking interventions in the NHS 126 5.1 Introduction 126 5.2 Expenditure on the NHS, public health and stop smoking services 126 5.3 Commissioning the health service and public health in England 127 5.4 Local government and stop smoking services in England 128 5.5 Commissioning in the NHS and stop smoking treatment in England 134 5.6 Integrating health and social care in England 139 5.7 Commissioning stop smoking services in the devolved nations 139 5.8 Approaches to stop smoking service model design and provision in other countries 143 5.9 A proposed new model for treating tobacco dependence in the NHS 144 5.10 Summary 145 6 Using data to drive improvement in treating tobacco dependence 150 6.1 Introduction 150 6.2 Data sources 151 6.3 Using data to improve the treatment of tobacco dependence in the NHS 165 6.4 Summary 169 7 Teaching and training in smoking cessation 174 7.1 Introduction 174 iv © Royal College of Physicians 2018 Contents 7.2 Undergraduate training of healthcare professionals 174 7.3 Postgraduate training of doctors via specialist medical colleges 178 7.4 Postgraduate training of other healthcare professionals 184 7.5 Training of ‘non-professionalised’ groups such as healthcare assistants 189 7.6 Awareness of smoking cessation interventions among practising healthcare professionals 189 7.7 Training by the National Centre for Smoking Cessation and Training 191 7.8 Summary 194 8 Smoke-free NHS estates 197 8.1 The NHS estate 197 8.2 Smoke-free legislation in the general population 197 8.3 Smoke-free policy in NHS settings 198 8.4 Why an NHS smoke-free estate is necessary 201 8.5 Implementing smoke-free estates in the NHS 202 8.6 The role of electronic cigarettes 208 8.7 Return on investment from introducing smoke-free estates 210 8.8 Conclusion 213 8.9 Summary 213 9 The ethics of health service engagement in the treatment of tobacco dependence 219 9.1 Autonomy and justice 219 9.2 Treating smokers in primary and secondary care 221 9.3 Opt-in and opt-out models 221 9.4 Efficient and effective use of resources 222 9.5 The health system 223 9.6 Correcting the system 223 9.7 Summary 224 10 Conclusions and summary 226 10.1 Introduction 226 10.2 Smoking, death and disease 226 10.3 The cost of smoking to NHS secondary care 227 10.4 How should tobacco dependency by treated in the NHS? 227 10.5 Commissioning stop smoking treatments 228 10.6 Using data to drive improvement 229 10.7 Teaching and training the NHS workforce about smoking cessation 229 © Royal College of Physicians 2018 v Treating tobacco dependency in the NHS 10.8 Keeping NHS grounds smoke free 230 10.9 The ethics of health service engagement in the treatment of tobacco dependence 230 10.10 Summary 231 vi © Royal College of Physicians 2018 Members of the Tobacco Advisory Group of the Royal College of Physicians Sanjay Agrawal Deborah Arnott Richard Ashcroft John Britton (chair) Tim Coleman Linda Cuthbertson Martin Dockrell Anna Gilmore Nick Hopkinson Martin Jarvis Jo Leonardi-Bee Ann McNeill Wendy Preston © Royal College of Physicians 2018 vii Contributors Sanjay Agrawal Consultant in respiratory & intensive care medicine, University Hospitals of Leicester NHS Trust Will Anderson Research consultant, Action on Smoking and Health Colin Angus Research fellow, University of Sheffield Richard Ashcroft Professor of bioethics, Queen Mary University of London Abtesam Askandar Postgraduate student, University of Nottingham Vadsala Baskaran Clinical research fellow, University of Nottingham Linda Bauld Professor of health policy, University of Stirling Alex Bobak General practitioner specialist in smoking cessation, Wandsworth Medical Centre, London Alan Brennan Professor of health economics and decision modelling, University of Sheffield Allison Brisbane Head of research information and policy, ASH Scotland John Britton Professor of epidemiology, University of Nottingham Tim Coleman Professor of primary care, University of Nottingham Elen de Lacy PhD student, Cardiff University Avril Devaney Director of nursing and therapies, Cheshire and Wirral Partnership NHS Foundation Trust Martin Dockrell Tobacco control lead, Public Health England Duncan Gillespie Research fellow, University of Sheffield Allan Gregory Tobacco control programme manager, Public Health England Nick Hopkinson Reader in respiratory medicine, Imperial College London Abby Hunter Research fellow, University of Nottingham viii © Royal College of Physicians 2018 Contributors John Hutchinson Consultant respiratory physician, Sherwood Forest Hospitals NHS Foundation Trust Matthew Jones Assistant professor in health economics, University of Nottingham Emma Knowles Head of policy and research, Healthcare Financial Management Association Tessa Langley Associate professor in health economics, University of Nottingham Hannah Lawrence Clinical research fellow, Nottingham University Hospitals NHS Trust Jo Leonardi-Bee Professor of medical statistics and epidemiology, University of Nottingham Wei Shen Lim Consultant respiratory physician, Nottingham University Hospitals NHS Trust Andy McEwen Chief executive, National Centre for Smoking Cessation and Training Tricia McKeever Professor of epidemiology and medical statistics, University of Nottingham Ann McNeill Professor of tobacco addiction, Kings College London Hayden McRobbie Professor in public health interventions, Queen Mary University of London Ann Morgan PhD student, Imperial College London Rachael Murray Associate professor
Recommended publications
  • Sílvia Vilares Conde
    Sílvia Vilares Conde FUNCTIONAL SIGNIFICANCE OF ADENOSINE IN CAROTID BODY CHEMOSENSORY ACTIVITY IN CONTROL AND CHRONICALLY HYPOXIC ANIMALS Lisboa, 2007 a Dissertation presented to obtain the PhD degree in “Ciências da Vida – Especialidade Farmacologia” at the Faculdade de Ciências Médicas, Universidade Nova de Lisboa and Biotecnología: Aplicaciones Biomédicas at the Facultad de Medicina, Universidad de Valladolid Supervised by Profs. Constancio Gonzalez, Emília Monteiro and Ana Obeso. b Realizado com o apoio da Fundação para a Ciência e Tecnologia, SFRH/BD/14178/2003 financiada pelo POCI 2010 no âmbito da Formação avançada para a Ciência, Medida IV.3. c To my mum and dad d This work: Originated the following publications: - Conde S.V., Obeso A., Vicario I., Rigual R., Rocher A. and Gonzalez C. (2006), Caffeine inhibition of rat carotid body chemoreceptors is mediated by A2A and A2B adenosine receptors, J. Neurochem., 98, 616-628. (Chapter 3) - Conde S.V. and Monteiro E.C. (2006), Activation of nicotinic ACh receptors with α4 subunits induces adenosine release at the rat carotid body, Br. J. Pharmacol., 147, 783-789. (Chapter 2) - Conde S.V. and Monteiro E.C. (2004), Hypoxia induces adenosine release from the rat carotid body, J. Neurochem., 89 (5), 1148-1156. (Chapter 1) - Conde S.V. and Monteiro E.C. (2003), Adenosine-acetylcholine interactions at the rat carotid body, In: “Chemoreception: From cellular signalling to functional plasticity”, JM Pequinot et al. (Eds), Klumer Academic Press London, 305-311. (Chapter 2) Won the following awards: - 1st Prize “De Castro-Heymans–Neil Award” awarded by ISAC (International Society for Arterial Chemoreception) to the best work presented by a Young Researcher each triennial ISAC Meeting, 2002 - Pfizer Honor Young Researcher Prize awarded by the Portuguese Society of Medical Sciences, 2002 e Functional significance of adenosine in carotid body chemoreception PhD thesis, Silvia Vilares Conde INDEX Page List of Figures and Tables………………………………………………………..
    [Show full text]
  • (19) United States (12) Patent Application Publication (10) Pub
    US 20130289061A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0289061 A1 Bhide et al. (43) Pub. Date: Oct. 31, 2013 (54) METHODS AND COMPOSITIONS TO Publication Classi?cation PREVENT ADDICTION (51) Int. Cl. (71) Applicant: The General Hospital Corporation, A61K 31/485 (2006-01) Boston’ MA (Us) A61K 31/4458 (2006.01) (52) U.S. Cl. (72) Inventors: Pradeep G. Bhide; Peabody, MA (US); CPC """"" " A61K31/485 (201301); ‘4161223011? Jmm‘“ Zhu’ Ansm’ MA. (Us); USPC ......... .. 514/282; 514/317; 514/654; 514/618; Thomas J. Spencer; Carhsle; MA (US); 514/279 Joseph Biederman; Brookline; MA (Us) (57) ABSTRACT Disclosed herein is a method of reducing or preventing the development of aversion to a CNS stimulant in a subject (21) App1_ NO_; 13/924,815 comprising; administering a therapeutic amount of the neu rological stimulant and administering an antagonist of the kappa opioid receptor; to thereby reduce or prevent the devel - . opment of aversion to the CNS stimulant in the subject. Also (22) Flled' Jun‘ 24’ 2013 disclosed is a method of reducing or preventing the develop ment of addiction to a CNS stimulant in a subj ect; comprising; _ _ administering the CNS stimulant and administering a mu Related U‘s‘ Apphcatlon Data opioid receptor antagonist to thereby reduce or prevent the (63) Continuation of application NO 13/389,959, ?led on development of addiction to the CNS stimulant in the subject. Apt 27’ 2012’ ?led as application NO_ PCT/US2010/ Also disclosed are pharmaceutical compositions comprising 045486 on Aug' 13 2010' a central nervous system stimulant and an opioid receptor ’ antagonist.
    [Show full text]
  • Studies on New Pharmacological Treatments for Alcohol Dependence - and the Importance of Objective Markers of Alcohol Consumption
    Studies on new pharmacological treatments for alcohol dependence - and the importance of objective markers of alcohol consumption Andrea de Bejczy 2016 Addiction Biology Unit Section of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology Sahlgrenska Academy at University of Gothenburg Sweden Cover illustration: by A. de Bejczy Inspired by Stan Lee’s “The Invincible Ironman. The empty shell”, Marvel Comics “…HIS VOICE IS HOARSE, HIS HAND TREMBLING AS HE REACHES FOR THE GLEAMING OBJECT THAT SEEMS BOTH WONDERFUL AND TERRIBLE TO HIM…” Studies on new pharmacological treatments for alcohol dependence ©Andrea de Bejczy [email protected] ISBN: 978-91-628-9788-8 (printed publication) ISBN: 978-91-628-9789-5 (e-publication) http://hdl.handle.net/2077/42349 Printed in Gothenburg, Sweden 2016 By INEKO ii La familia iii iv Studies on new pharmacological treatments for alcohol dependence - and the importance of objective markers of alcohol consumption Andrea de Bejczy Addiction Biology Unit Section of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology Sahlgrenska Academy at University of Gothenburg ABSTRACT This thesis will guide you through three randomized controlled trials (RCT) on three pharmacotherapies for alcohol dependence; the antidepressant drug mirtazapine, the smoking cessation drug varenicline and the glycine-uptake inhibitor Org 25935. The mirtazapine study was an investigator initiated single- center harm-reduction study with alcohol consumption measured by self-report in a diary as main outcome. The results indicated that mirtazapine reduced alcohol consumption in males with heredity for alcohol use disorder (AUD). The Org 25935 study was an international multi-center study with abstinence as treatment goal, main time to relapse and alcohol consumption was measured by self-report collected by the Time Line Follow Back method (TLFB).
    [Show full text]
  • Evidence-Based Guidelines for the Pharmacological Management of Substance Abuse, Harmful Use, Addictio
    444324 JOP0010.1177/0269881112444324Lingford-Hughes et al.Journal of Psychopharmacology 2012 BAP Guidelines BAP updated guidelines: evidence-based guidelines for the pharmacological management of substance abuse, Journal of Psychopharmacology 0(0) 1 –54 harmful use, addiction and comorbidity: © The Author(s) 2012 Reprints and permission: sagepub.co.uk/journalsPermissions.nav recommendations from BAP DOI: 10.1177/0269881112444324 jop.sagepub.com AR Lingford-Hughes1, S Welch2, L Peters3 and DJ Nutt 1 With expert reviewers (in alphabetical order): Ball D, Buntwal N, Chick J, Crome I, Daly C, Dar K, Day E, Duka T, Finch E, Law F, Marshall EJ, Munafo M, Myles J, Porter S, Raistrick D, Reed LJ, Reid A, Sell L, Sinclair J, Tyrer P, West R, Williams T, Winstock A Abstract The British Association for Psychopharmacology guidelines for the treatment of substance abuse, harmful use, addiction and comorbidity with psychiatric disorders primarily focus on their pharmacological management. They are based explicitly on the available evidence and presented as recommendations to aid clinical decision making for practitioners alongside a detailed review of the evidence. A consensus meeting, involving experts in the treatment of these disorders, reviewed key areas and considered the strength of the evidence and clinical implications. The guidelines were drawn up after feedback from participants. The guidelines primarily cover the pharmacological management of withdrawal, short- and long-term substitution, maintenance of abstinence and prevention of complications, where appropriate, for substance abuse or harmful use or addiction as well management in pregnancy, comorbidity with psychiatric disorders and in younger and older people. Keywords Substance misuse, addiction, guidelines, pharmacotherapy, comorbidity Introduction guidelines (e.g.
    [Show full text]
  • Neuronal Nicotinic Receptors
    NEURONAL NICOTINIC RECEPTORS Dr Christopher G V Sharples and preparations lend themselves to physiological and pharmacological investigations, and there followed a Professor Susan Wonnacott period of intense study of the properties of nAChR- mediating transmission at these sites. nAChRs at the Department of Biology and Biochemistry, muscle endplate and in sympathetic ganglia could be University of Bath, Bath BA2 7AY, UK distinguished by their respective preferences for C10 and C6 polymethylene bistrimethylammonium Susan Wonnacott is Professor of compounds, notably decamethonium and Neuroscience and Christopher Sharples is a hexamethonium,5 providing the first hint of diversity post-doctoral research officer within the among nAChRs. Department of Biology and Biochemistry at Biochemical approaches to elucidate the structure the University of Bath. Their research and function of the nAChR protein in the 1970’s were focuses on understanding the molecular and facilitated by the abundance of nicotinic synapses cellular events underlying the effects of akin to the muscle endplate, in electric organs of the acute and chronic nicotinic receptor electric ray,Torpedo , and eel, Electrophorus . High stimulation. This is with the goal of affinity snakea -toxins, principallyaa -bungarotoxin ( - Bgt), enabled the nAChR protein to be purified, and elucidating the structure, function and subsequently resolved into 4 different subunits regulation of neuronal nicotinic receptors. designateda ,bg , and d .6 An additional subunit, e , was subsequently identified in adult muscle. In the early 1980’s, these subunits were cloned and sequenced, The nicotinic acetylcholine receptor (nAChR) arguably and the era of the molecular analysis of the nAChR has the longest history of experimental study of any commenced.
    [Show full text]
  • The Effect of Sazetidine-A and Other Nicotinic Ligands on Nicotine Controlled Goal-Tracking in Female and Male Rats
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by University of Kentucky University of Kentucky UKnowledge Pharmaceutical Sciences Faculty Publications Pharmaceutical Sciences 2-2017 The Effect of Sazetidine-A and Other Nicotinic Ligands on Nicotine Controlled Goal-Tracking in Female and Male Rats S. Charntikov University of New Hampshire A. M. Falco University of Nebraska - Lincoln K. Fink University of Nebraska - Lincoln Linda P. Dwoskin University of Kentucky, [email protected] See next page for additional authors Right click to open a feedback form in a new tab to let us know how this document benefits ou.y Follow this and additional works at: https://uknowledge.uky.edu/ps_facpub Part of the Chemicals and Drugs Commons, Neuroscience and Neurobiology Commons, and the Pharmacy and Pharmaceutical Sciences Commons Authors S. Charntikov, A. M. Falco, K. Fink, Linda P. Dwoskin, and R. A. Bevins The Effect of Sazetidine-A and Other Nicotinic Ligands on Nicotine Controlled Goal- Tracking in Female and Male Rats Notes/Citation Information Published in Neuropharmacology, v. 113, part A, p. 354-366. © 2016 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC‐BY‐NC‐ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. The document available for download is the author's post-peer-review final draft of the article. Digital Object Identifier (DOI) https://doi.org/10.1016/j.neuropharm.2016.10.014 This article is available at UKnowledge: https://uknowledge.uky.edu/ps_facpub/128 HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author Neuropharmacology Manuscript Author .
    [Show full text]
  • Discriminative Stimulus Effects of Mecamylamine and Nicotine In
    Pharmacology, Biochemistry and Behavior 179 (2019) 27–33 Contents lists available at ScienceDirect Pharmacology, Biochemistry and Behavior journal homepage: www.elsevier.com/locate/pharmbiochembeh Discriminative stimulus effects of mecamylamine and nicotine in rhesus monkeys: Central and peripheral mechanisms T ⁎ Colin S. Cunningham, Megan J. Moerke, Lance R. McMahon Department of Pharmacodynamics, The University of Florida, Gainesville, FL, USA ABSTRACT Mecamylamine is a non-competitive nicotinic acetylcholine receptor (nAChR) antagonist that has been prescribed for hypertension and as an off-label smoking cessation aid. Here, we examined pharmacological mechanisms underlying the interoceptive effects (i.e., discriminative stimulus effects) of mecamylamine (5.6 mg/ kg s.c.) and compared the effects of nAChR antagonists in this discrimination assay to their capacity to block a nicotine discriminative stimulus (1.78 mg/kg s.c.) in rhesus monkeys. Central (pempidine) and peripherally restricted nAChR antagonists (pentolinium and chlorisondamine) dose-dependently substituted for the me- camylamine discriminative stimulus in the following rank order potency (pentolinium > pempidine > chlorisondamine > mecamylamine). In contrast, at equi- effective doses based on substitution for mecamylamine, only mecamylamine antagonized the discriminative stimulus effects of nicotine, i.e., pentolinium, chlor- isondamine, and pempidine did not. NMDA receptor antagonists produced dose-dependent substitution for mecamylamine with the following rank order potency (MK-801 > phencyclidine > ketamine). In contrast, behaviorally active doses of smoking cessation aids including nAChR agonists (nicotine, varenicline, and cytisine), the smoking cessation aid and antidepressant bupropion, and the benzodiazepine midazolam did not substitute for the discriminative stimulus effects of mecamylamine. These data suggest that peripheral nAChRs and NMDA receptors may contribute to the interoceptive stimulus effects produced by mecamylamine.
    [Show full text]
  • Gen 3-11-17 Pg.1.Indd 1 01/11/2017 17:35 COMPANY NEWS
    3November 2017 COMPANY NEWS 2 Aristo buys Amneal in Nordics and Spain 2 Eight EU authorities are Biocadisgearing up to market in Europe 3 Sandoz enjoys Rixathon 4 and Erelzi start deemed equivalent to US Akorn Grand Avenue facility received 483s 5 WBA is set to shut 600 stores in the US 6 CVS and Anthem ally for a 7 ight European Union (EU) national authorities have been recognised as “capable of PBM deal in US Econducting inspections of manufacturing facilities that meet US Food and Drug Finnish price reform exacts toll on Orion 8 Administration (FDA)requirements” by the US agency, as part of agoodmanufacturing practice (GMP) mutual recognition deal struck by European and US regulators earlier this MARKET NEWS 10 year. Authorities in Austria, Croatia, France, Italy, Malta, Spain, Sweden and the UK were IndustryurgesactiononSPC waiver in EU 10 recognised under the agreement, in what the FDA called an “important milestone”. US attorneys aiming to 11 “Beginning 1November, we will take the unprecedented and significant step forward in widen suit’s scope realising the key benefits of the mutualrecognition agreement with our European counterparts EMA continuityplannot business as usual 12 in that we will now rely on the inspectional data obtained by theseeight regulatory agencies,” Commission admitstoPUMA plan failure 13 stated DaraCorrigan, the FDA’s acting deputy commissioner for global regulatory operations US$54bn in savings fromUSbiosimilars 14 and policy. “The progress made so far puts us on track to meet our goal of completing all 28
    [Show full text]
  • Tabex®) and Psychosis
    1.1. Cytisine (Tabex®) and psychosis Introduction Tabex® has been licensed in Eastern Europe as an aid to smoking cessation for 40 years. In Netherlands, the drug Tabex® is not registered. The drug is produced in Bulgaria and can be illegal purchased via internet. The active substance in Tabex® is cytisine The molecular structure of cytisine has similarity to that of varenicline [1]. Varenicline was registered in the European Union in 2006 as a drug for smoking cessation therapy, under the brand name Champix®. It is available in the USA under the brand name Chantix® [2]. Varenicline was discovered through the synthesis of a series of compounds inspired by the natural product cytisine, which was previously known to have partial agonist activity at the 4 2 acetylcholine receptor ( 4 2 nAChR). Varenicline displays 30–60% of the in vivo efficacy of nicotine, and it also effectively blocked the in vivo response to nicotine [3]. Structural formulas nicotine varenicline cytisine Reports In March 2016 and December 2016 Lareb received 2 reports concerning patients who developed psychosis after use of Tabex® for smoking cessation. Case A (report number 217162): A Psychiatrist working at a mental health care facility reported about a female 41-50 years who developed a psychosis 34 days after start of Tabex® for smoking cessation. The product Tabex® was withdrawn. The patient was treated with haloperidol. At the time of reporting, the patient was recovering. Concomitant medication was not reported. The reporter mentions that stress around the time of the event could be an alternative or additional cause for the reaction.
    [Show full text]
  • Pharmacology
    STATE ESTABLISHMENT «DNIPROPETROVSK MEDICAL ACADEMY OF HEALTH MINISTRY OF UKRAINE» V.I. MAMCHUR, V.I. OPRYSHKO, А.А. NEFEDOV, A.E. LIEVYKH, E.V.KHOMIAK PHARMACOLOGY WORKBOOK FOR PRACTICAL CLASSES FOR FOREIGN STUDENTS STOMATOLOGY DEPARTMENT DNEPROPETROVSK - 2016 2 UDC: 378.180.6:61:615(075.5) Pharmacology. Workbook for practical classes for foreign stomatology students / V.Y. Mamchur, V.I. Opryshko, A.A. Nefedov. - Dnepropetrovsk, 2016. – 186 p. Reviewed by: N.I. Voloshchuk - MD, Professor of Pharmacology "Vinnitsa N.I. Pirogov National Medical University.‖ L.V. Savchenkova – Doctor of Medicine, Professor, Head of the Department of Clinical Pharmacology, State Establishment ―Lugansk state medical university‖ E.A. Podpletnyaya – Doctor of Pharmacy, Professor, Head of the Department of General and Clinical Pharmacy, State Establishment ―Dnipropetrovsk medical academy of Health Ministry of Ukraine‖ Approved and recommended for publication by the CMC of State Establishment ―Dnipropetrovsk medical academy of Health Ministry of Ukraine‖ (protocol №3 from 25.12.2012). The educational tutorial contains materials for practical classes and final module control on Pharmacology. The tutorial was prepared to improve self-learning of Pharmacology and optimization of practical classes. It contains questions for self-study for practical classes and final module control, prescription tasks, pharmacological terms that students must know in a particular topic, medical forms of main drugs, multiple choice questions (tests) for self- control, basic and additional references. This tutorial is also a student workbook that provides the entire scope of student’s work during Pharmacology course according to the credit-modular system. The tutorial was drawn up in accordance with the working program on Pharmacology approved by CMC of SE ―Dnipropetrovsk medical academy of Health Ministry of Ukraine‖ on the basis of the standard program on Pharmacology for stomatology students of III - IV levels of accreditation in the specialties Stomatology – 7.110105, Kiev 2011.
    [Show full text]
  • Use of Lobeline Compounds in the Treatment of Central Nervous System Diseases and Pathologies Peter A
    University of Kentucky UKnowledge Pharmaceutical Sciences Faculty Patents Pharmaceutical Sciences 7-11-2000 Use of Lobeline Compounds in the Treatment of Central Nervous System Diseases and Pathologies Peter A. Crooks University of Kentucky, [email protected] Linda P. Dwoskin University of Kentucky, [email protected] Right click to open a feedback form in a new tab to let us know how this document benefits oy u. Follow this and additional works at: https://uknowledge.uky.edu/ps_patents Part of the Pharmacy and Pharmaceutical Sciences Commons Recommended Citation Crooks, Peter A. and Dwoskin, Linda P., "Use of Lobeline Compounds in the Treatment of Central Nervous System Diseases and Pathologies" (2000). Pharmaceutical Sciences Faculty Patents. 94. https://uknowledge.uky.edu/ps_patents/94 This Patent is brought to you for free and open access by the Pharmaceutical Sciences at UKnowledge. It has been accepted for inclusion in Pharmaceutical Sciences Faculty Patents by an authorized administrator of UKnowledge. For more information, please contact [email protected]. US006087376A United States Patent [19] [11] Patent Number: 6,087,376 Crooks et al. [45] Date of Patent: *Jul. 11,2000 [54] USE OF LOBELINE COMPOUNDS IN THE Scherman, D., “DihydrotetrabenaZine binding and monoam TREATMENT OF CENTRAL NERVOUS ine uptake in mouse brain regions,” J. Neurochem. 47, SYSTEM DISEASES AND PATHOLOGIES 331—339 (1986). Scherman, D. et al., “The regionaliZation of [3H]dihydrotet [75] Inventors: Peter A. Crooks; Linda P. DWoskin, rabenaZine binding sites in the mouse brain and its relation both of Lexington, Ky. ship to the distribution of monoamines and their metabo lites,” Brain Res.
    [Show full text]
  • New Pharmacological Agents to Aid Smoking Cessation and Tobacco Harm Reduction: What Has Been Investigated and What Is
    New Pharmacological Agents to Aid Smoking Cessation and Tobacco Harm Reduction: What has been Investigated and What is in the Pipeline? Emma Beard1,2, Lion Shahab1, Damian M. Cummings3, Susan Michie2 & Robert West1 1 University College London, Department of Epidemiology and Public Health, London, UK 2 University College London, Department of Clinical, Educational and Health Psychology, London, UK 3 University college London, Department of Neuroscience, Physiology & Pharmacology, London, UK Running header: New Agents for smoking cessation and tobacco harm reduction Word count: 12,739 Journal: Invited by CNS drugs Correspondence: Emma Beard, Cancer Research UK Health Behaviour Research Centre, University College London, WC1E 6BP, UK. Email: [email protected]. Tel: 0203 108 3179 Abstract A wide range of support is available to help smokers to quit and aid attempts at harm reduction, including three first-line smoking cessation medications: nicotine replacement therapy, varenicline and bupropion. Despite the efficacy of these, there is a continual need to diversify the range of medications so that the needs of tobacco users are met. This paper compares the first-line smoking cessation medications to: 1) two variants of these existing products: new galenic formulations of varenicline and novel nicotine delivery devices; and 2) twenty-four alternative products: cytisine (novel outside of central and eastern Europe), nortriptyline, other tricyclic antidepressants, electronic cigarettes, clonidine (an anxiolytic), other anxiolytics (e.g. buspirone), selective 5-hydroxytryptamine (5-HT) reuptake inhibitors, supplements (e.g. St John’s wort), silver acetate, nicobrevin, modafinil, venlafaxine, monoamine oxidase inhibitors (MAOI), opioid antagonist, nicotinic acetylcholine receptors (nAChR) antagonists, glucose tablets, selective cannabinoid type 1 receptor antagonists, nicotine vaccines, drugs that affect gamma-aminobutyric acid (GABA) transmission, drugs that affect N-methyl-D-aspartate receptors (NMDA), dopamine agonists (e.g.
    [Show full text]