Morphological, Phytochemical, and Pharmacological Studies of Grewia Asiatica: a Review

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Morphological, Phytochemical, and Pharmacological Studies of Grewia Asiatica: a Review Morphological, Phytochemical, and Pharmacological Studies of Grewia asiatica: A Review REVIEW ARTICLE Morphological, Phytochemical, and Pharmacological Studies of Grewia asiatica: A Review Zuneera Akram1,*, Rehana Perveen1, Aisha Noreen2, Maryam Inayat3, Muzammil Hussain1, Sadaf Ibrahim3, Mariam Razzak1, Kiran Qadeer2 1 Department of Pharmacology, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan 2 Department of Pharmaceutical Chemistry, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan 3 Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan 4 Department of Pharmacology, Faculty of Pharmacy, Ziauddin University, Karachi, Pakistan ABSTRACT Authors’ Contributions Pakistan has various variety of medicinally essential plants which have been 1 Conception & Study Design, Data Collection, guaranteed with useful therapeutic effects and better bearableness for side Drafting, Critical Review. 2,6 Data Collection, Critical Review. effects. One of the shrubs is Grewia asiatica (G. asiatica) commonly called 3,5,8 Data Collection, Drafting. Phalsa fruit, of Tiliaceae family, is grown in warmer season for edibility and 4 Conception & Study Design, Data Collection. 7 Data Collection. medicinal uses. In traditional folk medicine, Phalsa was used for its astringent, digestive and cooling properties whereas the unripened fruit has been used Article info. as an inflammatory reliever, antipyretic, and as an aid in blood and cardiac Received: January 29, 2019 Accepted: May 7, 2019 disorders. It’s leaves are applied on skin rashes while root and bark are Funding Source: Nil prescribed in rheumatic disorders and infusion owes demulsifying properties. Conflict of Interest: Nil Different parts of its specie display distinctive medicinal significance but still Cite this article: Akram Z, Perveen R, Noreen A, Inayat M, Hussain M, Ibrahim S, Razzak M, needs to be researched phytochemically. This review article is dependent on Qadeer K. Morphological, Phytochemical, and information of conventional uses, phytochemistry, and organic impacts of Pharmacological Studies of Grewia asiatica: A Review. RADS J. Pharm. Pharm. Sci. 2019; various parts of G. asiatica rich in supplements, for example, nutrients, 7(1): 53-62. minerals, amino acids-proteins and contain different bioactive mixes, as *Address of Correspondence Author: anthocyanins, tannins, flavonoids, glycosides and phenolic substances. The [email protected] extract preparation of different parts of the species showed different natural impacts, such as antibacterial, analgesic and antioxidant effects. Keywords: G. asiatica, pharmacological properties, nutrition, phytochemistry. INTRODUCTION pharmacological medicines particularly in field of cardiovascular and respiratory disorders and in The most established archeological records of plant treating various cancer forms. demonstrate its use for therapeutics for several Plant of Grewia genus comprises of bushes and trees thousand years, mostly used in health care system and significantly disseminated in warmer regions [2]. around the world common to all societies and Species found in Pakistan chiefly are G. asiatica L., cultures. Herbal prescriptions prospered through G. sapida Roxb., G. helicterifolia Wall., G. glabra hundreds of years and about 70% of all medicines Blume, G. tenax (Forssk.) Fiori., G. microcos L. and were herbal [1], yet now the pharmaceutical business few others. These species are of trading importance, has become active and synthetic medicines have medicinally as well as aromatically, and are source of started to assume control herbal medicine. As a income, in particular for poor families. G. asiatica of theme of data, investigation of conventional remedies Tilicaceae is the only significant edible fruit [3] and of has prompted the development of numerous ISSN (Print): 2521-8514 ISSN (Online): 2521-8484 RADS J. Pharm. Pharm. Sci. 53 Morphological, Phytochemical, and Pharmacological Studies of Grewia asiatica: A Review other plants of this family are economically useful and bark is utilized for treating stiffness, fruit as astringent are a natural source of fiber. and stomachic and when unripe they lighten irritation G. asiatica (Phalsa) is a fascinating shrub grown as a and is utilized in respiratory, cardiovascular and blood small fruit crop and a traditional medicine. Regardless diseases, and in fever [3]. Bark infusion is given as of its differing use, it has endured acknowledgement demulcent, febrifuge, and for bowels looseness. The and literature refusal. We have examined the plant leaves on skin ejections are connective and have characteristics, pharmacological and phytochemical anti-toxic activity. properties for acknowledgeable purpose. This article will fill in as a valuable snippet of data for further Economical Utilities evaluation of the plant. G. asiatica have tremendous utilizations for financially segments. Ripe phalsa fruit is eaten and made into Morphological Description soft drinks and squash in India during summer, leaves G. asiatica bush is 4-5 m extended, leaves are 5-18 utilized as animal food, bark as substitute cleanser in cm in length. The blooms are orchestrated in cymes, Burma and adhesive concentrate of bark is utilized in single blossom is yellowish in shading with 5 (12 mm) sugar. Fiber acquired from the bark is utilized to make prolonged sepals and 5(4-5 mm) shorter petals with 2 twines [12]. Wood can be used for making bows, cm in diameter [4]. The fruit is fleshy and fibrous shingles and shafts for conveying shoulders load [13]. drupe, grayish violet at development, with spherical depressed blackish spots with trichomes covered by Types of G. asiatica vast stellate. Seeds, are 1-2 in count, pointed toward In India, two different types are developed that differ a side with notched surface and hard coating, 1-2 regarding chemical and physical characteristics i.e., chambered with slick endosperm. Leaf, short and tall and short one (Table 1, Figure 1). The yield of peculiar, is heartily shaped, with 5-7 nerves, principle juice is marginally increased in the tall ones as nerves associated by venations that are parallel, edge identification with edibility while sugars have been serrate, stellately pubescent from upper side, and noticed in the dwarf ones. The tall type had extra tomentose [5]. Bark, grayish verdant outside and sugars, more protein and titrable acidity than the vermillion brown inside, or creamish in shade, with shorter ones [5]. thick, sinewy, intense and rough. G. asiatica is a self- pollinated reap. [6]. In January-February blossoms Table 1. Attributes of tall and dwarf Grewia show up and organic products develop during May asiatica types. and June. Skin of the fruit is light green over million Content (%) Tall Type Dwarf Type becomes purple or completely black when ripen completely. The ripen product is fragile, delicate and Edibility 91 91 secured by a thin white blush [7-9]. The natural product resembles berries with a sweet and sharp Kernel content 9 9 acidulous taste [10]. Juice content 68 66 Microscopic Characters Mash content 33 34 G. asiatica indicates nearness of Rosette and Moisture content 77 75 Prismatic crystals, Parenchymal cells, Crystal fibers, Spiral cells, Starch grains, Aleurone grains, Stellate Total sugar content 6 8 hairs, which are important microscopic diagnostic Reducible sugars 1 1 features [11]. Non-reducible sugars 4 7 Conventional Uses Titrable content 1 1 Use and development of phalsa natural product has been referenced in the old Indian writing and it has Mash protein 3 2 been utilized for different afflictions in Indian Kernel protein 9 7 medicinal system. The unripe organic products are said to evacuate vata, kapha and biliousness. Root Pulp protein 1 7 ISSN (Print): 2521-8514 ISSN (Online): 2521-8484 RADS J. Pharm. P harm. Sci. 5454 Morphological, Phytochemical, and Pharmacological Studies of Grewia asiatica: A Review Table 2. G. asiatica ash values. 100 90 Ash Types Value % 80 Tall Total ash 3.0 70 60 Dwarf Acid insoluble ash 1.4 % 50 40 Water-soluble ash 1.1 30 20 G. asiatica Extractive Values Content Content 10 0 The ethanol soluble values are found to be 45.4%, methanol soluble 46.2%, petroleum ether soluble 0.8%, chloroform soluble 1.6%, benzene soluble 14.0% and ethyl acetate soluble extractives 3.4% (Table 3) [8]. Figure 1. Camparison between the content % of tall Table 3. G. asiatica extraction values. and dwarf types of G. asiatica. Extract Value % Ethanol soluble 45.4 Harvesting and Production Methanol soluble 46.2 Summer is the natural product bearing season for Petroleum ether soluble 0.8 phalsa. Fruits perish in brief time thus should be Chloroform soluble 1.6 utilized for selling in 24 hours. Normal yield per plant Benzene soluble 14.0 of phalsa is 9-11 kg in one season [3]. Ethyl acetate soluble 3.40 G. asiatica Ash Content Nutritional Composition Total ash content yielded is 3.0%, where acid Calories and fat are low in G. asiatica (Phalsa) but it insoluble is 1.4% and water-soluble is 1.1% (Table 2) is high in vitamins, minerals and fiber [13]. Six basic [8]. micronutrients as discussed in Table 5 were additionally distinguished in dry weight (DW) and fresh weight (FW) in G. asiatica [14]. The detailed nutritional profile of the fruits is shown in Tables 4 and 5. Table 4. Nutritional composition of phalsa fruits. Nutrient Content Nutrient in 100 g Fruit Nutrient Content Nutrient in 100 g Fruit Calories (Kcal) 90.5 Phosphorus (mg) 24.2 Fat (Kcal) 0.0 Potassium (mg) 372 Moisture content 76.3 Sodium (mg) 17.3 Fat (g) < 0.1 Iron (mg) 1.08 Protein (g) 1.57 Vitamin B2 (mg) 0.264 Carbohydrates (g) 21.1 Vitamin, B3, Niacin (mg) 0.825 Dietary fiber (g) 5.53 Vitamin C, Ascorbic Acid (g) 4.385 Ash (g) 1.1 Vitamin A, Retinol (µg) 16.11 Calcium (mg) 136 Vitamin B1, Thiamine (mg) 0.02 Table 5. Mineral contents of G. asiatica fruit (Khan et al. [14]). Minerals Dry Weight (DW) per 100 g Fresh Weight (FW) per 100 g Cobalt, Co 33 µg 0.99 mg Chromium, Cr 36 µg 1.08 mg Copper, Cu 16 µg 0.48 mg Nickel, Ni 87 µg 2.61 mg Zinc, Zn 48 µg 144 mg Iron, Fe 1695 µg 140.8 mg ISSN (Print): 2521-8514 ISSN (Online): 2521-8484 RADS J.
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