Neural Circuit Basisof Behavior Andits Disorders
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Mind the Gender Gap!
THIS WEEK WORLD VIEW Cuts to the US HEADACHE? The brain stress FOSSILS Preserved remains disaster response are a false signals that produce of the half-billion-year- EDITORIALS economy p.7 migraine pain p.8 old jellyfish p.8 Science for all Many women are deterred from pursuing a career in science at the highest levels. Much more must be done to address the reasons behind this potential waste of human talent. hether female scientists will want to young female scientists have female role models. celebrate International Women’s Day WOMEN IN SCIENCE Some argue that setting a quota for women in on 8 March may depend on how far The gender gap and how to close it leading academic positions such as professor- Wthey look back in time. Things have changed, and nature.com/women ships will result in mediocre female candidates if you talk in terms of decades, there are consid- being promoted. But there is a gap in reasoning erable victories to cheer about. But despite those victories, progress here. Women and men are equally talented, so if men occupy a large now seems to have stalled. majority of high-level posts, there must be an awful lot of mediocrity That is clear from the package of articles in this week’s Nature (see among their number. Is mediocrity more acceptable in men? Quotas on page 21) that exposes the dismaying extent to which sexism still exists decision-making committees, however, do come with the inbuilt prob- in science. In the United States and Europe, around half of those who lem of overburdening the few women who already hold top positions. -
Sunday, March 29
Motivational Circuits in Natural and Learned Behaviors Sunday, March 29 3:00 pm Check-in 6:00 pm Reception (Lobby) 7:00 pm Dinner 8:00 pm Welcome and Opening Remarks 8:05 pm Session 1 Chair: Scott Sternson 8:05 pm Wolfram Schultz, University of Cambridge The dopamine reward signal codes economic utility 8:30 pm Nora Volkow, National Institute on Drug Abuse/NIH DA role in sustaining effort by engaging prefrontal circuits and disengaging default mode network and how these systems get disrupted in addiction 8:55 pm Refreshments available at Bob’s Pub NOTE: Meals are in the Dining Room Talks are in the Seminar Room Posters are in the Lobby 3/27/15 Motivational Circuits in Natural and Learned Behaviors Monday, March 30 7:30 am Breakfast (service ends at 8:45am) 9:00 am Session 2 Chair: Ron Stoop 9:00 am Naoshige Uchida, Harvard University Arithmetic of dopamine reward prediction errors 9:25 am Patricia Janak, Johns Hopkins University Parsing the role of dopamine neurons in learning and performance 9:50 am Joshua Dudman, Janelia Research Campus/HHMI The vigorous pursuit of reward 10:15 am Break 10:45 am Session 3 Chair: Gul Dolen 10:45 am Howard Fields, University of California, San Francisco Mesocorticolimbic mediation of learned appetitive behaviors: A circuit analysis 11:10 am Kent Berridge, University of Michigan Affective neuroscience of reward and motivation: Liking, wanting, dread and disgust 11:35 pm Jeffrey Friedman, Rockefeller University Radiowave control of feeding and glucose metabolism 12:00 pm Bernardo Sabatini, HHMI/Harvard -
Optogenetics: 10 Years After Chr2 in Neurons—Views from the Community
Q&A Optogenetics: 10 years after ChR2 in neurons—views from the community Antoine Adamantidis, Silvia Arber, Jaideep S Bains, Ernst Bamberg, Antonello Bonci, György Buzsáki, Jessica A Cardin, Rui M Costa, Yang Dan, Yukiko Goda, Ann M Graybiel, Michael Häusser, Peter Hegemann, John R Huguenard, Thomas R Insel, Patricia H Janak, Daniel Johnston, Sheena A Josselyn, Christof Koch, Anatol C Kreitzer, Christian Lüscher, Robert C Malenka, Gero Miesenböck, Georg Nagel, Botond Roska, Mark J Schnitzer, Krishna V Shenoy, Ivan Soltesz, Scott M Sternson, Richard W Tsien, Roger Y Tsien, Gina G Turrigiano, Kay M Tye & Rachel I Wilson On the anniversary of the Boyden et al. (2005) paper that introduced the use of channelrhodopsin in neurons, Nature Neuroscience asks selected members of the community to comment on the utility, impact and future of this important technique. euroscientists have long dreamed of and applied to a vast array of questions both in technique has had on neuroscience, we were Nthe ability to control neuronal activ- neuroscience and beyond. curious to know how researchers in the field ity with exquisite spatiotemporal precision. In the intervening years, improvements to feel the advances in optogenetic approaches In this issue, we celebrate the tenth anniver- early techniques have provided the community have influenced their work, what they think sary of a paper published in the September with an optogenetics tool box that has opened the future holds in terms of the application 2005 issue of Nature Neuroscience by a team the door to experiments we could have once of these techniques and what they see as the Nature America, Inc. -
Hacking the Soul New Technologies That Look Inside the Mind Will Make It Possible to Change What We Think, Feel, and Remember
VOLUME 117, NUMBER 4 | JULY/AUGUST 2014 | $5.99 Hacking the Soul New technologies that look inside the mind will make it possible to change what we think, feel, and remember. S:15.625” So quiet, it�s left our competition speechless. K900: Certified to deliver a quieter cabin and a smoother, better overall ride than the Audi A8 4.0T, BMW 750i and Lexus LS 460.* The Kia K900 was specifically designed to elevate the driving experience to a new level of luxury � one that even our most esteemed competitors have yet to achieve. With a high-strength tensile steel structure and multi-link, fully independent front and rear suspension, the K900 delivers one of the smoothest rides available. It also silences the road with a foam-padded, sound-insulated cabin and laminated window glass. Because sometimes the most luxurious sound is nothing at all. Challenge the luxury you know.™ K900 V8 expected Spring 2014. Initially available in certain markets with limited availability. K900 V8 with VIP package shown. Not all optional features are available on all trims. Some features may vary. *AMCI Testing Certified, comparably equipped MY 2014 vehicles; K900 VIP trim, Lexus LS 460 with optional air suspension. Untitled-2 2 FS:7.5625” 6/3/14 3:50 PM S:15.625” kia.com/K900 T:10.5” S:10” K900 V8 with VIP package shown. Untitled-2 3 FS:7.5625” 6/3/14 3:50 PM MIT TECHNOLOGY REVIEW VOL. 117 | NO. 4 TECHNOLOGYREVIEW.COM From the Editor ludwig wittgenstein was not tech- Wittgenstein would have been LeDoux on memory, page 30; Antonio nologically illiterate: he had studied especially derisive of the claims of neu- Damasio on emotions, page 48; and aeronautical engineering at the Univer- roscientists to meaningfully explain Rebecca Saxe on empathy, page 60). -
The 2021 Klerman & Freedman Awards
The 2021 Klerman & Freedman Awards AUGUST 2021 1 The Brain & Behavior Research Foundation is pleased to honor and recognize the extraordinary work of six outstanding young researchers with our annual Klerman & Freedman Prizes for exceptional clinical and basic research in mental illness. The Klerman and Freedman prizes recognize innovative thinking and remarkable talent across the field of neuropsychiatry. The prizewinners are selected by committees of the Foundation’s distinguished Scientific Council. Led by Dr. Herbert Pardes, this group of 180 prominent mental health researchers rigorously evaluates every grant application, identifying the most promising, high-quality science. The Council carefully selects those with the greatest potential for significant breakthroughs. Recognition for scientists early in their career helps them go on to receive further funding and is a precursor to further accomplishments. These six prizewinners have previously received awards through the BBRF Young Investigator Grant program, which supports early-career scientists as they gather pilot data and “proof of concept” for their innovative clinical and basic research. Our Young Investigator grants provide the seed funding young researchers need to pursue their hypotheses, concepts, and strategies that our Scientific Council believes have the greatest chance of advancing the field. We applaud these researchers for their exceptional work, and we thank our generous donors for their support of brain and behavior research to fund scientists working to produce better treatments, cures, and methods of prevention for mental illness. Together we will dramatically improve the lives of those living with mental illness and enable more people to live full, happy, and productive lives. Sincerely, Jeffrey Borenstein, M.D. -
The Early Warning Signs of Schizophrenia from HERBERT MELTZER, M.D
MAGAZINE Brain&BehaviorFormerly "The Quarterly" MARCH 2017 ADVICE ON The Early Warning Signs of Schizophrenia FROM HERBERT MELTZER, M.D. FROM FOUNDATION YOUNG INVESTIGATOR TO SCIENCE SUPERSTARS–NIMH DIRECTOR, JOSHUA GORDON, M.D., PH.D. & KAY TYE, PH.D. HOW TO INVEST IN MENTAL HEALTH (and how we put that investment to work) n Our 60,000 donors have joined together in the great challenge of modern medical science— overcoming mental illness. n Our 173 member volunteer Scientific Council has selected the best research strategies and scientists to pioneer in ending the suffering from brain and behavior disorders. n Our 4,000 research grantees have dedicated their outstanding talents and training to develop improved treatments and methods of prevention for mental illness. n Our foundation is the top non-government mental health research funder cited in published articles. JOIN US IN FINDING CURES FOR MENTAL ILLNESS. MAKE A GIFT TODAY. bbrfoundation.org n 800-829-8289 Contents 03 PRESIDENT’S LETTER Board of 04 2016 PARDES HUMANITARIAN PRIZE IN MENTAL HEALTH Directors HIGHLIGHTS FROM THE INTERNATIONAL MENTAL President & CEO Jeffrey Borenstein, M.D. HEALTH RESEARCH SYMPOSIUM 06 President, Scientific Council Herbert Pardes, M.D. INTERVIEW WITH A RESEARCHER: Joshua Gordon, M.D., Ph.D. Two Early NARSAD Grants Helped Launch the Career OFFICERS 10 Chairman of the Nation’s New NIMH Director Stephen A. Lieber Vice President SCIENCE FEATURE: Kay M. Tye, Ph.D. A New Approach to Anne E. Abramson 14 Treating Brain Disorders: Reprogramming Neural Circuits Secretary John B. Hollister Treasurer Arthur Radin, CPA 2016 DISTINGUISHED INVESTIGATOR GRANTS 18 DIRECTORS Carol Atkinson PARENTING: Advice on the Early Warning Signs of Eric F.