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Advances in Physiology, Pharmacology, and Pharmaceutical Sciences Modern Therapeutics 2012: Advances in Physiology, Pharmacology, And Pharmaceutical Sciences June 12-15, 2012 University of Toronto Toronto, ON, Canada A joint conference of: Canadian Society for Pharmaceutical Sciences Canadian Society for Pharmacology & Therapeutics Canadian Physiological Society Conference Management Committee: CSPS: Laszlo Endrenyi, Barbara Scollick CSPT: Kathy Gaebel, Fiona Parkinson, Cindy Woodland CPS: Scott Heximer Advances in Physiology, Pharmacology, and Pharmaceutical Sciences | 1s Conference Program Tuesday June 12 08:00-16:30 PRE-CONFERENCE WORKSHOP: "Drug Product Development: A QbD Approach" Presented by CSPS (Registration fees extra, not included in conference registration, lunch included) (Pharmacy Building Room 850) 11:30-12:00 Registration for Trainee Workshop and light lunch (Med Sci Bldg MacLeod Auditorium Lobby) 12:00-17:00 TRAINEE WORKSHOP: TECHNICAL SKILLS OF SUCCESSFUL SCIENTISTS (Med Sci Bldg - MacLeod Auditorium) Co-chairs: Fiona Parkinson and Donald Miller 12:00-12:10 Welcome 12:10-12:40 Small Molecule Binding can Interfere with Helix-helix Interactions and Modulate Amyloid Generation Gerhard Multhaup (McGill University) 12:45-13:15 AFM-Based Force Sensing on Individual Cells; Applications in Pharmacology Michel Grandbois (Université de Sherbrooke) 13:20-13:50 Drug Safety: Completing Clinical Trials with Real World Experience David Juurlink (ICES) 13:55-14:25 Centre for Clinical Investigation & Therapeutics: Enabling Technologies for Patient Oriented Research in the 21st Century Richard Kim (University of Western Ontario) 14:30-14:50 Break 14:55-15:20 Multidisciplinary Approaches Towards Understanding Ion Channel Function in the Nervous System Gerald Zamponi (University of Calgary) 15:30-16:00 Applications of Computer Aided Drug Design to High Throughput Screening and Rational Discovery Strategies Donald Weaver (Dalhousie University) 16:05-16:35 Model Systems for Biophotonic Imaging of Brain Responses to Injury and Therapies Jasna Kriz (Laval University) 17:00-20:00 CSPT Executive Board Meeting (Bumpkins Restaurant) 17:15-19:00 Trainee Social - O’Grady’s Pub, College Street 18:30 CSPS Board of Directors Meeting (Delta Chelsea Hotel - Whistler Boardroom) 2s | Modern Therapeutics Conference 2012 Wednesday June 13 07:00- Registration opens, Coffee & Muffins (Med Sci Bldg MacLeod Auditorium Lobby) 08:00-08:30 Welcome 08:30-09:30 Plenary 1: PHARMACOLOGICAL NEUROPHYSIOLOGY (Med Sci Bldg - MacLeod Auditorium) Chair: Fiona Parkinson All Roads to Psychosis Pass Through Dopamine Supersensitivity and Elevated D2High States Philip Seeman (University of Toronto) 09:30-10:00 NUTRITION BREAK AND VIEWING OF POSTERS AND EXHIBITS 10:00-12:15 Plenary 2: CLINICAL PRACTICE GUIDELINES FOR PHARMACOGENETIC TESTING: THE FIRST SIX DRUGS (Med Sci Bldg - MacLeod Auditorium) Chairs: Shinya Ito and Bruce Carleton Overview of Workshop Shinya Ito (Hospital for Sick Children) CSPT/CSPS State of the Art Lecture; MapQuest for Pharmacogenetic Tests: How to Arrive at Improved Clinical Outcomes Larry Lesko (University of Florida) CPG Development Process Bruce Carleton (University of British Columbia) Guideline for Pharmacogenetic Testing: Carbamazepine Ursula Amstutz (University of British Columbia ) Recommendations: Codeine Parvaz Madadi (Hospital for Sick Children) Recommendations: Cisplatin Colin Ross (University of British Columbia) Recommendations: Tamoxifen Ricardo Jimenez (University of British Columbia) Recommendations: Anthracyclines Colin Ross (University of British Columbia) Recommendations: Warfarin Kaitlyn Shaw (University of British Columbia) Next Steps, Distribution of CPG Materials Bruce Carleton (University of British Columbia) 12:30-13:30 LUNCH (MSB-Cafeteria Room beside Starbucks) AND VIEWING OF POSTERS AND EXHIBITS 13:00-13:30 Corporate Symposia (Med Sci Bldg - Cafeteria Room beside Starbucks) Advances in Physiology, Pharmacology, and Pharmaceutical Sciences | 3s 13:30-16:00 ALZHEIMER’S DISEASE CANCER STEM CELLS: THE NEW CANADIAN BE (Med Sci Bldg MacLeod NEW POTENTIAL CLINICAL GUIDELINES IN THE MIDST Auditorium) TARGETS OF CURRENT CHALLENGES (Med Sci Bldg Rm 3153) FROM A REGULATORY AND Chairs: Claudio Cuello, Zhong- INDUSTRY POINT OF VIEW Ping Feng Sponsored by (Pharmacy Bldg Rm 850) The Role of AMPAR FMC BioPolymer Trafficking in Memory Sponsored by Deficits Observed in Mouse Chair: Feridoun Karimi-Busheri Models AD BASF Basic and Translational Sheena Josselyn (University of Chairs: Isadore Kanfer and Biology of Cancer Stem Cells Toronto) Raimar Löbenberg William Matsui (Johns Hopkins Molecular Mechanisms University) The New Canadian Regulating the Abeta Bioequivalence Guidelines Amyloid Production Targeting Cancer Stem Cell- Eric Ormsby (Health Canada) Weihong Song (UBC) Specific Molecular Pathways Markus Frank (Harvard Medical Bioequivalence Review Caspases as Causative School) Challenges in a Changing Agents in Alzheimer's Regulatory Environment Disease Targeting Cancer Stem Cells: Jaigi Mathai (Health Canada) Andrea Leblanc (McGill Promises and Challenges University) Ahead Challenging Issues on the Feridoun Karimi-Busheri Demonstration of Neurotrophin Regulation and (NovaRx & University of Bioequivalence Cognitive Impairment in Alberta) Yu Chung Tsang (Apotex) Alzheimer’s Disease Margaret Fahnestock Panel Discussion Panel Discussion (McMaster University) Early Inflammation and NGF Deregulation in Alzheimer's and MCI Claudio Cuello (McGill University) 16:00-18:00 Poster Session (Med Sci Bldg Stone Lobby) 16:00-16:30 Senior Investigator Award Lecture (Med Sci Bldg MacLeod Auditorium) From Drugs to Patients: Personalizing Care, not Medicines Bruce Carleton (University of British Columbia) 18:00-20:00 Joint opening reception (Faculty Club) 4s | Modern Therapeutics Conference 2012 Thursday June 14 07:00 Registration opens, Coffee & Muffins (Med Sci Bldg MacLeod Auditorium Lobby) 08:00-10:00 FOOD INTAKE AND 08:00-09:00 CPS ORAL PRESENTATIONS REWARD AWARD LECTURES (FitzGerald Bldg Rm 103) (Med Sci Bldg MacLeod Audit (Med Sci Bldg Rm 3153) orium) Hyperpolarizing GABAergic Chair: Dion Brocks Transmission Requires the Chair: Stephanie Borgland GlaxoSmithKline/CSPS Early KCC2 C-terminal ISO Domain Effects of Insulin on VTA Career Award Lecture: Brooke Acton (University of Dopamine Neurons Toronto) Stephanie Borgland (University Non-invasive Drug Delivery – Importance of the Mevalonate of British Columbia) Rational Design and Characterization of Pathway in the Development Negative Emotional States Nanoparticulate Delivery and Survival of Purkinje Cells Andrew Barszczyk (University and Neurobehavioral Systems Adaptations in Brain Reward of Toronto) Circuitry Induced by Chronic Ildiko Badea (University of Glutamate and GABA/Glycine High-fat Feeding Saskatchewan) Co-released in the Immature Stephanie Fulton (Université Inhibitory MNTB-LSO Circuit de Montréal) CSPS Award of Leadership in Canadian Pharmaceutical Show Differential Dependence on Calcium Ghrelin Modulation of Sciences Dopamine Javier Alamilla (McMaster Neurotransmission Leslie Dan (Teva) University) Alfonso Abizaid, (Carleton Hydrogen Bonds are Critical University) for the Docking and 09:00-10:00 Formation of Functional Co-sensitivity to the (Med Sci Bldg Rm 3153) CX26/CX32 Gap Junction Incentive Properties of Channels Palatable Food and Cocaine Chair: Reina Bendayan Donglin Bai (University of in Rats; Implications for Advances in Research of Western Ontario) Comorbid Addictions Drug Transporters and Intracellular Trafficking of Francesco Leri (University of Metabolic Enzymes: Regulator of G-protein Guelph) Implications in Drug Signaling 4 (RGS4) Requires A Psychogenetic Study of Development Palmitoylation and RAB Family Function Food Addiction in Adult Men Yuichi Sugiyama (University of Guillaume Bastin (University of and Women Tokyo) Toronto) Caroline Davis (York University) 10:00-10:30 NUTRITION BREAK AND VIEWING OF POSTERS AND EXHIBITS Advances in Physiology, Pharmacology, and Pharmaceutical Sciences | 5s 10:30-12:30 CHALLENGING REAL NANOTECHNOLOGY IN NEUROSCIENCE PATIENT PHARMACOLOGY/ CANCER THERAPEUTICS: SYMPOSIUM TOXICOLOGY CASES FROM DETECTION TO (FitzGerald Bldg Rm 103) PRESENTING AT CANADIAN ERADICATION Chairs: Melanie Woodin and HOSPITALS (Med Sci Bldg Rm 3153) Zhong-Ping Feng (Med Sci Bldg MacLeod Auditorium) Sponsored by Presynaptic Vesicle Recycling Mechanisms and Chair: George Dresser Purdue Pharma Information Transfer Chairs: Shirley Wu and Katalin Toth (Université Laval) Marianna Foldvari New Molecules Enhancing Nanoparticle Delivery of Axonal Outgrowth and siRNA & Chemotherapy to Regeneration Tumors Zhong-Ping Feng (University of Leaf Huang (University of N. Toronto) Carolina Chapel Hill) Electrical Microstimulation: Drug Delivery with Modifying Neural Circuits Mitochondria-penetrating that are Linked to Cognitive Peptides Function Shana Kelley (University of Erik Cook (McGill University) Toronto) Treatment of Stroke using Lipid Nanoparticle PSD-95 Inhibitors Formulations of siRNA for Michael Tymianski (Toronto Gene Silencing in the Liver Western Research Institute) Pieter Cullis (UBC) Nanoscale Delivery of Drug Combinations for Overcoming Multidrug Resistance in Cancer Shirley Wu (University of Toronto) 12:30-14:00 CSPT: Med Sci Bldg MacLeod Auditorium - LUNCH and Annual General Meeting CSPS: Med Sci Bldg Rm 3153 - LUNCH, AGM and CSPS Award Presentations CPS: Med Sci Bldg Rm 2173 - LUNCH and Annual General Meeting VIEWING OF POSTERS AND EXHIBITS 6s | Modern Therapeutics Conference 2012 14:00-16:30 14:00-16:00 ADVANCES IN
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