April 13, 2021 u vol. 118 u no. 15

From the Cover

e2104068118 Misinformation in the public sphere e2020020118 Parrot rearing in pre-Columbian Chile e1917487118 Nutritional benefits of diverse seafood diet e2005483118 CD47 overexpression and brain overgrowth

Contents

THIS WEEK IN PNAS—This week’s research highlights eiti1521118 In This Issue

Cover image: Pictured is an abstract NEWS FEATURE—An in-depth look at trending science issues rendition of a network representing effective science communication. e2105018118 How “forever chemicals” might impair the immune system The Arthur M. Sackler Colloquium on Carolyn Beans Advancing the Science and Practice of Science Communication: Misinformation About Science in the Public Sphere QNAS—Interviews with leading scientific researchers and newsmakers explores factors that influence belief e2104638118 QnAs with David Bercovici of scientific misinformation circulated Farooq Ahmed via public communication channels, See Inaugural Article, e2011247118, in vol. 118, issue 4 including legacy and social media. Together, the collection of articles in the Colloquium explores what is known PROFILE—The life and work of NAS members about the spread and impact of scientific e2104246118 Profile of Howard Y. Chang misinformation as well as the evidence Farooq Ahmed from social science for when and how See Inaugural Article, e2023070118, in vol. 118, issue 15 interventions are likely to be successful. See the Introduction to the Colloquium by Dietram A. Scheufele, Andrew J. COMMENTARIES Hoffman, Liz Neeley, and Czerne M. e2103700118 Prioritizing COVID-19 vaccination by age Reid, e2104068118. Image credit: the Marcia C. Castro and Burton Singer National Academies of Sciences, See companion article, e2026322118, in vol. 118, issue 11 Engineering, and Medicine, https:// e2102944118 The epigenetic regulation of adipose tissue plasticity doi.org/10.17226/23674. Shingo Kajimura See companion article, e2021073118, in vol. 118, issue 11

PERSPECTIVE e1921854118 Potential ecological impacts of climate intervention by reflecting sunlight to cool Earth Phoebe L. Zarnetske, Jessica Gurevitch, Janet Franklin, Peter M. Groffman, Cheryl S. Harrison, Jessica J. Hellmann, Forrest M. Hoffman, Shan Kothari, Alan Robock, Simone Tilmes, Daniele Visioni, Jin Wu, Lili Xia, and Cheng-En Yang

LETTERS e2023648118 His345 mutant of angiotensin-converting enzyme 2 (ACE2) remains enzymatically active against angiotensin II Pan Liu, Xinfang Xie, Li Gao, and Jing Jin

Free online through the PNAS open access option. PNAS u April 13, 2021 u vol. 118 u no. 15 u iii–viii Downloaded by guest on September 26, 2021 e2024450118 Reply to Liu et al.: Specific mutations matter in e2021852118 Functional connectome fingerprinting using specificity and catalysis in ACE2 shallow feedforward neural networks Jeff Glasgow, Anum Glasgow, Tanja Kortemme, Gokce Sarar, Bhaskar Rao, and Thomas Liu and James A. Wells e2026641118 An incorrect wetness-based correction PHYSICAL SCIENCES method for deuterium offset Ying Zhao APPLIED MATHEMATICS e2102585118 Reply to Zhao: The demonstrated magnitude e2020397118 Inference of dynamic systems from noisy and of artifact during stem water extraction signals sparse data via manifold-constrained a clear need for deuterium correction Gaussian processes Xin Song, Yongle Chen, Brent R. Helliker, Xianhui Tang, Shihao Yang, Samuel W. K. Wong, and S. C. Kou Fang Li, and Youping Zhou e2020424118 Growth, death, and resource competition in sessile organisms INAUGURAL ARTICLE Edward D. Lee, Christopher P. Kempes, e2023070118 BABEL enables cross-modality translation and Geoffrey B. West between multiomic profiles at single- cell resolution APPLIED PHYSICAL SCIENCES Kevin E. Wu, Kathryn E. Yost, Howard Y. Chang, e2023623118 Hyperspectral interference tomography and James Zou of nacre See Profile Article, e2104246118, in vol. 118, issue 15 Jad Salman, Cayla A. Stifler, Alireza Shahsafi, Chang-Yu Sun, Stephen C. Weibel, Michel Frising, Bryan E. ARTHUR M. SACKLER COLLOQUIUM ON ADVANCING Rubio-Perez, Yuzhe Xiao, Christopher Draves, THE SCIENCE AND PRACTICE OF SCIENCE Raymond A. Wambold, Zhaoning Yu, Daniel C. Bradley, Gabor Kemeny, Pupa U. P. A. Gilbert, COMMUNICATION: MISINFORMATION ABOUT and Mikhail A. Kats SCIENCE IN THE PUBLIC SPHERE e2022887118 Establishment of heterochromatin in INTRODUCTION domain-size-dependent bursts e2104068118 Misinformation about science in the Jan Fabio Nickels, Ashleigh Katrine Edwards, Sebastian Jespersen Charlton, Amanda Møller public sphere Mortensen, Sif Christine Lykke Hougaard, Ala Dietram A. Scheufele, Andrew J. Hoffman, Liz Neeley, Trusina, Kim Sneppen, and Genevie`ve Thon and Czerne M. Reid COLLOQUIUM PAPERS BIOPHYSICS AND COMPUTATIONAL BIOLOGY e1912437117 Misinformation and public opinion of science e2021263118 Accurate modeling of DNA conformational and health: Approaches, findings, flexibility by a multivariate Ising model and future directions Korbinian Liebl and Martin Zacharias Michael A. Cacciatore e2024608118 Mechanosensitive remodeling of the bacterial e1912443118 Measuring the news and its impact flagellar motor is independent of direction on democracy of rotation Duncan J. Watts, David M. Rothschild, Navish Wadhwa, Yuhai Tu, and Howard C. Berg and Markus Mobius e2024651118 Structural basis for Clostridium perfringens e1912444117 Misinformation in and about science enterotoxin targeting of claudins at tight Jevin D. West and Carl T. Bergstrom junctions in mammalian gut e1912440117 Why the backfire effect does not explain Alex J. Vecchio, Sewwandi S. Rathnayake, the durability of political misperceptions and Robert M. Stroud Brendan Nyhan e1914085117 The narrative truth about scientific misinformation CHEMISTRY Michael F. Dahlstrom e2022379118 Direct coordination of pterin to FeII enables e1912441117 A scientific theory of gist communication and neurotransmitter biosynthesis in thepterin- misinformation resistance, with implications dependent hydroxylases for health, education, and policy Shyam R. Iyer, Kasper D. Tidemand, Jeffrey T. Babicz Jr, Ariel B. Jacobs, Leland B. Gee, Lærke T. Haahr, Valerie F. Reyna Yoshitaka Yoda, Masayuki Kurokuzu, Shinji Kitao, e2002484118 Emotion and humor as misinformation Makina Saito, Makoto Seto, Hans E. M. Christensen, antidotes Gu¨nther H. J. Peters, and Edward I. Solomon Sara K. Yeo and Meaghan McKasy e2023867118 Size dependence of hydrophobic hydration at e1912436117 (Mis)informed about what? What it means to electrified gold/water interfaces be a science-literate citizen in a digital world Alessandra Serva, Mathieu Salanne, Martina Havenith, Emily L. Howell and Dominique Brossard and Simone Pezzotti

BRIEF REPORTS COMPUTER SCIENCES e2103090118 Melanocortin 3 receptor-expressing neurons e2016239118 Biological structure and function emerge from in the ventromedial hypothalamus promote scaling unsupervised learning to 250 million glucose disposal protein sequences Amy K. Sutton, Paulette B. Goforth, Ian E. Gonzalez, Alexander Rives, Joshua Meier, Tom Sercu, Siddharth James Dell’Orco, Hongjuan Pei, Martin G. Myers Jr, Goyal, Zeming Lin, Jason Liu, Demi Guo, Myle Ott, and David P. Olson C. Lawrence Zitnick, Jerry Ma, and Rob Fergus

iv u www.pnas.org Contents Downloaded by guest on September 26, 2021 EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES e2022886118 Addressing partial identification in climate e2018211118 The contributions of individual countries and modeling and policy analysis regions to the global radiative forcing Charles F. Manski, Alan H. Sanstad, Bo Fu, Bengang Li, Thomas Gasser, Shu Tao, Philippe and Stephen J. DeCanio Ciais, Shilong Piao, Yves Balkanski, Wei Li, Tianya Yin, e2025368118 Earnings growth and the wealth distribution Luchao Han, Yunman Han, Siyuan Peng, and Jing Xu Thomas J. Sargent, Neng Wang, and Jinqiang Yang e2019208118 Dead clades walking are a pervasive macroevolutionary pattern POLITICAL SCIENCES B. Davis Barnes, Judith A. Sclafani, and Andrew Zaffos e1912440117 Why the backfire effect does not explain ENGINEERING the durability of political misperceptions e2021684118 Mechanics of two filaments in tight Brendan Nyhan orthogonal contact e2019706118 Evaluating the effects of shelter-in-place Paul Grandgeorge, Changyeob Baek, Harmeet Singh, Paul Johanns, Tomohiko G. Sano, Alastair Flynn, policies during the COVID-19 pandemic John H. Maddocks, and Pedro M. Reis Christopher R. Berry, Anthony Fowler, Tamara Glazer, Samantha Handel-Meyer, and Alec MacMillen e2021077118 Human hand as a powerless and multiplexed infrared light source for information decryption and complex signal generation PSYCHOLOGICAL AND COGNITIVE SCIENCES Shun An, Wen Shang, Modi Jiang, Yini Luo, Benwei Fu, e1912441117 A scientific theory of gist communication and Chengyi Song, Peng Tao, and Tao Deng misinformation resistance, with implications e2022339118 Time–connectivity superposition and the for health, education, and policy gel/glass duality of weak colloidal gels Valerie F. Reyna Bavand Keshavarz, Donatien Gomes Rodrigues, e2017543118 Disentangling perceptual awareness from Jean-Baptiste Champenois, Matthew G. Frith, Jan nonconscious processing in rhesus Ilavsky, Michela Geri, Thibaut Divoux, Gareth H. monkeys (Macaca mulatta) McKinley, and Arnaud Poulesquen Moshe Shay Ben-Haim, Olga Dal Monte, Nicholas A. MATHEMATICS Fagan, Yarrow Dunham, Ran R. Hassin, Steve W. C. e2023227118 Fourier uniqueness in even dimensions Chang, and Laurie R. Santos Andrew Bakan, Haakan Hedenmalm, Alfonso Montes- Rodrı´guez, Danylo Radchenko, and Maryna Viazovska SOCIAL SCIENCES PHYSICS e1912437117 Misinformation and public opinion of science e2024362118 Topological defects produce kinks in and health: Approaches, findings, biopolymer filament bundles and future directions Valentin M. Slepukhin, Maximilian J. Grill, Qingda Hu, Michael A. Cacciatore Elliot L. Botvinick, Wolfgang A. Wall, and Alex J. Levine e1912443118 Measuring the news and its impact STATISTICS on democracy e2014602118 Confidence intervals for policy evaluation in Duncan J. Watts, David M. Rothschild, adaptive experiments and Markus Mobius Vitor Hadad, David A. Hirshberg, Ruohan Zhan, e1912444117 Misinformation in and about science Stefan Wager, and Susan Athey Jevin D. West and Carl T. Bergstrom e2101344118 Density estimation using deep generative e1914085117 The narrative truth about scientific misinformation neural networks Michael F. Dahlstrom Qiao Liu, Jiaze Xu, Rui Jiang, and Wing Hung Wong e2002484118 Emotion and humor as misinformation SUSTAINABILITY SCIENCE antidotes e2022886118 Addressing partial identification in climate Sara K. Yeo and Meaghan McKasy modeling and policy analysis e1912436117 (Mis)informed about what? What it means to Charles F. Manski, Alan H. Sanstad, be a science-literate citizen in a digital world and Stephen J. DeCanio Emily L. Howell and Dominique Brossard SOCIAL SCIENCES e2025324118 Short-term forecasts of expected deaths Silvia Rizzi and James W. Vaupel ANTHROPOLOGY e2020020118 Pre-Columbian transregional captive rearing SUSTAINABILITY SCIENCE of Amazonian parrots in the Atacama Desert Jose´ M. Capriles, Calogero M. Santoro, Richard J. e2024399118 Provisional COVID-19 infrastructure induces George, Eliana Flores Bedregal, Douglas J. Kennett, large, rapid increases in cycling Logan Kistler, and Francisco Rothhammer Sebastian Kraus and Nicolas Koch e2020430118 Combat stress in a small-scale society suggests divergent evolutionary roots for posttraumatic stress disorder symptoms BIOLOGICAL SCIENCES Matthew R. Zefferman and Sarah Mathew ANTHROPOLOGY ECONOMIC SCIENCES e2020020118 Pre-Columbian transregional captive rearing e2014602118 Confidence intervals for policy evaluation in of Amazonian parrots in the Atacama Desert adaptive experiments Jose´ M. Capriles, Calogero M. Santoro, Richard J. Vitor Hadad, David A. Hirshberg, Ruohan Zhan, George, Eliana Flores Bedregal, Douglas J. Kennett, Stefan Wager, and Susan Athey Logan Kistler, and Francisco Rothhammer

Contents PNAS u April 13, 2021 u vol. 118 u no. 15 u v Downloaded by guest on September 26, 2021 APPLIED BIOLOGICAL SCIENCES e2026804118 Capture and metabolomic analysis of the e2018627118 Modular complement assemblies for human endometrial epithelial mitigating inflammatory conditions organoid secretome Kelly M. Hainline, Lucas S. Shores, Nicole L. Votaw, Constantine A. Simintiras, Pramod Dhakal, Chaman Zachary J. Bernstein, Sean H. Kelly, Chelsea N. Fries, Ranjit, Harriet C. Fitzgerald, Ahmed Z. Balboula, Marisha S. Madhira, Caslin A. Gilroy, Ashutosh Chilkoti, and Thomas E. Spencer and Joel H. Collier e2021210118 Cytokinetic abscission is part of the e2002324118 Ranking the risk of animal-to-human spillover midblastula transition in early for newly discovered viruses zebrafish embryogenesis Zoe¨ L. Grange, Tracey Goldstein, Christine K. Shai Adar-Levor, Dikla Nachmias, Shani T. Gal-Oz, Johnson, Simon Anthony, Kirsten Gilardi, Peter Yarden M. Jahn, Nadine Peyrieras, Assaf Zaritsky, Daszak, Kevin J. Olival, Tammie O’Rourke, Suzan Ramon Y. Birnbaum, and Natalie Elia Murray, Sarah H. Olson, Eri Togami, Gema Vidal, e2021658118 Myristoylation alone is sufficient for PKA Expert Panel, PREDICT Consortium, catalytic subunits to associate with and Jonna A. K. Mazet the plasma membrane to regulate BIOCHEMISTRY neuronal functions Wei-Hong Xiong, Maozhen Qin, and Haining Zhong e2022379118 Direct coordination of pterin to FeII enables neurotransmitter biosynthesis in the pterin- e2018505118 Establishment of bovine expanded potential dependent hydroxylases stem cells Shyam R. Iyer, Kasper D. Tidemand, Jeffrey T. Babicz Lixia Zhao, Xuefei Gao, Yuxuan Zheng, Zixin Wang, Jr, Ariel B. Jacobs, Leland B. Gee, Lærke T. Haahr, Gaoping Zhao, Jie Ren, Jia Zhang, Jian Wu, Baojiang Yoshitaka Yoda, Masayuki Kurokuzu, Shinji Kitao, Wu, Yanglin Chen, Wei Sun, Yunxia Li, Jie Su, Yulin Makina Saito, Makoto Seto, Hans E. M. Christensen, Ding, Yuan Gao, Moning Liu, Xiaochun Bai, Gu¨nther H. J. Peters, and Edward I. Solomon Liangzhong Sun, Guifang Cao, Fuchou Tang, Siqin Bao, Pentao Liu, and Xihe Li e2022308118 Architecture of the mycobacterial succinate dehydrogenase with a membrane- e2009329118 The pentatricopeptide repeat protein Rmd9 embedded Rieske FeS cluster recognizes the dodecameric element in the ′ Xiaoting Zhou, Yan Gao, Weiwei Wang, Xiaolin Yang, 3 -UTRs of yeast mitochondrial mRNAs Xiuna Yang, Fengjiang Liu, Yanting Tang, Sin Man Lam, Hauke S. Hillen, Dmitriy A. Markov, Ireneusz D. Wojtas, Guanghou Shui, Lu Yu, Changlin Tian, Luke W. Guddat, Katharina B. Hofmann, Michael Lidschreiber, Quan Wang, Zihe Rao, and Hongri Gong Andrew T. Cowan, Julia L. Jones, Dmitry Temiakov, Patrick Cramer, and Michael Anikin BIOPHYSICS AND COMPUTATIONAL BIOLOGY e2021263118 Accurate modeling of DNA conformational flexibility by a multivariate Ising model DEVELOPMENTAL BIOLOGY Korbinian Liebl and Martin Zacharias e2023623118 Hyperspectral interference tomography e2024362118 Topological defects produce kinks in of nacre biopolymer filament bundles Jad Salman, Cayla A. Stifler, Alireza Shahsafi, Chang-Yu Sun, Stephen C. Weibel, Michel Frising, Bryan E. Valentin M. Slepukhin, Maximilian J. Grill, Qingda Hu, Rubio-Perez, Yuzhe Xiao, Christopher Draves, Elliot L. Botvinick, Wolfgang A. Wall, and Alex J. Levine Raymond A. Wambold, Zhaoning Yu, Daniel C. e2024608118 Mechanosensitive remodeling of the bacterial Bradley, Gabor Kemeny, Pupa U. P. A. Gilbert, flagellar motor is independent of direction and Mikhail A. Kats of rotation e2101080118 Riboflavin instability is a key factor underlying Navish Wadhwa, Yuhai Tu, and Howard C. Berg the requirement of a gut microbiota for e2016239118 Biological structure and function emerge from mosquito development scaling unsupervised learning to 250 million Yin Wang, Jai Hoon Eum, Ruby E. Harrison, Luca protein sequences Valzania, Xiushuai Yang, Jena A. Johnson, Derek T. Alexander Rives, Joshua Meier, Tom Sercu, Siddharth Huck, Mark R. Brown, and Michael R. Strand Goyal, Zeming Lin, Jason Liu, Demi Guo, Myle Ott, e2017176118 The giant axolotl genome uncovers the C. Lawrence Zitnick, Jerry Ma, and Rob Fergus evolution, scaling, and transcriptional e2019053118 Learning the molecular grammar of protein control of complex gene loci condensates from sequence determinants Siegfried Schloissnig, Akane Kawaguchi, Sergej and embeddings Nowoshilow, Francisco Falcon, Leo Otsuki, Pietro Kadi L. Saar, Alexey S. Morgunov, Runzhang Qi, Tardivo, Nataliya Timoshevskaya, Melissa C. Keinath, William E. Arter, Georg Krainer, Alpha A. Lee, Jeramiah James Smith, S. Randal Voss, and Tuomas P. J. Knowles and Elly M. Tanaka e2019630118 Cotranscriptional R-loop formation by Mfd e2017952118 BMP heterodimers signal via distinct type I involves topological partitioning of DNA receptor class functions James R. Portman, Gwendolyn M. Brouwer, Jack Benjamin Tajer, James A. Dutko, Shawn C. Little, Bollins, Nigel J. Savery, and Terence R. Strick and Mary C. Mullins

CELL BIOLOGY e2024651118 Structural basis for Clostridium perfringens ECOLOGY enterotoxin targeting of claudins at tight e2020424118 Growth, death, and resource competition in junctions in mammalian gut sessile organisms Alex J. Vecchio, Sewwandi S. Rathnayake, Edward D. Lee, Christopher P. Kempes, and Robert M. Stroud and Geoffrey B. West

vi u www.pnas.org Contents Downloaded by guest on September 26, 2021 e1917487118 Aquatic biodiversity enhances multiple e2014967118 Alternative splicing redefines landscape of nutritional benefits to humans commonly mutated genes in acute Joey R. Bernhardt and Mary I. O’Connor myeloid leukemia e2015094118 Global warming is causing a more pronounced Osvaldo D. Rivera, Michael J. Mallory, Mathieu dip in marine species richness around Quesnel-Vallie`res, Rakesh Chatrikhi, David C. Schultz, Martin Carroll, Yoseph Barash, Sara Cherry, the equator and Kristen W. Lynch Chhaya Chaudhary, Anthony J. Richardson, David S. Schoeman, and Mark J. Costello e1922305118 A model and test for coordinated polygenic epistasis in complex traits e2014856118 Experimental evidence of memory-based Brooke Sheppard, Nadav Rappoport, Po-Ru foraging decisions in a large wild mammal Loh, Stephan J. Sanders, Noah Zaitlen, Nathan Ranc, Paul R. Moorcroft, Federico Ossi, and Andy Dahl and Francesca Cagnacci e2001897118 Identification of a micropeptide and multiple secondary cell genes that modulate ENVIRONMENTAL SCIENCES Drosophila male reproductive success e2021219118 Declining greenness in Arctic-boreal lakes Cle´ment Immarigeon, Yohan Frei, Sofie Y. N. Delbare, Catherine Kuhn and David Butman Dragan Gligorov, Pedro Machado Almeida, Jasmine Grey, Le´a Fabbro, Emi Nagoshi, Jean-Christophe EVOLUTION Billeter, Mariana F. Wolfner, Franc¸ois Karch, and Robert K. Maeda e2019208118 Dead clades walking are a pervasive macroevolutionary pattern e2102804118 Inherited deficiency of stress granule ZNFX1 in B. Davis Barnes, Judith A. Sclafani, and Andrew Zaffos patients with monocytosis and mycobacterial disease e2013535118 Primate phageomes are structured by Tom Le Voyer, Anna-Lena Neehus, Rui Yang, Masato superhost phylogeny and environment Ogishi, Je´re´mie Rosain, Fayhan Alroqi, Maha Alshalan, Jan F. Gogarten, Malte Ru¨hlemann, Elizabeth Archie, Sophie Blumental, Fatima Al Ali, Taushif Khan, Manar Jenny Tung, Chantal Akoua-Koffi, Corinna Bang, Ata, Laurence Rozen, Anne Demulder, Paul Bastard, Tobias Deschner, Jean-Jacques Muyembe-Tamfun, Conor Gruber, Manon Roynard, Yoann Seeleuthener, Martha M. Robbins, Grit Schubert, Martin Surbeck, Franck Rapaport, Benedetta Bigio, Maya Chrabieh, Roman M. Wittig, Klaus Zuberbu¨hler, John F. Baines, Danielle Sng, Laureline Berteloot, Nathalie Boddaert, Andre Franke, Fabian H. Leendertz, Flore Rozenberg, Saleh Al-Muhsen, Aida Bertoli- and Se´bastien Calvignac-Spencer Avella, Laurent Abel, Dusan Bogunovic, Nico Marr, e2020563118 Heritable variation in telomere length predicts Davood Mansouri, Fuad Al Mutairi, Vivien Be´ziat, mortality in Soay sheep Dominique Weil, Seyed Alireza Mahdaviani, Alina Ferster, Shen-Ying Zhang, Bruno Reversade, Hannah Froy, Sarah L. Underwood, Jennifer Dorrens, Ste´phanie Boisson-Dupuis, Jean-Laurent Casanova, Luise A. Seeker, Kathryn Watt, Rachael V. Wilbourn, and Jacinta Bustamante Jill G. Pilkington, Lea Harrington, Josephine M. Pemberton, and Daniel H. Nussey

IMMUNOLOGY AND INFLAMMATION GENETICS e2013598118 Epigenetic reprogramming of tumor cell– e2023070118 BABEL enables cross-modality translation intrinsic STING function sculpts antigenicity between multiomic profiles at single- and T cell recognition of melanoma cell resolution Rana Falahat, Anders Berglund, Ryan M. Putney, Kevin E. Wu, Kathryn E. Yost, Howard Y. Chang, Patricio Perez-Villarroel, Shota Aoyama, Shari Pilon- and James Zou Thomas, Glen N. Barber, and James J. Mule´ See Profile Article, e2104246118, in vol. 118, issue 15 e2020484118 Immune cells fold and damage fungal hyphae e2022887118 Establishment of heterochromatin in Judith M. Bain, M. Fernanda Alonso, Delma S. Childers, domain-size-dependent bursts Catriona A. Walls, Kevin Mackenzie, Arnab Pradhan, Jan Fabio Nickels, Ashleigh Katrine Edwards, Leanne E. Lewis, Johanna Louw, Gabriela M. Sebastian Jespersen Charlton, Amanda Møller Avelar, Daniel E. Larcombe, Mihai G. Netea, Mortensen, Sif Christine Lykke Hougaard, Ala Neil A. R. Gow, Gordon D. Brown, Lars P. Erwig, Trusina, Kim Sneppen, and Genevie`ve Thon and Alistair J. P. Brown e2025182118 Integrated mutational landscape analysis of uterine leiomyosarcomas Jungmin Choi, Aranzazu Manzano, Weilai Dong, MICROBIOLOGY Stefania Bellone, Elena Bonazzoli, Luca Zammataro, e2025866118 Generation of SARS-CoV-2 reporter replicon Xiaotong Yao, Aditya Deshpande, Samir Zaidi, Adele for high-throughput antiviral screening Guglielmi, Barbara Gnutti, Nupur Nagarkatti, Joan R. and testing Tymon-Rosario, Justin Harold, Dennis Mauricio, Burak Xi He, Shuo Quan, Min Xu, Silveria Rodriguez, Shih Lin Zeybek, Gulden Menderes, Gary Altwerger, Kyungjo Goh, Jiajie Wei, Arthur Fridman, Kenneth A. Jeong, Siming Zhao, Natalia Buza, Pei Hui, Antonella Koeplinger, Steve S. Carroll, Jay A. Grobler, Amy S. Ravaggi, Eliana Bignotti, Chiara Romani, Paola Espeseth, David B. Olsen, Daria J. Hazuda, Todeschini, Laura Zanotti, Franco Odicino, Sergio and Dai Wang Pecorelli, Laura Ardighieri, Kaya Bilguvar, Charles M. Quick, Dan-Arin Silasi, Gloria S. Huang, Vaagn e2022578118 Virus-induced cell gigantism and asymmetric Andikyan, Mitchell Clark, Elena Ratner, Masoud cell division in archaea Azodi, Marcin Imielinski, Peter E. Schwartz, Ludmil B. Junfeng Liu, Virginija Cvirkaite-Krupovic, Diana P. Alexandrov, Richard P. Lifton, Joseph Schlessinger, Baquero, Yunfeng Yang, Qi Zhang, Yulong Shen, and Alessandro D. Santin and Mart Krupovic

Contents PNAS u April 13, 2021 u vol. 118 u no. 15 u vii Downloaded by guest on September 26, 2021 e2018329118 Cardiolipin aids in lipopolysaccharide e2014464118 Impact of prenatal maternal cytokine exposure transport to the gram-negative on sex differences in brain circuitry regulating outer membrane stress in offspring 45 years later Martin V. Douglass, Franc¸ois Cle´on, Jill M. Goldstein, Justine E. Cohen, Klara Mareckova, and M. Stephen Trent Laura Holsen, Susan Whitfield-Gabrieli, Stephen E. e2022269118 Structural basis for GTP-induced dimerization Gilman, Stephen L. Buka, and Mady Hornig and antiviral function of guanylate- e2013411118 A neural circuit for competing approach and binding proteins defense underlying prey capture Wen Cui, Elisabeth Braun, Wei Wang, Jinhong Tang, Daniel Rossier, Violetta La Franca, Taddeo Salemi, Yanyan Zheng, Benjamin Slater, Na Li, Cheng Chen, Silvia Natale, and Cornelius T. Gross Qingxiang Liu, Bin Wang, Xiu Li, Yinkai Duan, Yunjie Xiao, Ruijiao Ti, Dominik Hotter, Xiaoyun Ji, Lei Zhang, PLANT BIOLOGY Jun Cui, Yong Xiong, Daniel Sauter, Zefang Wang, e2023456118 Conditional destabilization of the TPLATE Frank Kirchhoff, and Haitao Yang complex impairs endocytic internalization Jie Wang, Klaas Yperman, Peter Grones, Qihang Jiang, Jonathan Dragwidge, Evelien Mylle, Eliana Mor, NEUROSCIENCE Jonah Nolf, Dominique Eeckhout, Geert De Jaeger, e2005483118 Overexpression of CD47 is associated with brain Bert De Rybel, Roman Pleskot, and Daniel Van Damme overgrowth and 16p11.2 deletion syndrome e2023548118 Multiple independent recombinations led to Jingling Li, Thomas Brickler, Allison Banuelos, hermaphroditism in grapevine Kristopher Marjon, Anna Shcherbina, Sravani Banerjee, Cheng Zou, Me´lanie Massonnet, Andrea Minio, Sagar Jing Bian, Cyndhavi Narayanan, Irving L. Weissman, Patel, Victor Llaca, Avinash Karn, Fred Gouker, Lance and Sundari Chetty Cadle-Davidson, Bruce Reisch, Anne Fennell, Dario e2025522118 4E-BP2–dependent translation in parvalbumin Cantu, Qi Sun, and Jason P. Londo neurons controls epileptic seizure threshold Vijendra Sharma, Rapita Sood, Danning Lou, POPULATION BIOLOGY Tzu-Yu Hung, Maxime Le´vesque, Yelin Han, Jeremy Y. e2025453118 Genomic stability through time despite decades Levett, Peng Wang, Shravan Murthy, Shannon of exploitation in cod on both sides of the Atlantic Tansley, Siyan Wang, Nadeem Siddiqui, Soroush Malin L. Pinsky, Anne Maria Eikeset, Cecilia Helmerson, Tahmasebi, Kobi Rosenblum, Massimo Avoli, Ian R. Bradbury, Paul Bentzen, Corey Morris, Agata T. Jean-Claude Lacaille, Nahum Sonenberg, Gondek-Wyrozemska, Helle Tessand Baalsrud, Marine and Arkady Khoutorsky Servane Ono Brieuc, Olav Sigurd Kjesbu, Jane A. Godiksen, e2025847118 Soluble α-synuclein–antibody complexes Julia M. I. Barth, Michael Matschiner, Nils Chr. Stenseth, activate the NLRP3 inflammasome in Kjetill S. Jakobsen, Sissel Jentoft, and Bastiaan Star hiPSC-derived microglia SUSTAINABILITY SCIENCE Dorit Trudler, Kristopher L. Nazor, Yvonne S. Eisele, Titas Grabauskas, Nima Dolatabadi, James Parker, e1917487118 Aquatic biodiversity enhances multiple Abdullah Sultan, Zhenyu Zhong, Marshall S. Goodwin, nutritional benefits to humans Yona Levites, Todd E. Golde, Jeffery W. Kelly, Joey R. Bernhardt and Mary I. O’Connor Michael R. Sierks, Nicholas J. Schork, Michael Karin, Rajesh Ambasudhan, and Stuart A. Lipton EDITORIAL EXPRESSIONS OF CONCERN e2016432118 Cholinergic suppression of hippocampal sharp-wave ripples impairs MEDICAL SCIENCES working memory e2104932118 The ReFRAME library as a comprehensive drug Yiyao Zhang, Liang Cao, Viktor Varga, Miao Jing, repurposing library and its application to the Mursel Karadas, Yulong Li, and Gyo¨rgy Buzsa´ki treatment of cryptosporidiosis + e2022874118 MrgprC11 sensory neurons mediate Jeff Janes, Megan E. Young, Emily Chen, Nicole H. Rogers, Sebastian Burgstaller-Muehlbacher, Laura D. glabrous skin itch Hughes, Melissa S. Love, Mitchell V. Hull, Kelli L. Haley R. Steele, Yanyan Xing, Yuyan Zhu, Henry B. Kuhen, Ashley K. Woods, Sean B. Joseph, H. Michael Hilley, Katy Lawson, Yeseul Nho, Taylor Niehoff, Petrassi, Case W. McNamara, Matthew S. Tremblay, and Liang Han Andrew I. Su, Peter G. Schultz, and Arnab K. Chatterjee e2006050118 Integrins protect sensory neurons in models of paclitaxel-induced peripheral MICROBIOLOGY sensory neuropathy e2105198118 Visualizing active viral infection reveals diverse Grace Ji-eun Shin, Maria Elena Pero, Luke A. Hammond, cell fates in synchronized algal bloom demise Anita Burgos, Atul Kumar, Samantha E. Galindo, Tanguy Flora Vincent, Uri Sheyn, Ziv Porat, Daniella Schatz, Lucas, Francesca Bartolini, and Wesley B. Grueber and Assaf Vardi

viii u www.pnas.org Contents Downloaded by guest on September 26, 2021