Neuron Development Marker Antibody Duo (Nestin, Tau) (ARG30083)

ARG30083 Package: 1 pair Neuron Development Marker Antibody Duo (Nestin, Tau) Store at: -20°C

Component

Cat. No. Component Name Host clonality Reactivity Application Package

ARG52441 anti-Tau antibody Chicken pAb Hu, Ms, Rat ICC/IF, WB 50 μl

ARG53358 anti-Nestin antibody Rabbit mAb Hu IHC-P, WB 50 μl [SP103]

Summary

Product Description Nestin is an intermediate filament protein expressed in dividing cells during the early stages of development in the central nervous system (CNS), peripheral nervous system (PNS). Upon differentiation, nestin becomes downregulated and is replaced by tissue-specific intermediate filament proteins. Tau proteins are proteins that perform the function of stabilizing microtubules. These proteins are abundant in nerve cells and are present to a much lesser degree in oligodendrocytes and astrocytes. Therefore, Tau proteins are also as a mature neural marker. ARG30083 Neuron Development Marker Duos (Nestin, Tau), providing two antibodies react with two neuronal markers in different stage, is useful for the researchers in neural stem cell and neurogenesis study.

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Target Name Neuron Development Marker

Alternate Names Neuron Development Marker antibody; Tau antibody; Nestin antibody

Properties

Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -101°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.

Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Full Name Antibody Duo for Neuron Development Marker (Nestin, Tau)

Research Area Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Developmental Biology antibody; Neuroscience antibody; Signaling Transduction antibody

www.arigobio.com 1/5 Images

ARG52441 anti-Tau antibody WB image

Western Blot: rat cortex lysate stained with Tau antibody (ARG52441) showing specific immunolabeling of the ~48, 65 & 75k tau isoforms.

ARG52441 anti-Tau antibody ICC/IF image

Immunofluorescence: cultured rat hippocampal neurons stained with Tau antibody (ARG52441) showing staining of tau in red along the neuronal processes.

ARG53358 anti-Nestin antibody [SP103] IHC-P image

Immunohistochemistry: Human Lung stained with Nestin antibody [SP103] (ARG53358)

ARG53358 anti-Nestin antibody [SP103] IHC-P image

Immunohistochemistry: Human Prostate stained with Nestin antibody [SP103] (ARG53358)

www.arigobio.com 2/5 ARG53358 anti-Nestin antibody [SP103] IHC-P image

Immunohistochemistry: Human Kidney stained with Nestin antibody [SP103] (ARG53358)

ARG53358 anti-Nestin antibody [SP103] IHC-P image

Immunohistochemistry: Human Skin stained with Nestin antibody [SP103] (ARG53358)

ARG53358 anti-Nestin antibody [SP103] IHC-P image

Immunohistochemistry: Human Ovary stained with Nestin antibody [SP103] (ARG53358)

ARG53358 anti-Nestin antibody [SP103] IHC-P image

Immunohistochemistry: Human Cervix stained with Nestin antibody [SP103] (ARG53358)

www.arigobio.com 3/5 ARG52441 anti-Tau antibody ICC/IF image

Immunofluorescence: Cortical neuron-glial culture from E20 Rat stained with ARG52441 anti-Tau antibody (green) at 1:2000 dilution, and costained with ARG10719 anti-MAP2 antibody [4H5] (red) at 1:1000 dilution. DAPI (blue) for nuclear staining.

The Tau antibody stains perikarya, dendrites and axons of neurons, while MAP2 antibody labels only dendrites and perikarya. As a result, perikarya and dendrites appear orange-yellow.

ARG52441 anti-Tau antibody WB image

Western blot: Rat brain, Rat spinal cord, Mouse brain and Mouse spinal cord lysates stained with ARG52441 anti-Tau antibody (green) at 1:10000 dilution.

Tau protein is expressed as multiple isoforms of different molecular weight, and so appears as multiple closely spaced bands in the region of the blot in the range from 48 kDa to 67 kDa.

ARG53358 anti-Nestin antibody [SP103] WB image

Western Blot: HeLa stained with Nestin antibody [SP103] (ARG53358)

ARG53358 anti-Nestin antibody [SP103] IHC-P image

Immunohistochemistry: Human Breast stained with Nestin antibody [SP103] (ARG53358)

www.arigobio.com 4/5 ARG53358 anti-Nestin antibody [SP103] IHC-P image

Immunohistochemistry: Human Colon stained with Nestin antibody [SP103] (ARG53358)

ARG53358 anti-Nestin antibody [SP103] IHC-P image

Immunohistochemistry: Human Endometrium stained with Nestin antibody [SP103] (ARG53358)

ARG53358 anti-Nestin antibody [SP103] IHC-P image

Immunohistochemistry: Human Cerebellum stained with Nestin antibody [SP103] (ARG53358)