What is most important to remember? If you have questions: Strong Internal • Take this medicine as directed at the same ties each day, at evenly Ask your doctor, nurse or pharmacist for spaced intervals more information about /. • Take until you finish the medicine, even if you are feeling better

• Do not start any new , over-the-counter drugs or herbal remedies without talking to your doctor

• Tell all doctors, dentists and pharmacists that you are using trimethoprim/sulfamethoxazole

• If your symptoms or health Strong Internal Medicine problems do not get better or if 601 Elmwood Avenue th they become worse, call your Ambulatory Care Facility, 5 Floor Rochester, NY 14642 doctor Phone: (585) 275 -7424

• This medicine will not treat a viral Visit our website at: Trimethoprim/Sulfamethoxazole www.urmc.rochester.edu/medicine/ - such as the common TM TM genera medicine/patientcare/ (Bactrim , Bactrim DS , cold or flu l- Septra DS ®): Important Patient Information

What does trimethoprim/sulfamethoxazole do? Are there any interactions with other drugs that I need What are some things that I need to be aware of when to worry about? • This medicine is a combination of two used taking trimethoprim/sulfamethoxazole? to treat certain bacterial • There are many drug interactions that may increase • Tell your doctor or pharmacist if you have a sulfa your risk of side effects () allergy, are allergic to How should trimethoprim/sulfamethoxazole be used? • Do not start new prescriptions, over-the-counter trimethoprim/sulfamethoxazole, or if you are allergic to • Use this medicine as directed by your doctor medicines, or herbal and dietary supplements without any other medicines, foods, or substances • Take at the same time each day, at evenly spaced telling your doctor • Make sure to tell your doctor if you are taking: intervals. To gain the most benefit, do not miss doses (Tikosyn®), or methenamine (Hipre®, Urex®) of this medicine What side effects could occur with trimethoprim/sulfamethoxazole? • Tell your doctor if you have or disease, • Take until you finish the medicine, even if you are • Upset stomach, throwing up anemia caused by lack of folic acid, asthma, severe feeling better allergies, or G6PD deficiency • Take with or without food. Take with food if it causes an • Diarrhea • Tell your doctor if you are pregnant, plan to become upset stomach • Not hungry pregnant during treatment, or are currently • Take with a full glass of water (8 oz). Drink extra water What should I do if I miss a dose of breastfeeding. If you become pregnant while taking this while taking this medicine unless otherwise directed by trimethoprim/sulfamethoxazole? medicine, call your doctor your doctor • Take a missed dose as soon as you think about it • If you are taking a blood thinner, you may need to have Who should know I am taking trimethoprim/ • If it is almost time for your next dose skip the missed your blood work checked more frequently while taking sulfamethoxazole? dose and go back to your normal dose time this medicine. Talk with your doctor

• Keep a list of all your medicines (prescription, natural • Do not take 2 doses at the same time or extra doses • You may get sunburned more easily so it is best to products, supplements, vitamins, over-the-counter) and avoid sun, sunlamps, and tanning beds. Use sunscreen give it to your healthcare provider (doctor, nurse, nurse and wear clothing and eyewear that protect you from practitioner, pharmacist, or physician assistant) the sun • It is best to avoid alcohol (beer, wine, mixed drinks) while on this medicine If you have any of the following side effects, call your doctor or visit the emergency room immediately: • Store in a cool, dry place. Protect from light and do not

• Very bad stomach pain, very bad back pain • Signs of an allergic reaction, like rash; ; store in the bathroom itching; red, swollen, blistered or peeling skin • Black, tarry or bloody stool • Keep out of reach of children and pets with or without fever; wheezing; tightness in • If you are unable to pass urine chest or throat; trouble breathing or talking; • Dark urine or yellow skin or eyes unusual hoarseness; or swelling of the mouth, • Persistent or severe diarrhea face, lips, tongue, or throat • Persistent or severe upset stomach or • Seizures throwing up • Hallucinations • Sign of liver problems; yellow skin or eyes;