University of Groningen

Replicative and Death Linskens, Maarten H.K.; Harley, Calvin B.; West, Michael D.; Campisi, Judith; Hayflick, Leonard Published in: Science

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Publication date: 1995

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA): Linskens, M. H. K., Harley, C. B., West, M. D., Campisi, J., & Hayflick, L. (1995). Replicative Senescence and Cell Death. Science, 267, 17.

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Download date: 29-09-2021 ReplicativeSenescence and Leonard Hayflick Nathan (j'oodman Cell Death University of California, San Francisco, Whitehead Institute, and Post Office Box 89, Whitehead Institute/MlT Center We read with great interest the excellent Sea Ranch, CA 95497, USA for Genome Research, Research News article "Chromosome ends Cambndge Center, catch fire" by Jean Marx (16 Sept., p. Cambndge, MA 02142, USA 1656), which chronicles the major discov- Eric S. Lander eries that have been made leading to our Software Availability Department of Biology, present understanding of the role of telo- Massachusetts lnstitute of Technology, and meres in replicative senescence and immor- Box 2, the "mouse genome resources and Director, tality. However, we would like to point out informatics" section (17 June, p. 1730) in Whitehead InstitutelMlT Center that replicative senescence is not synony- the article "Forward and reverse genetic for Genome Research, mous with cell death and that a mechanism approaches to behavior in the mouse" by J. Cambndge, MA 02139, USA for senescence is not necessarily the activa- S. Takahashi et al. (17 June, p. 1724), Rachel Oberai-Soltz tion of genes that trigger cell death. describes how to obtain the MAP- Digital Equipment Corporation, Cultured senescent cells do not die im- MAKER/EXP and MAPMAKERIQTL 50 Nagog Park, AK02-2/D8, mediately. After cessation of division, a ma- software developed at the Whitehead In- Acton, MA 01720, USA ,ioritv , of them remain viable and metaboli- stitute. It is not mentioned that both pro- cally active for long periods in , grams are available from the Whitehead and probably in vivo as well. To our knowl- Institute for the Digital Equipment Cor- Corrections and Clarifications edge, no one has observed programmed cell poration's Alpha systems in DEC OSF/l. The list of authors of the report "The Clemen- death during senescence. For MAPMAKER/EXP and MAPMAKER/ tine mission to the Moon" by S. Nozette et al. Maarten H. K. Linskens QTL distribution for Alpha AXP in DEC (16 Dec., p. 1835) should not have included Calvin B. Harley OSF/l, contact MAPMAKER, c/o Eric R. A. S~mpson. Michael D. West Lander at the address below (Fax: 617-258- , 6505; Intemet: [email protected]. In the authors' note for the report "Suppression 200 Constitution Drive, edu). For information on software of hyphal formation in Candida albicans by mutation of a STEl2 homolog" by Haoping Menlo Park, CA 94025, USA applications available for Alpha, contact Liu et al. (9 Dec., p. 1723), the affiliation for Judith Campisi Rachel Oberai-Soltz at Digital Equipment G. R. Fink should have been the Whitehead Lawrence Berkeley Laboratory, Corporation at the address below (Phone: Institute for Biomedical Research and the University of California, 508-264-7844; Intemet: roberai@akocoa. Massachusetts Institute of Technology, Cam- Berkeley, CA 94720, USA enet.dec.com). bridge, MA 02142, USA.

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