Abstracts of the 2018 AANS/CNS Joint Section on Disorders of the Spine
Total Page:16
File Type:pdf, Size:1020Kb
Abstracts of the 2018 AANS/CNS Joint Section on Disorders of the Spine and Peripheral Nerves Annual Meeting Orlando, Florida • March 14–17, 2018 (DOI: 10.3171/2018.3.FOC-ASPNabstracts) in the tetraplegic SCI population1. We investigate the combined J.A.N.E. Award Presentation effects of two neuromodulation strategies: transcutaneous electri- cal stimulation (TES) and buspirone pharmacological modulation, 100 Lateral Lumbar Interbody Fusion in the Elderly: A 10 for promoting upper limb motor recovery in chronic cervical SCI Year Experience tetraplegic subjects. Methods: A double-blind study protocol was used to deter- Nitin Agarwal MD; Andrew M Faramand MD; Nima Alan mine the effects of cervical electrical stimulation alone or in com- MD; Zachary J. Tempel MD; D. Kojo Hamilton MD; David O. bination with the monoaminergic agonist buspirone on upper limb Okonkwo MD, PhD; Adam S. Kanter MD motor function in subjects with chronic motor complete (ASIA B) cervical injury (n=6). Voluntary upper limb function was Introduction: Elderly patients, often presenting with multiple evaluated through measures of controlled hand contraction, hand- medical comorbidities, are touted to be at an increased risk of post- grip force production, dexterity measures, and validated clinical operative complications. As such, we describe our perioperative assessment batteries. Subjects underwent pre-intervention assess- outcomes in this cohort of patients over the age of 70 following ment followed by three treatment phases with TES and buspirone standalone LLIF. or placebo. A delayed post-treatment testing period was used to Methods: A retrospective query of a prospectively maintained assess for durable improvement in function. database was performed for patients over the age of 70 who under- Results: All subjects demonstrated improvement in hand went standalone LLIF. The preoperative and postoperative values strength and upper extremity functional metrics. Mean hand for the Oswetry Disability Index (ODI) were analyzed to compare strength increased greater than 300% after transcutaneous elec- outcomes after intervention. Femoral neck t-scores of the study trical stimulation plus buspirone. A corresponding improvement cohort were acquired from the bone density scans and correlated was observed in upper extremity functional metrics. Functional with the incidence of graft subsidence. Statistical analysis using improvements generally persisted after the study interventions t-test was performed with IBM SPSS Statistics (IBM, Armonk, NY). were discontinued. Results: Among the study cohort of 54 patients, the median Conclusion: We demonstrate that, with these novel inter- age at the time of surgery was 74 years (range, 70-87 years). ventions, the cervical spinal circuitry can be neuromodulated to Seventeen patients had at least 3 medical comorbidities at surgery. improve volitional control of hand function in tetraplegic subjects. Twenty-two patients underwent a one level, and 32 patients had The potential impact of these findings on individuals with upper 2 or more level fusions. The median length of hospital stay was limb paralysis could be dramatic functionally, psychologically, 2 days (range, 1-4 days). No statistically significant relationship and economically. was observed between the length of hospital stay and age at the time of surgery. There was one intraoperative death secondary to cardiac arrest, with a mortality rate of 1.9%. One patient developed Mayfield Clinical Science Award Presentation a transient femoral nerve injury. Five patients with radiographic graft subsidence subsequently required posterior instrumenta- 102 Crossing the Cervicothoracic Junction in Posterior tion. A lower femoral neck t-score < -1.0 correlated with a higher Cervical Decompression and Fusion: A Cohort Analysis chance of graft subsidence (p=0.006). The mean ODI 1 year post- operatively of 31.1 was significantly (p = 0.003) less than the mean Kevin T. Huang, MD; Maya Harary, BA; Muhammad M Abd- preoperative ODI of 46.2. El-Barr, MD, PhD; Yi Lu, MD, PhD; Michael W. Groff, MD, Conclusion: Standalone LLIF can be safely and effectively FACS; John H. Chi, MD, MPH performed in the elderly population. Despite an association with increased comorbidities, age alone should not be a deterrent when Introduction: Multilevel decompression and fusion is a well- considering an LLIF procedure in the elderly population. known procedure for spine surgeons. Current convention notes that the cervicothoracic junction (CTJ) has inherent instability and that surgeons should avoid ending constructs there. However, Mayfield Basic Science Award Presentation there exists little data to guide this practice.1 Methods: We retrospectively reviewed a consecutive series 101 Engaging Cervical Spinal Cord Circuitry with of 130 adult patients who underwent multilevel posterior cervi- Non-invasive Transcutaneous Electrical Stimulation and a cal decompression and fusion at our institution. All patients had Serotonin Agonist to Re-enable Volitional Control of Hand surgery for degenerative cervical conditions and received a fusion Function in Tetraplegic Patients that either stopped at C7 or extended beyond the CTJ. Data was collected on demographic, baseline, and intraoperative variables Nicholas Au Yong, MD, PhD; Yevgeniy Freyvert, MD; Tianyi as well as any complications or subsequent needs for reoperation. Niu, MD; Erika Morikawa; Sharon Zudnowski; Melanie Sarino; Results: A total of 67 patients had a fusion ending at the CTJ Yury Gerasimenko; Reggie Edgerton, PhD; Daniel C. Lu, MD, PhD compared to 63 whose fusion crossed the CTJ. The groups were not significantly different in terms of age (p=0.4594), smoking Introduction: Spinal cord injury (SCI) affects significant status (p = 0.7753), American Society of Anesthesiologists score societal and personal impact which scales with ascending level (p=0.2856), or amount of available follow-up (p=0.1437). Patients of injury. Recovery of upper extremity function is the top priority whose fusion crossed the CTJ had more levels fused (mean: 5.8 ± A1 Neurosurg Focus Volume 44 • March 2018 Unauthenticated | Downloaded 10/01/21 05:50 PM UTC AANS/CNS Joint Section on Disorders of the Spine and Peripheral Nerves: 2018 Meeting Abstracts 2.0 vs. 3.5 ± 0.8 levels, p<0.0001), longer surgical times (mean: Charles Kuntz IV Scholars 216.5 ± 82.6 vs. 148.5 ± 44.7 minutes, p<0.0001), and higher EBL (mean: 480 ± 775 vs. 115 ± 113 mL, p=0.0002). The groups did 104 Early Kyphoplasty is Associated with Reduced Risk not differ significantly in overall reoperation rate (10.4% vs. 9.5%, of Persistent Opioid Prescribing for Nearly 12,000 Privately- p=1.0000), but crossing the CTJ was associated with a higher rate Insured Patients with Osteoporotic Vertebral Fractures of wound dehiscence (7.9% vs. 0%, p=0.0246). Those patients with constructs ending at the CTJ had higher rates of adjacent seg- Jay Kiran Nathan, MD; Mitchell A Johnson, BS; Jennifer ment disease (4.5% vs. 0%, p=0.2449) and hardware complication Waljee, MD; Nicholas J. Szerlip, MD, FACS; Paul Park, MD; (4.5% vs. 1.6%, p=0.6198), but these differences were not statisti- Mark E. Oppenlander, MD cally significant. Conclusion: The relative merits of crossing the CTJ in pos- Introduction: Osteoporotic vertebral fracture is a painful con- terior cervical fusions are not a forgone conclusion. Deciding to dition typically requiring opioid analgesia. However, these particu- cross the CTJ may involve balancing increased surgical times larly frail patients face increased risks with even short-term opioid and wound complication rates on one hand with the possibility of use. There are mixed data on efficacy of kyphoplasty to reduce pain increased adjacent segment disease and hardware complications scores, and no large-scale data regarding opioid prescribing before on the other. versus after the procedure, the focus of the present study. Methods: Using claims from a large private US insurer, we identified adults with osteoporotic vertebral fracture who Kline Peripheral Nerve Top Abstract Presentation underwent kyphoplasty from 2001 to 2014, had at least 1 year of continuous insurance enrollment around their index procedure, 103 Lipid-rich Vesicular Transport in Myelinating and were prescribed opioids during this time. Intensity of opioid Schwann Cells In-vitro prescribing was classified based on CDC guidelines and average daily oral morphine equivalents (OME), and duration of prescrip- Joey Kevin Grochmal, MD, PhD tions relative to fracture and intervention was calculated. Results: A total of 11,964 adults met inclusion criteria, 4418 Introduction: Peripheral nerve myelin synthesis requires a (36.9%) of whom were opioid naïve prior to fracture. Median large volume of hydrocarbon molecules to support the exponential age was 77, and 71.9% were female. 10,365 patients (86.6%) production of lipid bilayer inherent in its formation; this provision underwent only 1 kyphoplasty, which was single-level in 80.1% occurs through a process that is yet unclear. of cases. Intensity of daily OME prescribing before fracture Methods: Using spectral confocal microscopy, we studied remained the same or decreased for 55.9% of patients immediately exogenous BFP expressing Schwann cells as they progressively after the procedure. 28.9% of patients were not prescribed any myelinated in GFP-DRG explant co-cultures (Figure 1: In-vitro opioids beyond 30 days following kyphoplasty, while multivariate myelination by exogenous BFP and endogenous GFP expressing logistic