bioRxiv preprint doi: https://doi.org/10.1101/2021.04.26.441543; this version posted April 27, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 2 Stress-responsive Long Non-coding RNA, hsr, is a genetic modifier of JNK-dependent 3 Intrinsic Tumor Suppression in Drosophila 4 5 6 Anjali Bajpai1*, Sushmita Kundu1,2, Ravi Kant Pandey1,3, Bushra Ateeq1,2, Subhash C. 7 Lakhotia4, Pradip Sinha1,2 8 9 10 1Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur 11 208016, India. 12 2Biological Sciences and Bioengineering and The Mehta Family Centre for Engineering in 13 Medicine, Indian Institute of Technology Kanpur, Kanpur 208016, India. 14 3 Current Address: PierianDx India Pvt Ltd, Chattushringi, Gokhalenagar, Pune411016, 15 Maharashtra, India 16 4Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, 17 221005, India. 18 19 * Corresponding author: Anjali Bajpai,
[email protected] 20 21 ORCIDID: 22 23 A. Bajpai: 0000-0002-5645-2466 24 B. Ateeq: 0000-0003-4682-9773 25 S. C. Lakhotia: 0000-0003-1842-8411 26 P. Sinha: 0000-0002-9202-6050 27 28 Running title: Perturbations in hsr cooperate for epithelial tumor progression 29 30 Key words: Tumorigenesis, lncRNA, hsrω, stress response, intrinsic tumor suppression, 31 Drosophila 32 1 bioRxiv preprint doi: https://doi.org/10.1101/2021.04.26.441543; this version posted April 27, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved.