Rabbit Anti-Human HIST1H3C (Phospho-Thr11) Polyclonal Antibody (CABT-L3651) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Rabbit Anti-Human HIST1H3C (Phospho-Thr11) polyclonal antibody (CABT-L3651) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Rabbit Anti-Human LAT (Phospho-Tyr191) polyclonal antibody. This antibody detects endogenous levels of Histone H3 only when phosphorylated at Thr11.

Specificity Target Modification: Phospho. Modification Sites: Human: T11; Mouse: T11; Rat: T12

Target Human Histone H3 (Phospho-Thr11)

Immunogen The antiserum was produced against synthesized peptide derived from human Histone H3 around the phosphorylation site of Thr11. Immunogen range: 1-50

Isotype IgG

Source/Host Rabbit

Species Reactivity Human, Mouse, Rat

Purification Affinity Purified

Conjugate Unconjugated

Applications IF, ELISA

Molecular Weight 15 kDa

Preparation The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.

Format Liquid

Concentration Lot specific

Buffer Rabbit IgG in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl and 50% glycerol.

Preservative 0.02% Sodium Azide

Storage Stable at -20°C for at least 1 year.

Ship Wet ice

Warnings For research use only.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Introduction Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Keywords HIST1H3C;histone cluster 1, H3c;H3.1;H3/c;H3FC;histone H3.1;H3 histone family, member C;histone 1, H3c;histone H3/c;

GENE INFORMATION

Gene Name HIST1H3C histone cluster 1, H3c [ Homo sapiens (human) ]

Official Symbol HIST1H3A

Synonyms H3/a, H3/c, H3/d, H3/f, H3/h, H3/i, H3/j, H3/k, H3/l, H31, HIST1H3A, histone H3.1

Entrez Gene ID 8350

UniProt ID P68431

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]